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1.1 1.2 1.3 1.4 Real-Time Fluidigm - () Affymetrix BioPlex CO2- -

56 6 11 15 21 23 23 27 33 33 37 39 39 41 43 45 45 48 49 52 54 62 68 68 76 82 85 88 95 95 100 103 105 105 108 108 110 114 115 120 125 127 128 128 133 135 136

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2.1 2.2

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3.1 3.2

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4.1 4.2 4.3

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5.1 5.2 5.3 5.4 5.5 5.6

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6.1 6.2 6.3 6.4 6.5

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7.1 7.2 7.3

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8.1 9.1 9.2 9.3 9.4 9.5 9.6 9.7 -

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10.1 EpMotion 10.2 10.3 10.4 ,ChIP,

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www.helicon.ru11 11.1 11.2 - 137 137 139 144 147 149 152 153 154 154 156 159 164 166 166 168 171 173 176 176 178 183 186 187 187 188 192 195 197 199 199 201 203 205 208 209 210 210 212 217 220 220 223 226 228 230 230 235 239 241

11.3 11.4

11.5 11.6 -

11.7 11.8 () 11.9 I II III

11.10 11.11 3D

11.12 11.13 11.14

11.15 III II I

11.16 11.17 11.18

11.19

11.20

11.21 -

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II1

1.1 1.2 1.3

247248 248 253 256 258 264 265 266 267 267 268 269 270 270 270 271 271 271 272 273 273 273 274 274 275

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15-50 6.1 6.2 6.3 T-

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7.1 7.2

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8.1 8.2

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10.1 10.2 10.3 10.4

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III1

1.1 1.2 ,LifeTechnologies(Invitrogen) LifeTechnologies(Invitrogen) LifeTechnologies(Invitrogen) ThermoFisherScientific(Fermentas) ThermoFisherScientific(Fermentas) ThermoFisherScientific(Fermentas) . ,,- LifeTechnologies(Invitrogen) LifeTechnologies(Invitrogen) (qRT-PCR)LifeTechnologies(Invitrogen)

277278 278 279 279 279 283 283 293 308 308 309 309 311 311 313 314 316 316 316 319 320

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2.1 2.2 2.3 2.4

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,,- 3.1

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www.helicon.ru 3.2 4 4.1 4.2 4.3 4.4 5 5.1 5.2 5.3 6 7 (qPCR)LifeTechnologies(Invitrogen) ,,-ThermoFisherScientific(Fermentas) ThermoFisherScientific(Fermentas) Amresco Amresco SYBR(LifeTechnologies) ThermoFisherScientific(Fermentas) LifeTechnologies(Invitrogen) LifeTechnologies(Invitrogen) ,Amresco LifeTechnologies(Invitrogen) LifeTechnologies(Invitrogen) ThermoFisherScientific(Fermentas) -- - - ThermoFisherScientific(Fermentas) TOPO (LifeTechnologies)

321 321 327 332 332 332 333 334 334 336 336 337 338 339 339 341 343 343 344 344 357 358 358 359 361 362 363 363 363 365 366 367 367 368 368 369 370 371 372 374 375 376 376 378 378 379 380 378 379 401 378

Gateway

7.1 (3D) (FBS)

7.2 7.3 7.4 7.5 7.6 7.7 8 9 8.1 9.1 9.2 10

10.1 ThermoFisherScientific(Fermentas) 10.2

11

VectorNTI 11.1 VectorNTIAdvance

4

5

www.helicon.ru

1.1

C1000Touch

1000-1000TouchS1000:,. ,0,20,596384. ,. C1000Touch.,S1000 1500. S1000, 1000Touch.

S1000

: 0,50,2, ,48-,96-384-. ,5/. 4-. , 8 ,. ,.. . 1000. . .

: 960,2(,). 2480,2(). 384-().

,/ , , , , , , , USB-,. , , , C1000/S1000 960,296-, 48+48,384- 5,0 0-100 +/-0,2 +/-0,4 30-100 24 +/-0,2 1000 12090 6 400 330x460x200 10,5

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1.1

01

BioRad1851196 BioRad1851148 BioRad1852196 BioRad1852148 BioRad1840196 BioRad1840148 1000Touch96 1000Touch48+48 S100096 S100048+48 961000- 48+481000-

T100T100 Bio-Rad, MyCycler.T100 , .

T100

: 96-0,2,. . . . .

,/ , , , , , , USB-,. , , , T100 960,296-( ) 4 4-100 +/-0,5 +/-0,5 30-100 24 +/-0,5 500, ,148(VGA) 1() 670 260x470x230 9

T100

BioRad1861096

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1.1Veriti

Veriti

Veriti- . VeriFlex, , . : 96 0,1 0,2 , 384 0,02 60 0,5. ,4,25/. (Fast96- 0,1). VeriFlex(). 6- ( 5)VeriFlex499C. Veriti12Veriti . 800,USB- . .

Veriti 96- 0,1 96- 0,2 384- 60- 0,02 0,5

, , , Veriflex ,/ , , ,

4-99,9 0,25 5C/ :>5C/ 48.48,96.96192.24DynamicArrays FR48.48DynamicArray12.76548.770DigitalArrays BioMarkDataCollectionSoftware BioMarkReal-TimePCRAnalysissoftware BioMarkGenotypingAnalysissoftware BioMarkDigitalPCRAnalysissoftware Pentium4;21-LCD; 1GB/sec;40GB;DVD; USB

BioMarkHDMXSystem. :BioMarkReader;:Real-TimePCR,DigitalPCR,Genotyping20 ;IFCControllerMX(48.48) 48.48DynamicArray,DigitalArray;1

BMKHD-BMKHD IFC-MX

EP1

FluidigmEP1 EndPointPCRFluidigmEP1 SNP , ,. .

: SNP , , , . 50000. (CNV), ,. IFC(IFC),, ,.

01

16

1.3

Fluidigm

01

EP1 1 230436960(2-3 ),50000 485,530,580+2 525,570,630+2 CCD 175 ,4-99 :>5C/ :>5C/ 48.48,96.96192.24DynamicArrays FR48.48DynamicArray12.76548.770DigitalArrays EP1DataCollectionSoftware EP1GenotypingAnalysissoftware EP1DigitalPCRAnalysissoftware Pentium4;21-LCD; , , Illumination

EP1MX+FC1System. :EP1Reader,:DigitalPCR,Genotyping20;IFC ControllerMX48.48DynamicArray,DigitalArray; ;1

EP1-EP1 IFC-MX

FluidigmAccessArraySystem

AccessArraySystem

Fluidigm Access Array System , NGS (Next Generation Sequencing) - Ion torrent, ABI Solid, Roche, Illumina. .,,,. AccessArray,,IFCController AX,. FluidigmAccessArraySystem, .AccessArray48-,48,. : (TargetEnrichment).,. -.- NGS... . , .

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www.helicon.ru

Fluidigm

1.3

FluidigmAccessArray. :2IFCAX(AccessArray48.48) AA-PKG-FC1 48.48AccessArray;;1

Fluidigm DynamicArray SNP48.48DynamicArray Dynamic Array SNP. FluidigmIFC.3--48.48,96.96,192.24.

- 48.48 DynamicArray 2304 48 48 96-2304 96.96 DynamicArray 9216 96 96 192-9216 192.24 DynamicArray 4608 24 192 384-4608

48.48DynamicArray(GT) (10) 96.96DynamicArray(GT) (10) 192.24DynamicArray(GT) (10) 48.48DynamicArray(GE) (10) 96.96DynamicArray(GE) (10)

BMK-M10-48.48GT BMK-M10-96.96GT BMK-M10-192.24GT BMK-M10-48.48 BMK-M10-96.96

01

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1.3

Fluidigm

01

48.48AccessArray Access Array .2304 , 48 48 .48 .

48.48AccessArray

, 48.48AccessArray 2304 48 48 30

48.48AccessArray (10)

AA-M10-48.48

DigitalArraydigitalPCRFluidigmDigitalArray digitalPCR., ,. 2-: 48.770DigitalArray.48()770. 36 960 . 12.765DigitalArray.12()765. 9180. 48.770DigitalArraydigitalPCR,(10 ) 12.765DigitalArraydigitalPCR,(10 )

48.770DigitalArray

BMK-M10-48.770 BMK-M10-12.765

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1.4

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: , , . . ( ). ,. 30.-. . . (,). . (1000). : . .

--- 1020600800 1015530535 70 50

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----(610) ----(620) (680) (2.)

LS----1 LS----2 0.05 0.03

01

20

1.4

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UVC/T-M-AR

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UVC/T-M-ARUVT-S--.-, .

: - , . ., (UVC/T-AR). . (). 25(UVT-S30). (15). -AR-,,. ,,-. -,/,100 1,.

, , , UVC/T-M-AR 690515555 480x645 32 UVT-S 1245580585 1200x520 58

-UVC/T-M-AR -UVT-S

UV-cleanerbox UV-cleanerbox1200

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2.1

5500SOLiDSystem5500xlSOLiDSystem5500SOLiD 5500 SOLID 5500xl SOLID - . SOLiD (Sequencing by OligonucleotideLigationandDetection) . , .

: 99,99%ExactCallChemistry(ECC). . 20Gb,300Gb. , . , (16). : : (SNP,, ). . Denovo(,). : (ChIP-Seq). (MeDIP-Seq). (RNA-Seq): (miRNA,siRNA,piRNA,esiRNA). ,,,. . -. : . .

01

22

2.1

01

5500SOLID 5500xlSOLID - 1,6 , 2, 6 , 20-30() 30-45() 180.() 300.() : 2 24 12 : 3 40 20 35,75,75+35,260 96-6 35..-11 75+35..60+60..76 ,,. ( ),.. 10-15 90.

99,99%(ECC)

(30- ,100-200 ,100000/ )

1 12 6

,

5500SOLID 5500xlSOLID

4452865 4460730

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2.1

IonPGMTMIonProtonTMIonPGMTMIonPGMTMIonProtonTM . IonPGMTM , , 2 . .Ion ProtonTM10. ,.

: (SNP, , ). . Denovo. . . .

: . . . 2. . IonPGMTMIonProtonTM,. . . ,, , . ,,IonPGMTM IonProtonTM .

02

24

2.1

IonProtonTM

02

IonPGMTMIonProtonTM. : , pH-. , pH- . .. , .

, IonPGMTM 31420.(20Mb) 316200.(200Mb) 3182.(1Gb) 3141,3. 3182.(1Gb) 31811. Chip-Seq 400 IonProtonTM ProtonI10.(10gb) ProtonII100.*(100gb) ProtonI165. ProtonII660. ProtonIII-1,2. () 200 99,5% 384 denovo; ,SNP (,,); ; ; ChIP-Seq,RNA-Seq,RIP-Seq,MeDIP () 1,5(100..) .9A 610510530 39 ~2(100..) .18A 542775474 59

,

, ,

*ProtonII2013. IonPGM .TM

4467542 4476610

IonProton

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2.2

ABIPRISM, ,,: .AppliedBiosystems ,. denovo. . HLA-. . 16S. ,,SNPs.

:SSCP,STR,VNTR,CSCE,LOH,MLPA,t-RFLP,,SNP,AFLP. ABIPRISM: 1. . 2. . 3. . 4. Dell-. 5. (DataCollectionSoftware),, . 6. DNA Sequencing Analysis Software GeneMapper Software . . : 1. DNASequencingAnalysisSoftware,,, AppliedBiosystems. 2. SeqScapeSoftware,. 3. Variant Reporter Software , . 4. GeneMapperSoftware,,,, . 5. GeneMapperID-xv1.2SoftwareAmpFISTR. 6. MicroSEQIDv2.2.

01

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2.2

()

01

ABIPRISM37303730xl 3730 (48 ) 3730 xl (96 ) ABI PRISM, .

ABIPRISM3730

: 48- (3730) 96-(3730xl). 48.,, . POP-6(),POP-7(). , (373048,3730xl96-). .

, , D-., ., , , , , ,. 610610950 ABIPRISM3730 48 ABIPRISM3730xl 96 36,50 50 525-650 488-514 10015 96384- 1870 3300 1000730890 180 24

ABIPRISM3730 ABIPRISM3730xl

4441719 4441718

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()

2.2

POPConformational AnalysisPolymer(CAP) POPConformationalAnalysisPolymer(CAP). (9%)(25). 4340379 4363929 (1x28) 4335615 (5x28) 4363935 (10x28) 4335611 (30x28) 4331247

POP-7Polymerfor 3730/3730xlDNAAnalyzers,1x28ml

POP-7Polymerfor3730/3730xlDNAAnalyzers, .

3730DNAAnalyzerCapillaryArray,36cm 3730DNAAnalyzerCapillaryArray,50cm

(48) 36.300. ,. (48) 50.300. ,. (96 )363730xl.300 . ,,SNP . (96 )503730xl.300 . ,,SNP . BigDye Terminatorv3.1CycleSequencingKit., denovo ,.

4331250

3730xlDNAAnalyzer CapillaryArray,50cm

4331244

3730xlDNAAnalyzer CapillaryArray,50cm

4331246

4337454(24) 4337455(100) 4337456(1000 ) 4337457(5000 ) 4335613 4336799 BigDyeTerminatorv3.1 CycleSequencingKit

3730RunningBuffer,10X 10-.100.500.

3730/3730xlDNA AnalyzerSequencing Standards,BigDye Terminatorv1.1 3730/3730xlDNA AnalyzerSequencing Standards,BigDye Terminatorv3.1

BigDyeTerminatorv1.1 3730.4 hsp69,. ROX,Rhodamine6G,Rhodamine110,TAMRA. BigDyeTerminatorv3.1 3730.4 hsp69,. ROX,Rhodamine6G,Rhodamine110,TAMRA.

4336943

02

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2.2

()

02

ABIPRISM35003500xl3500(8)3500xl(24) , , .

ABIPRISM3500

: 8-(3500)24-(3500xl). ,. 505 ,. (RFID). 6. : POP-7. , ,.

, , D-., ., , , , , ,. ABIPRISM3500 8 ABIPRISM3500xl 24 36,50 50 525-650 505 20 96-8 96384-; 8 1870 3300 610610720 82 24

ABIPRISM3500 ABIPRISM3500xl

4442009 4442010

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()

2.2

POP-4Polymerfor 3500/3500xLGenetic Analyzers POP-6Polymerfor 3500/3500xLGenetic Analyzers POP-7Polymerfor 3500/3500xLGenetic Analyzers 4393715(384) 4393710(960) 4393717(384) 4393712(960) 4393708(384) 4393714(960) 4404683 POP-4, / 960(36). POP-6 960 (50). POP-7 , ,384. (8,36) 3500GeneticAnalyzer . CapillaryArray,36cm /. (8,50) 3500GeneticAnalyzer . CapillaryArray,50cm . (24,36) 3500xLGeneticAnalyzer CapillaryArray,36cm 3500xl. /. (24,50) 3500xLGeneticAnalyzer CapillaryArray,50cm 3500xl. . BigDyeTerminatorv3.1 CycleSequencingKit BigDyeTerminatorv3.1CycleSequencingKit., denovo ,.

4404685

4404687

4404689 4337454(24) 4337455(100) 4337456(1000) 4337457(5000)

02

1- , 35003500xl. AnodeBufferContainer ., (ABC)3500Series .4 1- ,3500. 2, , CathodeBufferContainer . (CBC)3500Series ., .4. 3500 ConditioningReagent3500.3500 , ConditioningReagent, ,. 3500Series ., . 3100/3130/3500MatrixStandardSetBigDye Terminatorv1.1(+4C).2 31xxand3500Matrix , StandardsKit,BigDye 4, Terminatorv1.1 ,1. ROX,Rhodamine110,TAMRA,Rhodamine6G Sequencingstandardv1.13500,SequencingInstallStandard,BigDyeTerminatorv1.1,4./. 3500/3500xLSequenc4, ingInstallStandard, BigDyeTerminatorv1.1(1200 BigDyeTerminatorv1.1 .)/ . .ROX,Rhodamine6G,Rhodamine110,TAMRA SequencingInstallStandard,BigDyeTerminator v3.1.4, 3500/3500xLSequencBigDyeTerminatorv3.1 ingInstallStandard, (1200.)/ BigDyeTerminatorv3.1 .. ROX,Rhodamine6G,Rhodamine110,TAMRA

4393927

4408256

4393718

4336824

4404314

4404312

30

2.2

()

02

ABIPRISM310 ABI PRISM 310 . : 24.,, . : POP-4 ( ), POP-6 ( ), POPConformationAnalysis. (5). : . . . . .

ABIPRISM310

, , D-., ., , , , ,. ABIPRISM310 1 47,61 50 525-650 488-514 10015 4896 60 10015 610560870 94,5 12

ABIPRISM310

310-00-200/240-W

POPConformational AnalysisPolymer(CAP) POP-4Polymerforthe 310GeneticAnalyzer, POP POP-6Polymerforthe 310GeneticAnalyzer 310GeneticAnalyzer Capillary,36cm POPConformationalAnalysisPolymer(CAP) (9%)(25). 4340379

POP-4() (SNP)500 402838 (5). POP-6(), ,250(3). 36. .1 100.5. 402837 402839

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()

2.2

310GeneticAnalyzer Capillary,50cm 50c, 100. 402840 .2. BigDyeTerminatorv1.1Cycle SequencingKit. , . BigDyeTerminatorv3.1CycleSequencingKit., denovo ,. 310(10X),25. 310GeneticAnalyzerMatrixStandardsKit,dRhodamine.4, (ROX,TAMRA, Rhodamine110,Rhodamine6G). 310GeneticAnalyzerMatrixStandards,BigDye Terminatorv1.1.4 ,(ROX,Rhodamine6G,TAMRA,Rhodamine110). 310GeneticAnalyzerMatrixStandards,BigDye Terminatorv3.1.4 , (ROX,Rhodamine6G,TAMRA,Rhodamine110). 4337449(24) 4337450(100) 4337451(1000) 4337452(5000) 4337454(24) 4337455(100) 4337456(1000) 4337457(5000) 402824

BigDye Terminatorv1.1 CycleSequencingKit

BigDyeTerminatorv3.1 CycleSequencingKit

310and31xxRunning Buffer,10X 310GeneticAnalyzer MatrixStandardsKit, dRhodamine 310GeneticAnalyzerMatrixStandards,BigDye Terminatorv1.1 310GeneticAnalyzerMatrixStandards,BigDye Terminatorv3.1

403046

4336805

4336948

310/31xxGeneticAnalyzerSequenc310/31xxGeneticAnalyz- ingStandards,BigDyeTerminatorv1.1.4 erSequencingStandards, hsp69, BigDyeTerminatorv1.1 ().ROX,Rhodamine6G, TAMRA,Rhodamine110.

4336791

310/31xxGeneticAnalyzerSequenc310/31xxGeneticAnalyz- ingStandards,BigDyeTerminatorv3.1.4 erSequencingStandards, hsp69, BigDyeTerminatorv3.1 ().ROX,Rhodamine6G, TAMRA,Rhodamine110. Hi-DiFormamide .

4336935

4440753(5) 4311320(25)

02

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3.1

Affymetrix

03

AffymetrixAffymetrix . Affymetrix ,,,. Affymetrix,,. : : SNP(CNV).Affymetrix .,,,(SNP), (CNV).1,8.. .,.1 936225. .Affymetrix,, (LOH),(UDP). : . ,40,. 3IVT. ,,,30-. .,.AffymetrixmiRNAArray-,.,,, .

GeneAtlasSystemGeneAtlasSystem-Affymetrix . GeneAtlas 4 .

GeneAtlasSystem

: -: . . . . webNetAffx. GeneAtlas1PartekExpressAffymetrix EditionAriadnePathwayExploreAffymetrixEdition.

33

www.helicon.ruArraystrip

Affymetrix

3.1

Affymetrix GeneAtlas System Arraystrip, . , . . Array Strip GeneAtlasSystem ,.

, , , 4-, ,dB , , GeneAtlas LED 530 590 1 0,1/2 4- 30 12bits dat