Neurodegenerative Disease

A Multi Therapeutic Approach

The Nervous System

• Central Nervous System

– Brain

• Cerebrum

• Cerebellum

• Mid Brain

• Brain Stem

– Spinal Cord

The Nervous System

• Peripheral Nervous System – Spinal Nervous system

– Autonomic Nervous System • Sympathetic Nervous System

• Parasympathetic Nervous System

• Multiple Plexuses – Enteric

– Solar

– Brachial

Keep the Nervous System Healthy

• 11 Essentials To Wellness (O.W.N.N.E.R.S)

– Oxygen

– Water

– Nutrition

– Nervous system Stimulation

– Exercise

– Rest

– Sunlight

Keep the Nervous System Healthy

• 11 Essentials To Wellness (P.L.U.S.)

– Positive Mental Attitude

– Laughter

– Unconditional LOVE

– Simplicity

Cells of the Brain

• Neurons- CNS functional Cells

• Astrocytes- structure, biochemical, blood

– brain barrier support, repair, protect

• Oligodendrocytes- create myelin sheath

• Microglia-Brain macrophages phagocytize

– cell debris, waste and pathogens

• Ependymal- CSF and Spinal brain barrier

Neuron Still a cell like other cells

1. Stroma- Body of the Cell

2. Dendrites- Tendrils receiving signals

3. Axon- Long projection carrying signal

Synapse

What are Neurotransmitters

• Transmit signals across a synapse from one neuron (nerve cell)

• to another 'target' neuron.

• 100+

• Excitatory and Inhibitory

• Emotion, Learning, Memory, Circadian Rhythm,

• Motor skills, Reward, Mood, Appetite, Sensory

• Second Brain

• Endocrine

6 Classes of Neurotransmitters

• Acetylcholine

• Amino acids: Gamma-aminobutyric acid (GABA) and – Glycine Glutamate Aspartate.

• Neuropeptides: Oxytocin,endorphins, vasopressin, etc.

• Monoamines: Epinephrine, norepinephrine, histamine, – dopamine and serotonin.

• Purines: Adenosine, ATP.

• Lipids and gases: Nitric oxide, Hydrogen Sulfide, – cannabinoids.

The Fastest Growing Disease

• Parkinson and Alzheimer's Disease are now the fastest growing diseases in the US

• PD

– 60,000 new cases each year

– 10 million world wide cases current

• Alzheimer’s

– The number one concern for people over 60

– 30 million Global cases,

The Fastest Growing Disease

• Parkinson and Alzheimer's Disease are now the fastest growing diseases in the US

• Alzheimer’s

– The number one concern for people over 60

– 30 million Global cases

– 5.4 million US

– 3rd cause of death

Causes

• Amyloid B and Tau Proteins • Inflammatory mediators • Lipid metabolism factors • Hormonal mediators • Tropic factors and their receptors • Calcium regulatory pathways (NO/ONOO) • Axoplasmic transport • Neurotransmitters and their receptors • Prion Protein

4 Causes in a Nutshell

• Metabolic disorders

– Glucose, Insulin and Glycation

– Metabolic enhancement for neurodegenerative disorders

• Toxins

– Heavy Metals

– Glyphosate

4 Causes in a Nutshell

• Brain nutrient deficiencies – Fats

– Iodine

– B12

– MTHF (B9 Folic acid) 1/3 Americans genetic variation that impairs proper utilization

– Antioxidants

– GSH (Glutathione)

– Redox Signaling

4 Causes in a Nutshell

• Gut Bacteria

– Needed for neurotransmitter synthesis

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All 4 causes are associated with inflammation

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Warning on Glyphosate

• Multi causative toxin

– Effects the Shikamate Pathway that makes Neurotransmitters

– Puts holes in gut that drive autoimmune

• The real cultrate in beta amyloidal

– Disrupts the P450 detox pathway

– Heightens the toxicity of heavy metals

– Disrupts Cholesterol sulfate pathway

Glyphosate Usage

• 2 fold increase in last 5 yrs

• It is in 60% of air and soil samples

• Being used on all conventional grain to increase harvest

• Found in ALL humane blood and urine

Dementia and Glyphosate

Alzheimer’s

Cholesterol sulfate (C/S) protects the cells from “ion-leaks”

• “Ion-leaks” cause massive drops in ATP

• C/S plays a major role in cell to cell communication

• Responsible for brain synapses and memory

• C/S deficiency causes an increase in brain insulin and

glucose leading to Alzheimer’s (It’s now considered type 3

diabetes)

– Affects the lipid rafts (insulin resistance)

Cholesterol Sulfate Deficiency

A modern-day epidemic responsible for not just heart disease, but multiple other degenerative diseases… • Leaky gut and its many associated conditions such

as autoimmune • Autism • Alzheimer's, dementia and Parkinson's • Depression • Diabetes

Sulfate Transport

• 7 different ways… 1. Cholesterol sulfate 2. Serotonin sulfate 3. Dopamine sulfate 4. Estrone sulfate 5. DHEA sulfate 6. Vit D sulfate 7. Melatonin sulfate Glyphosate disrupts sulfate transfer and depletes serotonin

and dopamine by disrupting enzymes involved with sterol

sulfation

Glyphosate: Some Biological Effects

• Depletes aromatic amino acids (via Shikamate • Pathway) • Tryptophan serotonin melatonin • – Serotonin deficiency is linked to obesity, autism, • Alzheimer’s disease, depression, and violent behavior • – Melatonin controls sleep/wake cycle (glyphosate also • poisons the penal gland outside the BBB) • – Tryptophan deficiency is linked to depression • Tyrosine dopamine, adrenaline, melanin, thyroid • hormone • – Dopamine deficiency leads to Parkinson’s disease • – Melanin in skin protects from UV exposure

C. Elegans Study: Parkinson's Disease

• Chronic exposure to glyphosate led to degeneration of

– dopaminergic and GABAergic neurons (in brainstem nuclei)

Wheat desiccated with Roundup

High fructose GMO corn syrup

GMO soy protein filler

GMO Canola Oil

Cows fed GMO corn and soy Potatoes

desiccated with herbicides

In the diet

• Soy protein isolates and textured vegetable proteins are loaded…

• Protein isolate and soy lecithin are loaded with glyphosate…

Poisoning our Seniors

• Liquid Vanilla: • Water, Sugar, Corn Maltodextrin, Sodium Caseinate, • Milk Protein Concentrate, Soy Oil, Soy Protein • Isolate, Corn Oil, Potassium Citrate, Calcium Beta- • Hydroxy-Beta-Methylbutyrate, Canola Oil. Less than 0.5% • of the Following: Whey Protein Concentrate, • Magnesium Phosphate, Natural & Artificial Flavor, Cellulose • Gel, Soy Lecithin, Sodium Phosphate, Potassium • Phosphate, Potassium Chloride, Choline Chloride, Ascorbic • Acid, Calcium Carbonate, Cellulose Gum, Carrageenan, • Ferrous Sulfate, Salt, dl- Alpha-Tocopheryl Acetate, Gellan • Gum, Zinc Sulfate, Niacinamide, Calcium Pantothenate, • Manganese Sulfate, Cupric Sulfate, Vitamin A Palmitate, • Thiamine Chloride Hydrochloride, Pyridoxine Hydrochloride, • Riboflavin, Folic Acid, Chromium Chloride, Biotin, Sodium • Molybdate, Sodium Selenate, Potassium Iodide, • Phylloquinone, Cyanocobalamin, and Vitamin D3

Recent Publication by Dr. Stephanie Seneff

MTA Study The Multi Therapeutic Approach

MTA Study

• 9 out of 10 improved subjectively and objectively in 3-6 months

• 6 were not able to work before the study

• All were able to return to work

• Improvements sustained for 2.5 years

The Protocol

• Diet

– Intermitentant Fasting

– Utilizing Ketosis

– High fats

– variation

The Protocol

• Exercise

– High intensity

– Burst Exercise

The Protocol

• Nutrients and Hormones

– Fats : Omega 3 and 6 in a 4:1 ratio

– MCT (medium Chain triglycerides)

• Coconut oil

• Palm oil

The Protocol

• Nutrients and Hormones

– Functional Nutrients

• Iodine

• B 12

• MTHF (B9)

• Antioxidants

• GSH (Glutathione)

– Gut Bacteria

– Brain Detox (True Cellular Detox) with phases

Exercise

• 1. High Intensity (Burst)

• 2. Resistive training (body weight or weights)

• – Both are high intensity and both are shown to have a

• greater impact on the brain and glucose metabolism

Nutrients and Products

• Recall from study… • – Melatonin (sulfate distribution), DHEA, Vit D (inflammation and • cholesterol sulfate synthesis) and consider progesterone…(DV3, • New CALM product and others) • – Methylcobolamine, MTHF, peridoxine-5-phosphate, D3, CoQ10,

Zn, • ALA…(MORS, eNRG, GCEL) • – Antioxidants… (rotate EPIC and ROX, Redox) • – DHA / EPA’s and phosphatidylcholine / citicoline…(rotate VISTA, • CVO and X Factor, Coconut and MCT oils) 4:1 ratio

Holistic Approach to Cognitive Health

Neuroplasticity

• Collateralization (branching)

• Learning

• Large-scale cortical remapping in

• response to environment

• Improving Memory

• Recovery from brain damage

Bacteria

• 1. Must eliminate glyphosate

• • No grains or at least organic ancient grain in

• moderation

• 2. Fermented foods

• • Intermittent fasting with re-inoculation phases

• 3. Rotate your bacteria

• • MBC, Ec and soon FMT pill as well as fermented

• foods

Brain Detox

• Toxins drive…

• • Brain inflammation

• • NO/ONOO

• • Trigger genes associated with neuron degeneration

• • Kills bacteria needed for neurotransmitters

• • Disrupts cholesterol sulfate need for brain function

Aluminum and mercury are the biggest culprits

• The flu shot push, esp. now with pregnant mothers and • infants • • Enters the penal gland (it is outside the BBB), which • produces melatonin the transporter for sulfate to the • brain…causes a melatonin and brain sulfate deficiency • • This disrupts REM sleep, normal brain activity,

needed • sulfate for all neuron function, and further effects the • detox of heavy metals • • Remember glyphosate accentuates heavy metals by • transporting them through the BBB to the pituitary

Other Brain problems

• Anxiety

• • Sleep

• • Weight gain

• • Depression

• • Neurodegeneration

• ADD

• ADHD

• Obsessive Compulsive behavior

• Bi-Polar

• Personality Health

Mood Dysfunction Stats

• Anxiety disorders are the most common mental • illness in the U.S., affecting 40 million adults in • the United States age 18 and older (18% of U.S. • population) • Anxiety disorders cost the U.S. more than $42 • billion a year • Anxiety disorders develop from a complex set

of • risk factors, including genetics, brain chemistry, • personality, and life events

• Cortisol is a big part of weight gain esp. in those • hard to lose areas… • CALM • • has an effect on anabolic hormones opposite of cortisol, • which is catabolic in nature…supports methylation, • testosterone, growth hormone and the adrenal pituitary • axis • • Contains adaptogens needed for endocrine weight loss • resistance • • Combined with the right supplant support and diet and • CALM could be referred to as a weight loss product

Depression

• Massive drop in tryptophan • – The dysbiosis caused by glyphosate killing good bacteria • up-regulates macrophages to kill the bad bacteria • – Glyphosate also destroys tryptophan in the plants and the • gut • – The macrophages need tryptophan to protect themselves • from the chemicals they produce to kill bad guys. • – There is not enough tryptophan left to make serotonin • (needed for mood and appetite suppression) • • C/S is needed for all neurotransmitter, hormones • and brain function and a lack is linked to depression

Depression

• perfect depression protocol… • • DHEA • • SAMe • • Tryptophan and 5-HTP (needed today more than ever • due to glyphosate) • • GABA and Taurine • • St johns Wart • • Rhodiola rosa and Ashwagandha • • Mucuna puriens (L DOPA) • • B6

Sleep and Anxiety

• Remember with sleep and anxiety it is always about

• neurotoxins up-stream. Brain detox is the real solution (metals

• in the penal gland and pituitary)

Heavy Metals and The Penal Gland

• Melatonin which is made in the penal gland transports • sulfate to the brain and nerve system • • With sun light the penal gland builds up sulfate by day and • produces melatonin at night transporting the sulfate as • melatonin sulfate to the brain • • Heavy metals such as Al and Hg have been shown to effect • the penal gland because of its location out side the BBB • • This causes a melatonin deficiency, which effects not just • REM sleep but the brain • • REM sleep and a calcified penal gland is associated with… • Alzheimer's, depression, ALS, Parkinson's and autism

Understanding Mood Dysfunction

• Mood Health is connected to Brain Health. (MS, AD,

• Dementia etc.)

• Neurotransmitter Imbalance (Anxiety-GABA; OCDSerotonin;

• SAD-norepinephrine)

• Membrane and Receptor Dysfunction (amygdala)

• Endocrine (cortisol)

• Xenobiotics

• Inflammation

• Second Brain G.I.

Anxiety Symptoms

• Tremors in the hands or feet

• Unresolved headaches

• Unexplained body aches

• Inability to concentrate for a long time

• Fainting spells

• Sweating episodes

• Disturbed sleep patterns

CALM

Mood Health Serotonin, Dopamine

and Norepinephrine Balance

Improve Brain Exercises

Increase Enzyme activity

Decrease oxidative stress

Receptor Sensitization

• Improves Synapse Response

• Increases Neuron Collateralization

• Changes all Neurotransmitter

• Feedback

• Decreases Resistance Issues

Influence Synapse Enzymes

• Changes in Synapse Enzymes leads to changes in Neurotransmitter

• impact which in turn leads to changes in behavior, neural processes,

• thinking, and emotions

Influence Synapse Enzymes

• Impacts Neurotransmitter Re-uptake

• Improves Neurotransmitter

• Degradation

• Increases Receptor Action

• Larger Vesicle Release

• Improving Memory

• Recovery from brain damage