Metabolic Pathways Poster - Sigma-Aldrich P R E N O I D S P H O S P H O L I P I D S D E G R A D A T I O N L I P I D B I O S Y N T H E S I S P E N T O S E S H E X O S E S P O L Y S

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  • 2H+

    H+

    OXALOACETATE

    PYRUVATE

    SUCCINYL-CoA

    GLUTARATE

    CITRATE

    MALATE2-OXO- ASPARTATE

    NO2-

    NO3-

    N2

    NH4

    CH3COSCoA

    ACETYL-CoA

    HOH

    CO2

    NAD

    TRANSAMINATION

    2H+

    2H+

    +

    CO2

    5-Amino-levulinate

    Glycine

    H+H+

    H+H+

    H+H+

    c

    H+ H+a

    F0

    F1

    F1

    2

    1

    10 c-sub-units

    AD P+ Pi

    a H+

    3.6.1.34

    H+-tra

    nsporting ATP synthase

    F6

    oscp

    ATP

    ADP +Pi

    FUMARATE

    UQH2

    UQ

    UQH2

    NADH+H+CH2COO-C(OH)COO-CH2COO-

    CH(OH)COO-CHCOO-CH2COO-

    -OOCCOCH2CH2COO-

    -OOCCH2CH2CO.SCoA

    -OOCCOCH2COO-

    CH3CH(OH)CH2CO.SCoA

    -OOCCH=CHCOO-

    CCCC

    Glyoxylate Cycle

    -OOCCHO

    GTP

    GDPATP

    +

    HEME Protoporphyrinogen Coproporphyrinogen Uroporphyrinogen Porphobilinogen

    5-Amino-levulinate

    COO-CH2CH2

    H2NCH2C=O

    FADH2

    FADCyt.b

    Fe-S

    SUCCINATEII

    CH3COCOO-

    PYRUVATE

    Pi

    X Y

    Cyt.c1

    Fe-S

    2e-2e-

    1e-

    1e-

    III

    2UQ UQ

    UQH22UQH2

    2UQ._

    UQ._

    Cyt.bL Cyt.bH

    Cyt.c

    IV

    CuA

    CuB

    CuA

    1.9.3.1

    2e-

    Heme a

    Heme a3

    2H+

    2H+4H+

    4H+

    2H+

    NAD+

    NADH+H+

    NAD+

    1.1.1.39

    1.2.4.12.3.1.123.1.3.43

    4.1.1.32

    4.1.3.7

    4.2.1.3

    1.1.1.41

    1.2.4.22.3.1.61

    6.2.1.4-OOCCH2CH2COO-

    1.3.5.1

    4.2.1.2

    1.1.1.37

    6.4.1.1

    4.1.3.8

    4.1.3.1

    4.1.3.2

    ISOCITRATE

    2.6.1.12.3.1.16

    4.1.1.71

    1.2.1.16

    5.1.99.15.4.99.2

    4.3.1.1

    1.4.1.2 1.4.1.14

    6.3.5.4

    1.6.6.11.7.99.4 1.7

    .7.1

    1.6.6.4

    1.18.6

    .1

    2.3.1.37

    1.10.2.2

    1.10.2.2

    H++

    33

    ATP

    ADP

    ENDERGONIC REACTION

    1.6.5.3

    I

    FMNH2

    FMN I

    1.6. 5.3

    2Fe -S (5 Clusters)

    H+ H+H+ H+

    ATP

    4H+

    2H+

    2H+or

    H+

    PHOTO-SYSTEM

    l

    O2

    3.6.1.34

    NADP+

    GlyceraldehydeRibulose-1,5-bis-P

    2

    88

    H+c

    32

    a

    32

    1

    2

    1

    3

    3

    H+

    H+

    H+

    H+

    H+H+

    H+

    H+ H+H+

    H+H+H+H+

    H+

    H+H+H+

    H+H+

    H+

    H+

    H+

    H+

    H+

    H+H+

    H+H+

    H+H+

    H+H+H+Translocated protons

    H+

    H+H+

    H+Pi

    Ferredoxin

    4H+PC PC

    PC

    PQH2

    2PQH2

    PQ_.

    2PQ_.Fe-S Cyt.f

    PQ

    2PQ

    Cyt bf

    2e-

    1e- 1e-

    2e-

    2e-

    2e-

    2e-

    Cyclic Ph

    otophosphorylation

    PQ

    PHOTO-SYSTEM II

    Cyt bc

    Non-cyclic electron flow

    2e-2e-

    Mn2e-

    *

    Protons from Water

    H2O

    H+

    H+

    2H+2H+

    ATP synthase

    CO2Fixation

    H+

    ADPPi

    H+

    NADPH+H+

    eeeATPTHYLAKOID MEMBRANE

    CHLOROPLAST OUTER MEMBRANE

    THYLAKOID LUMEN

    STROMA

    (electric current)

    P680Chl.a

    QA

    QB

    Pheophytin

    P700

    Chl.A0

    A1

    Fe-S

    ATP

    ADP

    ATP

    1/2O2

    H2O

    PQH2

    To Brain -

    AMINO

    ACIDS

    PYRIMIDINES

    PURINES

    CATECHOLAMINES

    AROMATIC

    AMINO

    ACIDS

    hvVISION

    LIPID

    PHOTOSYNTHESIS

    PORPHYRINS

    STEROIDS

    ISOPRENOIDS

    PHOSPHOLIPIDS

    DEGRADATION

    LIPID

    BIOSYNTHESIS

    PENTOSES

    HEXOSES

    POLYSACCHARIDES

    COCH CH(NH )COO2 3+

    FOLICACID

    C1POOL

    VALINE

    ATP

    ATP

    4.1.1.4 1.1.1.30

    CH COCH3 3

    CH COCH COO3 2

    CH CH(OH)CH COO3 23-OH-ButyrateAcetone

    Acetoacetate

    KETONE BODIES

    HYALURONIC ACID DERMATAN BLOOD GROUPSUBSTANCESPEPTIDO-GLYCAN

    N-Ac-Neuraminate(Sialate)

    UDP-Iduronate

    UDP-N-Ac-Galactosamine UDP-

    Galacturonate

    GDP-Fucose

    TDP-Rhamnose

    ADP-Glucose

    UDP-Glucose

    TDP-4-Oxo-6-deoxyglucose

    MANNOSE

    CHITIN CHONDROITIN PECTIN

    ALGINATES

    INULIN CELLULOSE

    O-ANTIGENS STARCH GLYCOGEN

    LACTOSE

    GALACTOSE

    O

    OH

    HO

    OH

    OH

    CH3 O

    OPPTO

    OH

    OH

    O

    OHACNH

    HO OH

    O

    OHHO OPPU

    NHAC

    OH

    OH OH

    OH

    HO

    OH

    NHCOCH

    OH HO

    O

    OPPG

    CH OH2

    HO

    P

    UDP-N-Ac-Glucosamine

    pyruvateN-Ac-Mannosamine-6-P UDP-Glucuronate

    GDP-Mannose

    N-Ac-Mannosamine UDP-N-Ac-Glucosamine N-Ac-Glucosamine-6-P

    Sorbitol

    Fructose-1-P

    Erythrose-4-P

    3-Dehydrogulonate

    L-Xylose

    L-Lyxose

    D-Xylulose

    D-Ribose

    RibitolL-Arabitol L-Xylulose

    L-Ribulose L-Ribulose-5-P

    L-Xylulose-5-P

    L-Arabinose Xylitol D-Xylose

    D-Arabinose D-Ribulose

    ASCORBATE

    2, 3-Dioxogulonate

    N-Ac-Glucosamine-1-P

    Inositol-PInositolGlucuronateGulonate

    Gulonolactone 2-Oxogulonolactone

    Fructose

    6-P-Gluconate

    D-Ribulose-5-P

    D-Xylulose-5-P

    Mannose-1-P

    GDP-Glucose

    TDP-Glucose

    UDP-Galactose

    Galactose-P

    Glucose-1-P

    Glucose-6-P

    Fructose-6-P

    Fructose-1:6-bis-P

    OH

    H H HO

    HOCH2 C C C C CO

    OH OHH OH

    H HO

    HOCH2 C C C CO CO

    OHH

    H

    OH H

    C C

    OH

    CO

    P-Ribosylamine

    Glycerate2, 3-Diphospho-glycerate

    3-P-Glyceraldehyde

    1:3-bis-P-Glycerate

    3-P-Glycerate

    2-P-Glycerate

    P-enolpyruvate

    Inositol

    CH OH2

    CH OH2

    HOCH

    CH OH2

    CH O2

    HOCHP

    Glycerol

    UDP-GalactoseUDP-Sugars

    CH CH OH3 2ETHANOL

    Dihydroxy-acetone-P

    (Glycerone-P)

    Glucosamine-6-P

    Phospho-serine

    Chain elongation Mitochondrial

    Serine

    Serine

    Indole-3-glycerol-P

    3-Deoxy-D-arabino-heptulosonate-7-P

    Indoleacetate(Auxin)

    Indoxyl

    Formylkynurenine Kynurenine 3-Hydroxykynurenine

    3-Hydroxyanthranilate

    2-Amino-3-carboxymuconate semialdehyde

    NH

    OH

    Tryptamine 1-(o-Carboxy phenylamino)1-deoxyribulose-5-P

    N-(5-P-Ribosyl)anthranilate

    Anthranilate

    Catechol

    NHIndole-

    acetaldehyde

    NH

    CH CHO2

    Indolepyruvate

    NH

    C-CH(OH)CH(OH)CH O2 PCH

    2-Aminomuconate-6-semialdehyde

    CH CH NH2 2 2

    NH

    1.2.3.7

    4.1.1.43

    3.5.1.9 3.7.1.3

    4.2.1.20

    1.13.11.6 4.1.1.45

    2.4.2.18

    4.6.1.4

    4.1.1.48

    1.14.13.9

    4.6.1.3 Dehydro-quinate

    4.2.1.10 1.1.1.25 2.5.1.19Shikimate-3-P Shikimate-5enolpyruvate 3-P

    ChorismatePEP

    2.7.1.71

    1.4.1.19

    Homogentisate Phenylpyruvate

    Cinnamate

    Coumarate

    Prephenate

    2-Aminomuconate

    Fumarate Aspartate

    GLYCINE

    Sarcosine

    Hydroxy-pyruvate

    P-Hydroxy-pyruvate

    SERINE

    Imidazoleglycerol-P

    P-Ribosyl-ATP P-Ribosylformimino5-aminoimidazole-carboxamide-R P

    Formiminoglutamate

    Imidazolonepropionate

    Urocanate

    Cystathionine Homocysteine

    Phosphoadenylyl-sulphate

    (PAPS)

    CH (NH )COOH2 3+

    Histidinol-PHistidinolHistidinal3.1.3.15 2.6.1.91.1.1.23

    3.6.1.315.3.1.162.4.2.17

    Asparagine

    ALANINE

    3-Sulphinylpyruvate

    Oxobutyrate

    2-Aceto-2-hydroxy-butyrate

    O-Phospho-homoserine

    HO SCH CH NH2 2 2 2Hypotaurine

    HO SCH CH NH3 2 2 2Taurine

    Glutamate

    -Glutamylcysteine

    Glutathione

    Glycine

    Cysteine

    -Alanine

    Cysteate S-Adenosylhomocysteine

    4.2.99.2

    1.1.1.864.2.1.9

    1.1.1.86 4.2.1.92.6.1.32

    4.1.3.18

    S-Adenosylmethionine

    (SAM)

    2-Methylaceto-acetyl-CoA

    2-Acetolactate 2-3-Dihydroxyisovalerate

    2-Oxo-isovalerate

    3-Hydroxy-isobutyrate

    3-Hydroxy-Isobutyryl-CoA

    Methylacrylyl-CoA

    2-Methyl-3-hydroxy-

    butyryl-CoA

    Tiglyl-CoA 2 Methylbutyryl-CoA

    2:3-Di-OH-3-methylvalerate

    2-Oxo-3-methylvalerate

    Isobutyryl-CoA

    Cysteinesulphinate

    4.2.99.9

    2-Isopropyl-malate

    CH CH COCOO3 2

    +CH CH(NH )COO3 3

    CH CH(OH)COO3

    HO SCH COCOO2 2

    OCH COCOO2P

    OCH CH(NH )COO2 3P

    HOCH COCOO2

    HOCH CH(NH )COO2 3+

    +

    OH

    CH COCOO2

    COO

    OHOHO

    COO

    OHOH

    HO P

    COO

    OHOH

    O

    CH2

    P

    COO

    O-C-COOOH

    OOH

    OOC CH COCOO2

    N H

    HOC-CH(OH)CH(OH)CH 2OPCH

    COO

    NH2

    COO

    OHNH2COO

    COO

    OCH

    OOCCH NHCH2 3

    CH (CH ) COS-ACP3 2 14 CH (CH ) COSCoA3 2 14

    CH (CH ) CH=CHCO-S-ACP3 2 2

    CH CH=CHCO-S-ACP3 CH CH(OH)CH COS-ACP3 2

    COSCoA

    Linoleate

    Oleoyl-CoA

    Stearoyl-CoA Dehydrostearoyl-CoA OH-Stearoyl-CoA Oxostearoyl-CoA

    Palmitoyl-ACP Palmitoyl-CoA

    ACYL-ACP 2, 3-Enoyl-ACP

    3, 4-Decenoyl-ACP

    2, 3-Decenoyl-ACP

    3-OH-Acyl-ACP 3-Oxoacyl-ACP

    3-Oxo-Decanoyl-ACP

    3-Oxo-Hexanoyl-ACP3-OH-Hexanoyl-ACP2, 3-Hexenoyl-ACP

    Butanoyl-ACP Crotonoyl-ACP 3-OH-Butanoyl-ACP Acetoacetyl-ACP

    Hexanoyl-ACP

    3-OH-Decanoyl-ACPDecanoyl-ACP

    Palmitoleoyl-ACP

    -Linolenate Arachidonate Leukotriene B4

    COSCoA

    CO-S-ACP

    Thromboxane B2

    HOOCCH CO-S-ACP2Malonyl-ACP

    HOOCCH CO-SCoA2Malonyl-Co-A

    CH CO-S-ACP3Acetyl-ACP

    CH O-CO-R2

    CH OH2

    R-CO-OCH

    FATTY ACIDACYL-CoA(Cytosol)

    CH O-CO-R2

    CH O2

    R-CO-OCH

    P

    Cardiolipin P