Linfoma centrofolicular

7/26/2019 Linfoma centrofolicular

1/9

LINFO

CENTROFOLICUADRIANA GUTIRREZ F


2/9

LINFOMA NO HODGKIN

Grupo heterogneo de neop!"#!"$!#gn!" #n%opro#%er!t#&!" 'ue t#enend#%erente" $odeo" de (o$port!$#ento )re"pue"t!" ! tr!t!$#ento

Se or#g#n! h!*#tu!$ente en o" te+#do"#n%o#de" ) "e puede d#"e$#n!r h!"t!

otro" ,rg!no"-

.red#e((#,n $u(ho $!)or pord#"e$#n!r"e h!"t! "#t#o"e/tr!g!ng#on!re"-

C!"#0(!(#,n por (re(#$#ento


3/9

EFECTOS TARD1OS

C2n(er de pu$,n-

C2n(er de (ere*ro-

C2n(er de r#3,n-

C2n(er de &e+#g!-

Me!no$!-

L#n%o$! de Hodg4#n-

Leu(e$#! no #n%o(5t#(! !gud!-

L! d#"%un(#,n de &entr5(uo #6'u#erdo %ue uno de o" e%e(to" t!rd5o" #$port!nte" en o" p!(#ente" de LNH de gr!do !to "o*reente" !p!6o 'ue re(#*#eron $2" de 788 $g9$: de do/orru*#(#n!-


4/9

.RON;STICO < SU.ER=I=ENCIA

L#n%o$!" de (re(#$#ento ento

L#n%o$!" de (re(#$#ento r2p#do

.ron,"t#(o re!t#&!$ente (on un! $ed#!n! de "upede h!"t! 78 !3o"

E&ou(#,n n!tur! $2" (orn?$ero "#gn#0(!t#&o de e""e puede (ur!r (on reg5$#nten"#&o" de 'u#$#oter!p


5/9

LINFOMA FOLICULARCLASIFICACI;N 78@ de todo" o" LNH

8@ de o" #n%o$!" de (re(#$#ento ento

B8 !3o" o $2" ) "e pre"ent!n (onen%er$ed!d !$p#!$ente d#"e$#n!d! ene $o$ento de d#!gn,"t#(o

E (o$pro$#"o g!ng#on!r> en%er$ed!de"pn#(! ) de ! $du! ,"e!-

E reorden!$#ento de gen *(7 "een(uentr! pre"ente en $2" de 8@ de o"p!(#ente"

Gr!do I predo$#n#o dGr!do II (on propor((entro*!"to" B pgr!n !u$ento-Gr!do III predo$#n#o(entro*!"to" JB p

gr!n !u$ento-

Lo" LF" "e gr!d?!n hde !(uerdo ! ! propde (entro*!"to"


6/9

FACTORES DE RIESGOS1NTOMAS- Ed!d 8 !3o" &"- J8 !3o"-

7- L!(t!tode"h#drogen!"! 2(t#(!LDH "r#(! nor$! &"-ee&!d!-

- E"t!d#o e"t!d#o I o e"t!d#o II&"- III o e"t!d#o I=-

- Con(entr!(#,n de he$ogo*#n!78 g9 &"- 78 g9-

B- N?$ero de 2re!" g!ng#on!re" &"- J-

E (2n(er (o$#en6! gene(on ! h#n(h!6,n "#n doog!ng#o" #n%2t#(o" de (u!/#! o de ! !r#"t! de enOtro" "5nto$!" #n(u)en L! %!t#g!

P!+! de pe"o #ne/p#(! P!+! de !pet#to F#e*re


7/9

APORDAQE TERA.UTICO

Ant#(uerpo $ono(on! !nt#CD78

Nu(e,t#do" de ! pur#n!

A'u#!nte" or!e" u#$#oter!p#! (o$*#n!d!


8/9

CASE

A B7)e!rod o$!n pre"ented to our %!$#) (#n#( %or ! e o$!nThe on) (o$p!#nt" "he h!d ere %!t#gue> h#(h "he !ttr#*uted to !d!) th!t *eg!n !t !$> !nd hot !"he"- She den#ed %e&er> e#ght o!*do$#n! p!#n> $ed#(!t#on u"e> or re(ent %ore#gn tr!&e- She h!d ! o% h)per#p#de$#! !nd "urg#(! re$o&! o% ! (ut!neou" $e!no$! !t

7- Her t! "#gn" !nd ph)"#(! e/!$ ere nor$! #th the e/(ept#oen!rged e%t #ngu#n! )$ph node" !nd !ppro/#$!te) B en!rged r#g#ngu#n! )$ph node"- The node" ere %ree) $o&e!*e !nd nonten!dd#t#on! )$ph!denop!th) or "peno$eg!) !" %ound-


9/9

THE DIAGNOSIS

The p!t#ent" or4up #n(uded ! .!p "$e!r> (o$pete *ood (ount (o$prehen"#&e $et!*o#( p!ne CM.> !nd pe( !nd #ngu#n! utr!A te"t" ere nor$!> e/(ept the utr!"ound> h#(h re&e!ed "o#d #ngu#n! )$ph node" $e!"ur#ng -7 to - ($ !nd "o#d r#ght #ngu)$ph node" $e!"ur#ng - to -V ($- An !*do$#n! !nd pe( (o$to$ogr!ph) CT "(!n #th (ontr!"t #dent#0ed non"pe(#0( $e"enter#ngu#n!> retro(rur!> !nd retroper#tone! !denop!th)- An open *#op"

!rge"t #ngu#n! )$ph node re&e!ed %o#(u!r )$pho$!> ! %or$ o%Hodg4#n" )$pho$!- Hodg4#n" !nd nonHodg4#n" )$pho$! NHun(o$$on (!u"e" o% #ngu#n! )$ph!denop!th)- We (on"uted On!nd the) re(o$$ended ! po"#tron e$#""#on to$ogr!ph) .ET9CT "(h#(h "hoed #de"pre!d )$ph!denop!th)- A *one $!rro *#op")(on0r$ed %o#(u!r )$pho$! gr!de II> Ann Ar*or "t!ge III-

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Linfoma centrofolicular