contact

PD Dr. Emmanuella Guenova

titel PD Dr. Dr.

first name Emmanuella

last name Guenova

country Switzerland

e-mail emmanuella.guenova@kssg.ch

2

publications

title

journalpaper/review

Sönnichsen A, Saulite I, Mangana J, Kerl K, Mehra T, Desislava I, Chang YT, Petrausch U, Schmid-Grendelmeier P, Hoetzenecker W, Cozzio A,Guenova E. Interleukin-1 receptor antagonist (anakinra) for Schnitzlersyndrome. J Dermatolog Treat 2016;1-3.

Hoetzenecker W, Mehra T, Saulite I, Glatz M, Schmid-Grendelmeier P,Guenova E, Cozzio A, French L E. Toxic epidermal necrolysis. F1000Res2016; 5:.

Saulite I, Hoetzenecker W, Weidinger S, Cozzio A, Guenova E, WehkampU. Sézary Syndrome and Atopic Dermatitis: Comparison ofImmunological Aspects and Targets. Biomed Res Int 2016;2016:9717530.

Flux K, Kutzner H, Rütten A, Plaza J A, Gasparov S, Michal M, Guenova E,Kazakov D V. Infundibulocystic Structures and Prominent SquamousMetaplasia in Sebaceoma-A Rare Feature. A Clinicopathologic Study of 10Cases. Am J Dermatopathol 2016;.

Thurneysen S, Cheng P F, Nagel H W, Kunz M, Jaberg-Bentele N, NägeliM, Ziegler M, Guenova E, Goldinger S M, Mangana J, Levesque M P,Dummer R. An exploratory study investigating the metabolic activity andlocal cytokine profile in melanoma patients treated with pazopanib andpaclitaxel. Br J Dermatol 2016;.

Konstantinova A M, Shelekhova K V, Stewart C J, Spagnolo D V, KutznerH, Kacerovska D, Plaza J A, Suster S, Bouda J, Pavlovsky M, KyrpychovaL, Michal M, Guenova E, Kazakov D V. Depth and Patterns of AdnexalInvolvement in Primary Extramammary (Anogenital) Paget Disease: AStudy of 178 Lesions From 146 Patients. Am J Dermatopathol 2016;.

3

publications

title

journalpaper/review

Guenova E, Ignatova D, Chang Y T, Contassot E, Mehra T, Saulite I,Navarini A A, Mitev V, Dummer R, Kazakov D V, French L E, HoetzeneckerW, Cozzio A. Expression of CD164 on Malignant T cells in SézarySyndrome. Acta Derm Venereol 2016; 96:464-7.

Konstantinova A M, Michal M, Kacerovska D, Spagnolo D V, Stewart C J,Kutzner H, Zelger B, Plaza J A, Denisjuk N, Hejda V, Shelekhova K,Bisceglia M, Danis D, Zamecnik M, Kerl K, Guenova E, Kazakov D V.Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From261 Patients, With Emphasis on Mammary-Type Alterations. Am JDermatopathol 2016;.

Kunz M, Urosevic-Maiwald M, Goldinger S M, Frauchiger A L, Dreier J,Belloni B, Mangana J, Jenni D, Dippel M, Cozzio A, Guenova E,Kamarachev J, French L E, Dummer R. Efficacy and safety of oralalitretinoin in severe oral lichen planus--results of a prospective pilotstudy. J Eur Acad Dermatol Venereol 2015; 30:293-8.

Kleffel S, Posch C, Barthel S R, Mueller H, Schlapbach C, Guenova E, ElcoC P, Lee N, Juneja V R, Zhan Q, Lian C G, Thomi R, Hoetzenecker W,Cozzio A, Dummer R, Mihm M C, Flaherty K T, Frank M H, Murphy G F,Sharpe A H, Kupper T S, Schatton T. Melanoma Cell-Intrinsic PD-1Receptor Functions Promote Tumor Growth. Cell 2015; 162:1242-56.

Mehra T, Guenova E, Dechent F, Würth F, Zierhut M, Röcken M, SchallerM, Deuter C. Diagnostic relevance of direct immunofluorescence in ocularmucous membrane pemphigoid. J Dtsch Dermatol Ges 2015;13:1268-74.

4

publications

title

journalpaper/review

Mehra T, Ikenberg K, Moos R M, Benz R, Nair G, Schanz U, HaralambievaE, Hoetzenecker W, Dummer R, French L E, Guenova E, Cozzio A.Brentuximab as a treatment for CD30+ mycosis fungoides and Sézarysyndrome. JAMA Dermatol 2015; 151:73-7.

Hoetzenecker W, Nägeli M, Mehra E T, Jensen A N, Saulite I, Schmid-Grendelmeier P, Guenova E, Cozzio A, French L E. Adverse cutaneousdrug eruptions: current understanding. Semin Immunopathol 2015;38:75-86.

Guenova E, Skabytska Y, Hoetzenecker W, Weindl G, Sauer K, Tham M,Kim K W, Park J H, Seo J H, Ignatova D, Cozzio A, Levesque M P, Volz T,Köberle M, Kaesler S, Thomas P, Mailhammer R, Ghoreschi K, Schäkel K,Amarov B, Eichner M, Schaller M, Clark R A, Röcken M, Biedermann T.IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencingof IL-23 in antigen-presenting cells. Proc Natl Acad Sci USA 2015;112:2163-8.

Amann V C, Dreier J, Ignatova D, Kamarashev J, Kerl K, Kempf W,Pascolo S, Dummer R, Cozzio A, Guenova E. Disseminated PrimaryCutaneous CD8+ Small/Medium-sized Pleomorphic T-cell LymphomaResponding to Hydroxychloroquine. Acta Derm Venereol 2015; 95:602-3.

Mehra T, Hoetzenecker W, Moos R, Volbracht J, Guenova E, French L E,Hafner J. Inpatient Treatment for Severe Nonsurgical DermatologicalDisorders: Prevalence, Care Infrastructure and Reimbursement inSwitzerland. Dermatology (Basel) 2015; 231:260-8.

DeSimone J A, Sodha P, Ignatova D, Dummer R, Cozzio A, Guenova E.Recent advances in primary cutaneous T-cell lymphoma. Curr Opin Oncol2015; 27:128-33.

5

publications

title

journalpaper/review

Bentele-Jaberg N, Guenova E, Mehra T, Nägeli M, Chang Y T, Cozzio A,French L E, Hoetzenecker W. The Phytotherapeutic Fenugreek as Triggerof Toxic Epidermal Necrolysis. Dermatology (Basel) 2015; 231:99-102.

Kaesler S, Volz T, Skabytska Y, Köberle M, Hein U, Chen K M, Guenova E,Wölbing F, Röcken M, Biedermann T. Toll-like receptor 2 ligands promotechronic atopic dermatitis through IL-4-mediated suppression of IL-10. JAllergy Clin Immunol 2014; 134:92-9.

Guenova E, Schanz S, Hoetzenecker W, DeSimone J A, Mehra T, VoykovB, Urosevic-Maiwald M, Berneburg M, Dummer R, French L E, Kerl K,Kamarashev J, Fierlbeck G, Cozzio A. Systemic corticosteroids forsubcutaneous panniculitis-like T-cell lymphoma. Br J Dermatol 2014;171:891-4.

Mehra T, Grözinger G, Mann S, Guenova E, Moos R, Röcken M, ClaussenC D, Dummer R, Clasen S, Naumann A, Garbe C. Primary localization andtumor thickness as prognostic factors of survival in patients with mucosalmelanoma. PLoS ONE 2014; 9:e112535.

Schlapbach C, Gehad A, Yang C, Watanabe R, Guenova E, Teague J E,Campbell L, Yawalkar N, Kupper T S, Clark R A. Human TH9 cells areskin-tropic and have autocrine and paracrine proinflammatory capacity.Sci Transl Med 2014; 6:219ra8.

Skabytska Y, Wölbing F, Günther C, Köberle M, Kaesler S, Chen K M,Guenova E, Demircioglu D, Kempf W E, Volz T, Rammensee H G, SchallerM, Röcken M, Götz F, Biedermann T. Cutaneous innate immune sensing ofToll-like receptor 2-6 ligands suppresses T cell immunity by inducingmyeloid-derived suppressor cells. Immunity 2014; 41:762-75.

6

publications

title

journalpaper/review

Guenova E, Hoetzenecker W, Rozati S, Levesque M P, Dummer R, CozzioA. Novel therapies for cutaneous T-cell lymphoma: what does the futurehold?. Expert Opin Investig Drugs 2014; 23:457-67.

Voykov B, Deuter C, Zierhut M, Leitritz M A, Guenova E, Guenova-Hötzenecker E, Doycheva D. Is cyclophotocoagulation an option in themanagement of glaucoma secondary to Fuchs' uveitis syndrome?.Graefes Arch Clin Exp Ophthalmol 2014; 252:485-9.

Schweiger T, Kollmann D, Nikolowsky C, Traxler D, Guenova E, Lang G,Birner P, Klepetko W, Ankersmit H J, Hoetzenecker K. Carbonic anhydraseIX is associated with early pulmonary spreading of primary colorectalcarcinoma and tobacco smoking. Eur J Cardiothorac Surg 2013; 46:92-9.

Saulite I, Voykov B, Mehra T, Hoetzenecker W, Guenova E. Incidentalfinding of lamellar calcification of the falx cerebri leading to the diagnosisof gorlin-goltz syndrome. Case Rep Dermatol 2013; 5:301-3.

Guenova E, Watanabe R, Teague J E, DeSimone J A, Jiang Y, DowlatshahiM, Schlapbach C, Schaekel K, Rook A H, Tawa M, Fisher D C, Kupper T S,Clark R A. TH2 cytokines from malignant cells suppress TH1 responsesand enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma.Clin Cancer Res 2013; 19:3755-63.

Dummer R, Rozati S, Guenova E, Cozzio A. Less can be more: the impactof chemotherapy on cutaneous T-cell lymphomas. Future Oncol 2013;9:1061-4.

Hoetzenecker K, Mitterbauer A, Guenova E, Schweiger T, Altmann P,Zimmermann M, Hofbauer H, Beer L, Klepetko W, Ankersmit H J. Highlevels of lung resident CD4+CD28null cells in COPD: implications ofautoimmunity. Wien Klin Wochenschr 2013; 125:150-5.

7

publications

title

journalpaper/review

DeSimone J A, Guenova E, Carter J B, Chaney K S, Aldridge J R, Noell CM, Dorosario A A, Hansen J L, Kupper T S, Devlin P M. Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma. J Am Acad Dermatol 2013; 69:61-5.

Volz T, Skabytska Y, Guenova E, Chen K M, Frick J S, Kirschning C J,Kaesler S, Röcken M, Biedermann T. Nonpathogenic bacteria alleviatingatopic dermatitis inflammation induce IL-10-producing dendritic cells andregulatory Tr1 cells. J Invest Dermatol 2013; 134:96-104.

Berneburg M, Herzinger T, Rampf J, Hoetzenecker W, Guenova E, MeisnerC, Maetzke J, Schaefer T, Eberlein B, Scharffetter-Kochanek K, Rocken M.Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA inpsoriasis: a prospective, open, randomized, multicentre study. Br JDermatol 2013; 169:704-8.

Hoetzenecker W, Guenova E, Krug M, Goetz A, Amarov B, Haefner H M,Breuninger H. Parental anxiety and concern for children undergoingdermatological surgery. J Dermatolog Treat 2013; 25:367-70.

Guenova E, Hoetzenecker W, Kisuze G, Teske A, Heeg P, Voykov B,Hoetzenecker K, Schippert W, Moehrle M. Banana leaves as an alternativewound dressing. Dermatol Surg 2012; 39:290-7.

Guenova E, Hoetzenecker W. Case 1-2012: a man with persistent ulcerson the hands. N Engl J Med 2012; 366:1450; author reply 1450.

Schanz S, Schmalzing M, Guenova E, Metzler G, Ulmer A, Kötter I,Fierlbeck G. Interstitial granulomatous dermatitis with arthritisresponding to tocilizumab. Arch Dermatol 2012; 148:17-20.

8

publications

title

journalpaper/review

Hoetzenecker W, Echtenacher B, Guenova E, Hoetzenecker K, Woelbing F,Brück J, Teske A, Valtcheva N, Fuchs K, Kneilling M, Park J H, Kim K H,Kim K W, Hoffmann P, Krenn C, Hai T, Ghoreschi K, Biedermann T, RöckenM. ROS-induced ATF3 causes susceptibility to secondary infections duringsepsis-associated immunosuppression. Nat Med 2011; 18:128-34.

Feldmeyer L, Guenova E, Torres T, Nosbaum A. Residents'corner July2011. Eur J Dermatol 2011;.

Guenova E, Teske A, Fehrenbacher B, Hoerber S, Adamczyk A, SchallerM, Hoetzenecker W, Biedermann T. Interleukin 23 expression inpyoderma gangrenosum and targeted therapy with ustekinumab. ArchDermatol 2011; 147:1203-5.

Guenova E, Hoetzenecker W. Treatment of recurrent aphthous stomatitiswith fumaric acid esters. Arch Dermatol 2011; 147:282-4.

Feldmeyer L, Guenova E, Torres T, Nosbaum A. Residents'corner July2011. Eur J Dermatol 2011;.

Volz T, Nega M, Buschmann J, Kaesler S, Guenova E, Peschel A, RöckenM, Götz F, Biedermann T. Natural Staphylococcus aureus-derivedpeptidoglycan fragments activate NOD2 and act as potent costimulatorsof the innate immune system exclusively in the presence of TLR signals.FASEB J 2010; 24:4089-102.

Guenova E, Volz T, Eichner M, Hoetzenecker W, Caroli U, Griesinger G,Burow G, Mitev V, Biedermann T. Basal serum tryptase as riskassessment for severe Hymenoptera sting reactions in elderly. Allergy2010; 65:919-23.

Guenova E, Lichte V, Hoetzenecker W, Woelbing F, Moehrle M, Roecken M,Schaller M. Nodular malignant melanoma and multiple cutaneousneoplasms under immunosuppression with azathioprine. Melanoma Res2009; 19:271-3.

9

publications

title

journalpaper/review

Hoetzenecker W, Guenova E, Hoetzenecker K, Yazdi A, Röcken M,Berneburg M. Successful treatment of recalcitrant lymphomatoidpapulosis in a child with PUVA-bath photochemotherapy. Eur J Dermatol2009; 19:646-7.

Voykov B, Guenova E, Sturm E, Deuter C. Alagille syndrome associatedwith myelinated retinal nerve fibers. Ophthalmologica 2009; 223:348-50.

Voykov B, Guenova E. Images in clinical medicine. Diagnostic finding inthe iris. N Engl J Med 2009; 361:e22.

Voykov B, Guenova E, Papageorgiou E, Heckl S, Schiefer U. Whentuberous sclerosis complex becomes an emergency. Can J Ophthalmol2009; 44:220-1.

Meier F, Guenova E, Clasen S, Eigentler T, Forschner A, Leiter U, ZielinskiC, Knaudt B, Garbe C, Berneburg M. Significant response after treatmentwith the mTOR inhibitor sirolimus in combination with carboplatin andpaclitaxel in metastatic melanoma patients. J Am Acad Dermatol 2009;60:863-8.

Guenova E, Metzler G, Hoetzenecker W, Berneburg M, Röcken M. ClassicMediterranean Kaposi's sarcoma regression with sirolimus treatment.Arch Dermatol 2008; 144:692-3.

Guenova E, Volz T, Sauer K, Kaesler S, Müller M R, Wölbing F, Chen K,Schwärzler C, Brossart P, Röcken M, Biedermann T. IL-4-mediated finetuning of IL-12p70 production by human DC. Eur J Immunol 2008;38:3138-49.

Guenova E, Genova S, Voykov B, Novakova S, Mitev V. Immunoglobuline-mediated anaphylaxis to sesame. World Allergy Organ J 2008; 1:134.

10

publications

title

journalpaper/review

Guenova E, Weber H O, Voykov B, Metzler G, Mitev V, Berneburg M,Hoetzenecker W, Röcken M. Palmar-plantar erythrodysesthesia secondaryto sunitinib treatment resulting in necrotic foot syndrome aggravated bybackground diabetic vascular disease. Arch Dermatol 2008; 144:1081-2.

Guenova E, Hoetzenecker W, Schaller M, Röcken M, Fierlbeck G. Tineaincognito hidden under apparently treatment-resistant pemphigusfoliaceus. Acta Derm Venereol 2008; 88:276-7.

Hoetzenecker W, Zipfel M, Guenova E, Hoetzenecker K, Rocken M.Vasculitic leg ulcers in a patient with mixed myelodysplastic andmyeloproliferative syndrome. J Eur Acad Dermatol Venereol 2008;22:110-2.

Guenova E, Hoetzenecker W, Metzler G, Röcken M, Schaller M.Multicentric Bowen disease in linear porokeratosis. Eur J Dermatol 2007;17:439-40.

Voykov B, Guenova E, Süsskind D, Schiefer U. [Tuberous sclerosis: aninterdisciplinary diagnosis]. Klin Monbl Augenheilkd 2007; 224:441-4.

Guenova E, Schaller M. Residents' corner July 2012. (Carpe)DIEM--Dermatological Indications for Electron Microscopy: cerebral autosomaldominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL). Eur J Dermatol 22:586-7.

Guenova E, Schaller M. Residents' corner September 2012. (Carpe)DIEM.Dermatological indications for electron microscopy: argyria. Eur JDermatol 22:718.

Guenova E, Schaller M. (Carpe)DIEM - dermatological indications forelectron microscopy: Amyloid deposition. [corrected]. Eur J Dermatol22:161.

11

publications

title

journalpaper/review

Hoetzenecker W, Guenova E, Mitev V, Schanz S, Ulmer A, Fierlbeck G.Treatment of pyoderma gangrenosum with topical factor XIII. Eur JDermatol 23:653-7.

Guenova E, Schaller M. Residents' corner March 2012. (Carpe)DIEM--dermatological indications for electron microscopy: orf infection. Eur JDermatol 22:293.

Guenova E, Eberle F C, Metzler G, Schaller M. Residents’ cornerNovember 2012. CarpeDIEM--Dermatological indications for electronmicroscopy: disseminated epidermolytic acanthomas. Eur J Dermatol22:822-3.

Guenova E, Schaller M. Residents' corner May 2012. (Carpe)DIEM -dermatological indications for electron microscopy: Herpesvirus infection.Eur J Dermatol 22:440.

Torres T, Guenova E, Feldmeyer L, Nosbaum A. Residents' cornerNovember 2011. Residents' editorial choice. Eur J Dermatol 21:1029.

Feldmeyer L, Guenova E, Torres T, Nosbaum A. Residents'corner May2011. Eur J Dermatol 21:461-2.

Feldmeyer L, Guenova E, Torres T, Nosbaum A. Residents' corner March2011. Eur J Dermatol 21:304-6.

Hoetzenecker W, Guenova E, Böttinger T U, Häfner H M, Breuninger H.Mapping of specific sentinel node locations for skin cancer of the head.Eur J Dermatol 21:354-8.

Feldmeyer L, Guenova E, Torres T, Nosbaum A. Residents' cornerSeptember 2011. Residents' editorial choice. Eur J Dermatol 21:826-7.

12

publications

title

journalpaper/review

Guenova E, Schaller M. Residents' corner September 2011. (Carpe)DIEM- Birbeck granule in Langerhans cell histiocytosis. Eur J Dermatol 21:827.

Guenova E, Schaller M. Residents' corner November 2011. (Carpe)DIEM -dermatological indications for electron microscopy: Ehlers Danlossyndrome. Eur J Dermatol 21:1030.