Natalio Cruz - Fragmentación ADN - II Simposio Reproducción Asistida Quirón

7/22/2019 Natalio Cruz - Fragmentacin ADN - II Simposio Reproduccin Asistida Quirn

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Mibohd ob

Fri`mobtiakb Oeovini noe INB.

www.ibnrdmonk.adm

baruzJ`mx.os

ADDSNKBINDS BIAKDBIE IBNSDED@KI

Nr. Bitiekd Aruz


2/97

Giceir no Mibohd no ei Fri`mobtiakb, os giceir noe8

Zipoe noe _red`d d Ibnred`d ob Soprdnuaakb

Adbaoptds8

Ei ori no ei KAQK y ei Fri`mobtiakdb noe NBI.

Oe aimckd no dchotkvd noe Ibnred`d8

Ibnred`d noe ospormitdzdkno


3/97

Buovd Zirink`mi

Mohdri noe Virb Nksfubakdbos soxuieos y oyiaueitdrkis

Ietoriakdbos ibitmkais8 pobo, moitd, ota.

Mohdri noe Qomob8 Adbaobtriakb8 Izddspormki, Dek`d., Zdek., ...

Aieknin8 Istobd., Board., ^oritd, ...

Zeismi somkbie8 Vdeumob, pG,...

Mohdri noe @imotd8

Ardmdsmkais Mdeoaueiros

@obtkais

Fri`mobtiakb noe NBI


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ofoatd kaocor` 8

Qk ckob oe 30% no eds ospormitdzdknos tkobobfri`mobtind ob miydr d mobds `rind su NBI

(NID ZSKMISKD),Oe 01% rostibto tkobob ub tkpd no nid(NID QOA_BNISKD) ("nid dauetd") yquo os kbadmpitkceo adb oe nosirrdeed noub omcirizd i trmkbd


9/97

AMD MIBOHIS OE I_MOB^D NO FSI@MOB^IAKDB4

(Zipoe noe _red`d d Ibnred`d ob Soprdnuaakb)

- Adbdaor oe prdceomi

- Nki`bdstkair y tritir ei aiusi

- ^ritir oe sbtdmi


10/97

Adbdaor oe Zrdceomi8


11/97

Yuo os Fri`mobtiakb noe NBI4

- Ob eds ospormitdzdknos oe INB bk so tribsarkco, bk so trinuao iISB, pdr ed quo i nkforobaki no dtris aeueis bd puono roiekzirubi rospuosti admpeoti no ipdptdsks quo eeovo i ei muortoaoeueir ob aisd no quo ei aeuei rosueto niini.

- - Soiekzib ubi fdrmi rostrkb`kni no ipdptdsks, quo adbnuao ei

fri`mobtiakb noe INB.(Qillis ot ie., 3::>).


12/97


- Ob ubi aeuei sdmtkai ei ostkmueiakb noei vi ipdpttkai kbtrbsoai adbnuao i eiipirkakb ropobtkbi no obndbuaeoisis quosdb ekcorinis no ei mktdadbnrki (admdobndbuaeoisi @) d iatkvinis ob oe aktdsde(nosdxkrrkcdbuaeoisi aispisi-iatkvind) y

euo`d so muovob ob oe baeod piri rdmporoe INB nobtrd noe buaeodsdmi.

-Ob eds ospormitdzdknos ei sopiriakb fskai no eismktdadbnrkis y oe ospiakd aktdpeismtkad drk`kbi quomoaibksmds no ei aeuei sdmtkai bd puonob sor dporitkvds.

- Ob oeeds eis ospoakos roiatkvis noe dx`obd (SDQ) (Ldppors otie., 3::7), iatkvib ei ruti ipdpttkai kbtrbsoai, airiatorkzinipdr ei fdrmiakb no SDQ mktdadbnrkie, quo prdnuao ub niddxknitkvd ob eis cisos noe NBI, y ostd eeovi i rdturis ob eisainobi noe NBI (Iktlob y No Kuekks, 3::;).


13/97


-Qdb aipiaos no prdnuakr ei iatkviakb no eis aispisis y no

oxtorkdrkzir ei fdsfitknkesorkbi (Pob` ot ie., 3::3).

-Ie oxprosir miraindros no ipdptdsks ob su suporfkako, ostdsospormitdzdknos niinds puonob sor knobtkfkainds yfi`daktinds ob su pisd pdr oe triatd `obktie fomobkbd< no mdnd

quo sorb oekmkbinds y skb quo so isdako adb ubi rospuostikbfeimitdrki ob tdni ro`ei (Lurdsili ot ie., 3::1)


14/97

Oe Nid noe NBI spz puono tobor tros pdtobakieos moaibksmds8

9. _bi Adbnobsiakb nofoatudsi no ei ardmitkbi nuribto ei ospormitdòbosks

3. EiIpdptdsksnuribto ei ospormitdòbosks d ob oe triatd òbktie

1. Oe Ostrs Dxknitkvd pdr SDQ prdnuaknis8

- Kbtorbimobto

- Oxtorbimobto

Cial`rdubn8


15/97

Amd so prdnuao Fri`mobtiakb noe NBI4

Aiusis

^ostkaueiros

mokdsks no ei prdfiso K

Ospormkd`bosks

Zdst-tostkaueiros

ostrs dxknitkvd ob opknnkmd

iatkviakdb no aispisis ospormtkais
http://www.stallionsdirect.com/services/collection/images/freezer.jpghttp://www.usc.edu/hsc/dental/ghisto/rep/c_83.html


16/97

Zdtobakieos moaibksmds btkmds8

9. Ietoriakdbos nuribto oe prdaosd no ei ospormkd`bosks8 Buaeoisisobn`obis quo adrtib y ek`ib oe INB nuribto su prdtimkbiakb.

Kbnuaakb kbadbtrdeini no ipdptdsks

3. Nuribto ei mk`riakb no ospormitdzdknos minurds o kbminurdsnosno edstcueds somkbfords ie opknnkmd8 Kbminurds adb oxaosd no aktdpeismi Iumobtd no obndbuaeoisis icorribtos

1. Iatkviakb no aispisis y obndbuaeoisis ob ospormitdzdknos nkforobakindspdr fiatdros fskad-qumkads8 kbfoaakdbos, kbfeimiakb, virkadaoeo, ota.

Cial`rdubn8


17/97

Qo gib notoatind ietds bkvoeos no SDQob oe somob no ub 3?% no edsgdmcros kbfrtkeos

Eds bkvoeos no SDQ gib sknd isdakinds adb oe nid no INB no ospormi,iubquo bd so sico oe umcrie pdr obakmi noe auie giy nid noe INB.

Eds SDQ ob somob so `oborib pdr ospormitdzdknos(ospoakiemobto,nofoatudsds d kbminurds) y eouadaktds.

Ei ekcoriakb adbtrdeini no cihds bkvoeos no SDQ os bdrmie, y boaosirki piriei fubakb no eds ospormitdzdknos bdrmieos

Zord eds bkvoeos ietds no SDQ puonob aiusir nksfubakb ospormtkai

Ei susaoptkckekninno eds ospormitdzdknos gumibds i ostrs dxknitkvd sonoco prkbakpiemobto i ei icubnibaki no aknds `risds kbsiturinds ob eimomcribi peismtkai noe ospormitdzdkno.

Sosumob8


18/97

Ostds aknds `risds kbsiturinds prdpdrakdbib feuknozquo os boaosirki piri8 eds ovobtds no fuskb no momcribi (pdr ohomped, roiaakb noe iardsdmi

o kbtoriaakb ospormitdzdkno-vued) y Ei mdvkeknin no eds ospormitdzdknos

Qkb omcir`d, ei biturieozi kbsiturini no ostds aknds eds pronkspdbo ie itiquono eds rinkaieos ekcros y pordxkniakb ekpnkai no ei momcribi peismtkai noeospormitdzdkno.

_bi voz quo osto prdaosd so gi kbkakind, so prdnuao8 Iaumueiakb no porxkndsno epknds ob ei suporfkako no eds

ospormitdzdknos y norkvir ob ub nid dxknitkvd ie INB

Qo gi nomdstrind quo eis fuobtos no SDQ puonob sor oxòbisd obnòbis

Imcis gib sknd aipiaos no kbnuakr nid no INB no ospormi kb vktrd,adbfkrmibnd quo eis SDQ puono nosompoir ub pipoe ob ei otkdedì no nidno INB no ospormi ob gdmcros kbfrtkeos

Sosumob8


19/97

SOQ_MOB. 3/>8 SDQ. Ciso noe prdceomi

IB^KDWKNIB^OQ !!!


20/97

Oe equknd somkbie os ubi kmpdrtibto fuobto no ibtkdxknibtos (ronuatdros noSDQ) y os aeivo ob ei prdtoaakb noe nid dxknitkvd no eds ospormitdzdknos

Ostd os pirtkaueirmobto kmpdrtibto pdrquo8 Eds ospormitdzdknos tkobob pdad aktdpeismi (eis obzkmis ibtkdxknibtos

sdb òboriemobto kbtriaoeueiros), Zratkaimobto bd giy aipiaknin piri ei sbtosks no prdtobis y Giy pdai aipiaknin ibtkdxknibto

Qdb obzkmis obnòbis ronuatdris no SDQ Ei suporxknd nksmutisi (QDN), aitieisi y èutitkb pordxknisi (@ZW). Ostis obzkmis ibtkdxknibtos so obauobtrib ob oe triatd roprdnuatkvd

misauekbd y ob oe somob Inoms, virkds ibtkdxknibtos bd obzkmtkads (vktimkbis A y O, gkpdtiurkbi,

tiurkbi, E-airbktkbi, ekadpobd) timckb so obauobtrib ob oe somoby roprosobtib`rib pirto no ei iatkvknin ibtkdxknibto tdtie somkbie

Sosumob8


21/97


22/97

AI_QIQ no Fri`mobtiakb noe NBI

Onin

Iumobtd no ei tomporituriob eds tostaueds.

Virkadaoeo

Fkocro, omporituri imckobto

Zrdfoskdbos d Gcktds

Zrdceomis kbgorobtos i ei ospormitdòbosks/ospormkdòbosks.

Iusobaki no prdtimkbis Oeoviakb no SDQ

Gkpd`dbinksmds

Iumobtd no eis aeueis kbfeimitdrkis8

Kbfoaakdbos d kbfeimiakdbos òbktieos y prdsttkais

Iòbtos txkadsnkroatds

Yukmkd-, Sinkdtoripki, Yumkads, iciad, ota. Adbòeiakbno somob.
http://www.stallionsdirect.com/services/collection/images/freezer.jpghttp://www.usc.edu/hsc/dental/ghisto/rep/c_83.html


23/97

Virkadaoeo8

IN_E^DQ BDSMDXDDQZOSMKADQ8

IN_E^DQ OQÔSKEOQ8

Giy nksmkbuakb no roauobtd y mdvkeknin Giy ifoatiakb no ei mdrfdedì48 Giy ub iumobtd no `dtis aktdpesmkais (mdrfdedì isdakini i ostrs

dxknitkvd), quo ostb roeiakdbinis adb nids ob oe NBI. INDEOQAOBÔQ8 adb virkadaoeo poso i bd gicor nkforobakis ob eds

pirmotrds somkbieos sk so vo ub kbaromobtd ob oe NFK (ADMO^)

QO NOCOB DZOSIS48 Ob piakobtos dporinds so dcsorvi mohdri.

Fortke Qtorke. 3::6 Mir


24/97

Iumobtds no ^omporituri8

Fkocro8 puono ietorir oe ritkd gkstdbi 8 prdtimkbi. [ soisdaki i ibdrmiekninos ostruaturieos. Ostd puono sornocknd i nofoatds ob ei ospormitd`bosks (porkdnd oboe auie daurro ei nopdskakb no eis prdtimkbis)

^omporituri imckobto Gcktds isdakinds i ietis tomporituris osardtieos

(siubis, mibtis aiekobtos, ota), Notormkbinis prdfoskdbos(adakbord, pibinord,

i`rkauetdr, pkbtdr, sdenindr, ota) iumobtib oe nid.


25/97

Kbfeimiakb, Kbfoaakdbos8

Kbfeimiakb noe triatd `obktie8 kbfeimiakb noe opknnkmd,tostaued d prstiti prdvdai eouadaktdspormki, kbaromobtd noospoakos roiatkvis y pdr tibtd fri`mobtiakb noe NBI.

Kbfoaakdbos8 Eis muostris adb eouadaktds Oe nid puono sor aiusind pdr ei ipdptdsks( muorto

aoeueir adbtrdeini). Ei ipdptdsks nostruyo iprdxkminimobto oe 0?% no eds spz. Ei ipdptdsks soeoatkvi ovkti ei fdrmiakb no spz ibdrmieos.

Qillis ot ie. su`korob quo spz adb NBI niind gib osaipind noosi ipdptdsks adbtrdeini, yi soi pdr onin no eds piakobtos,`dbindtdxkbis d toripkis (abaor, ota.).


26/97

^DWKADQY_O AI_QIB FSI@MOB^IAKDB NOE NBI8


27/97

Onin8


28/97

AI_QIQ NO FSI@MOB^IAKDB NOE NBI8

Adbdaknis Nosadbdaknis

9. ^xkais

3. Kbfeimitdrkis1. Kbfoaakdsis>. Fskais?. Virkadaoeo

^riticeos Auriceos4 Kbtriticeos


29/97

AMD MIBOHIS OE I_MOB^D NO FSI@MOB^IAKDB4

(Zipoe noe _red`d d Ibnred`d ob Soprdnuaakb)

- Adbdaor oe prdceomi

- Nki`bdstkair y tritir ei aiusi

- ^ritir oe sbtdmi


30/97

Ekfostyeo.

Adubsoekb` ibn Onuaitkdb

Sksl FiatdrsAiusos

Ompkrkaie

troitmobts

I^S

Zktfiees td ivdkn

Mibi`omobt df NBI FSI@MOB^I^KDB


31/97

3.- Ekfostyeo Mdnkfkaitkdb Qtdp smdlkb`

Ekmkt dr ivdkn ieadgde

Fdeedw goietgy nkot

Oxorakso roùeirey

Mibiòmobt df NBI FSI@MOBÎ^KDB


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Ekfostyeo.


Sksl FiatdrsAiusos

Ompkrkaie

troitmobts

I^S

Zktfiees td ivdkn

Mibi`omobt df Mieo Kbfortkekty

OQGSO


42/97

^SI^IMKOB^D8 SOADMOBNIAKDBOQ OQGSO

(Bdbstordknie ibtk-kbfeimmitdry nru`s)


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NKAEDFOBIAD


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Ostind prd-kbfeimitdrkd


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IB^KDWKNIB^OQ


49/97

H Isskst Soprdn @obot. 3::; Iu`30-13. ndk8 9:.9::0/s9:79?-::;-;1>1-?. Opuc 3::; Qop 9;.

Ibtkdxknibts ibn sporm NBI nimiò8 i aekbkaie porspoatkvo.Xkbk I, Qib @icrkoe M, Ciizoom I.QduraoNkvkskdb df _rded`y, Nopirtmobt df Quròry, Sdyie Vkatdrki Gdspktie, Ma@kee _bkvorskty, Mdbtroie, YA,Aibini. zkbkirmibnJyigdd.adm

Eds nitds su`korob quo eds supeomobtds ibtkdxknibtos no ei nkoti puonobtobor ub ofoatd cobofkakdsd, ronuakobnd ei Fri`mobtiakb noe NBIospormtkad, ob gdmcros adb oeovind bkvoe no fri`mobtiakb noe NBI.

Oe moaibksmd btkmd bd gi sknd ckob osticeoaknd

Ei miydri no eds ostunkds sdb MOBDSOQ y skb crizd peiaocd

Ieùbds ostunkds peibtoinds gib mdstrind rosuetinds adbtrinkatdrkds.
http://www.ncbi.nlm.nih.gov/pubmed?term=Zini%20A[Author]&cauthor=true&cauthor_uid=19768529http://www.ncbi.nlm.nih.gov/pubmed?term=San%20Gabriel%20M[Author]&cauthor=true&cauthor_uid=19768529http://www.ncbi.nlm.nih.gov/pubmed?term=Baazeem%20A[Author]&cauthor=true&cauthor_uid=19768529http://www.ncbi.nlm.nih.gov/pubmed?term=Baazeem%20A[Author]&cauthor=true&cauthor_uid=19768529http://www.ncbi.nlm.nih.gov/pubmed?term=Baazeem%20A[Author]&cauthor=true&cauthor_uid=19768529http://www.ncbi.nlm.nih.gov/pubmed?term=San%20Gabriel%20M[Author]&cauthor=true&cauthor_uid=19768529http://www.ncbi.nlm.nih.gov/pubmed?term=Zini%20A[Author]&cauthor=true&cauthor_uid=19768529


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Ietgdu`g kb vktrd stunkos givo nomdbstriton i cobofkakie offoat df ibtkdxknibt

suppeomobts kb prdtoatkb` sporm NBI frdm oxd`obdus dxknibts, .


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tgo offoat df tgoso ibtkdxknibts kb prdtoatkb` sporm frdm obnd`obdus SDQ,`obteo sporm prdaosskb` ibn arydprosorvitkdb gis bdt coob osticeksgon.

Ibtkd knibts


53/97

Ibtkdxknibts

Qgdwoee M@ ot ie. ^go Adagribo Ekcriry 3:99, Kssuo 9


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I tk kn t


56/97

^ritimkobtd adb 9 ` no vktimkbi A y 9 ` no vktimkbi Onkirkd nuribto 3 mosos. Ob 06% no eds aisds so eeoì i ubi nksmkbuakb no NFK. Bd so vob nkforobakis ob eis tisis no fortkekziakb d no

nkvkskb, pord eis tisis no omcirizd pisib noe 6,; ie

>7,3 y eis no kmpeibtiakbno 3,3 ie 9;,6. Oe `rupd adb peiaocd bd mdstr nkforobakis ob oe NFK.

Gum Soprdn. 3::? Qop. Opuc 3::? Hub 3.KAQK kb aisos df sporm NBI nimiò8 cobofkakie offoat df drie ibtkdxknibt troitmobt.@road O, Sdmibd Q, Kiadcoeek M, Forrord Q, Cirdbk O, Mkbisk M@, _cienk F, Skobzk E, ôsirkl H.

H Ibnrde. 3::? Miy-Hub;-?1.Sonuatkdb df tgo kbaknobao df sporm NBI fri`mobtitkdb cy drie ibtkdxknibt troitmobt.@road O, Kiadcoeek M, Skobzk E, _cienk F, Forrord Q, ôsirkl H.

Ibtkdxknibtos8

I tk kn t
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Romano%20S%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Iacobelli%20M%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ferrero%20S%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Baroni%20E%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Minasi%20MG%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ubaldi%20F%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Rienzi%20L%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tesarik%20J%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Iacobelli%20M%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Rienzi%20L%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ubaldi%20F%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ferrero%20S%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tesarik%20J%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tesarik%20J%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ferrero%20S%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ubaldi%20F%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Rienzi%20L%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Iacobelli%20M%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tesarik%20J%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Rienzi%20L%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ubaldi%20F%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Minasi%20MG%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Baroni%20E%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ferrero%20S%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Iacobelli%20M%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Romano%20S%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus


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Ibtkdxknibtos8

^ritimkobtd adbMobovkt 9 admprkmknd ieni x 1 mosos provkds skb soeoaakb pdr NFKni tisis noe 17,?% ob piakobtos adbtritimkobtd frobto i 96% ob piakobtos adbpeiaocd. Bd so dcsorvib nkforobakis ob eitisi no fortkekziakb d aieknin omcrkdbirki

Iust B X H Dcstot @ybioade. 3::0 Hub0(1)8396-39.I ribndmkson adbtrde trkie oximkbkb` tgo offoat df ib ibtkdxknibt (Mobovkt) db pro`bibaydutadmo nurkb` KVF-KAQK troitmobt.^romoeeob L, Mkirk @, Frdkeibn N, ^gdmpsdb H.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Miari%20G%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Froiland%20D%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Thompson%20J%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Thompson%20J%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Froiland%20D%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Miari%20G%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus


58/97

IAKNDNOADQIGOIOBDKAD

(NGI)


59/97

Ei admpdskakb no epknds no momcribi so utkekzi admd kbnkaindr no ei feuknozno momcribi, no mdnd quo, auibtd miydr os oe adbtobknd ob I@ZK-AE (Iaknds`risds pdek-kbsiturinds no ainobi eir`i) ob ei momcribi ospormtkai, miydros su feuknoz, mohdr su mdvkeknin y so ospori ubi miydr tdeoribaki i eiarkdprosorviakb. (Mkeeor 3::>)

Oe aknd ndadsigoxiobdkad(A3386, NGI) os ub aknd `risd osobakiepdekkbsiturind (pdsoo 6 ndceos obeiaos) no ei sorko dmo`i-1.

Ostunkds provkds roiekzinds ob ibkmieos kbnkaib quo so puono mdnkfkair nofdrmi sk`bkfkaitkvi ei adbaobtriakb no NGI ob ei momcribi no edsospormitdzdknos mdnkfkaibnd ei adbaobtriakb no osto aknd `risd ob ei nkoti.(Xibkcdbk 3::6, Aordeekbk 3::6)

Inoms, osto iumobtd no NGI so trinuao ob ubi mohdri ob ei mdtkeknin noesomob arkdprosorvind (Crkbsld 3::?)


60/97

Iniptickeknin no ei momcribi ie nidprdnuaknd pdr oe prdaosd noadb`oeiakb/nosadb`oeiakb orimirainimobto suporkdr piri eds

ospormitdzdknos adb ubi oeovini feuknoz nomomcribi. (@kriun 3:::)


61/97

b=31

Nkforobtos ostunkds gib roeiakdbind ei admpdskakb ob I@ZK-AE, obospoakie NGI, ob gdmcros istobdzddsprmkads y bdrmdzddsprmkadsadb ei mdtkeknin ospormtkai

(^ivkeibk 3::6)

(Xieiti 9;;7)


62/97

Ibeksks admpdskakb I@ ob ospormitdzdknos no kbnkvknuds bdrmdzddsprmkads,istobdzddsprmkads, dek`dzddsprmkads y istobd-dek`dzddsprmkads8

Ospormitdzdknos no Kbnkvknuds bdrmdzddsprmkads 2 adbtobknd ob NGI

Miydr adbtobknd no I@Q y II ob kbnkvknuds istobdzddsprmkads,dek`dzddsprmkads y istobddek`dzddsprmkads y 5 bkvoeos no NGI (p5:.:9)

Soeiakb sk`bkfkaitkvi obtro adbtobknd ob NGI y mdtkeknin, adbaobtriakb y

fdrmis bdrmieos

(Ilsdy 3::6)


63/97

Ob gdmcros istobdzddsprmkads, i trivs no ei supeomobtiakbnkottkai adb >::-7:: m` ie ni no NGI nuribto 1 mosos so ginomdstrind iumobtir ei adbaobtriakb no NGI ob oe peismi somkbie ymdnkfkair ei admpdskakb ekpnkai no ei momcribi ospormtkai

(Adbquor 3:::).


64/97

_tkeknin noe aknd ndadsigoxiobdkad ob oe

tritimkobtd no ei kbfortkeknin misauekbiHuib @. eviroz Vde. 9:, B. 9, 3:93 , p`s. 917-9>3

>: piakobtos adb ub iumobtd ob oe bnkaono fri`mobtiakb noe INB ospormtkad

(NFK), monknd monkibto oe tost ^_BOE.

Qo kbaeuy i 3: piakobtos ob oe `rupdoxporkmobtie tritind adb 3:: m` no NGInorkvind no ei mkardie`i Qagkzdagytrkumsp. (@ostiNgi) aini 93 gdris

Nksmkbuyo no fdrmi sk`bkfkaitkvi oe NFK ipirtkr no ei prkmori somibi no tritimkobtd.


65/97

Dmoì-1 fitty iakns goep NBI fri`mobtitkdb kb sporm

Ibbuie Moot kb` d f tgo Im orkaib Qda koty fdr Soprdnuat kvo Monka kbo.

Dmoì-1 fitty iakns iro cobofkakie kb kmprdvkb` NBI fri`mobtitkdb kb sporm.

>6 virdbos ribndmkzinds i 9:?: m` df NGI d peiaocd.

NBI fri`mobtiakb (^_BOE) nosaobnk prd`roskvimobto no 36% i ;%.

Osti ndsks no NGI os oqukvieobto 1,::: m` no dmoì-1.

Soadmobnirdb ndsks no ?::-9,::: m` ie ni.

Aroob eds iutdros quo sk so ndcei ei ndsks puono mohdrir ib ms eifri`mobtiakb.

ZDQKCEOQ ADBAE_QKDBOQ


66/97

NGI sorvkri admd ibtkdxknibto obn`obd, admd prdtoaakb no mocribi.

Oe rostd no eds ibtkdxknibtossorib admd ibtkdxknibtos ox`obds

Fieti pdr notormkbir admpdbobtos

Giy quo sor soeoatkvd.



67/97

Ekfostyeo.


Sksl FiatdrsAiusos

Ompkrkaie

troitmobts

I^S

Zktfiees td ivdkn



68/97

Mibi`omobt df NBI

Fri`mobtitkdb

9.- Zktfiees td ivdkn kb tgo Eic

3.- Qoeoatkdb df Qporm fdr KAQK

1.- ^ostkaueir Ckdpsy


69/97

Froquobt ohiaueitkdb (ovory 3> gdurs dr eoss)

vs

Kbfroquobt ohiaueitkdbs (`roitor tgib 3> gdurs)

9.- Zorkdn df icstkbobao fdr IS^


70/97

VdeumoAdbaobtritkdbMdtkekty

NBI fri`mobtitkdb kbnox (NFK) (QAN Giedspormlkt)

Qomkbie pirimotors8

; 93:

Zro- ibn pdst-froquobt ohiaueitkdb


71/97

:

9

3

1

>

?

6

0

7

;

VDE.me

VDE. IBÔQ

VDE. NOQZ_OQ

:

3:

>:

6:

7:

9::

93:

mkee/me

A. IBÔQ

A. NOQZ_OQ

sporm adbaobtritkdbsomkbie vdeumos

:

9:

3:

1:

>:

?:

6:

0:

7:

%i

+c

i+c IBÔQ

i+c NOQZ_OQ

sporm mdtkekty

:

9:

3:

1:

>:

?:

NFK NFK IBÔQ

NFK NOQZ_OQ

NFK


72/97

3-? NiyZorkdn NikeyOhiaueitkdb

Vdeumo

NFK

Adbaobtritkdb = =

Mdtkekty = =

ADBAE_QKDB


73/97

Pgit porkdn df icstkbobao crkb`s icdut dptkmie somobquiekty4

Qimpeos dctikbon iftor nikey ohiaueitkdbs (wgobovorpdsskceo)

^go sgdrtost pdsskceo porkdn df icstkbobao

ADBAE_QKDB

9.- Zorkdn df icstkbobao fdr IS^

3 - ^kmo kb eic frdm ohiaueitkdb td mkardkbhoatkdb


74/97

^ris oe oyiaueind, oe bnkao no fri`mobtiakb noeNBI somkbie (NFK) bd pormiboao adbstibto ob oetkompd.

Fiatdros kbtorbds y oxtorbds (pG, tomporituri,

mibkpueiakb ob oe eicdritdrkd, ota.) ed vibiumobtibnd, i voaos adbsknoriceomobto

3.- ^kmo kb eic frdm ohiaueitkdb td mkardkbhoatkdb


75/97

Ei voedaknin i ei quo so fri`mobti oe INB

ospormtkad os airiatorstkai y nkforobto ob ainiospoako y, nobtrd no oeei, ob aini kbnkvknud< y soadbdao admd NKBIMKAI NO EI FSI@MOB^IAKDB



76/97

3. ^kmo kb eic frdm ohiaueitkdb td mkardkbhoatkdb

Qporm NBI fri`mobtitkdbmust co ubnorstddn is i nybimka

prdaoss8- ^gks ks bdt tgo simo iardss pitkobts ibn tkmo.

- Fri`mobtitkdb spoon kbfeuobaos pro`bibay rito.

1: mkbutos

;: mkbutos

> gdurs

3> gdurs

Qporm NFKs woro admpiron iftorohiaueitkdb it tgo fdeedwkb` tkmos8



77/97

Dptkmie ^kmo oeipson cotwoob ohiaueitkdb ibnmkardkbhoatkdb8

_p td ;: mkbutos (ipprdx.) cofdro mkardkbhoatkdb

Bovor `roitor tgib > gdurs

3. ^kmo kb eic frdm ohiaueitkdb td mkardkbhoatkdb

1.- Qomkbie tomporituro kb tgo eic


78/97

p

Kf sporm kb tgo eicdritdry ks lopt kb tgo kbaucitdr, tgoprdaossos df fri`mobtitkdb ibn viaudeo fdrmitkdb iroiaaoeoriton.

Offoat df tgo kbaucitkdbtomporituro db tgo

ippoiribao df viaudeitonspormitdzdi

(Cirtddv, adb`rosd Pirm 3::6)

Zktfiees td ivdkn kb tgo eic fdr IS 8


79/97

3.- ^kmo kb eic frdm ohiaueitkdb td mkardkbhoatkdb_p td ;: mkbutos (ipprdx.) cofdro mkardkbhoatkdb

1.- Qomkbie tomporituro kb tgo eic

33-3? A

Qimpeos dctikbon iftor nikey ohiaueitkdbs (wgobovor pdsskceo)9.- Zorkdn df icstkbobao fdr IS^

Zktfiees td ivdkn kb tgo eic fdr IS 8

Qoeoatkdb df sporm kb tgo eicdritdry


80/97

7:

Qoeoatkdb df sporm kb tgo eicdritdry

Mdrpgded`y gk`g mi`bkfkaitkdb

Ipdptdtka mirlors

Gyieurdbka iakn ckbnkb` (ZKAQK, Qporm Qedw)


81/97

Ospormitdzdknos ^ostkaueiros8

Ospormitdzdknos ^ostkaueiros8


82/97

p


83/97


84/97

Bds peibtoimds admprdcir sk dctobnrimds mohdros rosuetinds

ob KAQK auibnd utkekzcimds ospormitdzdknos tostkaueiros

Ovieuimds 361 akaeds no KAQK, adrrospdbnkobtos ie id 3:9:,ob eds quo so roiekz i eds virdbos oe tost no fri`mobtiakb noe

INB ospormtkad

^abkai no nksporskb no eiardmitkbi ospormtkai (QAN) adboe lkt Giedsporm (Giedtoag).


85/97

Qk NFK 5 1:% Bd pitde`kad

Qk NFK 1:% Zitde`kad

ID 3:9:


86/97

No eds 361 ^ost no Fri`mobtiakb noe NBI roiekzinds

90: bd pitde`kads;1 pitde`kads (1?%)

^F 3:9:

BD Z I^DE@KADQ

ZI^DE@KADQ

^dnds eds piakobtos adb NFK pitde`kad fuordbtritinds adb ibtkdxknibtos drieos

ID 3:9:


87/97

ID 3:9:

No eds ;1 pitde`kads, tris tritimkobtd

>9 so bdrmiekzirdb?3 kbnkaiakb nockdpski tostkaueir(??,;%)

^F SI^IMKOB^D

BDSMIEKXINDQ

K. CKDZQKI


88/97

No eds ?3 adb kbnkaiakb no ckdpski tostkaueir

9; ckdpski tostkaueir(16,?%)

11 bd ckdpski

^SI^IMKOB^D

BD CKDZQKI

CKDZQKI


89/97

:

3

>

6

7

9:

93

9>

96

97

3:

CKDZQKI BD CKDZQKI

@OQÎAKB

BD @OQÎAKB

@OQÎAKDBOQ ADB NFK IEÔSIND

9; Aisds 11 Aisds


90/97

0>%

>3%

:

9:

3:

1:

>:

?:

6:

0:

7:

CKDZQKI

BD CKDZQKI

ÎQI NO @OQÎAKB ADB NFK IEÔSIND

p5 :.:9


91/97

ADBAE_QKDBOQ

Eds ospormitdzdknos tostkaueiros,ob aisds sovords, no ieti tisino fri`mobtiakb noe NBI ospormtkad, dctkobob mohdros tisis no`ostiakbmonkibto KAQK quo eds oyiaueinds.

Ob eds piakobtos adb ietitisi no fri`mobtiakb noe NBI(kbiaopticeos piri KAQK) y quo bd nksmkbuyo adb tritimkobtdmnkad so noco kbnkair ei oxtriaakb no ospormitdzdknos

tostkaueiros8 ^OQO piri KAQK.

Ckcekd`rifki8


92/97

_sd no ospormitdzdknos no tostaued

Qk os pdskceo ob ckdpskis ob frosad

Gum Soprdn. 3::? Hib omcirizds (>>,>% omcirizd 3:,0kmpeibtiakb), no eds ; no oyiaueind 9 omcirizd y icdrtd

NKQASOZIBAKIQ8Soprdn Ckdmon Dbekbo. 3::1 Dat-Bdv)8>>;-??.Offoats df arydprosorvitkdb db tostkaueir sporm buaeoir NBI fri`mobtitkdb ibn kts roeitkdbsgkp wktgisskston adbaoptkdb dutadmo fdeedwkb` KAQK wktg tostkaueir spormitdzdi.^gdmpsdb-Aroo MO, MaAeuro B, Ndbboeey O , Qtooeo LO, Eowks QO.Bd obauobtrib nkforobakis ob ei tisi no foaubniakb, no nkvkskb y ei mdrfded`i omcrkdbirki. Ei tisi noomcirizd adb frosadsos noe 1:% y adb adb`oeindsnoe 36% , bd sdb ostinkstkaimobto sk`bkfkaitkvis

SOFEOWKDBOQ8
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Scarselli%20F%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Iacobelli%20M%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Rienzi%20L%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ubaldi%20F%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ferrero%20S%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Franco%20G%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Anniballo%20N%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Mendoza%20C%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tesarik%20J%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22McClure%20N%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Donnelly%20ET%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Steele%20KE%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lewis%20SE%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Lewis%20SE%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Steele%20KE%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Donnelly%20ET%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22McClure%20N%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Tesarik%20J%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Mendoza%20C%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Anniballo%20N%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Franco%20G%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ferrero%20S%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Ubaldi%20F%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Rienzi%20L%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Iacobelli%20M%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlushttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Scarselli%20F%22[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus


93/97

9. Ei Fri`mobtiakb (bnkao Fri`mobtiakb noe NBI NFK) bd os sedub adbaoptd osttkad

3. Eis nkforobtos pitded`is d aiusis puonob ifoatir bd sed i eifri`mobtiakb, timckb i su nkbmkai (NFN), y no fdrmi nkforobto

1. Zuono gicor mohdris d ompodrimkobtds nkforobakinds no eds nds

pirmotrds8 NFK - NFN4>. Zdnri ie`b tritimkobtd sor cobofkakdsd piri NFK pord bd piri NFN4

?. Os sufkakobto adb mohdrir ubd no eds pirmotrds4

6. Auie os oe pipoe no eds Ibtkkbfeimitdrkds y Ibtkdxknibtos ob NFN4

0. Nkforobtos ibtkdxknibtos piri aini fiatdr4

7. Yuoni muagd pdr adbdaor

ADBAE_QKDBOQ ZSIA^KAIQ


94/97

9. Nki`bdstkairaiusis pdtobakiemobto triticeosy tritireis3. Qkompro8

Mdnkfkair gcktds txkads. Adbsohds gk`kbkad- nkottkads

Oyiaueiakdbos sorkinis(nkforobto noe ostbnir no road`kni)

Zrkmori friaakb no oyiaueind Mkbkmkzir tkompdseicdritdrkd obtro road`kni y usd

1. Qk bd giy aiusi triticeo8

Ibtkkbfeimitdrkds (nkaedfobiad ?: m`/93 g. ob tibnis no 9? nis)

Qoeoaakbno ospormitdzdknos8 KMQK, Adeumbis iboxkbi, ota. Ckdpski tostkaueir

IB^KDWKNIB^OQ


95/97

Giceir no Mibohd no ei Fri`mobtiakb, os giceir noe8Zipoe noe _red`d d Ibnred`d ob Soprdnuaakb

Adbaoptds8

Ei ori no ei KAQK y ei Fri`mobtiakdb noe NBI.

Oe aimckd no dchotkvd noe Ibnred`d8

Ibnred`d noe ospormitdzdkno

Buovd Zirink`mi


96/97

Mohdri noe Virb Nksfubakdbos soxuieos y oyiaueitdrkis

Ietoriakdbos ibitmkais8 pobo, moitd, ota.

Mohdri noe Qomob8 Adbaobtriakb8 Izddspormki, Dek`d., Zdek., ...

Aieknin8 Istobd., Board., ^oritd, ...

Zeismi somkbie8 Vdeumob, pG,...

Mohdri noe @imotd8 Ardmdsmkais

Mdeoaueiros @obtkais

Fri`mobtiakb noe NBI


97/97

Muagis `riakis pdr su itobakb!

www.ibnrdmonk.adm

baruzJ`mx.os

ADDSNKBINDS BIAKDBIE IBNSDED@KI

Nr. Bitiekd Aruz

Documents

Natalio Cruz - Fragmentación ADN - II Simposio Reproducción Asistida Quirón