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. . . ChUO1lg 1PHUC CHAT -NGUYENTU TRUNG TAM - PH6I TU

. 1.1. PHI1C CHAT vA sl! TAO THANH PHI1C CHAT

1.1.1. Di~n m(;locua hoa hQc phuc chat ngay nay

1.1.2. MQt s6 khai ni~m ca ban thee IUPAC

1.1.3. Thuyet axit-baza Liuyt va Sl;Tt(;lOphuc

1.2. NGUYtN TO'TRUNGTAM(] PHI1CCHATDONNHAN,PHI1CCHATDANHANvA PHI1CCHATCHaM

1.2.1. Phuc chat dan nhan

1.2.2. Phuc chat da nhan

1.2.3. Phuc chat chum

1.2.4. Phuc chat chum kiriJ.IO(;liva h(;ltllano

1.2.5. Lien kef kim IO(;li- kim 10(;lia phuc chum1.3.PH61TO'

1.3.1. Ph6i tir va nguyen tir cho1.3.2. Ph6i tu khep vang (chelatingligand)

1.3.3. Ki hi~u va ten gQiph6i tu

1.3.4. Ph6i tu kinh di~n va kh6ng kinh di~n

1.3.5. Ph6i tu (j-cho/7t-nh~n1.3.6. Ph6i tir cho (j,7t-cho/7t-nh~n

. ChUO1lg2

PHUONG PHAp T6NG HQP PHUC CHAT

2.1.T6NGHQPPHlJCCHATTUKIMLOAI2.1.1. Tac dlfng cua kim lo(;liv6'ichat oxi boa va chat t(;lOphuc2.1.2. Tac d':lngcua kim lo(;livm ph6i tir

3

11

11

1114

if6--I,

26

26

28

31

35

38

45

45

47 ,49

60

63

69

79

79

80

82

2.1.3. Th,!c h~mh t6ng hqp phuc chat tit kim IOi;\i 85

2.2. TONGHQPPHaC CHATTC!cAc HQPCHATDONGlAN COAKIM LOAI 87

2.2.1. T6ng hqp cac phuc chat axido 87

2.2.2. T6ng hqp phuc chat ammiacat va phuc chat aminat 90

2.2.3. Phuc cabonyl va phuc photphin b~c ba 91

2.2.4. T6ng hqp phuc chat vai phoi tit khep vong . 932.2.5. Th,!c hanh t6ng hqp phuc chat tit cac hqp chat dO'11gian cua kim lo~i 104

2.3. TONGHQPPHaC CHATNHOPHANaNG THAYTH~ PH61n1 107

2.3.1. T6ng hqp phuc chat d,!a vao day ho~t dQng phoi trf 107

2.3.2. T6ng hqp phuc chat d,!a vao day anh hubng trans 108

2.3.3. Thay the phoi tit nha hi~u lIng phoi trf vong 112

~.3.4. Th,!c hanh t6ng hqp phuc chat nha phan lIng thay the phoi tit 113

2.4. TONGHQPPHaCCHATNHOPHANaNGOXIHoA-KHO'PHaCCHAT 118

2.4.1. PhuO'11gphap oxi boa - cQng 118

2.4.2. PhuO'11gphap khit phuc chat 123

2.4.3. PhUO'11gphap di~n hoa t6ng hqp phuc chat 124

. 2.4.4.Th,!chanh t6ng hqpphucchatnha phanlIngoxi boa -khitphucchat 1252.5.DUNGMOlTRONGTONGHQPPHac CHAT 127

2.5.1. Cau truc chat long 1282.5.2. Phan Iq~i dung m6i 130

2.5.3. Momen lu&1gc,!c va hang so di~n m6i 136

2.5.4. S,! sonvat boa va phuc dung m6i 1382.5.5. Tfnh tan cua phuc chat 143

2.5.6. T6ng hqp phuc crat trong dung m6i khac nuac 145

Chuang 3PHUONG PHAp xAc DfNH THANH PHAN CUA PHUC CHAT 148

3.1. PHUONGPHApHoA HQC

3.1.1. Xac dinh ham luqng nguyen to3.1.2. Xac dinh ham luqng nuac ket tinh

3.1.3. Dinh tfnh ion bang phan lIng d~c trung

3.2.PHUONGPHApDODODANDI~NCOADUNGD!CHPHaCCHAT3.2.1. DQdan di~n phan tit3.2.2. Cac yeu to chi phoi dQdan di~n phan tit

3.3: PHUONGPHApPHANTfcH NHI~T

148

148

151151

152

152153156

3.3.1. Co soli thuyet phuong phap phan tich nhi~t

3.3.2. Phan ling dehidrat h6a boi nhi~t3.3.3. Phan ling deacvo h6a

3.3.4. Phan ling tach hidrohalogenua3.3.5. Sl!d6ng phan h6a boi nhi~t3.3.6. Phan ling tach cac phoi ttr khac

Chuang 4PHUONG PHAp PHO HAP THt,J ELECTRON

4.1. BaG XA vA sV HAP THV BaG XA

4.1.1. Buc X(;ldi~n tu

4.1.2. D!nh lu~t hap thlJ buc X(;l

4.1.3. Chuy~n rnuc electron va quy lac chQn lQc4.2. GHIvA BI~U DI~N PH6 Tlf NGO~I- KHAKI~N

i4.2.UGhi ph6 ttr ngo(;li- kha kien (UV - Vis).4.2.2. Bi~u di~n ph6 ttr ngo(;li- kha kien

4.2.3. Cac thu~t ngii thuemg dung4.3.PH6 'd.d

I ------

4.3.1. Ph6:chuy~n d-d va thuyet truemgphoi ttr4.3.2. Gian d6 Orgel va gian d6 Tanabe-Sugano

4.3.3. Ghi.va phan tich ph6fcl;~y~~d~du~~aphuc chat4.4. PH6 GHUY~NDI~NTfcH' -- --

4.4.1. Chuy~n rnuc kern chuy~n di~n tich4.4.2. Ghi va phan tich ph6 chuy~n di~n tich cua phuc chat

4.5. PH6 PH61Tlf

4.5.1. Khai ni~rn v6 ph6 phoi ttr

4.5.2. Hap thlJ ttr ngo(;li- kha kien cua cae hqp chat vo co don gian

4.5.3. Hap thlJ ttr ngo';li- kha kien eua cae hQ'pchat hiiu co don gian4.5.4. Ghi va phan tich ph6 phoi ttr eua phue chat

Chuang 5PHUONG PHAp PHO DAO DONG,

5.1. DAO DONG COA PHAN Tlf vA SV HAP THV BaC XI:. H6NG NGO~I

5.1.1. Dao dQng cua phan ttr hai nguyen ttr

156163167171176179

187

187187

188189

191191

193195

195

195

198203

212212

215218

218

219

221

228

233

233

233

5.1.2. Dao dQng cua phan tit nhi~u nguyen tit

5.1.3. Ph6 khuech tan t6 h<JP(ph6 Raman).5.2. GHI vA BI~U DI~N PH6 H6NG NGO~I

5.2.1. Ghi ph6 h6ng ngol;li

5.2.2. Bi~u di~n ph6 h6ng ngol;li5.3. H~P THU H6NG NGOAICOAcAc HOP CH~T vC CO vA PH(fc CHAT. .' . .

5.3.1. Bi~u d6 tucmg quan5.3.2.Ph6 daDdQngva cilutruc h<JPchillvo co .

5.4. HAPTHl) H6NG NGO~ICOAcAc HQPCH~THau CO

5A.l. Tan so di[lctrung nh6m5A.2. Tan so hilp th1;1cua cac lien ket dcmv6'ihidro

5A.3. Tan so hilp th1;1cua cac nh6m lien ket ba va lien ket doi lien5AA. Tan so hilp th1;1cua nh6m cacbonyl5A.5. Tan so hilp th1;1cua cac lien ket doi C=C, C=N, N=N va N=O

5A;6. Hilp th1;1trong vung van ng6n tar5A.7. Vi d1;1phan rich ph6 IR h<JPchill hfiu co

5.5. PHANTfcH PH6 DAOBONG cAc HQP CHATPH(fC CHAT

5.5.1. Anh huang cua sg tl;lOphuc den cac van ph6 h6ng ngol;licuaphoi tit

. 5.5.2. Ph6 daDdQngcua day phuc chill cis-diamin khong thuancua Pt(II)

5.5.3. PM.n rich ph6 h6ng ngol;licua phuc chilt. _Lkim IOl;li

chuy~n tiep v6'iaxil cacboxylic5.5A. Ph6 daDdQng cua day pbuc chill trans-dic1oro

(metyleugenol)(amin) Pt(II)

ChUO1lg 6

PHUONG PHAp PH6 CQNG HUONG TiT H~ T NHA.N

6.1.SPINH~T NHANvA CONGHUaNGTUH~T NHAN6.1.1. Spin hl;ltnhan va dieu ki~n cQnghuang

6.1.2. Ghi ph6 cQnghuang tit hl;ltnhan6.2.BOCHUY~ND!CHHoA HQC

6.2.1. Dinh nghia

6.2.2. Cac yell to nQiphan tit anh huang den'dQchuy~n dich h6a hQc

6.2.3. Hl;ltnhan tucmg ducmgve dQchuy~n dich h6ahQc

235236

240240242244

244247

249250251254

256260262

263266

266

273

283

289

295

295

295

298

299

299301

306

6.2.4. Cac yell t6 ng6'.liphan fir anh hubng den dQchuy~n d!ch boa hQc 308 .

6.3. TlJONGTAc SPIN-SPIN 311,

6.3.1. Ban chill cua tu<mg lac spin-spin 311

6.3.2. Hang s6 tuang lac spin-spin (hang s6 tach) 315- 6.4. PHO 1HNMRvA 13CNMRCOAHOP CHft:THatJ CO 317

6.4.1. DQchuy~n d!ch ho~ hQec'uapr~ton .. 3176.4.2. CucmgdQvan ph6 eQnghubng tu proton 3206.4.3. Sl;ltach van ph6 do tuang lac spin-spin giua cae proton 3216.4.4. Ph6 l3c NMR cua hqp chill hUllca 327

6.5.PHANTfcHPHO1HMNRCOAPHaCCHft:T 330

6.5.1. Ph6 IH NMR eua day phue eMitci.U[~~~2(~orpholi~)(Amin)f 3316.5.2. Ph6 IH NMR cua day phue chill cis-[PtCliPiperidin)(Amin)] 340

6.5.3. Ph6 IH NMR eua phuc chill kim IO'.livui olephin 349

6.5.4.Ph61H NMR ~~a ~hu~hid~~~ va~phucvui ph6i tir 7t-giai loa _6phuc! J3~6.6.PHANTfCHPHO13CN-MRCOAcACPHacCHft:T - 359

6.6.1. Tin hi~u l3CNMR eua cacbon 6 ph6i fir eaebonyl 360

6.6.2. Tin hi~u l3CNMR cua caebon 6 ph6i firvui h~ electron 7tgiai loa 360

6.6.3.Tin hi~uBCNMRcua eacbon6 ph6i firankyl va 1l2-olephin 3626.7.PHOGONGHUaNGT(fH~TNHANHAlCHI~UvAcft:uTROCCOAPHaCCHft:T364

6.7.1. Ph6 HMQC 3656.7.2. Ph6 HMBC 3686.7.3. Ph&'NOESY 371

6.8.PH61HQPcAcPHUONGPHApPHONGHI~NcOUcft:uTROCPHaCCHft:T 3746.8.1. Quy kef tin hi~u NMR 6 nhiIng ph6i fir phuc t'.lP 374

'6.8.::2::Xacd!nh cilu true khong gian cua phuc chill[PtCli arylo1ephin)(amin)] 375

Chuang 7PHUONG PHAp PHO KH6I LUQNG

7.1.PHUONGPHApPHOKH61LUQNGIONHoAELECTRON(EI MS)

7.1.1. Sl;lt'.l° thanh ion phan firva ion manh

7.1.2. May ph6 kh6i Iuqng

7.1.3. Cach bi~u di~n ph6 kh6i Iuqng

7.2.£>6NGV!TRONGPHUONGPHApPHOKH61LUQNG

380

380380383384385

7.2.1. Bi~u hi~n eua cae d6ng vi tren ph6 kh6i luqng

7.2.2. Ph6 kh6i luqng phan giii eao

7.3. MOTs6 O'NGDVNGCOAPHOEI MS

7.3.1. Xac dinh nguyen fir kh6i va phan fir kh6i

7.3.2. XiStdoan eifu true phan fir

7.3.2. Xae dinh nhi~t thang hoa

7.4. PHllONGPHAp PHOKH61LllQNG IONHoA a Ap SUATKHfQUY~N

(APIMS)7.4.1. 51!hoa hO'iion

7.4.2. 51!t<;tothanh ion

7.4.3. Biy ion va phuO'ngphap M5n

7.4'.4. Ph6i hqp cae phuO'ngphap ph6 xae dinh eifu true phue ehift

385

387

389389

390

395

395

395

396

399

402

TAI LI~U THAM KHAo 414