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In Vitro Cell culture & screening
In Vivo Xenogra1 models
Ex Vivo μCT scanning & histology
Oncology Services
§ TumorScreenTM (60+ Cell Lines) • Prolifera:on • High sensi:vity
§ CaspaseScreen (60+ Cell Lines) • Apoptosis • 24 hour or custom assay
§ ComboScreenTM
• 5x5 or custom matrix • Combina:on index & Bliss analysis
§ 3D Screen for in vivo-‐like gene expression • Prolifera:on • Custom cell lines
§ Ability to translate tumor cell lines into xenograE studies
§ MulGple xenograE models for prostate, lung, colon, and liver cell lines
§ Other tumor types in development
§ Custom models available
§ OpGcal imaging & orthotopic models coming soon
§ High-‐resoluGon imaging & analysis of tumor vasculature • Tumor volume and surface area • Vessel volume, radius, tortuosity, branching, density, and distribu:on depth
§ Proprietary AltaBluTM imaging agent for 3D vascular analysis • Low toxicity • Safer, easier to work with, and permits more consistent perfusions
§ MulGple oncology and angiogenic markers of tumors for analysis using immunohistochemistry (IHC)
Vessel Radius
0
200
400
600
800
1000
1200
0 10 20
Tumor Volum
e (m
m3 )
Days Post Treatment
HT-‐29 XenograE
Control
Paclitaxel
§ Expert staff with 20 years experience § 8+ years of CRO experience, serving over 100 oncology clients
[email protected] www.NumiraBio.com Tel: 801-‐320-‐0682
3D Culture
All assays performed with a 9-‐concentra6on curve in quadruplicate with luminescent readout at 72hrs unless otherwise specified.