Oncologia:novità su onco-metabolismi e connesse

terapie integrate fito bio-enzinutri-dinamiche.

PROBIOTICI:usi innovativi multiattivi e connesse terapie in

oncologia,gastroenteroL.,metab.,antietà,ecc.

NATURFIERA-CATANIA-8GIU.2013

PROF. CALOGERO RINZIVILLO

FARMACISTA-MEDICO SPECIALISTA3394201756-3293178092-0953782378

095435565-RINZIVIL@UNICT.ITTNUCLI@POLICLINICO.UNICT.IT

VICEPRES.AMIFIT-ASS.IT.MED.INTEGR.FITOT.-

Az. Osped.Universit.Policlinico Vittorio Emanuele-Edif.4-via S. Sofia- Catania

Presidente Dr.a Patrizia TostoPresidente Dr.a Patrizia Tosto

14 Apr.2013-Paradiso Etna-1°CongressoNaz. A.M.I.Fit.

Ass.Italiana Medicina Integrata e Fitoterapia-

2

Prof. C. RinzivilloProf. C. Rinzivillo

(Passione,studio NutriFitoInt.e ter.nat.integr.daì76 =oltre 35anni)

(Cent. m.: Erythraea centaurium, fosfat. col.)

Lauree:Farmacia, Medic.e Special.max voti,lode e proposta premi

Premio Fondazione Internazionale “G.GALILEI” (Ginevra) e Premio Lions per ricerca medica e nutrizione; Relazione premiata Congresso Nazionale ADI-Giardini-Ass.Diet.Nutr.Clin.(uso integratori alimentari e cofattori e proteine in operati oncologici stomizzati, preventive o per deficit nutrizionali)

Oltre 150 pubblicazioni scientifiche su temi di gastroenterologia, nutrizione clinica, supporto in chirurgia, gastroent.,oncologia, malattie metaboliche,medicina benessere e antinvecch.,fito-nutri-int.

Finanz.vari progetti Ateneo\Dip.:terapie mediche integrate,in partic.paz.Chir.,Oncol.,App.dig.,Metab

già o attuale Socio varie Soc.Medico-Scientifiche, fra cui:° New York Academy of Sciences, ° ADI-Ass. Ital.Diet.Nutriz.Clinica, ° SINPE Soc.Ital. Nutrizione Parent. Enterale, ° AIOT- Ass.It.OmeoTossic.-Medic.Biologica- MEDIBIO; °MASTER Annuale e socio AMIDEAV Ass.Medica Ital.Elettr.Agopunt.; ecc.

Resp.1°Prog.Ricerca Finaliz.Sanit.Reg.”NUTRI-FITOINTEGRAT. IN PAZ. CHIRURG.,ONCOL.,DISMETAB.”3

ONCOLOGIA principio attivo antiinfiammat.della  curcuma,tradizionale per secoli AY,MTCinese. capacità curcumina causare apoptosi solo negli ONCOCITI mentre miglioravan funzioni

‘normali’ di cellule normali-ANDERSON CANCER CENTER TEXAS 2011 Ciò è confermato da Ospedale Zheijian-Cina, in particolare apoptosi in cellule del BC

cancro mammario TNBC=triplo negativo (recettori E,P, EGrF), più difficile da curare dei BC recett.+.

Tale effetto è potenziato se si usano cibi e integratori ricchi di flavanoli, in particolare epigallocatechina gallato (EGCG) del tè verde, effetti ottimi antiox e anti-neoangiogenetico antiflog.se  usato con diferuloilmetano da curcumina.

SITI WWW. : -greenmedinfo.com/substance/curcumin; naturalnews.com/037879_curcumin_cancer_cells_turmeric.html

ncbi.nlm.nih.gov/pubmed/23740392 (Singh&Misra.Interdisc.Sc.2013 June) (diferuloyl methane) and its naturally analogs demethoxy, bisdemethoxy and cyclocurcumin, present

in rhizomes of curcuma species turmeric, inhibit the proliferation of a wide variety of tumor cells.

AA.shows that Curcumin targets (EpiG.n)nuclear protein HPV16E6,major protein actively developing

oral&cervical K Curr Cancer Drug Targets,2013 Apr 17. [ahead of print], Clinical Oncology, Queen Elizabeth

Hospital- HONG KONG-By Wang Y e C.: Genetic And Epigenetic Studies For Determining Molecular Targets Of Natural Product Anticancer Agents->EGCG, curcumin, genistein, EGCG, curcumin, genistein, sulforaphane and resveratrolsulforaphane and resveratrol have anticancer properties through the mechanisms of altering epigenetic processes epigenetic processes [including DNA methylation, histone modification, chromatin remodeling, microRNA (miRNA) regulation] and targeting cancer stem cells cancer stem cells (CSCs)

ONCOLOGIA Chem.Commun.(Cambridge Press) 2013 Jul-Cl.study c3cc41858h. Ahead of PRINT . Ahead of PRINT Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor. by Margarucci L. e C.-Dipart.Farmacia Univ. Salerno-Hsp90 is a key target in cancer therapy. Oleocanthal, olive oil active compound, is its

inhibitor. Nutr Metab Cardiovasc Dis.2013 Feb 25.(ahead of print]Mediterranean diet and non enzymatic antioxidant capacity in the PREDIMED study:

Evidence for a mechanism of antioxidant tuning. By Zamora R.e C.

1-year of correct MED diet increases plasma TAC:TOTAL ANTIOXIDANT Capacity level. Colloids Surf B Biointerfaces.2013 Jun.Ahead of print.Elsevier

Scient.Intern.Publish. Spontaneous ultra fast synthesis of gold nanoparticles using Punica granatum for cancer targeted drug delivery.-By Ganeshkumar M.&C.-India-CSIR Counc.Scient.Ind.Res.

Free 5-Fu,vs 5Fu@Pun.NanoPs was investigated against MCF-7 cells (breast cancer)and we observed that amount of 5Fluoruracil(CH)required to achieve 50%of growth-inhibition was much lower VS free 5Fu.

->cytochrome P450 enzyme, CYP1B1, is a target in prostate cancer.Compounds inhibiting CYP1B1 activity are contemplated to exert beneficial effects at three stages of prostate cancer development, that is, initiation, progression, and development of drug resistance. Pomegr.ellagitannins/intest.microbial metabolites/: Urolithin A was the most potent uncompetitive inhibitor of CYP1B1,with a dual mode mechanism by decreasing CYP1B1 metabolic activity and expression (epigenetics). Punicalins and punicalagins exhibited potent CYP1A1 inhibition, also-J Agric Food Chem.2009 Nov<-Missisippi Un.->AND J Agric Food Chem.2010 Feb: Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins

ONCOLOGIA J Mol Endocrinol.2013 May 29. [Ahead of print]Antioxidant and anti-growth action of peracetylated oleuropein in thyroid

cancer Bulotta S.e C.phenolic components oleuropein and its derivatives.OLE inhibited significantly

proliferationThis effect was paralleled by a reduction of basal phospho-Akt and phospho-ERK levels

and H2O2induced ROS levels. A stronger effect by Ac-OLE in inhibiting cell growth and as

antioxidant(vitro). Cytotechnology.-2009 Jan;59(1) Anti-proliferative and apoptotic effects of

oleuropein and hydroxytyrosol on human breast cancer-University of Tsukuba-Japan-by Han J. & c.-

Effects of anthocyanidins (cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin) on the aryl hydrocarbon receptor (AhR)-CYP1A1 signaling pathway in human hepatic&intest.K cells.

Pelargonidin can bind to and activate the AhR and AhR-dependent gene expression, and pelargonidin and delphinidin inhibit the CYP1A1 catalytic activity

-UNIV. BARCELLONA (Zamora R. e C.) sta approfondendo DIETA MED.e effetti suoi principi attivi già dimostrati in vivo e vitro come antiox e antitum.di supporto PRINCIPI (MALVIDINA ecc.): vedi Br. J. Nutrition 2012 e altre riviste s

ONCOLOGIA

PASTEUR EFFECTWARBURG EFFECTREVERSE WARBURG EFFECT (LISANTI)CRABTREE EFFECT

NUTRIENTI ENZIMATIZZATI BIODINAMICI OTTIMIZZATI