Slide 3 Biotectix spun-out of the University of Michigan in
2007, originally based on technology for interfacing neural
prosthetic electrodes Biotectix is the leading provider of
conducting polymer coatings for cardiac, neuromodulation, and drug
delivery devices Biotectixs conducting polymer materials have a
history of preclinical safety and biocompatibility, with first
human use in 2011 Biotectix Snapshot BT DOT Conducting Polymers:
PEDOT-based proprietary material, formulated for increased
stability. Enhances stimulation and sensing by: Reducing interface
impedance Dual conductivity of electrons and ions High effective
surface area
Slide 4
Slide 4 Biotectixs Technology Product Pipeline Conductive
polymer electrode coatings for medical devices Medical devices and
components that leverage BT technology BT DOT Conducting polymer
electrode coating BT GelDOT 3-D conducting hydrogel coating BT
SituDOT Injectable biointegrated polymer electrode Polymer
electrode and conductive conduit BT DOT Sleeve BT DOT Coating
Conducting polymer electrode coating BT DOT Sleeve Polymer
electrode and conductive conduit BT GelDOT 3-D conducting hydrogel
BT SituDOT Injectible biointegrated conducting polymer Near-term
Long-term Low Q Med Q Hi Q
Slide 5
Slide 5 Comparison of BT DOT to TiN and bare PtIr Bare PtIr TiN
BT DOT Impedance (Ohm) Freq. (Hz) Current (mA) Voltage Lower
impedance: Up to 99% lower Lower noise Improved signal fidelity
Improved charge delivery capabilities Up to 10X higher than Pt or
PtIr Reduced electrode polarization Increased efficiency
Slide 6
Slide 6 Conducting Polymer Coatings Improve Sensing BT DOT
coatings reduce noise levels Enables microelectrode recording Makes
possible detection of small signals Improves neural activity
discrimination vs. Au, IrOx
Slide 7
Slide 7 BT DOT Coatings Increase Quantity and Amplitude of
MicroECoG Recordings BT DOT decreases electrode impedance, reduces
noise, and increases amplitude of neural recordings BT DOT
facilitates less invasive electrodes King, Lehmkhule, Dorval, et
al. Conducting polymer electrode coatings improve the in vivo
performance of microECoG arrays for neural applications. SfN. WDC.
2011. Impedance (Ohms) RMS Power
Slide 8
Slide 8 BT DOT Reduces Electrode Voltages, Polarization In
vitro and in vivo at 10 and 25 days after implant BT DOT-coated
electrodes reduce electrode polarization and voltage excursions by
>50% vs. IrOx In Vitro In Vivo Pulse: 45A, 200us (5 mC/cm 2 )
30A Wilks et al., PEDOT as a micro-neural interface material for
electrostimulation. Frontiers in Neuroengineering. 2009.
Slide 9
Slide 9 Biotectix Confidential Stimulation through PEDOT vs.
IrOx PEDOT-coated electrodes promote higher neuronal viability,
reduced astrocyte activity near stimulated neural microelectrodes
Cogan, Peramunage, Smirnov, Ehrlich, McCreery, Manoonkitiwongsa. In
vitro and in vivo performance of PEDOT neural stimulation
electrodes. Neural Interface Conference, Long Beach, CA. June,
2010
Slide 10
Slide 10 Biotectix Confidential Compliant electrodes High
conductivity (similar to BT DOT) Durable for equivalent of several
years in vivo Hydrophilic materials provide lubricity BT GelDOT
Coatings: Soft Electrodes Hydrated GelDOT
Slide 11
Slide 11 Novel BT Materials Can Enable New Lead Designs with
Reduced Precious Metal Use Biotectixs alternatives to precious
metal electrodes Flexible all-polymer electrodes BT DOT-coated SS
and MP35N electrodes electrically outperform Pt, reduces need for
precious metal electrodes 0.010 BT DOT Sleeve polymer conductive
tubing electrodes BT DOT-coated MP35N delivers more charge than
Pt
Slide 12
Slide 12 Biotectixs drug delivery technology enables on-demand
release Electrically-triggered drug delivery for precise control of
release of both neutral and charged drugs Biotectixs coatings
provide: Fast, on-demand drug delivery (at specified times/periods)
Delayed delivery (days to weeks after implantation) Responsive drug
delivery (in response to specific events) Stimulated release of
Dexamethasone (10s g in 60s)
Slide 13
Slide 13 BT SituDOT Bio-integrated Nanowire Polymer Electrode
Conducting polymer nanowires are deposited in situ from biomedical
electrodes to form intimate 3-D connection with target tissue. BT
SituDOT can Overcome encapsulation/insulating tissue reactions
Improve interfacing and connectivity with muscle, brain, bone,
cartilage Enable minimally-invasive injectable electrodes Low Q Med
Q Hi Q
Slide 14
Slide 14 Biotectixs Conducting Polymers Enable Many Cardiac and
Neuromodulation Devices BT technology addresses all
electrically-active devices A track record of successful
preclinical and FIH studies for multiple device platforms. Actively
engaging partners to explore applications in multiple clinical
areas
Slide 15
Slide 15 Conducting polymer coatings and electrodes can improve
device performance and safety while reducing device cost: Increased
sensing fidelity, reduced noise Increased stimulation capabilities,
reduced polarization Soft, compliant electrodes Drug delivery
capabilities Non-precious metal electrodes Biotectix is the leading
provider of medical conducting polymer coatings Biotectixs
materials have preclinical safety, biocompatibility, performance
Biotectix is currently engaging strategic partners to several areas
to codevelop new electrode technology for CRM, neuromodulation, and
drug delivery applications Summary
Slide 16
Slide 16 Jeff Hendricks, PhD [email protected]
www.biotectix.com Thank you!