1

Dr. Anjani Kumar Tiwari Associate Professor

Department of C

School of Physical and Decision Sciences

Mob No.: 7503381343

Email:anjanik2003@gmail.com

Webpage: http://www.bbau.ac.in/dept/DAC/DRANJANI.pdf

https://scholar.google.com/citations?user=JNL2RvMA

Academic Identity:

Orcid Id 0000-0001-6271-3055

Web of Science Researcher ID(Publons and Web of Science) AAG-6558-2019

Scopus Id 14046193800

Google Scholar Id JNL2RvMAAAAJ&hl

Microsoft Acdemic Search ID 2170053171

Education Qualification

Organization Year of award

Graduation University of Lucknow,

Lucknow 1997

Post-graduation University of Lucknow,

Lucknow 1999

Ph.D. University of Lucknow,

Lucknow 2006

Post-Doctoral Training National Institute of

Radiological Sciences,

Chiba, Japan

2013

Professional Experience (In Years)

Teaching Experience: 10

Research Experience: 18

Areas of Research

Chemical Kinetics

Radiochemistry

Chemical biology

Chemoinformatics (CADD)

Radiopharmaceuticals & Biomedical Imaging (PET/SPECT/MRI )

Recent

Photograph

.

.

Work History

Associate Professor, Department of Chemistry

Babasaheb Bhimrao Ambedkar University, Lucknow, Utter Pradesh

•Working as a team leader for the project Luminescent nanoprobe for molecular

recognition of the translocator protein (TSPO) and Develoment of probes for

P2X7/P2Y12R (purinergic receptors) to understand the microglial activation during

neuroinflammation

Tried to create positive/safe learning environment in our classrooms and labs by

setting and enforcing code of conduct.

Advised our student groups, assisting for educational programs both on and off the

main campus.

Mentored our PG/M.Phil/Ph.D. students, including directing research,

projects/internships, as well as advising on their career prospects.

Commissioned Visiting Researcher

National Institutes Of Radiological Sciences, Inage-ku, Chiba-shi, 263-8555,

Japan

Worked with Senior Researchers/PIs to coordinate qualitative research into PET

Radiochemistry for specific neuro targets.

Scientist

Institute of Nuclear Medicine & Allied Sciences, DRDO, Delhi

Use of Chemoinformatics (LBDD/SBDD)/ bioinformatics tools for screening of

new drug candidates.Synergic effect of animal (PET/SPECT) & MRI during study

of neuro- targets

Structural\ thermodynamic and selectivity properties of the linear and open

chain polyaminocarboxylates (Kinetic and mechanistic study)

Liaised with national and international governing bodies like ICMR/IAEA/JSPS to

highlight technologies and advancements in research.

Authored 80 technical documents outlining research processes, findings and

their applications for human health.

JSPS Invited Researcher (long term invitation)

Japan Society For The Promotion Of Science (JSPS), Inage, Chiba, Japan

Worked for the development and quantification of probes for 18 kDa Translocator

Proten,serotonin 5- HT7receptor and phosphodiesterase 10 in brain

IAEA (UN) Fellow, (Selected candidate from Asia Oceania region),

International Atomic Energy Association, UN

Advance training in PET radiochemistry for neuroimaging

After this advance training i

1) was able to operate automated radiochemistry synthesizer.

2) Have practical knowledge of PET probe production and quality control.

3) was able to do animal PET study for basic evaluation of PET-RP candidate.

2018-01 - Current

2018-04 - 2022-03

2003-03 - 2018-01

2014-04 - 2015-03

2013-04 - 2013-09

2

Research/Consultancy Grants

Title of Projects Funding

Agency Duration

(Specific Dates)

Total grant Role (PI/CO-

PI)

Acetamido -benzoxazolones as a

specific marker for translocator

protein, DRDO(TD/16-17/INM-321

DRDO 4 Years

(2017-21)

Completed

42 Lakhs PI

Luminescent nanoprobe for

molecular recognition of the

translocator protein (TSPO)

BT/PR29449/NNT/28/1572/2018

DBT 3 Years

(2019-22)

70.25

Lakhs

PI

RD-P1-2003/INM-302 (2003-2005)

Radiocomplexation of anti-infective

drugs and their evaluation as

specific infection imaging agent

DRDO 2003-05 0.8 Crore Co-PI

RD-P1-05/INM-306 (2005-2008)

Development of

radiopharmaceuticals/magnetophar

maceuticals and its evaluation for

molecular imaging and therapy.

DRDO 2005-08 1.9 Crore Co-PI

RD-P1-08/INM-311(3.1) (2009-14)

Development of molecular imaging

agents and enhancers for armed

forces

DRDO

2009-14

2.5 Crore

PI

Development and quantification of

pet ligands for serotonin 5-

ht7receptor and phosphodiesterase

10 in brain

JSPS 2014-15 4.5 Million

Yen

Co-PI

RD-TP-15-16/INM (2015-2016)

Synthesis and evaluation of

acetamida-benzoxazolnederivatised

N3 system to determine TSPO/PBR

[18 kda] expression in

stroke/trauma like

neuroinflammatory brain conditions

INMAS,

DRDO

2015-16 0.10 Crore PI

2

Publications

International 2021

1- Anupriya Adhikari, Priya Singh, Kamalesh S Mahar, Manish Adhikari, Bhawana Adhikari, Ming-Rong Zhang and Anjani K Tiwari*. Mapping of Translocator Protein (18 kDa) in Peripheral Sterile Inflammatory Disease and Cancer through PET Imaging. Molecular pharmaceutics. 2021, (manuscript ID: mp-2021-00002w),Just accepted, ISSN No 1543-8392.

2- Anupriya Adhikari, Anwesh Pandey, Devesh Kumar and Anjani Kumar Tiwari*. Determination of Hybrid TSPO Ligands with Minimal Impact of SNP (rs6971) through Molecular Docking and MD Simulation Study. Letters in drug design & discovery, 2021, (manuscript ID: BMS-LDDD-2020-294), In-proof ISSN No.1875-628X.

3- Pooja, Deepika Singh, Swati Aggarwal, Vinay Kumar Singh, Ramendra Pratap, Anil Kumar Mishra, Anjani Kumar Tiwari, ‘Lanthanide (Ln3+) complexes of bifunctional chelate: Synthesis, physicochemical study and interaction with human serum albumin (HSA)’, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 244, 118808, ISBN No. 1386-1425,

2020

4- Raunak Varshney, Puja P. Hazari, Anjani K Tiwari, Rashi Mathur, Aruna Kaushik, Meenakshi Saklani, Sweta Singh, Ankur Kaul, Roger Stromberg, Anil K.Mishra, ‘Synthesis and Biological Evaluation of Modified Laminin Peptide (N2S2 - KDP) with enhanced affinity for Neuronal Growth and Targeted Molecular Imaging (SPECT)’, Bioorganic Chemistry, 2020, 104516, ISBN No. 0045-2068.

5- Raunak Varshney, Ajay Chitkara, Meenakshi Saklani, Amritjyot Kaur, Rashi Mathur, Anjani Tiwari, Baljinder Singh, Anil K Mishra,‘Targeting Bombesin Peptide Receptors for Cancer Imaging: Perspective in Prostate, Lung and Breast Cancer’, Bioorganic Chemistry, 2020, 104516, ISBN No. 1386-1425.

6- Mohd. Faheem, Anjani K. Tiwari, Vinay K. Singh*, ‘A Review on Modern Synthetic Route fothe Construction of 1, 3-Diazanaphthalene Moiety’ Current Organic Chemistry, 2020, 24, Pages1108-1138 ISSN (Online): 1875-5348.

7- Mohd Faheem, Anjali Rathaur, Apoorva Pandey, Vinay Kumar Singh, Anjani K Tiwari, ‘A Review on the Modern Synthetic Approach of Benzimidazole Candidate, Chemistry Select, 2020, 5, 3981-3994, Online ISSN:2365-6549.

8- Anjani Kumar Tiwari*, Yiding Zhang, Tomoteru Yamasaki, Neelam Kumari, Masayuki Fujinaga, Wakana Mori, Akiko Hatori, Nobuki Nengaki, Anil Kumar Mishra, Hong Zhang, Ming-Rong Zhang, ‘Radiosynthesis and evaluation of acetamidobenzoxazolone based radioligand [11C] N′-MPB for visualization of 18 kDa TSPO in brain,’ New Journal of Chemistry, 2020, 44, 7912-7922, ISSN 1369-9261.

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9- Nidhi Chadha, Dushyant Singh, Marilyn D Milton, Gauri Mishra, Joseph Daniel, Anil K Mishra, Anjani K Tiwari*, ‘Computational prediction of interaction and pharmacokinetics profile study for polyamino-polycarboxylic ligands on binding with human serum albumin,’ New Journal of Chemistry,’ 2020, 44, 2907-2918, ISSN 1369-9261.

2019 10- Anupriya Adhikari, Anjani K Tiwari, Abha Shukla, Anil K Mishra, Anupama Datta,

‘Synthesis and Preclinical Evaluation of Radioligand, 99mTc‐DO3A‐Et‐RPAR for Imaging NRP‐1 Specific Tumor,’ Chemistry Select, 2019, 4, 12950-12954, ISSN 1369-9261.

11- P Srivastava, D Kakkar, P Kumar, AK Tiwari*,’ Modified benzoxazolone (ABO‐AA) based single photon emission computed tomography (SPECT) probes for 18 kDa translocator protein,’ Drug development research, 2019, 80,6, 741-749, ISSN 1098-2299

12- Pooja Srivastava, Neelam Kumari, Dipti Kakkar, Ankur Kaul, Pravir Kumar, Anjani K Tiwari*, ‘Comparative evaluation of 99m Tc-MBIP-X/11 [C] MBMP for visualization of 18 kDa translocator protein’, New Journal of Chemistry, 2019,43, 11288-11295.

2018

13- AK Tiwari, N Kumari, AK Mishra,’ Evaluation Of Arylpiperazinyl Derivatised Benzoxazolone And Benzothiazolone For 5-HT7 Expression In Brain,’ European journal of nuclear medicine and molecular imaging, 2018, 45, S671-S671.

14- Kanchan Chauhan, Anjani K Tiwari, Nidhi Chadha, Ankur Kaul, Ajai Kumar Singh, Anupama Datta, ‘Chalcone Based Homodimeric PET Agent, 11C-(Chal)2DEA-Me, for Beta Amyloid Imaging: Synthesis and Bioevaluation’ , Molecular pharmaceutics, 2018, 15, 1515-1525.

15- Shivani Singh, Sweta Singh, Anjani Kumar Tiwari, Rakesh Kumar Sharma, Rashi Mathur, Ankur Kaul, ‘A Novel 18F Labelled Imidazo-oxazolopyridine Derivative as β-Amyloid Imaging Agent: Synthesis and Preliminary Evaluation,’ Asian Journal of Chemistry, 2018, 30, 183-190.

2017

16- Mallika Pathak, Himanshu Ojha, Anjani K Tiwari, Deepti Sharma, Manisha Saini, Rita Kakkar, ‘Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2, 4, 6-s-triazine,’ Chemistry Central Journal, 2017, 11, 1-11.

17- N Kumari, S Bhagat, AK Tiwari, ‘Evaluation of benzoxazolone based TSPO selective PET radiotracer to access microglial activation in ishemic rat brain,’ European Journal Of Nuclear Medicine And Molecular Imaging, 2017, 44, S533-S533.

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18- AK Tiwari,’ Evaluation of arylpiperazinyl analogues as PET radioligand for 5HT7, ‘

European Journal Of Nuclear Medicine And Molecular Imaging’, 2017, 44, S534-S535.

19- Neelam Kumari, Nidhi Chadha, Pooja Srivastava, Lokesh Chandra Mishra, Sunita Bhagat, Anil K Mishra, Anjani K Tiwari, ‘Modified benzoxazolone derivative as 18‐kD a TSPO ligand,’ Chemical biology & drug design 2017, 90, 511-519.

20- Anupriya Adhikari, Neelam Kumari, Manish Adhikari, Nitin Kumar, Anjani K Tiwari, Abha Shukla, Anil K Mishra, Anupama Datta. Zinc complex of tryptophan appended 1, 4, 7, 10-tetraazacyclododecane as potential anticancer agent: Synthesis and evaluation. Bioorganic & medicinal chemistry, 2017, 25, 3483-3490 (ISSN: 0968-0896 )

21- Shweta Dumoga, Yogesh Rai, Anant Narayan Bhatt, Anjani Kumar Tiwari, Surendra Singh, Anil K Mishra, Dipti Kakkar. Block copolymer based nanoparticles for Theranostic intervention of cervical Cancer: Synthesis, pharmacokinetics, and in vitro/in vivo evaluation in HeLa xenograft models. ACS applied materials & interfaces. 2017, 9, 22195-22211 (ISSN No. 1944-8252 )

2016

22- Sandhya Rangaswamy, Raunak Varshney, Anjani K Tiwari, Swarndeep K Sethi, BS Hemanth kumar, Himanshu Ojha, Sandeep Kaur‐Ghumaan, Anil K Mishra. Gd (III)‐DO3A‐SBMPP: An Effort to Develop the MRI Contrast Agent with Enhanced Relaxivity. ChemistrySelect, 2016, 1, 6206-6211 (ISSN No. : 2365-6549)

23- Sweta Singh, Anjani K Tiwari, Raunak Varshney, R Mathur, Gauri Shukla, N Bag, B Singh, Anil K Mishra. Comparative evaluation of Bis (thiosemicarbazone)-Biotin and Met-ac-TE3A for tumor imaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2016, 153, 566-571 (( ISSN No.: 1386-1425)

24- Raunak Varshney, Swarndeep K Sethi, Sandhya Rangaswamy, Anjani K Tiwari, Marilyn D Milton, Senthil Kumaran, Anil K Mishra. Design, synthesis and relaxation studies of triazole linked gadolinium (III)–DO3A-BT-bistriazaspirodecanone as a potential MRI contrast agent. New Journal of Chemistry, 2016, 40, 5846-5854

2015

25- Swati Aggarwal, Deepa Sinha, Anjani Kumar Tiwari*, Pooja Pooja, Ankur Kaul, Gurmeet Singh, Anil Kumar Mishra. Studies for development of novel quinazolinones: new biomarker for EGFR. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015, 143, 309-318 ( ISSN No.: 1386-1425)

26- Anjani K Tiwari, Masayuki Fujinaga, Katsushi Kumata, Yoko Shimoda, Joji Yui, Tomoteru Yamasaki, Lin Xie, Akiko Hatori, Masanao Ogawa, Kazunori Kawamura, Ming-Rong Zhang. Synthesis and evaluation of two novel F-18-labeled acetamidobenzoxazolone radioligands for PET imaging of translocator protein (18

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kDa). journal of labelled compounds & radiopharmaceuticals, 2015, 58, S154-S154 (ISSN No. 1099-1344).

27- Nidhi Chadha, Anjani K Tiwari*, Vikas Kumar, Sangeeta Lal, Marilyn D Milton, Anil K Mishra. Oxime-dipeptides as anticholinesterase, reactivator of phosphonylated-serine of AChE catalytic triad: probing the mechanistic insight by MM-GBSA, dynamics simulations and DFT …. Journal of Biomolecular Structure and Dynamics. 2015, 33, 978-990 (ISSN No.0739-1102 )

28- Nidhi Chadha, Anjani K Tiwari*, Vikas Kumar, Marilyn D Milton, Anil K Mishra. In silico thermodynamics stability change analysis involved in BH4 responsive mutations in phenylalanine hydroxylase: QM/MM and MD simulations analysis. Journal of Biomolecular Structure and Dynamics. 2015, 33, 573-583, (ISSN No.0739-1102 ).

29- Nisha Saini, Raunak Varshney, Anjani K Tiwari*, Ankur Kaul, MPS Ishar, Anil K Mishra. Design, synthesis and biological evaluation of coumarin coupled nitroimidazoles as potential imaging agents. RSC advances. 2015, 5, 97102-97112 (ISSN 2046-2069)

30- Ankur Kaul, Anjani K Tiwari*, Raunak Varshney, Anil K Mishra. Synthesis, in silico screening and preclinical evaluation studies of a hexapeptide analogue for its antimicrobial efficacy. RSC Adv., 2015, 5, 97180-97186 (ISSN 2046-2069)

31- Raunak Varshney, Sweta Singh, Anjani K Tiwari, Rashi Mathur, Shivani Singh, Puja Panwar, Neelam Yadav, Krishna Chutani, B Singh, Anil K Mishra. Comparison of BTSE-RGD with DOTA-RGD as a potential imaging agent for tumors. RSC Advances, 2015, 5, 54439-54445 (ISSN 2046-2069)

32- Anjani K Tiwari, Joji Yui, Yiding Zhang, Masayuki Fujinaga, Tomoteru Yamasaki, Lin Xie, Yoko Shimoda, Katsushi Kumata, Akiko Hatori, Ming-Rong Zhang. [18 F] FPBMP:–a potential new positron emission tomography radioligand for imaging of translocator protein (18 kDa) in peripheral organs of rats. RSC advances, 2015, 5, 101447-101454 (ISSN No. 41977-41984)

33- AK Tiwari, J Yui, S Aggarwal, T Yamasaki, L Xie, N Chadha, Y Zhang, M Fujinaga, Y Shimoda, K Kumata, AK Mishra, M Ogawa, M-R Zhang. Design, synthesis and biological evaluation of small molecule-based PET radioligands for the 5-hydroxytryptamine 7 receptor. RSC Advances, 2015, 5, 19752-19759 ( ISSN No. 19752-19759)

34- Sweta Singh, Anjani K Tiwari, Raunak Varshney, Rashi Mathur, Puja P Hazari, B Singh, Anil K Mishra. Evaluation of methionine and tryptophan derivatised vehicles: Met-ac-TE3A/Trp-ac-TE3A for tumor imaging. RSC Advances, 2015, 5, 41977-41984 ( ISSN No. 19752-19759)

35- S Aggarwal, AK Tiwari*, V Kumar, R Pratap, G Singh, AK Mishra. Novel pyridinium

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oximes: Synthesis, molecular docking and in vitro reactivation studies. RSC Advances, 2015, 5, 23471-23480 ( ISSN No. 19752-19759)

36- Pooja Srivastava, Ankur Kaul, Himanshu Ojha, Pravir Kumar, Anjani K Tiwari. Design, synthesis and biological evaluation of methyl-2-(2-(5-bromo benzoxazolone) acetamido)-3-(1 H-indol-3-yl) propanoate: TSPO ligand for SPECT. RSC Advances, 2015, 6, 114491-114499 ( ISSN No. 19752-19759)

2014

37- AK Tiwari, M Fujinaga, J Yui, T Yamasaki, L Xie, K Kumata, AK Mishra, Y Shimoda, A Hatori, B Ji, M Ogawa, K Kawamura, F Wang and MR Zhang. Synthesis and evaluation of new 18F-labelled acetamidobenzoxazolone-based radioligands for imaging of the translocator protein (18 kDa, TSPO) in the brain. Org. Biomol. Chem., 2014,12, 9621-9630. (ISSN No.: 1477-0539)

38- AK Tiwari, J Yui, M Fujinaga, K Kumata, Y Shimoda, T Yamasaki, L Xie, A Hatori, J Maeda, N Nengaki, MR Zhang. Characterization of a novel acetamidobenzoxazolone-based PET ligand for translocator protein (18 kDa) imaging of neuroinflammationin the brain. J Neurochem.2014, 129, 712-20. (ISSN No.: 1471-4159)

39- P Singh, S Aggarwal, AK Tiwari*, V Kumar, R Pratap, K Chuttani, AK Mishra. Bis(Methylpyridine)-EDTA Derivative as a Potential Ligand for PET Imaging: Synthesis, Complexation, and Biological Evaluation. Chem Biol Drug Des.2014, 84, 704-711, (ISSN No.:1747-0285).

40- J Tanwar, A Datta, K Chauhan, SS Kumaran, AK Tiwari, KG Kadiyala, S Pal, M Thirumal, AK Mishra. Design and synthesis of calcium responsive magnetic resonance imaging agent: Its relaxation and luminescence studies. Eur J Med Chem. 2014, 82, 225-32, (ISSN No. 0223-5234).

41- P Srivastava, AK Tiwari, D Kakkar, V Singh Rathore, AK Mishra. Bis (histidine) with N2 Vehicle: An Important Skeleton for MR/Chelation Therapy. Chem Biol Drug Des.2014, 83, 682-87, (ISSN No.:1747-0285).

42- MM Husain, Rajeev and AK Tiwari. Natural Bond Orbital (NBO) Analysis and Binding Affinity towards Protein Kinase 2: DFT and Docking Studies of Coumarin Derivatives. ChemSci Trans., 2014, 3, 67-72, (ISSN No. 2278-18).

2013

43- N Saini, R Varshney, AK Tiwari, A Kaul, M Allard, MP Ishar, AK Mishra. Synthesis, conjugation and relaxation studies of gadolinium(III)-4-benzothiazol-2-yl-phenylamine as a potential brain specific MR contrast agent. Dalton Trans. 2013, 42(14), 4994-5003, (ISSN No.:1477-9234).

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44- Pooja Singh, Vikas Kumar, Swati Aggarwal, AK Tiwari, Krishna Chuttani, Ramendra

Pratap and Anil K. Mishra. Design, Synthesis, and Biological Evaluation of Catecholamine Vehicle for Studying Dopaminergic System. Chemical Biology & Drug Design. 2013, 82, 226–232, (ISSN No.1747-0285).

45- N Chadha, AK Tiwari*, V Kumar, MD Marilyn and AK Mishra. Perception into hypoxia selectivity and electronic features of symmetrically substituted bisthiosemicarbazone ligands and their copper complexes: DFT and QM/MM docking ,Med. Chem. Commun., 2013,4, 542-548 (ISSN No.2040-2511) .

46- Vikas Kumar, Nidhi Chadha, Anjani K. Tiwari*, Neeta Sehgal, Anil K. Mishra. Prospective atom-based 3D-QSAR model prediction, pharmacophore generation, and molecular docking study of carbamate derivatives as dual inhibitors of AChE and MAO-B for Alzheimer’s disease, Medicinal Chemistry Research. 2013,23,1114-22, ISSN No. 1554-8120.

47- Pooja Srivastava, Vikas Kumar, Anjani K. Tiwari*, Anil K. Mishra. Quantitative structure activity relationship of tetraazamacrocyclic vehicle DO3A with lanthanide relaxivity and hydrophobicity, Medicinal Chemistry Research.2013, 22, 5861-67, ISSN No. 1554-8120.

48- S Aggrawal, AK Tiwari*, P Srivastava, N Chadha, V Kumar, G Singh, AK Mishra. Investigation for the interaction of tyramine based anthraquinone analogue with Human Serum Albumin by optical spectroscopic technique. ChemBiol Drug Des.2013, 81(3), 343-48, (ISSN No.1747-0285).

49- P Srivastava, AK Tiwari, N Chadha, K Chuttani, AK Mishra, Synthesis and biological evaluation of newly designed phosphonate based bone-seeking agent. Eur J Med Chem. 2013, 65, 12-20 (ISSN No. 0223-5234).

50- Sangeeta Agrawal, R.R Bhatnagar, AK Tiwari and Upasana Sharma, Synthesis, Analytical analysis and medicinal aspect of novel Benzimidazole and their metal complexes. ChemBiol Drug Des.2013, 82(5), 630-34, (ISSN No.1747-0285).

51- Nidhi Chadha, Deepa Sinha, Anjani K. Tiwari, Krishna Chuttani and Anil K. Mishra. Synthesis, Biological Evaluation and Molecular Docking Studies of High-Affinity Bone Targeting N,N'-Bis (alendronate) Diethylenetriamene-N,N'-Triacetic Acid: A Bifunctional Bone Scintigraphy Agent.Chemical Biology & Drug Design. 2013, 82, 468–476, (ISSN No.1747-0285).

2012

52- R Sindhu, AK Tiwari, LC Mishra, MM Husain. Spectroscopic interaction of a coumarin derivative with bovine serum albumin.Cancer Biother Radiopharm. 2012, 27, 452-6, (ISSN No.1557-8852).

53- D Kakkar, AK Tiwari, K Chuttani, A Khanna, A Datta, H Singh, AK Mishra. Design,

8

synthesis, and antimycobacterial property of PEG-bis(INH) conjugates. ChemBiol Drug Des. 2012, 80, 245-53, (ISSN No.1747-0285).

54- PP Hazari, AK Pandey, S Chaturvedi, AK Tiwari, S Chandna, BS Dwarakanath, AK Mishra. Synthesis of oxovanadium(IV) schiff base complexes derived from C-substituted diamines and pyridoxal-5-phosphate as antitumor agents. Chemical Biology and Drug Design .2012, 79, 223-34, (ISSN No.1747-0285).

55- D Kakkar, AK Tiwari, H Singh, AK Mishra. Past and present scenario of imaging infection and inflammation: a nuclear medicine perspective. Mol Imaging.2012, (4), 309-37,ISSN 1536-0121.

56- AK Tiwari*, V Singh Rathore, D Sinha, A Datta, N Sehgal, K Chuttani, AK Mishra. Design and docking studies of [diethylenetriaminepentaacetic acid-(amino acid)2] with acetylcholine receptor as a molecular imaging agent for single-photon emission computed tomographic application. Mol Imaging, 2012, (3), 240-50,ISSN: 1536-0121.

2011

57- AK Tiwari, D Sinha, A Datta, D Kakkar, AK Mishra. Kinetics of formation for lanthanide (III) complexes of DTPA-(me-trp) 2 used as imaging agent. Chemical Biology and Drug Design.2011, 77, 388-92, (ISSN No.1747-0285).

58- AK Tiwari, R Varshney, A Kaushik, A Datta, L Singh, AK Mishra. Correlation of physical parameters during radiochemical synthesis of 18F positron emission tomography radiopharmaceuticals. Cancer Biotherapy and Radiopharmaceuticals. 2011, 26, 389-93, (ISSN: 1557-8852).

59- J Tanwar, A Datta, AK Tiwari, S Chaturvedi, H Ojha, M Allard, NK Chaudary, M Thirumal, AK Mishra. Facile synthesis of non-ionic dimeric molecular resonance imaging contrast agent: Its relaxation and luminescence studies. Dalton Transactions.2011, 40(13), 3346-51, (ISSN No.:1477-9234).

60- J Tanwar, A Datta, AK Tiwari, M Thirumal, K Chuttani, AK Mishra. Preclinical evaluation of DO3P-AME-DO3P: A polyazamacrocyclic methylene phosphonate for diagnosis and therapy of skeletal metastases. Bioconjug Chem. 2011, 22, 244-55, (ISSN No.1520-4812).

61- D Kakkar, AK Tiwari, K Chuttani, R Kumar, K Mishra, H Singh, AK Mishra. Polyethylene-glycolylatedisoniazid conjugate for reduced toxicity and sustained release. Therapeutic Delivery.2011, 2, 205-12 (ISSN : 2041-6008).

62- H Ojha, P Gahlot, AK Tiwari, M Pathak, R Kakkar. Quantitative structure activity relationship study of 2,4,6-trisubstituted-s-triazine derivatives as antimalarial inhibitors of plasmodium falciparum dihydrofolatereductase. Chemical Biology and Drug Design. 2011, 77, 57-62, (ISSN No.1747-0285).

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2010

63- D Kakkar, AK Tiwari, K Chuttani, A Kaul, H Singh, AK Mishra. Comparative evaluation of glutamate-sensitive radiopharmaceuticals: Technetium-99m-glutamic acid and technetium-99m-diethylenetriaminepentaacetic acid-bis(glutamate) conjugate for tumor imaging. Cancer Biotherapy and Radiopharmaceuticals.2010, 25, 645-55, (ISSN: 1557-8852).

64- MM D'Souza, RK Marwaha, R Sharma, A Jaimini, S Thomas, D Singh, M Jain, PJS Bhalla, M Tripathi, AK Tiwari, A Mishra, A Mondal, RP Tripathi. Prospective evaluation of solitary thyroid nodule on 18F-FDG PET/CT and high-resolution ultrasonography. Ann NuclMed .2010, 24, 345-55, (ISSN No.1864-6433).

65- N Kumar, AK Tiwari, D Kakkar, N Saini, M Chand, AK Mishra. Design, synthesis, and fluorescence lifetime study of benzothiazole derivatives for imaging of amyloids. Cancer Biotherapy and Radiopharmaceuticals.2010, 25, 571-5, (ISSN: 1557-8852).

66- V Srivastava, D Sinha, AK Tiwari, H Sharma, R Bala Sharma, VK Singh, AK Mishra. Quantitative structure-activity relationship analysis of 4(3H)-quinazolone derivatives as tyrosine kinase inhibitors by multiple linear regression. Cancer Biotherapy and Radiopharmaceuticals.2010, 25, 559-62, (ISSN: 1557-8852).

67- S Singh, H Ojha, AK Tiwari, N Kumar, B Singh, AK Mishra. Design, synthesis, and in vitro antiproliferative activity of benzimidazole analogues for radiopharmaceutical efficacy.Cancer Biotherapy and Radiopharmaceuticals.2010, 25, 245-50, (ISSN: 1557-8852).

68- A Kaushik, AK Tiwari, R Varshney, L Singh, AK Mishra. Monitoring of radiation levels in medical cyclotron facility measured by a comprehensive computerized monitoring system. Indian J Pure Appl Phys .2010, 48, 790-3, (ISSN No. 0975-1041).

69- S Singh, AK Tiwari, H Ojha, N Kumar, B Singh, AK Mishra. SAR of cu (II) thiosemicarbazone complexes as hypoxic imaging agents: MM3 analysis and prediction of biologic properties. Cancer Biotherapy and Radiopharmaceuticals.2010, 25, 117-21, (ISSN: 1557-8852).

2009

70- AK Tiwari, H Ojha, A Kaul, A Dutta, P Srivastava, G Shukla, R Srivastava, AK Mishra. Quantitative structure-property relationship (correlation analysis) of phosphonic acid-based chelates in design of MRI contrast agent. Chemical Biology and Drug Design.2009, 74,87-91, (ISSN No. 1747-0285).

71- AK Tiwari, New anti tumor agents, NATURE INDIA,283,2009, (ISSN No.1755-3180)

72- D Sinha, G Shukla, AK Tiwari, S Chaturvedi, K Chuttani, H Chandra, AK Mishra. 99mTc-DTPA-amino acids conjugate as specific spect pharmaceuticals for tumor

10

imaging. Chemical Biology and Drug Design.2009, 74, 159-64, (ISSN No.1747-0285).

73- V Srivastava, AM Srivastava, AK Tiwari, R Srivastava, R Sharma, H Sharma, VK Singh. Disubstituted 4(3H) quinazolones: A novel class of antitumor agents. Chemical Biology and Drug Design. 2009, 74, 297-301,(ISSN No.1747-0285)..

74- D Kakkar, AK Tiwari, J Verma, AK Mishra. Kinetic and mechanistic significance of the chemical activation of ciprofloxacin for conjugation chemistry. Int J ChemKinet. 2009, 41, 349-56, (ISSN No.1097-4601).

75- G Shukla, AK Tiwari, D Sinha, R Srivastava, H Cahndra, AK Mishra. Synthesis and assessment of 99mTc chelate-conjugated alendronate for development of specific radiopharmaceuticals. Cancer Biotherapy and Radiopharmaceuticals.2009, 24, 209-14 (ISSN: 1557-8852).

2008

76- D Sinha, AK Tiwari, S Singh, G Shukla, P Mishra, H Chandra, AK Mishra. Synthesis, characterization and biological activity of schiff base analogues of indole-3-carboxaldehyde. Eur J Med Chem .2008, 43, 160-5,(ISSN No. 0223-5234) .

77- G Shukla, AK Tiwari, VK Singh, A Bajpai, H Chandra, AK Mishra. Effect of a novel series of benzothiazolo-quinazolones on epidermal growth factor receptor (EGFR) and biological evaluations. Chemical Biology and Drug Design.2008, 72, 533-9, (ISSN No. 1747-0285).

78- G Shukla, AK Tiwari, N Kumar, D Sinha, P Mishra, H Chandra, AK Mishra. Polyethylene glycol conjugates of methotrexate and melphalan: Synthesis, radiolabeling and biologic studies. Cancer Biotherapy and Radiopharmaceuticals. 2008, 23, 571-9, (ISSN: 1557-8852).

2007

79- AK Tiwari, VK Singh, A Bajpai, G Shukla, S Singh, AK Mishra. Synthesis and biological properties of 4-(3H)-quinazolone derivatives, Eur J Med Chem, 2007, 42,1234-8,(ISSN No. 0223-5234).

80- AK Tiwari, AK Mishra, A Bajpai, P Mishra, S Singh, D Sinha, VK Singh . Synthesis and evaluation of novel benzimidazole derivative [bz-im] and its radio/biological studies. Bioorganic and Medicinal Chemistry Letters.2007, 17,2749-55, (ISSN: 0968-0896).

81- RM Naik, A Srivastava, AK Tiwari, SBS Yadav, AK Verma. Kinetic and mechanistic studies of oxidation of amine-N-polycarboxylates complexes of cobalt(II) by periodate ions in aqueous medium. Journal of the Iranian Chemical Society. 2007,4,63-71, (ISSN No. 1735-2428).

11

2006

82- AK Tiwari, AK Mishra, A Bajpai, P Mishra, RK Sharma, VK Pandey, VK Singh. Synthesis and pharmacological study of novel pyrido-quinazolone analogues as anti-fungal, antibacterial, and anticancer agents. Bioorganic and Medicinal Chemistry Letters.2006, 16, 4581-5, (ISSN: 0968-0896).

2005

83- RM Naik, RK Tewari, PK Singh, AK Tiwari, S Prasad. The mercury(II) catalyzed ligand exchange between hexacyanoferrate(II) and pyrazine in aqueous medium. Transition Metal Chemistry .2005, 30, 968-77, (ISSN No. 1572-901X).

Author/s (Year), Title, Name of Journals, Volume (Issue), Page no. National

2004 1- RM Naik, DD Chaturvedi, N Srivastava, AK Verma, AK Tiwari, A Agarwal Kinetics

and mechanism of pentacyanohydroxoferrate(III) formation from the reaction of [FeL(OH)]2-n complexes with cyanide ions [L n-=trans-1,2-diaminocyclohexanetetraacetic acid (CYDTA) and nitrilotriacetic acid (NTA)]. Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry. 2004, 43(11), 2307-14 (ISSN No. 0975-0975).

Author/s (Year), Title, Name of Journals, Volume (Issue), Page no. Book Chapters Raunak Varshney, Ajay Chitkara Meenakshi Saklani, Amritjyot Kaur, Rashi Mathur, Anjani Tiwari, Baljinder Singh, Anil Mishra, ‘Targeting Bombesin Peptide Receptors for Cancer Imaging : Perspective in Prostate, Lung and Breast Cancer’, Novel Approaches in Cancer Studies 2020, 5, 483-491, ISBN No. 2637-773X. Author/s (Year), Title, Name of Book, Publisher, Edition, ISBN No., Page no. Authored Books Author/s (Year), Title, Name of Book, Publisher, Edition, ISBN No., Page no. Edited Books Author/s (Year), Title, Name of Book, Publisher, Edition, ISBN No., Page no.

Patents

Inventors Title and Award/Application no. Awarded Published

Filed

12

Research Supervision

Completed Ongoing

PG/M.Phil

Ph.D Nisha Saini

Gurunanak Dev university,

Punjab,India

Priya Singh

BabashahebBhimraoAmbedkar

University(A Central university) Vikas Kumar

University of Delhi, Delhi

Deepika Singh

BabashahebBhimraoAmbedkar

University(A Central university)

Swati Aggrawal

University of Delhi, Delhi

Vijay Kumar Singh

BabashahebBhimraoAmbedkar

University(A Central university)

Pooja

University of Delhi, Delhi

Chandraprakash Gond

BabashahebBhimraoAmbedkar

University(A Central university)

Nidhi Chadha

Department of Chemistry,

University of Delhi, Delhi

Meenakshi Saklani

BabashahebBhimraoAmbedkar

University(A Central university)

Neelam Kumari

Department of Chemistry,

University of Delhi, Delhi

Soni Yadav

Institute of Engineering &

Technology, Lucknow

Simpi Mehta Amity School of Applied Sciences,

Amity University, Gurugram, Haryana

Pooja Srivastava

Department of Biotechnology

Delhi Technological University, N

Delhi

Post- Doctoral Dr AnupriyaAdhikari

BabashahebBhimraoAmbedkar

University(A Central university)

PG Students 17 (Completed) 6 (Ongoing)

Honors, Recognition and Awards

1. Commissioned visiting researcher/ Professor, Department of advanced nuclear sciences,

Quantum medical sciences directorate, National Institute of Radiological Sciences, Japan

from1 April 2018 to 31 March 2022, National Institute of Radiological Sciences, Japan

(International).

2. DST-ITS Travel Award, 2018 DST, India (International).

3. DBT-CTEP Travel Award, 2019, DBT, India (International).

4. ICMR International travel Award, 2019 ICMR. India (International).

13

5. JSPS Bridge Fellowship, 2019 Japan Society for the Promotion of Science (JSPS)

(International).

6. Nominated member of MEXT research Scholarship 2019 & 2020, Japan Information

Center Embassy of Japan(International).

7. IPR Award (grant) UPCST , 2020, UP CST (National).

8. Award for NIRS-IAEA-CC meeting 2014 (selected by IAEA as a candidate to represent

Asia-Euro region), 20th February, 2014 at Akihabara, Tokyo).

9. IAEA (United Nation) Fellow 2012 and 2013

Membership of Professional Bodies

The Japanese Society for Neurochemistry Member (C07452)

The Japan Neuroscience Society Member (2012156013)

Member (301120)

Society of Radiopharmaceutical Sciences (SRS) Full Member (Member ID: 1817)

American Chemical Society Member (MEMBERSHIP NUMBER: 32375697)

PLOS ONE Academic Editor

Indian Society of Nanomedicne Founder Life Member (ISNM-LF-088)

JSPS Alumni Association membership (JSPS-IJAA) Lifetime Member

The Indian Science Congress Association Life Membership (L32923)

Journal of Molecular Imaging & Therapy Editorial Board Member

Indian Society of Neurochemistry Member

Society of Nuclear Medicine, India Life Member (T-32)

Society of Nuclear Medicine and Molecular Imaging (SNMMI) Full Member (Member ID: 413214)

14

Seminar/Conference/Symposia /Workshops Organised

1. Convener- Summer Training school, TRASIC – to trace the Signature of Materials

Summer Training School on Instrumentation and Characterizations. May 24-25,2018 ,

BBAU, Lucknow, U.P., India

2. Organizing Secretary- Celebration of 87th birth anniversary of Bharat Ratna Dr. A.P.J.

Abdul. October 15-16, 2018. BBAU, Lucknow, U.P., India

3. Convener- Winter Training School, TRASIC – to trace the Signature of Materials

Summer Training School on Instrumentation and Characterizations. Jan 30-31,2019 ,

BBAU, Lucknow, U.P., India

4. Joint Organizing Secretary- Important Techniques for Characterization of Molecules,

Faculty of Chemical Sciences, Shri Ramswaroop Memorial University, March 25-29,

2019, Lucknow, U.P., India

5. Organizing Secretary- Organizing Secretary- Global Conference on the Control of Green

House Gases at the Source by Physical and Chemical

Technology,(GCCGHGSPCT2k19), 22-24 April, 2019, BBAU Lucknow-226 025

6. BBAU- DRDO ER-IPR (Directorate of Extramural Research & Intellectual Property)

Meet Organized by Dr. Anjani Kumar Tiwari,06 Feb, 2020, BBAU Lucknow

7. Convener- Workshop on Cheminformatics in drug discovery and research, 26-28 Feb,

2020, BBAU Lucknow

Countries Visited

(Japan )

IAEA Fellow, 2012

IAEA fellow, 2013

IAEA-NIRS CC meet 2014

JSPS Fellow (Invited) 2014-15

JSNM Conference at Okinawa Japan 2018

MEXT Fellow/Visiting Researcher, at NIRS, May 2019

From 28th Nov to 27th Dec 2019, JSPS Bridge Fellow at NIRS Chiba Japan

Country (Dubai) - 2018

Country (Thailand)

June 2019-The Faculty of Medicine, Siriraj Hospital, Mahidol University. Bangkoknoi, Bangkok, 10700

Country (Greece)

Oct 2019, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece (With

Prof. Ioannis Lykakis)

15

Invited Lectures/Talks/Chair/Co-Chair in Seminar/Conference/Symposia

/Workshops

International Conferences/seminars/meets/workshop/symposium

Title of

Conferences/semina

rs/meets/workshop

/symposium

International/

national

Title of paper

presented

Presented

(place and

date

Role

(coordinator/

participant/fa

culty/presente

r/author)

International

seminar on recent

trends in Life

Sciences and

Biotechnology,

International Role of PET/MRI for

understanding of

neuron-glial

interactions

12-14 Dec

2020,

University of

Delhi

Invited

Presenter

Summer School on

Organic and

Halogen

Radiochemistry

(CAFACHEM

2020) dedicated to

State-of-Art

Organic/Halogen

Radiochemistry

and its application

in PET tracer

development,

International Improved

Acetamidobenzoxazol

one derivatised

Radioligand for

Visualization of 18

kDa Translocator

Protein and their

comparison with

Luminescent

nanoprobe of TSPO

August 25-

28, 2020,

King’s

College

Waterloo

Campus,

London

Presenter

5th International

Medical Olympiad

at Thessaloniki

Greece. Oct 3 to 6

Oct 2019

International Evaluation of third

generation

translocator protein

selective PET

radiotracer (11C) to

access microglial

activation and

prospect beyond

TSPO

at

Thessaloniki

Greece. Oct5

2019

Invited

Presenter

13th Asia Oceania

Congress of

Nuclear Medicine

and Biology

International Third generation

TSPO ligand and their

applicability

Shanghai,

China May

9th to May

12th2019

Presenter

Global Conference

on the Control of

Green House Gases

at the Source by

International PET radiochemistry in

Green environment

22-24 April,

2019,

Department

of Chemistry

Presenter

16

Physical and

Chemical

Technology

(GCCGHGSPCT2k

19),

Babasaheb

Bhimrao

Ambedkar

University (A

Central

University),

Lucknow

58th Annual

Scientific Meeting

of the Japanese

Society of Nuclear

Medicine

International Modified

acetamidobenz-

-oxazolone derivatised

biomarkers for TSPO

quantification

15 to 17th Nov

2018

Oral Presenter

NANOBIOTECK International Panelist/Observer/

Invited Guest

At NANOBIOTECK

All India

Institute of

Medical

Sciences, New

Delhi from

24th - 27th

October 2018

Panelist/Invited

Guest

49th Annual

Conference of the

Association,

SNMICON2017

International Current paradigm of

the 18-kDa

translocator protein

(TSPO) third

generation ligands

developed by

acetamidobenzoxazol

one

15-17th Nov,

2017 at New

Delhi

Oral Presenter

47th Annual

Conference of the

Association,

SNMICON2015

International N4 vehicle based

Acetamidobenzoxazolon

e derivative for imaging

of Translocator Protein

(18 kDa) during

inflammatory condition

27th February,

2016 at

JIPMER,

Puducherry

Presenter

6th International

Symposium on

Current Trends in

Drug Discovery &

Research (CTDDR-

2016)

International Design, synthesis and in

vitro evaluation of

benzoxzolone based

agents for TSPO in

brain

25th to 28th Feb

2016 at CDRI

Lucknow

Presentor

IAEA Collaborating

Centre

Commemorative

Symposium

International NIRS-IAEA-CC

meeting (as a selected

representative from

Asian zones)

20th February,

2014

Akihabara,

Tokyo

Invited Speaker

54th Annual Meeting

of Japan Society of

Nuclear Medicine

International Acetamidobenzoxazolon

e-based ligands for

imaging of translocator

protein (18 kDa) during

neuro inflammatary

Osaka, Japan

(Session Title:

Brain :

Injury/Neuroin

flammation),6-

Oral

presentation

17

condition in the brain 8th Nov 2014

The 20th

International

Symposium on

Radiopharmaceutical

Sciences, 2013, Jiju,

South Korea, 12-17

May

Perception into Hypoxia

Selectivity and

Electronic features of

Symmetrically

Substituted

Bisthiosemicarbazone

ligands and their 64Cu

Complexes: A

computational approach

13th May Oral

presentation

2nd World Congress

on Ga-68

(Generators and

Novel

Radiopharmaceutical

s), Molecular

Imaging

(PET/CT), Targeted

Radionuclide

Therapy &

Dosimetry (SWC-

2013)

International Design of

radiopharmaceuticals

28th Feb-2nd

March, 2013 at

INMAS

Faculty

1st Indo-swiss

Workshop on Novel

Radioligands for

Neuro/Neuro-Onco

Imaging

International Labelling strategies

“Non-peptidic ligands

for brain imaging”

6th-7th Dec

2013, Delhi

Oral

Presentation

National Conferences/seminars/meets/workshop/symposium (2018

onwards…)

1- Expert Talk on "Neuroreceptor quantification a need of PET radio-chemistry in current

scenario,2018 Expert Talk on "Neuroreceptor quantification a need of PET radio-

chemistry in current scenario, Deptt. of Chemistry, Biochemistry & Forensic Sciences

Amity University , Gurugram.

2- Modern Trends in PET/SPECT imaging & Technologies, 25thAug 2018, National

Seminar on “Recent trends in Biomedical Technology, Aryakul college of

pharmaceutical college Lucknow.

3- Prospective third generation PET ligand for PBR/TSPO, 3 – 4 September,2018,

International Conference on Advancement in Science & Technology (ICAST- 2018),

ICAST-2018 Visva-Bharati Santiniketan.

4- Chemical Approaches in Positron emission tomography, 2nd-3rdNovember, 2018,

National Conference on Recent Approaches and Innovations in Chemical Sciences

[RAICS-2k18], Shri RamswaroopMemorial University (SRMU Lucknow.

5- Important Techniques for Characterization of Molecules, March 25th-29th, 2019

Workshop on “Important Techniques for Characterization of Molecules”, Faculty of

18

Chemical Sciences, Shri Ramswaroop Memorial University Babasaheb Bhimrao

Ambedkar University (A Central University), Lucknow Shri Ramswaroop Memorial

University, Lucknow

6- Expert and Panalist, 2019 10 th India-Japan S&T Seminar International Conference on

Emerging Advancement in Science and Technology (IC-EAST), Manekshaw

Auditorium, New Delhi.

7- Biomedical modalities in our health prospective, October 19th to 23rd, 2019, Advances in

Renewable and Bioenergy, Department of Chemical engineering IET Lucknow (Sitapur

Road) Lucknow.

8- Autoradiography a noninvasive tool to evaluate nanomaterial in preclinical studies, 19-23

August 2019, Nanomaterilas and Life, Division of Cyclotron and Radiopharmaceutical

Sciences Institute of Nuclear Medicine and Allied, Delhi.

9- Heavy metal removal by EDTA (His)2 from the soil, February 8-9, 2020, Conference of

The Indian Science Congress Association (Allahabad Chapter), Dr. Shakuntala Misra

National Rehabilitation University, Lucknow.

10- Bioinformatics and Biomedical Devices in New Era, 11th Feb 2020, Facets of Research in

Biology, Swami Srdhanand College, University of Delhi, University of Delhi.

11- Understanding of Brain through modern Biomedical modalities, 28 Jan to 1st Feb 2021, Faculty development program at Department of Applied Science and Humanities,

Rajkiya Engineering College, Kannauj, sponsored by AKTU, Lucknow

16

Administrative Responsibilities in the Institute/University:

At Institute of Nuclear Medicine & Allied Sciences, DRDO, Delhi

Institutional Project coordinator, Finance (2016 -18)

Member of Departmental Research Committee (DRDO/Universities).

Member academic council for DRM/DNB courses

Member of DRDO five-year project formulation committee

Member Technical evaluation committee (2013 -17)

Member Technical specification committee (2012-2014)

INMAS, DRDO Sports Officer (2011-13)

Editorial board member for Hindi magazine Prastuti (2005-2013)

Editor in Chief for INMAS news bulletin “Nucleus” (2016 -18)

At Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow

Assistant Director, University, Science Instrumentation Center (USIC), Babasaheb Bhimrao Ambedkar University, Lucknow since Feb, 2018-Till date.

Member in School Board (School of Physical & Decision Sciences), Babasaheb Bhimrao

Ambedkar University, Lucknow. During 2019 to till date Member, Anti Ragging Cell, Babasaheb Bhimrao Ambedkar University, Lucknow since 2019 to

till date. Member Secretory, University Patent Cell, Babasaheb Bhimrao Ambedkar University,

Lucknow since 2019 to till date. Deputy Dean, Students Welfare (Men), Babasaheb Bhimrao Ambedkar University, Lucknow

since 2019 to till date.

19

Additional Information (If Any)

Research OutcomeTotal Peer Reviewed Publication – 80 (75 International +5 national)

Publication wise distributionAmerican chemical society -4

Royal Society of Chemistry- 20

Wiley Interscience- 19

Science Direct - 10

Springer-5

Taylor & Francis- 4

Mary Ann Liebert, Inc- 9

Others- 9

Source-scopus

COMPREHENSIVE KINETIC AND MECHANISTIC STUDIES OF SOME LIGEND SUBSTITUTION AND OXIDATION REACTION ON FE(III),FE(II) AND CO(II) METAL CENTRES AND THEIR

APPLICATIONS IN TRACE DETERMINATION OF TOXIC METALS Objectives: 1-The kinetic and mechanistic studies of Hg (II) catalyzed exchange of coordinated cyanide in hexacyanoferrate (II) by various ligands at specific wavelength of the corresponding to metal ligand charge transfer (MLCT) transitions 2- Ligand exchange reactions of low spin ligand of transitional metal complexes with pyrazine and its complexes 3- Kinetic determination of mercury (ii) at trace level from its catalytic effect on ligand substitution reactions 4- Kinetic and analytical study of ligand substitution reaction of N-(2-hydroxy ethyl) iminodiacetatoiron (III) complex, [Fe HIDA(OH)] 4-(2-pyridylazo) resorcinol (Par) 5- Mechanism of the interaction of periodate ion with polyaminocarboxylate(L) coobalt (ii) complexs (where L = EDDT, HEDTA, NTA, DTPA, PDTA and HPDTA) in aqueous medium

Further Applications:- Environmental Sciences: Analytical Methods & Applications for Environmental Analysis. Food Chemistry: Nutritional and Clinical Methods for determination of toxicants. Microbial Degradation of Organic Pollutants (Application in Biotechnology).

[18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain

Theme

Approach

Objective

Evaluation of our PET ligand derivatised from novel skeleton of acetamidobenzoxazolone for assessment of 18 kDa translocator protein (TSPO) in ischemic rat and human postmortem temporal cortex brain sections (from Center for Neurodegenerative Disease Research at the University of Pennsylvania, USA) to determine the putative sensitivity of the ligand for the TSPO polymorphism rs6971

Insights & Results

Insight from this publication TSPO rs6971 polymorphism did not affect binding sites for [18F]FEBMP

[18F]FEBMP is a promising new tool for visualization of neuroinflammation

This ligand may beneficial for detecting activated microglia in inflamed human brain as seen in the present ischemic

rat model

Future Prospects

Advanced methods like cluster analysis will be performed with dynamic PET studies of individual to

determine appropriate reference region for quantification of TSPO.

Block Copolymer Based Nanoparticles for Theranostic Intervention of Cervical Cancer: Synthesis, Pharmacokinetics, and in Vitro/in Vivo Evaluation in HeLa Xenograft Models

Theme

Approach

Objective

Key Questions Nanotheranostic systems for imaging and therapy of cancer

1- Are these theranostic nanoparticles are effective delivery vehicles for tumor−specific delivery

2- Can such anticancer therapeutics aimed at FR(+ve) tumors may show added feature of simultaneous diagnosis

Results

Two NPs, called M-GEG and M-EGFA NPs, have been used to target cervical carcinoma passively and actively (The first NP consists of a triblock copolymer PEG-b-poly(glutamic acid)-b-PEG (GEG). The second NP consists of a diblock copolymer PEG-b-poly(glutamic acid) (EG) conjugated with folic acid for active targeting to form EGFA. Methotrexate (MTX) has been encapsulated in each formulation)

Future Prospects

Important for future for fabrication of stimuli-responsive di/tri block copolymers, for specific targeting/ precise

control of the drug-release and versatility in human clinical setup

Computational prediction of interaction and pharmacokinetics profile study for polyamino-polycarboxylic ligands on binding with human serum albumin

Theme

Approach

Objective

Computational Work flow & Results

Future

Prospects

1- Sensing and quantification of neurotransmitters by combining responsive MR contrast agents and

fluorescence probes

2- Supramolecular chemistry approaches to design and develop artificial hosts when approaching for

neurotransmitter-sensitive MR agents.

Visualization of neurotransmission in deep living may get great insight for understanding the brain function.

Demonstration of the global impact of my publications with citation map

(Publons dashboard)

Universit´e de Bordeaux, France

University of Oxford

National Institutes

for Quantum and

Radiological

Science, Japan

Universidad Nacional

Autonoma de Mexico

Nanjing Medical University

My International Research Network

Zhejiang University

School of Medicine

Royal Prince Alfred Hospital

NSW , University of Sydney, Australia

Mahidol UniversityThailand

Aristotal university greece

Seoul National University, Korea

Potentiometric titrator

Computational (CADD) Lab

Dr. Anjani with team

Physico- chemical laboratory

Current Research

Dec 2019,

Meeting with the members of International

Policy Planning Division, Headquarters for

International Affairs

Japan Society for the Promotion of Science

(JSPS), Japan

3-6 Oct 2019,

5th International Medical Olympiad

at Thessaloniki Greece

15 to 17th Nov 2018 ,

58th Annual Scientific Meeting of the Japanese

Society of Nuclear Medicine

Okinawa, Japan

2015, International Atomic Energy Agency (IAEA) meet,

Japan

May 2019, Department of Nuclear MedicineOsaka university, Japan

2019, Division of Nuclear Medicine

Faculty of Medicine Siriraj Hospital

Mahidol University, Thailand

2019Institute of Nuclear Medicine & Allied

Sciences (INMAS) - DRDO

2018

2018

RAICS-2k18