PROGRAM - APHAR Austrian Pharmacological SocietyA 3 Deferoxamine Administration Following Hypoxia-Ischemia in the Rat Brain: Neurotransmitter Concentrations and Histological Outcome

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LLooccaattiioonn

Institute of Pharmacology Nearest Underground station: Währinger Straße 13a, A-1090 Vienna Schottentor, line U2 (purple line)

RReeggiissttrraattiioonn FFeeeess aanndd OOrrggaanniissaattiioonn

Registration Fee: € 20.– (Please pay the registration fee at the registration desk) Reduced registration fee for retired members of APHAR and for students with written

confirmation of student status: € 10.– (The confirmation form can be downloaded from: http://www.aphar.at/2006/student.rtf and should be signed by the head of the institution)

Participation is free of charge for plenary speakers and for APHAR honorary members. Travel Grants: A limited number of travel grants are available for students of institutions outside Vienna

(€ 200 for western Austria, € 150 for eastern Austria). Please use the application form (http://www.aphar.at/2006/reko06.rtf) and return it by fax (+43-316-380-694310 or +43-316-380-9645). Grants will be awarded in the order of their arrival.

Registration Desk: Institute of Pharmacology, Medical University of Vienna Währinger Straße 13a, A-1090 Vienna, Tel: +43 (1) 4277-64101, Fax: +43 (1) 4277-9641 e-mail: [email protected]

Opening hours: Thu 23 Nov: 13:00 – 17:30 Fri 24 Nov: 08:30 – 18:00 Sat 25 Nov: 08:30 – 12:00

Language: All presentations shall be given in English. Organisation: Austrian Pharmacological Society (APHAR)

President: Ernst Singer, Institute of Pharmacology, Medical University of Vienna Tel: + 43 (1) 4277-64100, Fax: +43 (1) 4277-9641, [email protected] Secretary: Thomas Griesbacher, Inst. for Exp. and Clin. Pharmacology, Medical University of Graz Tel: +43 (316) 380-4310, Fax: +43 (316) 380-694310 or 380-9645, [email protected]

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AAuussttrriiaann SSoocciieettyy ooff TTooxxiiccoollooggyy ((AASSTTOOXX))

ASTOX Poster Session

13:30 The presenters of ASTOX posters are requested to be present at their poster during this session. The best ASTOX presentation (short communication or poster) will be selected to receive the Roche Prize (EUR 500), which will be awarded at the end of the Thursday afternoon ASTOX Symposium.

Chairs: Peter HEISTRACHER (Wien), Rolf SCHULTE-HERMANN (Wien)

Plenary Lecture

14:00 Inhibition of Histone Deacetylases by Valproic Acid: Interference with Embryogenesis and Cancer Development

Martin GÖTTLICHER (Institut für Pharmakologie und Toxikologie, Technische Universität München)

Short Communications

14:45 T 3

Upregulation of FGF-18 in Chemically Induced Rodent Hepatocarcinogenesis and in Human Hepatocellular Carcinoma

Tini Gauglhofer, S. Sagmeister, D. Macheiner, W. Parzefall, R. Schulte-Hermann, B. Grasl-Kraupp (Wien)

15:00 T 7

Hepatocarcinogenesis by Diethylnitrosamine (DEN) in NADPH Oxidase Knock-Out Mice and Their Wild-Type Counterparts

Constanze Freiler, A. Brink, W.K. Lutz, E. Kainzbauer, R. Schulte-Hermann, W. Parzefall (Wien, Würzburg)

15:15 T 6

Aquatic Ecotoxicity of Quaternary Ammonium Compounds Britta Grillitsch, N. Kreuzinger, O. Gans, V. Kucera-Hirzinger, C. Lesueur, M. Uhl, H. Zornig, H. Untersteiner, S. Scharf, M. Fuerhacker (Wien)

15:30 Coffee Break and Posters

Chairs: Martin GÖTTLICHER (München), Wolfram PARZEFALL (Wien)

Oral Communications

16:00 T 2

Isolated bc1 Complex as a Screening System for Potential Anti-Malaria Drugs Andrea Müllebner, T. Rosenau, A. Patel, L. Gille (Wien)

16:15 L 3

Antioxidant and Free Radical Scavenging Activities of Sumac (Rhus coriaria) and Identification of Gallic Acid as Its Active Principle

Franziska Ferk, A. Chakraborty, T. Simic, M. Kundi, S. Knasmüller (Wien)

16:30 L 5

Safety Assessment of Melanoidins in Cell Line Studies Karl-Heinz Wagner (Wien)

Plenary Lecture

16:45 Modulation of Mitochondrial Functions: Role of Reactive Oxygen Species Katrin STANIEK (Forschungsinstitut für Biochemische Pharmakologie und Molekulare Toxikologie, Veterinärmedizinische Universität Wien)

17:25 Presentation of the ROCHE Prize

17:30 Adjournment

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CClliinniiccaall SSeeccttiioonn ooff tthhee

AAuussttrriiaann PPhhaarrmmaaccoollooggiiccaall SSoocciieettyy ((AAPPHHAARR))

Chair: Brigitte BLÖCHL-DAUM (Wien)


09:00 K 10

Levels of Lipid-Based Amphotericin B in Epithelial Lining Fluid and in Human Monocytes Stefan Weiler, H. Vogelsinger, G. Falkensammer, R. Bellmann-Weiler, J. Kountchev, M. Joannidis, R. Bellmann (Innsbruck)

09:15 K 12

Inhibition of HIF-1α by RAD001 (Everolimus) in Combination with Antiangiogenic Chemotherapy in a Gastric Cancer Model

Daniel Cejka, M. Preusser, W. Sieghart, S. Strommer, J. Werzowa, T. Füreder, V. Wacheck (Wien)

09:30 K 4

Transcriptional Profiling of the Peripheral Blood Response after Statin Treatment and during Endotoxin-Induced Inflammation

Wolfgang M. Schmidt, A.O. Spiel, B. Jilma, M. Wolzt, M. Müller (Wien)

09:45 K 5

Exogenous Recombinant Human Cu,Zn Superoxide Dismutase Does Not Affect Vascular Dysfunction in Acute Inflammation

Georg Schaller, M. Felizeter, J. Pleiner, G. Gouya, N. Leuchten, F. Mittermayer, D. Haider, S. Kapiotis, B. Vcelar, M. Wolzt (Wien)

10:00 K 9

Novel Cholesterol Derivative for Selective Targeting of Gastric Cancer Thorsten Füreder, D. Cejka, B. Erovic, D. Thurnher, V. Wacheck (Wien)


10:45 K 7

Increased Temporal Lobe Efflux of R-[11C]Verapamil in Patients with Pharmacoresistant Epilepsy

Oliver Langer, M. Bauer, A. Hammers, R. Karch, E. Pataraia, M.J. Koepp, A. Abrahim, M. Brunner, R. Dudczak, K. Kletter, C. Baumgartner, M. Müller (Wien, Seibersdorf, London)

Plenary Lecture

11:00

Fat Forms the Body: The Pharmacological Actions of Adipocytokines Michael WOLZT (Univ.-Klinik f. Klinische Pharmakologie, Medizinische Universität Wien)

12:00 Mitgliederversammlung der Sektion Klinische Pharmakologie

Members of the APHAR Section of Clinical Pharmacology only

Teilnahmeberechtigt sind alle Mitglieder der Sektion Klinische Pharmakologie der APHAR. Gemäß § 12 der Statuten wird den Sektionsmitgliedern die vorläufige Tagesordnung spätestens vier Wochen vor der Sektionsversammlung zugeschickt. Gemäß § 3 der Geschäftsordnung der Sektion sind weitere Anträge zur Tagesordnung bis spätestens sieben Tage vor der Sektionsversammlung bei der Sektionsleitung schriftlich einzureichen.

12:30 Lunch Break

13:45 Generalversammlung der APHAR

Members of the APHAR only

Teilnahmeberechtigt sind alle ordentlichen Mitglieder, sowie Vertreter der außerordentlichen Mitglieder. Stimmberechtigt sind nur die ordentlichen Mitglieder. Gem. § 9 der Statuten wird den Mitgliedern die vorläufige Tagesordnung spätestens vier Wochen vor der Generalversammlung zugeschickt. Weitere Anträge sind mindestens sieben Tage vor dem Termin der Versammlung beim Vorstand schriftlich einzureichen..

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Chair: Steffen HERING (Wien)

15:00 L 8

Receptor G-Protein Coupling and the Cytoskeleton Christof Charalambous, J. Zezula, M. Freissmuth (Wien)

15:15 A 1

TRPC3 Contributes to VEGF-Induced Ca2+ Signalling in Somatic Endothelial Progenitor Cells Michael Poteser, A.E. Yates, H. Maechler, A. Graziani, M. Krenn, P. Eder, K. Groschner (Graz)

15:30 A 4

Evidence for Trapping of a Charged Phenylalkylamine in CaV1.2 Stanislav Beyl, A. Hohaus, A. Stary, M. Kudrnac, R.H. Guy, E.N. Timin, S. Hering (Wien, Bethesda)

15:45 A 8

Universal C-Terminal Modulation of Voltage and Ca2+-Dependent Gating in L-Type Ca2+ Channels

Anamika Singh, D. Hamedinger, J.C. Hoda, M. Gebhart, A. Koschak, C. Romanin, J. Striessnig (Innsbruck, Linz)


CURRENT TOPICS IN BRAIN DOPAMINE RESEARCH A t r i bu te to O leh Hornyk iew icz on the Occas ion o f h i s 80 t h B i r t hday

In cooperation with the Center for Brain Research (Vienna) and the Project Team Brain Research (Ministry for Education, Science and Culture). Participation free of charge

Chair: Christian PIFL (Wien)

16:30 Introduction

16:35

Marc G. CARON (Department of of Cell Biology, Duke University Medical Center, Durham, NC) Dopamine: From Pharmacology to Molecular Biology and Back

17:15

Patrick AEBISCHER (School of Life Sciences, École Polytechnique Fédérale de Lausanne) Viral vectors as a Tool to Model and Treat Parkinson's Disease

17:55

David J. BROOKS (MRC Clinical Sciences Ctr. & Div. Neuroscience, Imperial College London) Imaging the Role of Dopamine in Health and Disease

18:35 Concluding Remarks

18:45 Adjournment

Cocktail Reception at the Vienna Town Hall

19:30 Rathaus Stadtsenatssitzungssaal

(for map see page 9)

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Chairs: Christian NANOFF (Wien), Maria WALDHOER (Graz)

09:00 A 11

Visualizing the Membrane Mobility of Corticotropin-Releasing Factor Type 2 Receptors (CRF2-R) by Fluorescence Microscopy

Laura Milan-Lobo, D. Rüntzler, A. Bonci, M. Freissmuth, H.H. Sitte (Wien, Oakland)

09:15 A 12

Peptide-Based Interactions With Calnexin Target Misassembled GABA Transporter-1 Molecules into Organized Smooth Endoplasmic Reticulum Compartments

Volodymyr Korkhov, L. Milan-Lobo, H. Farhan, J.A. Schmid, M. Freissmuth, H.H. Sitte (Wien)

09:30 A 13

Xanthines Foster Up-Regulation of Export-Deficient Variants of the A1 Adenosine Receptor Laura Málaga-Diéguez, H. Pankevych, O. Kudlacek, C. Nanoff (Wien)

09:45 A 14

Retinoic Acid Induces Sensitization of Cyclic AMP Formation in a Neuroblastoma Cell Line Edin Ibrisimovic, L. Málaga-Diéguez, C. Nanoff (Wien)

10:00 A 15

Cdk6 – for the Better or Worse in Tumor Development? Karoline Kollmann, O. Simma, E. Zebedin, R.G. Ott, E. Weisz, V. Sexl (Wien)

10:15 A 5

STAT5 – A Novel Target for the Treatment of Abelson-Induced Leukemia? Wolfgang Warsch, A. Hoelbl, R. Kreibich, M. Kerenyi, R. Moriggl, V. Sexl (Wien)


Chair: Günther SPERK (Innsbruck)

11:00 A 17

Role of the Prostaglandin D2 Receptors, CRTH2 and DP, in Eosinophil Chemotaxis and Mobilization from Bone Marrow

Petra Schratl, J.F. Royer, E. Kostenis, E.M. Sturm, R. Schuligoi, I.Th. Lippe, B.A. Peskar, Á. Heinemann (Graz, Horsholm)

11:15 A 3

Deferoxamine Administration Following Hypoxia-Ischemia in the Rat Brain: Neurotransmitter Concentrations and Histological Outcome

Georgios Papazisis, D. Kouvelas, K. Kallaras, A. Kaiki-Astara, Ch. Pourzitaki, T. Dagklis, O. Guiba-Tziampiri (Thessaloniki)

11:30 A 2

Deletion of Y2 Receptors by Local Infusion of Adeno-Associated Virus (AAV) Vectors Expressing Cre-Recombinase in Y2lox/lox Mice and Subsequent Behavioural Testing

Ramon O. Tasan, S. Weger, R. Heilbronn, K.N. Nguyen, H. Herzog, N. Singewald, G. Sperk (Berlin, Innsbruck, Sydney)

HANS HORST MEYER AWARD 2006

11:45 The Hans Horst Meyer Award of the Austrian Pharmacological Society is awarded to young investigators in experimental and clinical pharmacology and toxicology. Donated by Pfizer Corporation Austria.

12:00

Ingrid GSANDTNER (Wien): Heterotrimeric G Protein-Independent Signaling of a G Protein-Coupled Receptor

12:15

Andrea HÖLBL (Wien): Clarifying the Role of Stat5 in Lymphoid Development and Abelson-Induced Transformation

12:30 End of meeting

H.H. MEYER 1853 – 1939

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PPoosstteerr PPrreesseennttaattiioonnss

Posters will be on display for the entire period of the meeting (Thursday afternoon till Saturday noon). Presenting authors are requested to indicate their presence at their poster on the poster board (preferably during coffee breaks).

Austrian Pharmacological Society (APHAR)

A 7 A Site of Interaction between the Selectivity Filter and the Inner Vestibule of the Voltage-Gated Na+ Channel

Touran Zarrabi, B. Latzenhofer, M. Mille, E. Zebedin, K. Hilber, H. Todt (Wien)

A 9 Duramycin Effects on hERG Potassium and Voltage-Gated Sodium Currents: A QT-Prolongation Risk?

Eva Zebedin, H. Pankevych, T. Zarrabi, B. Latzenhofer, M. Mille, H. Todt, M. Freissmuth, K. Hilber (Wien)

A 10 Brain Lesions in Aortic Denervated vs. Sham-Operated Rats Dimitrios Kouvelas, E. Amaniti, Ch. Pourzitaki, D. Kapoukranidou, J. Kalpidis, D. Vasilakos (Thessaloniki)

A 16 The Signaling Mute hCMV Chemokine Receptor US28R129A Prevents Melanoma Growth Hannes Seidl, H. Schaider, P. Quan, S. Frank, Z. Liu, M. Fukunaga, R. McDaid, H. Kerl, M. Herlyn, M. Waldhoer (Graz, Philadelphia)

APHAR Section of Clinical Pharmacology

K 1 No Immunomodulatory Effect of Fosfomycin in Experimental Endotoxemia in Humans Robert Sauermann, C. Marsik, I. Steiner, K. Seir, T. Cvitko, M. Zeitlinger, B. Jilma, C. Joukhadar (Wien)

K 2 Intravenous Administration of Clonidine Reduces Intraocular Pressure and Alters Ocular Blood Flow

Günther Weigert, H. Resch, A. Luksch, H.A. Reitsamer, G. Fuchsjäger-Mayrl, L. Schmetterer, G. Garhöfer (Wien)

K 3 The Effects of Short Term Statin Pre-Treatment and Subsequent Low Dose Endotoxemia on Circulating Endothelial Progenitor Cells in Healthy Volunteers

Alexander O. Spiel, F.B. Mayr, J.M. Leitner, C. Firbas, W. Sieghart, B. Jilma (Wien)

K 6 Effects of the Specific Interleukin-8 Inhibitor Reparixin on Endotoxin-Induced Inflammation Judith M. Leitner, F.B. Mayr, A.O. Spiel, B. Steinlechner, B. Jilma (Wien)

K 8 The Effects of Intravenous Histamine and Histamine Receptor Blockade on Ocular Blood Flow Katharina Karl, H. Resch, G. Weigert, L. Schmetterer, G. Garhöfer (Wien)

K 11 MicroPET Imaging with the β-Amyloid Probe [18F]FDDNP in a Transgenic Mouse Model of Alzheimer's Disease

Oliver Langer, C. Kuntner, T. Wanek, M. Bauer, M. Mandler, P. Angelberger, M. Müller, H. Kvaternik (Wien, Seibersdorf)

Posters should be fixed to the poster boards on Thursday and should be left on display until Saturday. Presenting authors are requested to indicate the times of their presence at the poster boards (preferably during the coffee breaks). Dimensions of the poster boards: width 90 cm, height 135 cm.

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Austrian Society of Toxicology (ASTOX)

The presenters of ASTOX posters are requested to be present at their poster at the ASTOX Poster Session (Thursday 23 Nov, 13:30–14:00). Please make sure that you put up your poster before the session starts. The best ASTOX presentation (short communication or poster) will be selected to receive the Roche Prize (EUR 500), which will be awarded at the end of the Thursday afternoon session. Posters should remain on display throughout the entire meeting (i.e. until Saturday noon).

T 1 Alkyl- and Aryl-Substituted Spin Traps: Free Radical Adduct Formation and Toxicity Studies Klaus Stolze, N. Rohr-Udilova, B. Marian, B. Grasl-Kraupp, H. Nohl (Wien)

T 4 Alterations of the Ras Pathway in Hepatocarcinogenesis: Species Comparison and Implications for Risk Assessment

Doris Macheiner, C. Rodgarkia-Dara, M. Grusch, H. Sutterlüty, W. Mikulits, H. Huber, R. Schulte-Hermann, B. Grasl-Kraupp (Wien)

T 5 Linoleic Acid Hydroperoxides and the Induction of Antiapoptotic Genes in Cultured Hepatocarcinoma Cells

Nataliya Rohr-Udilova, S. Sagmeister, K. Stolze, H. Nohl, R. Schulte-Hermann, B. Grasl-Kraupp (Wien)

T 8 The Fusarium Toxin Enniatin Exerts Cytotoxic Activities via Apotosis Induction Rita Dornetshuber, P. Heffeter, R. Kamyar, W. Berger, R. Lemmens-Gruber (Wien)

T 9 Impact of Staining Procedures on the Results of the Micronucleus Assay with Exfoliated Cells as Biomarkers for Human Cancer Risk

Armen Nersesyan, M. Kundi, K. Atefie, R. Schulte-Hermann, S. Knasmüller (Wien)

L 1 Hospital Waste Water: Health Risk for Human and Environment by Cytostatic Drug Emissions? Part I: Model Calculation and Chemical Monitoring

M. Fuerhacker, S.N. Mahnik, K. Lenz, N. Weissenbacher, R.M. Mader, P. Krenn, S. Hann, G. Koellensperger, M. Uhl, S. Knasmüller, F. Ferk, Wilfried Bursch (Wien)

L 2 Hospital Waste Water: Health Risk for Human and Environment by Cytostatic Drug Emissions? Part II: Biological Monitoring (Genotoxicity Assays) and Risk Assessment

F. Ferk, M. Uhl, M. Fuerhacker, S.N. Mahnik, K. Lenz, N. Weissenbacher, R.M. Mader, P. Krenn, S. Hann, G. Koellensperger, S. Knasmüller, Wilfried Bursch (Wien)

L 4 The Potential Antimutagenic and Antioxidant Effects of Maillard Reaction Products Used as "Natural Antibrowning" Agents

S. Reichhold, K. Koschtnig, Karl-Heinz Wagner (Wien)

L 6 Use of Human-Derived Cell Lines for the Investigation of Dietary Factors which Affect DNA Stability

Heike Winter, B. Grasl-Kraupp, R. Schulte-Hermann, M. Grusch, W. Mikulits, V. Ehrlich, S. Knasmüller (Wien)

L 7 DIMBOA and DIBOA, Two Naturally Occuring Benzoxazinoides, Cause Aneuploidy in a Human-Derived Liver Cell Line (HepG2)

Christoph Buchmann, A. Nersesyan, B. Kopp, D. Schauberger, F. Darroudi, T. Grummt, G. Krupitza, R. Schulte-Hermann, S. Knasmüller (Wien, Leiden, Bad Elster)

Posters should be fixed to the poster boards on Thursday and should be left on display until Saturday. Presenting authors are requested to indicate the times of their presence at the poster boards (preferably during the coffee breaks). Dimensions of the poster boards: width 90 cm, height 135 cm.

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COCKTAIL RECEPTION at the Vienna Town HalL

Date: Friday 24 November 2006

Time: 19:30

Location: Rathaus Stadtsenatssitzungssaal Eingang Lichtenfelsgasse Feststiege I

Admission on presentation of the invitation only (available from the meeting registration office)

Austrian Pharmacological Society (APHAR): Executive Committee:

President: Ernst Singer (Vienna), Vice-President: Michael Freissmuth (Vienna), Secretary Gen.: Thomas Griesbacher (Graz), Treasurer: Peter Placheta (Vienna), President of the Clinical Pharmacology Section: Brigitte Blöchl-Daum (Vienna), Further Member: Andrea Laslop (Vienna).

Clinical Pharmacology Section Committee: President: Brigitte Blöchl-Daum (Vienna), Vice-President: Kurt Krejcy (Vienna), Further Member: Bernd Jilma (Vienna).

ZVR-Zahl: 202359700 Website: http://www.aphar.at/

Suppor t i ng Members o f APHAR:

Stellvertretender Vorsitzender: Univ.-Prof. Dr. Michael Freißmuth (Wien); Vorsitzende der Sektion Klinische Pharmakologie: Univ.-Prof. Dr. Brigitte Blöchl-Daum (Wien); weiteres Vorstandsmitglied: Univ.-Prof. Dr. Andrea Laslop (Wien); Bankverbindung: Österreichische Postsparkasse, BLZ (Swift Code OPSKATWW), Kto.Nr. 920 551 59

Ö s t e r r e i c h i s c h e P h a r m a k o l o g i s c h e G e s e l l s c h a f t A u s t r i a n P h a r m a c o l o g i c a l S o c i e t y A P H A R

ZVR-Zahl: 202359700 Vorsitzender: Geschäftsführer: Kassier: Univ.-Prof. Dr. Ernst Singer Univ.-Prof. Dr. Thomas Griesbacher Univ.-Prof. Dr. Peter Placheta Institut für Pharmakologie Inst. f. Exp. u. Klin. Pharmakologie Boehringer Ingelheim Austria GmbH Medizinische Universität Wien Medizinische Universität Graz Dr. Boehringer-Gasse 5-11 Währinger Straße 13a Universitätsplatz 4 A-1121 Wien A-1090 Wien A-8010 Graz Tel. +43 (1) 80105-2251 Tel. +43 (1) 4277-64100 Tel. +43 (316) 380-4310 Fax +43 (1) 80105-2623 Fax +43 (1) 4277-9641 Fax +43 (316) 380-694310 [email protected] www.aphar.at [email protected] [email protected]

ANSUCHEN UM AUFNAHME

als ordentliches Mitglied ( Dissertant) (gem. § 5 der Statuten können alle Personen, die aktiv auf dem Gebiet der Pharmakologie in Forschung, Lehre oder Administration tätig sind und entweder ein abgeschlossenes Universitätsstudium besitzen oder sich im Dissertations-stadium befinden, Mitglieder der APHAR werden. Bei Dissertanten wird um Bestätigung des Institutsvorstandes gebeten.)

Mitgliedschaft in der Sektion Klinische Pharmakologie gewünscht: Ja

(gem. § 12 der Statuten können ordentliche Mitglieder der APHAR, die aktiv auf dem Gebiet der Klinischen Pharmakologie in Forschung, Lehre oder Administration tätig sind, Mitglieder der Sektion Klinische Pharmakologie werden.)

Nein

förderndes Mitglied

(mit *) gekennzeichnete Felder nicht auszufüllen bei Antrag um Aufnahme als förderndes Mitglied.)

*) Name: Zuname Vorname

*) Akad. Grad:

*) Berufstitel:

*) Ausbildung:

Derzeitiges Arbeitsgebiet:

Institut/Firma:

Anschrift:

Tel: Fax:

!! e-mail:

Datum: Unterschrift:

Befürwortendes Mitglied der Gesellschaft:

*) Name: Unterschrift:

Das ausgefüllte Formular bitte an den Geschäftsführer der APHAR (T. Griesbacher, Institut für Experimentelle und Klinische Pharmakologie, Universitätsplatz 4, 8010 Graz, Fax: 0316 / 380-694310 oder 380-9645) schicken.

Documents

PROGRAM - APHAR Austrian Pharmacological SocietyA 3 Deferoxamine Administration Following Hypoxia-Ischemia in the Rat Brain: Neurotransmitter Concentrations and Histological Outcome