Kuliah Farmasi Fisika II (Nanoteknologi)

7/26/2019 Kuliah Farmasi Fisika II (Nanoteknologi)

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engenalan Nanopartikel

sebagai Drug Delivery

System

Fea Prihapsara

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What is Nanoscale

1.27 107

m

ww.m

athworks.c

om

0.22

m

0.7 10-9

m

Fullerenes C60

12,756 Km22 cm 0.7 nm

10 millionstimes smaller

1 billiontimes

smaller

www.p

hysics.ucr.edu

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ano mens ons o rug e veryNanopartilesMattheolabakis, G., Rigas B., an Constantinies, !.!. Nanomedicine (2012) 7: 1577-1590

"he true nanorange isnarro#l$ e%ne as the 1&100 nm 'articles.

Markete in(ectable li'osomal)Dauno!ome"# Do$il"* analbumin&boun nano'articles)%&ra$ane"* anticancer rug'roucts, as #ell as the oralNanoCr$stal+ rug 'roucts)'apamune"# ()(ND"#

*ri+or" 1,# )egae" (and /N(%" *(NN%"*are #ithin the submicron range)100 1000 nm*.

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European Technology platformNano2Life

The nanomedicine Research agenda:

Nanodiagnostics: early and accuratediagnostics

-biosensors and miniaturized devices

-targeted imaging agents to highlight ofdisease

Targeted Drug Delivery: on thespot

-bring the drug to the target site andmonitor its impact

Regenerative Medicine: stimulatedrepair

-help the body to (re)built organs or systems6-1-16 10


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table 4.1

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3istory of Nanotehnology

~ 2000 Years Ago

Sulfide nanocrystals used by reeks and

!omans to dye "air

~ #000 Years Ago $%iddle Ages&

old nanoparticles of different si'es used to

produce different colors in stained glass (indo(s

#)*+ ,Nanotec"nology-

. /aniguc"i uses t"e term nanotec"nology for t"e first time

#)# 1% develops Scanning /unneling %icroscope

#)3 ,uckyball-

. Scientists at !ice 4niversity and 4niversity of Susse5

discover 6

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3istory of Nanotehnology

#)7 ,8ngines of 6reation-

. 9irst book on nanotec"nology by :; 8ric Dre5ler;

Atomic 9orce %icroscope invented by innig< =uate

and erbe

#)) 1% logo made (it" individual atoms

#))# 6arbon nanotube discovered by S; 1i>ima

#))) ,Nanomedicine- #st nanomedicine book

by !; 9reitas

2000 ,National Nanotec"nology 1nitiative- launc"ed

$4SA&

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Nanotechnolog$1

%ppliations of nanotehnology4 nerg$ storage an 'rouction

Water 'uri%cation

Foo 'rocessing an storage%edicine

For medial appliations4 Nanomediine

)ostly onerning diagnostis and drugdelivery

)ulti-disiplinary 5eld# utili6ing materialsienes# pharmaology# mediine# et.

1412alamanca&Buentello, F., et al. )003*. Nanotechnolog$ an the e5elo'ing Worl. Po! "ed# 2)3*, &6.

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Spectral transmittance of ZnO in aqueous solution

.

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Nanotehnology 3ealth and(nvironmental +onerns

($posure of human and the environment to nanomaterials at

dierent stages of produt life yleUS environmental protection agency, 2007 (epc.gov)6-1-16 16


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Nanotehnology

%ppliationsInformation Technology Energy

%edicine

Consumer Goods

Smaller, faster, more

energy efficient and

powerful computing

and oter !"#$ased

systems

%ore efficient and cost

effecti&e tecnologies for

energy production'Solar cells'(uel cells

')atteries')io fuels

Foods and beverages'*d&anced pac+aging materials,

sensors, and la$#on#cips forfood uality testing

ppliances and te!tiles'Stain proof, water proof and

wrin+le free te-tiles

"ousehold and cosmetics'Self#cleaning and scratc free

products, paints, and $etter

cosmetics

Cancer treatment #one treatment $rug delivery ppetite control $rug development %edical tools $iagnostic tests Imaging

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Nanosale )aterials

8ionanomaterials

18iologial materials utili6edin nanotehnology

& &roteins' en(ymes' $)' *)' peptides2 yntheti nanomaterials

utili6ed in &iomedialappliations

& Polymers# porous silion# ar&onnanotu&es

8one ell on poroussilion $ni%. o& 'ochester# 2007

+ross-lin:ed en6ymesused as atalyst $ni%. o&onnecticut# !torrs # 2007

3uman ell onPorous silion

!rotein

(n6ymesare usedas

o$idationatalysts

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)edial NanotehnologyorNanomediine

Nanomedicineis t"eapplication of

nanotec"nologyin medicine< including

to cure diseases and repair damaged

tissues suc" as bone< muscle< and

nerve

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Nanomedicine

vehicle for delivery of therapeutics into the body

2mall molecule rug com'ouns, N8-genes,'roteins, 5accines, etc. .,0

%dministration routes to reah systemiirulation or infeted organs and ells4 oral#intravenous# inhalation# oular# topial

9(e#ole, ., Mackra(, :., Naioo, !., ; Go5ener, ". )00*.


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Nanopartiles in oral drug delivery

/mproving sta&ility and solu&ility of drugs in./ trat

/nreasing &ioavaila&ility of drugs

e$tending half-life

*argeting drugs to spei5 ells# tissues andorgans

'eduing to$iity of drugs

4ube 8, Ng >, Nicola??o @8, Aarson :. ecti5e use o= reucing agents an nano'article enca'sulation in stabili?ingcatechins in alkaline solution. ood hemistry. 0101)*D66&/.3ube 8, Nicola??o @8, Aarson :. Chitosan nano'articles enhance the 'lasma e


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>eunggulan 'artikel berukuran nano $aknikemuahan 'enetrasi melalui ka'iler sehingga

keterseiaan obat 'aa sel target lebih maksimal.Nano'artikel a'at menghantarkan obat enganlebih baik ke unit $ang lebih kecil alam tubuh,

mengatasi resistensi akibat barrier %siologi tubuh,a'at itargetkan sehingga mengurangi toksisitas

an meningkatkan e%siensi istribusi obat,'eningkatan keterseiaan ha$ati obat $angabsorbsin$a renah, mengurangi risiko e=ek

sam'ing akibat 'enggunaan obat $ang

mengiritasi saluran cerna, 'erce'atan, #aktuisolusi obat, an meningkatkan is'ersi obat)!into Reis kk., 006 Ra#at kk., 006*.


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Nanopartiles

Re F, Moresco R, Masserini M. Nano'articles =or neuroimaging. @ournal o= !h$sics D 8''lie !h$sics. 0143)/*D0/001.

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Targeted drug delivery ACS Nano 2009, DO! "0."02"#nn900002m

1mpact of nanotec"nology on drug delivery

systems?

'/argeted drug delivery

'1mproved delivery of poorly (ater soluble

drugs

' 6o.delivery of t(o or more drugs

)anoscale $rug $elivery Systems

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/nteresting fats a&out nanomediine

1nterest in t"e area "as gro(n

e5ponentially

Nature 8iotehnology 200


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Nano-Techniques

Researchers, included in Pharmaceutical Industry,working to improve the bioavailability, biocompatibility,

and stability of various formulations of nanoparticle,

measure particle sie, particle shape, and eta potential!

"easuring particle sie in the nanometer

The #$-%&& dynamic light scattering nanoparticle sie

analyer provides sie information for nanoscale

suspensions and emulsionsthrough a simple, robust user

interface!

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Particle Characterization

/6-1-16

Nanopartile +harateri6ation 4 N+?@N+/


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In Vitro4

Pharmaology

8lood ontatproperties

/mmune ellfuntion

+ytoto$iity

)ehanistito$iology

terility

Physiohemial4

i6e and hape

+omposition )oleular

=eight urfae

hemistry /dentity Purity ta&ility

olu&ility

In Vivo4 %D)( afety (>ay

Nanopartile +harateri6ation 4 N+?@N+/%ssay +asade http://ncl.cancer.gov/assay_cascade.asp

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Nanopartile )anufaturing )ethods

6-1-16 1

*op

-Do=n

8ottom-

2p

(nergy

Preipitation

(mulsion-Diusion

N%NAP%'*/+?(

8?B

A?*/AN

3omogeni6ation

)illing

+ryogeni%pproahes

uper-+ritial Fluid*ehnologies

pray Free6ing into?iCuid

ltra-rapid Free6ing

ro=th


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)(N%P% P%'*/B(? N%NA 8/%)%B B( D%?%) (?


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Drug Delivery

1

4

1 % nanopartile arries thepharmaeutial agent inside itsore# =hile its shell isfuntionali6ed =ith a E&inding

agent

2 *hrough the E&inding agent# theEtargeted nanopartile reogni6esthe target ell. *he funtionali6ednanopartile shell interats =ith

the ell mem&rane

G *he nanopartile is ingestedinside the ell# and interats =iththe &iomoleules inside the ell

, *he nanopartile partiles &rea:s#and the pharmaeutial agent is2ourceD Com'rehensi5e Cancer Center 9hio

ni5ersit$

%. 8eause of their small si6es# nanopartiles

are ta:en &y ells =here large partiles =ould&e e$luded or leared from the &ody

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ite pei5 *argeting

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)odulation of PB pro5les of *8drugs1

12harma, 8., R. !ane$, et al. )004*. IChemothera'eutic eJcac$ o= 'ol$ )A&lactie&co&gl$colie* nano'articleenca'sulate antitubercular rugs at sub&thera'eutic ose against e


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/mproved the tissueonentrations of *8 drugs1

/

*8 drugs present

at )/+ levels atDay 7 and Day 9.

/n the ase of freedrugs# no drugould &e detetedin these tissuesafter ,I h

12harma, 8., R. !ane$, et al. )004*. IChemothera'eutic eJcac$ o= 'ol$ )A&lactie&co&gl$colie* nano'articleenca'sulate antitubercular rugs at sub&thera'eutic ose against e


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Nanotechnology for '( protection

$inc o)ide *$n+ and titanium dio)ide *Ti+particles have been widely used for many years as '(

filters in sunscreens!

Products using nanoparticles of $n+ or Ti+ aretransparent so have increased aesthetic appeal, are less

smelly, less greasy and more absorbable by the skin!

"any sunscreens and moisturisers available now usethese nanoparticles, including products from .oots,

/von, The .ody #hop, 01+r2al, Nivea and 'nilever!

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Nanotec"nology @ skin penetration

e;g< "ysical sunscreens $/i

< Bn&

ermal riskissues

E!posure

bsorption

Intrinsic To!icity

TiO+or ZnOnanopartiles

are olorless =ater-resistant J insolu&lematerials

are nonto5ic

ZnK essential element;DN% polymerases# DN%sta&ility100 m 10&1 m 10& m 10& m 10&4m 10&3 m 10&6m 10&/ m 10& m 10&7 m 10&10 m

)1 m* )1 mm* )1 Km* )1 nm*)100 nm*

2alic$lic aci)0.3 nm*

Ln9nano'articles

Water)0. nm*

3&nm3&nm

)0.1 nm*)10 nm*

Hair )0 m* RBC )/ m*

!enetrateskin

8''arentcut o

MW3000.7 nm

Rhino5irus)3 nm*

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Patents for Nanotechnology in 4osmetics

+ompan

y

%ppliation

*itle

Bey

?anguage@%&strat ;relevantlaim in &old

Date of

Filed

Pu&lished

%ppliation@PatentNum&er

6olgate.

almolive

Deodorant

(it" small

particle 'inc

o5ide

/"is invention

comprises a one

p"ase cosmetic

composition

("ic" can be

made as a stick

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Kuliah Farmasi Fisika II (Nanoteknologi)