Melatonin Tugas NEurohormonal

7/21/2019 Melatonin Tugas NEurohormonal

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MELATONIN

Dian Wijayanti

(131620150002)Christophr !"

(131620150003)

ANTI A!IN! MEDICINE #AE$T%ETIC

&NI'E$ITA$ AD*A*AAN

+AND&N! 2015



M,atonin

• M,atonin -r.pa/an hor-on a,a-iyan ihasi,/an a,a- t..h yan-r.pa/an antio/sian potn (itr

//4 1)• M,atonin ihasi,/an i a,a- t..h

paa /,njar pina, (7a8i,s/a //4

200)• +rapa s.-r -,atonin s,ain

/,njar pina, aa,ah rtina4 /.,it4 .s.s4an s.-s.- t.,an ,a/an



• ",njar pina, tr,ta/ i tnahstr./t.r ota/ i ,a/an 9ntri/,/tia (D.o:o9i:h //4 2010)

• Da,a- /,njar pina,4 trapat .atip s, yait. pinealocytes, yania/an -njai tran an ,ap

yan r;.nsi -nhasi,/an ino,a-in(tr.ta-a -,atonin) an pptia4 ans, n.ro,ia, (A,< %.ssain4 2006)



ina, Anato-y

it.itary ,anit.itary ,an

ina, ,anina, ,an



nat.ran Ira-a $ir/aianan M,atonin

• $/rsi -,atonin -ni/.ti ira-asir/aian an apat ipnar.hi o,h si/,.stran = ,ap4 i-ana paa /onisis ,ap

pinealocytes a/an -ns/rsi -,atonin• $/rsi -,atonin i-.,ai paa p./., 2200

= 2300 an --.n:a/ paa 0300 =0>00

• "onsntrasi trnah -,atonin iapat/anpaa p./., 000 = 000 pai



The 24-Hour Cycle of MelatoninProduction

EEG-α wave ↑



• "onsntrasi -,atonin sanat rant.npaa .-.r

• +ayi yan r.-.r /.ran ari 3 .,an-ns/rsi -,atonin a,a- j.-,ah yansanat /:i, an -njai trat.r st,ah 3.,an /,ahiran

• $/rsi -,atonin paa ayi r.-.r/.ran ari 3 .,an ,.- opti-a,

• $/rsi ini -njai s-a/in trat.r

st,ah .sia 3 .,an yan /-.ian-nin/at -ni/.ti ira-a sir/aianpaa .sia 5 = 6 .,an



• $/rsi -,atonin trtini (rata < rata250 p?-,) aa,ah paa .-.r 1<3 tah.n

• Mn/ati .sia p.rtas4 s/rsi-,atonin a/an -.,ai r/.ran

• aa oran 8asa -.a nor-a,4 rratas/rsi -,atonin paa sian hari

r/isar paa 10 p?-, an 60 p?-,paa -a,a- harinya

• $i/,.s harian -,atonin saninnan si/,.s pai hina -a,a- anrtahan paa s.j/ nor-a, ji/a-ntap i s.asana ,ap (+.s:-i//4 200>)



"onsntrasi M,atoninrasar/an &sia



@a,, in M,atonin L9,s@a,, in M,atonin L9,s

thro.h Li;thro.h Li;

Age (years)

M e l a t o n i n ( p g / m l )

24

!

"

#

#2

# 2 $ 4 !% & "



• $/itar 0 -,atonin paa -an.siai/s/rsi ari a,a- t..h -,a,.i hpar4i-ana s, hpar --nt./ 6-

hydroxymelatonin saai sisa-tao,is- yan /-.ian i.ah-njai 6-sulfatoxymelatonin anglucuronide

• $j.-,ah /:i, -,atonin a/an i.an-,a,.i .rin an air ,i.r (+.s:-i //4200>)



The regulation of themelatonin secretion

$CN (s.pra:hias-ati: n.:,.s)

-,atonin

proj:t thin;or-ation

ao.t i,,.-ination

an,ion:,,s

th pina,,an

intrprts th in;or-ation onth ,nths o; th ay anniht

s:rts

;a:/(.n/no8

n)B

:ras tha:ti9ity o; $CN



+iosintsis M,atonin

• M,atonin ata. yan j.a is.t N<a:thy,<5<-thoytrypta-in isintsisari srotonin

• Tryptophan yan san rsir/.,asiia-i, an i.ah -njai 5<hyroytryptophan o,h tryptophan

hyroy,as

• 5<hyroytryptophan /-.iani/aro/si,asi -njai srotonin



• $rotonin i.ah -njai -,atonin-,a,.i ran/aian pross yan-,iat/an ni- N<a:ty,<trans;ras

(NAT) saai p-atas sintsis-,atonin an ni- hyroyino,<O<-thy,<trans;ras (%IOMT)(M:!i,ion4 2002)

• A/ti9asi /.a ni- ini itnt./ano,h -NA yan ipnar.hi o,hsi/,.s sian -a,a-



'ig The iochemical mediation system for serotonintransformation to melatonin in the pinealocytes sho*ing thesignal transduction path*ays from the retina to the cell and the

'NB室旁核para9ntri:.,ar n.:,

$C!B上頸神經節s.prior :r9i:a, a

NEB正腎上腺素Norpinphrin

NATB N<乙醯轉移酶N<a:ty,trans;ras

N< A:ty,srotoninO<-thy,trans;ras

松果體細胞



-nt./an -,atonin j.aipnar.hi o,h rapa /o-ponnn.trisi4 yait.B

a Asa- ;o,at an 9ita-in +64 yan-r.pa/an /oni- tryptophanD/aro/si,as

@,.9oa-in4 yan -r.pa/anpnha-at reuptake srotonin



@a:tors In9o,9 in thro.:tion o; M,atonin

• Th oy os not stor -,atonin Aai,y pro.:tion is n

• Liht?ar/ sina,s ;ro- th rtina tra9,

thro.h th opti:a, nr9 to th rain8hr thy :o-in 8ith sina,s ;ro-o.r “oy :,o:/4” t,,in th ,an tostart an stop -,atonin pro.:tion

• M,atonin :an a,so pro.: ir:t,yy th rtina its,; .nr :onitions o;ar/nss4 8ith no in9o,9-nt o; thpina, ,an



$tps in th ro.:tion o;M,atonin

1.1. The pineal gland draws tryptophan, an aminoThe pineal gland draws tryptophan, an amino

acid, from the blood.acid, from the blood.

2.2. Tryptophan is converted to serotonin in the gland.Tryptophan is converted to serotonin in the gland.This reaction is light-dependant.This reaction is light-dependant.

3.3. Serotonin is converted to melatonin.Serotonin is converted to melatonin.

4. Step 3 reqires dar!ness, sfficient calcim, and4. Step 3 reqires dar!ness, sfficient calcim, and

"itamin #-$"itamin #-$



@oos i:h in Tryptophan(mg/# grams)

4!

2!&

2.

$22

$%"

%#%&"

&4&

2 4 ! "

hole mil0

1lac0eyed Co*peas

1lac0 alnuts

Almonds

easame seeds

3luten our

oasted pump0in seeds

Tofu



@oos %ih in M,atonin

(pico-grams/gram of food)

#&.!

#$!!

#!

%"$

%

4!

$&"

% # #% 2

1arley

1anana

Tomatoes

3inger

ice

Corn

5ats



1 . 5

1 . 0

0 . 0

0 . 5

2 . 0

2 . 5

3 . 0

3 . 5

4 . 5

1 0 A M 2 P M 6 P M 1 0 P M 2 P M 6 A M 1 0 A M

M e l a t o n i n ( n g / l i t e r )

Nat.ra, Liht is +st ;orM,atonin ro.:tion



sptor M,atonin

• M,atonin -,a/./an anya/ ;.nsisio,oisnya nan /rja paa

rsptor --ran an n./,.s

• Na-.n4 anya/ ari ;.nsi trs.tyan tia/ trant.n paa rsptor4sprti pr,a8anan trhaap rai/a,as4 an rintra/si nanprotin sitoso, -isa,nya calmodulin



sptor M,atonin

+ri/atan nan 3 rsptorB

•MT1 B it-./an paa $CNhipota,a-.s4 /,njar hiposis4p-.,.h arah jant.n

•MT2 B tina an hipo/a-p.s

•MT3 B inja,4 ota/ an oran ,ainnya



otntia, -i:a,ini:ations

• Can:r• I--.no,oy• Mnstr.a, :y:, < ;rti,ity

• .rty onst• Larnin an --oryF Trat-nt o; :ir:aian rhyth- isorrs

( jet leg)

• Moo isorrs• $,p isorrs (inso-nia)• Antioiant potnt



roa, EG:ts o;M,atonin

• rot:ts aainst ;r rai:a, a-a;ro- :rtain :ar:inons4 hri:is4an raiation

• r9nts or h,ps ht t.-ors

• D,ays so- G:ts o; ain

• I--.n nhan:r



roa, EG:ts o;M,atonin

• Assists in :opin 8ith strss

• In:rass th ai,ity to prin:

p,as.r• Lo8rs :ho,stro,4 ,oo prss.r4

an ris/ o; hart rhyth- pro,-s

• Lo8rs ris/ o; ostoporosis



M,atonin saaiAntio/sian

• +ah/an a,a- osis /:i,4 -,atonin -a-p.-ntra,isir rai/a, as an -nha-attrjainya strs o/siati;

• $aai antio/sian4 -,atonin tr./ti apat-ntra,isir rai/a, hiro/si, an pro/sinitrit

• $,ain it.4 -,atonin j.a tr./ti apat-ntra,isir sin,t o/sin4 O24 hiron

pro/sia4 an nitric oxide 8a,a.p.na/ti9itasnya /.ran potnsia, (Inarra //42012)



• M,atonin --pnar.hi tin/atantio/sian ni-4 sa,ah sat.nya yait.$OD

• aa pn,itian yan i,a/./an o,h Ot.r/// (2000) p-rian -,atonin-nin/at/an a/ti9itas ni- $OD paahpar ti/.s

• n.r.nan /aar -tao,it -,atonin yait.6<$.,;atoy-,atonin a/an -n.r.n/ana/ti9itas C.7n$OD an -nin/at/an/aar LDL srta MDA ('ijayasarthy4 2010)



• M,atonin j.a rpran a,a--ntra,isir rai/a, as -,a,.ipnin/atan a/ti9itas $OD1 ata.

C.7n$OD -,a,.i ja,.r sito/ro--ito/onria >50 paaintr--ran -ito/onria (Inarra

//4 2012)



Li;sty, @a:tors that .:th M,atonin a/

• CaGin – C.ts -,atonin pro.:tion

in ha,; ;or 6 ho.rs

$trss

Toa::o

A,:oho,

=&p to >1 pr:ntr.:tion



Dr.s an $.pp,-nts that.: M,atonin

• Non<stroia, anti<inHa--atoryr.s

• +ta # Ca,:i.- Chann, +,o:/rs

• Anti<anity r.s # s,p ais

• 'ita-in +12 (3 - a ay)

• Anti<prssants



Inso-nia

• Typs o; inso-nia – jt ,a

– th :hroni: :ir:aian rhyth- isorrs

• Trat-nt – M,atonin an -,atonin aonists

r,ati9,y -i, si<G:t

8itho.t a,trin th s,p pattrn – Antiprssants

– Antihista-ins



$asona, aG:ti9 isorr($AD)

• Moo isorr

• th nor-a, iorhyth- is ist.r .rina sason4 sp:ia,,y a.t.-n<8intr

• $y-pto-s

– o9rs,p ? o9r at ? i:.,ty :on:ntratin?prssion

• Trat-nt – ,iht thrapy an s.pp,-ntation o;

-,atonin



M,atonin $.pp,-ntEG:ts

• %,ps inso-nia

– Esp:ia,,y in th ,r,y

– D:rass ti- to ;a,, as,p y 1> -in.ts

– I-pro9s s,p :in:y4 .t not tota,s,p ti-

• I-pro9s jt ,a – Whn ta/n th ay o; th Hiht an

:ontin. ;or 5 ays



Ca.tions an &n/no8ns o;M,atonin $.pp,-nts

• .rity

• La, a::.ra:y rarin J.antity

• otntia, ,on tr- a9rs G:ts• ossi, .nsira, si G:ts o;

hih oss4 s.:h as r.: ;rti,ity

• ossi, anro.s intra:tion 8ithprs:ription r.s



%aits that In:rasM,atonin ro.:tion

• In:ras pos.r to nat.ra,,iht an -ini-i pos.r toarti:ia, ,iht

• $,p in :o-p,t ar/nss• Eat ;oos ri:h in -,atonin4

tryptophan4 an 9ita-in +6

• A9oi a :a,:i.- :in:y• stri:t ;oo inta/ in nra,

• ra:ti: ;astin4 sp:ia,,y in

9nin ho.rs



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Melatonin Tugas NEurohormonal