Neuroplasticitet og

Neurorehabilitering

Jens Bo NielsenInstitut for Neurovidenskab

Panum

Københavns Universitet

&

Elsassfonden

E-mail: JBNielsen@sund.ku.dk

Plasticity at three different levels

Engert & Bonhoeffer, Nature. 1999

Cellular Networks

Paul Bach-Y-Rita

Representational maps

Jeffrey Kleim

Training, learning Stabil hukommelse,

Varig forbedret præstationsevne

Consolidation (altered gene-expression

and protein synthesis)

Dopamine

Amphetamine

Reward

Nutrition

Sleep

Exercise

Stable memory

Lasting change in performance

Neuroplastic changes requires intensive and progressive training

over prolonged periods

Jesper

Lundbye-Jensen

Lasse Christiansen

Christiansen et al. 2018

Neuroplastic changes in relation to training as part of daily living

Treadmill training at home iPad training in stroke survivors Climbing

Willerslev-Olsen et al (2014; 2015; 2019)

Lorentzen et al. (2017) Christensen et al (2017)Larsen et al (2016; 2017)

Feasability study (n=18),

2.5 hr of activity 3 times pr

week in 3 weeks

15 children, 30 adults

Randomized, cross-over, follow-up

4 weeks training, 30 mins pr day

Using new technology to facilitate training at home

Babytraining - Caretoy Children – adults. MiTii

Sgandurra et al. (2014, 2016, 2017, 2019)

Significant improvement in IMP, visual acuity

and reduced parental stress

N=40

Blinded, randomized, cross-over

30 mins training pr day in 4 weeks

N=38

Blinded, cross-over

30 mins training pr day in 12 weeks

Significant improvement in AMPS and AHA, STS

Lorentzen et al. (2017)

New education: Master in Neurorehabilitation

Besøg Jakob Lorentzen i uddannelseshjørnet i Fordybelsesrummet