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Okura Ken; Matsuoka Shigeru; Goto Ryosuke; Inoue Masayuki The twisted side chain of antillatoxin is important for potent toxicity: total synthesis and biological evaluation of antillatoxin and analogues. Angewandte Chemie (International ed. in English) (2010), 49(2), 329-32.

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Okura Ken; Matsuoka Shigeru; Goto Ryosuke ; Inoue Masayuki The twisted side chain of antillatoxin is important for potent toxicity: total synthesis and biological evaluation of antillatoxin and analogues. Angewandte Chemie (International ed. in English) (2010), 49(2), 329-32. . - PowerPoint PPT Presentation

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Okura Ken; Matsuoka Shigeru; Goto Ryosuke; Inoue Masayuki The twisted side chain of antillatoxin is important for potent toxicity: total synthesis and biological evaluation of antillatoxin and analogues. Angewandte Chemie (International ed. in English) (2010), 49(2), 329-32.

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Chemical biology is the use of chemistry, usually through small molecules made synthetically, to solve biological problems and to manipulate biological systems.

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Mukaiyama Aldol Addition

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Mechanism of the Mukaiyama Aldol Addition

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Pyrrolidine =

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Reactivity: Similar Trends for Reactivity of Enols, Enamines, and Enolates

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Reactivity of Enamines parallels that of Enolates

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EDC = 1-Ethyl-3- (Dimethylaminopropyl)carbodiimide

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mCPBA = meta-chloroperoxybenzoic acid

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Pummerer Rearrangement

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Mechanism of the Pummerer Rearrangement

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BOC protecting group

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Dppf = Diphenylphosphinoferrocene

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Suzuki Coupling Reaction

Miyaura, Norio; Yamada, Kinji; Suzuki, Akira. A new stereospecific cross-coupling by the palladium-catalyzed reaction of 1-alkenylboranes with 1-alkenyl or 1-alkynyl halides. Tetrahedron Letters (1979), (36), 3437-40.

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Mechanism of Suzuki Coupling Reaction

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