Introduction to Oral Introduction to Oral Cancer Gene DatabaseCancer Gene Database

．資訊三 朱民晃 ．資訊三 朱民晃 B92902025B92902025．資訊三 陳皓遠 ．資訊三 陳皓遠 B92902062B92902062

The Tumor Gene Family The Tumor Gene Family DatabasesDatabases

Introduction(1/2)Introduction(1/2)

• http://www.tumor-gene.org/http://www.tumor-gene.org/• The Tumor Gene Family of Databases The Tumor Gene Family of Databases

contains information about genes which are contains information about genes which are targets for cancer-causing mutations; proto-targets for cancer-causing mutations; proto-oncogenes and tumor supressor genes. oncogenes and tumor supressor genes.

• These databases are designed to for These databases are designed to for biomedical researchers who work with biomedical researchers who work with tumor genes. tumor genes.

Introduction(2/2)Introduction(2/2)

• Tumor Gene DatabaseTumor Gene Database

• Breast Cancer Gene DatabaseBreast Cancer Gene Database

• Oral Cancer Gene DatabaseOral Cancer Gene Database

Oral Cancer Gene DatabaseOral Cancer Gene Database

• What information dose the database What information dose the database contain?contain?

• This database contains information This database contains information about genes which are targets for about genes which are targets for cancer-causing mutations in oral cancer-causing mutations in oral cancers.cancers.

• List of Oral Cancer GenesList of Oral Cancer Genes• A member of the Tumor Gene A member of the Tumor Gene

Database familyDatabase family• http://www.tumor-gene.org/Oral/oral.htmlhttp://www.tumor-gene.org/Oral/oral.html

Get the list of Oral Cancer Get the list of Oral Cancer Genes (1/2)Genes (1/2)

Click here to get information of the Oral cancer list

Get the list of Oral Cancer Get the list of Oral Cancer Genes (2/2)Genes (2/2)• List of Oral Cancer GenesList of Oral Cancer Genes

How to search the database How to search the database (1/4)(1/4)

Key in a Gene Name or a word in a fact you want to search

How to search the database How to search the database (2/4)(2/4)

Click the “Search” button to search

How to search the database How to search the database (3/4)(3/4)

Get 1 match of the gene “BAX”

Click the hyperlink of “BAX”

How to search the database How to search the database (4/4)(4/4)

OMIM ID NumberOMIM ID Number of NCBI

What can we get ? (1/2)What can we get ? (1/2)

• Cell Type Distribution Cell Type Distribution

• Clinical Clinical

• Complementation Complementation

• Function Function

• Gene Frequency (Tumors) Gene Frequency (Tumors)

• Protein Binding Protein Binding

• Regulation Regulation

What can we get ? (2/2)What can we get ? (2/2)

Flag

Link to Citation of NCBI

FlagsFlags

Primary Fact from a Full PaperPrimary Fact from an AbstractSecondary Fact from a Full PaperSecondary Fact from an Abstract Primary Fact from a Review Secondary Fact from a Review Unknown

Link to GeneCards (1/2)Link to GeneCards (1/2)

Click here to link to GeneCards website

Link to GeneCards (2/2)Link to GeneCards (2/2)

NCBI – OMIM (1/4)NCBI – OMIM (1/4)

Remember to choose “OMIM”

*600040 , the OMIM ID Number

NCBI – OMIM (2/4)NCBI – OMIM (2/4)

Click here; go to the OMIM homepage.

Click “FAQ” to get details about OMIM

NCBI – OMIM (3/4)NCBI – OMIM (3/4)

What do the symbols preceding a MIM number represent?

NCBI – OMIM (4/4)NCBI – OMIM (4/4)

Ex: An asterisk (*) before an entry number indicates a gene of known sequence.

ConclusionConclusion

• We can search the information about orWe can search the information about oral gene in the database.al gene in the database.

• We can get the OMIM ID about the gene iWe can get the OMIM ID about the gene in the NCBI database.n the NCBI database.

• We can get the list of genes in the oral dWe can get the list of genes in the oral database.atabase.

• We can link to GeneCards website.We can link to GeneCards website.

Thanks for your attention.