Reactions 1459 - 6 Jul 2013 S Pregabalin Various toxicities: 3 case reports Three women developed various toxicities while receiving pregabalin [routes not stated] to treat restless legs syndrome (RLS), fibromyalgia syndrome and neuropathic pain. A 42-year-old woman was diagnosed with RLS and fibromyalgia syndrome, and started pregabalin 75mg twice daily. After 2 days, she presented with complaints of sedation and vertigo. The woman was advised that these side effects would resolve with time. At follow-up 15 days later, she reported that the sedation and vertigo had resolved, and her RLS symptoms had improved by > 50%. Her pregabalin dose was subsequently increased to 150mg twice daily, with > 90% relief of her RLS and pain symptoms. A 38-year-old woman was diagnosed with RLS and diabetic neuropathic pain, and subsequently commenced on pregabalin 75mg twice daily; she also had lumbar disc herniation. She was admitted 1 week later, due to complaints of vertigo, fatigue and a tendency to sleep. These side effects resolved within 1 week. Her pregabalin dose was subsequently increased to 150mg twice daily, improving her RLS symptoms by 80%. A 48-year-old woman was diagnosed with RLS and myofascial pain syndrome, and was started on pregabalin 75mg twice daily [duration of therapy before reaction onset not clearly stated]. She was advised about side effects to pregabalin, such as dizziness, sleepiness and vertigo. At her follow-up visit 1 week later, the woman reported experiencing similar side effects initially, but said they had resolved within 4–5 days. Her pregabalin dosage was subsequently increased to 150mg twice daily, complete relief of her RLS and pain symptoms after 3 months. Author comment: "Side effects, such as headache, vertigo, rash, dry mouth and a tendency to sleep may be observed, particularly with initial doses of pregabalin, but resolve with time. Similar minor side effects were observed in the three cases in this case series, but were relieved within one week". Karatay S, et al. Pregabalin in the treatment of primary and secondary restless legs syndrome: Three case reports. Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi 57: 242-244, No. 4, 2011. Available from: URL: http://dx.doi.org/10.4274/tftr.27122 - Turkey 803089468 1 Reactions 6 Jul 2013 No. 1459 0114-9954/10/1459-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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Reactions 1459 - 6 Jul 2013

SPregabalin

Various toxicities: 3 case reportsThree women developed various toxicities while receiving

pregabalin [routes not stated] to treat restless legs syndrome(RLS), fibromyalgia syndrome and neuropathic pain.

A 42-year-old woman was diagnosed with RLS andfibromyalgia syndrome, and started pregabalin 75mg twicedaily. After 2 days, she presented with complaints of sedationand vertigo. The woman was advised that these side effectswould resolve with time. At follow-up 15 days later, shereported that the sedation and vertigo had resolved, and herRLS symptoms had improved by > 50%. Her pregabalin dosewas subsequently increased to 150mg twice daily, with > 90%relief of her RLS and pain symptoms.

A 38-year-old woman was diagnosed with RLS and diabeticneuropathic pain, and subsequently commenced onpregabalin 75mg twice daily; she also had lumbar discherniation. She was admitted 1 week later, due to complaintsof vertigo, fatigue and a tendency to sleep. These side effectsresolved within 1 week. Her pregabalin dose wassubsequently increased to 150mg twice daily, improving herRLS symptoms by 80%.

A 48-year-old woman was diagnosed with RLS andmyofascial pain syndrome, and was started on pregabalin75mg twice daily [duration of therapy before reaction onset notclearly stated]. She was advised about side effects topregabalin, such as dizziness, sleepiness and vertigo. At herfollow-up visit 1 week later, the woman reported experiencingsimilar side effects initially, but said they had resolved within4–5 days. Her pregabalin dosage was subsequently increasedto 150mg twice daily, complete relief of her RLS and painsymptoms after 3 months.

Author comment: "Side effects, such as headache, vertigo,rash, dry mouth and a tendency to sleep may be observed,particularly with initial doses of pregabalin, but resolve withtime. Similar minor side effects were observed in the threecases in this case series, but were relieved within one week".Karatay S, et al. Pregabalin in the treatment of primary and secondary restless legssyndrome: Three case reports. Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi 57:242-244, No. 4, 2011. Available from: URL: http://dx.doi.org/10.4274/tftr.27122 -Turkey 803089468