7/26/2019 Ringkasan Dermatology

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Viral Diseases

HerpesSimplexVirus(HSV)

Painful, recurrent vesiculareruption of mucocutaneoussurfaces

HSV-1: Oral-labial lesionsHSV-2:Genital lesions

Virus spreads throughepidermal cells fuse intogiant cells

Local host inammatory

responseerythema +selling

!nitial inf"n passed by direct contact virusremains dormant in local nerve ganglia

Primary episodes: longer, more severe thanrecurrences

Onset: preceded by prodromal tingling, burning,pain

#an also present $ lymphadenopathy, fever,

discomfort, malaise, edema

Recurrences: limited to mucocutaneous areasinnervated by involved nerve

%ecurrent oral &'(V-)*: common cold sore-cluster of crusted vesicles on erythematousbase .rigger: sun, fever

%ecurrent genital &'(V-/*: 0nilateral, cluster

of blisters on erythematous base, less pain +systemic involvement than primary

#linical

Tanc! smearofvesicle base:multinucleated giantcells

1V(V has sameappearance on .2anc3,so c" or direct !4 5bstaining needed forde6nitive d"

Oral or !V"cyclo#ir 4re7uency +

severity ofrecurrences

8aily acyclovir,famciclovirsuppressive therapy

Pts $ 9

outbrea3s peryear

Pts $ ;