29

q s q ->

  • Upload
    others

  • View
    5

  • Download
    0

Embed Size (px)

Citation preview

Page 1: q s q ->

� ����� ����� � ���������������� ��������� ����� ��!�"!���#�$�%�&��� ��')(+*,����,- . � /�10����, ��2

3547698;:=<9>@?�ACB;D9:=<9E&FHGJI1<9:=KCE&8;FLANMO47698;:=<9>@?�ACB;D9:=<9E&FHGP8;E�BRQS?UT9:=<PA�<WVYX Z�[�GP<\QC<9]PANM=:^<`_W8aQS?@:bB�E&<`_WQC<W6PBRM=E�ANFaE&FHG�BRMbA�F;Fdc;cae<W6PBRM=E�ANFaE&FHGPT\:^QSM=QC>C:bB&ANMPBRQS?@]969VRA�V;:^QS<fGS?@QCM=E�Bg69MbA�8%BRQS?@]96\VLA�V;:=QC<fGWB;D9E&?@:bB&ANMJBgQC?@]\69VLANVa:=QC<fhWX Z�[iBRQS?@]96\VLA�V;:=QC<Pjk l9m7n�oqprn5s7tWnruwv�l\x�nYy�zP{Hs7tWu|m7}�~

�C�S���J���S�r�@�d�9�����N�,�1�9��� ���N�O���H���C�S�&�P���f�����C�W������&� �d¡;¢C�S¢R£@�C¢H¤W¥a�S¢¦�9§g�%¨�©ª�N«b�­¬��P®#¯�°�±Y�N�­�W©��\«b�5²R���³�´�R²g�¦�5�R���W�µ|µ¶µ@¬·�C�r�^�`¬¹¸C¸`®�®�®��º�C»C²g�g�r²L�N�¹�a�R²R�W�5�R���H¸7¼ �P®7¯�°�¸����g�5���=�S�½©��¾À¿¶ÁàÄÀ¾¶ÅÆÂ

Ç ACBRV;E&8a:bA�E&?�]9M=Q�È�8aE&F;Va8a:bBRV;:=QC<ÉE&<9Ê�Ȧ?�E&F�V;QÆBR69V�QS8 °L�g�L��°&«5²g� XdZ1[ËA�V QS8�<9E�AN8�Fa]`E�BR: ÌJB�Í%QS8L_WF�:=<ÉA�69<9:bÎS69EÍ�AHÈ¦Ï Ð�A�<WÈ�8;E&FaV;8a:bBRV;:^QS<ÆE�<9Ê&ÈW?@E&F�BR6\V�VaD9E�V�Í�Q@FaV;8LAN<P_WF�QNÑÃ_WQC6\T9M=ERÒ½F;Va8RA�<P_WEH_ÉXdZ1[ÓANV$_Ô:­Õ�E&8;E&<WV�]PQSFa:=Va:=QS<9FYM=E�AHKW:=<9>Q�KCE�8aDPAN<9>CF�QNÑJF;:=<9>CM=ERÒ�FaV;8LA�<`_WE�_@X Z1[�Ï�4�Í�Q ]9:=E�BRE&F�QNÑÖX Z�[+?,AHÈ TPE�8;E5×RQS:^<\E�_�QC8 � «=»C�H�a�L� : ÑfVaD\E&:=8�VaE&8;?@:=<PANM¦Q�KSE&8aD`A�<9>SFA�8;E,BRQS?@]9M=E&?�E&<WVLAN8aÈWÏ�I�Fa:=<9> VaD\E&FaE�QC]`E&8RA�Va:=QS<9F�Ñr8LA�>S?@E&<WV;F�Q�ÑdX Z�[�h7QC8�QCM=:=>CQS<¦6`BRM=E&QCV;:Ø_ÔE&F�h�?,AHÈ�T`E�:=<9FaE&8;VaE�_ÀAN<P__WE&M=E&V;E�_ÙÑ58aQS?ËAUBR:=8LBR6\MØAN8Y]9:=E�BgE�QNÑO]9MbA�F;?@:b_@X Z1[�Ï9ÚÉE ]98;QC]`QCF;E�A�<�E&<PBgQÔ_Ô:^<\>UÑ5QS8�VaD9E�V;8LAN<9Fa:=Va:=QS<,VRA�T9M=E�QNÑ%A�4O6\8a:=<9>?,ASB;D9:=<9E�:=<ÆX Z�[ÛQCM=:=>CQS<W6PBRM=E&QCV;:b_WE&FdAN<P_ A,BgQC8a8;E&Fa]`QC<`_W:=<9>�FaE�8a:=E&F�QNÑ%8aE&F;Va8;:ØBgVa:=QC<9FUA�<`_�M=:^>WA�V;:^QS<9FYQNÑ%VaD\QCFaEUQSM=:^>SQC<W6WÒBRM=E&QSVa:b_WE&F�VaDPANV�hSÍ�D9E&<U]`E&8�ÑrQC8a?�E�_�QC<@Bg:^8RBR69MbA�8�XdZ1[ÜE&<PBgQÔ_Ô:^<\>�A�<U:=<9F;VLA�<WVRA�<9E&QS69F%_WE�FLBR8;:^]\Va:=QC<�Q�ÑfA 47698a:=<9> ?,ASB;D9:=<9EChFa:=?U69MbANVaE7VaD9E�QC]`E&8RA�Va:=QS<�Q�ÑPV;D9E�4O6\8a:=<9>Y?�ACB;D9:=<9E7E&<PBgQÔ_ÔE�_�:=<�VaD9QSFaE�QSM^:=>SQC<W6PBRM=E&QSVa:b_WE&FHÏfX Z�[|T`A�FaEH_�47698;:^<\>Y?,ASB;D9:=<9E&FDPAHKSEUTPE&E�<É]98aQS]PQSFaE�_ÝT¦È Þ�DPA�8;M^E�F Ç E�<9<9E&V;VUT969V�V;D9E&È :^<WKSQCßCE�:=?,AN>C:=<PA�8;È@E&<\Ê&ÈW?@E&F VaQà]PE&8´Ñ5QC8;?)VaD9EUF;VLA�V;ERá¦F;ÈW?UTPQSMVa8RA�<9F;:=Va:=QC<9FHÏÆâã698@AN]9]98aQWACB;D|_W: Õ�E&8aFU:=<ÉVaD`A�V�E&KCE&8;ÈÉQC]`E&8LANVa:=QC<ÀB&A�<¶TPE�]PE�8�Ñ5QS8a?@EH_ 69Fa:=<9>ÉBRQC?�?@E&8RBR:bA�M=M=È,AHKCAN:^MbANT9M=E8aE�FaVa8;:bBRVa:=QC<àE&<9Ê&ÈW?@E�FYA�<P_�M=:=>¦A�F;E&F�Ï

ä¦åæ ĶçÝè+éæÅÆÂ�ä\ç|å

4�D9E@BRQS<PBRE&]\V�QNÑdA@?�QCM=E�BR6\MØAN8dBRQS?@]96\VaE&8HhfÍ�D9QSFaE�TPA�F;:ØB�QS]PE�8LA�V;:=QC<9F�Í�QC6\MØ_àT`EU]PE&8´Ñ5QC8;?@E�_ÉB;D9E�?@:bB&A�M=M=È�:=<WÒFaV;E�AC_ÝQ�Ñ�E&M=E�BRV;8aQC<\:ØB�A�M=M=Ȧh�DPA�F!M^QS<9>�:=<¦V;8a:=>C6\E�_ 69F�Í�:=VaDÉV;D9EU]`QCFaF;:=T9:=M^:=V�È�QNÑÃF;VaQS8a:=<9>ÆAN<P_ ?,AN<9:=]969MbA�V;:^<\>U:^<ÔÑ5QC8;?,A�V;:=QC<A�V�_WE�<9Fa:=Va:=E&F :=?@]`QCF;Fa:=T9M=E VaQ�8aEHA�M=:=Ê&E�Í�:=V;DÆBR698;8aE&<WVUBRQC?�]969VaE�8aF�Ï�ê\QC8ã?,AN<¦È�ÈCE�AN8aFHhfV;D9E�F;E�A�8RB;D Ñ5QC8 A,B;D9E�?@:=FaV;8aÈ�8a:bB;DE&<9QS69>CDUV;Q�?�A�ßSE%A ?@QSM=E�BR69MbA�8�BRQS?@]96\VaE&8�D`A�F�T`E&E&<�AãÑ5Q9BR6\F�Q�ÑfQS698�ERÕ�QC8;VaF�VaQ!T969:=Mb_�V;D9E&?ÆÏ�47Q�?,AN<WȦh�VaD9E BaD\E&?@:=FaV;8aÈQ�Ñ�M^: Ñ5E!Í�:^V;D�:=VaF ?UÈW8a:bAC_�QNÑ%E&<9Ê&ÈW?�E&F�A�<P_à:=<WÑ5QC8;?,ANVa:=QC<PANM­M=È�8a:bB;DÆ<W6PBRM=E&:bB�ACBR:b_WF F;E&E&?@EH_ÆA�>CQWQ9_�B&AN<P_W:b_9ANVaERëìA�<`_�:=VDPANF%]98;Q�KW:Ø_ÔE�_U69F�Í�:=V;DUQC698�ÌP8;FaV�Fa6PB�BRE&FaFHÏYífANFaV�ÈCE�AN8�h9íÖE&QC<PAN8L_�[d_WM=E&?�A�<U69F;E�_�VaD9E BaD\E&?@:=FaV;8aÈUQNÑ#X Z�[æVaQ�F;QCM=KCEãVaD9E_W:=8aEHBRVaE�_�îãA�?@:=M=VaQS<9:bA�<�]`A�VaD�]98aQST9M=E&?ðï¹ñ@ò·ó�ôaÏ�4�D9:=F%Í�A�F�A KSE&8aÈ�:^?�]PQS8aVRA�<WV�ÌP8aF;V�FaVaE�]@VaQ�Í�A�8R_WF�8aE�ANM^:=Ê&:=<9>�?@QSM=E�BR69MbA�8BRQS?@]969VRA�V;:^QS<WëÜFa:=?U:=M^AN8%BRQC?UT\:^<`A�VaQS8a:bA�M�A�]\]98aQWACB;D9E&F ?,AHÈU]\8aQ�KCE�VaQUT`E�VaD9E�TPE�FaV ÍÃAHÈ�VaQ�FaQCM=KSE�ZYõæBRQC?�]9M=E&VaE ]98;QCTWÒM=E&?@FHÏ%eW6`BaD�AN<ÆA�]9]\8aQ¦ASB;DÙ_ÔQ¦E�FY<9QSV�h9D\Q�Í%E&KSE&8�h`>S:^KSE 69FYA �P°R�R»�°L�N©�©U�Cö��^� ?�QCM=E�BR6\MØAN8ÃBgQC?@]\69VaE&8�V;DPA�V B&A�<�F;QCM=KCE�A�<WÈ]98;QCT9M=E&?÷Ñ5QC8�Í�D9:bB;D�Í%E�B&AN<,Í�8;:=VaE�AUA�M=>CQS8a:=VaD\?ÆÏ

c�< QC8L_ÔE&8�VaQ�BRQS<9FaV;8a6PBgVªA�>CE&<9E�8LA�M�?@QSM=E�BR69MbA�8YBgQC?@]\69VaE&8 F;QC?@E�I�<9:=KCE�8aFLANM�?@Q9_WE�MOQNÑÃBRQS?@]969VRA�V;:^QS< 3 ���=»�� A_W:=>C:=VRA�MPBRQS?@]96\VaE&8HhW<9E&698RA�M�<9E&V�Í�QC8;ß�hC47698;:^<\>�?�ACB;D9:=<9ECh �g�a² Ϲj!?U69FaV�T`EYEgøÔ]\8aE&F;FaE�_�:=<�BaD\E&?@:=FaV;8aÈWÏOZ169?@E�8aQC6\F�Í%QS8aßSE&8aFDPAHKSEY]98;QC]`QCFaEH_UFa6`BaD�V;8LA�<\FaMbA�V;:^QS<9F�69Fa:=<9>�V;D9E&QS8aE&V;:ØB�A�MOB;D9E�?@:=FaV;8a:=E&F�Ï7Þ�DPAN8aM=E&F Ç E&<\<9E&VaV1ÌP8aF;V�M=:^ßSE&<9E�_�V;D9E QC]`E&8LANVa:=QC<�Q�Ñù Z1[i]`QCM=ÈW?@E&8RA�F;E�VaQ�AU47698a:=<9>U?�ACB;D9:=<9E :=<|ú�ûSüCý�ï¹þ!ÿ���ó�ôaÏãc�<|ú�û����àï þ!ÿ�����ô�D9E�>¦AHKSE�AUFRB;D9E&?,ANVa:bB�_WE�FLBR8;:^]\Va:=QC< Q�ÑA�XdZ1[ 47698a:=<9>�?�ACB;D9:=<9Eã69Fa:=<9>�:=?,A�>S:=<PA�8;È�E&<9Ê&ÈW?�E&FÃB�A�]PANT9M=EdQNÑO8;E�BRQC>S<9:=Ê&:=<9>@A�<`_@B;DPA�<\>C:=<9>�Fa:=<9>CM=EãTPA�F;E&FYQNÑOXdZ1[�ÏâãVaD9E�8aF�DPAHKSE�Fa:=<PBgEÉ]98aQS]PQSFaE�_+VaD9EÉBRQS<9FaV;8a6PBRV;:=QC< Q�ÑUBaD\E&?@:bB&ANMdBRQS?@]969V;E&8aF�69F;:=<9> _W: Õ�E&8aE�<¦V�F;E&VaF�QNÑ�DWÈW]PQSVaD9E&V;:bB&A�MB;D9E&?�:ØB�A�M�F;]PE�Bg:^E�F,A�<`_É_W: ÕJE&8;E&<WVU?@Q9_WE&M=F�QNÑdBRQC?�]969VRA�Va:=QS<fÏ�îf×RE�M^?�Ñ5E&M=V �R���N�­� ï���ôY_WE&FRBR8a:=T`E�VaD\E,BRQS<9FaV;8a6PBRV;:=QC<ÀQ�ÑB;D9E&?�:ØB�A�M9<9E�698LANM�<9E&V�Í�QC8aßWF�Í�D9:bB;DU:=<UVa698;<fhWVaD\E&È@]98;QC]`QCF;E�_�hW?@:=>SD¦V7T`EY69F;E�_�VaQ�?�A�ßSE�QCVaD\E&8%>SE&<9E&8RA�MfBRQS?@]96\VaE&8;F%M=:=ßCE47698a:=<9>ã?,ASBaD\:^<\E&F�Ï7Ð�Q9_WE&M=F7M=:^ßSE%V;D9E&F;EYVaD`A�V�_WE&VRA�:=M9D9Q�ÍÀAdBgQC?@]\69VLANVa:=QC< Í�QC69Mb_!]98aQ9BRE&EH_U: ÑPÍ�E�DPAC_�BRE&8;VLA�:=<@B;D9E&?�:bB&A�M=FA�V�QS698Y_W:=Fa]`QCFRA�M�]98;QCTPANT9M=ÈU?U69FaV�AHÍ�A�:=V%T\8aE�ANߦV;D98aQS69>CD\FY:=<@]98;QCV;E&:=<,E�<9>C:=<9E&E�8a:=<9>UVaQUT`E�:=?@]\M^E�?UE&<WVaE�_�Ï

ø9VaE�<9Fa:=QC<\F�Q�Ñf[d_ÔM^E�?,A�<�� F�AN]9]98aQWACB;D�3Rï¹ñ@ò��Sôah�ï¹þ����`ô5j ²R��� :=?@]9M=E&?�E&<WVf69<9:=KSE&8aFRA�M�?@Q9_WE�M^F·Q�ÑOBRQS?@]969VRA�V;:^QS<fÏ[d_ÔM^E�?,A�< ï¹ñ@ò��Sô�]98;E&FaE�<¦V;FÆAÉF;E&8a:=E&FàQ�Ñ�QS]PE&8RA�V;:^QS<ÜQC<��LX Z�[ VaE&F;V,V;69T`E&F��ÜV;DPA�V�Fa:=?U69MbA�V;E�AÉ?@E�?@QC8;ÈÉ?@Q9_WE&MãQ�ÑBRQS?@]969VRA�V;:^QS<fÏ Ç QC<9E�D �g�Ã�N�­� >S:=KCEdA!?@E�VaD9Q9_�ÑrQC8�Fa:=?U69MbA�V;:^<\>Y<9QS<P_WE&V;E&8a?�:^<\:^F;Va:bB�T`QWQCM=E�AN<,BR:=8LBg69:=VaF�Ï·c�<@T`QCV;D,QNÑOV;D9E&FaEFLB;D9E�?@E&FUE�ASB;D 8;E�ACBgVa:=QC<¶]PE&8´Ñ5QC8;?@E�_¶BRQC8;8aE&F;]PQS<P_WF�VaQÉAàFaVLANVaE&?�E&<WV�:=<ÀAÆBRQS?@]96\VaE&8�]98aQS>C8RA�?)QC8@AN<|E&M=E&?�E&<WV�QNÑdA

ú

Page 2: q s q ->

BR:=8LBg69:=V�Ï74�D9:=F�?@E�AN<9F�VaD`A�V�VaD9E �a]98;QC>C8RA�? �YÑrQC8�VaD9E&F;E�BRQC?�]969VaE�8aF�:^F�ACBgVa6PANM^M=È�ERø9E�BR69V;E�_�TWÈUVaD9E BaD\E&?@:=FaVHÏ � I�<\:^KSE&8aFRA�M]98;QC>C8RA�?�FYB&A�< TPE!Í�8a:=VaV;E&<�ÑrQC8YV;D9E&F;EU?@Q9_WE&M=F�T969V :=VY:=FãFa69F;]PE�BgVaE�_ V;DPA�V VaD\E&È�Í�QC69Mb_�TPE�MbA�8;>CE�AN<P_�8aEHÎC6\:^8;EªA�MbA�8a>SE<W69?UT`E&8%QNÑ#_W:=F;Va:=<PBRVãFaVaE�]9FYV;QUTPE :=?@]9M=E&?�E&<WVaE�_ÖÏ

c�<ÜV;D9:=F@]PAN]PE&8�Í�E�]98;E&FaE&<WV�AÉ?�E&VaD\QÔ_ÝÑ5QS8@E&<`BRQ9_W:=<9>|V;D9E�Va8RA�<9F;:=Va:=QC<ÜVRA�T9M=E�QNÑ�AÉ47698a:=<9>É?�ACB;D9:=<9E�Í�:^V;DQCM=:=>CQS<W6PBRM=E&QCV;:b_WE&F�h�8aE�]98aE&F;E&<WVa:=<9>ÀA�47698a:=<9>�VRA�]`ECh�D\E�AC_Ý]PQSFa:=Va:=QC<�h�A�<P_ F;VLA�V;ECh%ANFªAàFa:=<9>SM=EU?@QCM=E�Bg69M=EUQ�ÑdX Z�[�hOAN<P_ERÕ�E�BRV;:^<\>ÆV;8LA�<\Fa:=Va:=QC<\Fd6\Fa:=<9>�8;E&FaV;8a:bBRVa:=QS<|E&<9Ê�Ȧ?�EªB;D9E�?@:=FaV;8aÈWÏU[�VaQSVLANM�Q�Ñ���_W:=FaV;:=<PBRV�B;D9E&?�:bB&A�M7FaV;E&]9FUA�8;EU8aE&]`E�A�V;E�_VaQàFa:=?U69MbA�V;E$AÙ>C:=KCE&< 47698a:=<9>�?�ACB;D9:=<9ECÏ�[YM=M�QNÑÃV;D9EU8aEHA�>CE�<¦V;F�6\FaE�_Ý:^< VaD\:^F!E&<PBRQ9_W:=<9>ÆAN8aE@BRQS?@?�E&8LBR:bANM^M=È@AHKCAN:^MbANT9M=E3�� �&®+¨%�W»��^�N�P����«5���=�Cög� jYA�<`_�A�M=MfQNÑ%VaD\EªB;D9E&?�:bB&A�M�QS]PE&8RA�V;:^QS<9F�A�8;E�8aQS69Va:=<9E&M=È�]`E&8�Ñ5QS8a?�E�_�TWÈ�?@QCM=E�Bg69MbA�8�T9:=QCM=QS>C:=FaV;F�ÏI�F;:=<9>�VaD9:=F ?@E&V;D9Q9_�A�I�<9:=KSE&8aFRA�M�47698;:^<\>@?,ASB;D9:=<9EU3½B�A�]PANT9M=E�QNÑÃF;:^?U6\MØANVa:=<9>UA�<WÈ�47698;:^<\>@?,ASB;D9:=<9E�A�<`_�D9E�<PBRE@A�<WÈA�M=>SQC8a:=V;D9?,j7B&AN<,T`E�BRQS<9FaV;8a6PBgVaE�_�Ï

4�D9:=FY]`A�]`E&8Y:=<PBRM=6P_ÔE&F���A�8aE�K¦:=E&Í QNÑ�VaD9E�47698;:=<9>U?,ASBaD\:^<\EYÑrQC8a?�A�M=:=Fa?�GCA�8;E&KW:=E&ÍiQNÑ#V;D9E�F;Va8a6`BRVa698;E�QNÑ%XdZ1[�GVaD\E�QS]PE&8RA�V;:^QS<�Q�Ñ%8;E&FaV;8a:bBRVa:=QS<�E&<9Ê&ÈW?�E&FYQS<ÆX Z�[�G�A�FRBaD\E&?,ANVa:bB E&<PBgQÔ_Ô:^<\>@Q�Ñ�V;D9E�V;D98aE�E�F;VLA�V;E Ç 69FaÈ Ç E�AHKSE&8 4O6\8a:=<9>?,ASB;D9:=<9ECG9V;D9EUVa8RA�<9F;MbA�Va:=QS<,QNÑ%VaD\:^F FRBaD\E&?,ANVa:bB :=<WVaQ@8;E�A�M78;E&FaV;8a:bBRVa:=QS<ÆE&<\Ê&ÈW?@E&F�A�<`_�QCM=:=>CQS<¦6`BRM=E&QCV;:Ø_ÔE&F�G�A@_ÔE&FLBR8;:=]9Va:=QC<Q�Ñ7:=VaF�ERø9VaE�<9Fa:=QC<àVaQUAUI�<9:=KCE�8LA�M�47698;:=<9>�?�ACB;D9:=<9ECG9AN<P_@AU_Ô:^FRBR69F;Fa:=QC<�QC<�V;D9E ]98LASBRVa:bB&ANM^:=V�È�Q�ÑOV;D9:=FYA�]9]\8aQ¦ASB;DfÏ

 éÜĶä¦å� ��¾¶Å��ÜäWå��àÁ

����� ������������� �"!#�%$'&�(*),+-)/.��%0[Û47698a:=<9>�?,ASB;D9:=<9E@ï21�3Öô%:=F�A ©U�H�C���%�54@²R��©ã�P�S�a�H��«5��� ë+A�Í�AHÈ�Q�Ñ�8aE&]98;E&FaE�<¦V;:=<9>�AN<P_à]PE&8´Ñ5QC8;?@:=<9>�AU>C:=KSE&<

BRQS?@]969VRA�V;:^QS<fÏ 4O6\8a:=<9>É?,ASB;D9:=<9E&F,AN8aE ?,ANVaD9E&?�A�V;:ØB�A�M=M=ÈÆE�ÎS69:=KCANM^E�<¦V�VaQÀ?,AN<WÈÉQCVaD\E&8�?@Q9_WE�M^FUQNѪBRQS?@]969VRA�V;:^QS<WëBRE&M=M=69MbA�8 A�69V;QC?�A�VLA�ï26�7 ��òWôah`<9E&6\8LA�M7<9E�V�Í%QS8aßWFUï98#7 ôah�A�<P_�_Ô:^>S:=VLA�M7BRQC?�]969V;E&8aF�ï �\ôaÏ Ç EHB&A�69F;EU<9QC<\E�QNÑ#V;D9E&F;EU?@Q9_WE&M=FQ�Ñ�BRQC?�]969VLANVa:=QC< 3rQC8�A�<WÈ�QCV;D9E&8 Í%E�DPAHKSE Ñ5QC6\<P_9jã:=FY?@QS8aE�]`Q�Í�E&8�Ñ56\MOV;DPA�<àVaD9EU47698;:^<\>U?,ACB;D9:=<9E!?@Q9_WE&M�Í%E�TPE�M^:=E&KSEVaD`A�V�47698;:^<\>�?,ASBaD\:^<\E&F7E&?UTPQ9_WÈ!Í�DPA�V�Í%E�?�E�A�<�Í�D9E&<�Í%EãFLAHÈ�FaQS?@E&V;D9:=<9> :^F ²L�N©Y�`�S�´�Sö&�=� 3�Þ�DW698LB;D � F�4�D9E&Fa:=FHÏ j!4�DPANV:=F�hfAN<WȦV;D9:=<9>UÑrQC8 Í�D9:bB;DÆÍ�E@B&A�< Í�8a:=V;EªA�]98;QÔBgE�_W698;ECh7QC8�A�< ���³»N�N°&«=�r�¦© hfB&AN<ÆT`E@BRQC?�]969V;E�_�TWÈÆA�47698a:=<9>�?,ASB;D9:=<9ECÏÇ E�B&A�6\FaE�Q�ÑO:=V;F�Fa:=?@]9M=:bBR:=V�ÈUA�<P_�E�ÎS69:=KCA�M=E&<`BRE VaQUQCV;D9E&8ã?@Q9_WE&M=F�Q�Ñ#BgQC?@]\69VLANVa:=QC<fhS[YMbAN<@47698a:=<9>�� F%?�QÔ_ÔE&M�DPA�FYANM=M^Q�Í�E�_69F�VaQ�]\8aQ�KCEU?�A�<WÈ�:=?@]`QC8;VLAN<¦V 8;E&Fa69M=V;FªANTPQS69V�VaD\E@<PANVa698;EÙAN<P_ M=:=?@:=VaFãQ�ÑdBRQS?@]969VRA�V;:^QS<É3 ���=»�� VaD9E�69<P_WE�Bg:Ø_\A�T9:=M=:=V�ÈQ�Ñ�VaD\E�DPANM=Va:=<9>@]\8aQCT\M^E�?Æh�A�<P_àVaD\EUERø9:^F;VaE&<`BRE@QNÑ%69<PBRQS?@]96\VLA�T\M^E$Ñ569<PBRV;:=QC<9FHÏ jÝ[ËBRQS8a8aE�Fa]`QC<P_WE�<PBRE�TPE�V�Í%E&E�<|A,X Z1[BRQS?@]969V;E&8�A�<P_�47698;:=<9> � F7?@Q9_WE&MW]96\VaF%X Z�[æBRQC?�]969VLANVa:=QC<!QC<�E�ÎS6PA�M\Ñ5QWQCV;:^<\>YÍ�:=VaD �N�/: QCVaD\E&8�?@Q9_WE�M9Q�ÑfBRQC?�]969VRA�Va:=QS<A�<`_,ANM=M^Q�Í�F·:^V�V;QU:=?@]9M=E&?UE&<WV �N�/: A�M=>CQS8a:=VaD9? Ï

���<; ¾=0>.�0��?��@/$'+ �A�B���C!#@/.�&�)/.���0D� ��ÂE(B@/.�0BFG$'+ !/HB.�0��-�[�FRBaD\E&?,ANVa:bB�8;E&]98;E&FaE&<WVRA�Va:=QS<|Q�ÑYA�47698a:=<9>�?,ASB;D9:=<9EU354YÐàj QC]`E&8LANVa:=<9>�QC<É:=V;FdVRA�]`EU:=F�>C:=KCE�<Æ:=<Éêf:=>S698aE�úSÏ

4�D9E�VRA�]`E�B&AN<�TPE!VaD9QS69>CDWVYQNÑ%A�FdA�F;E�ÎS69E&<PBgEUQ�Ñ�?@E&?�QC8;È ²R���b�¹� ERø9VaE&<P_Ô:^<\>@:=<P_WERÌ`<9:=VaE&M=È/I :=<�TPQSVaDÆ_W:=8;E�BRVa:=QS<9F�Ï ACB;DBRE&M=MfB&AN<@F;VaQC8;E�A�F;:^<\>CM=EYF;Ȧ?UT`QCMÔÑ58aQS?ÓV;D9E FaE&VYe�JLK�FNMChWF � hPO�OQO&hSF�RTS¦Ï74�D\EY47698a:=<9>!?,ACB;D9:=<9E�D`A�F�V�Í%Q�]PA�8;VaFQ��A �9�L�S� hA�<`_,AVU �9«=�a�U²L�N�W��°L��� Ï�4�D9E!D9E�AC_Ù]PQS:^<WV;F�VaQUQC<\E�BRE&M=MfQNÑ�VaD9E�VRA�]`E�A�<`_@?�AHÈU8aE�AS_�A�FaÈW?UT`QCM\Ñ58aQS?ËV;DPA�V BRE&M=M�h9Í�8;:^V;E�AFaÈW?UT`QCMWVaQ�VaD`A�V%BRE�M^M�hSQC8�?�Q�KCE�8a:=>CDWV�QS8�M=ERÑ5V�V;Q�A�<@AS_&×&ASBRE&<WVÃBgE&M=M½Ï�[�V�E�ACB;DUVa:=?�E&FaV;E&]U:=<UVaD9EãQC]`E&8LANVa:=QC<UQNÑfVaD9Eã4O6\8a:=<9>?,ASB;D9:=<9E VaD9E�D9E�AS_�]`E&8�ÑrQC8a?�FdA�BRQC?�]PQS69<P_�QS]PE&8RA�V;:^QS<ÆBRQS?@]`QCFaEH_�Q�ÑÃA�Fa:=<9>SM^E�8aEHAC_�h`Í�8a:=V;EChfA�<`_�?�Q�KCECÏ�4�D\E�ÌP<\:^V;EBRQS<¦V;8aQSM­ëÜV;D9E �aT\8LA�:=< ��Q�Ñ%V;D9E�4O6\8a:=<9>@?�ACB;D9:=<9ERëì_W:=8;E�BRVaFãVaD9E�D9E�AS_�Ï [ÛFa]`E�BR:bA�M�BRE�M^M·:^<àVaD9E!ÌP<9:=VaEUBRQS<¦V;8aQSM#BgQC<WVLAN:^<\FVaD\E �R�a�H�a� QNÑ#V;D9E�?,ACB;D9:=<9ESh9AU?@E�?UTPE&8�Q�Ñ�VaD9E�FaE&VAWXJYK�ÎCM�h OQO�O&h`Î[Z�S¦Ï�4�D\E�8;E&FaV Q�Ñ�VaD9E Ì`<9:=VaE�BRQS<WVa8aQSM7D9QC69F;E&F VaD9E��°L���Ô�g«Ø�½«5�N���´�Sö&�=� Í�D9:bB;DÙ_ÔERÌP<9E&FãD9Q�ÍæVaD9E Ì`<9:=VaE�BRQC<WV;8aQCM�Í�:=M=M�:=<9FaV;8a6PBgVYVaD\EdD\E�AC_�Í�D\E&<�VaD9E�D\E�AC_�]`QC:=<WVaF�VaQ@A!>C:=KSE&<FaÈW?UT`QCM`F�\UA�<P_�V;D9EãÌP<9:=VaE�BRQS<¦V;8aQSMf:=F�:=<,A�>C:=KSE&<@F;VLA�V;E�Î[]PÏ

ê\QC8�E&KSE&8aÈ�]PQSFaF;:^T\M^Eã]PA�:=8�3rF�\9hWÎ[]¦j·VaD9EãVa8LAN<9Fa:=V;:^QS<UVLANT9M=EY>C:=KSE&F%A!Va8a:=]9M=E 3rF�^YhWÎ[_9hC?�jfÍ�D\E&8aE F�^É:=F�VaD9EãFaÈW?UT`QCMÍ�8a:=V;VaE&<�TWÈ@V;D9E D9E�AC_ÖhPÎ[_�:=F�VaD9E!<9E&ÍæFaVLANVaE ÑrQC8�VaD9E�?�ACB;D9:=<9EChWA�<`_U? :^F�VaD\E�?@Q�KSE&?@E&<WV7?,AS_WEYTWÈUV;D9E�D9E�AS_Sëìí�h ù hQC8�î!h`Ñ5QC8ãM=ERÑ5V�hÖ8a:=>CDWV�h�A�<P_àDPA�M=VHh�8aE&F;]PEHBRVa:=KCE�M^ÈWÏ�crÑÃ?`J î VaD9EU?�ACB;D9:=<9E E&<WVaE�8aF�VaD9E@A�Fa]`E�BR:bA�M�FaVRA�VaE@Î M hÖߦ<\Q�Í�<�ANFVaD\E �Ô�N�¹��«b�W» FaVRA�VaEShJAN<P_UV;D9E�BRQS?@]96\VLA�V;:=QC<UFaV;QC]9FHÏ�4�D9:=FYANM^M=Q�Í�F�6\FYVaQ�M=E�AHKCE�Î M QS69V%QNÑ�VaD9E Fa]`E�BR: ÌJB�A�Va:=QS<�Q�Ñ�A�4O6\8a:=<9>acbed�f gCh�i?gkj%dkl m?h�d/i-noh�h<p�nqlNr/stlNuvdwsth�gxh/y�lQz{h5p9gCuPlNrk|%}~j�gw�2y��{p9i?de�2�tm#dwsth5y�i?dCstlNy�h��?�e�tgxd/uPrx�9dkh#lN�tdCdwsth#��lN�{dxh5�{dkgClNntj?lc�{r,��lNy��{�tdxh5rNf g

y�h5y�lcr�j#lN� p2�9dxdep9h�gep2�2�tg[lNn��tic��h5rtic�tz��{�tgws�desth<y�iNr�lc�{�tz�i?����lNr5zQ�2�tm/dxl#i#�{r5l?mNr5iNyA�{�Psth/p2�9dxdep9h�gep2�2�tg[lNn?�tiN�Ch5r��Q�C�Ch5rxnolNrxy�i���lNy��{�tdxi?de�9lc���}{�td�dwsth�j*stiNr5zQp9j�h��?lN|Qh�desth��2y�i?m?h lNn#i���lNy��{�tdxh5r�dwsti?d�uPh�iNr�h�noiNy��2p2�9iNr�uP�9dws{��lN�th�lcn/�{r�l�mNr�icy�y��2�tm�i���lNy��{�tdxh5rN��dwj?�{�2�tm��N�?�{�{iN�tzuPi?dk�xs{�2�tmP�9dCm?l����-h��?h<r�dwsth5p9h�gkg��5���-�vy�h<y�lNr�jPy�lQz{h5p9g�stiN�?h�i r�h�iNp�i?z{�NiN�{dxi?m?hClN�?h5r[�tiN��h<rt�{�tgws{�2�tm#��lNy��{�tdxh5r5g{iN�tzC�5�Ch5rxstiN�tg��5h<p9h���dwr5lN�{�9�lN�th�ge��dwsth�j�iNp2p9lNu��tg�dxl��{�tgws¡icr�lN�{�tzV¢N£ ax¤ p2�9dkdwp9h �{�9h���h�g#lcn�� �����tiN�Ch5r�i?d-lN�t��h�¥�¦ob§�©¨ ªB«#¬�­�®�¯A¢N£ ax¤ ���-��y�lNp9h��<�{p9h�gPiNr5h �tgkh�zVdklr5h5�{r5h�gxh5�{d/h�z{m?h�g/�2�Ai�mNr5iN�{s/� °±Q²5³ ��´¶µ ³{·9¸ ´5¹ ºN�Q�2�»dws{�9g#��lN�{dkh�¯�d���y�h�iN�tgPdesti�dP�2n,h��?h5r�lc�{r��[�{rx�2�tm�y�i?�xs{�2�thPrx�{�tg#lN�td#lNn/dxiN��h-u�h%iN�{��h<�tz�i�nqh�u�y�lNr5h���h<p2p9g��

Page 3: q s q ->

q1

s2

s1

s3

s4

s5

s6

s3

s1

s2

s2

s4

s5

s1

s2

q1

q1

->

->

s6

s2

s4q2

q3

. . .

L

R

Transition Table

Current State

Tape

Finite Control

Head

ê�:=>C698;Eªú[�747698a:=<9>�?,ASBaD\:^<\E�?@Q9_WE&M�QNÑ#BRQS?@]969VRA�V;:^QS<fÏ

?,ASB;D9:=<9EYA�<P_�BRQC<\Fa:b_WE&8�QS<9M=È�V;D9E <9QC<WÒ�DPANM^V;:=<9> FaVLANVaE&FHÏ�c�<P_ÔE&E�_�Í�D9E&<�Í�EYFaVRA�V;EdV;D9E �&« � � QNÑOA�4YÐ Í%E B&A�M=M�A�?�ACB;D9:=<9EÍ�:=VaD���F;Ȧ?UT`QCM=F%AN<P_�� �P���W¥��9���³�½«b�Ô» F;VLA�V;E&FdA��!ø���4YÐÉÏc�<9F;VaE�AS_�Q�Ñ�_W:=K¦:b_W:=<9>!VaD9E 47698a:=<9>�?@Q9_WE�M�Q�Ñ#BgQC?@]\69VLANVa:=QC<U:=<WVaQ �aDPAN8L_WÍ�A�8;E �@A�<`_ �;?,AN>C<9E&V;:bB�?@E�_W:bA ��A�F�Í�E

_WQ�Í�D9E&<�Í�E�>C8;QC69]àVaD9E�D9E�AS_�h`VaD9E�V;8LAN<9Fa:=Va:=QS<�VLANT9M=EChPAN<P_�VaD\E�F;VLA�V;E�QNÑ�VaD9E Ì`<9:=VaEUBRQC<WVa8;QCM�VaQC>SE&VaD\E&8�A�FYV;D9E�4O6\8a:=<9>?,ASB;D9:=<9E@A�<P_¶]9MbASBRE�VaD9E�VLAN]PE�TWÈ|:=V;FaE&M ÑLh·Í%E�?@:=>SD¦V >S8aQC6\] V;D9E&F;E�E&M=E&?@E�<¦V;FUQ�Ñ VaD9E�?@Q9_WE�MÃANM^QS<9>É_W: ÕJE&8;E&<WV@M=:=<9E&FQ�BRQS<9FaVRA�<WV�E&M=E&?�E&<WVaF�AN<P_ KCA�8;:ØANT9M=E�QS<9E&FHÏ�4�D9EUKCA�8;:ØANT9M=E�E�M^E�?@E&<WVaF QNÑYVaD9EU?�QÔ_ÔE&M�h�VaD9E�D9E�AS_ ]PQSFa:=Va:=QC<�h�VaD9E�FaVRA�VaE�Q�ÑVaD\E�ÌP<\:^V;E�BRQS<¦V;8aQSM½h�AN<P_�VaD\EªBRQS<WVaE&<WVaF QNÑ%VaD9E�VLAN]PEUA�8;ECh`VLANßCE&< VaQS>CE&V;D9E&8�hÖߦ<\Q�Í�<ÙANF�A�< «b�Ô�L�a���Ô�´�N�P�R���S���S�R��²�°&«¹�\�½«5�N�QC8�� Q�Ñ%A�4O6\8a:=<9>@?�ACB;D9:=<9ECÏ14�D9E�8;E&?,AN:=<9:=<9>�]`A�8aVãQ�Ñ%V;D9E�?@Q9_WE&M�hWVaD\E�V;8LA�<\Fa:=Va:=QC<àVLA�T\M^EShP:=F BRQC<9F;VLAN<¦V�AN<P_�Í�EªB&ANM=M:=V�VaD9E ©ª�S²R�W«b�P� ]PA�8;VYQ�Ñ�V;D9E�?@Q9_WE�M½Ï74�D\E�47698a:=<9>�?,ASBaD\:^<\Ed?�Q9_WE&M�h¦_Ô:^KW:b_WE�_�:=<�VaD9:=FãÍÃAHÈWh9A�M=M=Q�Í�F%6\FYVaQU]\:ØBgVa698;E�VaD9E?,ASB;D9:=<9EYA�FYAN< �R�9��°L�H�a��° V;DPA�VYASBRVaF�QS<,AN<@caX A�V�Va:=?�E�4 AN<P_U]98;Q9_W6PBRE&F A�<\E&ÍìcaX ANV%V;:=?@E�4���ú�ï¹ñ� fôaÏ�4�D9:=F%:=F�VaD9E:=?,AN>CE�Q�Ñ�A�47698a:=<9>�?,ASBaD\:^<\E�VaDPANV�>C69:b_WE&F�V;D9E�X Z�[ :=?�]9M=E&?UE&<WVLANVa:=QC<�Q�Ñ74O6\8a:=<9>�?,ACB;D9:=<9E�F%>S:^KSE&<�:=<@VaD\:^F�]`A�]`E&8�Ï

����� ¾=0>����+ $'&B������Á .�$G(���+-),.���0'� ��+ � �t)/+-)/�ì¿�(B��� ¿��-+�� ��@ $'+ !/H�.�0��4�D9E�47698a:=<9>�?,ACB;D9:=<9E!Í%E�FaD9Q�Í D9E&8;EU:^F A�FaQCM=69V;:=QC<�V;Q,V;D9E�Í%E&M=M7ßW<9Q�Í�< Ç 69FaÈ Ç E�AHKCE&8!]98aQST9M=E&? Ñ5QC8 V;D98aE&E

FaVRA�V;E@47698a:=<9>�?�ACB;D9:=<9E&FHÏ � 4�D\:^F Ç 69FaÈ Ç E�AHKSE&8�?�ACB;D9:=<9E�3 Ç�Ç ÒaýCj$DPA�F�AÙV�Í%Q�FaÈW?UT`QCM�A�M=]9D`A�T`E&V�e�J K Ç hfÚ S@AN<P_VaD\8aE&E�3r<9QC<WÒ�DPANM^V;:=<9>¦j1FaVLANVaE&FHh�W'J K�Î � h¹Î I h¹Î � S¦Ï�4�D9E�Va8LAN<9Fa:=V;:^QS<ÆVRA�T9M=E!Ñ5QC8 V;D9EU?,ASBaD\:^<\E�:=Fd>S:=KCE&< :=<ÆB&A�8;VaQWQC< ÑrQC8a?:=<�êf:=>S698aE �\Ï�4�D9E�F;ÈW?UTPQSM^F Ç A�<P_�Ú AN8aE�8;E&]98aE�FaE&<WVaEH_ÉTWÈ@T9MbASBaß�AN<P_�Í�D9:=VaE�T`QHø9E&F�ÏYeÔ?,A�M=M=E&8�TPQHø9E&FHh`8aE&]98;E&FaE�<¦V;:=<9>VaD\E�FaVRA�VaE�FdÎ � h9Î I h9A�<P_�Î � DPAHKSE TPE&E�<ÆA�F;Fa:=>C<9EH_�VaD98;E&E�F;DPAC_WE�FYQ�Ñ�>S8LAHÈWÏf[ ?@Q�KCE�?@E&<WV7VaQUV;D9E�M=ERÑ5V�:=F�>C:=KSE&<@TWÈ,A�M=ERÑrVA�8;8aQ�Í A�<P_�A�?�Q�KCE&?�E&<WV�VaQUV;D9E�8a:=>SD¦V�TWÈ�AU8a:=>SD¦V�A�8;8aQ�Í�Ï�4�D9E�<\ERø9V�?@Q�KCE1Ñ5QC8�V;D9E Ç�Ç ÒaýU?�ACB;D9:=<9EChS: Ñ�:^V�:=F�:=<�FaVRA�VaEÎ � A�<P_�VaD9E�D\E�AC_�]PQS:^<WV;F�VaQUA�ÚihW:=Fã3 Ç hPÎ I h ù jrëÜV;D9EY?�ACB;D9:=<9E�Í�8a:=V;E&FYA Ç QC<�VaD9E VRA�]`EChPB;DPAN<9>CE&F�V;Q�F;VLANVaE�Î I h9AN<P_?@Q�KSE&FYV;Q�VaD9E�8a:=>CDWVHÏ�4�D9:=F Va8RA�<9F;:^V;:=QC< :^F F;D9Q�Í�<Æ:=<Æê�:=>C6\8aEUý9Ï�4�D\EUQC]`E&8LANVa:=QC<9F 8;E�ÎS69:=8aE�_ V;Q,T\8a:=<9>�VaD9E�VLAN]PE�Ñr8aQC?A�<�caX A�V�VaD\E�MbA�FaV�V;:=?@E&F;VaE&]�4�h9V;Q@A�<�caXiANV�Va:=?@Eã4���ú�A�8aE!>C:=KCE&<�ANV�VaD9E�8;:=>CDWV%QNÑ�E�ACB;D�VRA�]`ECÏ�4�D9E!?,ACB;D9:=<9EãDPA�M=V;FÍ�D9E&<�hW:­ÑfE�KCE&8HhW:^V�:=F�:=<@F;VLA�V;EdÎ � AN<P_UV;D9EYD\E�AC_�]PQS:^<WV;F%V;QªA Ç Ï9âã<,A ö��^�N�W¯ VLAN]PE Q�ÑfÍ�D\:^V;EYF;Ȧ?UT`QCM=F7:=V�VLANßCE&F ú�ý!FaV;E&]9FVaQ�]98;:^<WV��!T9MbACB;ßUFaÈW?UT`QCM=F%AN<P_UDPANM=V�Ï7ÚÜD9:=M=E�]98;:^<WV;:^<\>©�!T9MbACB;ßUFaÈW?UT`QCM=F�:=F�<9QSVÃA �a69F;ERÑ569M �@BRQS?@]96\VLA�V;:=QC<fh�V;D9:=F Ç%Ç Òaý?,ASB;D9:=<9EY:=F�_W:=FaVa:=<9>S69:=FaD9EH_@T`E�B&AN69FaE�<9Q �&©ª�N�b�^��° 47698;:^<\>�?�ACB;D9:=<9EdB�A�<�_WQUFaQ`Ï� �Psth��P�tgkj��#h�iN�?h5r/�{r5lN}{p9h<y"nqlNr#i��[�{rx�2�tm-y�i?�xs{�2�th�uP�9dws��"gxdxi?dkh�gP¦������e��°,�9gPdesthP�{r5lN}{p9h5y�lNnCz{h�gw�9mN�{�2�tm#i����§gxdxi?dkh#�[�{rx�2�tm-y�i?�xs{�2�th

uP�9dws©deuPlVgkj�y�}�lNp9g��Q}{p9i?�x|»iN�tz uPs{�9dkh���dwsti?d-�{rk�2�{dxg�dwsth�mNr�h�i?dxh�gxdP���{y�}�h<r�lNn#}{p9i?�x|Vgkj�y�}�lNp9g }�h5nqlNr5h stiNp9dw�2�tmV¨ ª! �­e���Psth�h�¯QiNy��{p9h�uPhmN�9�?h-�9g i�gxlNp2�tde�9lc��nolcr�dwsth�dws{r5h�h gkdxi?dxh �{r5lN}{p9h5yA�Pbqn�uPh ��lN�tge�9z{h<r�dwsth �Q�{y }Ch5r#lNn/}{p9i?�x|�gxj�y }ClNp9g#desti�d#iNr�h��{rk�2�{dkh�z�}{j�desth%gklNp2�tdw�9lN�Vdkldwsth"�����e���{r5lN}{p9h5y�dkl%}�h-nx¦o� °Pu�h���iN��gwstl u dwsti?d�nk¦q��°��2�t�5r5h�i�gkh�gCnoi?gxdxh5r#destiN�ViN�{j�n �{�t��dw�9lN� ��lNy��{�tdxiN}{p9h/}{j�i��t�{rx�2�tm y�i?�xs{�2�th��{nk¦q��°sti?g }�h�h<�»z{h�dkh<rky��2�th�z�nqlNr�� �{�Adkl��$#&%*}{�td�dwsth5r5h-�9g#�tl�iNp9m?lcrk�9dws{y��9�#lNr('ky�h��xstiN�{�9��i�p*) uPiNj»dxl,+{�tz�nx¦o� ° nolNr�iN�{j��%�.-Q�{�t��dw�9lN�tg�p2�2|�hnk¦q��°-iNr5h�gkiN�9zVdxl�}Ch�/ ³.0 �21435/ ¸7698 ¹2´x�B�Ps{�9g��9g iN�Th�¯QiNy��{p9h lNn�dwsth r5h�gw�{p9dkg-desti�d���lcy��{�tdkh<r�gk�<�9h5�{de�9gxdkgP�{r5lN�?h�uP�9dwsEdwsth��[�{rk�2�tm*y�i?�xs{�2�thiN}tgxder5i?��de�9lN�/�

ý

Page 4: q s q ->

Halt

q2 R

q3 L q2

q1

q2 L

L

Rq1

q2

q3

Tape symbol read by the head:

State:

ê�:=>C6\8aE��/�74�D9E V;8LA�<\Fa:=Va:=QC<�VRA�T9M=E�ÑrQC8YA!VaD98;E&E�F;VLANVaE Ç 6\FaÈ Ç EHAHKCE&8ã?,ACB;D9:=<9ESÏ

R

Change the symbol to black.

Change the state to q2.

Move to the right.

T=1

T=0Transition

q1

q1

q2

q2

q2 R

Rq2

ê�:^>S698aE�ý��74�D9EãÌP8aF;VYVa:=?�E&FaV;E&]�Q�ÑOV;D9E Fa:=?U69MbA�V;:=QC<�Q�Ñ�VaD9E Ç�Ç Òaý�QC<�A�T9MbAN<9ßUVLAN]PECÏ

Page 5: q s q ->

����� é 0�. ����@/�C+ ��ÂT(�@�.�0�FX$'+ !/HB.�0B���ÚÜD9:=M=E�AY47698;:=<9> ?,ACB;D9:=<9E·?,AHÈ TPEYBgQC<9F;Va8a6`BRVaE�_�V;Qd:=?�]9M=E&?@E&<WVfAN<¦È!Fa]`E�BR: ÌJBYANM=>CQC8;:=VaD9? V;DPA�V�QS<9EYB&AN<U:^?�A�>NÒ

:=<9ECh�:=VdÍ�QC6\MØ_ÙTPE@AHÍ�ßWÍ�A�8L_àVaQ�DPAHKSEUVaQ�T969:=Mb_�A�<\E&Íi]9DWÈWFa:bB&ANM�?,ASB;D9:=<9E�E&KSE&8aÈÉV;:^?�E�QC<\E�Í�A�<WVaEH_ VaQ�FaQSM^KSEªAÙ<9E&Í]98;QCT9M=E&? Ï�âY<\E�� F$_ÔE&Faß�Í�QC69Mb_@ÎS69:bB;ßWM=ÈUÌPM=M�69]�Í�:=V;D,?�ACB;D9:=<9E&FY_ÔE�_W:bB&A�V;E�_�V;Q@_W: ÕJE&8;E&<WV�BRQC?�]969VLANVa:=QC<\F�Ï�ê\QC8aV;69<PANVaE&M=ÈWhA�<`_@A�?�A�Ê&:=<9>SM=Ȧh�A!4O6\8a:=<9>�?,ACB;D9:=<9EYB�A�<@T`E�BRQC<\FaVa8;6PBRV;E�_�V;DPA�V�VLANßCE&FYANFYA�<�:^<\]969V�A�_WE�FLBR8;:^]\Va:=QC<�Q�Ñ�A�<9QSVaD9E�8�4O6\8a:=<9>?,ASB;D9:=<9E@A�<P_ÀA _9A�VRA VLAN]PECh�AN<P_ÉF;:^?U6\MØANVaE&F!VaDPANVU4O6\8a:=<9> ?,ACB;D9:=<9EUQS<À:^V;FUQ�Í�<|VRA�]`ECÏÜeW6PB;DÜA�47698;:=<9>Æ?�ACB;D9:=<9E:=F�ßW<9Q�Í�<ÉA�F�A�I�<\:^KSE&8aFRA�M�47698;:=<9>�Ð�ACB;D9:=<9E�3�I�4YÐ�j�Ï�4�D9E@]`E&8;FaQC<`A�M�BRQC?�]969VaE�8aF VaDPANV�Í�EU69FaEUE&KSE&8aÈ9_9AHÈÉA�8;EU>CQWQ9_A�]\]98aQHø9:=?,ANVa:=QC<9F7QNÑOI�<9:=KCE�8aFLANMf47698;:^<\>�?,ASBaD\:^<\E&F�ëÜVaD\EY]98;QC>C8RA�?�F�VaDPANV%V;D9E&È�8a69<�A�8;Ed_WE�FLBR8;:^]\Va:=QC<9FãQ�Ñ7Fa]`E�BR: ÌJB A�M=>CQNÒ8a:=V;D9?@FYAN<P_�D\E&<PBRE�Fa]`E�BR: ÌJB�47698;:^<\>@?,ASB;D9:=<9E&F�Ï âã698 ]PE�8aFaQS<PA�M�BRQS?@]96\VaE&8;FdQS<9M=È�ѽA�M=M�FaD\QC8aV QNÑÃI�4YÐ�F :=<�V;DPA�V VaD\E&:=8?@E�?@QC8;È@B&A�<\<9QCVãTPE�ERø9]PA�<`_WE�_àE&KCE&8;È�Va:=?�EdÍ�E�<9E�E�_�?�QC8;EdF;VaQS8LA�>SECÏ 4�D9E�]\8aE&F;E&<WVLA�V;:=QC< Q�ÑÃA�?@QCM=E�Bg69MbA�8�BRQC?�]969VaE�8Í�:=VaD�VaD\Ed]`Q�Í�E&8�Q�Ñ%A�I�4YÐ :=F�VaD9E >CQWA�M�QNÑOVaD\:^F�]`A�]`E&8�Ï

� èÜåæ¾

; ��� èÜåæ¾��»�[)/@/(B!P),(B@/� +�0B�>!#��0�� ��0%)/.���0B�[ Fa:=<9>SM=EdF;Va8RA�<P_�QNÑ%XdZ1[iB&A�<àTPE M=:=ßCE&<9EH_�VaQ@A�F;VaQC8RA�>SEdVRA�]`E�VaD`A�VYB&AN<�Fa69]\]PQS8aVdA!ÑrQC698�F;Ȧ?UT`QCM�A�M=]9D`A�T`E&V�h

e�JDKH[�h��Uh�Þ h94VS�8;E&]98;E&FaE&<WV;:^<\>�VaD9E�<W6PBRM=E&QSVa:b_WE&F�AC_ÔE&<9:=<9ECh`>C6`A�<9:=<9ECh�BRÈWV;QCFa:=<9EUA�<`_�VaDWÈW?@:=<9ECÏ14�D9E&FaE�<W6PBRM=E&QSVa:b_WE&FA�8;E�<\QCVYT`QC<`_WE�_ _W:=8aE�BRV;M=È,V;Q@QS<9EªAN<9QCV;D9E&8ãT969V 8LANVaD9E&8 DPAN<9>UÑr8aQC?qAU]\D9QCF;]9DPA�V;EªAN<P_�F;69>¦AN8dT`ACB;ßWTPQS<9ECÏã4�D9EªX Z1[FaV;8LAN<P_ � F TPACB;ßWTPQS<9E�DPANFdA �Ô�N�^��°�«=��:�� AUFaEHÎC6\E&<PBREUQNÑÃX Z�[i:=F _W:=FaVa:=<PBgV�Ñ58;QC? :^V;FY8;E&KCE&8;FaECÏ!c�<�QC8R_WE&8 VaQ�8aE&]\8aE&F;E&<WV�VaD9E]`QCMbA�8;:^V�È�Í�EU<PA�?�E�VaD\EUE&<P_WF�Q�ÑYA�]9:=E�BREUQ�ÑYX Z�[�ACB�BRQC8R_W:=<9>�VaQ�V;D9EUFaV;8a6PBRV;698aE�QNÑ%:=VaF�]9D\QCFa]\DPA�V;EUTPACB;ßWTPQS<9ECÏ@âã<9EE&<P_�:=F�B&A�M=M=E�_UV;D9E��`E&<P_SëÜ:=VaF�V;E&8a?�:=<PA�M9]\D9QCF;]9DPA�V;E :^F�A�V;VLASBaD\E�_�VaQ�VaD9E���QHø9ÈW>CE�<@Q�ÑOA!Fa6\>¦A�8YAN<P_UV;D9EYQSVaD9E�8�E&<P_�:=FB&ANM^M=E�_�V;D9E�ý���E&<P_¦ë :=V;F�VaE&8;?@:=<PA�M`]9D9QSFa]9D`A�VaE!:^FYANVaVRACB;D9E�_�VaQUV;D9E�ý ��QHøÔÈW>SE&<@QNÑ#V;D9E Fa69>WA�8HÏ

4�A�ßSE&<,ANF%]PAN:=8aF�VaD9Eã<¦6`BRM=E&QCV;:Ø_ÔE&F�[ AN<P_U4æA�<P_�VaD9E <W6PBRM=E&QSVa:b_WE&FYÞÜAN<P_�� AN8aE FLAN:b_�VaQ�TPE�BRQS?@]9M=E&?�E&<WVLA�8;ȦÏ4�D9:=Ff?�E�A�<\FfVaD`A�VOAN<�[�Ò�4|]`A�:=8�QC8�AYÞ·Ò��À]PAN:=8fB&A�<!Ñ5QC8;? Í%EHA�ß�hH<9QC<WÒaBRQ�KCANM^E�<¦V�TPQS<P_WF�ߦ<\Q�Í�<�A�F7DWÈ9_W8aQS>CE&<�T`QC<`_WF7VaDPANVFaE�8aKCE�VaQ�D9QSMb_@V;D9E&?qV;QC>CE�VaD9E&8HÏ ÚÜD9E&<ÉAUF;Va8;E&VLB;DÉQ�Ñ�F;:^<\>CM=ERÒ�FaVa8RA�<P_ÔE�_ÆX Z1[iE&<PBgQC69<WVaE�8aF�AN<9QCV;D9E&8 FaV;8aE&VRBaDÉQNÑ�Fa:=<9>CM=ERÒFaV;8LAN<P_WE�_�X Z�[æVaDPANV�DPA�F�A�BRQC?�]9M=E&?@E&<WVRA�8aÈ!FaE�ÎS69E&<`BRE�VaD\EdDWÈ9_W8;QC>CE�<@T`QC<P_�:^<WV;E&8LASBRVa:=QC<\F�TPE&V�Í�E&E&<�BRQS?@]9M=E&?�E&<WVLAN8aÈ]PAN:^8;FJ×gQC:=<@V;D9E V�Í%Q�FaV;8LA�<`_WFY:=<,A!]98;QÔBgE&FaF B&A�M=M=E�_ ���9�`�L�N�­«b�Ô»�� [æ]9:=E�BRE�QNÑOFa:=<9>SM=ERÒ½F;Va8RA�<P_WEH_,X Z1[ìÍ�:=M=MPQS<9M=È@A�<9<\E�A�M�V;Q:=VaF�BRQC?�]9M=E&?@E�<¦V7: ÑO:=V�DPA�F�VaD\EdQS]9]`QCFa:=V;EY]`QCMbA�8;:^V�ÈWÏ�ÚÜD9E&<�Í%EãM^QWQSß@A�V�A�]9:=E�BgEdQNÑ#_WQS69T9M=ERÒ�FaV;8LA�<`_WE�_�X Z�[æQC<9EãFaVa8RA�<P_ERø9VaE�<P_WF�Ñr8aQC?� ��VaQUý��fA�<`_UVaD\EYQCV;D9E&8�Ñ58;QC?Ëý �PV;Q���rÏ7c�<@VaD\:^F�]PAN]PE&8�Í�E�_W8LAHÍæ_WQC69T\M^EgÒ½F;Va8LAN<P_WE�_�X Z�[æÍ�:=VaD�VaD9E VaQS]FaV;8LAN<P_�QC8a:=E&<WV;E�_����V;Q@ý��fAN<P_�VaD9E T`QCVaV;QC? FaV;8LA�<`_@QS8a:=E&<WVaEH_�ý���V;Q���5Ï

; �<; èÜåæ¾ + � +L!#��$'&�(*)/.�0�F $Y����.�(�$X Z�[�hCV;Q�A�BRQS?@]969V;E&8�FRBR:=E&<WVa:=FaVHhWM^QWQSߦF·M^:=ßSE%V;D9EYVRA�]`EYQ�ÑOA$4O6\8a:=<9> ?,ASBaD\:^<\ECÏ�4�D9EãFa:=?@:=MbA�8;:^V�ÈãDPA�F�]98;QC?@]\VaE�_

QCV;D9E&8;FUVaQÉVaD\:^<\ßÉQ�Ñd:=VUA�FUA�?�E�_W:bA�Ñ5QS8ªBgQC?@]\69VLANVa:=QC<À3Rï ñ�ò·ó�ôahYï¹þ�ÿ���óHô5j&϶[YFUFa6`BaDÜX Z�[ DPANFUFaE&KSE&8LANMdA�V;Va8RACBRV;:^KSEÎS6PA�M=:=Va:=E&FQ��Rñ�� �� ��«=�ã�5�9� »C���P�R��«5²!©ª���´��°&«5�N�­�

X Z�[ :^FãVaD9E!FaVaQS8LAN>CE�?@E�_W:=69? Ñ5QC8�>SE&<9E&F´ë V;D9EU]9MbA�<\F�Ñ5QC8ãVaD9E�]\8aQCV;E&:=<�?@QSM=E�BR69MbA�8�?�ACB;D9:=<9E&F�V;DPA�Vã]PE�8�Ñ5QS8a??@QSFaV�Q�Ñ�VaD9EYB;D9E&?�:=FaVa8;È�:=<ªANM=M¦M=:=KW:=<9>�VaD9:=<9>SF�Ï7âã698�>CE�<9E&F�_WE&VaE�8a?@:=<9E�QC6\8O?�QC8;]9D9QCM=QS>CÈWh�A�<`_�:=<��P6\E&<PBRE�QS698�T`E&DPAHKW:=QC698HÏZYANVa698RA�M=M=ÈUÍ%E�AN8aE :=<¦V;E&8aE�FaVaEH_�:=<,AN<WÈ@?@E�VaD9Q9_WF�VaDPANVYB&A�<�?�QÔ_Ô:­ÑrÈ�V;D9E&? :^<�A�>CE&<\E&8LANMfÍ�AHÈ�3 ���=»�� 47698a:=<9>�?,ASBaD\:^<\E&FLj�ÏÚÉE�ANM^F;Q@ßW<9Q�Íæ>CE&<\E&F�?@Q9_W: Ñ5ÈUV;D9E&?�FaE&M=KCE�FYÍ�:=VaDÆANM=Mf?,AN<9<9E&8�QNÑ%8aEHBRQC?UT9:=<PANVa:=QC<�E&KCE�<¦V;F�Ï!4�D9E&FaE�E&KSE&<WVaF�?�AHÈ�Ñ5QCM=M=Q�Í8a6\M^E�FYVaD`A�V�A�M=M=Q�ÍÜ69F�VaQU:b_WE�<¦V;: Ñ5ÈUVaD9E�?ËÍ�:=VaD�BRQC?�]969VRA�Va:=QS<@QC8�VaD\E�>CE&<\E&8LANVa:=QC<�Q�Ñ7MbA�<9>S6PA�>SE&F�Ï�Rþ�� ���9�&°R����°R��©U���/:@��� � :�©U�R¥a©U�R��«5���´�R��²R�9�&©�«5²R����°R�R�C²g�½«5�N�W����� B� �!�

ZYANVa698;E�]98;Q�K¦:b_WE�F�69F�Í�:=VaD�A�MbA�8a>SE �;VaQWQCM=T`QHø ��Q�Ñ7E&<9Ê&ÈW?�E&F�Í�:=VaD�Í�D9:bB;D,V;QU?,AN<9:=]969MbA�V;EYXdZ1[�ÏW4�D9E�FaE�V;Q¦QSM=F8LAN<9>CE�Ñ58aQS?)Fa:=?@]9M=E�FaV;8a:=<9>ÉB&A�V;E&<PA�V;:=QC< AN<P_ÉF;Va8;:^<\>ÆF;]9M=:^V;Va:=<9>�QC]`E&8RA�VaQS8aFUM=:=ßCEUM=:=>¦ANFaE&FUA�<P_ 8;E&FaV;8a:bBRV;:^QS<ÀE&<9Ê&ÈW?@E�F�V;QBRQS?@]9M=ERø@BRQC]WÈW:=<9>�?�ACB;D9:=<9E&8;È�M=:^ßSE�]PQSM=Ȧ?�E&8LANFaE&FHÏ7ÚÉE�FaV;E�A�M�>SE&<9E&F�Ñ5QS8%V;D9E&F;EdE�<9Ê&ÈW?@E&F·Ñ58;QC?�A�KCAN8a:=E&V�È�Q�ÑfQS8a>¦AN<9:=Fa?�F�hBRM=QC<\EdV;D9E&? :=<¦V;Q�EHA�FaÈ�>S8aQ�Í�:=<9>�TPASBRVaE�8a:bAUM=:=ßCE ¨%�%²R��� « A�<`_@D`A�8aKSE&FaV�V;D9E&?÷Ñ5QC8�6\FaE�:=<@?�QCM=E�BR6\MØAN8�T9:=QCM=QS>CÈWÏ����� B� ��«Ø�d�&©U���b�f�N�P���R�H�&«b�9:U²R�R�`«5�R���

Page 6: q s q ->

4�D9E&8;E�A�8;EE�Cü�A�V;QC?�F%]`E&8Y[1Ò½4æ]PAN:^8�A�<`_"�[�UA�V;QC?@F·]PE&8 Þ·Ò � ]PAN:=8�Ï � X Z�[ F;69]9]`QC8;VaF�ÑrQC698�F;Ȧ?UT`QCM=F�FaQUV;D9:=F>C:=KSE&FYAUB&A�]`ACBR:=V�È@QNÑYú T9:=V�]PE&8�ýSý�ANVaQC?�F�ÑrQC8Y_WQS69T9M=ERÒ�FaVa8RA�<P_ÔE�_�X Z�[�Ï94�D9E�AHKSE&8LAN>CE ?@QSM=E�BR69MbA�8�Í�E&:=>CDWV�Q�Ñ�QC<\EdT`A�FaE]PAN:^8 :=FE�[����X A�M=VaQS<9FUï � ���HôaÏU4�D9:=F�>C:=KSE&F�A�< :=?@]98;E&FaF;:=KCE�Ï ýSý�ߦ> XdZ1[���?@QSM^E!T9:=VaF�Ï� c�<|AC_9_W:=V;:^QS<fhfX Z�[�B&AN<ÉTPEA�?�]9M=: ÌPE�_�KCE�8aÈ,ÎS69:bB;ßWM=ÈUÍ�:^V;D�VaD9E ]`QCM=ÈW?@E&8RA�FaE B;DPA�:=<�8aE�ASBRVa:=QS<Æ3�õ�Þ ù j½ë Q�KCE&8�?�:=M^M=:=QC<ÔÑ5Q�Mb_�:=<,AN<�D9QC698�ï� ���&ôaÏ�� � � �R�C²g��«5���W�UöL�g��®%�R�&� �� �Û���9�L²�«5�g���H�Y�����W«b�­«rö&°&«º�¦© ��°L�!²L�N©Y�`�^�g�´���9:U°R������°R�&«5ö&�=�&�

Þ�DPAN8aM=E&F Ç E&<9<9E&V;V DPA�F�]98;QC]`QCF;E�_�VaD`A�VYBRQS?@]969V;E&8aF�T`A�FaEH_�QC<�X Z�[æQC8YA�F;:^?�:=MØAN8�?,ASBR8aQS?@QSM­E�BR6\M^E�Í�QC6\MØ_�TPE>CQWQ9_ B&A�<P_Ô:Ø_\A�VaE�F Ñ5QC8 ]98RACBRV;:bB&A�M�8aE&KSE&8aF;:=T9M=E@BRQC?�]969VaE�8aF�Ï�Z�QC8;?,ANM^M=È�BRQC?�]969VLANVa:=QC<\FdA�8;E@B&A�8;8a:=E�_ÝQC69V :=<Æ:=8;8aE&KSE&8aF;:^T\M^EFaV;E&]9F VaD`A�V�M=QCF;Ed:=<WÑrQC8a?�A�V;:^QS<ªAN<P_�_W:=FaF;:^]`A�VaE!D9E�A�VHÏ Ç E�B&AN69FaE�E&<9Ê&ÈW?�E$B�A�VLANM=ȦÊ�E�_�QC]`E&8RA�Va:=QS<9F�TPE�V�Í%E&E�<�X Z�[ F;]PEHBR:=E&FA�V!E�ÎS69:=M^:=T98;:=69?ðA�8;E,BRQS?@]9M=E&V;E&M=È�8aE&KSE&8aF;:=T9M=E,A�<WÈÆBgQC?@]\69VLANVa:=QC<9F V;DPA�V�Í�EUE&?UT`E�_ :=<ÆV;D9E&?�A�8;E@8;E&KCE&8;Fa:=T9M=E@V;QWQPÏ�[�VE�ÎS69:=M=:=T98a:=69?ÛVaD\E�Ñ5QS8aÍ�A�8L_�A�<P_�8aE&KSE&8aF;E�8LANVaE&FãQ�ÑOA�B;D9E&?@:bB&ANMP8;E�ACBgVa:=QC<�A�8aE V;D9E FLA�?�ECÏ�4�D9:=F%?�E�A�<9F·VaDPANVYA�<WȪBgQC?@]\6WÒVLANVa:=QC< A�FaF;Q9BR:bA�VaEH_�Í�:=VaDàVaD9E�8aE�ASBRVa:=QS<Æ?�Q�KCE&F�TPASB;ߦÍ�A�8R_WF�A�<P_ÙÑ5QS8aÍ�A�8L_ÔFYÍ�:=VaD�EHÎC6`A�M78LANVaE&F�ANFYÍ�E&M=M�GPQS<�AHKSE&8LAN>CE�<\Q]98;QC>C8;E&FaF�:=F�?,AS_WECÏ�47Q�_Ô8a:=KCE�V;D9E�8aE�ASBRVa:=QS<��CBRQS?@]96\VLA�V;:=QC<!Ñ5QC8;ÍÃAN8L_�8aEHACBRVRA�<WVaF�?U69FaV7T`EdAS_9_WE�_�QS8�]98aQ9_W6`BRVaF�8aE&?�Q�KCE�_ÖÏ4�D9E�E&<9E&8;>CÈU_W:=FaF;:^]`A�VaEH_�_WE�]PE&<`_WF%QS<9M=È QC<�D9Q�Í Ñ½A�F;V7QC<9E�]969F;D9E&F�V;D9EYBRQC?�]969VRA�Va:=QS<dV;Q ]98aQ9BRE&EH_�ï þ!ÿ����SôaÏfc�<�]98a:=<PBg:^]\M^EShQC<\E$B�A�<�Fa]`E&<P_�ANF�M=:^V;VaM=EYE�<9E&8a>SÈ�A�FY_WE&F;:=8aE�_�TWÈ�FaM=Q�Í�:=<9>�_WQ�Í�<�VaD\E$BgQC?@]\69VLANVa:=QC<fÏ

� Ä=�àÁàĶä9ÅÆÂàä9ç|å �,å���� ����ç�����ÄÀ¾,Âàä9ç|å Áqç|å èÜåæ¾��OQOQO5V;D9E�V�ÈW]`Edc;c%<W6PBgM^EHA�FaE�FdA�8;E�BRM=E�A�8;M^È�QC<9E QNÑ#<`A�Va6\8aE�� F�>C8;E�A�V;E&FaVã>C: Ñ5V;F�VaQ�FLBR:=E&<PBgECÏ �

ëÜ[Y8;VaDW698��ãQC8;<¦T`E&8;>@:=<,X Z�[ ù E&]9M=:bB&A�V;:=QC<47QªBg8aE�ANVaEUAUBRQC8;8aE&F;]PQS<P_WE&<PBgEUTPE&V�Í�E&E&<ÉX Z�[iAN<P_�4O6\8a:=<9>�?,ACB;D9:=<9E�F%Í�E�<9E&EH_WE�_�V;Q�ÌP<P_�FaQS?@E QC]`E&8LANVa:=QC<\F

QC<ÉX Z�[ÛVaD`A�V�BRQS69Mb_�T`EU?,AS_WE�V;QÙBgQC8a8;E&Fa]`QC<`_ÉÍ�:=VaD VaD9EU]\8a:=?@:=Va:=KSEdQS]PE�8LA�V;:=QC<9F Q�ÑYA�47698a:=<9>�?,ACB;D9:=<9ESÏ�ÚÉEUBaD\QCFaEVaQ�ERø9]9M=QS8aE�VaD9EU:=?@]\M^E�?@E&<WVLANVa: QC<@QNÑ1A�X Z�[ÛTPA�F;E�_ 47698a:=<9>�?,ASBaD\:^<\E�Í�:=VaD�V;D9E@B;D9E&?@:=F;Va8aÈ�QNÑÃ8;E&FaV;8a:bBRVa:=QS<ÉE&<9Ê&ÈW?@E�FT`E�B&A�6\FaEUÍ�E�Ñ5E�M^Vã:=Vd8;:bBaD A�<P_ BRQC?�]9M=ERø,E�<9QC69>SDÆV;Q,_WQ�F;QPÏ�âã]PE�8LA�V;:=QC<9F QC<ÉX Z�[ Í�:^V;D�VaD\EU?@QCF;VYBRQC?�?@QS<,BRMbA�F;F cac8aE�FaVa8;:bBRVa:=QC<�E&<`_WQC<W6PBRM=E�ANFaE&Fã]98aQ�KSE�_UV;Q�D`AHKCE�69<P_ÔE&Fa:=8LANT9M=E ]98aQS]PE&8;Va:=E&F�V;DPA�V�VaDWÍ�A�8aV;E�_�ERÕ�QC8aV;F�VaQ�:=?@]9M=E&?�E&<WVOA!4O6\8a:=<9>?,ASB;D9:=<9ECÏ�[ÀFa6\T9>C8;QC69]�Q�Ñ�VaD9E�BRMbA�F;F�cac�8aE&F;Va8;:ØBgVa:=QC<UE&<`_WQC<PBgM^EHA�FaE�F�hWVaD\EÃANFaÈW?@?�E&Va8;:ØB#QC8�BRMbA�F;FOc;cae�8;E&FaV;8a:bBRV;:^QS<UE&<9Ê&ÈW?�E&F�hÍ�E&8aE ÑrQC69<P_�VaQUDPAHKSE QC]`E&8LANVa:=QC<9F�Í�:=V;D@]98;QC]`E&8aV;:^E�FdV;DPA�V�M=E&<WV�V;D9E&?@F;E&M=KCE&F�?�QC8;E�8aE�AS_W:=M^È�VaQU47698;:^<\>�?�ACB;D9:=<9EY_WE&F;:=>C<fÏ

����� Å���+��C�Ýä9ä @����[)/@/.�!P)/.��%0'��0B����0�(�!#����+ �C���Ç ACBRV;E&8a:bA�E&?�]9M=Q�È °R�R�R��°&«5²g�½«r���,���P�S���9�9²��^�R�H���g� QS8 °R�R�R��°&«5²g�½«r���@��� � :�©ª�g� V;Q�BR69VY_WQS69T9M=ERÒ�FaV;8LA�<`_WE�_�X Z�[ìANV%QS8<9E�AN8�Fa]`E�BR: ÌJB1Í%QS8L_WF·ß¦<\Q�Í�<@A�F °L�g�R�½°&«r²R��«5�����&«=�a�g� QC8 °R�R²L�g»��9«=��«5�����&«=�a�R�&� 4�D9E&FaEãE&<9Ê&ÈW?�E&F�A�8aEã69FaEH_�VaQ�B;D9QS]U69]�Ñ5QC8;E&:=>C<

X Z�[�h9M=:=ßCEYV;DPA�V1Ñ58aQS?�KW:=8a69F;E&F�h`Í�D9:bB;D�E&<WVaE�8aF VaD9E!TPACBRV;E&8a:=69? Ï74�D9E�TPASBRVaE�8a:=69? � F�Q�Í�<�X Z�[ :=F�69<PA�ÕJEHBRVaE�_àT`E�B&A�6\FaEVaD\E�TPACBgVaE&8;:^6\? � F�Q�Í�<�XdZ1[ :=FYBaD\E&?@:bB&ANM^M=ÈU?�QÔ_Ô:­Ì`E�_@ANV�VaD9E�8;E�BRQS>C<9:=Va:=QS<,F;:=VaE&F :=<@F;6PB;D�A�Í�AHÈ@V;DPA�V�V;D9E�8aE�FaVa8;:bBRVa:=QC<E&<9Ê�Ȧ?�E�B&A�<9<\QCVYBR69V�:=VHÏ �

Ð�QSFaVY8;E&FaV;8a:bBRV;:^QS<ÉE&<9Ê&ÈW?�E&FY8;E�BRQC>S<9:=Ê&Ev�HÒ��UTPANFaE�]PAN:=8YFaEHÎC6\E&<PBRE&F�Q�Ñ%_WQS69T9M=ERÒ�FaV;8LA�<`_WE�_ XdZ1[�Ï`4�D9E&F;E�8;E�BRQS>�Ò<9:=Va:=QS<@Fa:=V;E&F�DPAHKCE�AN<@:=<WKCE&8;VaE�_�?@:=8;8aQC8�]9MbA�<\EY:=<@V;D9E�?@:b_9_ÔM^E�FaQUV;DPA�V�V;D9EãÌP8aF;VYDPANM ÑfQ�ÑOV;D9E�F;:^V;E :^F�VaD\E�8aE&KSE&8aF;E�Q�Ñ7VaD9EBRQS?@]9M=E&?�E&<WV�Q�Ñ7VaD9E�F;E�BRQS<P_�DPANM­ÑfQNÑ�VaD9E Fa:=V;ECÏ Ç E&M=Q�ÍÜVaD\E�:=<¦KSE&8aV;E�_�?@:=8a8;QC8�]9MbA�<9E :=F�:^<`_W:bB&A�V;E�_�T¦È�A�� Ï

3’

5’ 3’

5’

........ ACTGTGAC

CAGTGTCA

Ç :^QSM=QC>C:=F;VaF�B&A�M=M`FaE�ÎS69E&<`BRE&F Í�:=VaD@V;D9:=F�ßW:^<`_UQ�Ñ7FaÈW?@?�E&Va8;È �9���­«º�P��°R��©�«5²&� 4�D9E�BR69V;F�?,AC_ÔE�T¦È@AN<�E&<9Ê&ÈW?@Eã8aE�BgQC>C<\:^Ê�:^<\>Fa6`BaDæA FaE�ÎS69E&<`BRE|A�8;EÙANM=FaQÉ?,AS_WE@:=<ÜA�<À:=<WKCE&8;VaE�_ ?@:=8a8;QC8�FaÈW?@?�E&Va8;:ØB�Í�AHÈWÏÜâY<\E�Q�Ñ�VaD\E�?@QSFaVUBRQC?�?@QC<\M^Èà69FaE�_8aE�FaVa8;:bBRVa:=QC<àE&<9Ê&ÈW?@E�F�Q�ÑOV;D9:=F�V�ÈW]PE�:=F ¨Ã²R�&ù c �ãVaD`A�VYBR69V;FdANV�VaD9E"!$# :=<@V;D9E�8aEHBRQC>S<9:=Va:=QC<�Fa:=VaE�T`E&M=Q�ÍA�¤ �Ps{�9gP�2�t�5p2�tz{h�gPdwsth�gw�tm?iNr��o�{stl�ge�{stiNdxh/}ti?�x|Q}�lc�th#iN�tz�deuPl���i&%v�9lc�tg/�Ch5r#}ti?gxh-�tiN�2r �')( h5y�h<y }Ch5r/i�y�lNp9h �9g&%{� £+*�¯�¢N£ ± � ¥, �Psth��xsth5y��9��iNp~dxi?mN��i%y�h�dws{j?ptmNr5lN�{�{��dwsti?d��{r�l?dxh���dkgPdwsth�}ti���dxh5rx�2�{yAf g/lNuP�¡� �-���9g-i?z{z{h�zBdkl�desth�r�h���l?mN�{�9dw�9l�� gw�9dxh }~j�i�y�lQzQ� + �

��i�de�9lN��h<��-�j�y�hP|��tlNuP�Vi?g#i�y�h�dws~j�p9i?gxh ¨ .0/21 ­e�354 h-�tiNy�h�h<��-�j�y�h�g�nolNr�dwsth�lNr5m?iN�{�9gwy�gCn r�lNy=uPs{�9�xs»uPh }�lcrkr5lNuvdesth<y��v�2��des{�9g#��i?gkh7698 0;: ´=< ·�0>:?·�69?�@ ¹ · �A �Psth��Cl?gw�9de�9lN�tg�i?d�uPs{�9�xsViN�»h<��-�j�y�h#�5�tdxg#iNr�h �9dkg 0 ¹2´ 65B26 C ´D8 ·9¸ ´E8�lNr 0 / ¸q¸q·9³+C 8 · ¸ ´E85�

Page 7: q s q ->

cacrÒ�[

EcoR I

XYEcoRI

ligase

EcoRI EcoRI EcoRI EcoRIYX

XY

cacrÒ Ç

ligase EcoRIEcoR IEcoRI EcoRI

XY

XY

cacrÒaÞ

XY BamHIEcoRIEcoR I, BamH I

XY

VW

ligase

EcoRI VW BamHI

ê�:=>C6\8aE � �7âã]PE&8RA�V;:^QS<9FY6\Fa:=<9>@BRMbA�F;F�cac�E&<P_WQS<W6PBRM=E�A�F;E&F�Ï

GAATTCCTTAAG

........ GCTTAA

.... AATTCG....

<9Ê�Ȧ?�E&F7Í�:=VaD�V;D9:=FOF;ÈW?@?@E�Va8aÈ A�8;E�ߦ<\Q�Í�<�A�F�BRMbA�F;F � c;cfE&<P_ÔQC<W6PBRM=E�ANFaE&F�QS8 ZYANFaE&F´Ò½c;cOQNÑJÍ�D\:ØB;D�Q�KSE&8�ú+� ���YAN8aE�ßW<9Q�Í�<ï 8��9ó�ôaÏ

ÚÉE�B&ANM=MfVaD\E�8;E�ACBRV;:=QC<�QNÑÃX Z�[iÍ�:=V;DÆA�8aE&F;Va8;:ØBgVa:=QC<ÉE&<\Ê&ÈW?@E�A °R�R�R��°&«5²g�½«5�N�Æ��«Ø»N�g�R�½� [ 8aE&F;Va8a:bBRV;:=QC<É_W:=>CE&F;VY:=<Í�D9:bB;D�QC<\E�8aE&F;Va8;:ØBgVa:=QC< E&<9Ê&ÈW?�Ed:=Fã69FaE�_à:=F�ßW<9Q�Í�<ÆA�F A �&«b�W»��^�U��«Ø»N�g�R� G\:­Ñ�V�Í�Q@QS8YVaD\8aE&E�E&<9Ê&ÈW?�E&FdAN8aE�E&?�]9M=Q�ÈCE�_�VaD9E8aEHACBRV;:^QS<U:=FOßW<9Q�Í�<UA�F�A �S���9ö��^� ��«=»C�g�L� QS8 �½°&«³�P�^�ã��«=»C�g�L� 8;E&Fa]`E�BRV;:=KCE&M=ÈWÏ�c�<�]98LASBRVa:bBRE�V;D9E�Va8;E�A�V;?@E&<WV�QNÑJX Z�[ÜÍ�:=VaD�?@QS8aEVaD`A�<ÉVaD\8aE&EU8;E&FaV;8a:bBRVa:=QS<|E&<9Ê�Ȧ?�E&F�ANVdQS<PBREU:=F�8RA�8aEUF;:=<PBRE@_W: Õ�E&8aE&<WV�8aE&F;Va8;:ØBgVa:=QC<ÉE&<\Ê&ÈW?@E&F�?�AHÈ�BR69V�X Z�[ÛQS]9Va:=?,ANM=M^È69<P_ÔE&8d_W: Õ�E&8aE�<¦Vã8aE�ASBRVa:=QS<ÙBgQC<P_W:=V;:^QS<9F�Ï

��� ó � ó ����ÿ ���Q7 ���� ��������� � ���� ��ÿ� ��&�{7���Q7 ���Éÿ��������Éÿ� [iF;:=<9>CM=ERÒ�FaV;8LA�<`_WE�_�Q�KSE&8aDPAN<9>@A�V�V;D9E�E&<`_�Q�Ñ%X Z�[ÛBR69VYTWÈ�A�8aE&F;Va8a:bBRV;:=QC< E&<P_WQS<¦6`BRM=E�A�F;E�B&A�< A�<9<9EHA�MfV;QUVaD9E

Fa:=<9>SM=ERÒ½F;Va8RA�<P_WEH_�Q�KSE&8aDPAN<9>UQ�Ñ�AU_W: ÕJE&8;E&<WV ]9:=E�BRE�Q�ÑÃX Z�[ÛBR69VãT¦È�V;D9E�FRA�?�EdE�<9Ê&ÈW?@ERëÀÑ5QS8�VaD9:=Fã8aE�ANFaQC< Fa6`BaDàFa:=<9>CM=ERÒFaV;8LAN<P_WE�_¶Q�KCE�8aDPAN<9>CF�AN8aE�8aERÑ5E�8a8aEH_ÀVaQÆANF �R��«5²g¯~:Æ���P���g� ÚÜD9E&<ÉV�Í�QÆE�<P_WF�DPAHKCE@AN<9<9E�ANM^EH_|A�<\QCVaD\E&8�E�<9Ê&ÈW?@ECh�X Z1[M=:=>¦A�F;ECh�?�AHÈ�T`EÙAN]9]9M=:=E�_�ÏÀX Z�[ M^:=>WA�FaE�8aE&]`A�:=8aFUV;D9E�BR69VaF�:=<|VaD\E,T`ACB;ßWTPQS<9E�A�<P_¶AÆBRQS<WVa:=<W69QC69FU]\:^EHBRE�Q�Ñ$_ÔQC69T9M=ERÒFaV;8LAN<P_WE�_ÉX Z�[Û:=F�ÑrQC8a?�E�_�Ï 4�D9:=Fã]98aQS]PE&8;V�ÈÆQNÑ%8aE�FaVa8;:bBRVa:=QC<ÉE�<9Ê&ÈW?@E�Bg69V�E&<P_ÔF$ANM=M^Q�Í�FãVaD9E!Ñ5QSM^M=Q�Í�:=<9>�QC]`E&8LANVa:=QC<\FdQS<BR:=8LBg69MbA�8YX Z�[ ?�QCM=E�BR69M=E&F�ßW<9Q�Í�<,ANF �P�=�H�&©�«r�H� �� �·ÿ ����7 � �!���#"Lñ � �W����°R��«5���Æ�<4�� B� �=4&°R�H»�©ª���W��«b�W�a�@�$�P�^���&©�«5��®�«=�r�Ô�N�C����°&«5���W�a�H��«5��� ²L�N�W��°L��� �

[æFa:=<9>CM=Eã8aE&F;Va8a:bBRV;:=QC<�Fa:=VaE�3 ¨Ã²R�&ù caj�:=<,A!]9MbA�F;?@:b_!?,AHÈ�T`E�BR69V�h � M A Ñr8LA�>S?@E&<WV%$'&UÍ�:=VaD@V�Í�Q�?,A�VRB;D9:=<9> E&<P_WFA�<\<9E�A�M=E�_Öh�A�<P_ÝVaD9E�E&<P_WF�M=:^>WA�V;E�_¶3½ê�:=>C698;E � hfc;crÒ½[ j&Ï c�<ÉVaD9:=F�QC]`E&8LANVa:=QC<|ANM=M%QNÑYVaD9E�Q�KCE&8;DPA�<9>SFªAN8aE�:Ø_ÔE&<WVa:bB&A�M�h�VaD9E( �P�9lNp9l?mN�9gxdkg,�tgkh�'xdej���h )�iN�tz 'x�<p9i?gxg ) �2�{dxh5r5�xstiN�tm?h�i�}{p9j uPsth5�V�5p9i?gxgw�2noj��2�tm�r5h�gxdwrk�9��de�9lN��h5�tz{lc���t�<p9h�i?gxh5g��a*)#+ h5r5h#uPh#r5h5�{r5h�gxh5�{d�dwsth#�5�td,y�i?z{hP}~j-,���l ( bC�2��i gk�xsth<y�i?dw�9��uPiNj dwsti?dCh5y��{sti?gw� -�h�gCdesti?dCdwsth 'w�2�{�?h5r5dkh�z y��2rxr�lNrC�2y�i?m�h )#�9g��9z{h5�{dw�9��iNp

dxl��9dxgPy�i?dxh�ic�tz�sth5�t��h }�l?dws�gxde�9�x|{j�h5�tz{gPiNr5h��9z{h<�~dw�9��icp~iN�tzBgkh<p2n*�e��lcy��{p9h5y�h5��dxiNrkj��

ü

Page 8: q s q ->

Ñ58RA�>C?�E&<WV�:=F�<9QC<\QC8a:=E&<WVRA�T9M=ECh9AN<P_�VaD9E 8aEHACBRV;:^QS<�ÈW:=E&Mb_WF%V�Í�QU]98;QÔ_Ô6PBRVaFHÏ� �·ÿ ����7 � �!���#"Lþ ���^�g��«5���Æ�<4���4�°L�H»�©U�&�W�P4&°L�N©Ë� �`�^�H�&©�«5���

4�D9E�]\8aQ9_W6PBRV7QNÑ\AN<�:=<9FaE�8aVa:=QS<�QC]`E&8LANVa:=QC< :=FfV;D9E�F;69T9FaV;8LANVaE�QC8 �;:=<9]969V ��Ñ5QC87A�_WE&M=E&Va:=QS<�QC]`E&8LANVa:=QC<�Ïf[ Ñ58RA�>S?@E&<WVB&AN<ÉTPE@_WE�M^E�VaE�_ : Ñ�:^V :=F �JA�<\ßCE�_àTWÈÆV�Í�Q@8;E&FaV;8a:bBRVa:=QS<|Fa:=V;E&F Ñ5QS8dV;D9EUFLAN?@E�E�<9Ê&ÈW?@E�3�êf:=>S698aE � h�c;crÒ Ç j&Ï�4�D9EUFaQSM^6\Va:=QC<B&AN<|T`E,_W:=M=69VaEH_ 69<WVa:=MÃBgQC<P_W:=V;:^QS<9F ѽAHKSQC8�BR:=8LBg69MbA�8a:=Ê�ANVa:=QC<|AN<P_ÉV;D9E@]\MØANFa?�:Ø_àXdZ1[ËB&AN<|T`E@8aEHBRÈ9BRM=:^Ê�E�_¶Í�:^V;D9QC6\V�VaD9EÑ58RA�>C?�E&<WV�Ï �N�� �·ÿ ����7 � �!���#" � � �´�P�=�C²R�&©U���W�d�54��B4&°L��»�©U���W�%«b�Æ�$�P�=�H�&©�«r�U®�«=�r�,��°�«5�&�Ô�´���½«5�N�ƲR���W��°L�N�­�

crÑ$AàFaEHBRQC<P_ 8aE&F;Va8a:bBRV;:=QC<ÀFa:=VaESh%FRAHÈ Ç AN?,î÷c&h78aE&]\MØASBRE&FUQS<9E�Q�ÑdV;D9E�8aE&F;Va8;:ØBgVa:=QC<ÜF;:=VaE&FU<9QS8a?�A�M=M=È�69FaEH_|:=<ÀA_WE&M=E&V;:=QC< QC]`E&8LANVa:=QC<ÉV;D9E&<|A�_WQC6\T9M=E@_W:=>CE&F;Vd6\Fa:=<9> ¨Ã²R��ù c�AN<P_ Ç A�?�î c ERøPBR:=FaE�FªAN<ÆQSM^:=>SQC<W6PBRM=E&QSVa:b_WE $'&�Í�:=VaD V�Í�Q_W: Õ�E&8aE&<WVUF;Va:bB;ߦȶE&<P_WFHÏ|ÚÉE�B&A�<ÀV;D9E&<ÀM=:^>WA�V;EU:^<ÀA�Ñr8LA�>S?@E&<WV ��� V;DPA�V�DPA�FUV�Í�QÉ_W: ÕJE&8;E&<WVUE&<P_WFHh�A�FaF;698aEH_ÀVaDPANV�:=V;F:=<9FaE�8aVa:=QS<,Í�:=M=M`TPE�QS8a:=E&<WVaEH_�3�ê�:^>S698aE � h9cacrÒaÞ�j&Ï

��� ó � � � � � %�rÿ � ��T7���� ��* � � ��ÿ� ��&�{7 ����7 � �Éÿ��%� ���Éÿ� ÚÜD9:=M=E VaD9E�BaD\E&?@:=FaV;8aÈ�Q�ÑÃBRMbANFaFYc;c%8;E&FaV;8a:bBRV;:^QS<ÆE�<P_WQC<W6PBgM^EHA�FaE�Fd>S:=KCE&Fã69FdA�<W69?UT`E&8�Q�Ñ�69F;ERÑ569M7QS]PE&8RA�V;:^QS<9FYQS<

X Z�[ F;Va8a:=<9>SF�h\FaE&KSE&8LANMf]98;QCT9M=E&?�F � IYAN8aE E&<PBRQS69<WVaE&8;E�_à:­Ñ7Í%E!Va8aÈ�VaQ�69FaE!VaD9E&? VaQ@BgQC<9F;Va8a6`BRVdA�47698;:^<\>�?�ACB;D9:=<9Et���� �� %�5ÿ'� ó� �P�!�W�9« ���Ô�!�R��«5²g¯~:@���P� �9��°�°L�g�R�½°&«r²R��«5�����&� � :�©U���

Ç E�B&A�6\FaEYV;D9EYBRM=E�AHKCAN>CE�Q�ÑJA BRMbA�F;F�cac <PANFaE�Q9B&BR698;F�Í�:=VaD9:=<�VaD9E�8;E�BRQS>C<9:=Va:=QS<�F;:^V;E%EHACB;DUE&<9Ê&ÈW?�E%>SE&<9E&8RA�VaE�F%QS<9EA�<`_�QC<9M=È�QC<9E ßW:=<P_�Q�Ñ�Q�KSE&8aDPAN<9>PÏ�î1E&8aE ¯�«º�P� :=Fd_ÔERÌP<9E�_àTWÈ@V;D98aE&E�KCA�8;:bA�T9M=E&F´ë V;D9E M=E&<9>CV;Dfh`FaE�ÎS69E�<PBREChfAN<P_�]`QCMbA�8;:=V�È3 �%QS8�ý��=j�QNÑÃV;D9E@Q�KSE&8aD`A�<9>`Ï�4�D9:=F�?,AHÈ�FaE�E&?�?@QS8aE�Q�ÑdAN< �aQCTWKW:=QC69F ]98;QC]`E&8aV�È�� Q�ÑdBRMbANFaF�c;c�8aE&F;Va8;:ØBgVa:=QC<¶E&<9Ê&ÈW?@E�FVaD`A�<ÆAªÑ½ACBRV;QC8ãM^:=?�:^V;:=<9>�VaD\E&:=8d6\FaE�T969V�ÑrQC8YF;:=?@]9M=EdX Z1[ÓE�<PBRQ9_W:=<9>CFãQ�Ñ%47698;:=<9>U?,ASBaD\:^<\E&F�:=VY?,ANßCE&F�V;D9E�<¦6\?UTPE&8ãQ�Ñ8aE�FaVa8;:bBRVa:=QC< E&<9Ê�Ȧ?�E&FY8;E�ÎS69:=8aE�_à69<9?�A�<PAN>CE�ANT9M=ECÏ�crÑ�Í%E�:=?�A�>C:=<9EYA�X Z�[iE�<PBRQ9_W:=<9>@QNÑ%AU47698a:=<9>U?�ACB;D9:=<9E VaD`A�VY6\FaE&FQC<\Ed:=<9F;E&8aVRA�T9M=EãQCM=:=>CQC<W6PBgM^E�QCVa:b_WE�V;QU8aE&]\8aE&F;E&<WVYE�ASBaD�F;VLA�V;ERá¦F;ÈW?UTPQSMPV;8LA�<\Fa:=Va:=QC<�VaD9E�<,Í�E ?U69FaV·69FaE QC<\EY69<9:bÎS69E FaV;:bBaßWÈE&<P_�A�<P_�D9E&<PBgEdQS<9EY8;E&FaV;8a:bBRV;:^QS<@E&<\Ê&ÈW?@E�ÑrQC8�E�ASB;D@E&<WVa8;È@:=<UVaD\EYVa8RA�<9F;:=Va:=QC<UVRA�T9M=ECÏ KSE&<@V;D9EY:=?�]9M=E&?@E&<WVRA�Va:=QS<dQNÑfVaD9EFa?�A�M=M=E&FaV�I14YРߦ<\Q�Í�<WëìA � FaÈW?UTPQSM�hfü�FaVRA�V;E@?,ASB;D9:=<9E@ï� 7=ô=ëÜÍ%QS69Mb_�8;E�ÎS69:=8aE � � _W: Õ�E&8aE&<WV�8aE&F;Va8;:ØBgVa:=QC<¶E&<9Ê&ÈW?@E�FA�<`_@?�A�<WÈU?U69M=Va:=]9M=EY_W:=>SE&FaV;FdV;QUERÕ�E�BRV E�ACB;D�V;8LAN<9Fa:=Va:=QS<fÏ�c�<,V;D9EUeWE�BRV;:^QS<Æý9Ï�!Í%E!Í�:^M=Mf_WE�FLBR8;:^T`E�8aE&F;Va8a:bBRV;:=QC< E&<9Ê&ÈW?@E�FVaD`A�VY_WQU<9QSV%F;6WÕ�E&8ãÑ58aQS?�VaD9:=F �;QC<9E E&<9Ê�Ȧ?�ERÒ�QC<9EãE&<P_���M^:=?�:^VRA�V;:­QC<�Ï��� �� %�5ÿ'� ��� °&«5���W�a�Cö�«b�­«Ø��:U���P�ª�5�9���`°L�Sö&�=�&©q�54ã�Ã�N�­«b�P�N°L�N©�«5²����P�H�&�

4�D9E :b_WE&<WVa:bB&ANMfE&<`_WF�Í�D9:bB;DÙB�A�69F;E�_�VaD\E�QC8;:^E�<¦VRA�T9:=M=:=V�È�]\8aQCT\M^E�?�Í%E!E&<PBRQS69<WVaE&8;E�_�:=<�âY]`E&8RA�Va:=QS<,c;crÒ½[iANTPQ�KSED9:=<WVªANV�>C8;E�A�V;E&8U]98;QCT9M=E&?�F Ñ5QC8�FaÈW?�?@E&V;8a:bB�BgMØANFaF�cac <PA�F;E&F�ÏÀõ7A�M=:=<P_W8aQS?@:bB F;Va:bB;ߦÈÉE�<P_WFUM=:=ßCEUVaD\QCFaE�>SE&<9E&8RA�VaEH_|TWÈBRMbA�F;F cac <PA�F;E&F�A�8aEUA�M=Í�AHÈWFYFaE�M­ÑºÒ´BRQS?@]9M=E&?�E&<WVLAN8aÈWÏ%4�D\:^Fã?@E�AN<9FYV;DPA�VãFa:b_WE�8aE�ASBRVa:=QS<9F�h�QSVaD9E�8dV;DPA�< VaD\QCFaEU_WE&FRBR8a:=T`E�_:=<@âã]PE&8RA�V;:^QS<@c;crÒ½[�hCÍ�:=M=M9Q9B&BR698HÏ�4�D9EãMbA�8a>SE�]9MbA�F;?@:b_WF�B&A�<�h¦A�Ñ5VaE&8�T`E&:=<9>�BR69VHhWM=:^>WA�V;E�VaQC>SE&VaD\E&8%V;Q�ÑrQC8a? MbA�8a>SE&8�BR:=8LBR69MbAN8_W:=?@E�8aFOAN<P_!Va8a:=?�E&8aF�3½ê�:=>C6\8aE 9h�[ j&Ï7ê98RA�>C?�E&<WVaF�?@E�AN<¦VÖÑ5QC8�:=<9FaE&8;Va:=QC<UÍ�:=M=MCM=:=>¦ANVaE�V;Q VaD9E&?�FaE&M=KSE&F�Ñ5QC8;?@:=<9>�?U69M=Va:=?UE&8;:bB8aE�]PE�ANVaFUßW<9Q�Í�<ÉA�F ²R�N�P²R�H�a�&©U�&°g� 3½ê�:=>C698;E�9h Ç j�Ï�I�Fa:=<9>àV�Í%Q�8aE�FaVa8;:bBRVa:=QC<¶Fa:=VaE�F�h�A�FU_WE&FRBR8a:=T`E�_É:=<|âã]`E&8LANVa:=QC<¶cacrÒaÞ h_WE�Bg8aE�ANFaE&F�V;D9E�<W69?UT`E&8`Q�Ñ969<WÍÃAN<WVaE�_ãE&<P_$?,A�VRB;D9:=<9>CF`:=<dD`A�M Ñ¦T96\VfÍ�:=M=M�FaVa:=M=M�8aE�Fa69M=Vf:=<�BRQS<PB&A�V;E&?@E�8aF�ëÜV;D9E�QC8;:=E&<WVLA�V;:=QC< Q�ÑÑ58RA�>C?�E&<WVaF�Í�:=M=Ma×R69F;VOA�M=V;E&8a<PANVaE�3�ê�:^>S698aE 9h�Þ�j�Ïf4�D\E�Fa:b_WE�8;E�ACBgVa:=QC<9F�8aE&F;69M=Va:=<9>1Ñ58aQS?ìV;D9E�69F;E%QNÑÔ]`A�M=:=<P_W8aQS?@:bB`8aE�FaVa8;:bBRVa:=QC<Fa:=V;E&FY>S8aE�ANVaM=ÈU:=<PBR8aEHA�FaE�VaD\E$AN?@QS69<WV�]9698;:­Ì�B&A�V;:^QS<�8aE�ÎS69:=8aEH_@T`E&V�Í�E&E&< FaV;E&]9FdAN<P_�ÍÃANFaV;Ed8;E�A�>SE&<WVYQSM^:=>SQC<W6PBRM=E&QSVa:b_WE&FHÏ��� �� %�5ÿ'� � � �´»C�&�`�&°R�H��«5���Æ�<4�°L�g�R�½°�«5²R��«5�N�@�&«=�a�g�a5a bed[�9gt�2�{dxh5r5h�gxde�2�tm/dxl#�tl�dkhPdesti�dtdws{�9g�z{h<p9h�dw�9lN��lc��h5r5i?dw�9lN�#�9gCr5h�iNp2p9j-desth�gkiNy�h�lN��h<r�i?dw�9lN� i?g[�2�tgkh<r�dw�9lN�{��lN�{p9jPdesth�r5h5p9i?dw�9�?hC��lN�t��h5�{der5i?dw�9l��tg

lNnC�2�tgxh5r5d�iN�tz*�{p9i?gwy��9z����-��zQ�� �h<r�i�d#desth dw�2y�h�lcn�p2�9m�i?de�9lc�/�ax± �#p2p�lNn#dwsth�gxh!'w�{r5lN}{p9h5y�g�)�iNr5h�i?��de�tiNp2p9j �w�tgkd-iNr5de�2nqi?��dxg#lNn#desth�uPiNjVu�h��xstlQl?gxh�dxl�p2�2y��9d-lN�{r��tgxh�lNn�r5h�gxdwrk�9��de�9lN��h<��-�j�y�h �xsth5y��9gxder5j?�

-{lNr h�¯QiNy��{p9h?��r�h�gkdwrk�9��de�9lc��ge�9dxh�g-uPstl?gkh%ge�{}tgxh����th5�t��h�gPiNr�h��{r�h +t¯�h�gPnolNr l?desth<r#r�h�gkdwrx�9��dw�9lN�»gw�9dkh�g�gxh5r5�?h i?g desth�}ti?ge�9g nolNr i�uPstlNp9h%stl?gkd-lNnl?dwsth5rPr�h�gkdwrx�9��dw�9lN� h<��-�j�y�h�lN�Ch5r5i?dw�9lN�tg/uPs{�9�xs»��iN�»gxlNp9�?h iNp2pClNn/desth-�{r5lN}{p9h5y�gPuPh p2�9gkdPnqlNr��5p9i�gkg#bxb/r5h�gxdwrk�9��de�9lN��h5��-�j?y�h�g��C�Psth�lN�?h<rkstiN�tm�g�5r5h�i�dkh�z�}{j»�<�tdkdw�2�tm�ge�9dxh�g-uP�9desEdwsth�gxh!'w�ticr�dw�9iNp�lN�?h<rkp9ic�tg )���iN�V}Ch �xsth�u�h�z��{�/� +{p2p9h�zB�2�/�tiN�tzBp2�9m?i?dxh�z*�2�Ei��NiNrx�9h�dwj�lNn�uPiNj�g dxl�z{h�gkdwr�lNjdwsth�lNp9zBr�h�gkdwrx�9��dw�9lN��ge�9dxh�iN�tzV�<r�h�i?dkh i*�th�u�lN�th����VlNp9h��<�{p9iNr#}{�9lNp9l?m�j?��i�g#�{r5i?��dw�9��h�z��2�Ap9iN}/�Q�9g-r�h�iNp2p9j�i���lNp2p9h���de�9lN��lcnt�e�tgxd�gw�t�xs 'x�5p9h��?h5rsti?�x|{g�� )V�Cl�y�iN|�h lN�{r#r5h�gxdwrk�9��de�9lN��h5��-�j?y�h#lc��h5r5i?dw�9lN�tgC�2�tz{h<��h5�tz{h<�~dClNnPdesth-�tgxh�lcn,gw��h��5� +t� r�h�gkdwrk�9��de�9lc� h<��-�j�y�h�gPu�h stiN�?h-iN�?lN�9z{h�z�dwsth�tgxh�lcn,�<p9h��?h<r�sti��x|~gPuPsth5r5h��?h<r��Cl?gxge�2}{p9h��

Page 9: q s q ->

ñ

EcoR I ligase

EcoRI

EcoRI

EcoRI

EcoRI

EcoRI

EcoRI

þligase

XY XY XY YXXY EcoRI EcoRI EcoRI

�ligase

YXXYXY XYEcoRIYXBamHIXYEcoRIBamHI

ligase

C C C C C

ligaseD

ê�:=>C6\8aE/�7Þ�QC<PB�A�VaE�?@E&8;:^ÊHA�Va:=QS<@Q�Ñ�QSM^:=>SQC<W6PBRM=E&QSVa:b_WE&FHÏ

Ç E�B&A�6\FaE�VaD9E�BgM^EHAHKCA�>CEãFa:=VaE�FYQ�Ñ%Þ�MbA�F;F�cac <PANFaE&FãQÔB�BR698YÍ�:=V;D9:=<,V;D9E&:=8�8aEHBRQC>S<9:=Va:=QC<�Fa:=V;E&FYV;D9E�M=:=>¦A�V;:=QC<UQ�Ñ7VaD9EQ�KCE�8aDPAN<9>CF VaD\E&ÈÆBR8;E�A�V;EU8aE&F;69M=VaF�:=<�V;D9E�8;E&>CE�<9E&8LANVa:=QC<ÉQNÑ%VaD\E�QS8a:=>C:=<PANMf8aE�FaVa8;:bBRVa:=QC< Fa:=V;E&F�Ï�âY<`BRE@AU8;E&FaV;8a:bBRVa:=QS<ÉFa:=VaE�:=F69F;E�_�:=<,A�]9MbANFa?@:b_�:=V�?U69FaV�TPE�_WE�M^E�VaE�_�T`ERÑ5QS8aE�T`E&:=<9>U69F;E�_�ANVÃAU_W: Õ�E&8aE�<¦Vã]9MbACBRE :=<@V;DPA�V�]\MØANFa?�:Ø_ÖÏ

c�<|QS8L_WE�8UVaQ 8aE&?�Q�KCE,AN<|Q9B&BR6\8a8aE�<PBRE Q�ÑdAà8aE&F;Va8a:bBRV;:=QC<ÜF;:^V;E@:=V�?U69FaV�E�:^V;D9E&8�TPE��JA�<9ßSE�_¶TWÈÉV�Í%Q :b_WE&<WVa:bB&ANM8aE�FaVa8;:bBRVa:=QC<¶Fa:=VaE�F�A�F�:=<Éâã]PE&8RA�V;:^QS<|c;crÒ Ç QC8 TPE��JA�<\ßCE�_ TWÈ�V�Í�Q�_W: ÕJE&8;E&<WV�8;E&FaV;8a:bBRV;:^QS<|F;:^V;E&F�ANF�:=<�âã]`E&8LANVa:=QC<¶cacrÒaÞ Ï4�D9E&F;E�8;E&FaV;8a:bBRV;:^QS<ÆF;:=VaE&F�A�8;E�V;D9E&?�FaE&M=KCE�FY8aE�>CE&<9E�8LA�V;E�_ Í�D9E&< VaD\EªX Z�[ :=FY8aEHBR:=8LBR69MbAN8a:=Ê&E�_ A�<P_Ù?U69FaV�V;D9E&?@F;E&M=KCE&FãTPE�JAN<9ßCE�_�TWÈUQCV;D9E&8�F;:^V;E&F�: ÑOV;D9E&È,AN8aE VaQUT`E 8aE&?�Q�KCE�_ÖÏf4�D9:=F�FaQS8aV�Q�Ñ �a:=<WÌP<\:^V;EY8;E&>C8;E&FaF;:^QS< �@]\8aQCT\M^E�?�VaDPANV�8aE�ÎS69:=8;E&F�VaD9EVaD\EY69F;EdQNÑf?@QS8aE�A�<P_�?@QC8;EY_W:=FaV;:^<`BRV%8;E&FaV;8a:bBRV;:^QS<@F;:^V;E&F�?,AHÈ T`E FaQCM=KSE�_�:=<UFaE&KSE&8LANM�ÍÃAHÈWF�T969V�VaD9E&ÈU8;E�ÎS69:=8aEã?@QC8;E�VaDPAN<VaD\E$B;D9E�?@:=FaV;8aÈ@QNÑO8;E&FaV;8a:bBRVa:=QS<ÆA�<P_�M=:=>¦ANVa:=QC<fÏ��� �� %�5ÿ'��� � �g�R�½°�«5²R��«5�N�@�&«=�a�g����öR���W�P���!�r�Ô��²R��©ã�P�S�´���½«r���9�

4�D9E�8aE&>S:=QC< :^< A@]\MØANFa?�:Ø_�V;DPA�V :=F �RACB&BRE�FaFa:=T9M=E �àT¦Èà8aE&F;Va8a:bBRV;:=QC<ÉE&<9Ê�Ȧ?�E�B;D9E&?�:^F;Va8;È�:=FdEgø\ASBRVaM=È�V;D9E�8aE&>S:^QS<�aT`QC6\<P_WE�_��ÉTWȶVaD9E�V�Í�QÉ?@QSFaVU_W:=FaVRA�<WVU8aE&F;Va8;:ØBgVa:=QC<ÜF;:=VaE&FHÏÜÚÜD9:=M=E �;<9E&ÍqVRA�]`E �|B&A�<+TPE�AC_\_WE�_ÜANVUVaD9E�T`QC69<P_Ô:^<\>8aE�FaVa8;:bBRVa:=QC< Fa:=V;E&F T¦È�:=<9FaE&8;Va:=QC<�hPEHACB;DÆF;6PB;DÆQS]PE�8LA�V;:=QC<ÆAS_9_WFdA�<\E&ÍiQ9B&BR6\8a8aE�<PBRE@QNÑ�VaD9E�TPQS69<P_W:=<9>U8;E&FaV;8a:bBRV;:^QS<ÆF;:=VaERëFa:=<PBgE�:^V�:=FO<\QdM=QS<9>CE&8�69<9:bÎS69E�:^V�B&AN<9<9QSVOT`E�69FaE�_UANF�A�Fa:=V;E�Q�ÑP:=<9F;E&8aV;:^QS<fÏ�c�<�QS8L_WE&87V;Q$ASB&BRE&F;FÃA1MbA�8a>SE&8�A�?�QC69<WV�Q�Ñ�XdZ1[�h?@QS8aEU_W:=FaV;:^<`BRV�8;E&FaV;8a:bBRV;:^QS<|F;:^V;E&F�?U69FaV T`E,AC_\_WE�_ �aQS69VaF;:b_WE ��QNÑYVaD9E�ERø9:^F;Va:=<9>�QC<\E&F�Ïà4�D9:=F�M=E�AC_WF!VaQ�V;D9E@FRA�?@E�FaQS8aVQ�Ñ7:=<WÌP<9:=VaE 8;E&>C8;E&FaF;:^QS<Æ]\8aQCT\M^E�?�:=<9D9E&8;E&<WVY:=<�VaD9E�_ÔE&M=E&Va:=QC<�QNÑO8aE�FaVa8;:bBRVa:=QC<àFa:=VaE&Fã?,ANßCE&F�_WE&F;:^>S<9:=<9>UVLAN]PE�FYQ�Ñ�A�8;T9:=Va8LAN8aÈM=E&<9>SVaD�_W:��,BR69M=V�Ï

���<; Å���+��C�Ýä9ä9Á'@/���[)/@/.�!P),.���0'�-0����%0 (B!#����+ �C��� �Ç E�B&A�6\FaE�BRMbA�F;F�c;c <PA�F;E&FUDPAHKCEU8;E�BRQS>C<9:=Va:=QS<ÉFa:=VaE&F�Í�D9:bB;D|A�8;EU8aE&>SE&<9E&8RA�VaEH_ÀÍ�D9E&< Ñ58RA�>S?@E&<WVaF�A�8aEUM=:=>¦ANVaE�_Öh

T`E�B&A�6\FaE�VaD9E&È�>SE&<9E&8RA�VaE�]PANM^:=<P_Ô8aQC?�:bB�FaVa:bB;ßWÈ�E&<P_WFãÍ�D9:bBaDà:^<`BR8aE�ANFaE�Fa:b_WE�8;E�ACBgVa:=QC<9FHh�A�<P_�T`E�B&A�6\FaE�E�ACB;D�E&<\Ê&ÈW?@E�B&AN<QC<\M^È�>CE&<\E&8LANVaE�QC<9E�6\<9:bÎC6\EdF;Va:bB;ßWÈ,E�<P_�:=V�FaE&E�?@FYV;DPA�VãVaD9E�ÈÙAN8aE�<\QCVY>SQWQÔ_�B&AN<P_W:b_9ANVaE&F1Ñ5QC8�:=?@]\M^E�?@E&<WVa:=<9>�A�4O6\8a:=<9>?,ASB;D9:=<9ECÏ

û

Page 10: q s q ->

ê\QC8aV;69<PANVaE&M=ÈWh�A Fa69T9>S8aQS69]ÀQ�Ñ$BgMØANFaFUc;c�8aE&F;Va8;:ØBgVa:=QC<ÜE�<9Ê&ÈW?@E&FHh�V;D9EÆBRMbA�F;FUcacaeÝ8aE&F;Va8a:bBRV;:=QC<ÜE&<\Ê&ÈW?@E&F@_WQ <9QSV8aEHBRQC>S<9:=Ê&E�]PANM^:=<P_Ô8aQC?�:bB�8;E�BRQC>S<9:=Va:=QC<�F;:^V;E&FYA�<`_@V;D9E&È�BR69V�ѽAN8YAHÍÃAHÈ!Ñ58aQS?ËV;D9E&:=8�8aE�FaVa8;:bBRVa:=QC<�F;:^V;E&F�Ï�âã<9E�ERøPA�?�]9M=E�Q�Ñ�ABRMbA�F;F�cacae�E&<9Ê�Ȧ?�E :^F �f�H¯ c%Í�D9:bB;D,Bg69VaFQ�

CCTACNNNNNNNNNNNNNNNGGATGNNNNNNNNNNNNNNN.... ....

CCTACNNNNNNNNNNNNNGGATGNNNNNNNNN NNNNNN

NN........

ÚÜD9E�8aE�Z���KH[�hWÞ h �UhS4VS¦hS:^<`_WE&]`E&<P_WE&<WV;M^ÈWÏ74�D9E&F;E 8aE&F;Va8a:bBRV;:=QC<�E&<P_WQS<W6PBRM=E�A�F;E&FdAN8aE A�M=FaQ�ßW<9Q�Í�<�A�F �P���N�Ô�N�­«b�P�N°L�N©�«5²QC8 �H�?:�©�©U�g�½°&«r² 8aE&F;Va8;:ØBgVa:=QC<¶E&<9Ê&ÈW?@E�F�Ï�4�D9E,ANFaÈW?@?�E&Va8;È,QNÑ1BgMØANFaF�c;cae 8aE&F;Va8;:ØBgVa:=QC<¶E&<9Ê&ÈW?@E�F�A�M=M=Q�Í�F VaD9E�Ñ5QCM=M=Q�Í�:=<9><9E&Íæ8aEHACBRV;:^QS<9F�� � �� �·ÿ ����7 � �!����8 "Rñ � �W���&°R��«5�N�Æ�54�� �� � 4&°R�H»�©ª���W�%®�«Ø�5����°&«5���W�a�H��«5����²R���Ô�½°R���­�

eW:=<PBRE�BRMbANFaF�cacaeÉE�<9Ê&ÈW?@E&FUBR69V@AHÍ�AHÈàÑ58aQS? V;D9E&:=8U8aEHBRQC>S<9:=Va:=QC<¶Fa:=VaE&F�:=< AàFaV;8aE&VRBaDÀQNÑ$A�8;T9:=Va8RA�8aÈ|X Z1[ËQS<9EB&AN<ÆB;D9QWQCFaE!VaQ,Bg8aE�ANVaEUA�<�Q�KSE&8aDPAN<9>UVaD`A�VY:=F�<9QS<WÒ�]PA�M=:=<P_W8;QC?@:bB�Ï74�D\:^Fã?@E�AN<9F�VaD`A�VYA�<àQCM=:=>CQC<W6PBgM^E�QCVa:b_WE���Í�:^V;D�E&<P_WF?,ANVLB;D9:=<9>�V;D9E�M=:=<9E�AN8a:=Ê&E�_�]9MbA�F;?@:b_@B�A�<�TPE!:^<\FaE&8;VaE�_�:=<�QC<\M^È�QC<9E QS8a:=E&<WVLANVa:=QC< 3½ê�:=>C6\8aEA�9h\cacaeSÒ�[dj�Ï �;� î�E�8aE�:^V�:=FYE�ANFaÈVaQ�FaE�E�VaDPANV%QS<9E 8aE&F;Va8;:ØBgVa:=QC<�E&<9Ê�Ȧ?�EY:=F�B&A�]PANT9M=EYQNÑ#BR8;E�A�V;:^<\>U?,A�<WÈ�_Ô:­Õ�E&8;E&<WV�FaVa:bB;ßWÈ@E&<`_WF�TWÈUKCA�8aÈW:=<9>�V;D9E�A�8;T9:=Va8LAN8aÈ� <W6PBRM=E&QSVa:b_WEãFaE�ÎS69E&<`BRE�BR69V�TWÈ �f�H¯ c&ÏS4�D9:=F�FaQSM=KCE&F�VaD9E �aQS<9E�E&<P_SÒ�QC<\EdE�<9Ê&ÈW?@E ��õ78aQST9M=E&?qúYA�T`Q�KCEãT969V%BRQS<PB&ANVaE&?�E&8aF?,AHÈ�FaV;:=M^M�T`EãÑ5QC8;?@E�_Ù3½ê�:=>C698;E9h9X j�A�<P_�V;D9E 8aE&F;Va8a:bBRV;:=QC<�F;:^V;E ]PE&8;Fa:=FaV;F�AHÑ5V;E&8�VaD9E QS]PE&8RA�V;:^QS<fÏ� �·ÿ ����7 � �!����8 "Rþ �&�=�R��«5�N�Æ�54��*4&°L��»�©U���W�½�

eW:=?@]\M^EY_ÔE&M=E&Va:=QC<�QNÑ#A!Ñ58RA�>C?�E&<WV�3½ê�:=>C6\8aEA�9hWc;caeSÒ Ç j�]`A�8LANM=M^E�M^F�âã]PE�8LA�V;:=QC<�cacrÒ Ç Ï� �·ÿ ����7 � �!����8 "�� � �´�P�^�S²R�&©U�&�Ô�1�<4����Æ�N°&«5���W�a�L�*4&°L��»�©U���W�½�

[Ü]PAN:=8OQNÑÖBgMØANFaF�c;cae <PANFaEYF;:=VaE&F�Í�:=V;DUQC]9]`QCF;:^V;EY_W:=8aE�BgVa:=QC<9F�B&A�<UT`E�69FaEH_UVaQ ]98;E&]PAN8aEYV�Í�Q�Q�KSE&8aDPAN<9>CF�_WE�8a:=KCE�_Ñ58;QC?�_W: ÕJE�8aE&<WVYF;E�ÎS69E&<PBgE&F�3�êf:=>S698aEA�9hScacae¦Ò´Þ Ϲj�Z�Q�ÍÜ<9E�:^V;D9E&8�V;D9E :^<\FaE&8;Va:=QC<�QCM=:=>CQS<W6PBRM=E&QCV;:b_WE&F�3�êf:=>S698aE 9h j�hW<9QC8�VaD9EBR69V!]9MbA�Fa?�:b_@X Z�[ÛDPAHKSE�F;E&M Ñ1BRQS?@]9M=E&?�E&<WVLAN8aÈ@E�<P_WF�AN<P_�VaD\E@_WE&Fa:=8;E�_ :=<9FaE&8;Va:=QC<ÉBRQS?@]`E&VaE&F Í�:=VaD ?,AN<WÈUÑ5E&Í�E&8�F;:b_WE8aEHACBRV;:^QS<9F�Ï·4�D9:=F�FaQSM^KSE&F�]98;QCT9M=E&?�FÃõ78;QCT9M=E&? ��T969V�VaD\Ed8;E&FaV;8a:bBRV;:^QS<�Fa:=V;E&FYF;Va:=M=M�]PE&8;Fa:=FaV AHÑ5V;E&8�VaD\E�QC]`E&8LANVa:=QC<�Ï� �·ÿ ����7 � �!����8 "� ���^�g�½«5�N�Æ�54���4&°R�H»�©ª���W�%®�«Ø�5�,�N�C�a�H¥L���C²&«=�&«5�N���<4�°L�g�R�½°�«5²R��«5�N�U�&«=�a�R�&�

Ç ACB;ß�VaQUTPASBaß�Q9B&BR6\8a8aE�<PBRE&F�Q�Ñ%BRMbA�F;FYc;cae�8aE&F;Va8;:ØBgVa:=QC<�E�<9Ê&ÈW?@E&F!3½ê�:=>C698;EE�9h\cacaeSÒaX j�B&A�< BR69VYV;D9E&?�FaE&M=KCE�FYQC6\VQ�Ñ�A�]\MØANFa?�:Ø_ A�<`_ÉVaD\E,]\MØANFa?�:Ø_ÉB�A�<|T`E�8aE5×gQC:=<9E�_¶Í�:=VaD9QS69V�VaD9E�8aE�>CE&<9E�8LA�V;:=QC<ÀQ�Ñ�A�8;E&FaV;8a:bBRVa:=QS< F;:=VaE�_WE&FRBR8a:=T`E�_À:=<õ78;QCT9M=E&?qý9Ï � �� �·ÿ ����7 � �!����8 " � � ���`�^�S²L��©U�&�W�Y�54����Æ�N°&«5���W�´�R�*4&°L��»�©U�&�Ô�%®�«=�r�@�r�Ô�����C²�«=�&«5���Æ�<4�°L�g�R�½°�«5²R��«5�N�U�&«=�a�R�&�

4�D9:=FYQS]PE�8LA�V;:=QC< :^F AUF;Va8LAN:=>CDWV�Ñ5QS8aÍ�A�8R_�BRQC?UT\:^<`A�Va:=QS<@Q�Ñ�FaVa8RA�V;E&>C:=E&F�6\FaE�_à:=<�âã]`E&8LANVa:=QC<9F c;caeSÒ´Þ AN<P_àcacaeSÒaX�Ïî�E�8aE@V�Í�Q�TPASB;ß�VaQ�T`ACB;ßÆ8;E&FaV;8a:bBRV;:^QS<|F;:^V;E&FUA�8aEU6\FaE�_ÝVaQ�]98;E&]PAN8aE@Q�KSE&8aD`A�<9>SF�_WE&8;:^KSE�_àÑ58;QC? _Ô:­Õ�E&8;E&<WVªBRM=E�AHKCAN>CEUF;:^V;EFaEHÎC6\E&<PBRE&FHÏ�4�D9:=F�QC]`E&8LANVa:=QC<�FaQSM=KCE&F�T`QCV;DÙõ#8aQCT\M^E�?@F �UA�<P_�ý9Ï� �·ÿ ����7 � �!����8 "�� �b�%°R�R»�°L�g�R� �¶©ª� ����©U�&�W�d�<4����������Ô���P²R�!�r�¦°L�N�S»������R�½°R���P�U�<4 �� ���a�� �Psth�gxh�iN�tz%y�iN�{j l?dwsth5rPlN��h<r�i?dw�9lN�tg[��l�gkgw�2}{p9h�uP�9dws»�<p9i?gxg�bxb�� ,��ti?gkh�g/iNr5h#�{r5h�gxh5�{dkh�z �2��iN�Vh�¯Q��h5p2p9h<�~d[r5h����9h�uviNr5dw�9�5p9hP}{j �&-�j?}tiNp9gw|Q�,´ ¸

6 ¹ ��¨ ���{¬N­�� �th��<p9i?gxg�bxb��BlN��h<r�i?dw�9lN���tl?d-gestlNuP�Vsth5r5h�dwsti?dPy�iNj +{�tz*�tgkh%�2�A���-����lNy��{�tdxi?dw� lc� �9g��Qj&-5}tiNp9gw|��ef g�'w�{�{�9�?h<r�gxiNp{r5h�gxderx�9��dw�9lN�h5��-�j?y�h ){��iVgw��h��5�9iNp/i?z{iN�tdxlNr�lNp2�9m�lN���t�<p9h�l?dw�2z{h�dwsti?d r�h���l?mN�{� -�h�g#iN�TiNrk}{�9dwr5iNr�j�gxh����th5�t��h lNn�ge�2�tmcp9h �egkdwr5iN�tz�h�z�� ��� ic�tzAzQ�2r�h���dxg�iB�5p9i?gxgbxb���h<��-�j�y�h#dkl��5�tdP�9d#i?d-iN�»icrk}{�9dwr�icr�j �Cl?gw�9de�9lN�/��¨ �����­ax¤ bq��des{�9gPgx�xsth5y�i?dw�9��dwsthPr5h���l�mN�{�9de�9lc� ge�9dxh�lcn��/����b��9g�r�h<�{r�h�gkh<�~dxh�z }{j�desth��������p9iN}Ch5p9h�z�iNrxr�lNu�uPs{�2p9h �9dkgP�5�tdxdw�2�tm�gw�9dxh#�9g�r�h<�{r�h�gkh<�~dxh�z

}{j�desth-p9lN�tm?h<r 'xiNrxyA� ) + h5r5h�dwsth h5�tz{g#�5r5h�i�dkh�z�}~j �/��� b#iNr5h zQr�iNuP���2�AuPiNj�dwsti?d#h5y��{sti?gw� -�h�g/dwsti?d�dwsth�'w�2�{�?h5r5dkh�z�y��2rkr5lNrP�2y�i?m?h )�lNn/imN�9�?h<��h5�tz*�9gP�tl?dP�9z{h5�{de�9��iNp{dkl%�9dkgPy�i�dkh iN�tz��9g �tl?d�gxh5p2n �e��lNy��{p9h<y�hx�~dxi�r�j��a=' bedC�9gP�2�{dkh<r�h�gkdw�2�tm#dkl��tl?dkh#dwsti?d/dws{�9gPlN��h<r�i?dw�9lN� �{r5l ���9z{h�g�desthP�{r5l�lcntdesti?d�i �tiN�2r#lNnt�5p9i?gxgPbkb���r5h�gxderx�9��dw�9lN� gw�9dkh�g/��ic��ge�2y��{p9i?dxh 6N³ º-�5p9i?gxg

bxbCr�h�gkdwrx�9��dw�9lN� gw�9dkh����Cl�ge�2y��{p9i?dxh#iN�~j%�5p9i?gxg�bxb/h<��-�j�y�h"! uPs{�9�xs��5�tdxg�i�r�h�gkdwrk�9��de�9lc� ge�9dxh#���?iNp2ptu�h-�th�h�z�dxl�z{l �9g�r�h<�{p9i?��h#h�i?�xs lQ���<�{rkr5h5�t��hlNn���uP�9desVdesth#gxdwrk�2�tm$�&%&%"'(� uPsth5r5h#%&%)'�r�h<�{r�h�gkh<�~dxgCi �tiN�2r�lNn[}ti?�x|�dkl }ti��x|�r�h�gkdwrx�9��dw�9lN��ge�9dxh�g�nolNr#i��<p9i?gkgPbxb���h<��-�j�y�h+*�uPs{�9�xs�r5h���l�mN�{� -�h�g%�iN�tz�uP�2p2p/�5�td��2�Adesth���gkh ��h<�t��h�g/dkl��5r5h�i�dkh-desth gxiNy�h-|��2�tz�lNn/lN�?h<rkstiN�tm dwsti?d"!�z{l�h�g#uPsth5���9d#�<�tdkg��

ú+�

Page 11: q s q ->

cacae¦Ò½[

Fok I CFok I Fok I

C

ligase

Fok I

cacae¦Ò Ç

ligaseFok I Fok I Fok I Fok IFok IFok I

Fok IC

Ccacae¦Ò´Þ

ligase

C

Fok I Fok IFok I

Fok IFok IFok IFok I D

D

C

cacae¦Ò´X

Fok IFok I

Fok I Fok I

Fok I ligase

cacae¦Ò

Fok I Fok IFok I

Fok I Fok I

ligaseD

D

cacae¦Ò´ê

Fok I

ligase

Head Fok I Fok I

Fok IFok I

Fok I Fok I

Fok IHead Fok I

D

D

D

DDDD

D

C C C

C C C C C C C C

C

C C C

CCC

ê�:^>S698aEA����âY]`E&8RA�Va:=QS<9F�69Fa:=<9>@Þ�MbANFaF�cac�F�E�<P_WQC<W6PBgM^EHA�FaE�F�Ï

úCú

Page 12: q s q ->

ñ

L R RL Invq1R L

þ

R L Rq1InvL R L

ê�:=>C698;E$ü���[ã<,:=<9F;VLAN<¦VRA�<9E�QC69F _WE&FLBg8a:=]9Va:=QS<�Q�Ñ%A�4YÐ :=<,Í�D\:ØB;D�VaD\E�VLAN]PE�D\QCMb_WF�VaD\E�FaV;8a:=<9> ����� hWV;D9E�D9EHAC_�]`QC:=<WVaFYANVVaD\E � FaÈW?UT`QCM�h¦AN<P_UV;D9E�?�ACB;D9:=<9EY:=F�:=<,F;VLANVaE����¦Ï

4�D9E�M=ERÑrVYDPANM­Ñ�QNÑ·ê�:=>C6\8aEE�\hPc;caeSÒaê|F;D9Q�Í�FYÍ�D`A�VYÍ�E�?�E�A�<�TWÈ �;]98aQS>C8aE�FaF��`GfAUF;E�ÎS69E&<PBgE���� �@?�Q�KCE&F�V;QUVaD9E8a:=>SD¦V!VaD98;QC69>SD|A�FaV;8a:=<9>�QNÑ ��F;E�ÎS69E&<PBRE�F,A�<`_ 8aE&]9MbASBRE&F�VaD9E&? Í�:^V;D���F;E�ÎS69E&<PBgE&F�Ï � �Û4�D9E�8a:=>CDWV�DPANM ÑÃQNÑYVaD9E�ÌP>S698aE_WE&?�QC<9F;Va8RA�VaE�FYD9Q�ÍæV�Í%Q�TPASBaß�V;QUTPACB;ß@Q9B&Bg698a8;E&<PBRE&F�Q�Ñ �Ö��¯ c�BRQS69Mb_@T`E�69F;E�_�V;Q@?@Q�KSEf×R69F;VYFa6`BaD A���� �UFaEHÎC6\E&<PBRECÏ4�D9:=FUQC]`E&8RA�Va:=QS<Ü:=FU8aE�ANM^M=È�×R69FaV�A KCA�8;:ØANVa:=QC<¶Q�Ñ�âY]`E&8RA�Va:=QS<ÜcacaeSÒaXq:=<ÀÍ�D9:bB;DìA ]PAN:^8UQNÑ�TPACB;ß|V;Q|TPASB;ß|8aE�FaVa8;:bBRVa:=QC<Fa:=V;E&F DPAHKCE�TPE�E&<�AS_9_WE�_àVaQ�VaD9E�8a:=>SD¦V QNÑ#F;E�ÎS69E&<PBgE���:=<�VaD9E�:=<9FaE�8aV�F;69TC×RE�BRV!VaQ@V;D9EUBRQC<9F;Va8RA�:=<WVdV;DPA�VãVaD9EU8;:=>CDWVa?�QCFaV8aEHBRQC>S<9:=Va:=QC<�Fa:=V;EdD`A�FYAUBRM=E�AHKCAN>CEYF;:=VaE VaDPANVY_WQWE&FY<\QCV�M=:=EYE&<WVa:=8;E&M=È@:=<@V;D9E�:=<9FaE�8aV�Ï

4�D9:=F�QS]PE&8RA�V;:^QS<@D9:=>SD9M=:^>SDWVaF7VaD9E A�T9:=M=:=V�È Q�ÑOA�F;ÈW?@?@E�Va8a:bB78;E&FaV;8a:bBRV;:^QS<�E&<P_WQS<¦6`BRM=E�A�F;E&F�VaQ �;8aE�ASB;D@QC6\V���AN<P_UBR69VX Z�[iAHÍ�AHÈ�Ñr8aQC? VaD\E&:=8�8aE�BRQS>C<9:=V;:^QS<@F;:^V;E�?,ANßW:^<\>d8;E&>C:=QS<9F�Q�Ñ�XdZ1[ �aQS69VaF;:Ø_ÔE �UQ�Ñ7VaD9E V�Í�QU?@QCF;V%_W:=FaVRA�<WV�8aE�FaVa8;:bBRVa:=QC<Fa:=V;E&F �RACB&BRE�FaFa:=T9M=E �NëÜFaQCM=KW:=<9>Uõ78aQST9M=E&? � Ï

4�D9E@BRMbANFaF cacae 8;E&FaV;8a:bBRVa:=QS<ÉE&<P_WQS<¦6`BRM=E�A�F;E&F�h7V;D9E&<fh7B&A�< T`EU69FaE�_ V;Q�FaQCM=KSEªANM^M7QNÑÃV;D9E�]\8aQCT\M^E�?@F QC69V;M=:^<\E�_�:=<eWE�BgVa:=QC<�ý9Ï=úCÏ�9Ï � �!c�<@VaD\EY<9ERø9V�F;E�BRVa:=QS<@Í�Ed_WE&FRBR8a:=T`E�D9Q�ÍÀVaQ�69F;EYVaD\E&:=8�QC]`E&8LANVa:=QC<9F�VaQ!:^?�]9M=E&?@E�<¦V7A�47698;:=<9>�?,ASB;D9:=<9ECÏ

� ¾ èÜåì¾ ÁYÅ�� � ��¾�Â�ä\Å���ç|Ä Â���� ¿É¿�� � Â�� �

47Q�QC8a>WA�<9:=Ê&E�VaD\EUERø9]9MbA�<PANVa:=QC<�QNÑÃQS698�X Z�[ÛFRBaD\E&?,ANVa:bB�Í�E�8aE�B&ANM=M%QS<9E�<`A�Va6\8LA�M�_W:=K¦:=F;:^QS<�Q�Ñ�VaD\EUE&M=E&?@E&<WV;FQ�Ñ%A�4O6\8a:=<9>U?,ASB;D9:=<9Et�7KCA�8;:bA�T9M=E E&M=E&?@E�<¦V;F�h`A�<P_�BgQC<9F;VLA�<WVãQC<9E&FHÏdê�:=8aF;V�h`VaD\E�KCA�8;:ØANT9M=E E&M=E&?@E&<WV;FYA�8aE�8aE�]98aE&F;E&<WVaE�_ TWÈAUF;:=<9>CM=E�BR:=8RBR69MbA�8 XdZ1[i?�QCM=E�BR69M=ECG\<9ERø9V�hÖVaD9E�V;8LAN<9Fa:=Va:=QS<�VLANT9M=E�:=FYE&<PBgQÔ_ÔE�_ TWÈ,QSM=:^>SQC<W6PBRM=E&QSVa:b_WEã:^<\FaE&8;VaF�GÖÌP<PANM=M^ÈWhWFa: øB;D9E&?�:ØB�A�M9F;VaE&]9FYAN8aE _WE&FLBg8a:=TPEH_@Í�D\:ØB;D�A�]9]9M=È�VaD9EãQCM=:=>CQS<¦6`BRM=E&QCV;:Ø_ÔE%E&<`BRQ9_WE�_�Va8RA�<9F;:^V;:=QC<UVLANT9M=EYV;Q�AC_WKCAN<PBREãVaD9Eã4O6\8a:=<9>?,ASB;D9:=<9EYQS<9E Va:=?@E&F;VaE&]�Ï

����� � 0�!#���B.�0BFG+ 0>.�0B�t)/+ 0%),+ 0B����(B� ���-�C!#@/.�&*),.���0ê�:=>C698;E$ü�F;D9Q�Í�F�VaD\E�V�Í%Q�Í�AHȦF�Í�E E&<PBRQ9_WE�A�<�:=<9FaVRA�<WVLAN<9E&QC6\FY_WE&FLBg8a:=]9Va:=QS<�Q�Ñ7VaD9E Ç�Ç Ò´ý�4YÐ :=<�Í�D9:bBaD�VaD9E

VLAN]PE�D9QSMØ_ÔFOV;D9E�FaVa8;:=<9> ����� h&V;D9E�D9E�AC_!]`QC:=<WVaF�A�V�VaD9E�F;Ȧ?UT`QCM � h�A�<`_�V;D9E%?�ACB;D9:=<9E�:=F�:^<!FaVLANVaE����WÏ�4�D9E�8aE&]\8aE&F;E&<WVLA�V;:=QC<Q�Ñ�F;Ȧ?UT`QCM=FHhWD9E�AC_Ù]PQSFa:=Va:=QC<�h9A�<P_�?�ACB;D9:=<9EãFaVLANVaECh�ANFYÍ�E&M=MfA�FYV;D9E�8;E�A�F;QC<�Í�E�A�M=M=Q�ÍÜV�Í�QUKCE&8;Fa:=QC<\FYQ�Ñ%AN<¦È�]PA�8;Va:bBR69MbAN8caX�h9A�8;EdEgøÔ]\MØAN:=<9E�_�TPE�M^Q�Í�Ïa=,���l?dP�{�{p2�2|�h-desth-sth�i?z�lNn/i��[�{rk�2�tm y�i��xs{�2�th?¥a 3 �#�tl?dwsth5r�gw�{}tmNr�lc�{�¡lcn�dwsth��5p9i?gxg�bxb�r5h�gxdwrk�9��de�9lN�Ah<��-�j�y�h�g���dwstl?gxh dwsti?d r5h���l?mN�{� -�h�'w�2�~dxh5rxrx�{�tdkh�z��tiNp2�2�tzQr5lNy�h�g�)Q�{stiN�?h��5�td%ge�9dxh�g �2�

iNrx}{�9der5iNr5j�gxder5h�dx�xs�lNn/� ��� }Ch�deuPh�h<�»dwsth�deuPl�stiNp9�?h�g�lNn/uPsti?d#uPlN�{p9zBl?desth<r�uP�9gxh#}Ch i��tiNp2�2�tzQr5lNy��9�Pge�9dxh?�/�Ps{�9gPy�h�iN�tgPdesti?d#dwsth�j�z{l%�tl?dgw� �h5rPn9r5lNy���r�lc}{p9h5y�g�¢%iN�tz *�}{�td�}�h���iN�tgxh#desth<�2r��<p9h�iN�Ni?m?h#gw�9dkh�g#iNr�h �2�tge�9z{h-lNn/desth<�2r�r5h���l?mN�{�9dw�9lN� gw�9dkh�g#desth�j ��iN�{�tl?d/gxlNp9�?h��/r5lN}{p9h<y�g��iN�tzB® i?g#z{l�dwsth��<p9i?gxg#bkb��*h5��-�j?y�h�g��NuP�9destlc�td�dwsth-�tgkh lNn/lN�?h5rxp9iN�{�{�2�tm r�h�gkdwrk�9��de�9lc� gw�9dkh�g��

ú �

Page 13: q s q ->

ñ

W

B

þ

L R

L R

L R L R L R

ê�:=>C698;E ����e9B;D9E&?�A�Va:bB1E&<PBRQ9_W:=<9>UQNÑOVaD\E�T9MbACB;ß@A�<`_@Í�D\:^V;E FaÈW?UTPQSM=F�Ï

� � ó � ó 8���� ���� 4�Í�Q�_W:=F;Va:=<PBRVUX Z�[ FaE�ÎS69E&<`BRE&F�A�8;E,6\FaE�_¶VaQ 8aE�]98aE&F;E&<WV�VaD9E�FaÈW?UTPQSM=F � A�<P_ � 3½ê�:=>C698;E �9h�[dj&Ï ASBaD¶:=F

Fa6\TJ_W:=KW:b_WE�_ :=<WVaQÆAÙM^EgÑ5V�A�<`_ 8a:=>CDWV DPA�M ÑLÏ�4�D9E�XdZ1[�47698a:=<9>�VRA�]`E,A�F!FaD9Q�Í�<É:=<|ê�:=>C698;E@ü�:=F�<9QCV�×R69FaV�VaD\EUFa:=?@]9M=EB&ANVaE&<PANVa:=QC<àQ�Ñ � A�<P_ � FaE�ÎS69E�<PBRE&FHÏ�47QUE�ACB;D FaÈW?UT`QCM�Í�E�A�]9]`E&<P_ÖhPQS<�VaD\E�M=ERÑ5V�h�A�F;D9QC8;VdF;E�ÎS69E&<PBgEUMØANTPE�M^M=E�_ � h�A�<P_ÖhQC<ÉV;D9E@8;:=>CDWV�h�A�F;D9QC8;V�F;E�ÎS69E&<PBgE�MbA�T`E&M=M^EH_��|3�êf:=>S698aE �9h Ç j�Ï Ç E�B&A�6\FaE�V;D9E&È|A�8;E@V;D9E@FRA�?@EU:=<ÉT`QCV;DÉVaD9E � A�<P_ �FaÈW?UT`QCM=F�VaD9E&F;EUFaE�ÎS69E�<PBRE&F�AN8aE�B�A�M=M=E�_�VaD\E�M=ERÑ5VdAN<P_�8a:=>CDWV «b� ����°&«5�N�W� F;E�ÎS69E&<PBRE�F�Ï�4�D\E�X Z�[iF;E�ÎS69E&<PBgE�Ñ5QC8YA�4O6\8a:=<9>VLAN]PE�3rÍ�:^V;D9QC6\V�VaD9E�D\E�AC_9j�D\QCMb_W:=<9>�V;D9E�FaV;8a:=<9> ����� :=F�FaD9Q�Í�<�:=<,ê�:=>C698;E��9h9Þ Ï

� � ó � � 1 �Oÿ �7ÿ'Pò4�D9E�V�Í�Q TPACB;ß�V;QdT`ACB;ß�A�F;ÈW?@?@E�Va8a:bB78;E&FaV;8a:bBRV;:^QS<UFa:=VaE�F�MbA�T`E&M=M^EH_�������A�<`_ ����:=<Uêf:=>S698aE�üã8aE&]98;E&FaE�<¦V�V;D9E�D9E�AS_

Q�Ñ7VaD9E!4O6\8a:=<9>�?,ACB;D9:=<9ESÏf4�D9E!8aE&F;Va8a:bBRV;:=QC<�F;:^V;E MØANTPE�M^M=E�_�Í�:=VaD�V;D9E FaVLANVaE�ANM=ÍÃAHÈWF�]PQS:^<WV;F�VaQUVaD\E$Bg698a8;E&<WVdF;ÈW?UTPQSMJAN<P_�����,A�M=Í�AHÈWF%]`QC:=<WVaF A�VYA�<�AS_&×&ACBgE&<WVY:=<WKCA�8a:bAN<¦V�FaEHÎC6\E&<PBRECÏ âã698YE�<PBRQ9_W:=<9>@>SE&<9E&8RA�V;E&F V�Í%Q@X Z�[ 8aE&]\8aE&F;E&<WVLA�V;:=QC<9FãÑ5QS8A�<WÈU]PAN8aV;:ØBg69MbA�8�caX T`E�B&A�6\FaE�Í�E ]9MbACBRE VaD\EdD\E�AC_�Q�Ñ7VaD9E 47698;:^<\>�?,ASBaD\:^<\E �a:=<9F;:b_WE ��Q�ÑOV;D9E VLAN]PECG\QC<9Eã8aE&]\8aE&F;E&<WVLA�V;:=QC<35[ j ]`QCFa:=V;:^QS<9F VaD9EUD\E�AC_ F;E�ÎS69E&<PBRE�V;Q,V;D9EU8a:=>SD¦V QNÑÃV;D9E,BR6\8a8aE�<¦V�FaÈW?UT`QCM�hPAN<P_ VaD\EUQCVaD\E&8U3 Ç j ]`QCF;:^V;:=QC<9F�V;D9EUD9E�AS_FaEHÎC6\E&<PBRE�VaQUV;D9E�M=ERÑ5VHÏ74�D9E�]9DWÈWFa:bB&ANM�:^<WV;E&8a]98;E&VLANVa:=QC<àQ�ÑOV;D9E&F;E�V�Í�QU]PQSFaF;:^T\:^M=:=Va:=E&F�:=F�VaD9:=FQ�7:­Ñ�V;D9E D9E�AC_Ù:^F�V;QUVaD9E 8;:^>SDWVQ�Ñ�V;D9EªBg698a8;E&<WVdF;ÈW?UTPQSM�VaD9E&< VaD\E�MbA�F;V�?@Q�KSEYQ�Ñ�VaD9E�?�ACB;D9:=<9E Í�A�FYV;Q@V;D9E�M=ERÑ5VHGJBgQC<WVa8RA�8a:=Í�:=FaEShP: Ñ�VaD\E�D9EHAC_�:=FYV;QUVaD9EM=ERÑ5V�QNÑOVaD\E$Bg698a8;E&<WVdF;ÈW?UTPQSMPV;D9E&<�VaD9E!MØANFaV�?�Q�KCE�Q�Ñ7VaD9E!?,ACB;D9:=<9E�Í�A�F�V;QUVaD9E 8;:^>SDWV�Ï

� � ó � � 1 �Oÿ #�����ÿc�VY:=F VaD\E ���9�C²�«b�W» TPE&V�Í�E&E&<ÉV;D9E�8aE�BRQS>C<9:=V;:^QS<�Fa:=V;E�MbA�T`E&M=M=E�_ ���UA�<P_ÙVaD9EUBR698;8aE&<WV FaÈW?UT`QCMfV;DPA�VãE&<PBRQ9_WE�F�VaD9E

FaVRA�V;E@Q�Ñ�VaD\:^F�47698a:=<9>�?�ACB;D9:=<9ECÏ@Þ�QS<9Fa:b_WE�8�V;D9E���TPANFaE@]`A�:=8�QCM=:=>CQS<W6PBRM=E&QCV;:b_WE � hfV;D9E�ÌP8aF;V�D`A�M ÑÃQNÑYVaD9EUF;ÈW?UTPQSM � hFaD\Q�Í�<,T`E&M=Q�ÍA�

W’GAAACACTTTGT

=

4�D9E � TPA�F;Ed]`A�:=8ÃBg69VaV;:^<\>�8;E&>C:=QC<�Q�Ñ �Ö��¯ c�?,AHÈ!TPE 69F;E�_�VaQ@BR69V�FaEHÎC6\E&<PBRE � :^<�A�<WÈUQC<\EYQ�Ñ7VaD98;E&E�_W: Õ�E&8aE�<¦VYBg69VaV;:^<\>4&°R��©U�R� T¦È KCAN8aÈW:=<9>�VaD9E�<W69?UT`E&8�Q�Ñ9:=<WVaE&8;KCE&<9:=<9>ãTPA�F;E&F7TPE�V�Í%E&E�<UVaD9E �Ö��¯ c�8;E�BRQS>C<9:=Va:=QS<�Fa:=VaE�A�<P_ V;D9E�FaÈW?UTPQSM�FaE�ÎS69E�<PBRE3½ê�:=>C6\8aE�ûCj�Ï

ÚÉE@A�F;FaQ9BR:bA�V;E@V;D9EUÑ58RA�?�EU:^<ÉÍ�D\:ØB;D|A�F;ÈW?UTPQSM�FaE�ÎS69E�<PBRE�:=F�BR6\V�Í�:=VaDÉV;D9E,BgQC<PBRE�]9VUQ�ÑYF;VLA�V;E�:^<|AÙ4O6\8a:=<9>?,ASB;D9:=<9EªAN<P_ B&A�M=M�VaD9EUE&<\Ê&ÈW?@EU69F;E�_ÉV;QÙBg69V�F;ÈW?UTPQSMOF;E�ÎS69E&<PBgE&F@:=<É_W: ÕJE&8;E&<WV�Ñr8LA�?�E&F�A�� ������UE&<9Ê�Ȧ?�EUQC8�� ������BR69V;VaE&8HÏ ASB;D�DPA�M Ñ�Q�Ñ�AUFaÈW?UT`QCM�F;E�ÎS69E&<PBRE�:=FYMbA�8;>CE�E&<\QC69>SD�VaQ�TPEUBR69V :=<�VaD\8aE&E!Ñ58LAN?@E&FãTWÈ�� ������ªBR69V;VaE&8!E&<9Ê&ÈW?@ESÏÇ ÈÙB�A�8aEgÑ569M=M=È@]9:bB;ßW:^<\>@_W: ÕJE&8;E&<WV�XdZ1[iF;E�ÎS69E&<PBRE�F Ñ5QC8ãE�ACB;D�F;ÈW?UTPQSM½hWV;D9E�F;Va:bB;ߦÈ�E&<`_�>CE&<\E&8LANVaE�_àTWÈÙBg69VaV;:^<\>,A�>C:=KSE&<FaÈW?UT`QCM�:^< >C:=KSE&<Æ8;ERÑ5E&8;E&<PBRE�Ñ58LAN?@E�B�A�< TPEU?�AC_WE�6\<9:bÎC6\ECÏUêf:=>S698aE�ú+��FaD\Q�Í�FdV;D9EUQ�KCE�8aDPAN<9>CF >CE�<9E&8LANVaE�_ÝÍ�D9E&< VaD9E

ú�ý

Page 14: q s q ->

ñ

Fok I Fok I

NNNNNNNNN

NNNNNNNNNCCTAC

GGATG GAAACA

CTTTGT

NNNNNNNNN

NNNNNNNNNCCTAC

GGATG

CTTT GT

GAAACA

W’

þ

NNNNNNNN

NNNNNNNNCCTAC

GGATG GAAACA

CTTTGT

NNNNNNNN

NNNNNNNNCCTAC

GGATG

Fok I Fok I

CTTTG

G

T

AAACA

W’

Fok I Fok I

NNNNNNN

NNNNNNN

CCTAC

GGATG GAAACA

CTTTGT NNNNNNN

NNNNNNN

CCTAC

GGATG GA

CTTTGT

AACA

W’

ê�:=>C698;E$û��OX Z1[iA�<P_�FLB;D9E&?�A�Va:bB18aE&]98;E&FaE�<¦VRA�V;:^QS<9F Q�Ñ �Ö��¯ c�BR69V;Va:=<9>@A!Fa: ø@TPANFaE ]PA�:=8�F;E�ÎS69E&<PBRESh � hS:^<�E�ASB;D,QNÑOV;D98aE&E]`QCFaF;:=T9M=EUÑ58RA�?@E�F�Ï�Z�QSVaE�VaDPANV�V;D9E@F;DPA�]`E�Q�ÑYVaD\E,BR69VU:=<ÉV;D9E@FRBaD\E&?,ANVa:bB�8aE&]\8aE&F;E&<WVLA�V;:=QC<ì_W: Õ�E&8aF�:=<ÉE�ACB;D¶8aERÑ5E�8aE&<PBgEÑ58RA�?@Egë V;D9EdBgM^QSFaE&8�V;D9E�8;E�BRQC>S<9:=Va:=QC<�Fa:=VaE!Q�Ñ �f�H¯ c%V;Q � V;D9E�D9:=>SD9E&8�VaD\E �;<9QCVRB;D �U:=<@VaD\E�FLB;D9E&?�A�V;:ØB1FaV;:ØB;ßWÈ@E�<P_�Ï

ú �

Page 15: q s q ->

q2

q3

q1

L

L

L

R

R

R

q1

q2

q3

R

R

R

L

L

L

q1

q2

q3

R

R

L

L

RL

q3

q2

q1

L

L

L

R

R

R

ê�:=>C698;E,ú&�/�YâãKCE�8aDPAN<9>CF�>SE&<9E&8RA�V;E�_ Í�D9E&<ÉT9MbASBaß�AN<P_�Í�D\:^V;E�F;ÈW?UTPQSM^FYAN8aEUBR69V�TWÈ�VaD\E � ������@BR69VaV;E&8�:=<Æý�_W: Õ�E&8aE&<WVFaVRA�V;E Ñ58LAN?@E&F·Ñ58;QC?�V;D9E M^EgÑ5VYA�<P_�Ñ58;QC?�V;D9E 8a:=>CDWVHÏ

FaÈW?UT`QCM=F � A�<P_ � A�8;EdBR69V�:=<@E�ASB;D@Q�Ñ7VaD9EãVaD98;E&E Ñ58RA�?�E&F7Ñ58;QC?ÛVaD9Eã8a:=>CDWV�A�<P_ªÑ58aQS?ÛVaD9EãM^EgÑ5V�Ï74�D9Eã8aE&F;Va8;:ØBgVa:=QC<�Fa:=V;E�Ñ5QS8E�ASBaD�Ñ58RA�?�EY:=F�MbA�T`E&M=M^EH_UÍ�:=VaD�VaD\EdF;VLANVaE�:=V�8aE&]98;E&FaE�<¦V;F�A�<`_@F;DPAC_ÔE�_�VaQU?,ANVLB;D,ê�:=>C6\8aE��9Ï

���<; � 0�!#���B.�0BF )/H�� )/@/+ 0��C.5)/.��%0')/+ � ���4�D9E�6\<9:bÎC6\E�FaV;:ØB;ßWÈ@E�<P_WF Í�D9:bB;DÙB�A�<�T`E�>CE�<9E&8LANVaE�_àTWÈ,BR6\VaVa:=<9>�A�FaÈW?UT`QCM�Í�:=VaD�� �������BR6\VaVaE�8$ANM=M^Q�Í+69FYV;Q

M=:=>¦A�V;ECh9:=<WVaQUQS698dX Z1[iVLAN]PEShJA ��°L�N�W�&«=��«5���É��� «=»N�N�9�9²&�=�R�H��«5�C� Í�D9:bB;D,E�<PBRQ9_WE&F�V;D9E�<9E�ÍiFaVRA�V;ECh`FaÈW?UTPQSM�h9A�<P_�_Ô:^8;E�BRV;:^QS<Q�Ñ�V;D9E�47698a:=<9>U?�ACB;D9:=<9ECÏ7[�V A�<WÈ@>S:=KCE&<�Va:=?�E&FaV;E&]�A�4O6\8a:=<9>U?,ASB;D9:=<9E�� F%MbANFaV�?@Q�KSEY?�AHÈUDPAHKCE T`E&E&<�V;Q@VaD\E�8a:=>CDWV�QS8M=ERÑ5VHh9A�<P_�:^V;F�<9ERø9V�?@Q�KSE�?,AHÈ�T`E VaQUV;D9E 8a:=>CDWV�QC8�M^EgÑ5V�Ï74�D9:=F�?@E�AN<9F�VaDPANV%V;D9E&8aE�A�8aEãÑ5QS698�TPA�F;:ØBã]9MbAN<9F�ÑrQC8�Va8LAN<9Fa:=V;:^QS<QCM=:=>CQS<W6PBRM=E&QCV;:b_WE&Fã3½ê�:=>C698;EªúSú�j�Ï74�D9E&:=8�]PA�8;VaFYAN8aE�_WE&FRBR8a:=T`E�_�T`E&M=Q�ÍA������ :=F�VaD9E�BRQSD9E&Fa:=KSE�E&<P_�?,ANVLB;D9:=<9>�V;D9E�E&<`_@>SE&<9E&8RA�V;E�_�TWÈ@BR6\VaVa:=<9>@A�>S:=KCE&<�FaÈW?UTPQSMPÍ�:=V;D,V;D9E � � ���������� ���Ï� ��|:=FYA�8;E&FaV;8a:bBRVa:=QS<�Fa:=VaEãÑ5QS8�VaD9E � �������8aE&F;Va8;:ØBgVa:=QC<�E�<9Ê&ÈW?@ECÏ7c�VYBg69VaFãVaD9E�Bg698a8;E&<WVYFaÈW?UT`QCM�ACB&BgQC8L_Ô:^<\>@VaQ�VaD\E�FaVRA�VaE

Q�ÑOV;D9E�?�ACB;D9:=<9ECÏ�� :^F7V;D9E�8aE&F;Va8;:ØBgVa:=QC<�Fa:=VaE�ÑrQC8fV;D9E ������� �� ��ã8aE&F;Va8;:ØBgVa:=QC<�E&<9Ê&ÈW?�ECÏfc�V�BR6\VaF�V;Q$Bg8aE�ANVaE�VaD\E%FRA�?@E·Fa:=Ê&EYA�<`_�QS8a:=E&<WVLANVa:=QC<

Q�KCE&8;DPA�<9>�ANFdV;D9E � ������U8aE�FaVa8;:bBRVa:=QC<ÉE�<9Ê&ÈW?@E�T969V :=V DPA�F�A�_W:=FaV;:^<`BRV�8aEHBRQC>S<9:=Va:=QC<�F;:=VaECÏU4�D\:^F F;:^V;EªANM=M^Q�Í�FãVaD9EBRQCD9E�Fa:=KCE�E�<P_�V;Q�TPE·]98aE&]`A�8aEH_�T¦È BRM=E�AHKCA�>SE7Í�:^V;D�VaD\E ��� ��� �� ��E&<\Ê&ÈW?@E�A�<P_$:^F�69FaEH_ ���9� : :=<�VaD9E·?,A�<W6WÑ�ACBRV;698aEQ�ÑOV;D9E�V;8LA�<\Fa:=Va:=QC<�QCM=:=>CQS<¦6`BRM=E&QCV;:Ø_ÔE&F�Ï

��� �ÆÑrQC8 �a8;E&Fa6\M^V �U:=FYA�F;E�ÎS69E&<PBRE�E&<PBgQÔ_Ô:^<\>UVaD9E�<\E&ÍìF;ÈW?UTPQSM½Ï� ��ò �ÜA�8;E�V�Í%QU_W:=FaV;:=<PBRV �a:=<WKCA�8;:bA�<WV���X Z1[ FaE�ÎS69E&<`BRE&F VaDPANV�FaE&]`A�8LANVaE�F;ÈW?UTPQSMP]PAN:=8aF�:=<�VaD9E�X Z�[ F;E�ÎS69E&<PBRESÏ������%$��� �#ò �����ÜA�8aE BRMbA�F;F%c;caeU8aE�FaVa8;:bBRVa:=QC<�Fa:=VaE�F�Í�D9QCF;EYE&<9Ê�Ȧ?�E&F�A�M=MJBgM^EHAHKCE � QC8��VaQ�>S:^KSEYV;D9EYFRA�?@E�F;:=Ê&EdAN<P_UQS8a: Ò

E&<WVLA�V;:=QC<�Q�KCE&8;DPA�<9>`Ïf4�D\E&FaE�F;:^V;E&F%AN8aE�69F;E�_�VaQ�BRM=E�AHKSE � QC8 ��F;E�ÎS69E&<PBRE�FYA�V7KCA�8;:^QS69F7FaVRA�>CE�F�Q�ÑPV;D9EYBRQS?@]969VRA�V;:^QS<fÏ����@:=F�8aEHBRQC>S<9:=Ê&E�_�TWÈ@V;D9E�����@E&<9Ê&ÈW?�ECh �����UTWÈ@VaD\E����������� ���UE&<9Ê&ÈW?�ECh9A�<P_ $�T¦ÈUV;D9E��� �� ����� ������ ��� � �E&<9Ê&ÈW?@ESÏ

ú

Page 16: q s q ->

Inv

CapInv

Cap

Cap

Inv

CapInv

Em

Em

X X

XX

X X

XX

Next move to the left:

Next move to the right:

RCoh StaL

StaR

Coh R L Res R

L RRes L

L

Coh

Res LR

Sta L

L CohSta RLR Res R

Em

Em

Last move to the left

Last move to the right

Last move to the left

Last move to the right

ê�:=>C698;E@úCú[��4�D9E ÑrQC698�Ñ5QS8a?�F%V;8LA�<\Fa:=Va:=QC<�QSM^:=>SQC<W6PBRM=E&QSVa:b_WE&F�VRA�ßCESÏ%[1Ñ5VaE�8YT`E&:=<9>,BRM=E�AHKSE�_�Í�:=VaD�������� �� �UE&<9Ê&ÈW?@E V;Q8aE�?@Q�KCEãVaD9E �� F;E�ÎS69E&<PBgE&F�h�EHACB;D�Va8LAN<9Fa:=V;:^QS<@QSM^:=>SQC<W6PBRM=E&QSVa:b_WEdB�A�<�TPE�_W:=KW:b_WE�_�:=<WVaQ �F;E�BRVa:=QS<9F�� � ���fhWVaD\EdF;Va:bB;ßWÈ@E&<P_Fa]`E�BR: ÌJBãV;QªA!]PA�8;Va:bBR69MbAN8%F;VLA�V;ERÒ�FaÈW?UTPQSMPBRQS?UT9:=<PA�V;:^QS<fh�V;D9EYD9EHAC_UF;E�ÎS69E&<PBgE@3 � ��� � � � Wj�hCV;D9E 8aE&F;69M=V�8aE&>S:^QS<���� �9hSVaD9EFaÈW?UT`QCM Ò�ERøPBR:=Fa:=QC<�Fa:=VaE�F $Jh9AN<P_UV;D9E ����@FaEHÎC6\E&<PBRECÏ �����ª?�A�VRBaD\E&FÃA!FaÈW?UT`QCMPBg69VY_W698;:^<\>�V;D9EYMbA�F;V%V;:=?@E&F;VaE&]�T¦È � ������BR69V;VaE&8�E�<9Ê&ÈW?@ECÏ�crÑ�VaD9Eã?,ACB;D9:=<9E�� F7MbA�F;V�?@Q�KSE�Í�A�F�V;Q�VaD9EãM=ERÑ5V�h � ���U:=F�VaD9E�M=ERÑrV�E&<P_�Q�Ñ�VaD9EãVa8LAN<9Fa:=V;:^QS<�QSM=:^>SQC<W6PBRM=E&QSVa:b_WEA�<`_ K¦:bBRE�KCE&8;FLA\Ï�4�D9EUF;Ȧ?UT`QCM Ò�ERøPBR:=Fa:=QC< Fa:=V;E&F $ÉA�8;E@A�M=Í�AHȦF!]9MbACBRE�_ <\ERø9V�V;Q�VaD9E�FaV;:ØB;ßWÈÉE&<P_ �����fÏ ���É:=F�]9MbACBgE�_QC< VaD\E@QC]\]PQSFa:=VaEUE&<`_ Q�Ñ�VaD9EUQSM^:=>SQC<W6PBRM=E&QSVa:b_WECÏ Ç E&V�Í%E�E&<|V;D9E $�AN<P_ ����ÆF;E�ÎS69E&<PBgE&FUÍ%EU]\MØASBREUVaD\EUD9E�AC_ÉAN<P_���� �FaEHÎC6\E&<PBRE&FHÏ�4�D9E � � $Fa:=VaE�:=<UVaD\E�D9E�AC_�F;E�ÎS69E&<PBgEd]`QC:=<WVaF7:=<UVaD\EY_W:=8aE�BRV;:=QC<UVaD\E�D9E�AC_�F;E�ÎS69E&<PBgEdÍ�:=M=MW?@Q�KSECÏ�4�D9E�8;E&Fa69M=V8aE�>C:=QC<�:=FÃANM=ÍÃAHÈWF�]9MbACBRE�_ �;TPE&D\:^<`_��UVaD9E!D9E�AC_�F;E�ÎS69E&<PBREShPV;DPA�V�:=FHh9<9ERø9V�V;Q � ����Ï

ú��

Page 17: q s q ->

ÚÉEUVa8RA�<9F;MbA�VaE�VaD9E�V;8LA�<\Fa:=Va:=QC<ÉVRA�T9M=E�Ñ5QC8�V;D9E Ç 69F;È Ç E�AHKCE&8U?�ACB;D9:=<9E�>C:=KCE�<É:^<|ê�:=>C6\8aE �à69F;:^<\>�VaD9E�FaE�Ñ5QC6\8�Ñ5QS8a?�F�h?,ANßW:^<\>�QS<9E�QSM=:^>SQC<W6PBRM=E&QSVa:b_WE Í�:=VaDÆA�F;Va:bB;ߦÈ�E&<`_ ������VaQ�?,ANVLB;D�E�ACB;D E&<P_à:^< êf:=>S698aE�ú+�\Ï 4�D9:=FY>CE�<9E&8LANVaE&F!VaD9E�VaD9EQCM=:=>CQS<W6PBRM=E&QCV;:b_WE�E&<PBgQÔ_ÔE�_UV;8LA�<\Fa:=Va:=QC<�VLANT9M=E%>S:=KCE�:^<Uê�:=>C698;E�ú �9Ï � #U[ �Yø ��4YÐ÷E&<PBgQÔ_ÔE�_UV;D9:=FOÍ�AHÈ�DPANF �5�.�!Va8LAN<9Fa:=V;:^QS<QCM=:=>CQS<W6PBRM=E&QCV;:b_WE&F�Ï

����� � + � .�0�FG+�)/@/+ 0��C.5)/.��%0�� ��.�0�F �?@/�%$ ��0��æäWè )/�L),HB��0B����) �[Y<É:=<9F;VLAN<¦VRA�<9E�QC69F�_WE&FRBR8a:=]9V;:=QC< Ñ5QS8 Ç�Ç Ò´ý�?�ACB;D9:=<9E�QS]PE�8LA�V;:=<9>�QC<ÉA�T9MbA�<9ßàVLA�]`EU:=F FaD9Q�Í�< :=<�ê�:=>C698;E�ú�ý\Ï

4�D9E�F;E&8a:=E&FãQ�Ñ �U_W:=FaV;:=<PBRVYB;D9E&?�:ØB�A�M�FaV;E&]9F 8aEHÎC6\:^8;E�_�V;QUVLA�ßSE VaD9:=F�caXiANV�Va:=?@Eã4ìV;QUVaD9E!caXiA�V�V;:=?@EY4���ú�AN8aE�F;D9Q�Í�<:=<,ê�:=>C698;EUú�ýUA�<`_@A�8;E�ERø9]9MbA�:=<9EH_UT`E&M=Q�ÍA�

eWV;E&]9F�úRÒ � 8;E&]9MbACBRE�VaD9E�D9E�AS_ÉÍ�:=VaD¶VaD9E�BRQC8;8aE�BRVUV;8LAN<9Fa:=Va:=QS<ÉQCM=:=>CQC<W6PBgM^E�QCVa:b_WEU:=<|AN<É]98aQ9BRE&F;F,AN<PA�M=QC>SQC69F V;Qâã]PE�8LA�V;:=QC<�cacaeSÒ ÏúSÏ�Þ�69VfV;D9EYBR698;8aE&<WV�F;Ȧ?UT`QCM�Í�:=V;D�VaD9E � ������ÃA�<`_ ��� ������ ���ã8aE&F;Va8a:bBRV;:=QC<�E&<9Ê&ÈW?@E�F�Ï � � 4�D9E � � ����ÃBg69VaV;E&8%BR8;E�A�V;E&FA�<�E&<`_�69<\:ØÎS69E�VaQãVaD9E�BR698;8aE&<WV�F;ÈW?UTPQSM¦A�<`_ VaD9EYBg698a8;E&<WV�FaVRA�VaESÏf4�D9E ����� ���� � � BR69V;VaE&8%BgM^EHAHKCE&F�A�< � FaE�ÎS69E�<PBREVaQ@BR8;E�A�V;E�A�<�E&<P_�V;DPA�V�:=F�VaD\EdFRA�?�EY8aE�>¦A�8R_WM=E&FaFãQ�Ñ7Í�DPA�V�F;Ȧ?UT`QCM=F�M=:^EãVaQUV;D9E M^EgÑ5V�Q�Ñ7VaD9E�BgQC?@]\69VLANVa:=QC<fÏ2I M

�\Ï�Ð�: ø�VaD9EãV�Í%E�M^KSE�Va8RA�<9F;:^V;:=QC<UQCM=:=>CQS<W6PBRM=E&QCV;:b_WE&F7:=<ªê�:=>C698;E�ú �YÍ�:=V;DUVaD9E XdZ1[Ü47698a:=<9> VRA�]`E&F�Ï2I � âã]`E&8LANVa:=QC<�cacaeSÒ A�FaF;69?@E�F�V;DPA�VUV;D9E�QCM=:=>CQC<W6PBgM^E�QCVa:b_WE�:=<9FaE&8;V�� :=F�DPA�FU69<\:ØÎS69E�BRQSD9E&F;:^KSE�E&<P_WF�QC<|T`QCV;DÀE&<P_WFHÏ Ç E�B�A�69F;EÆQS<9M=ÈVaD9E FaV;:ØB;ßWÈÀE&<P_+>CE&<\E&8LANVaE�_+TWÈ V;D9E � �������BR6\VaVaE�8�:=F@69<9:bÎS69E�Í�E ßCE&E&]æVaD\E�FaV;:ØB;ßWÈÜE&<`_ÜQS<ÜVaD9EàVa8LAN<9Fa:=V;:^QS<QCM=:=>CQC<W6PBgM^E�QCVa:b_WE7V;DPA�V�?,A�VRB;D9E&FfV;D9E�E&<P_!>CE&<9E�8LA�V;E�_!T¦È V;D9E ���������� ���dBR6\VaVaE�8�]98aQSVaE�BgVaE�_�TWÈ VaD9E ����dFaEHÎC6\E&<PBRECÏI�FaE�XdZ1[ìM=:=>¦ANFaE VaQ�×RQS:^<�VaD9E!Va8LAN<9Fa:=V;:^QS<@QSM^:=>SQC<W6PBRM=E&QSVa:b_WEYV;Q�V;D9E�VRA�]`ECÏ

ý\Ï�Þ�M^EHAHKCEYV;D9E ����@FaE�ÎS69E�<PBRE�VaDPANV�]98aQSVaE�BRV;F VaD9E :=<WKCA�8a:bAN<¦V·FaE�ÎS69E&<`BRE ��QC<�VaD\EdQSM=:^>SQC<W6PBRM=E&QSVa:b_WECÏ2INI� Ï�Þ�:^8RBR69MbA�8;:=Ê&E@V;D9E�XdZ1[qÍ�:=VaD X Z1[ËM=:=>¦ANFaECÏÉc�<`BRQC8;8aE�BRV�M=:^>WA�V;:^QS<9F�B&AN<|Q9B&BR6\8@: ÑYVaD9E�M=ERÑ5VUBRQSD9E&Fa:=KSE�E&<P_ÝQ�Ñ$AN<:^<WKCAN8a:bA�<WV�FaEHÎC6\E&<PBRE�QS<�QC<9E�X Z�[¶VLA�]`E�FaVa:bB;ßWF7VaQ VaD9E�8a:=>SD¦V7BRQCD\E&Fa:=KCE�E&<P_!Q�Ñ�A�<�:=<WKCA�8;:ØAN<WV�FaE�ÎS69E&<`BRE�QC<UA�<9QSVaD9E�8XdZ1[|VRA�]`ECÏf4�D\E%8;E�ACBRV;:=QC<�B&AN<�T`E�8a69<�ANVfKSE&8aÈ�_Ô:^M=69V;E%BRQS<PBRE&<WVa8RA�V;:^QS<9F7Q�ÑPX Z�[¶FaQ VaDPANVf:=<WVa8RA�?@QSM=E�BR69MbA�8�BRM=QCF;698aE:^F�Ñ�AHKCQC8;E�_�ÏeWV;E&]9F �A�<P_ ��FaE�8aKCE�VaQY_ÔE&M=E&VaE�VaD9E�]98;E&KW:^QS69FaM=Èã8aE�AS_�F;Ȧ?UT`QCMHÑr8aQC?æVaD\E�VLAN]PE�69Fa:=<9>�V;D9E�BRQC<PBgE&]9V7Q�Ñ��a]\8aQC>S8aE&F;F��

_WE&KSE&M=QC]`E�_�:=<,âã]`E&8LANVa:=QC<�c;caeSÒ´ê�Ï\Ï�Þ�69V Í�:^V;D �� �� � ��� ���� � ��� � �@8aE&F;Va8a:bBRV;:=QC<ÉE&<9Ê�Ȧ?�ECÏ�4�D9:=F�BR69VaF�AHÍÃAHÈ�VaD\EU]98aE&KW:=QC6\F�FaÈW?UT`QCMOAN<P_àM^EHAHKCE&F V�Í�Q?,A�VRB;D9:=<9>�:=<WKCA�8a:bAN<¦V·E&<P_WFHÏ

�\Ï ù E�BR:=8RBR69MbA�8;:^Ê�E�Í�:=VaDÆX Z�[ M=:=>¦ANFaE VaQ ×RQC:=<�VaD\E�:=<¦KCAN8a:bA�<WV�E&<P_WF�BR8;E�A�V;E�_à:^< 9Ï�[YFã:^<à:^< � h98aEHACBRV;:^QS<ÆBRQS<P_W:=Va:=QC<\FFaD9QS69Mb_@T`E�AS_&×R69F;VaE�_�V;QUѽAHKSQC8�:=<¦V;8LAN?@QCM=E�Bg69MbA�8�BRM=QCFa6\8aECÏ�4�D9E�� ������ªBR69V;VaE&8 8;E&FaV;8a:bBRVa:=QS<�Fa:=VaE!<9Q�Í �;]PQS:=<¦V;F��UV;QVaD9E�BR698;8aE&<WV FaÈW?UT`QCM�A�<P_�VaD9E�XdZ1[ VLAN]PE QC<`BRE�A�>WA�:=<U8aE�]98aE&F;E&<WVaF�AN<�:^<\FaVLAN<WVLA�<\E&QC69FY_ÔE&FLBR8;:=]9Va:=QC<�Ï

eWV;E&]9FÆúgÒ<�àA�8aE�8;E&]PEHA�VaEH_Ü69<WV;:^M�A������� :=FU:=<PBRQC8;]PQS8LANVaE�_ÀA�<`_ÉVaD\EÆBRQC?�]969VRA�Va:=QS<Æ:=F@_WQS<9EC϶[�Ñ5V;E&8@A�<WÈ|F;VaE&] �àVaD9EBRQS?@]969VRA�V;:^QS< ?,AHÈ�B;D9E�B;ßCE�_!ÑrQC87VaD9E�:=<PBgQC8a]`QC8RA�V;:^QS<�QNÑJA �� ��� FaEHÎCE�<PBRECÏ�4�D9:=F�B&A�<�T`EY_WQC<9E�TWÈ�õ�Þ ù A�?�]9M=: ÌJB&A�V;:=QC< Q�ÑAãFa?�A�M=M9A�M=:bÎC6\QCVfQNÑJV;D9EdBgQC?@]\69VLANVa:=QC<�6\Fa:=<9> �� ����F;E�ÎS69E&<PBgE$ANF%Aã]98a:=?�E&8�Ïfâã<9M=È�DPA�M=V;E�_�VLAN]PE&F·Í%QS69Mb_�T`EYA�?�]9M=:­Ì`E�_Së: Ñ#_WE�VaE�BRV;E�_àVaD9E&È�BRQS69Mb_�VaD9E&<�T`E�FaEHÎC6\E&<PBRE�_àVaQU8;E�BRQ�KSE&8YV;D9E�A�<\FaÍ�E&8�Ï·4�D9:=F�FLB;D9E&?�Ed:=F�ÌP<\Ed: Ñ�A�M=M�Q�Ñ�VaD\E$X Z1[ VLA�]`E&Fa=A ��l?dxh�dwsti?d/dwsth 'xuPs{�9dxh�gw�ti?��h )#}Ch�deuPh�h<� i�mN�9�?h<���������-�5�tdxdxh5r/r5h���l?mN�{�9dw�9lN��ge�9dxh�iN�tz�dwsth�i?zN�xi?��h<�~d[�2�{� icrk�9iN�{dCgkh �?�th<�t��h���lcr� �zQ�� �h<r�g

}�h�deuPh�h5�AiN�TlNp2�9m?lN�Q�t�5p9h�l dw�9zQh�h<�t��lQzQ�2�tm�i��xstic�tm?h�lNn#zQ�2r�h���dw�9lN�A¦�´ � C ��y�lN�?�2�tm%n9r5lNy dwsth p9h5nqd�m�lN�2�tm�dkl�dwsth%p9h5nod5°#lcr�ic�ElNp2�9m?lN�Q�t�5p9h�lNde�9zQhh5�t��l�zQ�2�tm%i��{r�h�gkh<r��Ni?dw�9lN��lNn�zQ�2r5h���dw�9lN�A¦�´ � C �-y�l ���2�tm%n9r5lNy dwsth-p9h5nod��{��lN�{dw�2���{�2�tm dxl�desth rx�9mNs{d�°<��b§n�desth%�t�{rx�2�tm%y�i?�xs{�2�th#|�h�h5�tgPy�lN���2�tm�2�Edwsth�gxiNy�h�zQ�2r5h���dw�9lN�Vdesth<�¡dwsth5r5h�iNr5h�uP�2p2p�icp9u�iNjQg�}Ch�deuPlB�2�~�NiNrx�9iN�{d�gxh����th5�t��h�gP}�h�deuPh�h5�Adwsth���������gkh �?�th<�t��h-�2�Edwsth sth�i�z»ic�tz»dwsth�5�{rxr5h5�{d#gkj�y }ClNp�gxh��Qh5�t��h?�Pbqn�dwsth��[�{rx�2�tm�y�i?�xs{�2�th �xstiN�tm�h�g#zQ�2r5h���dw�9lN��dwsth5�BnolNr desth �th�¯�d y�lN�?h desth<r�h-�9g lN�{p9j�lc�th��2�{�NiNrx�9iN�~d#gxh����th5�t��h}�h�deuPh�h5�Adwsth5yA��bq�TlN�{r�gk�xsth<y�i?de�9�-iN�A�2�{�NiNrk�9ic�~d#gxh����th5�t��h��9g%desth�uP�9z{desAlNn�¢*�5�tdxde�2�tm%n9r5iNy�h�gxlVdesth�'xuPs{�9dkh�ge�ti���h )%�2�Edwsth dwr5iN�tge�9dw�9lN�lNp2�9m?lc���t�<p9h�l?dq�9z{h5g,sti?gP}�h�h5��i?zN�w�tgkdxh�z�i?����lNr5zQ�2�tmNp2j?�a*( �Ps{�9g�y�iNjB}�h%��h<rknqlNrxy�h�z�i?g�iBz{lN�{}{p9h�zQ�9m?h�gkd-lNr�deuPl»gxh����th5�{dw�9iNp�zQ�9m?h�gkdxg#�2n�dwsth��������iN�tz��������?����N����h5��-�j�y�h�gPr5h����{�2r5h }{� �h<r�g

dwsti?d�icr�h dxl�l�zQ�� �h<r�h<�~d��±�)�bqn/desth-p9i?gxd/y�lN�?h-sti?z�}Ch�h<��n9r5lNy dwsth-rk�9mNs{dPdesth��������?�����N�����5�tdxdxh5r#u�lN�{p9z*stiN�?h��<p9h�iN�?h�z�ic�� �gkh �?�th<�t��h#�2�tgxdxh�i?zC�±�a5( h5y�h<y }Ch5r�dwsti?d#dwsth�gxh der5iN�tgw�9de�9lN��lNp2�9m?lc���t�<p9h�l?dq�9z{h�gCstiN�?h iNp2r5h�i?z{j%}�h�h5��dwr�h�i?dkh�z�uP�9des�N������������?� r�h�gkdwrk�9��de�9lc��h5��-�j�y�h�uPs{�9�xsV�5�tdxg

i?d#gw�9dkh����dxl �<r�h�i?dkh-desth<�2r��{�{� ���th�gxdw�9�x|~j�h5�tz{g��±5± �QlNy�h-r�h�gkdwrk�9��de�9lc�»h5��-�j?y�h�gPstiN�?h�zQ�! ��5�{p9dejB�5�tdxde�2�tm�r5h�gxderx�9��dw�9lN��gw�9dkh�g-�th�iNr desth�h5�tz{g-lNn�lcp2�9m?lN�Q�t�5p9h�l�dq�9z{h5g�� -{lNr�des{�9g-r5h�i?gxlN�Ai�nqh�u

iNrx}{�9der5iNr5j �Q�t�5p9h�l�de�9z{h�g#¦9�tl�d�gwstlNuP��°�y�i j%stiN�?h dkl%}�h i?z{z{h�z�dkl�dwsth�h<�tz�lNn/desth�"���# gxh����th5�t��h?�

ú�ü

Page 18: q s q ->

Inv

Inv

Inv

Inv

Em

Cap

Inv Cap

Em

Cap

EmInvCap

Em

Em

Cap Em

Cap

X X

XX

X X

XX

X X

XX

Bq1->BLq3

Wq1->BRq2

Bq2->BRq2

q1 q3 L

q3

q3

q1 q2 R

q2

q2

Rq2 q2

q2

q2

R

LR

R R

R

RR

R

L

R

RL

L

R

L

LL

L

L

LL

LRRLR

Em

Em

Cap

Cap

Inv

Inv

Em

Cap

Cap

Em

Cap

EmInv

InvEm

Cap

X X

XX

X X

XX

Wq2->BLq1

Bq3->Halt

Wq3->BLq2

q1q2 L

q1

q1

Haltq3

Halt

q2 Lq3

Halt

q2

q2

R

LR

R

R

R

R

R

R

L L

L

L

L

LL

L

L

LR

R

L

ê�:=>C698;Eªú �/��4�D9EUú ��QSM^:=>SQC<W6PBRM=E&QSVa:b_WE&F�Í�D\:ØB;D�E&<PBgQÔ_ÔE�VaD9E Ç�Ç Òaý�?,ASB;D9:=<9EYV;8LA�<\Fa:=Va:=QC<�VLANT9M=ECÏ�Z�QSVaE VaDPANV�:=<@E�ASBaD�]PAN:=8Q�Ñ7QCM=:=>CQS<¦6`BRM=E&QCV;:Ø_ÔE&F�VaD\EdV;QC]�QCM=:=>CQ ?,ANVLB;D9E&F�A�F;ÈW?UTPQSMJBR6\V�Ñ58aQS?ÓV;D9E M=ERÑ5V�A�<P_�VaD9E T`QCVaV;QC?�QSM=:^>SQ ?,A�VRB;D9E&F�VaD9E FLAN?@EFaÈW?UT`QCM�BR69V1Ñ58aQS?�VaD9E 8;:^>SDWV�Ï

ú �

Page 19: q s q ->

Inv q1L R L L RR

óL LRR R q2 Rq1

InvCap XXq2L R RL LR RR L

Inv XXq2 RL RRRLL

InvR XXq2 RR LLRLRL

InvL R L R q2 L R

L R L R Inv q2 L RR

ê�:=>C698;E�ú�ý/��4�D9E�ÌP8;FaV�FaV;E&]UQ�ÑfV;D9E Ç%Ç Òaý�?�ACB;D9:=<9E�F;:^?U6\MØANVaE�_$QC<@A T9MbAN<9ß�VLAN]PESÏ � E&<PBRQ9_WE&F�V;D9E�Ì`8aFaV·caX�ÏÔó�FaD\Q�Í�F�VaD9E8aE�Fa69M=VYQNÑ%BRM=E�AHKW:^<\>�V;D9E�X Z�[ VRA�]`E�Í�:=VaD�� � ����ªAN<P_ ��� ������ ����E&<9Ê&ÈW?�ECÏ�4�D9E!Í�D9:=VaE�BRQCD\E&Fa:=KCE�E&<P_�:=FYF;]PEHBR: ÌJBãÑ5QS8VaD\E�FaÈW?UT`QCM Ò½F;VLANVaEdBgQC?UT9:=<PANVa:=QC<�3 � h�����j�AN<P_�?,ANVLB;D9E&FYAN<,QSM=:^>SQC<W6PBRM=E&QSVa:b_WEãE&<PBRQ9_W:=<9>UV;D9E�Va8RA�<9F;:=Va:=QC< � ��� ��� � �����FaD\Q�Í�<fhf:=<ÉFRBaD\E&?,ANVa:bB ÑrQC8a? h`VaQ�V;D9E@8;:^>SDWVdQNÑÃV;D9E@VRA�]`ECÏ �ÉFaD\Q�Í�F�VaD9EUM=:=>¦ANVa:=QC<àQ�Ñ�VaD9E�Va8LAN<9Fa:=V;:^QS<ÆQSM=:^>SQC<W6PBRM=E&QSVa:b_WEE&<PBgQÔ_Ô:^<\>UVaD9E Va8RA�<9F;:=Va:=QC< � ��� ��� � �����UV;QUVaD9E 69<9:bÎS69E FaV;:bBaßWÈ�E&<P_�BR8aEHA�VaEH_�:=<Æó�Ï�c�< ��hW<9QSVaE VaDPANV�VaD9E�_W:=8aE�BRV;:=QC<�Q�Ñ����� F �LBg69VaV;:^<\>ªAN8a? ��_WE�VaE&8;?@:=<9E&F�V;D9Ed_W:=8;E�BRVa:=QS<,QNÑfVaD9E D9EHAC_�hWV;D9E Fa]PASBR:=<9>�T`E&V�Í�E&E&< ����A�<P_�VaD9E :=<WKCA�8;:ØAN<WV�FaE�ÎS69E�<PBRE�|E�<PBRQ9_WE&F�VaD9E�<\E&ÍËF;VLANVaECh�VaD\E�T9MbACB;ßÉFaEHÎC6\E&<PBRE �aT`E&D9:=<P_��ÉV;D9E�D9E�AS_|E�<PBRQ9_WE&F�VaD\E,<\E&ÍqFaÈW?UT`QCM�A�<P_ÝVaD9E�Í�D\:^V;EFaEHÎC6\E&<PBRE�V;Q�VaD\E@8a:=>SD¦V!Q�ÑYVaD\E $ 8aE�BRQS>C<9:=V;:^QS<ÉFa:=VaE�E&<PBRQ9_WE�FUVaD9E�MØANFaV�F;ÈW?UTPQSM½Ï � F;D9Q�Í�F�VaD9E�BRM=E�AHKCA�>SEUQ�ÑYVaD\E ����FaEHÎC6\E&<PBRE�]98aQSVaE�BgVa:=<9>�VaD9E :=<WKCA�8a:bAN<¦V·FaE�ÎS69E&<`BRE ��Ï ��FaD\Q�Í�F%V;D9E :^<WV;8LA�?�QCM=E�BR6\MØAN8%BRM=QCF;698aE QNÑOVaD\E$X Z1[ìVRA�]`ECÏ � FaD\Q�Í�FD9Q�ÍÉV;8aE�ANVa?@E�<¦V7Í�:=VaD �� � ����� ������� ����� ��E&<9Ê&ÈW?�E%ERÕ�E�BRV;F%V;D9E�ERøPBR:=Fa:=QS<�Q�Ñ�VaD9E�MbA�F;VOF;ÈW?UTPQSM½Ï � F;D9Q�Í�F7VaD9E�BRÈ9BRM=:=Ê�A�V;:^QS<Q�Ñ7VaD9E!VLA�]`E VaQ�Ñ5QS8a?�V;D9E�<9EgøÔV�caX�Ï

ú�û

Page 20: q s q ->

CT

GACATGT

GTACATG

ACTTTGT

AAACA

TG

AC

TTAAG

AATTC

CT

GA

GCATG

CGTAC

W

B

êf:=>S698aEUú � � Ç MbACB;ß,AN<P_UÍ�D\:^V;E FaÈW?UTPQSM=F%ERø9]98;E&FaF;E�_ A�F�8aEHA�MOX Z1[�Ï

GGATGNNNNNNNNNCCTACNNNNNNNNNNNNN

NNNNNN NN

Sta: Fok ICTGGAGNNNNNNNNNNNNNNNNGACCTCNNNNNNNNNNNNNN

NNNNNN

X: Bpm I

NNGAGGAGNNNNNNNNNNCTCCTCNNNNNNNN NNNN

GACGCNNNNNCTGCGNNNNNNNNNN

NNNNNNN NN

GCAATGNNCGTTAC

NNNNNN

GCAGCNNNNNNNNCGTCGNNNNNNNNNNNN

NNNNNN NN

Inv: BseR I

Cap: BsrD I

Sta’: Hga I

Em: Bbv I

ê�:=>C698;E�ú /�Ö4�D9EY8;E&FaV;8a:bBRVa:=QS<@E&<9Ê�Ȧ?�E&F�69F;E�_U:=<UA�X Z�[À47698a:=<9> ?�ACB;D9:=<9ECh�V;D9E&:=8�8;E&FaV;8a:bBRVa:=QS<@Fa:=V;E&F�h9AN<P_�V;D9EYQ�KSE&8aD`A�<9>SFVaD\E&ÈÆ>SE&<9E&8RA�V;ECÏ �� h � ��`h�$�h ��� ��hfAN<P_ �����AN8aE�69FaEH_ÉVaQ�:=?@]\M^E�?@E&<WV�VaD\E Ç%Ç Ò´ý�?�ACB;D9:=<9ECÏ � �� :=F�AN<�AS_9_W:=Va:=QC<`A�ME&<9Ê�Ȧ?�E 69FaE�_ÙVaQ�:^?�]9M=E&?@E�<¦V�Ð�:=<9F;ßWÈ � F � ø,üUI14YÐÉÏ

]`E&8�Ñ5QS8a? VaD9E!FLA�?�EdBRQS?@]96\VLA�V;:=QC<UT969V�: Ñ�_W: ÕJE&8;E&<WVYVRA�]`E&FYE&<`BRQ9_WE�_W: Õ�E&8aE&<WVã]98aQST9M=E&?@F�FaQS?@EYÍ�:=M=M`TPE�M=QSFaV�E&KSE&8aÈ�Va:=?@EVaD\E$BgQC?@]\69VLANVa:=QC<�:=FÃB;D9E�B;ßSE�_�Ñ5QC8 �� ����FaE�ÎS69E�<PBRE&FHÏ�crÑOA�T\:^QSVa:=<UMbA�T`E&MeI �YÍ�E&8aE :=<PBRQS8a]`QC8LANVaE�_�:=<WVaQ�V;D9E �� ����FaE�ÎS69E�<PBREVaD\E&<@F;Va8aE�]9VLAHKW:b_W:=<,BRQWA�V;E�_UT`E�AC_ÔFYBRQC69Mb_�T`E 69FaE�_�VaQ�8aE�BgQ�KCE&8�DPANM=VaE�_�?,ACB;D9:=<9E�FOT`ERÑ5QS8aE VaD\Edõ�Þ ù A�?�]9M=:­Ì�B&A�V;:^QS< FaVaE�]fÏâã<9M=ÈÉDPA�M=V;E�_ÉVRA�]`E&F@Í�QC69Mb_ F;Va:bB;ß|VaQ VaD\E,F;Va8;E&]9VLAHKW:b_W:=<ÀTPEHAC_WFUF;QÆ<9QÉ]`QC8;Va:=QC<¶Q�ÑYV;D9E�69<WÌP<9:=F;D9E�_¶VLAN]PE&F�Í%QS69Mb_ TPE8aE�?@Q�KCEH_�Ï

� Ä=��¾�� è+åì¾ Á ���|é ��å Å��àÁ ��ç|Ä Â�� � ¿É¿�� � Â�� �

ÚÉE�<9Q�ÍÉ>C:=KCE·8aE�ANM9FaE�ÎS69E�<PBREdAN<P_!8aE&F;Va8a:bBRV;:=QC<UFa:=V;EÃANFaFa:=>S<9?@E&<WV;FOV;QYV;D9E�FLB;D9E&?�A�V;:ØB#8aE&]98;E&FaE�<¦VRA�V;:^QS<@]98;E&FaE�<¦V;E�_:=<�eÔE�BRVa:=QS< � ÏUê�:^8;FaVHhfV;D9E�:=<WKCA�8;:bA�<WVYF;E�ÎS69E&<PBRE�F�h � A�<P_ � hfA�<P_àVaD\EUFaÈW?UTPQSM=F � AN<P_ � A�8aE@ANFaF;:^>S<9E�_ :=<Éêf:=>S698aE�ú � ÏZ�EgøÔVHh7VaD9E�8aE&F;Va8;:ØBgVa:=QC<¶Fa:=VaE&F!Ñ5QS8�VaD9E�E&<9Ê&ÈW?�E&F�h �Yö�� c&h �Ö��¯ c&h �%���;ù c&h �%�&° XÛc&h7A�<`_ �O�`© c�AN8aE,ANFaF;:^>S<9E�_ V;Q�VaD9E������� �� ���h � �����9h � ������� ����h����fh`A�<P_��� �� � ��� ���� � ��� � �ªF;E�ÎS69E&<PBRE�FU3½ê�:=>C698;E@ú Sj&Ï�4�D\E�69<\:ØÎS69E!FaVa:bB;ßWÈ�E&<P_WF>CE�<9E&8LANVaE�_ÝTWÈ �Ö��¯ c�BR69V;Va:=<9>�VaD\E@FaÈW?UT`QCM�FaE�ÎS69E&<`BRE&F@:=< E�ACB;DÉQNÑÃV;D98aE&E�_W: ÕJE�8aE&<WV Ñ58RA�?�E&F�A�8aEU>S:=KCE&< :=<�ê�:=>C698;E�ú��\Ï ASBaDUQ�KSE&8aD`A�<9>�:=F%_ÔE&Fa:=>C<\E�_UF;Q�VaDPANV�:=V�:=F%BRQS?@]9M=E&?�E&<WVLA�8;È VaQ <9Q�QSVaD9E&8�Q�KCE�8aDPAN<9>U35QS8%BRQS?@]9M=E&?�E&<WVfQ�ÑfA�<UQ�KSE&8aD`A�<9>WjA�V�?�QC8;EdV;DPA�<�V�Í�QU]PQSFa:=Va:=QS<9F�Ï·4�D9:=FdBRQS<9FaV;8LA�:=<WV�FaE�E&?@FãVaQUÍ�QC8aß�Í%E�M^M�:=<,>SE&<9E�BgQC<9F;Va8a6`BRVa:=QC<Àï�� ;ôaÏ�4�D9E Va8LAN<9Fa:=V;:^QS<VLANT9M=E�QSM=:^>SQC<W6PBRM=E&QSVa:b_WE&F�AN8aE@BRQS<9FaV;8a6PBRV;E�_ÉTWÈÉA�_W:=8aE�BRV!Fa69T9F;Va:=Va6\Va:=QC<ÉQNÑÃV;D9E@B;D9QCF;E&<ÉFaÈW?UT`QCM7FaE�ÎS69E�<PBRE&FHh�8aE�FaVa8;:bBRVa:=QC<E&<9Ê�Ȧ?�E FaE�ÎS69E&<`BRE&F�A�<P_�BRQSD9E&F;:^KSE�E&<P_�F;E�ÎS69E&<PBRE�Fd:=<WVaQUV;D9E FLB;D9E&?�A�V;:ØBgF�:^<�ê�:^>S698aEUú �9Ï2I �

� ÅÉç|å ÁàÄÉéæÅÆÂ�äWå ¾ è+åì¾ éÜÂ�� �

� :=KCE�<UE&<9QC6\>CDU8aE�FaVa8;:bBRVa:=QC<�E&<9Ê&ÈW?�E&F�hSÍ�:=VaDUM=QC<9>!E&<9QC6\>CDUQ�KCE�8aDPAN<9>CF%AN<P_�MbA�8;>CE�E&<9QS69>CD�FaE�ÎS69E�<PBRE&FãTPE&V�Í�E&E&<VaD\E&:=8O8;E�BRQS>C<9:=Va:=QS<�A�<P_�BRM=E�AHKCAN>CE�F;:^V;E&F�hWA�<WÈ 47698a:=<9>ã?,ASBaD\:^<\E#BgQC69Mb_ T`E�:=?@]9M=E&?UE&<WV;E�_ãÍ�:^V;D�QC6\8OV;E�B;D9<9:bÎS69ECÏ7c�<�8aE�ANM=:^V�ÈWhD9Q�Í�E&KCE�8�h�V;D9E�<W69?UT`E&8 A�<P_àKCA�8;:^E�V�È,QNÑÃBRMbA�F;F cacaeà8aE&F;Va8a:bBRV;:=QC< E&<9Ê&ÈW?@E�Fd:=F M=:=?@:=VaE�_�FaQ�QC<\M^È�F;?,A�M=M�47698;:^<\>@?,ASB;D9:=<9E&F?,AHÈãTPEYBgQC<9F;Va8a6`BRVaE�_ÖÏ�47Q FaD9Q�ͶVaDPANVO8;E&FaV;8a:bBRV;:^QS<UE&<9Ê&ÈW?�EÃB;D9E&?�:=FaVa8;È�:=F769<9:=KCE&8;FLANM½hNÍ�:^V;D9QC6\VOV;D9EY_WE&F;:=>C<�Q�Ñ�:^?�A�>S:^<`A�8aÈE&<9Ê�Ȧ?�E&F�h�Í�Eª_WE�?@QC<\FaVa8RA�V;E�V;DPA�V QC6\8�?@Q9_WE&M7B&A�<É:=?�]9M=E&?UE&<WV�VaD9EUF;?,ANM^M=E&F;VdI14YÐ�8;E&]PQS8aV;E�_�h�A � FaÈW?UTPQSM�hPü�FaVRA�VaE± � �P�9l?de�2���9gC�w�tgkd#i%n9�{�t��de�9lc�tiNp~mcr�lN�{��dwsti?dP}{�2�tz{gPgkdwr5lN�tmNp9j�dxl ic�tl?desth<r�n �t��dw�9lN�tiNp{mNr5lN�{��|��tlNuP�Vi?g#gkdwr5h5�tdxi ���9zQ�2�C�±5¤ ����dw�tiNp2p9j�� iN�Vh�¯Qder5i *����t�<p9h�l?dw�9z{hPge�ti?��h5rPsti?g#dxl�}Ch�i?z{z{h�z�}�h�dwu�h�h5��dwsth�gxj?y�}�lNpth�¯��<�9ge�9lc� gw�9dkh�g� ic�tz�desth gxde�9�x|{j�h5�tz "�� }Ch���iN�tgkh

� 351�b#h�¯Q�5�9gxh�gPi�p9lN�tm�h5rP�2�~dxh5r5�?h5�{�2�tm-gkh �?�th<�t��h-destiN���9gP�th���h�gkgxiNr5j dxl �<�td#lN�tdPdesth-p9i?gxd#gkj�y�}�lNpe�

���

Page 21: q s q ->

CATGT

GTACA

CATGT

GTACAG

TG

AC

AC

T AAACA

GT

CT

GA

CT

GA

CT

GACATGT

GTACAAAACA

TTTTG

NNNNNNN

NNNNNNNCCTAC

GGATG

CCTAC

A

TTTGT

TG

AC

CT

GACATGT

GTACANNNNNN

NNNNNN

AC

T AAACA

GT

AACA

CCTAC

GGATG NNNNNNNN

NNNNNNNN TTTTTT

NNNNNNNN

NNNNNNNNCCTAC

GGATG

GGATG

G

TG

ACTTTGT

AAACA CT

A

NNNNNNNN

NNNNNNNN

ACA

GTAGG

CATCC

CATCC

GTAGG

NNNNNNN

NNNNNNN

CT

GA

TACATG

ACTTTGT

AAACA

TG

ACTTTGT

AAACA GTACA

T

CT

GA

NNNNNN

NNNNNNGTAGG

CATCC

CATGT

GT

G

CATGT

CATG

G CT

GA

GCATG

CGTAC

TTAAG

TCAC

TNNNNNNNN

NNNNNNNN

GGATG

NNNNNN

NNNNNNCCTAC

GGATG

GGATG NNNNNNN

NNNNNNN

TG

ACAATT

AAT

TTAAG

C

CT

GA

GCATG

CGTAC

TAAG CT

GA

GCATG

CGTAC

TG

ACAATTC

T

CCTAC

CCTAC GTAGG

CATCCNNNNNNNN

NNNNNNNN

ATG CT

AG

TG

AC

GC

CGTAC

TTAAG

AATTC

TG

AC

TTAAG

AATTC CGTAC

G CATGCT

GA

NNNNNNN

NNNNNNN

CATCC

GTAGG

CATCCNNNNNN

NNNNNN C

GCATG CT

GACGTA

TTAAG

AATTC

TG

AC GTAGG

ê�:=>C698;E�úQ�/��âãKCE&8;DPA�<9>SF@>SE&<9E&8RA�VaEH_ÀÍ�D9E&<ÀT9MbACB;ß|AN<P_¶Í�D9:=VaE�FaÈW?UT`QCM=F�A�8;E�BR69V@TWÈÉV;D9E�� ������ÆBR69V;VaE&8 �Ö��¯ c�:=<Àý_W: Õ�E&8aE&<WV�FaVRA�VaEãÑ58RA�?�E&F�Ñ58aQS?ÓV;D9EYM=ERÑrVÃAN<P_!Ñ58aQS?ÛVaD9Eã8a:=>CDWV�Ï ASBaD�Q�KCE&8;DPA�<\>�:=F�69<9:bÎS69EdAN<P_�?@:=F;?,A�VRB;D9E&F7E&KCE�8aÈUQCV;D9E&8Q�KCE�8aDPAN<9> 35QC8�BRQC?�]9M=E&?@E&<WV�QNÑ1AN<ÆQ�KSE&8aDPAN<9>¦jã:=<ÉA�V M=E�A�F;V�V�Í%Q�]`QCF;:^V;:=QC<9FHϪZ1QCV;EUVaDPANV�VaD9EUQ�KSE&8aD`A�<9>SFYÑrQC8 FaVRA�VaE ���ACBgVa6PANM^M=È�:=<PBRM=6P_WE�úY<W6PBRM=E&QSVa:b_WEãQ�ÑfVaD\E �$<¦6`BRM=E&QCV;:Ø_ÔEd:=<WKCA�8;:bA�<WV7FaE�ÎS69E&<`BRE&F�Ï�4�D9:=F�:=FÃANM^8;:=>CDWV�ëÜVaD\E�:^<WKCAN8a:bA�<WV7FaE�ÎS69E�<PBRE:=F%8;E&>CE�<9E&8LANVaE�_àÍ�D9E&<�V;D9E�BRQC8;8aE�BRVãVa8RA�<9F;:^V;:=QC<@<W6PBgM^E�QCVa:b_WE :=F�AC_9_WEH_�Ï74�D9:=F�69FaE QNÑO]PAN8aV�Q�ÑfV;D9E :=<¦KCAN8a:bA�<WV�F;E�ÎS69E&<PBgEªANFFaÈW?UT`QCM`FaE�ÎS69E�<PBREUA�M=M=Q�Í�F%69F�V;QU?,ANßCE�VaD\E�FaÈW?UT`QCM=F�FaD\QC8aV;E&8�Ï

�9ú

Page 22: q s q ->

q1

q2

q3

q4

q5

q6

q7

q2

q3

q4

q7

q5

q3

q3

q6

q2

q1

q1

q1

q2

q2

q1

q3

q3

q4

q5

q5

q5

q6

q7

q7

q6

q4

q6

Halt

AL

OL

OL

IL

YL

AR

YR

IL IL

OL YL

AR

IR

IL

YR

YL YR

YL

YR

AL

AR

IR

IR

OR

YR

OR

IL

Y

O

I

A

ê�:=>C698;EUú�ü/�74�D\EdV;8LAN<9Fa:=Va:=QS<,VRA�T9M=EãÑ5QS8ÃÐ�:=<9F;ßWÈ � F � øÙüUI1<9:=KCE&8;FLA�M�47698;:=<9>�?�ACB;D9:=<9ECÏ

TCGTAC

AGCATGTTAAGG

AATTCC

TG

AC

CT

GA

AAACAG

TTTGTCCCATGT

GGTACATG

AC

CT

GA

AACGAC

TTGCTG

CCAATT

GGTTAA

TG

AC GA

CT

GTCTCA

CAGAGTGGAGCC

CCTCGG

TG

AC

CT

GA

Y

O

I

A

ê�:=>C6\8aEUú ��� � X Z�[ F;E�ÎS69E&<PBgE&F 69FaE�_àA�F�VaD\E�FaÈW?UT`QCM=F7Ñ5QS8YA�I14YÐÉÏ

?,ASB;D9:=<9E@BRQC<\FaVa8;6PBRV;E�_ÀTWÈ�ÐÙ:^<\FaßWÈÀ3½ê�:=>C698;EÆúHüCj&Ïà4�D9:=F�?�ACB;D9:=<9EU:=F�BRQS<9FaV;8a6PBgVaE�_+69Fa:=<9>àVaD9E � F;Ȧ?UT`QCM=F�F;D9Q�Í�<É:=<ê�:=>C698;E�ú �\Ïf4�D\E&FaE�F;ÈW?UTPQSM^F·DPAHKCEãVaD9EãFLA�?�EY]98;QC]`E&8aV�È�A�F�VaD9QSFaE�B;D9QCF;E&<�Ñ5QC8·VaD9E Ç 69FaÈ Ç E�AHKSE&8�?,ASB;D9:=<9ECÏ KCE&8;È�Ñ5QC6\8TPANFaE�Q�KCE&8;DPA�<9>@Bg8aE�ANVaE�_ TWÈ�A � ������8aE&F;Va8;:ØBgVa:=QC< E&<9Ê&ÈW?�E�?@:=Fa?�AHVLB;D9E&F�E�KCE&8 QCV;D9E&8ãFa6PB;DàÑ5QC698ãTPA�F;E�Q�KSE&8aD`A�<9>U:=<ÆANVM=E�A�F;V%V�Í�Q�]9MbACBRE&FHÏ2I�� �Ö��¯ c � F%BR69V;Va:=<9>UF;:^V;EdB&AN<@QS<9M=ÈUTPEãFaD9: Ñ5V;E�_�VaD98;QC69>SD@VaD\E&FaE FaÈW?UT`QCM=F � Va:=?@E�F�VaQ�ÈW:^E�MØ_ � _W: Õ�E&8aE&<WVFaVRA�V;E&F�Ï!4OQU:=?�]9M=E&?@E&<WV�VaD9E�8aE�?,A�:=<9:=<9>UýUF;VLANVaE&FHhOAN<ÆAC_9_Ô:^V;:=QC<PANM�E&<9Ê&ÈW?@ESh �ã»N� c&h`:=FY69F;E�_ A�F � �������Bg69VaV;E&8�Ï �Y»C� c?,ANßCE&F U<W6PBgM^E�QCVa:b_WE!Q�KCE&8;DPA�<9>SF 35F;E&E�8;E&FaV;8a:bBRV;:^QS<ÆF;:=VaE � �� :^< êf:=>S698aEUú Sj�VaDPANVdB&AN<�T`E�FaD9: Ñ5V;E�_�V;D98aQS69>CDÆýUBg69VaV;:^<\>Ñ58RA�?@E�F�:^<àVaD9E�>C:=KCE�<�FaÈW?UT`QCM=F�Ï Ç E�B&A�6\FaE@V;D9E�Q�KSE&8aDPAN<9>CF �ã»N� cYBR8aE�ANVaE&F�BRQC<WVLAN:=<�VaD9E � F;ÈW?UTPQSM�FaE�ÎS69E&<`BRE&F�69FaE�_à:=<VaD\E �f�H¯ c�Q�KSE&8aD`A�<9>SF�Ñ5QC8�FaVRA�VaE�F�úRáÔý�A�F�Fa6\T9FaE�ÎS69E�<PBRE&F VaD\E&È,ANM^F;Q�D`AHKCEYV;D9E ]98aQS]PE�8aV�È@V;DPA�V�A�<WÈU]PAN:=8�Q�Ñ7?@:=Fa?�A�VLB;D9EH_E&<P_ÔF�Í�:=M^M7DPAHKSE@A�V M=E�A�F;V ��?@:=Fa?�A�VRBaD\E&F�Ï![ËI�4YÐ FaQÆBgQC<9F;Va8a6`BRVaE�_¶DPANF � �Cü���� J�[�@V;8LAN<9Fa:=Va:=QS<ÆQSM^:=>SQC<W6PBRM=E&QSVa:b_WE&FHÏI�<ÔÑ5QC8;Va69<PANVaE&M=ÈWhW<9Q@BRQS69<WVaE&8;]PA�8;VdV;QUVaD9E�������� �� � �1ö)� c�ERø9:^F;VaF1Ñ5QC8 �ã»N� c&hWVaDPANV�:^FHh9V;D9E&8aE�:=F�<9Q��TPANFaE Q�KCE&8;DPA�<\>BR69V;VaE&8�VaD`A�V�8;E�BRQC>S<9:=Ê&E&FUA�_W: Õ�E&8aE&<WV�Fa:=VaE�Ñr8aQC? �Y»C� c�ÑrQC8�69F;EU:=<É]98aE&]`A�8a:=<9>àVaD9EUE&<`_ Q�ÑYVaD\QCFaEUQSM=:^>SQCF VaD`A�V�A�<9<\E�A�MFaÈW?UT`QCM=FdBg69V�TWÈÆF;VLANVaE&F \h��\hfA�<`_Éü9ÏUc�< QC8R_WE&8�V;Q�?,AN<¦6ÔѽACBRV;698aE�VaD\E&?ðÍ�EU?U69FaV E&:=V;D9E&8�F;Ȧ<WV;D9E&Fa:=Ê&E�TPQSVaDÉF;Va8LAN<P_WFERø9]9M=:bBR:=VaM=È/I���QC8�FaÈW<WVaD9E&F;:=Ê&E�VaD\E&? ANF%V�Í�Q�]PAN8aV;F�h9QS<9EYÍ�:=V;D,A!]98aERÒaBR69V �ã»N� c�8aE&F;Va8a:bBRV;:=QC<�Fa:=VaESh9A�<P_�VaD9E QCV;D9E&8�Í�:=VaD,AN<69<PBg69V �ã»N� c�8;E&FaV;8a:bBRV;:^QS<�Fa:=V;ECh9V;DPA�V�?�AHÈ�T`E M^:=>WA�VaEH_@V;QC>SE&VaD9E�8�Ï

� èÀä\ÁYÅÆéæÁãÁ%ä\çÝå

� ��� � @/@/�%@ !#��@/@���!P)/.���04�D9E&8;E�A�8aEã?,AN<¦È!ÍÃAHÈWF·Ñ5QC8�V;D9E»��B;D9E&?�:ØB�A�M9F;VaE&]9F�QS69VaM=:=<9E�_�?,AHÈ Ñ�A�:=M�Ï�ÚÉE�DPAHKCEãM=:^F;VaE�_�VaD9Eã?@QSFaV�:=?@]`QC8;VLAN<¦V

E&8;8aQC8ã?@Q9_WE&F�A�<`_@F;Va8RA�VaE�>C:=E&F�ÑrQC8�VaD9E&:=8ã?@:=<9:=?U:­Ê�ANVa:=QC<�T`E&M=Q�ÍA�±;' �Psth�gxh����th5�t��h�gCnqlNr�dwsth�gxj�y }ClNp9g���iN�tz�� iNr5h-r�h�iNp2p9j-�e�tgxd#desth-gkh �?�th<�t��h�g�nolcr� iN�tz� p9h�gkg#dwsth5�2r#��h<�~dwr5iNptdeuPl����t�<p9h�l?dw�9z{h�g5�±;, -{lNr�dwsth�l�desth<r�dwr�ic�tge�9dw�9lN���Q�t�5p9h�l?de�9z{h�gCuPs{�9�xs��tgkh��/����bPgw�9dkh�g�dxl h<�t��lQz{h#gkdxi?dxh#u�h��th�h�z�gxj?�{desth�ge� -�h#lN�{p9j�lN�th�gxder5iN�tz�iN�tz,+{p2p{�2�»dwsth

l?dwsth5r�uP�9dwsA���-����lNp9j�y�h5r5i?gxhN���[r5iN�tge�9dw�9lN��lNp2�9m�lN���t�<p9h�l?dw�2z{h�g/dwsti?d#y�iNj�}Ch y�iN�Q�{noi?��de�{rkh�z��2�Adws{�9g�uPiNj�stiN�?h�dwsth i?z{z{h�zBi?z{�NiN�~dxi?m?h-lNn}�h<�2�tm�iN}{p9h dxl�}Ch��<p9lN�th�z%�2�{dkl%�{p9i?gwy��9z{g/lNr���lN�{�9h�z%}{j � � ( �

���

Page 23: q s q ->

�Rñ�� �f��«b�=�L��� «=»C�H��«5���W�â B&B&ANFa:=QC<PANM=M^ÈãM=:^>WA�F;EOÍ�:=M=MHѽAN:^M�V;QO×RQS:=<YV�Í�QYBRQCD9E�Fa:=KCE�E&<P_WF7A�<P_$Í�:^M=M�:=<9F;VaE�AS_ M=E�AHKCE�A�]9:=E�BRE�Q�Ñ9M=:=<9E�AN8fXdZ1[�Ï�4�D9:=F

DPAN]9]PE�<9Fd_W6\8a:=<9>�VaD9E�EgøÔEHBR69Va:=QS<,QNÑOQS698YX Z�[ 47698a:=<9>�?,ASB;D9:=<9E�: Ñ#A�Va8RA�<9F;:=Va:=QC<�QCM=:=>CQC<W6PBgM^E�QCVa:b_WE�:=F�<9QSV�:=<PBRQC]`QC8RA�V;E�_:=<@F;VaE&] �9hSQC8�QC<\EYQ�Ñ7VaD9E BR:=8LBR6\MØAN8a:=Ê�ANVa:=QC<9F�:=<@F;VaE&] � QC8��ãѽA�:=M=F�Ï�4�D9E �L_ÔERÑ5E�BRV;:=KCE ��M=:^<\E�A�8�VLAN]PE&F�Í�D9:bB;D@8;E&Fa69M=V�?�AHÈ�TPE�LB;D9E�Í%E�_�69] ��Í�:=VaD@A�X Z�[æERø9QC<W6PBgM^EHA�FaEãM=:^ßSE ø9QC<W6PBRM=E�ANFaEãcacac&Ï9X Z1[ ø9QC<W6PBRM=E�ANFaEãcacac·QC<9M=ÈUB&A�VRA�M=ÈWÊ&E&F�VaD9Eã8aE&?�Q�KCA�MQ�ÑfX Z�[¶Ñ58;QC?ÓAN<�QS]PE�<@ý��WE&<P_�F;Q�VLAN]PE&F·VaDPANVOD`AHKCE�BRM=QCFaEH_UBRQC8;8aE�BRV;M=ÈUÍ�:^M=MWT`E�8aE&F;:^F;VLAN<¦V·VaQ�BRM=E�AHKCA�>SECÏ�4�D9:=F#ANM=FaQ ?@E�AN<9FVaD`A�V�: ÑfM=:=>¦A�F;E%?�A�<PAN>CE&F7V;Q�?,ANßCE�QC<9EãQ�Ñ�VaD9EãV�Í%Q�BgQ�KCA�M=E&<WV�T`QC<P_WF·<9E&E�_WEH_@V;Q�FaEHA�M�A�<9<9EHA�M=E�_UF;Va:bB;ßWÈ�E&<`_WF%:=<UQS698�VLAN]PEVaD\E&< ø9QS<¦6`BRM=E�A�F;E@cac;c�B&A�<¶QC<9M=ÈÆ_W:=>SE&FaV�VaD9E�FaV;8LA�<`_ÉÍ�:=VaDÉV;D9EU<9:bB;ßJÏ�ê\698;VaD9E&8�Va8;E�A�V;?@E&<WV�Í�:=V;D|A�Fa:=<9>SM^EgÒ½F;Va8LAN<P_WE�_<W6PBRM=E�ANFaE�F;6PB;DÙANFYe�ú Í�:=M=MPT`E�<9E�BgE&FaFRA�8aÈàVaQ@_WE&>S8LAS_WE VaD9E�QSVaD9E�8YBRQ�KCA�M=E&<WVaM=ÈSÒaBRM=QCFaEH_UFaV;8LAN<P_�Q�Ñ7VaD9E�_9A�?�A�>CEH_�VLA�]`ECÏ�Rþ���� �P²R��°&°R�L²g�%� «=»N���½«r���W�

X Z�[qM=:=>¦ANFaE,B�A�<fh·69<P_WE&8�BRE&8;VLA�:=<ÜBRQS<P_W:=Va:=QC<\F�h�M=:=>¦ANVaE�?@:=Fa?�A�VLB;D9EH_�]PAN:=8aFUQ�Ñ FaV;:ØB;ßWÈ|E�<P_WF�ï � 7*Wôa϶4�D9E&FaE:=<PBRQS8a8aEHBRVYM=:=>¦ANVa:=QC<9F�B&A�<�QC<\M^ÈUQ9B&Bg698Y:=<@QS698YX Z�[æ47698a:=<9>�?,ASBaD\:^<\EY_W698a:=<9>UF;VaE&] �UAN<P_U?�AHÈ�DPAN]9]`E&<�:^<�QC<9E QNÑOV�Í�QÍ�AHȦFHÏ�ca_WE�<¦V;:bB&A�M7BRQC]9:=E&FãQ�Ñ%A�< ������ ��� ���UFaVa:bB;ßWÈ@E&<`_�?,AHÈ�TPE!M^:=>WA�VaEH_�3�BR8aEHA�Va:=<9>�A�?@:=Fa?�A�VRBaDUA�VãQC<9E ]`QCF;:^V;:=QC<Pj�QS8A�<à:^<`BRQC8;8aE�BRV QSM^:=>SQC<W6PBRM=E&QSVa:b_WE Va8RA�<9F;:^V;:=QC<�?�AHÈUTPE�×RQC:=<9EH_@V;Q@V;D9E�E�<P_�M=ERÑ5VãT¦È�V;D9E � ������ªBR69V;VaE&8 E&<\Ê&ÈW?@EU3�BR8aE�ANVa:=<9>?@:=F;?,A�VRB;D9E&F%ANVÃANV�M^EHA�FaV�V�Í�Q�]PQSFa:=Va:=QC<\FLj&Ï74�AN]PE&F�Í�:=V;D@Fa6`BaDà?@:=Fa?�AHVLB;D9E&F%B�A�<�TPE�_WE&VaEHBRVaE�_Ù69Fa:=<9>@A!Fa:=<9>SM^EgÒ½F;Va8LAN<P_WE�_<W6PBRM=E�ANFaE�Fa6`BaD�A�F7<W6PBRM=E�ANFaEYe�ú�ï¹þ 3�ô9Í�D9:bB;D@BRM=E�AHKCE�F%_WQC6\T9M=ERÒ½F;Va8RA�<P_WEH_UXdZ1[ÜA�V�V;D9E�Fa:=<9>SM^EgÒ½F;Va8LAN<P_WE�_�8;E&>C:=QS<9F7:^<`_W6PBRE�_TWÈU?@:=Fa?�AHVLB;DfhHQC8�B;D9E&?�:ØB�A�M98;E�A�>SE&<WVaF�Fa6`BaD�ANF�DWÈÔ_Ô8aQHø9ÈWMØAN?@:=<9E�QC8�QSFa?�:^6\?iVaE�Va8aQHø9:b_WEãVaDPANV%?�QÔ_Ô:­ÑrÈd?�:=Fa?,ANVLB;D9E&F�AN<P_?,ANßCEUV;D9E&?�F;69FLBRE�]9Va:=T9M=E�VaQÉBRM=E�AHKCA�>SE@TWÈÉ]9:=]`E&8a:b_W:=<9E ï � �\ô´ÏÉâã<PBRE�V;D9E�_WERÑ5E�BgVa:=KCE�VLAN]PE�FUDPAHKCE�TPE&E�< :b_WE�<¦V;: ÌPE�_ÉTWÈM=:=<9E�A�8;:=Ê�A�V;:^QS<fhSFa69T9F;E�ÎS69E&<WV Va8;E�A�V;?@E&<WV�Í�:^V;D ø9QC<W6PBRM=E�ANFaE�c;cac�B&A�<�8aE�?@Q�KCEãVaD9E�?�Ñ58;QC?�V;D9E�BRQS?@]96\VLA�V;:=QC<fÏ����� �f��«b�=�R�U°L�g�R�½°�«5²R��«5�N�W�

ù E�FaVa8;:bBRVa:=QC<@_Ô:^>SE&FaV;FÃAN8aE�<9QSV%A�M=Í�AHÈWFOBRQS?@]9M=E&V;ECÏf[1Ñ5VaE�8�FaV;E&]9F�úChSý9hWA�<P_� FaQS?@E�Q�Ñ�VaD9E X Z�[ÀVLAN]PE&F�?,AHÈ F;Va:=M=MB&AN8a8aÈ�V;D9E�D9E�AS_ 3 �����,AN<P_ � � Wj�h)����ÖhWQS8 $�8aE&F;Va8a:bBRV;:=QC<�F;:^V;E&F�h`8;E&Fa]`E�BRV;:^KSE&M=È¦Ï Ç ERÑrQC8aE!VaD9E�BgQC?@]\69VLANVa:=QC<�B&A�<�]98;QÔBgE&E�_VaD\E&FaE@_WEgÑ5E�BRV;:^KSE�VRA�]`E&F�?U69F;V�TPE�8aE�?@Q�KCEH_�Ñ58aQS?ËV;D9E�8aE�ASBRVa:=QC< ?@: ø9Va6\8aE�V;Q@ßCE�E&]ÆV;D9E&? Ñ58aQS?Ë:=<WVaE&8´Ñ5E&8;:^<\>,Í�:=V;D�MbA�VaE�8FaV;E&]9FHÏ

� 6\FaV�ANF$A�T9:=QSVa:=<ÆMbANTPE&M7:=<PBRQS8a]`QC8RA�VaEH_ :^<WV;QÙA ������,F;E�ÎS69E&<PBgE,?�AHÈ@T`EU69FaEH_ VaQ�8aE&?�Q�KCEUX Z�[ÛVLAN]PE&F!VaDPANVDPAHKSE�ÌP<\:^F;D9E�_ BRQC?�]969V;:^<\>Ph9T\:^QSVa:=<�I�� QS8YQCV;D9E&8�_Ô:^F;Va:=<PBRV 8;E&]PQS8aV;E&8�?@QSM=E�BR69M=E&Fã?@:=>CDWV�T`E�69F;E�_àVaQ�?,AN8aß,AN<P_à8aE&V;8a:=E&KCEVLAN]PE�F�Ñ58;QC?)Í�D9:bB;DÉVaD9EUD\E�AC_�h�����fhfQS8 $ Fa:=VaE&F�DPAHKSE�ѽA�:=M=E�_ VaQàTPE@BR6\V�Ï øÔV;8LAà<W6PBRM=E&QCV;:b_WE&F�B&AN<|T`E,AS_9_WE�_ÉANV�VaD9EE&<P_ÙQ�Ñ�VaD9E �����FaE�ÎS69E&<`BRECh�TPE&V�Í�E&E&< VaD\E�TPACB;ß�VaQUT`ACB;ß � ������� ���UA�<P_�� �������8aE�BRQS>C<9:=V;:^QS<�Fa:=V;E&F�h`QC8�T`E&V�Í�E&E&< VaD9ETPASBaßUV;Q�T`ACB;ßUQ9B&BR698;8aE&<PBgE&F Q�ÑfVaD\E �� �� � ��� ���� � ��� � �$8;E�BRQS>C<9:=Va:=QS<UFa:=VaE&F�V;QªB�A�8a8;È@V;D9EY8;E&]PQS8aV;E&8Y>S8aQC6\]9F�Ï7[1Ñ5VaE&8�E�ASBaD8aE�FaVa8;:bBRVa:=QC<�A�M=MPX Z�[ÀVRA�]`E&F%Í�D\:ØB;DUF;Va:=M=M9DPAHKCE�V;D9EY8;E&]`QC8aV;E&8ã35Í�D9:bB;DUFaD9QS69Mb_�DPAHKCE�T`E&E&<�BRM=E�AHKCEH_�:^<UV;D9E�MbA�F;V�FaV;E&]Pj·?,AHÈ8aE�?@Q�KCEH_U69F;:^<\>@A �@<9:=V�ÈUBaD\8aQC?�A�V;QC>C8RA�]9DWÈWÏ

4�D9E&8;E%:=F�<9QYF;D9QC8;VLA�>SE%QNÑP_W:=FaVa:=<PBgVO8;E&]`QC8aV;E&8�?�QCM=E�BR69M=E&F�Í�:=V;D�Í�D9:bB;D�VaQã?,A�8;ßYV;D9E%ýY_Ô:­Õ�E&8;E&<WVfÑr69<PBRV;:^QS<PA�MS]PA�8;VaFQ�Ñ�A�Va8RA�<9F;:^V;:=QC<@QSM=:^>SQC<W6PBRM=E&QSVa:b_WECÏ7Þ�D9QSM^E�FaVaE�8aQCM�h �P69QC8;E&FLBgE&:=<fh�A�<P_�_W:=<9:=Va8;QC]9D\E&<WȦM�>S8aQS69]9FYA�8;E�A�M=MfAHKCA�:=MbA�T9M=E�Ñ5QS8Ã_Ô:^8;E�BRV:=<PBRQS8a]`QC8LANVa:=QC<É:=<WVaQàQCM=:=>CQC<W6PBgM^E�QCVa:b_WE�FYÑr8aQC? ���=���W�a�R²R� ï � �=ôaÏ�4�D9E@MbANVaVaE�8�V�Í�Q�?,AHÈ�T`E@8;E&Va8;:^E�KCE�_¶Í�:=VaD|AN<¦V;:=TPQ9_W:=E&FHÏeW:=<9>SM^EgÒ½F;Va8LAN<P_WE�_ÙQCM=:=>CQC<W6PBgM^E�QCVa:b_WE�F �;Fa:b_WE�B;DPA�:=<9F �U?,AHÈUA�M=FaQUT`E�:=<PBRQS8a]`QC8LANVaE�_Ù:^<WV;Q�V;D9E�Va8RA�<9F;:=Va:=QC<�QCM=:=>CQS<W6PBRM=E&QCV;:b_WE&FÍ�:=VaD�VaD\E�69FaE!Q�Ñ�T98LAN<PB;D9E�_�]\D9QCF;]9D9QC8RA�?�:Ø_Ô:^V;E&F�Ï�âãM=:=>CQS<¦6`BRM=E&QCV;:Ø_ÔE&FYBRQC?�]9M=E&?@E�<¦VRA�8;È�V;QUVaD9E&F;E�F;:b_WE�B;DPA�:=<9F�Í�QC6\MØ_�TPE69F;E�_�VaQU8;E&?@Q�KSE�VLAN]PE&FãÍ�:=VaD�ѽA�:=M=E�_�M^:=>WA�Va:=QS<9F%A�M=M=Q�Í�:=<9>�A!KW:^8;Va6PANM=M^ÈU:=<WÌ`<9:=VaEYKCAN8a:=E&V�È�Q�ÑO8;E&]`QC8aV;E&8Y?�QCM=E�BR6\M^E�F�Ï�� � � �`²L�N°&°L�R²g�ðR�R�R��°&«5²g�½«r���W�

8;8aQC8;F%:=<�Í�D9:bB;D@AY8;E&FaV;8a:bBRV;:^QS<@E&<\Ê&ÈW?@EYBR69V;F%X Z�[ìANV%AãFa:=VaE�QSVaD9E�8%V;DPA�<U:=VaF78;E�BRQC>S<9:=Va:=QC<UF;:=VaEYA�8;E�ERø9Va8;E&?@E&M=È:=<WÑ58;E�ÎS69E&<WV�A�<P_�D`AHKCE�<9QSVYT`E&E&<ÉÍ�E&M=M�ÎC6`A�<WVa: ÌPE�_,Ñ5QC8 A�M=Mf8;E&FaV;8a:bBRVa:=QS<ÆE&<\Ê&ÈW?@E&FHÏ ÚÜD9E&<�8;E&FaV;8a:bBRV;:^QS<ÉE&<9Ê&ÈW?�E&Fd_WQ�BR69V:=<PBRQS8a8aEHBRVaM=ÈÉ:=V�:=F�6\<P_WE&8�<9QC<ÔÒ½F;VLA�<`_9A�8R_É8aEHACBRV;:^QS< BRQS<P_W:=Va:=QS<9F�A�<`_É>CE�<9E&8LANM=M^È Q9B&BR698;F@A�V�FaE�ÎS69E�<PBRE&F�BRM=QCFaE�M^È 8aE�MØANVaE�_VaQàVaD9E&:=8�8aE�BgQC>C<\:^V;:=QC< FaE�ÎS69E&<`BRE|ï�� � þ$ô´Ï�4�D9:=F�?�E�A�<9F!:^V :=F�>SQ¦Q9_ ]98RACBRV;:bBRE@V;Q�8a69<¶8aE&F;Va8;:ØBgVa:=QC<¶8aE�ASBRVa:=QC<\F�:=<ÉVaD\E&:=8Fa6\>C>CE�FaVaEH_ÉT96WÕ�E&8;F�A�<P_àVaQ�?�:^<\:^?�:­Ê&E V;D9EUFa:=?@:=MbA�8;:=V�ÈUTPE&V�Í�E&E&<ÀA�]PA�8;Va:bBR69MbA�8 8;E&FaV;8a:bBRVa:=QS<ÉFa:=VaE@AN<P_�V;D9E@X Z�[ÛÍ�D9:bB;DFa6\8a8aQS69<P_WF�:=V�ÏÀeWVa:=M=M�h�VaD\:^FUE�8a8aQS8U?@Q9_WE�8aE�ANM^M=ÈÉÍ�QC69Mb_ÝDPAHKCE�VaQÉT`E�ERø9]9M=QC8;E�_¶ERø9]PE&8;:=?@E&<WVLANM=M^ÈÉ6\<P_WE&8UV;D9E�8aEHACBRV;:^QS<BRQS<P_W:=Va:=QC<\F�69FaE�_�Ñ5QS8�VaD9E�X Z�[ 47698;:=<9>�?�ACB;D9:=<9ECÏ� � � «º©ª��°&« � �H��«5�N�Æ�54ã�a�R�9�R�����W°&«º�W»�²�:C²��­« � �H��«5�N�W�± 3 ���tm?m?h�gxdxh�z }{j���i?zQrx�9iN� �Qh�h5y�ic�/���Ch5r5gklN�ticp~��lNy�y �{�{�9��i?dq�9lN�C�

�Cý

Page 24: q s q ->

Restrict Ligate

ê�:^>S698aEUúHû/��X Z�[æ8aE&F;Va8;:ØBgVa:=QC<ÆAN<P_�M=:^>WA�V;:^QS<UQC<�FaQCM=:b_�Fa69]\]PQS8aV�Ï

c�<¶3 Ç j Í%EU_WE&FRBR8a:=T`E@E&8;8aQS8aF�:^< Í�D9:bB;DÆM=:=>¦ANFaE�_ÔQ¦E�F�VaD9E �;Í�8aQS<9>�VaD9:=<9>��,A�<`_�×RQS:=<9F V�Í%Q�69<9?,ANVLB;D9E�_àFaV;:bBaßWÈE&<P_ÔF�Ï%î1E&8aE M=:=>¦ANFaEd_ÔQ¦E�F�VaD9E �a8a:=>SD¦V�VaD\:^<\>���AN<P_UM=:=>¦ANVaE&F�?,ANVLB;D9E�_�E&<P_WFHhWT969V�Í�EdB;D9QWQCF;EdV;Q�:=<WVaE�8a]98;E&V�:=VÃANFYA�<UE&8;8aQC8HÏÚÉE�DPAHKCEUA�M=8aEHAC_WÈ�?�E&<WVa:=QC<\E�_�VaD\EU]98a:=?,AN8aÈ�?@E�AN<9FãÑ5QC8 ßCE�E&]9:=<9>�V�Í%Q�_W: Õ�E&8aE�<¦V�XdZ1[ÛVLA�]`E&F�Í�:=V;D�BRQS?@]9M=E&?�E&<WVLAN8aÈE&<P_ÔF�Ñ58aQS?ì×RQC:=<9:=<9>�_W6\8a:=<9>�VaD9E 8aEHBRÈ9BRM=:^ÊHA�Va:=QS<,F;VaE&]\F � AN<P_���ë V;D9EY8;E�ACBgVa:=QC<9FYAN8aE 8a6\<,6\<P_WE&8�KSE&8aÈ@_W:=M=69V;EdBRQS<P_W:=Va:=QC<\FFaQUV;DPA�V A�<WÈ@?�QCM=E�BR6\M^EãQ�Ñ�XdZ1[ �;FaE&E&F �@:=VaF�Q�Í�<�BRQSD9E&F;:^KSE�E&<P_Ù?@QC8;E Q�Ñ5V;E&<�VaDPAN<,V;D9QCF;E�Q�Ñ�QSVaD9E&8;F�ï 8�WôaÏ�ê9QS8�Fa:=?@:=MbA�88aEHA�FaQS<9F FaD9QS8aV;E&8dX Z�[ VLAN]PE&F�3�A�F�M=QC<9>@ANFYV;D9E&È�A�8;E�<9QCVãVaQWQUFaD\QC8aV A�<P_ÙFaVa: Õ%j�Í�:=M=MfA�M=F;Q@BRÈ9BRM=:^Ê�E�TPE�VaVaE�8�VaDPAN<�M^QS<9>CE�8�PQS]9]9:=E&8dX Z1[iVLAN]PE�F�ï � �HôaÏ�âã<9E�_WE�Fa:=>C<ÆBgQC<9F;:Ø_ÔE&8LANVa:=QC<�V;DPA�Vã?U69FaV�T`E�?�AC_WEãÑ5QS8�FaD9QS8aVaE�8$X Z1[iVLAN]PE�FY:=FYV;QUE&<9Fa6\8aEVaD`A�V�VaD\E�<W69?UTPE�8%QNÑOD9E&M=:bB&ANMfVa6\8a<9F�:=<�VaD9E�X Z�[ VRA�]`E�AHÑrVaE&8�F;VaE&]9F � A�<P_ ��:=F�:=<WVaE&>S8LA�M�ï 8 �`ôaÏ74�D9:=F�>C6PAN8LAN<¦V;E&E&FãVaDPANVVaD\E,BR:=8LBg69MbA�8a:=Ê&EH_ X Z1[Ë:=F�69<\FaVa8RA�:=<9E�_ÀAN<P_ 69<9F;69]PE�8LBRQS:^M=E�_ÖÏÉ47Q�Ñ5698;VaD9E&8U]\8aQC?�QCV;EU:^<WV;8LA�?�QCM=E�BR6\MØAN8�BRM=QCFa6\8aE@QNÑYVaD9EX Z�[ VRA�]`E&F�Í%E ?�:^>SDWV�69FaE�AN<¦È�Q�Ñ�A�<W69?UT`E&8�Q�Ñ#X Z1[ T9:=<P_W:=<9>�]98aQSVaE&:=<9F�M=:=ßCE B&A�VRA�T`QCM=:=VaEdASBRVa:=KCANVaQC8�]98;QCVaE�:^< 3�Þ�[dõ�jVaD`A�VYA�8;E ߦ<\Q�Í�<,V;Q�T`E&<P_àXdZ1[iA�<P_�]98;QC?�QCVaEYBgÈÔBgM^:=Ê�ANVa:=QC<Éï� WôaÏ

� �<; Á�����.�� �C(�&B&A��@C)Ð�AN<¦È¶FaÈWFaV;E&?@FUD`AHKCE�TPE�E&<ì_WE&KSE&M=QC]`E�_¶Ñ5QS8�V;D9EÆBRQ�KCANM=E&<WVªANVaVLASB;D9?@E&<WVUQNÑ$X Z�[qV;QÉFaQCM=:b_ÉF;69]9]`QC8;V�3Lï ��Wôah

ï � ÿSô´h�ï � ��ô5j&Ï74�D\E�TPE�<9ERÌPV;FdQNÑO]`E&8�ÑrQC8a?�:=<9>ªX Z1[iBaD\E&?@:=FaV;8aÈ�QC<�FaQSM^:b_�Fa69]9]`QC8;VdAN8aE V�Í%QNÑ5QCMb_�Ï�ê�:=8aF;V�h\VaD9E�BRM=E�AN<¦6\]�Q�ÑFa6`B&BRE&F;Fa:=KCE@B;D9E&?�:bB&A�M�F;VaE&]9Fã:=FY>C8;E�A�V;M=È@Fa:=?�]9M=:­Ì`E�_�Ï ù EHA�>CE�<¦V;F�?,AHÈUT`E�A�]\]9M=:^EH_,AN<P_�VaD9E�<�Fa:=?@]\M^È�Í�A�FaD\E�_�Í�AHȦϷ4�D9EX Z�[ <9E&E�_à<9QCV�T`E�8aE&]98;E�BR:=]9:=VLANVaE�_ A�<`_�8a69<àQC<�AU>SE&MfV;Q@FaE�]PA�8RA�VaE�:=V�Ñ58aQS?ËV;D9E�E&<9Ê&ÈW?@E�FYQCM=:=>CQS<W6PBRM=E&QCV;:b_WE&F�69F;E�_�:=<VaD\EYMbA�F;V�FaV;E&]fÏ%eÔE�BRQC<`_�hWFaQSM^:b_!Fa69]\]PQS8aV�B&A�<�ERÕJEHBRV�VaD9EãFaE&]`A�8LANVa:=QC<�Q�Ñf_W: ÕJE�8aE&<WVYX Z�[ÜVRA�]`E&F�T¦ÈU?�A�:=<WVLAN:^<\:­<9>ãVaD9E&?�ANVA!M^Q�ÍÜAN<P_�BRQC<9F;VLAN<¦V�BRQS<PBRE&<WVa8RA�V;:^QS<fÏ�4�D\:^F�]PAN8aVa:bANM^M=È�FaQSM^KSE&F�VaD9E ]98;QCT9M=E&?�QNÑOVRA�]`E$_Ô:^?�E&8a:=Ê�ANVa:=QC<�Q�Ñ�eWE�BRV;:=QC<�ü9Ï=úChÔ3 jÍ�:=VaD9QS69V VaD9EU<\E&E�_ VaQ _W:=M^6\VaEUA�<P_à8aE�BgQC<PBRE�<¦V;8LANVaE�VaD9E@X Z1[ÓVRA�]`E&F�E&KCE&8;ÈÆcaX�Ï�4�AN]PE&F V;DPA�V�BgQC<WVLAN:^< E&8;8aQC8;F�A�8;EUM=E&FaFM=:=ßCE&M=ÈUVaQ�:=<WVaE&8RACBRVãÍ�:^V;D@QSVaD9E&8 BRQC8;8aE�BgVYVLAN]PE�FYFaQUV;DPA�V�V;D9E&:=8�8aE�?@Q�KCA�M`:=F�<9QCV�F;QU698a>SE&<WV�Ï

� DPAN<9> �R�,�N�­� D`AHKCE ]PE&8´Ñ5QC8;?@E�_ ?U69M=Va:=]9M=E@8;E&FaV;8a:bBRVa:=QS<9FÆA�<`_ÜM=:=>¦ANVa:=QC<9FUQS<ÜFaQSM=:Ø_ Fa69]9]`QC8;V�VaQ¶FaÈW<WVaD9E�Fa:=Ê&E?U69M=Va:=]9M=È�T98LAN<PB;D9E�_|X Z1[Ó?�QCM=E�BR6\M^E�F�Ï@âã698�47698;:=<9>�?,ACB;D9:=<9E�:=?@]9M=E&?UE�<¦VRA�V;:^QS<�8aE�ÎS69:=8aE�F�<9QSVaD9:=<9>�F;QÆBRQC?�]9M=ERøfÏ�[Fa:=?�]9M=E�M=Q¦QS]�E�<PBRQ9_W:=<9>�V;D9EYBRQC?�]969VRA�Va:=QS<�A�V;VLACB;D9EH_�VaQ�V;D9E�Fa69T\FaVa8RA�V;EYKW:bAdAãF;:^<\>CM=E�T98LAN<PB;D9E�_�×R6\<PBRVa:=QS<UÍ%QS69Mb_�F;6 �,BRECÏê�:=>C698;EªúHû�FaD9Q�Í�FãVaD9E!Fa6PB&BgE&Fa:=KCE�8aE�FaVa8;:bBRVa:=QC< A�<P_�M=:=>¦ANVa:=QC<UQNÑ��aE&ÈSE&M=E&VaF �@Q�Ñ�X Z�[iQS<�A�FaQCM=:b_UF;69]9]`QC8;V�ÏYXãE&V;E�BRVa:=QS<�Q�Ñ������UBRQS69Mb_UT`E$ASB&BRQS?@]9M=:=FaD9EH_�T¦ÈUÍ�A�F;D9:=<9> �PQS698aE�FLBRE&<WVãQC8�8LAC_Ô:^QSMbA�T`E&M=M^EH_�]98aQSTPE&F�ÑrQC8�V;D9E � �����FaE�ÎS69E&<`BRE�ACBg8aQCF;F�VaD9EFaQSM=:Ø_àFa6\]9]PQS8aVHÏ ù E&VaE&<WV;:^QS<ÉQ�Ñ�MbA�T`E&M�Í�QC69Mb_à:^<`_W:bB&A�V;EUVaDPANV�VaD9E@BgQC?@]\69VLANVa:=QC<�Í�A�F�_WQC<9E@AN<P_ 8aEHAC_WÈ VaQ�T`E,BRM=E�AHKSE�_Ñ58;QC?�V;D9E�FaQSM=:Ø_�Fa69]\]PQS8aV�Ï

� ��� Á�&A��!#.��»!#+-)/.���0B�� E&8;ÈÉM=Q¦QSFaEUE&F;Va:=?,ANVaE&F$Ñ5QC8�KCAN8a:=QC6\F �;DPA�8R_WÍ�A�8aE�Fa]`E�BR: ÌJB&ANVa:=QC<\F�� Q�ÑYQC6\8�X Z�[�47698;:^<\>�?,ASBaD\:^<\EªAN8aEU>C:=KSE&<

T`E&M=Q�ÍA��Rñ�� �P« � �

4�D9E�AN?@QS69<WV%QNÑ·X Z1[ 8aE�ÎS69:=8aEH_�Ñ5QS8YA �a69F;ERÑ569M ��BRQC?�]969VLANVa:=QC<�:=F�:^M=M Òa_WERÌP<9EH_�Ï�4�D9E&8aEgÑ5QC8;E�Í�E >C:=KCE�QS<9M=ÈUVaD9E?@QSFaV�TPA�F;:bB ?@E�ANFa698;E&FYQNÑ�Fa:=Ê&E Ñ5QS8�QC698ã:=?@]9M=E&?�E&<WVLA�V;:=Q�<UQ�Ñ%Ð�:=<9FaßWÈ � F�47698a:=<9>U?�ACB;D9:=<9EChWTPANFaE�_ÙQC<�VaD9E�ú���TPANFaE�]PAN:=8FaÈW?UT`QCM=F�69FaE�_ÙVaQU8aE�]98aE&F;E&<WV :^V;F � FaÈW?UT`QCMfA�M=]9D`A�T`E&V���ANVaQC?�F�ë �����A�V;QC?�F���T\:^VHGC?�A�F;F�ë 9Ï���ãßW> �N?@QSMPT9:=V;F�GWM=E&<9>SVaDWë�9Ϲü <9? ��T9:=VHG%KSQCM=69?�ERë �9Ï �<9? �+�NT9:=V�Ï2I #�4�D9E&F;EÆE�FaVa:=?�A�VaE�F,_WQÉ<9QSV@VRA�ßCEà:^<WV;Q|ACB&BRQS69<WV@V;D9E�Fa:=Ê&E QC8U?�A�F;FUQ�Ñ�VaD9EÍ�A�VaE�8�QC8 FaQSM=:Ø_ÙFa69]9]`QC8;V�69F;E�_ VaQ�?,AN:=<¦VRA�:=<@V;D9:=F�X Z�[�Ï ù E&FaV;8a:bBRV;:^QS<|_W:=>CE&F;VaF�A�8;EU<9QC8;?,ANM^M=ÈU]`E&8�ÑrQC8a?�E�_àÍ�:^V;D�X Z1[±;A ��gxge�{y��2�tm�� �-� �9g�i * �{y=uP�9z{h�¨ �����Q­"'x��j?p2�2�tz{h<r )Q�

� �

Page 25: q s q ->

BRQS<PBRE&<WVa8RA�V;:^QS<9FYA�8;QC69<`_�ú � >ªX Z�[ ���� � íàÍÃANVaE&8HÏ74�D9:=F%?�E�A�<\F%Í�EY8;E�ÎS69:=8aE�A�T`QC69V �t� ��Ð�� Q�ÑfÍ�A�V;E&8�VaQ�?,AN:=<¦VRA�:=<A�?@QSM=E�Q�ÑOT\:^V;F�ëÜQC8YANTPQS69V ú+�9ú&��V;D@VaD\E�KCQSM^6\?@E�Q�Ñ�A�<�QCM=ÈW?@]\:ØB·Fa:=Ê&EH_�FaÍ�:=?@?�:=<9>Y]`QWQCM�Ïî�Q�Í T9:=>,BRQS69Mb_ÉA�< :=<P_W:=KW:Ø_Ô6PA�M7XdZ1[ÛVLA�]`EU>CE�V��æÚÉE�?@:=>CDWV�Í�A�<WV VaQ�ßCE&E�]ÉQC698 47698a:=<9>�?�ACB;D9:=<9E&Fã8LA�V;D9E&8

Fa?�A�M=M`VaQ@?�A�ßSEYVaD\E�BR8a6`BR:bA�M�BRÈ9BRM=:=Ê�A�V;:^QS<9F�:=<�FaVaE�]9F � A�<`_"�UANFYM=:=ßCE&M=È@ANFY]`QCFaF;:=T9M=ECÏ�crÑLh\D9Q�Í%E�KCE&8Hh9Í�E�Í%E�8aE�Í�:^M=M=:=<9>�V;QQC]`E&8RA�VaEãQC698·4O6\8a:=<9>�?�ACB;D9:=<9E&F�A�V·KCE&8;È�M=Q�Í X Z1[ìBRQC<`BRE&<WVa8RA�Va:=QS<9F�VaD9E�<U?U6PB;D�MbA�8;>CE&8�VLAN]PE�FÃBRQS69Mb_�TPE�6\FaE�_�Ï ¨%���%�N�­«?,AN:=<¦VRA�:=<9F%A � h¹ü�����ßW:=M=QCTPANFaE BR:=8LBR69MbAN8Y>CE�<9QC?�ECÏ�[ÛXdZ1[iVRA�]`E�Q�Ñ�VaD\:^F�F;:=Ê&E�Í�QC6\MØ_�DPAHKCE!Fa]PASBRE Ñ5QS8dý�� �9h��� �Uú���T`A�FaE]PAN:^8�FaÈW?UT`QCM=F�ÏÖcrÑLh9A�F�TPEgÑ5QC8;EChWVaD9E�BRE�M^M=F�D9QSMb_�?@E&?UT`E&8aF·Q�Ñ#A � FaÈW?UTPQSMPA�M=]9D`A�T`E&VÃAN<P_UV;D9E&8;E�A�8;E��!T9:=VaF�]PE&8�TWÈWVaE V;D9:=F>C:=KSE&F�69FYA�< � ��ßW:=M=QCTWÈWVaEY?�E&?@QS8aÈ�]`E&8ãVLA�]`ECÏ�Rþ�� �C�9�R�R�

ù E�FaVa8;:bBRVa:=QC<�8aE�ASBRVa:=QS<9F%8;E�ÎS69:=8aEãKCA�8aÈW:=<9>�AN?@QS69<WVaF7Q�ÑfV;:^?�E%T`A�FaEH_UQC<UV;D9EY]`A�8aV;:bBR69MbA�8�E&<9Ê&ÈW?�EChCV;E&?@]`E&8RA�Va6\8aECh8aEHACBRV;:^QS<ÉT96WÕ�E&8�AN<P_�E�<9Ê&ÈW?@EUBRQC<`BRE&<WVa8RA�Va:=QS<É69FaE�_ÖÏU47QÙA�ÌP8;FaV�AN]9]98;QHøÔ:=?�A�Va:=QS<fhWVaD9EU?�QC8;E�QS<9E�F;]PE�<P_WF�h7V;D9EU?@QS8aEE&<9Ê�Ȧ?�E@QS<9E@B&A�<¶69FaE�AN<P_ VaD9E�ѽANFaV;E&8�V;D9E@8;E�ACBgVa:=QC<¶Í�:^M=M�]98aQ9BRE�E�_�Ï2I � ù E&FaV;8a:bBRVa:=QS<|E&<9Ê�Ȧ?�E&F�h7D\Q�Í%E&KSE&8�h·E&Fa]`E�BR:bANM^M=ÈBRMbA�F;F�c;cae E&<9Ê&ÈW?�E&F � M h�AN8aEU<9QSV�:=<9ERø9]PE�<9Fa:=KCESÏÆê\698aV;D9E&8�h7:=V�:=F�8;E�BRQS?@?@E�<P_WE�_àVaDPANV�FaQS?@E�E&<9Ê&ÈW?�E&F�h7<9QSVLANT9M=È �Ö��¯ c&h<9QSV%T`E 69FaE�_�V;Q � ����°L�N«=»N�g�R� XdZ1[�ÏW4�DPANV%:=FHhCV;D9E E&<9Ê&ÈW?@E�F�FaD9QS69Mb_W< � V�T`Ed6\FaE�_�A�V�BRQS<PBRE&<WVa8RA�V;:^QS<9FY?U6`BaDUD\:^>SD9E&8�VaDPAN<VaD\QCFaEU8;E�BRQS?@?@E�<P_WE�_�TWÈ�V;D9E�Fa69]9]\M^:=E&8HÏ KCE&< : ÑÃBRQSFaV�:=Fa<�� V�AN<�QCTC×REHBRV�VaD\:^F ]96\VaF�QS<9E�M=:=?@:=V�QC< QC698�ANT9:=M^:=V�È�VaQ�T969ÈѽANFaVaE�8�8aE�ASBRVa:=QC<�V;:^?�E&F�Í�:^V;D@>S8aE�ANVaE&8ãE&<9Ê&ÈW?@E�BRQS<PBRE&<WV;8LA�V;:=QC<fÏ7ÚÉE�A�F;Fa69?�EChSVaD9E&<�h9VaD`A�V�QC6\8�FaM=Q�Í%E�FaV�8aE�FaVa8;:bBRVa:=QC<\FdA�8;E?,AS_WE�A�V �a<9QS8a?,ANM ��8;E&FaV;8a:bBRVa:=QS<ÆE&<\Ê&ÈW?@E�BRQS<PBRE&<WV;8LA�V;:=QC<9F�F;Q@V;DPA�V�A@BgQC?@]\M^E�VaE�_W:=>CE&F;V :^F ACB;D9:=E&KSE�_�Í�:=V;D9:=<ÙAN<�D9QS698�Ïí�:=>WA�Va:=QS<9F�8a69<ÉA�V �����&Þæ?,AHÈ�TPE�BgQC?@]\M^E�VaE�_�:=<Æý ��?@:=<W69VaE�F�ï�� � þ$ô´Ï1[YFaF;69?@:=<9>UV;DPA�V�ANM^M�Q�Ñ�VaD\E�8;E�ACBRV;:=QC<9F�B&AN<�TPE]`E&8�Ñ5QS8a?�E�_UQS<@FaQSM=:Ø_�Fa69]\]PQS8aV�FaQ�VaD`A�VYBRM=E�AN<¦6\]@:=F%?�:=<9:=?,AHM�hHVaD9E�ý!8aE&F;Va8a:bBRV;:=QC<9FYAN<P_�ý�M=:=>¦ANVa:=QC<9F7]`E&8�ÑrQC8a?�E�_UV;QU?@Q�KSEÑ58;QC?�QS<9E caX VaQUV;D9E <9ERø9V�Í�:=M=M�VLA�ßSE QC<@V;D9E�QS8L_WE&8ãQ�Ñ � Ï �D\QC698;F�Ï����� ¨%�`�&°´»~:

ÚÉE�_WE&FRBR8a:=T`E�_�h�:=<�eWE�BRV;:=QC< �\Ï �\h9Þ�DPA�8;M=E&F Ç E&<9<9E�VaV � F KW:=Fa:=QC<�Q�Ñ%_W:=FaF;:^]`A�Va:=QS<9M=E&FaFYBRQS?@]96\VaE&8;F�Ï�I�<WÑrQC8aV;69<PANVaE&M=ÈWhQC6\8�?,ACB;D9:=<9E�FÃAN8aE <9QCV�8;E&KCE�8aFa:=T9M=ERëÜM=QC>S:bB&A�M=M=ÈUQC8YB;D9E&?�:bB&A�M=M=ȦÏÖ4�D9E Fa?,ANM=MJI14YÐ�F�Í%E ]98;QC]`QCF;E�VaQU:=?@]\M^E�?@E&<WV�_WQU<9QSVDPAHKSEY8aE�KCE&8;Fa:=T9M=E Va8LAN<9Fa:=V;:^QS<9FYA�<`_UD9E&<`BRE�M=QCF;EY:=<WÑ5QS8a?,ANVa:=QC<�ÏP[ãF�Ñ5QC8·VaD9E�B;D9E&?�:^F;Va8;ȦhS8aE&F;Va8;:ØBgVa:=QC<9F A�8;EYÑr8aE&EChWQS8YA�V�M=E�A�F;VVaD\E&Ȫ_ÔQ�<9QCV�BRQCF;V%69F·ERø9Va8LA$E&<9E&8;>CÈWÏ74�D9EYM=:=>¦ANVa:=QC<9FHhHD9Q�Í%E�KCE&8HhC8;E�ÎS69:=8aEYV;DPA�V·QC<9E�D9:=>SD�E&<\E&8a>SÈU]9D9QCF;]9DPANVaEYT`QC<`_�h�Ñr8aQC?VaD\E�DWÈÔ_Ô8aQCM=ÈWFa:=F�QNÑ·AN<�[�4Yõ¶?@QCM=E�Bg69M=EYVaQU[ Ð�õÜAN<P_�õ�õ���h9T`E�Fa]`E&<WVYE�KCE&8;È,V;:=?@EdA�<\:ØB;ß�:^FãFaE�ANM=E�_�:^<�V;D9E�]9D9QSFa]9D`A�VaETPASBaßWT`QC<9ESÏ�4�Í�QU[�4Yõ7FYV;D9E&<fh`A�8;E�8aE�ÎS69:=8;E�_�VaQY×gQC:=<@E&KSE&8aÈ�]PAN:=8�Q�ÑOF;Va:bB;ßWÈ,E�<P_WF�Ï�4�D98;E&E�M=:=>¦ANVa:=QC<9F�A�8;E ]PE&8´Ñ5QC8;?@E�_�V;Q?@Q�KSE�Ñ58aQS?�QC<\EdcaX VaQUV;D9E <9ERø9Vd_W6\8a:=<9>�Í�D9:bBaD�Í�E ?U69FaV�Fa]`E&<P_�ANTPQS69V � � � B&A�M �N?@QCM=EYX Z�[ VRA�]`E&F�Ï � �

eW:=<PBRESh7:^<É]\8a:=<PBR:=]9M=ECh7A�M=M�QNÑÃV;D9E@M=:=>¦ANVa:=QC<ÆAN<P_ 8aE�FaVa8;:bBRVa:=QC<¶8aE�ASBRVa:=QS<9F�Í�E@]`E&8´Ñ5QC8;? Í�QC6\MØ_àT`E@8aE�KCE&8;Fa:=T9M=E,ANVE�ÎS69:=M=:=T98a:=69? haÍ�DWÈ�_WQC<�� V�Í�E�VRA�ßCE�AS_WKCA�<WVLAN>CE7Q�Ñ9V;D9:=FfA�<P_ T\69:=MØ_ãA�<9EHA�8O_Ô:^F;Fa:=]PANVa:=QC<9M=E&F;FfBRQC?�]969V;E&8���ê\QC8�QC6\8fBRQC?�]969VaE�8VaQÉQS]PE�8LA�V;EÆBRQS8a8aEHBRVaM=ÈÀÍ%E�8;69<À:^VUA�F�Ñ�A�8�Ñ58;QC?�E�ÎS69:=M=:=T98a:=69?�ANFU]PQSFaFa:=T9M=E��æí�:=>¦ANFaE�Í�:^M=M�]`E&8�ÑrQC8a? VaD\E �;8aE&KSE&8aF;E �ÀQ�Ñ:=VaF�<9QC8;?,ANMOQS]PE�8LA�V;:=QC< AN<P_ <9:bB;ß|_WQC6\T9M=ERÒ½F;Va8RA�<P_WEH_ X Z1[�:=<ÉVaD9E�]98;E&FaE&<`BRE�Q�ÑY[ Ð�õ�ï� ���HôÃT96\V�:=V�_WQWE&F;< � Vª_ÔQÆF;QFa:=V;ERÒ½F;]PEHBR: ÌJBRM=ȦÏà[�V�E�ÎS69:=M=:=T98a:=69? M^:=>WA�FaEUÍ�QC6\MØ_ BR69V�VaD\E,X Z�[�VRA�]`E&F�Í�:^M=M=ÈSÒ½<\:^M=M=È,AN<P_ QC6\8�BRQC?�]969VRA�Va:=QS<ÆÍ�QC69Mb_àTPED9QS]PE&M=E&F;FaM=È|FRBR8LAN?UT9M=E�_�ÏÀê9QS8UFa:=?@:=MbA�8 8;E�A�F;QC<9F�Í%E�Í�:=FaDÀVaQ ßCE�E&]ÜVaD\E,8;E&FaV;8a:bBRV;:^QS<9FUÑr8aQC? 8a69<9<\:^<\>ÉTPACB;ßWÍÃAN8L_SëÜV;D9E8aE�FaVa8;:bBRVa:=QC<¶E&<9Ê&ÈW?�E&F�DPAHKSEU<9Q�Í�AHÈÆQNÑ �;ߦ<\Q�Í�:^<\>��PhJÑ5QC8�Egø\AN?@]9M=EChÖÍ�D9:bBaDÉF;ÈW?UTPQSM^F Í�E&8aE�MbA�FaV ERøPBR:=F;E�_ÝÑ58aQS?ðÍ�D9:bB;DVLAN]PE�F�Ï�c�<�A�]`QC]\69MbA�Va:=QS<UQ�ÑOVRA�]`E&FYA�VY_Ô:­Õ�E&8;E&<WV�FaVLAN>CE&F�QNÑ#BRQS?@]96\VLA�V;:=QC<�QC8�]`E&8�Ñ5QS8a?�:^<\>�_W: ÕJE�8aE&<WVYBRQS?@]969VRA�V;:^QS<9F�V;D9:=F?@EHA�<9F�VaDPANV�FaÈW?UT`QCM=F�Í�QC69Mb_�TPE 8RA�<P_WQS?@M=È�8aE&:=<PBRQS8a]`QC8RA�VaEH_�:=<@VaQUQS698YX Z�[ VRA�]`E&F�Ï

Ç E&<9<9E&V;V � FdBgQC?@]\69VaE&8�>CE�VaF�AHÍÃAHÈ�Í�:=VaD@QS]PE�8LA�V;:=<9>ªANV%EHÎC6\:^M=:=T98;:^6\?ÓTWÈU]`E&8�ÑrQC8a?�:=<9> :^V;F%V;8LAN<9Fa:=Va:=QS<9FYA�F�Fa:=<9>SM^EShFa:=V;ERÒ½F;]PEHBR: ÌJB�ANVaQS?@:bB�F;VaE&]9FHG�VaD\E�FaVRA�VaEShPF;ÈW?UTPQSMJAN<P_�D9E�AS_�]PQSFa:=Va:=QC<�B;DPAN<9>CE�AN8aE�ANM=M�]PE&8´Ñ5QC8;?@E�_�ANVYQC<`BRE�TWÈ,A�F;:^<\>CM=EE&<9Ê�Ȧ?�ECÏ7ÚÉEYF;]9M=:=V%QS698�Va8RA�<9F;:^V;:=QC<9F�69]�:=<¦V;Q�F;VaE&]\FYÍ�D9:bB;Dfh9:=<�8aE&KSE&8aF;ECh�A�8aE <9QSV�Fa:=VaEgÒ½F;]PE�Bg:­Ì�B�A�<P_�B&AN<�TPE ?@: ø9E�_UAN<P_?,ANVLB;D9E�_�VaQ�Ñ5QS8a?�V;8LAN<9Fa:=Va:=QS<,QSM=:^>SQC<W6PBRM=E&QSVa:b_WE&F·VaDPANV�Í%E&8;E�<9QSV�]PA�8;V�Q�ÑOQS698�QC8;:=>C:=<PA�M`47698a:=<9>�?,ASB;D9:=<9ECÏ

� ��� �v������. � .���.5) �G� ��),HB��$Y�������c�<�eWE�BRV;:=QC<"��Í�Ed_ÔE&?@QS<9FaV;8LA�V;E�_�VaDPANVYÐ�:=<9FaßWÈ � F � ø,ü�47698a:=<9>!?,ACB;D9:=<9E!3½AN<P_UD9E�<PBRE�ANM^M � ø,ü!4YÐ�FLj�BRQS69Mb_

T`Ed:=?�]9M=E&?UE&<WVaE�_!69F;:^<\>ªBRQS?@?�E&8LBR:bANM^M=È�AHKCA�:=MbA�T\M^È 8;E&FaV;8a:bBRVa:=QS<,E�<9Ê&ÈW?@E&FHÏ74�D9E ]98aQ9_W6`BRV�Q�ÑfV;D9E <¦6\?UTPE&8·Q�ÑOF;VLANVaE&FYAN<P_FaÈW?UT`QCM=FU3 ����:=<|V;D9:=FªB�A�FaEHj�:^F�FaQS?@E&V;:=?@E&F VLANßCE&<ÀA�FUA�M=QWQCF;E@?�E�A�F;698aEUQNÑdVaD\E,BRQS?@]9M=ERø9:=V�ÈÆQNÑdA�47698;:=<9>�?,ASB;D9:=<9ECÏ[Y]\]9M=Ȧ:=<9>!VaD9:=F�?@EHA�Fa6\8aEYV;QªX Z1[ì47698;:^<\>�?�ACB;D9:=<9E&F�Í�E�A�F;ß��7Ú+DPA�V�:=F�V;D9E MØAN8a>SE&FaV�FaVRA�VaEgÒ½F;Ȧ?UT`QCM`]98;QÔ_Ô6PBRVYV;DPA�V�QC6\8±�( gw�2�tm h<��-�j�y�h�gC�2�Vi�gkdxlN�9�xs{�9lNy�h�dqrk�9��noi�ges{�9lN��p2�2|Qh�dws{�9g��9g�h5�tlc�tmNs dxl�y�iN|�h-iN�{j �xsth<y��9gkdPgesQ�tz{z{h5rN���)��&0 � ( b,�9g/�xsth�iN��i?g�h<��-�j�y�h�g[m?lN�v�9d/��l?gkdxg� ��c£#nolcr�iN��iNy�lN�{�{d�dwsti?dC��ic� zQ�9m?h�gkd/¢N£-y�m lNnt� �����2��iN��stlN�{r �[�Psth��5p9i�gkg/bxb�� h<��-�j�y�h�g�/��� b�ic�tz � 8;<e��b#��l?gkd�¢c£ iN�tz�¢c£?£ dw�2y�h�gPi?gPy��t�xs/�Nr�h�ge�Ch���de�9�?h<p9j?���a ��gxge�{y��2�tm�ic}�lN�td��Q� ��� ��icp���y�lNpt�/� ��s{j�zQr5lNp9j&-�h�z*¨ ��� � {­e�

Page 26: q s q ->

?@Q9_WE�MPB&A�<�ACB;D9:=E&KSE ��4�D9E�A�<\FaÍ�E&8Ã_ÔE&]PE�<P_WFYQS<@A�<�<¦6\?UTPE&8·Q�Ñ�ѽASBRVaQS8aF�:^<`BRM=6P_W:=<9>�V;D9E Fa]`E�BR: ÌJBR:=V�È@A�<`_@BRQS?@]PANVa:=T9:=M=:^V�ÈQ�Ñ7E&<9Ê&ÈW?�E&FYA�<P_�VaD9E!<¦6\?UTPE&8�Q�Ñ7?@:=Fa?�AHVLB;D9E&F·Í%E 8aEHÎC6\:^8;E�:=<@:=<PBRQS8a8;E�BRVaM=È�]PA�:=8aEH_@Q�KSE&8aD`A�<9>SF�Ï7[YF;Fa69?�:=<9>PhWA�F�T`ERÑ5QS8aEChVaD`A�VUÍ�E�Í%QS69Mb_ÉM=:=ßCE�VaQÉD`AHKCE � TPA�F;E�?@:=F;?,A�VRB;D9E&F�TPE&V�Í�E&E&<+:^<`BRQC8;8aE�BRV;M=È ]`A�:=8aE�_ Q�KCE&8;DPA�<9>SF@A�<P_ÀANFaFa6\?@:=<9> VaDPANVÍ�E,?�AHÈÆ6\FaE�A�M=M�Q�Ñ VaD9E�BRMbANFaFUcacae¶8;E&FaV;8a:bBRVa:=QS<ÜE&<9Ê&ÈW?�E&FUßW<9Q�Í�<|:=<|V;D9E�M=:=VaE&8RA�V;698aE�Í�E,E�FaVa:=?�A�VaE�VaDPANVUQC698�?@Q9_WE�MB&AN<ÆF;:^?U6\MØANVaE 47698a:=<9>U?�ACB;D9:=<9E&FãÍ�:=VaDÆA�FaVRA�V;ERÒ½F;ÈW?UTPQSMf]98;QÔ_Ô6PBRV�QNÑÃA�T`QC69VV���\Ï�I�M=Va:=?,ANVaE&M=ÈUV;D9E�F;:=Ê&EUQ�Ñ%V;D9E�4O6\8a:=<9>?,ASB;D9:=<9E&F�V;DPA�V�B&A�<�TPEãT969:=M=V�Í�:=VaD�QC698�?@E&V;D9Q9_�Í�:=M^M`_WE&]`E&<P_�QC<�VaD9E _W:=FLBRQ�KSE&8aÈUQNÑf<9E&ÍæE&<9Ê&ÈW?@E�FÃAN<P_�QC698�A�T\:^M=:=V�È�V;QE&<9>S:=<9E&E&8�<9E&Ͷ8aE&F;Va8a:bBRV;:=QC<@E�<9Ê&ÈW?@E&F·Í�:^V;D�<\E&ÍÀ8aE�BRQS>C<9:=V;:^QS<ªAN<P_UBRM=E�AHKCAN>CE�Fa:=VaE&FHÏ7[ÀFaE&8;:^E�F%QNÑJ8;E�BRE&<WV�]PA�]`E&8aFã3Lï��7*�Àó�ôahï��7�� �Sôah�ï26%7 �`ô5j�_WE&?@QS<9FaV;8LANVaE VaDPANV �Ö��¯ c�B&A�<�T`E�?U69VLANVaE�_�VaQ�>C:=KCE <9Q�KSE&MfBRM=E�AHKCAN>CEYF;]PEHBR: ÌJBR:=Va:=E&FHÏ

4�D9:=F�E&<`BRQ9_W:=<9>ÆQNÑÃ47698;:=<9>�?,ASB;D9:=<9E&F�ACBRV;6PA�M=M=È�ÈW:=E&Mb_WF�A�?�Q9_WE&M�QNÑdBRQC?�]969VLANVa:=QC<àFaM=:=>CDWVaM=È�?�QC8aE�]`Q�Í%E&8´Ñ569MVaD`A�<@AãFa:=<9>SM^E�VLAN]PEã47698a:=<9>ã?,ACB;D9:=<9ESÏfXã698a:=<9> VaD\EdBRQS698aF;EYQ�ÑfA BRQC?�]969VRA�Va:=QS<�VaD9E�V;8LAN<9Fa:=Va:=QS<�VRA�T9M=E�?,AHÈ T`EYB;DPA�<9>SE�_�Ï4�D9:=FYBRQS69Mb_,ANM=M^Q�ÍæA�FaE&VãQ�Ñ�Fa?�A�M=MPV;8LAN<9Fa:=Va:=QS<,VRA�T9M=E&F�V;QUTPE�A�]9]9M=:=E�_�VaQ@AUX Z1[ VLA�]`E�F;E�ÎS69E&<WVa:bA�M=M=ÈWhWE�ACB;DÆASBRVa:=<9>@ANFYAFa6\T98aQS69Va:=<9E!Ñ5QC8 A�MØAN8a>SE&8dBRQS?@]96\VLA�V;:=QC<fÏ�[ _9_W:=Va:=QS<PA�M=M=ȦhWEHACB;DÉVa8RA�<9F;:^V;:=QC<�:=<�V;D9E�V;8LAN<9Fa:=Va:=QS<�VLANT9M=E�<9E&E�_ <\QCVYÍ�8;:=VaEUAFa:=<9>SM=EYFaÈW?UT`QCM�Ï�4�D9E �a8aE�Fa69M=V���8aE�>C:=QC<�Q�Ñ7E�ACB;D�Va8RA�<9F;:=Va:=QC<�QCM=:=>CQC<W6PBgM^E�QCVa:b_WE B&A�<�DPAHKSEdAN<,A�T\:^V;8LAN8aÈ@8;E&Fa6\M^V�F;Va8;:^<\>UVaDPANVD9QSMØ_ÔF�?,A�<WÈ�F;ÈW?UTPQSM^F´ëÜQC8�<9QS<9ECÏ74�D9:=FYANM^M=Q�Í�F�69F�VaQUAC_\_,BgE&M=M^F�V;QUVaD9E VRA�]`Ed: Ñ7Í%E <9E&EH_�?@QS8aEYF;]PACBgECh9QS8Y_WE&M=E&VaE�BRE&M=M=F: ÑOV;D9:=F�Fa]`E&E�_WF 69]�VaD\E$BgQC?@]\69VLANVa:=QC<fÏ

crÑYÍ�E@BaD\Q¦QSFaE�VaQ�8;69<ÉQC698!4O6\8a:=<9>�?�ACB;D9:=<9E&F :=<ÉFaQSM^6\Va:=QC< :=<9FaV;E�AC_ QNÑYQC<ÉFaQSM=:Ø_àFa6\]9]PQS8aV�3½eWEHBRVa:=QC<|ü\Ï�Cj Í�E?@:=>SD¦Vf_ÔE�BR:b_WEYV;Q VLA�ßSEÃAS_WKCA�<WVRA�>CE�Q�Ñ`VaD9E�]9MbANFa?@:b_ � F�<PA�V;698LANMÔBg:^8RBR69MbA�8·TPQS69<P_9AN8aÈ�BRQS<P_W:=Va:=QS<�V;Qd:=?�]9M=E&?@E&<WVfA _W: Õ�E&8aE&<WVFa:=?�]9M=Ed?�Q9_WE&MfQNÑ%BRQC?�]969VLANVa:=QC<�hPAU47[ � FaÈWF;VaE&? ÏY[Û47[ � FaÈWFaV;E&?Æh`M=:=ßCE�AU47698;:^<\>@?,ASB;D9:=<9E 69FaE&F�Aàú�_W:=?@E�<9Fa:=QC<`A�MVLAN]PE�T969VHh7:^<\FaVaEHAC_ÉQNÑÃ?�Q�KW:^<\>@TPASBaßÉA�< ÑrQC8aV;D|QS<|A�VLAN]PECh7:=V�BgQC<WVa:=<W69QC6\FaM=È�B;D9E�Í�F�69]¶QC<9EUE�<P_ÉQNÑYVaD9E�VLA�]`ECh�AN<P_A�]\]PE&<`_WF FaVa8;:=<9>CF�QS<�VaD\E�QSVaD9E&8HÏ�crÑ%Í�E �LBR:=8LBg69MbA�8a:=Ê&E �@VaD\:^F ?�QÔ_ÔE&MfQNÑÃBRQC?�]969VRA�Va:=QS<ÙAN<P_�BRQS<9<9E�BgV�TPQSVaD E&<P_WF QNÑ%VaD9EVLAN]PE!Í�:^V;DÆA�8aEHAC_ �NÍ�8a:=VaE�D\E�AC_�T`E&V�Í�E&E&< VaD9E�?qÍ%E�>SE&VdA�?�Q9_WE&M�VaD`A�VYM=QWQCßWF�KSE&8aÈ�?U6PB;D�M=:^ßSE QC698YX Z�[ ?@Q9_WE&M�hWT96\V:=V%?�Q�KCE&F·:^<UQS<9M=ÈUQC<9E _W:=8aE�BgVa:=QC<fÏ7[æ47[ �æFaÈWFaV;E&? <9QC8;?,A�M=M=È�8;E�AC_WFYA!FaÈW?UT`QCM�h�Í�8;:^V;E&FYA F;Va8a:=<9>UV;DPA�V�:=FÃA$Ñ569<`BRVa:=QC<�Q�ÑVaD`A�V�FaÈW?UTPQSMPA�<`_UVaD\E&<�E&8LANFaE&F�F;QC?@EYBgQC<9F;VLA�<WV�<W69?UT`E&8�QNÑfFaÈW?UTPQSM=F�h � ÏSÚÉEYB&AN<,E�<PBRQ9_WE VaD9:=F�Í�:=VaD@QS698�XdZ1[Ü?@Q9_WE�MTWÈÆ6\Fa:=<9> ��� �@F;VLA�V;E&F�Ï�crÑ�VaD\EUD9E�AC_ F;VLANVaE�� :^F!QC<9EUQNÑÃV;D9E�ÌP8aF;V � FaVLANVaE&F�Q�ÑYV;D9EU?,ASB;D9:=<9ECh�V;D9E&<ÉVaD\EUVa8LAN<9Fa:=V;:^QS<QCM=:=>CQS<W6PBRM=E&QCV;:b_WEY:=<9F;Va8a6`BRVaF�V;D9E�D9EHAC_�V;Q@Í�8a:=V;E�<9Q@F;ÈW?UTPQSM½hWB;DPA�<\>CE�V;Q@FaVRA�V;E � � �UA�<P_�?�Q�KCEYV;Q@V;D9E�8a:=>SD¦VHÏ�crÑ�VaD9ED9E�AS_�:=FY:=<�FaVRA�VaE ��� ��� ��:=V�Í�8;:^V;E&FdA�8aE&F;69M=VYF;Va8a:=<9>�Fa]`E�BR: ÌJB�V;QUVaD9EUBR698;8aE&<WV FaÈW?UT`QCM�h9B;DPA�<9>SE&FYV;D9E�F;VLA�V;E ��V;Q�úA�<`_@?�Q�KCE&F�V;QUVaD9E!8a:=>CDWV�Ï·47E&8a?�:^<`A�Va:=QS<@:=<�A�4O[ � FaÈWFaV;E&? B�A�<�Ñ569<PBgVa:=QC<�×g69FaVYANFY:=VY_WQWE&FY:=<�47698a:=<9>U?�ACB;D9:=<9EãÍ�:^V;DVaD\Ed:=<PBgQC8a]`QC8RA�V;:^QS<�Q�Ñ#A�F;]PEHBR:bA�M ������UFaE�ÎS69E�<PBRE�:^<WV;Q�V;D9E�VLAN]PESÏ

� ��� ��@����C&A��!P)/���?��@ $Y�����-!#(���+ @�!#��$Y&�(�)/+-)/.���0 KSE&<ÜVaD\QC69>SD QS698@?�Q9_WE&M�B&A�<Ü]`E&8´Ñ5QC8;? FaM=:=>CDWVaM=ÈÉ?@QS8aE�BRQC?�]9M=ERø|Va8RA�<9F;:^V;:=QC<9FUV;DPA�<ìA �;<9QC8;?,ANM �à4O6\8a:=<9>

?,ASB;D9:=<9E%:=V%_ÔQ¦E�Fa< � V�FaE&E&? M=:=ßCE�QC698�?@Q9_WE&M`B&A�<�E&KCE&8�T`EY?U6PB;D!ѽA�F;VaE&8�V;DPA�<UF;:^<\>CM=E�VLAN]PEã4O6\8a:=<9>�?�ACB;D9:=<9E&F´ë V;D9E�D9E�AS_FaV;:=M^M�?�Q�KCE&F�QS<9E�BRE&M=MOANVdA�V;:^?�ECÏ74�D9E�ÎS69E�FaVa:=QS<�8aE&?�A�:=<9FQ��Þ�A�<�Fa?�A�M=MP47698;:=<9>�?�ACB;D9:=<9E&FHhPBRQS?@]96\VaEdAN<WȦV;D9:=<9>U69F;ERÑ569M:=<�8aE�ANFaQC<`A�T9M=E�V;:^?�E �ÉI�<ÔÑ5QC8;Va69<PANVaE&M=ÈWh9V;D9E�Fa?�A�M=M=E&FaVYI1<9:=KCE&8;FLANMf47698a:=<9>U?�ACB;D9:=<9E&F�ßW<9Q�Í�<�AN8aE ����°?: FaM=Q�Í�Ï�Ð�:=<9FaßWÈ � F?,ASB;D9:=<9EYVRA�ßCE�FdA�< A�?@QS69<WV%QNÑ�Va:=?@EãERø9]PQS<9E&<WVa:bA�M�QC<�V;D9E�F;:^Ê�E�Q�Ñ�VaD\E�VRA�]`E�Q�Ñ�VaD\E�?,ASBaD\:^<\Ed:=V�:=F�Fa:=?U69MbANVa:=<9>�V;Q@>CE�VÑ58;QC?iQS<9E�caX+Q�Ñ�VaDPANV�?,ASBaD\:^<\E%V;Q�A�<9QSVaD9E�8�Ï7eWV��ANMP[ A�<P_WE�8LACA�ï ñ WôJB&ANMbBR69MbA�V;E&F�VaD`A�V�D9:=F��´Ñ½A�:=8;M^È F;?,A�M=M ��ú&�1ø ��I14YÐ��?I8aEHÎC6\:^8;E&F����\h � ���!FaV;E&]9F VaQ�AC_WKCAN<PBRE�V;D9E�Fa:=?U69MbANVa:=QC<UQNÑ·A �!ø �U47698a:=<9>�TWÈ�QC<9E�caX Í�D9E�<�VaD9E!Fa:=?U69MbA�V;E�_U?�ACB;D9:=<9E�� FVLAN]PE�D\QCMb_WF�QS<9M=ÈE�ãFaÈW?UTPQSM=F �fÐ�ASB;D9:=<9E&F�V;DPA�V�6\FaEY6\<PA�8;È�8;E&]98aE�FaE&<WVLANVa:=QC<\F%QNÑJQSVaD9E&8�?,ASB;D9:=<9E&F�hN:^V7F;E&E&?@FHh¦AN8aEY_WQWQS?@E�_VaQUT`E FaM=Q�Í�Ï

ÚÜD9:=M=EUI�<9:=KCE�8aFLANM%?�ACB;D9:=<9E&F ?�:^>SDWVY<9QSV�TPE�]98LASBRVa:bB&ANM%47698;:=<9>�?,ACB;D9:=<9E�FdV;Q�:=?@]9M=E&?�E&<WV�Í�:=VaD|X Z�[�h�:=V�:=F]`QCFaF;:=T9M=E%V;DPA�V�Fa?,ANM=M^E�8�Fa]`E�BR:bA�M9]\698a]`QCF;E%?�ACB;D9:=<9E&F�Í�D9:bBaD!VLA�ßSE%QS<9M=ÈYKSE&8aÈ�F;?,ANM^M�]`QCM=ÈW<9QS?@:bA�MHVa:=?@E7QS<�V;D9E%F;:=Ê&E%QNÑPVaD\E&:=8:=<9]969V�VLAN]PE�F�35D\QC]`ERÑ569M=M=È�M=:=<9E�AN8%V;:=?@E��¹j ?�:^>SDWV�]PE�8�Ñ5QS8a?ËA!69FaEgÑ569MOBgQC?@]\69VLANVa:=QC<fÏÖ4�D9E�_WQC?�:^<`A�<WV�XdZ1[iBRQC?�]969VRA�Va:=QS<]PAN8LAC_Ô:^>S?)3½A�Ñ5VaE&8![d_WM=E&?�A�<ÆAN<P_ Ç QS<9E&D �g�$�N�­� j¶:=F�VaQ�69F;E@BRM=E&KCE�8�F;E&M=E�BRVa:=QS<ÉVaE�B;D9<9:bÎS69E&F�VaQ�ÌP<`_ÉA�<9F;Í%E&8;FªA�F;E�A�8RBaDFa]`ACBRE Q�Ñ�A�M=M`]PQSFaFa:=T9M=E ]98;QCT9M=E&?�F�Ï Ç È�8aE�_W6`BR:=<9>UVaD9E F;:^Ê�EdQNÑfVaD9E :=<9]96\V�VaQ�VaD9E&F;E�FaE�M^EHBRVa:=QC<�TPANFaE�_�BRQS?@]96\VaE&8;F%Í�E ?,AHÈT`E@A�T9M=E�VaQ�Fa]`E&E�_ V;D9E&?ð6\]fÏUõfE�8aDPAN]9F�Fa?�A�M=Mf47698;:=<9>@?�ACB;D9:=<9E&F�BRQS69Mb_�T`E�6\FaE�_ÉANFd]\8aE&]98;Q9BRE&FaF;QC8;FUÑ5QS8YQCV;D9E&8�X Z1[BRQS?@]969V;E&8aFHÏ@4�D\EU8aE�ANMÃB;DPANM^M=E&<\>CEUD9E&8;E@:=F VaQ�Ì`<P_ 69FaEgÑ569M�:^<\]969V MbA�<9>S6PA�>SE&F Ñ5QS8dF;E&M=E�BRV;:^QS<|TPANFaE�_ÉBgQC?@]\69VaE&8;F�Í�D9:bB;DFa?�A�M=M`4O6\8a:=<9>�?,ACB;D9:=<9E�FÃB&AN<�>CE&<9E�8LA�V;E�:=<,A!Ñ5E�ÍìF;VaE&]9FãVaDPANV�FaVRA�<P_9AN8L_�FaÈW<WVaD\E&Va:bB V;E�B;D9<9:bÎS69E&FdB�A�<9<9QSV�Ï

ÅÉç|å Å ��éæÁ�ä9ç|åc�<�VaD9:=Fã]PA�]`E&8YÍ�E 69FaEH_�VaD9E!QC]`E&8LANVa:=QC<�Í�E�B&A�M=M �Lõ78;QC>C8;E&FaF �,AN<P_�VaD9E�BgQC<PBRE�]9V Q�Ñ#Bg69VaV;:^<\>UÑ58RA�?@E�F%]98;Q�KW:Ø_ÔE�_

TWÈ�BRMbA�F;F�cacae!8aE�FaVa8;:bBRVa:=QC<�E&<P_WQS<W6PBRM=E�A�F;E&F�VaQ ]98aQS]PQSFaE�QS<9E�ÍÃAHÈ QNÑJE&<`BRQ9_W:=<9>�A 47698a:=<9>ã?,ACB;D9:=<9E·Í�:^V;DªX Z1[ B;D9E�?@:=FaV;8aÈWÏ�5± ��iN�tz{h<r�i?i�f gCy�i?�xs{�2�thP�9g�dxlQl }{�9m dxl%}�h-�2y��{p9h5y�h<�~dxh�z�uP�9dwsAlN�{r#h5�t��lQzQ�2�tm-�tge�2�tm�lN�{p9j���lNy�y�h<r��<�9iNp2p2j�iN� ic�2p9iN}{p9h#h5��-�j?y�h�g��

�t�

Page 27: q s q ->

ÚÉE�A�F;Fa:=>C<9EH_@8;E�A�M7X Z�[ FaEHÎC6\E&<PBRE&F V;QUQC698�FRBaD\E&?,ANVa:bB�V;DPA�VYBRQS69Mb_�TPE�6\FaE�_�Í�:=V;D,BRQS?@?@E�8LBR:bA�M=M=È�AHKCAN:^MbANT9M=E�E&<9Ê&ÈW?@E�FVaQU:=?�]9M=E&?@E&<WV%A�47698;:=<9>�?�ACB;D9:=<9Eã:^<�MbA�T�Ï%ê�:=<PA�M=M=ȦhSÍ�Ed8;E�BRQS>C<9:=Ê&E�_àVaD`A�V�VaD\E�47698a:=<9>U?�ACB;D9:=<9EY?�Q9_WE&M�hCÍ�D\:^M=E 69F;ERÑ569MÑ5QS8�]98;Q�KW:^<\>�VaD9E�QC8aE�Va:bB&A�Mã8aE&F;69M=VaFHh%?�AHÈ�T`E@VaQWQ FaM=Q�Í�V;Q�_WQÉA�<WÈ ]98LASBRVa:bB&ANMYBRQC?�]969VRA�Va:=QS<fÏ ÚÉE@_WQÆD\QC]`E,V;DPA�V�QC6\8_WE&?�QC<9F;Va8RA�Va:=QS<UVaDPANV�QC<9E Fa6\T9FaE&VãQ�ÑOX Z�[iB;D9E�?@:=FaV;8aÈ@B&AN<@Ì`E&Mb_@A�I�<9:=KCE�8aFLANMf47698;:^<\>�?,ASBaD\:^<\EYÍ�:=M=MP?�QCVa:=KCANVaE�QCVaD\E&8aFVaQãFaV;6P_WÈ�VaD9E�B;D9E&?@:=F;Va8aÈ QNÑPT9:=QCM=QC>SÈdAN<P_�BRQS?@E�69]�Í�:=VaD�A1FaE&8;:=E&F�Q�Ñ`QC]`E&8LANVa:=QC<9F�Ñ58;QC? Í�D9:bB;D�QS<9EÃB�A�<�T969:=Mb_dA �`°L�C²g��«5²R���69<9:=KSE&8aFRA�Mf?�QCM=E�BR6\MØAN8%BRQS?@]969V;E&8�Ͼ¶Å��æå ç�� �T��è �"���,åæÂÝÁ

c�Í�QC69Mb_ M=:=ßCE�VaQ VaDPAN<9ß|Ð�A�øÝAN<P_ � 6P_W:=VaD ù QCVaD\E&?U69<P_àÑ5QS8�VaD\E@>CE�<9E&8aQS69FU>C8RA�<WV�VaDPANV�?,AS_WEU?UÈ�FaV;6P_W:=E&FA�V·VaD9EYÞ�ANM^: Ñ5QS8a<9:bA1c�<9FaV;:^V;69VaE�QNÑJ47E�B;D9<\QCM=QC>SÈ�]PQSFaF;:^T\M^ESÏ��ÃA�F;E&8�[YT\6WÒ´ÐÙQCFaVRAHѽA!3�_WE&]9V�Q�Ñ�E&M=E�BRV;8a:bB&A�M�E�<9>C:=<9E&E�8a:=<9>�Þ�ANM^: Ñ5QS8�Ò<9:bA�Q�Ñ�47E�B;D9<9QSM=QC>CÈ9j�]98;Q�KW:Ø_ÔE�_�>C8aEHA�VYE�<¦V;DW69Fa:bA�F;?ÆhWE&<`BRQC698RA�>SE&?@E&<WVHhJAN<P_�:=<9]969V1Ñ5QC8�Í�DPANV�ÍÃANFdAN<,6\<¦6\Fa6PANMf]98;Q�×RE�BRVHÏ 8;:^ßUÚ+:^<ÔÑ58aE&E�3�Þ�ZYe@Þ�ANM=VaE�B;DPj�DPANF%ßSE&]9V�?�E�Í%QS8aßW:=<9>ªAN<P_UÍ�:=V;D9QC69V�D9:=?ÆhNc�<9E&KSE&8YÍ�QC69Mb_�DPAHKSEdANVaVaE�<P_WE�_�XãcaÐ�[YÞ�eÖÏc�Í%QS69Mb_UM=:=ßCEYV;QUVaDPAN<9ß � A�: � :^<\<Æ3�_WE&]9V�QNÑ Ç :=QCM=QC>SÈ@Þ�A�M=: Ñ5QC8;<9:bA c�<9FaV;:=Va69V;EdQNÑ�4OEHBaD\<9QCM=QC>SÈ9j7Ñ5QS8%M=E&V;Va:=<9>�?@Eã69FaE�X Z1[eWV;8a:b_WE&8�E�A�8;M=È�QS<fG �$8aE&>�ê\6�3½_ÔE&]9V�QNÑOBaD\E&?@:=FaV;8aÈUÐ�A�F;FLASBaDW69F;E&VaV;F�c�<9FaV;:=Va69V;EYQ�Ñ�47E�B;D9<9QSM^QS>CÈ9j7A�<P_ ù A�<P_ÔȪíÖE&E�3�_WE&]9V�Q�ÑÞ�D9E&?�:=FaVa8;È@I�<9:=KSE&8aF;:^V�È�Q�Ñ%î�QS69FaV;QC<Pj·ÑrQC8�E&<PBgQC698RA�>C:=<9>�?UÈU:=<WVaE&8;E&FaVã:^<�B;D9E&?@:=F;Va8aÈ�G`e9A�? ù Q�Í%E�:^F�A�<`_,íÖE&<�[d_WM=E&?�A�<Ñ5QS8OV;D9E&:=8�F;Va:=?U69MbA�V;:^<\>Y_W:=FLBR69F;Fa:=QC<�G¦ZãAC_W8;:ØAN<ªeÔE&E&?,AN<�ÑrQC8�_W:=FLBR6\FaFa:=QS<UQC<�E&8a8;QC8�BRQC8;8aE�BRV;:=QC<fG9AN<P_�[ _W:=Va:PXãDPAN>¦ANV�h Ç AN8a69<Þ�DPAN<P_W8LA\h9A�<P_�[ã?@:=VLANT9D@eWDPAND@ÑrQC8�:^<WV;8aQ9_W6PBR:=<9>U?�EYV;Q@Þ�e�Ï

ê�:=<PA�M=M=ȦhHc7Í�QC69Mb_�M=:=ßCE�VaQU_WE�_W:bB&ANVaEYV;D9:=F�]PAN]PE&8�VaQ!VaD9EãMØANVaE � Ï í·Ï [�ÏSKCA�<U_WEdeW<\E&]9FLB;D9E�69V�hÖ3½XãE&]9V�Q�ÑOÞ�QS?@]969V;E&8e9BR:=E&<`BRE@Þ�A�M=: Ñ5QC8;<9:bA�c�<\FaVa:=V;69VaE�Q�Ñ�47E�B;D9<9QSM^QS>CÈ9j�ÑrQC8Y:=<WVa8;Q9_W6PBR:=<9>�?@E VaQ�VaD9E�:b_WE�AUQNÑÃA@X Z1[i47698a:=<9>U?�ACB;D9:=<9EUï � WôaÏî�E Í�QC69Mb_�DPAHKCE T`E&E&<�ERøPBR:=V;E�_�A�<`_@]\M^EHA�FaEH_@TWÈ�VaD9E�_WE&KSE&M=QC]9?�E&<WV%QNÑ%XdZ1[iBRQC?�]969VRA�Va:=QS<fÏ�f��°�²R��©ã�P�=�R�a�!�&«b©��¦�=�H��«5���Ô�!�<4��r�Ô�!��²g�Ô��©ª���½«r² �� � �`�¦°�«b�W»U©ª�S²R�W«b�P� �`°L�g���&�W�a�R�U«b�à�r�¦«=���9�R�9�&°R�Y���L�`�­«5²�«=���������9�&�P²R�g�4��N°��5�9�T���%¥a�à�½°R���W�&«=��«5�N�|���­«Ø»N�N�9�9²&�=�L���½«r�C�g�L����°@�Ù�&«b©��W�=�H��«5���|�<4U�r�Ô�T����¥a�Æ©U�C²g�¦«b�`��� � U °R�R�Y��«b©ª�g�R�´�´�|�S�&«b�W»��r�Ô�g������ «=»C���9�9²��^�R�H��«5�C�g�R�%�`�^�R�H���@ö�°L�N®7�����S�5�=�P¬¹¸S¸P®�®·®��b�S»N²g�&�5²R���³�´�R²g�¦�5�R���H¸�¼ �P®#¯�°�¸����g�r�½�=�S�½©�����°U©U�H¯C����°R�����9�R�R��ö?:���©ª�N«b�7�a��P®#¯�°�±Y�N�­�W©��\«b�5²R���³�´�R²g�¦�5�R���W�

ð 'C �!�,�Y �

ï¹ñ � [ A�<P_WE�8LACA\h¦eÖÏ^h � E�8aKCE�M^M5�7[ I�<9:=KSE&8aFRA�M`4O6\8a:=<9>�Ð�ASB;D9:=<9ECÏ �%��©ã�P�S�´��°���²&«5���P²R���Ö�g»�«r²R���Ö�R²g�½�W°L� � �H�a�R� «b��%�N©Y�`�C�a��°Y��²&«5���P²R� 3Lú�ûSûCýSjYúgá � Ï

ï¹ñ [ãT96WÒaÐ�QCF;VLAHÑ�A9h��ªÏq�%� ���´�g����� � �?4��N°&©U�H��«5���Æ�N�P���%�N©Y�`�^����«Ø��: 3LúHûCû��Sj�F;E�B�Ï��9Ï�9Ïï¹ñ@ò·ó� [ _WM=E&?,AN<fh�í�Ïq�|Ð�QSM^EHBR69MbA�8�BRQC?�]969VLANVa:=QC<ÀQNÑ�FaQSM^6\Va:=QC<9F�VaQÀBRQC?UT9:=<PANVaQS8a:bA�M�]98;QCT9M=E&?�F�Ï �J²&«r�&�P²R� �[�t�

3Rú�ûCû � jãú+���9úRá�ú+��� � Ïï¹ñ@ò��� [ _WM=E&?,AN<fh¦í·Ï¹ÐÉÏq�Oâã<�Þ�QC<9F;Va8;6PBRVa:=<9>@AUÐÙQCM=E�BR69MbAN8YÞ�QC?@]\69VaE&8HϦXã8RAHÑ5VHh � A�<W6PAN8aÈ �9h�ú�ûSû \Ïï¹þ�ÿ���ó� Ç E&<9<9E�VaV�h�Þ Ï î!Ïq��í�QC>S:bB&A�M ù E&KCE&8;Fa:=T9:=M=:=V�È@Q�Ñ�Þ�QC?�]969VLANVa:=QC<�Ï � �����W�N�¦°��P���7�54 � �R���R��°R²R�����P� �����&�=�R�\¥

©U�&�Ô� ú�ü�3LúHûCüCýSj �� �á Cý��9Ïï¹þ�ÿ����� Ç E&<9<9E�VaV�h�Þ Ï¹î�Ïq� 4�D9EÆ4�D\E&8a?�QÔ_ÔȦ<`A�?@:bBRFUQNÑ�Þ�QS?@]96\VLA�V;:=QC<WëìA ù E&KW:=E&Í�Ï�� �W�´��°&�P���½«r���P�N���W�N�¦°��P�����<4

���9�L�N°L�g�½«r²L�N�`����:H�&«5²g� �\ú�3Rú�û����Cj�û�� Há9û � �\Ïï¹þA3 Ç 698L_ÔQC<fh9ÐÉÏ �UÏ=hWí�E&E�F�h � Ϲî�Ïq�7XãQC69T9M=ERÒ�FaV;8LAN<P_@BRM=E�AHKCAN>CE A�VYA!V�Í%QNÒ½TPANFaE�_WE&M=E&V;:=QC<@?�:=Fa?,ANVLB;D�:^<�A�X Z1[

D9E�VaE&8;QÔ_Ô69]9M=ERø�TWÈ@<W6PBRM=E�ANFaE�e�úCÏ �ër�H��²&«r�&�P²R� � �´�Ô�N°R�5� U3Rú�û�� Cj����SüHá/�Cý��\Ïï¹þ���� Ç QC<9E�Dfh9X�Ï^hSXY6\<¦Í�QC8;VaDfhWÞ Ï=h¦íÖ:=]9VaQS<fh ù Ï=hCeW>¦ANM=M½h � Ïq�Oâã<�Þ�QC?@]\69VLANVa:=QC<PANM9õfQ�Í�E&8�QNÑOX Z�[�ÏS47Q�A�]\]PE�AN8�Ïï ���� Þ�QSVaVaQS<fh ù Ï �UϹî�Ïq��XãE&VaE�BgVa:=QC<�Q�Ñ�Fa:=<9>CM=E�TPANFaE BaD`A�<9>SE&F%:=<U<W6PBRM=E&:bBãACBR:b_WFHÏ93 ù E&KW:=E&ÍYj ��«5�H²R�9�&©�«5²R�����W���W°R¥

�P�N� �t�SýU3Rú�û��SûCjãúRá�ú+�9Ïï � �� ���=���W�a�R²R� �%�H�a���^�g» Ï9Þ�M^QS<WVaE�B;Dfh9õ7A�M=Q�[YM=VaQ`h9Þ�[�ú�ûSûCý��\ú�ûSû � Ïï � �� Þ�8;QCVaD\E&8aFHh�X�ϹÐÉÏ=hfXã8RA�ß�h � Ï=h � A�D9<fh � ϹX�Ï=hfíÖE&KCE�<9ECh�e�ϹX�Ïq�dX Z�[ Ç E&<`_W:=<9>Ph7ê�M^EgøÔ:=T9:=M=:=V�Ȧh�AN<P_Éî�E&M=:bB&ANM

ù E&]PEHA�V�TWÈ,Þ�È9BRM=:=Ê�A�V;:=QC<��ã:=<9E&V;:bBRF�Ï �à�g�r�Ô�H�H��«b��¨%� � :�©U���=�R»{: �9ú �U3Rú�ûSû��Cj�ýHá9ý9úSÏ

�Cü

Page 28: q s q ->

ï ��� ê`A�DWÈWh Ï=hPX AHKW:^FHh �UÏ ù Ï^hWXã:bÐ�:bBaD\E&M=ECh�í�Ï � Ï=h � D9QSFaDfh�e�Ϲe�Ïq��XãE&F;:^>S<ÆA�<`_�FaÈW<WVaD9E�Fa:=FYQNÑ%]PQSM=ȦACBg8aÈWMbA�?@:b_WEgÒTPANFaE�_àQCM=:=>CQS<W6PBRM=E&QCV;:b_WE Fa69]9]`QC8;VaF ÑrQC8Y6\FaEU:=<�<W6PBRM=E&:bB�ACBR:b_�_W:bAN>C<9QSFaVa:bBRFHÏ-� �9²&�=�&«r²�� ²&«5��� � �g���L�N°L²g� �\ú3Rú�ûCûSýCjãú �\ú�ûHá�ú ���t�9Ï

ï � î1QC]�BR8aQNÑ5V�h � Ï Ï=hCI�M=M=?,AN<fh � ϹX�Ïq�&� �W��°L�H���9²g�½«r�����a��� �S�´�N©ª���´�U���9�R��°?:H���f���W»��9�H»C�R�R�%���`�U�%�N©Y�`�C�a�H��«5�N�9�[ _9_W:=FaQS<WÒ½ÚÉE�FaM=E&È@õ769T�ÏPÞ�QPÏ`3Rú�ûSüCûCj·FaEHB�Ï�ü9Ï2�9Ï

ï � î�×RE&M=?UÑ5E�M^VHh9[�Ï^hÖÚÉE&:=<¦T`E&8;>CE&8Hh ϹX�Ï=h ù QCF;F�h � Ïq� Þ�D9E&?@:bB&ANM7:^?�]9M=E&?UE&<WVLANVa:=QC<�Q�Ñ�<9E&698RA�M�<\E&V�Í%QS8aßWF�AN<P_47698;:^<\>ªÐ�ASB;D9:=<9E&F�Ï �%°L�H²�� � �H���­��� ²L�S���7��²&«b� ���U3Rú�ûCû\ú�jãú+�Sû��Cý�áJú&�Cû��Sü9Ï

ï26�7 � íÖ:^<�h�í·Ï=h�Þ�DPAN<P_W8LANFaE&>WA�8RA�<fhCe �&[YM=V;E&8LANVa:=QC<�QNÑ9VaD9E%BgM^EHAHKCA�>CE�_W:=FaVLAN<PBRE�QNÑ �f�H¯ ��8;E&FaV;8a:bBRV;:^QS<�E�<P_WQC<W6PBgM^EHA�FaETWÈU:=<9FaE�8aVa:=QS<,?U6\VLA�>SE&<9E&F;:=F�Ï �%°R��²�� � ���½� ���d²R�C�N���J²&«º� û �U3Rú�ûSûCýCj �Süt� Há �Süt���9Ï

ï26�7 ��ò� íÖ:^<`_W>C8;E&<fh ��Ï^h�Z1QC8L_\A�D9M�h�ÐÉÏq��I�<9:=KCE�8aFLANM%Þ�QC?�]969VRA�Va:=QS<@:=<ÆeW:=?@]\M^E âã<9ERÒaXY:=?�E&<9Fa:=QS<PA�M7Þ�E&M=M^6\MØAN8�[Y6WÒV;QC?,ANVLA\Ï �%��©ã�P�=������:H�R�´��©!� � 3LúHûCû �Cj �CûCû�Ò´ý\ú �\Ï

ï� � � A�D\<fh � ϹX�Ï=hCÞ�8;QCV;D9E&8aFHhPX�ϹÐÉÏq�fõ78;QCVaE�:^<ÔÒ½:=<P_W6`BRE�_UT`E&<P_Ô:^<\>�A�<P_UX Z1[ìBRÈ9BRM=:=Ê�A�V;:^QS<fÏ �%°L�H²&� � ���½� �9�d²R�C�N��J²�«b� �Cû�3LúHûCû��Cj��Cý � ýHÒ��Cý � ü9Ï

ï��7��Àó� �ã:=?Æh �YÒ��UÏ=h9Þ�DPA�<`_W8LANFaE&>WA�8LAN<fh�e�Ïq�%Þ�D9:=?�E&8a:bB�8;E&FaV;8a:bBRV;:^QS<�E&<P_ÔQC<W6PBRM=E�ANFaECÏ ��°L�H²&� � ���½� �f� ²L�S���7��²&«b� û\ú3Rú�ûCû � j ���SýHá ���Cü\Ï

ï��7�� �� �ã:=?Æh �YÒ��UÏ=h9í�:=<fh9í·Ï^h9Þ�D`A�<P_W8RA�F;E&>¦AN8LA�<�hPe�Ïq��c�<\FaE&8;Va:=QC<�A�<`_,XãE&M=E&V;:=QC<�Ð�69VRA�<WVaFãQ�Ñ �f�H¯ � ù E&FaV;8a:bBRV;:^QS< <`_WQC<W6PBRM=E�ANFaECÏ �W���W°&�P�N�O�54¡�ë5�N�^�g»�«r²L�N�7�7�Ô��©�«Ø�L��°?: ��3LúHûCû � j%ý\ú�ûSü��Há9ý9úHû����\Ï

ï� ���� �ãQC8;<WTPE&8;>Ph [�Ï=h Ç ANßCE&8Hh94�Ï [�Ïq�$B� � � �´�P� «5²R�H��«5���Ô���S�P��¨���«=��«5���\� ÚiϹî�ÏWê98;E&E&?,AN<@A�<P_UÞ�QS?@]PAN<WȦh�Z�E�Í�%QS8aß�3Rú�ûCûSýCj�Ï

ï� 7 Ð�:=<9F;ßWȦh`ÐÉϹí�Ïq�%eW:=Ê&E�A�<P_�eÔVa8a6`BRVa698;EUQ�Ñ�69<9:=KSE&8aFRA�M747698a:=<9>U?�ACB;D9:=<9E&F�69F;:=<9>@VRA�>UFaÈWF;VaE&?�F�Ï=h �%°L�H²&�·���r���:�©ã�P�·«b�@���S�P� � �Æ���5�W� [ã?@E&8;:bB&A�<�Ð�ANVaD9E&?�A�V;:ØBgMJeWQ9BR:=E&V�ÈWh9õ78;Q�K¦:b_WE�<PBRECh ù c&h`3LúHût���Cj ���Cû�á �Sý��9Ï

ï�� /7 ZãA�:=VaQ`hf4�Ï=h7�ã69FLAN<9QPh7��Ï=h7�ãQCTPAHÈWA�F;D9:�hfc&Ïq�UeWE&M ÌPF;D|T`E&DPAHKW:=QC698�QNÑY8aE&F;Va8;:ØBgVa:=QC<WÒ�?@Q9_W: ÌJB�A�Va:=QS<ÆF;ȦF;VaE&?�F�Ï�J²�«5���P²R� �t�SüU3Rú�ûSû Cj �SûCü�á �CûSû9Ï

ï�� ZãA�FaFRA�M�h�ÐÉÏq� 4OQSVLANMYÞ�D9E&?@:bB&ANM�FaÈW<WVaD9E�Fa:=F�Q�Ñ�A >CE&<\E�Ñ5QS8UD9E&]PANVa:=Va:=F Ç KW:=8a69F�BRQC8;E�]98;QCVaE�:^<æA�<P_À:=V;FÑ56\<PBRVa:=QS<PA�MfB;DPAN8LACBgVaE&8;:^ÊHA�Va:=QS<fÏ�� ���P� �t��3Rú�û����Cj �CüSûHá �Cû � Ï

ï�� � þ � �&®¶¨%�9�=���P� ��«5���=�Cög�U�%�H�a���^�g» Ï9Z�E&Í <9>SMØAN<P_ Ç :=QSMØANT9F�h Ç E&KCE&8;M=ÈÙÐÙ[�ú�ûCû 9Ïï 8�� e9AN?UT98aQWQSßJh7��Ï � Ï=h�ê\8a:=VaFRBaD�h Ϲê�Ï^h�Ð�AN<9:bA�V;:^FHh�4�Ïq� �\�½°R�H�a��»�«5�g�»4��N°É���^�N�9«b�W»É«b�À���^�H�&©�«5���`�L²g�a��°R��«b�

�Æ���=�R²&�W�^�N°����^���\«b�W» �Ö�Sö �Æ���\�Ô�N� Ï�Þ�QCMb_�eW]98a:=<9>UîYAN8aT`QC8 õ78aE&F;F�3Rú�û��SûCj�Ïï 8#7 eW:=E&>SE&M=?,AN<9<fhfî!Ï 4�Ïq�Uâã<|V;D9E�Þ�QC?@]\69VLANVa:=QC<PANM�õfQ�Í�E&8�Q�ÑdZ1E&698LANMYZ�E&V;F�Ï �W���W°&�`���Y�54à�%��©ã�P�S�a�&°����P�

��:H�R�a�&©÷�J²�«5���P²R�R� ���3LúHûCû Cjãú�ý���áJú���9Ïï 8 � eWD\QC8aEShYX�Ï^h Ç ANMb_WÍ�:=<fh ù Ϲí�Ïq� <9E&8;>CE&V;:ØBgF,QNÑ�XdZ1[ð4�Í�:=FaV;:=<9>PÏ �W���W°&�`���d�<4 �Æ���=�L²��W�^�N°���«5�N�^�g»~: úHü��

3Rú�û��SýCj�û SüHáÔû��9úSÏï 8��+��� eWV;8aÈSE&8�h`í�Ïq� �ër��²g�Ô��©�«Ø�L��°?:H���C°R�!¨Ã��«Ø�½«5�N�9� ÚiϹî�Ï9ê\8aE&E�?,A�<�A�<P_�Þ�Q`Ï9Z�E&Í �%QC8;ß�3Rú�û����Cj�Ïï 8��9ó� eWÊ�ȦT`A�M=FaßW:�h&ÚiÏ=h2�ã:=?Æh&Þ Ï��Ï^h�îãA�FLAN<fh�Z�Ï=h�õ�Q9_WDPA�×RFaßCA\h�[�Ï � Ïq�fÞ�MbA�F;F�Ò�cacaeã8aE&F;Va8;:ØBgVa:=QC<�E&<9Ê&ÈW?�E&F�ÒJA18aE&KW:=E&Í�Ï

� ���P� ú+� �U3Rú�ûSû9ú�j úHýHá �t�9Ïï 8����� eWÈWÊ&T`A�M=FaßW:�hfÚ Ïo�UI1<9:=KCE&8;FLA�M�8;E&FaV;8a:bBRV;:^QS<|E&<`_WQC<W6PBRM=E�ANFaE&FQ��_WE&F;:^>S<9:=<9>�<9Q�KSE&M�BRM=E�AHKCA�>SEUFa]`E�BR: ÌJBR:=Va:=E&FUTWÈ

BRQS?UT9:=<9:=<9>�AC_9AN]9VaE�8YQCM=:=>CQ9_WQHø9ÈW<9E&6`BRM=E&QCV;:Ø_ÔEYA�<P_�E&<9Ê�Ȧ?�E ?@QC:=E&V;:=E&F�Ï�� �&�P� � ��3LúHû�� Cjãú��Cû�áJúHüCý9Ïï21�3 47698;:^<\>PhW[�Ïq�7âã<ÆBRQC?�]969VRA�T9M=EY<W69?UT`E&8;F%Í�:=VaD�AN<ÙAN]9]9M=:bB&A�V;:=QC<UVaQUV;D9E <WV;FLB;D9E&:b_W69<\>CFa]\8aQCT\M^E�?Æh ��°L�H²&�

�Æ�H�r�¦�#�J��²��=������°&«5�g��� 3Rú�ûCý[�Cj�Ïï � ÿ� ÚÉE&:=<9E�8�hWÐÉϹõ7Ï^hWê\E&M=VaF�h ��Ï [�Ï=hWeW:=?,BRQHøfh�4�Ï �UÏ=h Ç 8LAN?,AN<fh � Ï¹Þ Ïo��[æ?@E&V;D9Q9_!Ñ5QC8�VaD9EãFa:=VaEgÒ´_W:=8;E�BRVaEH_�?@QS<9Q�Ò

AN<P_�?U69M=Va: Òf?U69VLAN>CE&<\E&Fa:=F�Q�Ñ#_ÔQC69T9M=ERÒ�FaV;8LAN<P_WE�_�X Z1[�Ï�� ���P� ú �t��3Lú�ûSûCýSj%ý Há � úCÏ

���

Page 29: q s q ->

ï � 7*� ÚÜ:bAS_WE&8aßW:=E&Í�:bBRÊCh ù Ï^h ù 69:=ÊRÒaÞ�A�8;:=M^M=Q`hC[�Ïo�ãÐ�:=Fa?,ANVLB;D,AN<P_�T9M=69<WVãVaQ@]\8aQCV;8a6P_Ô:^<\>�Ò�E&<P_�×RQC:=<9:=<9>�TWÈÙX Z1[M=:=>¦ANFaE&FHÏP� �9²&�=�&«r²Y� ²&«r� � �R���R��°R²R� ú�U3Rú�û��CüCj�ü��Cý\úRáÔü�� � �9Ï

ï � � � AN<,_WE�e9B;D9<\E&]9FLB;D9E�69V�h � Ϲí�Ï [�Ïq� µU�Ô�����%��©ã�P�S��«b�W»U«=�Ã� �b�9��öR�N�C��� 3LúHûCû � j�F;E�B�Ï7úCúSÏ 9Ïï � � � DPAN<9>Ph �ªÏ=h9eWE&E�?,A�<�hPZ�Ï¹Þ Ïq�7[ieWQSM^:b_SÒaeW69]\]PQS8aV�?@E�VaD9Q9_WQSM^QS>CÈ!Ñ5QC8�V;D9E�Þ�QS<9FaV;8a6PBRV;:=QC<�QNÑ �$E&QC?�E&Va8;:ØB�A�M

âãTC×RE�BgVaF�Ñr8aQC?qX Z�[�Ï �¦�N�W°&�P���7�54ã�r�Ô�ã� ©ª��°&«5²R���Ý�7�Ô��©�«5²R�N�`�J��²�«5�g��: úCú � 3Rú�ûSû��Cj �[� [�Há �[�t�Sý9Ï

�Cû