Solution S1 Fardas 2012

7/30/2019 Solution S1 Fardas 2012

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solutions

zulfiayu

S1 Farmasi UNG Mei 2013


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definition

Homogeneous mixture that is prepared by

disolving a solid, liquid or gas in another liquid

and represent a group of the praparation in

substance are dispensed among those of the

solvent

A liquid preparation that contains one or more

soluble chemical substance dissolved in water


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definiton


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True Solution

The dispersed substance (the solute) and

dispersing medium (the solvent, the solution

phase contains the same chemical entity as

,the solvent, the solute is recovered unchange.


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Classification

Depending on the size of the dispersed particle :

a. True solution

b. Colloidal solution

c. Suspension


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Solubility

Kelarutan atau solubilitas adalah kemampuan suatu

zat kimia tertentu, zat terlarut (solute), untuk larut

dalam suatu pelarut (solvent). Kelarutan dinyatakan

dalam jumlah maksimum zat terlarut yang larut

dalam suatu pelarut pada kesetimbangan. Larutan

hasil disebut larutanjenuh. Zat-zat tertentu dapat

larut dengan perbandingan apapun terhadap suatu

pelarut. Contohnya adalah etanol di dalam air. Sifat

ini lebih dalam bahasa Inggris lebih tepatnya disebutmiscible.


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Solubility

Secara kuantitatif,kelarutan suatu zat

dinyatakan sebagai suatu konsentrasi zat

terlarut di dalam larutan jenuhnya pada suhu

.dalam satuan mililiter pelarut yang dapat

melarutkan satu gram zat. Misalnya 1 gr asam

salisilat akan larut dalam 550 ml air. Suatu

kelarutan juga dapat dinyatakan dalam satuanmolalitas, molaritas dan persen


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Solubility

Descritive Term Parts of solvent for 1 partof solute

Very soluble

Less than 1

From 1 to 10

Soluble

Sparingly soluble

Very slightly soluble

Partically insoluble orinsoluble

From 10 to 30

From 30 to 100

From 100 to 1000

From 1000 to 10.000

More than 10.000


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advantages

Patients in occasion ar unable to ingest a solid

dosage form

Therapeutic advantages

O er iversity in t e orm o me ication

Enhance effect of drugs rather in solid dosage

form


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disadvantages

Patient do not acces to accurate measuring

devices and a uniform volume from those o

another


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clasification

solution for internal use

solution for external use


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Internal use

Syrup

elixir


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Elixir

Combines the advantages of sweetness,

pleasant flavor and alcoholic content.

The alcoholic content may vary from as low as

- - .


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syrups

The tof syrups as vehicle has the advantages

of satisfactory masking of unpleasant tastes.

Sirup simplex?


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External use

Collyrium Collutorium

Collunarium

Gargle

Draught

Inhalation/aerosol

Injection

Enema

douche


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definition

Collyrium : solution intended to be used in the

eyes

Collutorium : solution intended to be used as

Collunarium : solution intended to be used in

the nose


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A gargle : solution intended to be used in the mouth

and throat

Spray and drops : solution intended to be

administered by being sprayed or dropped on th

affected area

Draught : intended to be taken as a single dose

Inhalation or aerosol : a solution of volatile

ingredients whose fumes are intended to be inhaled


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Injection : solution intended to be injected

into the body by means of a syringe.


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douches

An aqueous solution, used as an irrigation or

wash, whisch is applied a low pressure o

cleanse, deodorize, soohe, or medicate

, , . May promote healing, or be astringent,

antiseptic, or germicidal.

Used at vaginal tract, surgical prosedure, eye,

ear, nose,throat, bladder, colon, or kidney


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ENEMA

Placed in the rectum or colon to cause

evacuation or to bring a local or systemic

therapeutic ction.


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Solution S1 Fardas 2012