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7/23/2019 Perfil Lipoproteico
http://slidepdf.com/reader/full/perfil-lipoproteico 1/41
UNIVERSIDADE FEDERAL DE PERNAMBCO
CENTRO DE CIÊNCIAS BIOLÓGICAS
CURSO DE BIOMEDICINA
AÍLA LIMA DE MELO
PERFIL LIPOPROTÉICO DA POPULAÇÃO RESIDENTE NA
MATA NORTE DO ESTADO DE PERNAMBUCO
RECIFE
2013
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AÍLA LIMA DE MELO
PERFIL LIPOPROTÉICO DA POPULAÇÃO RESIDENTE NA
MATA NORTE DO ESTADO DE PERNAMBUCO
Trabalh !" C#$l%&' !" $%r&a(r"&"#)a! a C%r& !" Gra!%a*' "+B,+"!,$,#a !a U#,-"r&,!a!" F"!"ral !"P"r#a+b%$ .UFPE/ C"#)r !" C,#$,a&B,l,$a& $+ r"%,&,) (ar$,al (arab)"#*' ! ra% !" Ba$har"l "+B,+"!,$,#a4
Orientação5 M&$4 Mar"6 7"#r8%"F"rr",ra E6"r)
Coorientação5 Carl& 7"#r,%" F%l#$,
P"r",ra Val"
RECIFE
2013
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AÍLA LIMA DE MELO
PERFIL LIPOPROTÉICO DA POPULAÇÃO RESIDENTE NA
MATA NORTE DO ESTADO DE PERNAMBUCO
M#ra9,a a(r-a!a "+ :::: ; :::: ; ::::
BANCA E<AMINADORA
:::::::::::::::::::::::::::::::::::::::::::
M&$4 Mar"6 7"#r8%" F"rr",ra E6"r) .Or,"#)a!r/Labra)r, !" I+%#(a)l,a !" =",> A&a+, .LI=A/
:::::::::::::::::::::::::::::::::::::::::::
M&$4 ?' L%,> @%,r,# !a S,l-a F,lh .M"+br/Labra)r, !" I+%#(a)l,a !" =",> A&a+, .LI=A/
:::::::::::::::::::::::::::::::::::::::::::
M&$4 Na)al,a C8b"ll" L,+a Ol,-",ra .M"+br/Labra)r, !" I+%#(a)l,a !" =",> A&a+, .LI=A/
:::::::::::::::::::::::::::::::::::::::::::
M&$4 Rb"r)a L%$,a#a ! Na&$,+"#) G!#" .M"+br/Labra)r, !" I+%#(a)l,a !" =",> A&a+, .LI=A/
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D"%& +,#ha 9r*a " r"9,4 A& +"%& (a,&A!a+& " D"#,&" " ,r+'& Al,#" " L%$,a#a ("la+r " !"!,$a*'4
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AGRADECIMENTOS
Ara!"* (r,+",ra+"#)" a D"%& (r %,ar +"%& (a&&& a) a%, +" &%&)"#)ar " $#$"!"r
9r*a& (ara $a+,#ha!a4 Pr ,l%+,#ar +"%& ("#&a+"#)& " +" a%!ar a !"rr%bar $a!a b&)$%l! $a+,#h
Ara!"* a& +"%& (a,& A!a+& " D"#,&" +"%& +a,r"& ""+(l&4 Obr,a!a (r $a!a,#$"#),- " r,"#)a*' ("la& ra*H"& "+ +"% 9a-r ("la (r"$%(a*' (ara %" "&),-"&&"&"+(r" a#!a#! ("l $a+,#h $rr")4 A& +,#ha& ,r+'& Al,#" " L%$,a#a (r )!a& a&!,&$%&&H"& $#&)r%),-a& (r )! a+r " $ar,#h %a#! (r"$,&",4 A& +"%& ),& ),a& a-&a-& (r,+& " (r,+a& %" &"+(r" "&),-"ra+ (r"&"#)"& a,#!a %" J !,&)K#$,a4 A +"%#a+ra! D, (r )! a+r $ar,#h (a$,#$,a " $+(r""#&' %" )"+ +" !"!,$a!
A +"% a+, " r,"#)a!r Mar"6 7"#r8%" F"rr",ra E6"r) %" $+ +%,)a (a$,#$,a "
a)"#*' !"!,$% ! &"% -al,& )"+( (ara +" %,ar "+ $a!a (a&& !"&)" )rabalh4 A& (r9"&&r"& Mar$& A#!r ?"l+a S%>a Da#8"ll8 Br%#"&6a " ?& L%,> ("la $#)r,b%,*'#a +,#ha -,!a a$a!+,$a " (r )a#)a ,#9l%#$,a #a +,#ha 9%)%ra -,!a (r9,&&,#al4 A A#!rGal-' ("la a%!a #& $l$%l& "&)a)&),$& !"&&" )rabalh
A& +"%& $l"a& !" $la&&" " a+,& (ara a -,!a ,#)",ra5 A#a =arl,#a Brbara M#)",rCa+,la Sa#)& C"l& Barb&a Clar,&&a A)a!" Clar,&&a R,b",r D," Mar),#& ?%a# L%,>7"rb"r) a+%r, Na)hal8a Ol,-",ra " Tal,)a Ara $%a& a+,>a!"& "+ al%+ ++"#) !"+,#ha -,!a +" 9,>"ra+ $r"&$"r $+ "&)%!a#)" " $+ ("&&a4 P"l& ++"#)& !" 9"l,$,!a!"
("r"#" %" $#-,-"+& " ("l& ++"#)& !" !,-"r&'
A )!& ! r%( Pr&("$+l " "%,(" !" 7"+a)l,a Labra)r,al ("l ,+"#& a(,$#$"!,! #"&)a r#a!a ("l $r"&$,+"#) $,"#)9,$ " ("&&al4 Ara!"* a )!& (r "&&")"+( %" (a&&a+& %#)& ("l& ,#+"r& ++"#)& !" al"r,a $+(a#h",r,&+ #!" a9"l,$,!a!" " %#,' &"+(r" "&),-"ra+ ,#)"ra!a&
A )!& %" +"&+ #' "&)a#! $,)a!& a%, )a#) $#)r,b%ra+ (ara a $#$l%&' !"&)a")a(a ara!"* ,+"#&a+"#)"4
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N' &ab"#! %" "ra ,+(&&-"l 9, l " 9">
?"a# C$)"a%
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MELO Ala L,+a P"r9,l l,((r),$ !a ((%la*' r"&,!"#)" #a Ma)a Nr)" ! "&)a! !"P"r#a+b%$4 20134 M#ra9,a .C%r& !" B,+"!,$,#a/ U#,-"r&,!a!" F"!"ral !"P"r#a+b%$ R"$,9" 20134
RESUMO
A& !,&l,(,!"+,a& &' "l"-a*H"& &r,$a& !" %+ % +a,& $+(#"#)"& &a#%#"&
!"$rr"#)"& !" !,&)rb,& "+ %al%"r 9a&" ! +")abl,&+ l,(!,$4 E&)" "$"&& (!" l"-ar
a a$+%l ,#)ra$"l%lar !" l,(!"& " !"(&,*' !& +"&+& "+ -a&& " )"$,!& "ra#!
a%+"#) ! r,&$ $ar!,-a&$%lar4 A (r"&"#)" +#ra9,a )"-" $+ b"),- !")"r+,#ar
("r9,l l,((r),$ "+ +ra!r"& !a Ma)a Nr)" ! "&)a! !" P"r#a+b%$4 E&)" "&)%! 9,
r"al,>a! $+ Q1 (a$,"#)"& $+ ,!a!" "#)r" 0 " a#&4 O& (r$"&&& a#al),$& 9ra+r"al,>a!& # Labra)r, !" A#l,&"& Cl#,$a& @UALI LAB .T,+baba PE/4 Fra+
$l")a!a& a+&)ra& !" &a#%" . +L/ "+ )%b& Vacutainer " &r 9, &"(ara! !a& h"+$,a&
(r $"#)r,9%a*' (ara a !&a"+ !" 7DL$4 A !")"r+,#a*' !" LDL$ 9, b),!a ("l
$l$%l !" Fr,"!"al!4 A +"!,a#a !" ,!a!" #a ((%la*' 9, !" Q a#&4 C#&,!"ra#! $+
!,&l,(,!+,$ (a$,"#)" $+ al)"ra*' "+ ("l +"#& %+a !a& 9ra*H"& ! ("r9,l l,((r)",$
a(r,+a!a+"#)" a +")a!" !& (ar),$,(a#)"& .0/ "#%a!r%&" $+ (r)a!r"& !"&&a
(a)l,a4 A 9ra*' 7DL$ b&"r-%&" al)"ra!a "+ 33 (a$,"#)"& !,9"r"#)"+"#)" !a LDL$%" "&)"-" al)"ra!a "+ a("#a& 1Q (a$,"#)"&4 A& $#$"#)ra*H"& !a& l,((r)"#a& (ra),$a+"#)"
#' !,9"r,ra+ "+ r"la*' a &" (ara (arK+")r 7DL$4 E+ r"la*' a LDL$ ,#!,-!%&
! &" 9"+,#,# a(r"&"#)ara+ -alr"& +a,& "l"-a!& .±DP W Q3/4 E#)r" & h+"#&
-alr +,+ "#$#)ra! !" LDL$ 9, !" 1XY +;!L "#%a#) %" #a& +%lh"r"& 9, !"
23Y +;!L4 A& !"#*a& $ar!,-a&$%lar"& r"(r"&"#)a+ %+ ra#!" (rbl"+a !" &a!" (bl,$a
# Bra&,l #"ra#! $%&)& # a)"#!,+"#) " #a& ba,a& h&(,)alar"&4 D"-"&" (r)a#)
,#)"#&,9,$ar "&9r*& #a !")"$*' (r"$$" (r"-"#*' " #a "!%$a*' "+ &a!" (ara +,#,+,>ar "&&"& ara-& %" )a#) $a%&a+ (r"%>& J %al,!a!" !" -,!a !a ((%la*'4
Paa!ra"#$%a!e& D,&l,(,!"+,a ("r9,l l,((r)",$ 7DL$ LDL$4
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MELO Ala L,+a L,((r)",# (r9,l" ,# ((%la),# 9 Ma)a Nr)" r",# 9 P"r#a+b%$420134 M#ra(h .B,+"!,$,#" C%r&"/ F"!"ral U#,-"r&,)8 9 P"r#a+b%$ R"$,9" 2013
ABSTRACT
D8&l,(,!"+,a ,& ,#$r"a&"! &"r%+ 9 #" r +r" bl! $+(#"#)& r"&%l),# 9r+ a#8 (ha&"
!,&)%rba#$"& ,# l,(,! +")abl,&+4 Th,& "$"&& $a# l"a! ) a$$%+%la),# 9 ,#)ra$"ll%lar l,(,!&
a#! !"(&,),# ,# )h" &a+" -"&&"l& a#! ),&&%"& "#"ra),# ,#$r"a&"! $ar!,-a&$%lar r,&6 4 Th,&
+#ra(h a,+& ) !")"r+,#" )h" l,((r)",# (r9,l" ,# r"&,!"#)& ,# Ma)a Nr)" r",#
l$a)"! a) &)a)" 9 P"r#a+b%$4 Th,& &)%!8 a& $#!%$)"! ,)h Q1 (a),"#)& a"! b")""# 0
a#! 8"ar&4 Th" a#al8),$al (r$"!%r"& "r" ("r9r+"! ,# )h" Cl,#,$al Labra)r8
@UALILAB .T,+baba PE/4 Bl! &a+(l"& . +L/ "r" $ll"$)"! ,# Va$%)a,#"r )%b"& a#!
&"r%+ a& &"(ara)"! 9r+ bl! $"ll& b8 $"#)r,9%a),# 9r )h" +"a&%r"+"#) 9 7DL$4 Th"
!")"r+,#a),# 9 LDL $ a& b)a,#"! b8 )h" Fr,"!"al! "%a),#4 Th" +"!,a# a" 9 )h"
((%la),# a& Q 8"ar&4 C#&,!"r,# h !8&l,(,!"+,$ (a),"#)& ,)h al)"ra),#& ,# a) l"a&)
#" 9 )h" 9ra$),#& 9 )h" l,((r)",# (r9,l" a((r,+a)"l8 hal9 9 )h" (ar),$,(a#)& .40/
9ra+"! a& (a),"#)& ,)h )h,& (a)hl84 Th" 7DL$ a& $ha#"! ,# 33 (a),"#)& %#l,6" LDL$h,$h a& ab#r+al ,# 1Q (a),"#)&4 Th" $#$"#)ra),#& 9 l,((r)",#& har!l8 !,99"r r"ar!,#
&" 9r 7DL$ (ara+")"r4 I# r"la),# ) LDL$ 9"+al"& &h"! h,h"r -al%"& .ZSD W Q43/4
A+# +"# )h" +a,+%+ -al%" 9%#! ,# LDL$ a& 1X4Y + ; !L h"r"a& ,# +"# a&
234Y +;!L4 Car!,-a&$%lar !,&"a&"& ar" a +ar (%bl,$ h"al)h (rbl"+ ,# Bra>,l b%r!"#,#
$&)& ,# $ar" a#! ,# h&(,)al a!+,&&,#&4 Sh%l! )h"r"9r" ,#)"#&,98 "99r)& ,# )h" "arl8
!")"$),# (r"-"#),# a#! h"al)h "!%$a),# ) +,#,+,>" )h"&" !,&"a&"& )ha) $a%&" +%$h
!a+a" ) )h" %al,)8 9 l,9"4
'e(#)or*"& D8&l,(,!"+,a l,((r)",# (r9,l" 7DL$ LDL$4
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LISTA DE FIGURAS
Fi+,ra -& E&%"+a "+ $r)" !" %+a l,((r)"#a44444444444444444444444444444444444444444444444444444444444444444441X
Fi+,ra .a& M")abl,&+ !a& L,((r)"#a&5 C,$l& ""# "#!"# " )ra#&(r)"
r"-"r&44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444 1Q
Fi+,ra ./& M")abl,&+ h"(),$ !a& l,((r)"#a&44444444444444444444444444444444444444444444444444444444444444441Q
Fi+,ra 0& Pr$"&& !" 9r+a*' !a (la$a a)"r&$l"r),$a4444444444444444444444444444444444444444444444444444444422
viii
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LISTA DE TABELAS E GR1FICOS
Ta/ea -& Valr"& !" r"9"r#$,a !& l,(!"& (ara ,#!,-!%& a$,+a !& 20 a#& !" ,!a!"444442
Ta/ea .& D,&)r,b%,*' !a a+&)ra !& r"&,!"#)"& !a Ma)a Nr)" ! "&)a! !"
P"r#a+b%$44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442X
Ta/ea 0& N-",& !" 7DL$ " LDL$ &"%#! &" #& r"&,!"#)"& !a Ma)a Nr)" ! "&)a!!" P"r#a+b%$444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442
Gr23i$o -& P"r9,l l,((r)",$ #& r"&,!"#)"& !a Ma)a Nr)" ! "&)a! !" P"r#a+b%$
&"%#! & -alr"& r"$+"#!a!& ("la III D,r")r,>"& Bra&,l",ra& &br"
!,&l,(,!"+,a&44 444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444
4444444444444444444442
Gr23i$o .& R"la*' "#)r" $#$"#)ra*' !" 7DL$ " ,!a!" #& r"&,!"#)"& !a Ma)a Nr)" !
"&)a! !" P"r#a+b%$4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442Q
Gr23i$o 0& R"la*' "#)r" $#$"#)ra*' !" LDL$ " ,!a!" #& r"&,!"#)"& !a Ma)a Nr)" !
"&)a! !" P"r#a+b%$4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442Q
ix
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LISTA DE ABRE4IATURAS E SIGLAS
IAM I#9ar) A%! ! M,$r!,
TG Tr,l,$"r!"
VLDL$ L,((r)"#a !" +%,)a ba,a !"#&,!a!"
LDL$ L,((r)"#a !" ba,a !"#&,!a!"
7DL$ L,((r)"#a !" al)a !"#&,!a!"
DCV D"#*a Car!,-a&$%lar
IMIP I#&),)%) !" M"!,$,#a I#)"ral Pr94 F"r#a#! F,%",ra
SUS S,&)"+a [#,$ !" Sa!"
N7ANES Na),#al 7"al)h a#! N%)r,),# Ea+,#a),# S%r-"8
x
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SUM1RIO
LISTA DE FIGURAS444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444-,,,LISTA DE TABELAS E GR1FICOS444444444444444444444444444444444444444444444444444444444444444444444444444444444444,
LISTA DE ABRE4IATURAS E SIGLAS444444444444444444444444444444444444444444444444444444444444444444444444444444
-5 INTRODUÇÃO44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441.5 RE4ISÃO BIBLIOGR1FICA4444444444444444444444444444444444444444444444444444444444444444444444444444444444444441Y
2414 P"r9,l l,(!,$444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441Y2424 @%,l+$r#&444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441X2434 VLDL$l"&)"rl444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441X244 LDL$l"&)"rl444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441
244 7DL$l"&)"rl444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444441Q24Y4 Tr,l,$"r!"&44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442024X4 D,&l,(,!"+,a&4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444421244 A)"r&$l"r&"4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444421
05 OB6TI4OS44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444233414 Ob"),- "ral4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444233424 Ob"),-& "&("$9,$&4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444423
75 METODOLOGIA4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442414 A+&)ra"+4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442424 Cr,)r,& !" ,#$l%&'4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442434 Cr,)r,& !" "$l%&'444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442
44 Cl")a !" !a!&4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444244 A#l,&" labra)r,al444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444424Y4 A#l,&" !" !a!&4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442Y
85 RESULTADOS44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444442X95 DISCUSSÃO44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444430:5 CONCLUS;ES444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444433<5 REFER=NCIAS4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444443>5 ANE?OS4444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444443Q
Q414 Car)a !" a#%#$,a44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444444443QQ424 A(r-a*' C+,) !" \),$a44444444444444444444444444444444444444444444444444444444444444444444444444444444444444444440
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MELO, A. L. Perfl lipoprotéico da população...
-5 INTRODUÇÃO
A& r!%ra& # $a& !& a#,+a,& " & l"& #& -"")a,& &' a& r"&"r-a& "#"r),$a&
+a,& ,+(r)a#)"& (ara ra#,&+ .MANSO 1QY/4 Para al+ !a 9%#*' !" r"&"r-a
"#"r),$a & l,(!"& )+ 9%#*H"& "&)r%)%ra,& %" %a#! a&&$,a!a& a %)ra& +l$%la&
rK#,$a& $%+(r"+ 9%#*H"& "&("$9,$a& .7ALPERN 1QQX/4 A& l,((r)"#a& (la&+),$a& &'
(ar)$%la& $+(l"a& +a$r+l"$%lar"& $#&),)%!a& (r +l$%la& (r),$a& " l,(!,$a& "
!,-,!"+&" "+ $la&&"&5 %,l+$r#& VLDL LDL 7DL .NAITO 2003 NELSON ") al4
2003/4 A 9%#*' (r,#$,(al !a& l,((r)"#a& (la&+),$a& (ar"$" &"r )ra#&(r)" !&
)r,l,$"r!"& " ! $l"&)"rl !& l$a,& !" r,"+ ] # ,#)"&),# .r,"+ ""#a/ " #
9a! .r,"+ "#!"#a/ ] (ara & l$a,& !" ar+a>"#a+"#) " %),l,>a*' .SC7IAVO ") al42003/4
A l# !& a#& )"+&" b&"r-a! %+a $r"&$"#)" (r"$%(a*' $+ ("r9,l l,(!,$
" &%a& ,+(l,$a*H"& #a& !"#*a& $ar!,-a&$%lar"&4 D"&,#a+&" !,&l,(,!"+,a& %
h,("rl,(,!"+,a& a& "l"-a*H"& &r,$a& !" %+ % +a,& $+(#"#)"& &a#%#"& !"$rr"#)"& !"
!,&)rb,& "+ %al%"r 9a&" ! +")abl,&+ l,(!,$ .C7ACRA ") al4 200/4 E&)" "$"&&
(!" l"-ar a a$+%l ,#)ra$"l%lar !" l,(!"& " !"(&,*' !& +"&+& "+ -a&& " )"$,!&
"ra#! a%+"#) ! r,&$ $ar!,-a&$%lar % a) +"&+ (a)l,a& )a,& $+5 a)"r&$l"r&",#9ar) a%! ! +,$r!, .IAM/ "&)"a)&" h"(),$a b"&,!a!" D,ab")"& M"ll,)%& T,( II
"#)r" %)ra& .FIL7O 2000/4
A a)"r&$l"r&" %+ (r$"&& +%l),9a)r,al (rr"&&,- " l"#) # %al h al)"ra*'
#a (ar"!" ar)"r,al .GOTTLIEB ") al4 200/4 A #"&" !a 9r+a*' !a (la$a !" a)"r+a
b,l,$a $+(l"a #!" h %+ $r"&$,+"#) (rr"&&,- !" l,((r)"#a #a $a+a!a ,#)ra "
")ra$"l%lar a&&$,a! a %+ (r$"&& $"l%lar (rl,9"ra),- $a&,#a#! !"(&,) !" )r+b
.LAURINDO 2000/4 S"%#! a& III D,r")r,>"& !a S$,"!a!" Bra&,l",ra !" Car!,l,a
.2001/ a !"#*a a)"r&$l"r),$a a (r,#$,(al $a%&a !" +r)" # Bra&,l4
D"&!" a !$a!a !" 0 ! &$%l (a&&a! !"&"#-l-"ra+&" ,#+"ra& b&"r-a*H"&
$l#,$a& "&)%!& ra#!+,>a!& $+ ra#!" a+&)ra"+ %" ("r+,),ra+ !")"r+,#ar $+
&"%ra#*a & 9a)r"& !" r,&$ +!,9,$-",& !"&)a& !"#*a& .BALTALI ") al4 2003/ "#)r" "l"&
"#$#)ra+&" )aba,&+ al$l,&+ &"!"#)ar,&+ " & hb,)& al,+"#)ar"&4
A("&ar !a al)a +r)al,!a!" (r !"#*a& $ar!,-a&$%lar"& # Bra&,l %a&" #' h !a!&
&br" #-"l !" l,((r)"#a& "+ ((%la*' $+ ,!a!" a-a#*a!a4
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MELO, A. L. Perfl lipoprotéico da população...
N"&&" &"#),! (r"&"#)" )rabalh b"),-a !")"r+,#ar ("r9,l l,((r),$ "
,!"#),9,$ar (&&-",& !,&l,(,!"+,a& %#) a& r"&,!"#)"& #a r",' !a Ma)a Nr)" ! "&)a! !"
P"r#a+b%$4
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MELO, A. L. Perfl lipoprotéico da população...
.5 RE4ISÃO BIBLIOGR1FICA
.5- PERFIL LIP@DICO
O& l,(!"& !"9,#"+ %+ $#%#) !" &%b&)K#$,a& %+,$a& %" a $#)rr, !a& %)ra&
$la&&"& !" $+(&)& rK#,$& #' &' $ara$)"r,>a!a& (r al%+ r%( 9%#$,#al $+%+ "
&,+ ("la &%a al)a &l%b,l,!a!" "+ &l-"#)"& rK#,$& " ,#&l%b,l,!a!" "+ %a4 O& l,(!"&
+a,& ,+(r)a#)"& ! (#) !" -,&)a 9,&,l,$ " $l#,$ &' & $,!& ra& &
)r,l,$"r!"& .TG/ & 9&9l,(!"& " $l"&)"rl4 O& $,!& ra& (!"+ &"r5 &a)%ra!&
+# % (l,,#&a)%ra!& &"#! & l),+& (r"$%r&r"& !" b,+l$%la& ,+(r)a#)"& $+ a&
(r&)ala#!,#a& " $+ ,#+"ra& 9%#*H"& &br" $#)ra),l,!a!" ! +&$%l l,& " +!%la*' !"
r"$"(*' !" &,#al hr+#al4 O& TG &' a 9r+a !" ar+a>"#a+"#) "#"r),$ +a,&
,+(r)a#)" # ra#,&+ "#%a#) & 9&9l,(!"& 9r+a+ a b,$a+a!a l,(!,$a "&)r%)%ra
b&,$a !a& +"+bra#a& $"l%lar"& " $l"&)"rl (r"$%r&r !&5 hr+#,& "&)"r,!"& !&
$,!& b,l,ar"& " !a -,)a+,#a D al+ !" )"r ,+(r)a#)"& 9%#*H"& #a& +"+bra#a& $"l%lar"&
,#9l%"#$,a#! a &%a 9l%,!"> " "&)a! !" a),-a*' !" "#>,+a& .C7AMPE ") al 200X/4
D"-,! J #a)%r">a h,!r9b,$a !& l,(!"& &"% +"$a#,&+ !" )ra#&(r)" "
!,&)r,b%,*' # (la&+a #' &"r,a (&&-"l &"+ al%+a 9r+a !" a!a()a*' h,!r9l,$a4 A&&,+
a& l,((r)"#a& .FIGURA 1/ &' r"&(#&-",& ("l )ra#&(r)" !" l,(!"& # &a#%"
"&("$,al+"#)" $l"&)"rl " TG $% +")abl,&+ "&) ,#),+a+"#)" r"la$,#a! $+ a
,#,$,a*' " (rr"&&' !a a)"r&$l"r&" .FRANSSEN ") al4 200 RADER ^ DAUG7ERT
200/4 E&)a& &' $#&),)%!a& (r %+ #$l" !" l,(!"& .)r,l,$"r!"& $l"&)"rl "&)"r,9,$a!
" -,)a+,#a& l,(&&l-",&/ " %+a $a+a!a ")"r#a !" 9&9l,(!"& " (r)"#a& .ALVARE_
LEITE ") al4 2003/ .FIGURA 1/4 D" a$r! $+ &%a r,"+ $+(&,*' !"#&,!a!" "
)a+a#h a& l,((r)"#a& (!"+ &"r $la&&,9,$a!a& "+5 %,l+$r#& l,((r)"#a& !" +%,)a
ba,a !"#&,!a!" .VLDL$/ l,((r)"#a& !" !"#&,!a!" ,#)"r+"!,r,a l,((r)"#a !" ba,a!"#&,!a!" .LDL$/ " l,((r)"#a& !" al)a !"#&,!a!" .7DL$/ .RADER ^ `ILSON 1QQ/
&"#! a& l,((r)"#a& LDL$ " 7DL$ a& +a,& ab%#!a#)"& # (la&+a .RADER ^
DAUG7ERT 200/4
A 9%#*' (r,#$,(al !a& l,((r)"#a& (la&+),$a& (ar"$" &"r )ra#&(r)" !&
)r,l,$"r!"& " ! $l"&)"rl !& l$a,& !" r,"+ ] # ,#)"&),# .r,"+ ""#a/ " #
9a! .r,"+ "#!"#a/ ] (ara & l$a,& !" ar+a>"#a+"#) " %),l,>a*' .SC7IAVO ") al4
2003/ .FIGURA 2a/4
16
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MELO, A. L. Perfl lipoprotéico da população...
Fi+,ra -5 E&%"+a "+ $r)" !" %+a l,((r)"#a4 F#)"5 CANTO .2011/4
.5. UILOMICRONS
O& @%,l+$r#& &' &,#)"),>a!& #a& $l%la& ! ,#)"&),# " )ra#&(r)a+ $l"&)"rl "
)r,l,$"r!"& (r-"#,"#)"& !a !,")a (ara 9a! " )"$,!& ("r,9r,$&4 S' a& +a,r"&
(ar)$%la& l,((r),$a& (r"&"#)"& # &a#%" $+ )"r (r)",$ r"la),-a+"#)" ba,4 A
(r,#$,(al a((r)"#a (r"&"#)" a B4 O 9a! !"(%ra & %,l+$r#& r"+a#"&$"#)"& !a
$,r$%la*' )ra#&9"r,#! al%#& !& $+(#"#)"& l,(!,$& (ara %)ra l,((r)"#a a VLDL$
.COSTAN_O 2011/ .FIGURA 2a/4 A !&a"+ !" @%,l+$r#& "+ "ral #' a$r"&$"#)a
,#9r+a*H"& r"l"-a#)"& #a +a,r,a !& $a&& #' &"#! (r)a#) r"al,>a!a r),#",ra+"#)"
("l& labra)r,& $l#,$& .III DIRETRI_ES BRASILEIRAS 2001 NCEP 2001/4
.50 4LDL#COLESTEROL
A l,((r)"#a !" +%,) ba,a !"#&,!a!" &,#)"),>a!a # 9a! " )ra#&(r)a
)r,l,$"r!"& " "+ +"#r ,#)"#&,!a!" $l"&)"rl (ara a& $l%la& a!,(&a& #!" &'
"&)$a!& % (ara )"$,!& +%&$%lar"& #!" (ar),$,(a+ ! +")abl,&+ $"l%lar .FIGURA
2b/4 A a((r)"#a (r"!+,#a#)" #"&)" $+(l" a B1004 Ta#) & %,l+$r#& %a#) a&
VLDL$ &9r"+ a a*' !" %+a "#>,+a (r"&"#)" # "#!)l, !"#+,#a!a l,(a&" l,((r),$a
a %al (r+-" h,!rl,&" !& )r,l,$"r!"& "ra#! $,!& ra& %" &' $a()a!& ("la&
$l%la&4
Para a)%ar "&)a "#>,+a r"%"r a (r"&"#*a !" ,#&%l,#a " !a a(l,((r)"#a CII "
9r)"+"#)" ,#,b,!a ("l& $,!& ra& %" 9%#$,#a $+ %+ +"$a#,&+ !" r")r17
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MELO, A. L. Perfl lipoprotéico da população...
al,+"#)a*' #"a),- .COSTAN_O 2011/4 E&)a l,((r)"#a )a+b+ #' !&a!a
r),#",ra+"#)" ("l& labra)r,& $l#,$& &"#! &%a $#$"#)ra*' "&),+a!a $#&,!"ra#!&"
%" "+ $#!,*H"& #r+a,& "%,-al" a %+ %,#) !a $#$"#)ra*' !& )r,l,$"r!"& %a#!
"&)" "(r"&& "+ +,l,ra+a& (r !"$,l,)r .NCEP 2001/4
.57 LDL#COLESTEROL
O& LDL$ 9r+a!& (r 9&9l,(!"& " )r,l,$"r!"& +a,& a& a((r)"#a& a(B &'
((%lar+"#)" $la&&,9,$a!a& $+ +a% $l"&)"rl4 E&)a& )+ a 9%#*' !" $arr"ar $l"&)"rl
$,r$%la#)" .)a#) !" r,"+ ""#a %a#) "#!"#a/ (ara )!& & )"$,!& "$") (ara
)"$,! h"(),$ .SPOSITO ") al4 200X/ .FIGURA 2b/4Para a $la&&,9,$a*' !a& $#$"#)ra*H"& !"&)a& l,((r)"#a& & -alr"& $#&,!"ra!&
!"&"-",& !"-"+ &"r +"#r"& %" 130 +;!L4 C#$"#)ra*H"& "#)r" 130 a 1Q +;!L &'
$#&,!"ra!& -alr"& l,+)r9"& %" ,#!,$a+ r,&$ !" a$+%l !" l,(!"& #& -a&&
&a#%#"&4 C#$"#)ra*H"& a$,+a !" 1Y0 +;!L &' $#&,!"ra!a& $+ al) r,&$ (ara
!"&"#-l-,+"#) !" !"#*a& $ar!,-a&$%lar"& &br")%! %a#! a&&$,a!a& a %)r& 9a)r"&
!" r,&$ .NCEP 2001/4
@%a#) +a,r"& a& $#$"#)ra*H"& !" l,((r)"#a& !" ba,a !"#&,!a!" +a,r )"+(!" ("r+a##$,a !"&)a& #a $rr"#)" &a#%#"a %" (!" 9a-r"$"r !"&"#-l-,+"#) !a
9r+a ,!a),-a !a& +"&+a&4 E&)a 9r+a ")r"+a+"#)" a)"r#,$a (r )"r +a,r 9a$,l,!a!"
a l,ar&" a& +a$r9a& " a& (ar"!"& !& -a&& .ANCE ") al4 2003/4
A& l,((r)"#a& !" ba,a !"#&,!a!" r"(r"&"#)a+ a(r,+a!a+"#)" !,& )"r*& !
$#)"! !" $l"&)"rl ! (la&+a " a,#!a )+ a 9%#*' !" &" l,ar a& r"$"()r"& !& )"$,!&
")rah"(),$& (ara 9r#"$,+"#) !" $l"&)"rl .SC7AEFER 2002/4 A("&ar ! ,+(r)a#)"
(a("l 9,&,l,$ !"&)a& l,((r)"#a& a "l"-a*' !" &%a& $#$"#)ra*H"& a$,+a !r"$+"#!a! "&) !,r")a+"#)" a&&$,a!a # (r#&),$ !" r,&$ !" a)"r&$l"r&" $r#ar,a#a4
.ANCE ") al4 2003/4
18
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MELO, A. L. Perfl lipoprotéico da população...
19
A
B
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MELO, A. L. Perfl lipoprotéico da população...
Fi+,ra .5 M")abl,&+ !a& L,((r)",#a&5 a/ C,$l& ""# "#!"# " )ra#&(r)" r"-"r&4 b/ M")abl,&+
h"(),$ !a& l,((r)"#a&4 F#)"5II CONSENSO BRASILEIRO SOBRE DISLIPIDEMIAS .1QQY/4
.58 DL#COLESTEROL
O& 7DL$ &' $+(&)& 9r+a!& ("la %#,' !" 9&9l,(!"& )r,l,$"r!"& "
a((r)"#a& a(A ((%lar+"#)" !"#+,#a!a& b+ $l"&)"rl $#&),)%"+ !" 20 a 30 !
$l"&)"rl ))al "+ ,#!,-!%& #r+a,& .LIMA GLANER 200Y/4 Al+ !a ,+(r)a#)" 9%#*'
!" $arr"ar $l"&)"rl $,r$%la#)" (ara 9a! 7DL$ )a+b+ $#)r,b%, (ara a (r)"*'
! l",) -a&$%lar $#)ra a a)"r#"&" !"-,! J r"+*' !" l,(!"& ,!a!& !a&
l,((r)"#a& !" ba,a !"#&,!a!" ,#,b,*' !a 9,a*' !" +l$%la& !" a!"&' " +#$,)& a
"#!)l, " "&),+%la*' !a l,b"ra*' !" ,! #)r,$ .SPOSITO ") al4 200X/4
C#$"#)ra*H"& !" l,((r)"#a& !" al)a !"#&,!a!" +"#r"& ! %" 3 +;!L (ara
h+"#& " +;!L (ara +%lh"r"& (r(,$,a+ %+ al) r,&$ (ara a !"(&,*' !" l,(!"& "
+#$,)& #a& (ar"!"& !& -a&& &a#%#"& (r #' $#&"%,r"+ )ra#&(r)ar %+a
%a#),!a!" &%9,$,"#)" !" $l"&)"rl (ara 9a! #!" "&)" +")abl,>a!4 A&&,+
$#$"#)ra*H"& a$,+a !"&)"& -alr"& "&)ab"l"$,!& (ara h+"#& " +%lh"r"& &' $#&,!"ra!a&
$+ !"&"-",& .NCEP 2001/4
U+a ba,a $#$"#)ra*' !" l,((r)"#a& !" al)a !"#&,!a!" & $#&,!"ra!a $+
r"al+"#)" (r"$%(a#)" %a#! a$+(a#ha!a !" "l"-a!a& $#$"#)ra*H"& !" l,((r)"#a& !"
ba,a !"#&,!a!" " !" )r,l,$r,!"& .SPOSITO ") al4 200X/4 @%a#) +a,r )"+( !"!
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MELO, A. L. Perfl lipoprotéico da população...
("r+a##$,a !"&)" !"&"%,lbr, +a,r"& a& $ha#$"& !" !"&"#-l-,+"#) !" a)"r&$l"r&"
.ANCE ") al4 2003/4
.59 TRIGLICERIDEOS
O& l,(!"& &' ar+a>"#a!& #a 9r+a !" )r,l,$"r!"& +l$%la& !" )r& $,!&
ra& .&a)%ra!& +#&&a)%ra!& % (l,,#&a)%ra!&/ a$(la!& a %+ l$l .l,$"rl/ (ara
$#&),)%r"+ r"&"r-a& !" "#"r,a4 D"("#!"#! !a &%a r,"+ (!"+ &"r $la&&,9,$a!& $+
"#!"# .&,#)"),>a! ("l (r(r, ra#,&+/ % ""# .(r-"#,"#)" !a al,+"#)a*'/
&"#! a r,"+ ""#a a %" r"(r"&"#)a a(r,+a!a+"#)" 0 !& %,l+$r#& $,r$%la#)"&
# &a#%" .LE7NINGER ") al 1QQ BANES 2000 MOTTA 2003/4 O& )r,l,$"r!"&""#& !"(&,)a+&" # )"$,! a!,(& #%+ (r$"&& %" !%ra a) Yh a(& a 9r+a*' !
%,l+$r#4 O& )r,l,$"r!"& "#!"#& &' &,#)"),>a!& ("l 9a! " )ra#&(r)a!& (r
VLDL$4 A &#)"&" " )ra#&(r)" !" )r,l,$"r!"& "#!"#& &' r"la),-a+"#)" ,#!"("#!"#)"&
!a !,")a ,+(&)a .MAR__OCO " TORRES 1QQQ BANES 2000 MOTTA 2003/4
A !")"r+,#a*' !& )r,l,$"r!"& (&&%, %+ -a&) &,#,9,$a! $l#,$ "&("$,al+"#)"
"+ &" )ra)a#! !" !"#*a& $r#ar,a#a& " a)"r&$l"r),$a&4 O !&"a+"#) !& )r,l,$"r!"&
!" +%,)a ,+(r)K#$,a )a+b+ (ara a-al,a*' !" %a!r& %" "#-l-"+ !,ab")"& +"ll,)%&b&)r%*H"& b,l,ar"& #"9r&"& " -r,& %)r& !,&)rb,& ! +")abl,&+ "#!$r,# .PIRES ")
al4 200/4
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D"&,#a+&" !,&l,(,!"+,a& % h,("rl,(,!"+,a& a& "l"-a*H"& &r,$a& !" %+ % +a,&
$+(#"#)"& &a#%#"& !"$rr"#)"& !" !,&)rb,& "+ %al%"r 9a&" ! +")abl,&+ l,(!,$.C7ACRA ") al4 200/4 E&)" "$"&& (!" l"-ar a a$+%l ,#)ra$"l%lar !" l,(!"& "
!"(&,*' !& +"&+& "+ -a&& " )"$,!& "ra#! a%+"#) ! r,&$ $ar!,-a&$%lar % a)
+"&+ (a)l,a& )a,& $+5 a)"r&$l"r&" ,#9ar) a%! ! +,$r!, "&)"a)&" h"(),$a
b"&,!a!" D,ab")"& M"ll,)%& T,( II "#)r" %)ra& .FIL7O 2000/4
A $#$"#)ra*' (la&+),$a "l"-a!a !" LDL$ )"+ r"la*' !,r")a $+
!"&"#-l-,+"#) !" !"#*a ar)"r,al $r#ar,a#a " a ba,a $#$"#)ra*' (la&+),$a !" 7DL$
)+ &,! a(#)a!a& $+ %+ !& +a,& 9r)"& 9a)r"& !" r,&$ ,#!"("#!"#)"& (ara a !"#*a
a)"r&$l"r),$a $r#ar,a#a4 O%)ra& "-,!#$,a& ,#!,$a+ %" a%+"#)& +!"&)& #&
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MELO, A. L. Perfl lipoprotéico da população...
)r,l,$"r!"& a%+"#)a+ r,&$ !" "-"#)& $r#ar,a#& " a (rr"&&' !a !"#*a ar)"r,al
$r#ar,a#a $+ )a+b+ a 9r+a*' !" #-a& l"&H"& .GUEDES " GONALVES 200X
PENALVA ") al4 200 COEL7O ") al4 200 FRANCA ") al4 200Y/4
.5< ATEROSCLEROSE
S"%#! La%r,#! .2000/ a a)"r&$l"r&" %+ 9r)" 9a)r (ara $r"&$,+"#) !a
+r)al,!a!" (r !"#*a& $ar!,-a&$%lar"& .DCV/ r"(r"&"#)a#! #a +a,r,a !& (a&"& "#)r"
30 a 3 !" )!a& a& $a%&a& !" b,)4 ? # Bra&,l &"%#! a DATASUS "+ 2010
$rr"ra+ X4Q00 b,)& "+ ,#!,-!%& $+ ,!a!" ,%al % &%("r,r a 0 a#& (r
$#&"%#$,a !" !"#*a& ! a(ar"lh $,r$%la)r, .STEFANINI =ASINS=I " CARVAL7O200/4
A a)"r&$l"r&" %+ (r$"&& +%l),9a)r,al (rr"&&,- " l"#) # %al h al)"ra*'
#a (ar"!" ar)"r,al .GOTTLIEB ") al4 200/4 A #"&" !a 9r+a*' !a (la$a !" a)"r+a
b,l,$a $+(l"a #!" h %+ $r"&$,+"#) (rr"&&,- !" l,((r)"#a #a $a+a!a ,#)ra "
")ra$"l%lar a&&$,a! a %+ (r$"&& $"l%lar (rl,9"ra),- l"-a#! a !,&9%#*' "#!)"l,al "
al)"ra#! a +a)r,> ")ra$"l%lar " $a&,#a#! !"(&,) !" )r+b .FIGURA 3/
.LAURINDO 2000/4
Fi+,ra 05 Pr$"&& !" 9r+a*' !a (la$a a)"r&$l"r),$a4 F#)"5 A!a()a! ! ba#$ !" ,+a"#& A4D4A4M4
A 9r+a*' !a a)"r&$l"r&" !"-,! J (r"&"#*a !" 9a)r"& !" r,&$& %" a)%a+ &br"
"#!)l, !a& ar)r,a& $a&,#a#! a a%&#$,a !" +"!,a!r"& a%)(r)")r"& # 9$ ! l",)
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MELO, A. L. Perfl lipoprotéico da população...
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MELO, A. L. Perfl lipoprotéico da população...
75 METODOLOGIA
75- AMOSTRAGEM
A ("&%,&a 9, &%b+"),!a J Plataforma Brasil (ara &"r !,r"$,#a! a C+,) !" \),$a
"+ P"&%,&a $+ S"r"& 7%+a#& " a&&,+ a)"#!"#! a& #r+a& ! C#&"lh Na$,#al !"
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0 a#& "+ !,a#)" %&%r,& ! S,&)"+a #,$ !" Sa!" .SUS/ " !a r"!" (ar),$%lar #&
r"9"r,!& +%#,$(,& ))al,>a#! Q1 ,#!,-!%&4
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75. CRITÉRIOS DE INCLUSÃO
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O& Da!& 9ra+ $l")a!& # ("r! !" N-"+br !" 2012 a ?a#",r !" 2013 a
(ar),r ! $a!a&)r !" "#)ra!a !& (a$,"#)"& r"&,!"#)"& #a r",' !" "&)%!4
#.$AN1LISE LABORATORIAL
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LAB .T,+baba PE/ "+ a+&)ra& !" &a#%" . +L/ $l")a!a& "+ )%b& Vacutainer " &r
9, &"(ara! !a& h"+$,a& (r $"#)r,9%a*' (ara a !&a"+ !" $l"&)"rl 7DL4 A !&a"+
"#>,+),$a !" 7DL$ 9, (r"$"!,!a ("la (r"$,(,)a*' !" LDL$ (r"&"#)" #& &r& +"!,a#)"
%& !" r"a"#)"& r"&(#&,-& J &"(ara*' +a#),$a $#)"#! &%l9a) !" !")ra# " $lr") !"
+a#&, . Katal /4 A !")"r+,#a*' !" LDL$ (ara TG &r,$ aba, !" 00+;!l 9, b),!a ("l $l$%l !" Fr,"!"al!5 LDL$ W CT c 7DL$ c TG; .A#!r,l A 2000 III D,r")r,>"&
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MELO, A. L. Perfl lipoprotéico da população...
85 RESULTADOS
A r",' !a Ma)a Nr)" ! "&)a! !" P"r#a+b%$ $+(r""#!" 1Q +%#,$(,& !"#)r"
& %a,& %a)r 9ra+ b") ! "&)%! .Al,a#*a Ca+%)a#a F"rr",r& " T,+baba/4 N'
h%-" #"#h%+ (rbl"+a )$#,$ "#)r" )!a& a& Q1 a+&)ra& &a#%#"a&4 A +"!,a#a !" ,!a!"
9, !" Q a#& ha-"#! !,9"r"#*a& !a +"&+a "+ r"la*' a &" .7+"+ W X M%lh"r W
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0 a Y0 Q 3
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"#%a!r%&" $+ (r)a!r"& !"&&a (a)l,a4 O,) (a$,"#)"& a(r"&"#)ara+ al)"ra*H"& #a&
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DL#$+*H
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a-a#* !a ,!a!" !& (a$,"#)"& r"&("$),-a+"#)"4
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MELO, A. L. Perfl lipoprotéico da população...
R 2 W 00Q 8 W 1Y13 e 21X32 #!" R 2 W $"9,$,"#)" !" $rr"la*' !" P"ar&# 8 W "%a*' !a r")a4
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&,! -"r,9,$a!a al)"ra*' &,#,9,$a),-a !& #-",& !" 7DL$ .R 2 W 0001/ " )a+(%$ !"
LDL$ .R 2 W 00Q/ $+ "#-"lh"$,+"#)4 Ta,& a$ha!& #' ("r+,)"+ a9,r+ar % #"ar a
,#9l%#$,a !a ,!a!" #a al)"ra*' !& #-",& !a& r"9"r,!a& l,((r)"#a&4
6. DISCUSSÃO
7 al%+ )"+( a& %"&)H"& r"la$,#a!a& J& +%!a#*a& 9,&,l,$a& " J& !"#*a&
)(,$a& ! "#-"lh"$,+"#) )+ !"&("r)a! (r"$%(a*' #a $+%#,!a!" $,"#)9,$a4 C+ ,&&
"&)%!& )+ &,! r"al,>a!& $+ ("&&a& !" ,!a!" a-a#*a!a " ,!&& "+ )! +%#!
abr!a#! !,9"r"#)"& %"&)H"& r"la$,#a!a& J -"lh,$" a ""+(l ! ("r9,l l,(!,$ r"la$,#a!
a "&),l !" -,!a )"+a& ("&%,&a!& "+ !,9"r"#)"& (a&"& .CURB ") al4 200 MILIONIS ")
al4 200Y CASLA=E ") al4 2010/ $+ $a& ! Bra&,l .G%"!"& " G%"!"& 1QQFREITAS ") al4 200Q/4
N"&)" "&)%! a("&ar !" %+ r"!%>,! "&(a* a+&)ral 9, -"r,9,$a!a (r"!+,#K#$,a !"
(a$,"#)"& ! &" 9"+,#,# .X23/4 R"&%l)a! &"+"lha#)" 9, "#$#)ra! "+ %)ra&
("&%,&a& r"al,>a!a& # Bra&,l .FERREIRA ") al4 2010/4 Fa) %" (!" &"r a)r,b%! J +a,r
"("$)a),-a !" -,!a "#)r" a& +%lh"r"& " J +a,r )aa !" +r)al,!a!" "#)r" & h+"#& -"#&
& %a,& &' +a,& "(&)& a a$,!"#)"& !" )rabalh a "),l,&+ a )aba,&+ J +r)" (r
$a%&a& ")"r#a& !"#*a& $ar!,-a&$%lar"& " #"(la&,a& .VERAS 200/4
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MELO, A. L. Perfl lipoprotéico da população...
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+a,r,a !& l%ar"& r"&%l)a#! "+ %+a +a,r (r(r*' !" +%lh"r"& "+ r"la*' a& h+"#&
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200Y/4 S"%#! P"r",ra ") al4 .200/ "&&" 9"#+"# (!" &"r "(l,$a! (r 9a)r"& b,l,$&
" &$,$%l)%ra,&4 N "#)a#) (r"!+#, !" +%lh"r"& "+ r"la*' a& h+"#& #a r",' !a
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h+"#& 9, Y +;!L4 E+ "&)%! realizado $+ a!%l)& " ,!&& # +%#,$(, !" Ca+(&
!& G8)a$a>"&;R? -"r,9,$%&" %" & #-",& !" 7DL$ 9ra+ &%("r,r"& "#)r" & h+"#&
,!&& .SOU_A ") al4 2003/4 A("&ar !a !,9"r"#*a "#$#)ra!a (ara & -alr"& !a +!,a "#)r"
& &"& #"&)" "&)%! a& +%lh"r"& #r+al+"#)" a(r"&"#)a+ #-",& !" 7DL$ +a,& "l"-a!&
%" & h+"#& " (r ,&& & -alr"& r"$+"#!a!& $+ !"&"-",& (ara 7DL$ -ar,a "#)r"
& &"& .PO__AN 200/4O -alr +!, al)"ra! !" 7DL$ .31 +;!L/ "#$#)ra! "#)r" a& +%lh"r"& !"&)"
"&)%! "-,!"#$,a a #"$"&&,!a!" !" -,,lK#$,a !" 9a)r"& !" r,&$ %+a -"> %" #-",& !" 7DL
$ ,#9"r,r"& a 0 +;!L (a&&a+ a &"r 9a)r !" r,&$ ,#!"("#!"#)" (ara !"#*a ar)"r,al
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,+(a$) #a ,#$,!#$,a !" !"#*a $ar!,-a&$%lar "+ +%lh"r"& ! %" "+ h+"#&"&("$,al+"#)" a%"la& #a 9a&" !" +"#(a%&a .GRAVINA ") al4 2010/4
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MELO, A. L. Perfl lipoprotéico da população...
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LDL$ ,!a! al)"ra a 9%#*' ! "#!)l, a%+"#)a#! a -%l#"rab,l,!a!" ! -a& (ara a
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& -"#& +a& &" &ab" %" -r,& 9a)r"& !" r,&$ %" &" a$%+%la+ a l# !& a#& (!"+
&" a&&$,ar " ,#9l%"#$,ar #a (r"!,&(&,*' (ara &%r,+"#) !a a)"r&$l"r&" .LIMA "FONOLLOSA 2003/4
E#)r" & r%(& ")r,& & #-",& !" LDL$ $#),#%ara+ &%("r,r"& "#)r" a& +%lh"r"&4
F, -"r,9,$a! (r S%>a ") al4 %" #-",& !" LDL$ +&)rara+&" &,#,9,$a),-a+"#)"
&%("r,r"& "#)r" a& +%lh"r"& "+ )!& & r%(& ")r,&4 Da!& ! NHANES Study +&)ra+
%" h+"#& $+ ,!a!" "#)r" 30 " Q a#& a(r"&"#)ara+ #-",& +!,& !" LDL$ +a,r"& %"
& !a& +%lh"r"& !" +"&+a ,!a!" +a& # r%( $+ X0 a#& % +a,& a& +%lh"r"&
a(r"&"#)ara+ +a,r +!,a !" LDL$ %" & h+"#&4 N Turku Elderly Study .UPMEIER ")al4 2011/ , 9ra+ "#$#)ra!& -alr"& &,#,9,$a),-a+"#)" +a,r"& !" LDL$ "+ +%lh"r"&
,!&a& #a& )r& a-al,a*H"& r"al,>a!a& a l# !" 1 a#& !" &"%,+"#)4
O& a$ha!& !"&)" "&)%! a(r"&"#)a+ al%+a& l,+,)a*H"& $+ #+"r r"la),-a+"#)"
("%"# !" (a$,"#)"& "a+,#a!& $+(ara! $+ %)r& "&)%!& " a a%&#$,a !" %+
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&%9,$,"#)" (ara (r"&%+,r $+ $"r)">a %+a (&&-"l D"#*a Ar)"r,al Cr#ar,a#a4
D,a#)" !a& b&"r-a*H"& "(&)a& 9a>&" #"$"&&r, a(r9%#!ar "&&" "&)%! a)ra-& !"
%+ l"-a#)a+"#) !" %)ra& -ar,-",& %" (!"+ "&)ar a,#! (ara %" "&)"a+ ,#&)ala!&
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MELO, A. L. Perfl lipoprotéico da população...
"&&"& #-",& !" !,&l,(,!"+,a& # &" 9"+,#,# )a,& $+5 hb,)& al,+"#)ar"& &br"("&
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,&& b") !" 9%)%ra& ("&%,&a&4
:5 CONCLUS;ES
A& !"#*a& $ar!,-a&$%lar"& r"(r"&"#)a+ %+ ra#!" (rbl"+a !" &a!" (bl,$a #
Bra&,l #"ra#! $%&)& # a)"#!,+"#) " #a& ba,a& h&(,)alar"&4 D"-"&" (r)a#)
,#)"#&,9,$ar "&9r*& #a !")"$*' (r"$$" (r"-"#*' " #a "!%$a*' "+ &a!" (ara +,#,+,>ar
"&&"& ara-& %" )a#) $a%&a+ (r"%>& J %al,!a!" !" -,!a !a ((%la*'4
O& !a!& a%, a(r"&"#)a!& al"r)a+ (ara a #"$"&&,!a!" !" ,#$"#),- J& +"!,!a& !"
"&),l !" -,!a &a%!-"l #a r"9"r,!a ((%la*' (r,#$,(al+"#)" # %" !,> r"&(",) J (r),$a !"a),-,!a!" 9&,$a " a hb,)& al,+"#)ar"& &a%!-",&4
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MELO, A. L. Perfl lipoprotéico da população...
<5 REFER=NCIAS
ALVARE_LEITE ?4I4 OLIVEIRA D4R4 PELU_IO M4C4G4 D,&l,(,!"+,a&4 I#5 NETO F4T4.E!4/ N%)r,*' Cl#,$a4 R, !" ?a#",r5 G%a#abara =a# (41QY211 20034
BALTALI M GO=CEL A =I_ILTAN 7T =OR=MA_ ME TOPCU S ALCIN F ") al4A&&$,a),# b")""# )h" +")abl,$ &8#!r+" a#! #"l8 !,a#&"! $r#ar8 h"ar) !,&"a&"4D,ab")"& N%)r M")ab4 1Y.3/51YQX 20034
BANES DOMINIC_A=4 B,%+,$a M!,$a4 14 "!4 S' Pa%l5 Ma#l" (4 YY 20004
CAMARANO AA4 E#-"lh"$,+"#) !a ((%la*' bra&,l",ra5 %+a $#)r,b%,*' !"+r9,$a4I#5 Fr",)a& EV ") al4 Tra)a! !" G"r,a)r,a " G"r#)l,a4 24 "!4 R, !" ?a#",r5 G%a#abara=a# (4 10 200Y4
CARROLL MD LAC7ER DA SORLIE PD CLEEMAN ?I GORDON D? `OL_ M ") al4Tr"#!& ,# &"r%+ l,(,!& a#! l,((r)",#& 9 a!%l)& 1QY020024 ?AMA4 200 2Q5 1XX314
CASLA=E M? PAC=ARDA C? ROBERTSONB M COONEA ? NELSONC ?? FORDBI ") al4 L,((r)",#a&&$,a)"! (h&(hl,(a&" A ,#9la++a)r8 b,+ar6"r& a#! r,&6 9 $ar!,-a&$%lar !,&"a&" ,# )h" Pr&("$),-" S)%!8 9 Pra-a&)&),# ,# )h" El!"rl8 a) R,&6 .PROSPER/4 A)h"r&$l"r&,&4 2105 23 20104
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MELO, A. L. Perfl lipoprotéico da população...
C7ACRA ANA P4 M4 SANTOS RAUL D4 Abr!a"+ )"ra(%),$a !a& !,&l,(,!"+,a& "+&,)%a*H"& "&("$,a,&5 h,("r$l"&)"rl"+,a 9a+,l,ar h+>,),$a r"9ra)r,a4 R"-,&)a !aS$,"!a!" !" Car!,l,a ! "&)a! !" S' Pa%l4 -4 1 #4 Y (4 323X 2004
C7AMPE P4 C4 7ARVE R4 A4 FERRIER D4 R4 L,(,!& +")abl,&+4 I#5 B,$h"+,&)r8 a"!,*' 200X 20(4
COEL7O VANESSA G4 CAETANO LOENI F4 LIBERATORE ?UNIOR RAP7AEL D4 R4") al4 P"r9,l l,(!,$ " 9a)r"& !" r,&$ (ara !"#*a& $ar!,-a&$%lar"& "+ "&)%!a#)"& !"+"!,$,#a4 Ar%,-& Bra&,l",r& !" Car!,l,a -4 #4 1 (4 XY2 2004
COSTAN_O LINDA S4 F,&,l,a4 4 "!4 S' Pa%l5 El&"-,"r 20114
CURB ?D ABBOTT RD RODRIGUE_ BL MASA=I =7 C7EN R POPPER ?S ") al47,h !"#&,)8 l,((r)",# $hl"&)"rl a#! )h" r,&6 9 &)r6" ,# "l!"rl8 +"#4 A+ ? E(,!"+,l4
1Y0.2/5 101X 2004
EDUARDO CANTO4 C,#$,a& Na)%ra,&5 A(r"#!"#! $+ $),!,a#4 E!4 M!"r#a 3f"!,*' 20114
FERREIRA C4C4C4 PEI<OTO M4R4G4 BARBOSA M4A4 SILVEIRA E4A4 Pr"-al#$,a !"Fa)r"& !" R,&$ Car!,-a&$%lar "+ I!&& U&%r,& ! S,&)"+a [#,$ !" Sa!" !" G,K#,a4Ar Bra& Car!,l Q./5 Y21Y2 20104
FIL7O GERALDO B4 Bl,l Pa)l,a4G%a#abara =a#5 R, !" ?a#",r"!4 Y (4 2Q33QX 20004FRANCA EVERALDO ALVES ?OgO G4 B4 D,&l,(,!"+,a "#)r" Cr,a#*a& " A!l"&$"#)"&!" P"r#a+b%$4 Ar%,-& Bra&,l",r& !" Car!,l,a -4 X #4 Y (4 X22X2X 200Y4
FRANSSEN R4 MONA?EMI 74 TROES E4S4G4 =ASTELEIN ?4?4P4 Ob"&,)8 a#!D8&l,(,!"+,a4 E#!$r,#l8 ^ M")abl,&+ Cl,#,$& 9 Nr)h A+"r,$a -43X (4 Y23 c Y332004
FREITAS EV BRANDgO AA PO__AN R MAGAL7gES ME FONSECA F PI__I O ")al4 I+(r)K#$,a !a 7DL$ (ara $rr#$,a !" !"#*a $ar!,-a&$%lar # ,!&4 Ar Bra&Car!,l4 Q3.3/5 231 200Q4
FRIEDE`ALD `4T4 LEV R4I4 FREDRIC=SON D4S4 E&),+a),# 9 )h" $#$"#)ra),# 9 l!"#&,)8 l,((r)",# $hl"&)"rl ,# (la&+a ,)h%) %&" 9 )h" (r"(ara),-" %l)ra$"#)r,9%"4Cl,# Ch"+4 15QQ02 1QX24
GOTTLIEB M4 G4 V BONARDI G MORIGUC7I E4 74 F,&,(a)l,a " a&("$)&,#9la+a)r,& !a A)"r&$l"r&"4 S$,"#),a M"!,$a4 Pr) Al"r"5 PUCRS -4 1 #4 3 ?%l;S")42004
GRAVINA CF ROSA RF FRAN=EN RA FREITAS EV LIBERMAN A ") al4 S$,"!a!"Bra&,l",ra !" Car!,l,a4 II D,r")r,>"& Bra&,l",ra& "+ Car!,"r,a)r,a4 Ar Bra& Car!,l4 Q .3
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MELO, A. L. Perfl lipoprotéico da população...
GUEDES DP GUEDES ?ERP4 D,&)r,b%,*' !" r!%ra $r(ral (r"&&' ar)"r,al " #-",& !"l,(!"&l,((r)"#a& (la&+),$a&4 Ar Bra& Car!,l4 X0 .2/5 Q3 1QQ4
GUEDES DARTAGNAN P4 E GONALVES LEANDRO A4V4 I+(a$) 9 )h" hab,)%al
(h8&,$al a$),-,)8 # l,(,! (r9,l" ,# a!%l)&4 Ar%,-& Bra&,l",r& !" E#!$r,#l,a "M")abl,a4 -4 1 #4 1 (4 X2X 200X4
7ALPERN M?4 B,%+,$a4 E!4 r"-4 L,&ba5 LIDEL 1QQX4 Pr)%%"&"
II CONSENSO BRASILEIRO SOBRE DISLIPIDEMIAS4 D")"$*' a-al,a*' ")ra)a+"#)4 Ar Bra& Car!,l YX511Y 1QQY4
III DIRETRI_ BRASILEIRA SOBRE DISLIPIDEMIA E DIRETRI_ES DE PREVENgODA ATEROSCLEROSE DO DEPARTAMENTO DE ATEROSCLEROSE DA SOCIEDADEBRASILEIRA DE CARDIOLOGIA4 Ar Bra& Car!,l XX51 20014
INGELSSON E MASSARO ?M SUT7ERLAND P ?AC@UES PF LEV DDAGOSTINO RB ") al4 C#)"+(rar8 )r"#!& ,# !8&l,(,!"+,a ,# )h" Fra+,#ha+ 7"ar)S)%!84 Ar$h I#)"r# M"!4 1YQ .3/5 2XQY 200Q4
LAURINDO FRANCISCO RAFAEL MARTINS4 F,&,(a)l,a !a A)"r&$l"r&"4 IN5SILVA MAURICIO ROC7A4 F,&,(a)l,a Car!,-a&$%lar4 E!,)ra A)h"#"%4 S' Pa%lSP (4 11132 20004
LE7NINGER ALBERT L4 NELSON DAVID L4 CO< MIC7AEL M4 Pr,#$(,& !"B,%+,$a4 24 "!4 S' Pa%l5 Sar-,"r 1QQ4
LIMA ? FONOLLOSA V VILARDELL M4 A)"r#"&,&4 Fa$)r"& !" r,"& $ar!,-a&$%lar "# "l a#$,a#4 R"- M%l) G"r#)l4 13.3/5 1YY0 20034
LIMA 4̀ A4 GLANER M4 F4 Pr,#$,(a,& 9a)r"& !" r,&$ r"la$,#a!& J& !"#*a&$ar!,-a&$%lar"&4 R"-,&)a Bra&,l",ra !" C,#"a#)r(+")r,a " D"&"+("#h 7%+a# -4 #4 1
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MANSO C4 B,%+,$a h%+a#a4 3f "!4 L,&ba5 F%#!a*' Cal%&)" G%lb"#6,a# 1QY4Pr)%%"&"4
MARTINE_ TiNIA LEME DA ROC7A VALE ANDR\IA LOURES4 A)"r&$l"r&"")ra$r#r,a5 E),l,a R"la*' $+ a $r#ar,(a),a& " "&)ra),a& # )ra)a+"#)4 R"-,&)aS$,"!a!" !" Car!,l,a ! E&)a! !" S' Pa%l4 Vl4 10 #j Y N-;D"> 2000 (424
MAR__OCO ANITA TORRES BAARDO BAPTISTA4 B,%+,$a B&,$a4 24 "!4 R, !"?a#",r5 G%a#abara =a# 1QQQ4
MILIONIS 7? FILIPPATOS TD LOU=AS T BAIRA=TARI ET TSELEPIS AD ELISAFMS4 S"r%+ l,((r)",#.a/ l"-"l& a#! a(l,((r)",#.a/ ,&9r+ &,>" a#! r,&6 9r 9,r&)"-"r a$%)" ,&$ha"+,$ ##"+bl,$ &)r6" ,# "l!"rl8 ,#!,-,!%al&4 A)h"r&$l"r&,&4 1X5 1X0Y 200Y4
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NCEP E"$%),-" S%++ar8 9 )h" Th,r! R"(r) 9 )h" Na),#al Chl"&)"rl E!%$a),#Prra+4 E("r) Pa#"l # D")"$),# E-al%a),# a#! Tr"a)+"#) 9 7,h Bl! Chl"&)"rl ,#A!%l)& .A!%l) Tr"a)+"#) Pa#"l III/4 E("r) Pa#"l # D")"$),# E-al%a),# a#! Tr"a)+"#) 9 7,h Bl! Chl"&)"rl ,# A!%l)&4 ?%r#al 9 A+"r,$a# M"!,$al A&&$,a),# -4 2 #4 1Q (42Y2QX 20014
PENALVA RAFAELA A4 7UOA MARAL O4 CORREIA LUIS C4 L4 ") al4 L,(,! (r9,l" a#! ,#)"#&,)8 9 a)h"r&$l"r&,& !,&"a&" ,# a$%)" $r#ar8 &8#!r+"4 Ar%,-&Bra&,l",r& !" Car!,l,a -4 Q0 #4 1 (4 230 2004
PEREIRA ?C BARRETO SM PASSOS VMA4 O ("r9,l !a &a!" $ar!,-a&$%lar !& ,!&& bra&,l",r& (r"$,&a +"lhrar5 "&)%! !" ba&" ((%la$,#al4 Ar Bra& !" Car!,l4 Q1.1/5 1102004
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PO__AN R PO__AN R MAGAL7gES MEC BRANDgO AA BRANDgO AP4D,&l,(,!"+,a &#!r+" +")abl,$a " r,&$ $ar!,-a&$%lar4 R"-,&)a !a SOCER?4 1X .2/5 Q210 2004
RADER D4?4 DAUG7ERT A4 Tra#&la),# +l"$%lar !,&$-"r,"& ,#) #" )h"ra(,"& 9r a)h"r&$l"r&,&4 Na)%r" -41 (4Q0Q13 2004
RADER D4?4 `ILSON ?4M4 G"#" )h"ra(8 9r l,(,! !,&r!"r&4 I#5 7ARBER E4 .E!4/4
Ml"$%lar $ar!,-a&$%lar +"!,$,#"4 N" r65 S$,"#),9,$ a+"r,$a# (4QX11 1QQ4ROC7A VIVIANE _OR_ANELLI LIBB PETER4 B,l,a Va&$%lar Da A)"r&$l"r&" "$+(l,$a*H"& A%!a& ! A)"r+a4 IN5 NOBRE FERNANDO SERRANO CARLOS V4Tra)a! !" Car!,l,aSOCESP4 Bar%"r, SP4 E!4 Ma#l" (4 2004
SALGADO CDS4 M%lh"r ,!&a5 a 9"+,#,>a*' !a -"lh,$"4 E&)%! I#)"r!,&$,( E#-"lh"$4 5 X1Q 20024
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SC7IAVO M4 LUNARDELLI A4 OLIVEIRA ?4 R4 I#9l%#$,a !" )r,l,$r,!"& #a$#$"#)ra*' &r,$a !" )r,l,$r,!"&4 ?r#al Bra&,l",r !" Pa)l,a " M"!,$,#a Labra)r,al -43Q #4 (4 232Q 20034
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UPMEIER E LAVONIUS S 7EINONEN P VIITANEN M ISOA7O 7 ARVE S ") al4L#,)%!,#al $ha#"& ,# &"r%+ l,(,!& ,# l!"r ("(l" Th" T%r6% El!"rl8 S)%!8 1QQ1c200Y4A" A",#4 0 .2/5 203 20114
VERAS R4 A "ra !& ,!&&5 !"&a9,& $#)"+(rK#"&4 I#5 Sal!a#ha AL Cal!a& CP .Or4/4Sa!" ! ,!&5 a ar)" !" $%,!ar4 2f "!4 R, !" ?a#",r5 I#)"r$,#$,a 2004 (43104
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MELO, A. L. Perfl lipoprotéico da população...
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MELO, A. L. Perfl lipoprotéico da população...
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