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KaK BH^HO H3 xa6jiHiibi, ua (J)onc JICHCHHJI TpaneKcaMOM PHCKxpOM6oxHHecKHx ocjio>KiieiiHM (no ; iauifbiM MHO) ne Bbipa^en, HXO

no4XBep>K,aaex jinxepaxypiibicxpanexcaMOBOH KHCJIOTLI.

o oe^onacnocxH

Ta6jiHua 4.1 IoKa3axejiH

TpOM6oiiHXbi

HopMa 180-320

I rpynna -rpancKcaM

N=30

II rpynna -KOHXpOJlb

N=30

l\O J IC4CI IHM

CHH^CCH %

HopMa %

HoBbimeH %

Me^Hana (KBapxHJin)

53,6

42,9

3,6

316,09(154-520)

51,4

48,6

-

280,8(179-360)

Hepes 24 naca

CHH^eH %

HopMa %

HoBbimeH %

Me^naHa (KBapxiuiw)

53,6

39,3

7,1

323,45(177-510)

30

50

20

234(169-263)

OueHKa M 3 M C I I C H M M 3a 24 Haca

CnH)KeHHe 3a 24 naca

(% Ha6jiio^eHHH)

CHH>KeHHe 3a 24 Haca B a6c3nan - Me^wana (KBapxHJin)

CHHacenne 3a 24 Haca

B % OX HCXO^H 3HaH

71,6

6,55 (-8,5)- (23)

5,8(~3,9)-(13,5)

40

-5,5

(-49)- (30)

-4,2

(-22,9) -(11, 5)

Ha 4»one npneMa npenapaxa oxMCscubi pa3nonanpaBJieHHbie H3MeHenn»

noKasarejieii. Bo BxopoM (anciuiOH-aMHHOKanpOHOBaa Kncjioxa) rpynne B

OXMCHCHO He6ojibixioe yBejiMHennc ypoBiui c GOJIMIIHM pasGpocoM, B OCHOBHOH -

He6ojibiuoe cHH^KCHHe napaivicxpa, TO>KC c GojibmviM pa36pocoM.

10

Ta6jmua 5. IIoKasaTenH AHTB

AMTB

HopMa 28-43

I rpynna -TpariCKcaM

N-30

II rpynna -KOHTpOJlb

N-30

1(0 J ICHCHHM

CHIDKCH %

HopMa %

HoBbimeH %

Me^Mana (KBapTHjra)

64,3

35,7

-

27,82(19,3-29,7)

68,5

41,5

-

25,05(23,2-27,6)

Hcpe3 24 naca

CHPDKCH %

HopMa %

noBbimeH %

MejiHana (KBapTHJin)

42,9

60,1

-

27,59(24-30,6)

70

30

-

27,4

(21,5-28,7)

qacTHHiioe TpOM6onnacTHHOBoe BpeMa HJIM AHTB3xo BpeMJi, sa KOTOpoe oGpasycTCJi crycroK KpoBH nocjre npiicoe^HHeHHa K

xjiopM^a Kajibuna H ^pyrnx peareiiTOB. AHTB - naii6ojieenoKa3aTeJib cBepTbmacMOCTH KPOBH, onpe^ensieMbiM npH

cHCTeMbi reMOcrasa. Mcxo;_ino HHSKHC 3HaneHHH riapaMexpOB Bo6enx rpynnax neMHoro no^pocjm na (})oiic

B rpynne nauneHTOB, nojiyqaiimnx jieneiiHe TpaneKcaMOM, HoprviajiM3auHsireMocxasa B TeneiiHe cyTOK BcrpenaeTca y 6ojibmero nncjia 6o^bHbix.

1 1

1. 3(J)4)eKTHBHOCTb TpaHeKcaMa B KOMmieKCHOH xepanHH jieroHHbixKpoBoxenemiH cymecxBCHHO Bbime, HCM y anciijioH-aMHHOKanpoHOBOH KHCJIOTW,KaK no ^aHHtiM KJiHHHHecKoro Ha6jiK>fleHHa, xaK H no /jaimbiM AHTB.

2. EesonacHocxb xpaneiccaMa o6ycnoBJiena Kax OXCVXCXBHCM BJIHHHHH HaTpOM6oo6pa3OBanHe, xaK H sa CHCT 6ojiee 6bicxpOH HopMajiHsaijHH reiuocxasa ,HTO 6bijio noKa3aHO B

3. HpenapaT TpaneKcaivi B KOMnjieKCHOH repanHH jieronHbixaBJiHCTca npenapaxoM BbiGopa, nosBOJisnomHM Ha^e^KHO H 6e3onacno ocxaHOBMTbjieroHHoe

4. HpHMeHeHHe npenapaxa TpaneKcaM coKpamaex nacxoxy onepaxuBHorojieroHHbix

Jlnxepaxypa1. Andersson L, Nilsson IM, Nilehn J-E, et al. Experimental and clinical studies onAMCA, the antifibrinolytically active isomer of p-aminomethyl cyclohexanecarboxylic acid. Scand J Haemal 1965;2:230-47.2. Bartholomew JR, Salgia R, Bell WR. Control of bleeding in patients withimmune and nonimmune thrombocytopenia with aminocaproic acid. Ann InternMedl989; 149:1959-1961.3. Can drugs reduce surgical blood loss? (editorial) Lancet 1988; 1:55-56.4. Coulter A., Kelland J., Long A. the management of menorragia. Effectivehealth Care Bull. 1995; 9: 1-14.5. Kobrinsky NL., Israels ED, Gerrard JM et al. Shortening of bleeding time by 1-deamino-8-D-arginine vasopressin in various bleeding disorders. Lancet 1984;1:1145-1148.6. Mannucci PM, Vicente V, Alberca I et al. Intravenous and subcutaneousadministration of desmopressin (DDAVP) to hemophiliacs: pharmacokinetics andfactor VIII responses. Thromb Haemost 1987; 58:1037-1039.7. Melander B, Gliniecki G, Granstrand B, et al. Biochemistry and toxicology ofAmikapron*:the antifibrinolytically active isomer of AMCHA (a comparativestudy with eaminocaproic acid). Acta Pharmacol Toxicol 1965;22:340-52.8. Okamoto S, Okamoto U. Amino-rnethyl-cyclohexane-carboxylic acid:AMCHA. A new portent inhibitor of the fibrinolysis. Keio J Med 1962;! 1:105-15.

Med 1989; 149:1959-1961.3. Can drugs reduce surgical blood loss? (editorial) Lancet 1988; 1:55-56.4. Coulter A. , Kelland J., Long A. the management of menorragia. Effectivehealth Care Bull. 1995; 9: 1-14.5. Kobrinsky NL., Israels ED, Gerrard JM et al. Shortening of bleeding time by 1-deamino-8-D-arginine vasopressin in various bleeding disorders. Lancet 1984;1:1145-1148.6. Mannucci PM, Vicente V, Alberca I et al. Intravenous and subcutaneousadministration of desmopressin (DDAVP) to hemophiliacs: pharmacokinetics andfactor VIII responses. Thromb Hacmost 1987; 58:1037-1039.7. Melander B, Gliniecki G, Granstrand B, ct al. Biochemistry and toxicology ofAmikapron*:the antifibrinolytically active isomer of AMCHA (a comparativestudy with eaminocaproic acid). Acta Pharmacol Toxicol 1965;22:340-52.8. Okamoto S, Okamoto U. Amino-rnethyl-cyclohexane-carboxylic acid:AMCHA. A new portent inhibitor of the fibrinolysis. Keio J Med 1962;! 1:105-15.

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