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EFFECT OF CONTINUOUS POSITIVE AIRWAY PRESSURE ON LIPID PROFILE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Meta-Analisis Xiomara Cuadros

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EFFECT OF CONTINUOUS POSITIVE AIRWAY PRESSURE ON LIPID PROFILE IN

PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME: A META-ANALYSIS OF

RANDOMIZED CONTROLLED TRIALS

Page 2: Meta-Analisis Xiomara Cuadros

EFFECT OF CONTINUOUS POSITIVE AIRWAY PRESSURE ON LIPID PROFILE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

SYNDROME

Atherosclerosis 234 (2014)

446-453Authors:

Otolaryngology Institute of

Shanghai Jiao Tong

University

Huajun Xu, Hongliang

Yi, Jian Guan,

Shankai Yin

Effect of continuous positive airway pressure on lipid profile in patients with obstructive sleep apnea syndrome: A meta-analysis of randomized controlled trials. Xu, Huajun et al. Atherosclerosis , Volume 234 , Issue 2 , 446 - 453

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Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for development of dyslipidemia.

Continuous positive airway pressure (CPAP) is the first-line treatment for OSAS.

However, it is unclear whether CPAP improves lipid metabolism.

Objective: To review the effect of CPAP on lipid profile of patients with OSAS.

Introduction

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Materials and methods

Search strategy and selection of trails

It was systematically searched in

PubMed, Embase, and the Cochrane

library

All pre-September 2013 literature examining the

effects ofCPAP on blood

lipid profiles was included

No language or other

restriction was imposed.

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1. Only adults (aged 18 years) with newly diagnosed OSAS were studied.

2. CPAP was applied.

3. The duration of CPAP therapy was 2 weeks.

4. The level of at least one of TC, TG, LDL, or HDL was measured both before and after application of CPAP

Inclusion criteria

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1. Reviews, abstracts, case reports, letters, and non-human studies were excluded.

2. Treatment of adolescents (age < 18 years).

3. Diagnosis of OSAS in a manner other than by determination of the AHI (AHI 5) or the oxygen desaturation index (ODI) (ODI 7.5).

4. Failure to record lipid levels both before and after CPAP therapy, or the inadequacy of supplied information in terms of allowing such values to be estimated.

5. A duration of therapy of less than 2 weeks.

Exclusion criteria

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It was evaluated the quality of each study with the Jadad score.

Quality was independently assessed by two investigators. If disagreement arose, a third reviewer participated in resolution of the issue by discussion.

Quality assessment and Data extraction

Data extracted:

The first author; year of publication, the country in which the work was performedStudy design; number of subjects; sex, age, body mass index (BMI), and AHI or

ODI values of the participants.The duration of CPAP intervention; the extent of adherence to CPAP.Post-intervention TC, TG, LDL, HDL, weight, BMI, systolic blood pressure (SBP),

diastolic blood pressure (DBP), fasting glucose, and/or homeostasis model assessment of insulin resistance (HOMA-IR).

The mean differences in the levels of TC, TG, LDL, HDL, and weight, BMI, SBP, DBP, fasting glucose, HOMA-IR between the test and control groups.

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Results

Effect of continuous positive airway pressure on lipid profile in patients with obstructive sleep apnea syndrome: A meta-analysis of randomized controlled trials. Xu, Huajun et al. Atherosclerosis , Volume 234 , Issue 2 , 446 - 453

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TC TGLDL HDL

Effect of continuous positive airway pressure on lipid profile in patients with obstructive sleep apnea syndrome: A meta-analysis of randomized controlled trials. Xu, Huajun et al. Atherosclerosis , Volume 234 , Issue 2 , 446 - 453

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Heterogeneity and publication bias

The studies were homogeneous in nature. However, significant heterogeneity in TG data was evident

The Begg’s and Mazumdar rank correlation test did not suggest the presence of publication bias

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CPAP decreased TC level, SBP, and DBP of patients with OSAS but had no effect on BMI, HOMA-IR, or metabolism of TG, LDL, HDL, or serum glucose

CPAP was more effective in younger (<50 years) severely obese (BMI 35 kg/m2) patients when applied for 12 weeks.

CPAP therapy had a more obvious effect on TC level when such therapy was of long duration.

Discussion

OSAS was independently associated with abnormalities in lipid levels.

Toyama, Trzepizur, Lam, Kiely

Small sample sizes and did not control for

confounding factorsDyslipidemia was linked toobesity and not to OSAS per se.

Sharma, McArdle

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Few RCTs have addressed the topic of interest, and the total sample size was relatively small.

Negative results may not have been published, creating publication bias.

The duration of CPAP therapy (2-24 weeks) was relatively short, and may have been inadequate to change lipid profiles.

Physical activity and consumption of a high-fat diet can affect serum lipid levels independently of OSAS.

RCTs evaluating long-term CPAP intervention face an ethical problem, because long-time sham CPAP treatment may have serious consequences for OSAS patients.

Future RCTs with larger patient samples and longer follow-up durations remain challenging.

Limitations

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It was found that application of CPAP significantly reduced the TC level, especially in younger, more obese patients, and was associated with longer duration of CPAP application

Conclusion

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GRACIAS