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Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台台台台台台台 台台台 台台台台台台台 2006 台台台台台台台台台台

Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

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Page 1: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Prenatal Diagnostic Ultrasound in Application of Umbilical Cord

台北榮總婦產部 陳志堯洪正修主任指導

2006年中華醫用超音波年會

Page 2: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

媽媽的慈繩愛索

Page 3: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

What Ultrasound Can Do?

Page 4: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

In Diagnosis

• Vessel Number: Normal cord has 3 vessels encased in Wharton jelly. (2A1V)

– Arteries flanking the bladder.

• Cord Coiled: Arteries coil around vein.

• Connections: Abdominal wall & central placenta. (vesa previa, velamentous insertion)

Page 5: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 6: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 7: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Cord Length (50~60 cm)

• Short cord– Akinesia sequence– Trisomy 21– Body stalk anomalies

• Long cord– Hyperactivity– Increased likelihood of true cord knot

Page 8: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Morphological Abnormalities

Page 9: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Single Umbilical Artery

• 3% in 1st trimester, 1~2% 2nd tri., 0.63% newborn.

• 70% absent LT UA, 30% RT

• Size is larger than 3 vessel cord UA

• Less coiled

• 15% develop IUGR

• Non-isolated SUA: 50% aneuploidy (T18 & 13)

• D/D– Fused UAs.

– Umbilical vessel thrombosis

– Excessive Wharton jelly

Page 10: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 11: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 12: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 13: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Umbilical Cord Cyst (UCC)

• Para-axial (60%), axial (40%), mid-UC (39%)• 2% in 1st trimester, 2nd~3rd trimester: aneuploidy

(T18 & T13)• Single UCC (75%): good prognosis• Multiple UCC (25%): 2/3 aneuploidy & anomalies.• D/D

– Normal yolk sac– UC aneurysm– Resolving UC hematoma (rare)– UC supernumerary vessels (very rare, conjoined twins)

Page 14: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
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Umbilical Cord Aneurysm (UCA)

• UV varix (UV > 9mm)– May associated with persistent Rt umbilical vein

– Between abdominal insertion site and inferior liver

– May be large

• UA aneurysm– May have A-V fistula to UV

– Associated with multiple anomalies (T18)

– Near placental origin

– More rare than UV varix; wall may be calcified

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Page 21: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Umbilical Cord Aneurysm (UCA)

• Careful research for other anomalies• UV varix may be first manifestation of vein

pressure• Monitor impending hydrops• Monitor for anemia• Use color Doppler for checking

• D/D– Normal fluid-filled structures– Abdominal cysts (choledochal cyst, meconium

pseudocyst, ovarian cyst, urachal cyst)– UC cysts

Page 22: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Meconium pseudocyst

Page 23: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 24: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Vasa Previa

• Submembranous fetal vessels cross cervical os

• Doppler shows fixed fetal vessels overlying cx os

• From succenturiate lobe: most common etiology

• Best imagine tool: TVS + color Doppler + PW

• D/D– Marginal sinus previa– Cord presentation– Uterine vessel near cervix

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Page 28: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 29: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Vasa Previa

• Pathology: 1 in 3500 deliveries

• 60~80% fetal mortality if diagnosis missed.

• C/S before onset of labor

Page 30: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Nuchal Cord

• One or more complete loops of UC around fetal neck.– Males>females; 29% at 42wks– Single loop 10.6%, double 2.5%

• Diagnosis best by: Doppler US and 3D ultrasound• Recommendations~

– Look for vascular compromise (S/D ratio)– Fetal growth and movement, amniotic fluid

• D/D– Cord adjacent to neck– Cystic hygroma

Page 31: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
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Special Topic

Cord Index

Page 33: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

OBGYN 2006

Page 34: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 35: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

• Under coiling is associates with (umbilical coiling index below the 10th percentile)– fetal death– spontaneous preterm delivery– trisomies – low Apgar score at 5 minutes– velamentous cord insertion – single umbilical artery

Page 36: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

There was an inverse relationship between the umbilical coiling index and the birth weight percentile.

• Over coiling (umbilical coiling index above the 90th percentile) – asphyxia– umbilical arterial pH < 7.05 – small for gestational age infants – trisomies – single umbilical artery

Page 37: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 38: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

• Under-coiling may give way to kinking and compression, whereas over-coiling may give way to occlusion in cases with cord entanglement.

• Early second-trimester low umbilical coiling index predicts small-for-gestational-age fetuses.(J Ultrasound Med 20:1183–1188, 2001)

Page 39: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 40: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

It appears that umbilical cord coiling modulates noticeably blood flow through the umbilical cord.

We speculate that more prominent umbilicalcoiling (higher antenatal UCI values) has a protective effect on blood flow in terms of decreased arterial resistance and higher blood flow velocities, as well as increased venous blood flow.

Page 41: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Abnormal Cord Doppler & Clinical Significance

Page 42: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
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Page 50: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

叫我第一名

Page 51: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

The DV blood flow that was corrected for fetal weight was increased significantly in intrauterine growth-restricted fetuses compared with control fetuses (P=0).

In 23 of 30 IUGR, the percentage of umbilical blood flow that was shunted through the ductus was>90th percentile of control fetuses.

DV diameters were significantly greater in growth-restricted fetuses than in control fetuses (P=.0001).

Page 52: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
Page 53: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

• IVC, DV, and UV Doppler parameters correctly predict acid-base status in a significant proportion of IUGR neonates. Combination, rather than single vessel assessment provides the best predictive accuracy.

Page 54: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

We studied 97 gravidas with the diagnosis IUGR and confirmed 61 cases of IUGR with acidemia. The demographic data showed that 24 gravidas had a diagnosis of preeclampsia, and 37 had pregnancies superimposed with chronic hypertension.

Page 55: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Results

• Based on the PI of the umbilical artery and PI for the vein of the ductus venosus, the areas under the receiver operating characteristic curves were 0.7992 and 0.6749, respectively, for predicting growth-restricted neonates with acidemia.

• With a combination of the PIs of the umbilical artery and the PIs for the vein of the ductus venosus, the predictive accuracy of the growth-restricted neonates with acidemia increased, with sensitivity of 0.79 and specificity of 0.79 and an area under the receiver operating characteristic curve of 0.8441.

Page 56: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會
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Page 58: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Conclusions

• Compared with single-vessel assessment, combining the PIs of the umbilical artery and the PIs for the vein of the ductus venosus provides the greatest accuracy in predicting growth-restricted neonates with acidemia.

Page 59: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

•婦人生產的時候就憂愁,因為他的時候到了;既生了孩子,就不再記念那苦楚,因為歡喜世上生了一個人。

Page 60: Prenatal Diagnostic Ultrasound in Application of Umbilical Cord 台北榮總婦產部 陳志堯 洪正修主任指導 2006 年中華醫用超音波年會

Train up a child in the way he should go: and when he is old, he will not depart from it.

(Proverb 22:6)

Thanks for attention!Thanks for attention!