Embed Size (px)
Citation preview
Ludwike van Kalmthout arts-onderzoeker
lsquoWeek van de Urologiersquo
St Antonius Ziekenhuis 28 september 2017
PEPPER-studie PSMA-PETCT in Primary staging of Prostate CancER
Anatomie het mannelijk bekken
Dhr H 63 jaar
bull Door huisarts verwezen naar uroloog
bull PSA 549 ngml
bull Rectaal toucher verharde rechter prostaathelft
bull Echo prostaat tumor in beide
prostaatkwabben met
ingroei in zaadblaasjes
bull Prostaatbiopten Gleason Score 9
Conclusie Hoog-risico prostaatkanker
Aanvullend Onderzoek
bull 1 Uitzaaiingen in de lymfeklieren
CTMRI Lymfeklierdissectie
bull 2 Uitzaaiingen in de botten
Botscan
Lymfeklierdissectie
Lymfeklierdissectie
1 Botuitzaaiingen 2 Dhr H Botuitzaaiingen
Gallium-68 PSMA-PETCT
Veelbelovende nieuwe scan
Brengt zowel uitzaaiingen in lymfeklieren als botten in beeld
PETCT combinatie van moleculaire en anatomische informatie PSMA Prostaat Specifiek Membraan Antigeen Gallium-68 PSMA Radioactief gelabelde stof
Procedure - Infuus met Gallium-68 PSMA - Scannen 60 minuten
PET Fusie PET en CT CT
Dhr H Gallium-68 PSMA PETCT
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
Anatomie het mannelijk bekken
Dhr H 63 jaar
bull Door huisarts verwezen naar uroloog
bull PSA 549 ngml
bull Rectaal toucher verharde rechter prostaathelft
bull Echo prostaat tumor in beide
prostaatkwabben met
ingroei in zaadblaasjes
bull Prostaatbiopten Gleason Score 9
Conclusie Hoog-risico prostaatkanker
Aanvullend Onderzoek
bull 1 Uitzaaiingen in de lymfeklieren
CTMRI Lymfeklierdissectie
bull 2 Uitzaaiingen in de botten
Botscan
Lymfeklierdissectie
Lymfeklierdissectie
1 Botuitzaaiingen 2 Dhr H Botuitzaaiingen
Gallium-68 PSMA-PETCT
Veelbelovende nieuwe scan
Brengt zowel uitzaaiingen in lymfeklieren als botten in beeld
PETCT combinatie van moleculaire en anatomische informatie PSMA Prostaat Specifiek Membraan Antigeen Gallium-68 PSMA Radioactief gelabelde stof
Procedure - Infuus met Gallium-68 PSMA - Scannen 60 minuten
PET Fusie PET en CT CT
Dhr H Gallium-68 PSMA PETCT
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
Dhr H 63 jaar
bull Door huisarts verwezen naar uroloog
bull PSA 549 ngml
bull Rectaal toucher verharde rechter prostaathelft
bull Echo prostaat tumor in beide
prostaatkwabben met
ingroei in zaadblaasjes
bull Prostaatbiopten Gleason Score 9
Conclusie Hoog-risico prostaatkanker
Aanvullend Onderzoek
bull 1 Uitzaaiingen in de lymfeklieren
CTMRI Lymfeklierdissectie
bull 2 Uitzaaiingen in de botten
Botscan
Lymfeklierdissectie
Lymfeklierdissectie
1 Botuitzaaiingen 2 Dhr H Botuitzaaiingen
Gallium-68 PSMA-PETCT
Veelbelovende nieuwe scan
Brengt zowel uitzaaiingen in lymfeklieren als botten in beeld
PETCT combinatie van moleculaire en anatomische informatie PSMA Prostaat Specifiek Membraan Antigeen Gallium-68 PSMA Radioactief gelabelde stof
Procedure - Infuus met Gallium-68 PSMA - Scannen 60 minuten
PET Fusie PET en CT CT
Dhr H Gallium-68 PSMA PETCT
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
Aanvullend Onderzoek
bull 1 Uitzaaiingen in de lymfeklieren
CTMRI Lymfeklierdissectie
bull 2 Uitzaaiingen in de botten
Botscan
Lymfeklierdissectie
Lymfeklierdissectie
1 Botuitzaaiingen 2 Dhr H Botuitzaaiingen
Gallium-68 PSMA-PETCT
Veelbelovende nieuwe scan
Brengt zowel uitzaaiingen in lymfeklieren als botten in beeld
PETCT combinatie van moleculaire en anatomische informatie PSMA Prostaat Specifiek Membraan Antigeen Gallium-68 PSMA Radioactief gelabelde stof
Procedure - Infuus met Gallium-68 PSMA - Scannen 60 minuten
PET Fusie PET en CT CT
Dhr H Gallium-68 PSMA PETCT
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
Lymfeklierdissectie
Lymfeklierdissectie
1 Botuitzaaiingen 2 Dhr H Botuitzaaiingen
Gallium-68 PSMA-PETCT
Veelbelovende nieuwe scan
Brengt zowel uitzaaiingen in lymfeklieren als botten in beeld
PETCT combinatie van moleculaire en anatomische informatie PSMA Prostaat Specifiek Membraan Antigeen Gallium-68 PSMA Radioactief gelabelde stof
Procedure - Infuus met Gallium-68 PSMA - Scannen 60 minuten
PET Fusie PET en CT CT
Dhr H Gallium-68 PSMA PETCT
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
Lymfeklierdissectie
1 Botuitzaaiingen 2 Dhr H Botuitzaaiingen
Gallium-68 PSMA-PETCT
Veelbelovende nieuwe scan
Brengt zowel uitzaaiingen in lymfeklieren als botten in beeld
PETCT combinatie van moleculaire en anatomische informatie PSMA Prostaat Specifiek Membraan Antigeen Gallium-68 PSMA Radioactief gelabelde stof
Procedure - Infuus met Gallium-68 PSMA - Scannen 60 minuten
PET Fusie PET en CT CT
Dhr H Gallium-68 PSMA PETCT
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
1 Botuitzaaiingen 2 Dhr H Botuitzaaiingen
Gallium-68 PSMA-PETCT
Veelbelovende nieuwe scan
Brengt zowel uitzaaiingen in lymfeklieren als botten in beeld
PETCT combinatie van moleculaire en anatomische informatie PSMA Prostaat Specifiek Membraan Antigeen Gallium-68 PSMA Radioactief gelabelde stof
Procedure - Infuus met Gallium-68 PSMA - Scannen 60 minuten
PET Fusie PET en CT CT
Dhr H Gallium-68 PSMA PETCT
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
Gallium-68 PSMA-PETCT
Veelbelovende nieuwe scan
Brengt zowel uitzaaiingen in lymfeklieren als botten in beeld
PETCT combinatie van moleculaire en anatomische informatie PSMA Prostaat Specifiek Membraan Antigeen Gallium-68 PSMA Radioactief gelabelde stof
Procedure - Infuus met Gallium-68 PSMA - Scannen 60 minuten
PET Fusie PET en CT CT
Dhr H Gallium-68 PSMA PETCT
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
Procedure - Infuus met Gallium-68 PSMA - Scannen 60 minuten
PET Fusie PET en CT CT
Dhr H Gallium-68 PSMA PETCT
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
PET Fusie PET en CT CT
Dhr H Gallium-68 PSMA PETCT
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
Dhr H Gallium-68 PSMA-PETCT
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
PEPPER-studie Waarom
bull 20 van de hoog-risico patieumlnten met lsquoschonersquo
botscan heeft wegravel afwijkingen op de Gallium-68 PSMA PETCT
Zinloze lymfeklierdissectie
bull In regio Utrecht wordt de Gallium-68 PSMA PETCT al ingezet als
reguliere scan
bull Maar nog weinig bekend over de precieze nauwkeurigheid
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
PEPPER-studie Kernpunten bull Onderzoeksvraag Hoe nauwkeurig is de Gallium-68 PSMA PETCT in het aantonen
van uitzaaiingen van prostaatkanker
bull Details
100 patienten Zowel PSMA PETCT als een lymfeklieroperatie Vergelijking afwijkingen op scan met het uitgenomen weefsel Start volgende week
bull Multicenter
St Antonius Ziekenhuis Nieuwegein-Utrecht UMC Utrecht Meander Medisch Centrum Amersfoort hellip
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
Vragen
bull Uroloog
Harm van Melick
hvanmelickantoniusziekenhuisnl
bull Arts-Onderzoeker
Ludwike van Kalmthout
LWMvanKalmthout-2umcutrechtnl
bull Nucleair Geneeskundige
Jules Lavalaye
jlavalayeantoniusziekenhuisnl
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
Referenties bull Budaus L Leyh-Bannurah S-R Salomon G Michl U Heinzer H Huland H et al Initial Experience of
(68)Ga-PSMA PETCT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy Eur
Urol Switzerland 2016 Mar69(3)393ndash6
bull Maurer T Gschwend JE Rauscher I Souvatzoglou M Haller B Weirich G et al Diagnostic Efficacy of
(68)Gallium-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of of 130 consecutive
Patients with Intermediate to High-Risk Prostate Cancer J Urol [Internet] 2015 Dec 9
bull Herlemann A Wenter V Kretschmer A Thierfelder KM Bartenstein P Faber C et al (68)Ga-PSMA
Positron Emission TomographyComputed Tomography Provides Accurate Staging of Lymph Node
Regions Prior to Lymph Node Dissection in Patients with Prostate Cancer Eur Urol [Internet] 2016 Jan
19
bull van Leeuwen PJ Emmett L Ho B Delprado W Ting F Nguyen Q et al Prospective Evaluation of
68Gallium-PSMA Positron Emission TomographyComputerized Tomography for Preoperative Lymph
Node Staging in Prostate Cancer BJU Int [Internet] 2016 May 21
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
bull Perera M1 Papa N1 Christidis D1 Wetherell D1 Hofman MS2 Murphy DG3 Bolton D4 Lawrentschuk
N5 Sensitivity Specificity and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen
Positron Emission Tomography in Advanced Prostate Cancer A Systematic Review and Meta-analysis
Eur Urol 2016 Jun 27
bull Afshar-Oromieh A1 Avtzi E Giesel FL Holland-Letz T Linhart HG Eder M Eisenhut M Boxler S
Hadaschik BA Kratochwil C Weichert W Kopka K Debus J Haberkorn U The diagnostic value of PETCT
imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Eur J Nucl Med Mol Imaging 2015 Feb42(2)197-209 doi 101007s00259-014-2949-6 Epub 2014 Nov
20
bull Morigi JJ1 Stricker PD2 van Leeuwen PJ2 Tang R3 Ho B4 Nguyen Q2 Hruby G5 Fogarty G6 Jagavkar
R6 Kneebone A5 Hickey A4 Fanti S7 Tarlinton L4 Emmett L3 Prospective Comparison of 18F-
Fluoromethylcholine Versus 68Ga-PSMA PETCT in Prostate Cancer Patients Who Have Rising PSA After
Curative Treatment and Are Being Considered for Targeted Therapy J Nucl Med 2015 Aug56(8)1185-
90 doi 102967jnumed115160382 Epub 2015 Jun 25
bull Joniau S Van den Bergh L Lerut E Deroose CM Haustermans K Oyen R Budiharto T Ameye F
Bogaerts K Van Poppel H Mapping of pelvic lymph node metastases in prostate cancer Eur Urol 2013
Mar63(3)450-8 doi 101016jeururo201206057 Epub 2012 Jul 6
15
![PET/ CT [Positron Emission Tomography]](https://img.pdfslide.tips/doc/110x75/56d6bf451a28ab30169592f3/pet-ct-positron-emission-tomography.jpg)
