long α helix (α2) flanked on each side by a random coil loop (L1 or L2) and a short α helix (α1 or α3),

HISTONE VARIANTS

H2A.Z has apparently contradictory roles in gene activation and silencing; nucleosome turnover; DNA repair; heterochromatin

H2BH2B

NF-YBNF-YB

NC2NC2

Pole4Pole4CHRAC14CHRAC14

H2AH2A

NF-YCNF-YC

NC2NC2

CHRAC16CHRAC16Pole3Pole3

TAF12TAF12

H3H3 H4H4

TAF6TAF6TAF9TAF9

Histone fold proteins

TAF11TAF11 TAF13TAF13

TAF6LTAF6L

TAF4TAF4TAF4bTAF4b

TAFTAF33 TAFTAF1010

YEATS2YEATS2

TFIID

NC2NC2 NC2NC2

NC2-TBP-TATA

Repression by NC2

TAF12TAF12

TAF6TAF6TAF9TAF9

TAF11TAF11 TAF13TAF13

TAF4TAF4TAF4bTAF4b

TAFTAF33 TAFTAF1010

TFIID

TAF1

Histone acetylation

TAF12 and TAF6 H2B-H4 interface

TAF11TAF11 TAF13TAF13

TAF12TAF12

TAF9TAF9

Histone acetylation

TAF6LTAF6L

TAF4TAF4

TAFTAF1010?

SAGAPCAFGCN5

Spt-Ada-Gcn5-acetyltransferase

NC2NC2

Pole4Pole4CHRAC14CHRAC14

Histone acetylation

YEATS2YEATS2

ATAC

Pole3Pole3

GCN5 ATAC2

Nucleosome sliding

hSNF2/ACF1

Pole4Pole4CHRAC14CHRAC14

CHRAC16CHRAC16

hCHRAC

DNA Pol

DNA repair

Pole4Pole4CHRAC14CHRAC14 Pole3Pole3

hSNF2H DPB1

DPB2

ACF/CHRAC

CHRAC16

CHRAC14

hACF1

DNA Pol

DPB3CHRAC14

NF-YBNF-YB NF-YCNF-YC

NF-Y

TAF10

TAF5

TAF11TAF13

TAF7

TAF12

TAF1

TAF6TAF9

NF-YB

NF-YC

TBPTAF3

TAF4

TAF2

NF-YA

Cell. 2013 Jan 17;152(1-2):132-43. doi: 10.1016/j.cell.2012.11.047.Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R.SourceDipartimento di BioScienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy

Stem Cells. 2012 Nov;30(11):2450-9. doi: 10.1002/stem.1232.The short isoform of NF-YA belongs to the embryonic stem cell transcription factor circuitry.Dolfini D, Minuzzo M, Pavesi G, Mantovani R.SourceDipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy.