Juan Enriquez Excel Venture Management @EvolvingJuanweb.fedepalma.org/sites/default/files/files... · • Bioinformatics informs best strategy. Algal Product Titer Improvement

Juan Enriquez

Excel Venture Management

@EvolvingJuan

La luz eléctrica no surge por mejoras graduales

en la fabricación de velas…

A,B,C…

01101100011011110111011001100101

01101000011000010111010001100101

Hay décadas en las que no ocurre nada…

Y hay semanas en las que transcurren décadas.

6Vladimir Ilyich Lenin

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Notas de la presentación

Plastics Unfortunately that advice was… Wrong!

Silicón

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The right “one word” should have been “Silicon”

"Intel old logo" by Source (WP:NFCC#4). Licensed under Fair use via Wikipedia - https://en.wikipedia.org/wiki/File:Intel_old_logo.svg#/media/File:Intel_old_logo.svg

1968

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And the next year, 1968, birthed Intel

https://en.wikipedia.org/wiki/File:Intel_old_logo.svg

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Instead of becoming a Tupperware salesman.

$22 MM

Aprox = Honduras o Paraguay

Con 50 personas

Hokusai The Great Wave off Kanagawa

Tecnologia

Empresas

http://upload.wikimedia.org/wikipedia/commons/0/0a/The_Great_Wave_off_Kanagawa.jpg

Source :http://www.time.com/time/time100/scientist/profile/watsoncrick.html

A T C G

La vida es…

Código

http://www.freemars.org/jeff/2exp100/powers.htmMichael Schatz/ CSHLFlickr Gaetan Lee

http://www.freemars.org/jeff/2exp100/powers.htm

Leemos, copiamos, editamos,

Código de Vida

(Durante Siglos)

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Why “LifeCode”? Because for centuries, and even millennia, humans have been altering plants and animals to meet their needs.

Wild Mustard Weed

http://bn.wikipedia.org/wiki/%E0%A6%B8%E0%A6%B0%E0%A6%BF%E0%A6%B7%E0%A6%BE#mediaviewer/File:Yellow_mustard_flower.jpg

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For example, farmers have been playing with the genetics of mustard weed for a very long time.

http://bn.wikipedia.org/wiki/%E0%A6%B8%E0%A6%B0%E0%A6%BF%E0%A6%B7%E0%A6%BE

http://bn.wikipedia.org/wiki/%E0%A6%B8%E0%A6%B0%E0%A6%BF%E0%A6%B7%E0%A6%BE#mediaviewer/File:Yellow_mustard_flower.jpg

Suprimimos Flores =

Hojas másGrandes =

EsterilizamosFlores =

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If you suppress the flowers of mustard weed you get broccoli. Make its leaves bigger… you get kale. Sterilize its flowers, you get cauliflower. So just exactly what is “all-natural” and “organic” when much of what we consume in farmers markets is human designed and chosen?

http://bn.wikipedia.org/wiki/%E0%A6%B8%E0%A6%B0%E0%A6%BF%E0%A6%B7%E0%A6%BE

34,802 genesSHELL esencial para productividad

Entender la Genética

Conan Young, et al http://www.hno.harvard.edu/gazette/2002/11.07/11-teeth.html

http://www.hno.harvard.edu/gazette/2002/11.07/11-teeth.html



Anthony Atala Wake Forest Medical School

Anthony Atala Wake Forest Medical School

http://link.brightcove.com/services/link/bcpid1488655367/bctid2544245001

http://link.brightcove.com/services/link/bcpid1488655367/bctid2544245001

C O N F I D E N T I A L A N D N O T F O R D I S T R I B U T I O N | 48|C O P Y R I G H T © 2 0 1 6 S Y N T H E T I C G E N O M I C S , I N C.

The BioXp is the world’s first biological component printer

BioXp™ 3200

Sources: DecBio; technavio

Las algas son sustentables…

values based upon various literature reports

<$1/kg

Genovia BioCONFIDENTIAL

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Apr-12 May-12 Jun-12 Jul-12 Aug-12 Sep-12 Oct-12 Nov-12 Dec-12 Jan-13 Feb-13 Mar-13 Apr-13 May-13 Jun-13 Jul-13

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Best-in-class competitive benchmark

• Mutagenesis• Continuous evolution for fast growth• Impose growth limitation with pathway inhibitor• Bioinformatics informs best strategy

Algal Product Titer Improvementrapid advances using advanced genomic methods

51

IGEMHQ Flickr

Cinco principios básicos para Evolucionarnos …

#1 Tomar responsabilidad

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We have to take responsibility. We are now in charge. One can’t just blame Mother Nature, bad luck, bad karma, humans are in charge.

https://pixabay.com/en/photos/download/anime-1211688_1920.png?attachment&modal

Empezamos a controlar la evolución…

https://pixabay.com/en/photos/download/anime-1211688_1920.png?attachment&modal

Que hacemos con el Código de Vida…

Es el reto más grande que enfrenta la humanidad

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What we choose to do with life code is humanity’s greatest challenge and responsibility. No other thing we have learned or do comes close.

#2 Reconocer y celebrar la diversidad

Los humanos vamos a cambiar de manera fundamantalSource: Smithsonian Institution Douglas Theobald PhD www.talkorigins.org/.../images/hominids2.jpg

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Historically, it is normal and natural for there to be different versions of humanoids walking around at the same time. (After all our ancestors interbred with at least two of them, Neanderthals and Denisova).

#3 Respetar lo que escojan otros …

Creemosque los

humanossomos

diversos…

Charlie Sedanayasa Pak Yan David Robert Bliwas Peter Flickr

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And even though we think of ourselves as very diverse, because came so very close to compete extinction, we are an exceedingly homogeneous species.

Pero una tropa de 55 chimpancés …

Owenbooth Ash Flickrhttp://ucsdnews.ucsd.edu/archive/newsrel/science/atree.htm

Contiene más diversidad genética que 7 MM humanos

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In facyt a single troop of 55 West African chimps has more genetic diversity than seven billion humans.

http://ucsdnews.ucsd.edu/archive/newsrel/science/atree.htm

Algunos se van a alterar genéticamente…

Otros no.

#4 Separemos ¼ de la Tierra…

Para que solo Darwin opere

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We have to recognize we make mistakes, sometimes serious ones. Don’t take over all evolution. Have a backup plan. Lets set aside fully ¼ of the Earth and ¼ of the oceans, not necessarily contiguous, and let Darwin, and only Darwin, determine what lives and dies there, without humans intervening

Bio-hybrid AnimalRat Heart Cells, Rubber, Gold

Harvard School Engineering and Applied SciencesKit Kevin Parker

#5 Eduquémonos

Eduquémos a nuestros hijos

Solo trespalabritas…

Código de Vida

Moderador


Above all, educate yourself, educate your kids. You would not dare keep your kids ignorant of all digital code. Nor should you keep them ignorant of LifeCode. Those who understood digital code early did well. Others, perhaps like Benjamin, ended up Tupperware salesmen. LifeCode is the single greatest adventure humans have ever embarked on. Be a part of it. Don’t fear it. Guide it. Take part in it. Make it better. Whether you choose to be a scientist, ethicist, moralist, historian, entrepreneur, just remember that one word of advice… LifeCode Thank you.

Cinco posibles ideas para la palma…

Entender la genética

Entender la ciencia de la salud

Mejorar la ecología

Entender la mercadotecnia

Entender tecnologías alternas

Juan Enriquez

Excel Venture Management

@EvolvingJuan

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Juan Enriquez Excel Venture Management @EvolvingJuanweb.fedepalma.org/sites/default/files/files... · • Bioinformatics informs best strategy. Algal Product Titer Improvement