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ＳＰＧＳＰＧＳＰＧＳＰＧ Membrane Emulsification Membrane Emulsification Membrane Emulsification Membrane Emulsification ＳＰＧ Technology Co., Ltd.

http://www.spg-techno.co.jp/

The characteristics of SPG membrane emulsification is shown in the diagram below compared

with emulsification by a high pressure homogenizer. As it indicates, the SPG membrane

emulsification yield uniform emulsion droplets in a wide range of size, which suggests

monodispersion can be obtained. Thus, in consideration of production quantity in manufacturing,

the membrane is able to obtain various sized droplets in emulsion at a constant rate of 90%.

However, emulsification using the homogenizer will result in polydispersion due to several sized

droplets exisiton in emulsion, which implies that it is impossible to maintain steady yield efficiency

and productivity in manufacturing. For example, about 90% yield rate applies to the emulsion

with average particle diameter of 0.8μm, however, producing 6μm emulsion droplets, the rate

dropts to about 20% because of its wide distribution as shown in the following diagram②.

① SPG membrane Emulsion particle diameter distribution

② High-pressure homogenizer made by other company (excerpt from the catalog)

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SPGSPGSPGSPG Membrane Direct Emulsification Membrane Direct Emulsification Membrane Direct Emulsification Membrane Direct Emulsification

Disperse phase solution and continuous phase solution are prepared in a container respectively.

The disperse phase solution penetrate the SPG membrane producing uniform emulsion. The

continuous phase requires a slight current. The size of emulsion droplet will be about three

to four times bigger than that of the SPG pore .

Principal

Syringe type

1：Disperse phase tankDisperse phase tankDisperse phase tankDisperse phase tank 2：Disperse phase （Soybean oil） 3：Container for continuContainer for continuContainer for continuContainer for continuous phaseous phaseous phaseous phase

4：Continuous phase (contains an emulisifier)

5：SPG membrane 6：Stirring magnet 7：Stirrer

8:Gas pressure

1：SSSSyringe for disperse phaseyringe for disperse phaseyringe for disperse phaseyringe for disperse phase

2：Disperse phase （Soybean oil）

3：Vial for continuVial for continuVial for continuVial for continuousousousous phase phase phase phase

4：Continuous phase (contains an emulisifier)

5 ： SPG membrane 6 ： Stirring magnet

7：Stirrer 8:Pressure

8：Syringe pressure

8

2

7

1

4 5

6

3

2

4

7

5

6

8

1

3

Gas pressure type

current

Disperse phase

Continuous phase

SPG

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SPGSPGSPGSPG Membrane Membrane Membrane Membrane High Speed High Speed High Speed High Speed E E E Emlsificationmlsificationmlsificationmlsification(Premix)(Premix)(Premix)(Premix)

The disperse phase solution and continuous phase solution premixed roughly is penetrated to

yield uniform emulsion droplets.

The diameter of emulsion will be smaller than once or twice the size of the spg pore diameter.

※ 6：Stirring magnet and 7：Stirrer may be used in case by case.

Principal

1：、Tank 2：Dispers phase（Soybean oil）

3：Continuous phase Container 4:Continuous

phase (contains an emulisifier) 5 ： SPG

membrane 6：Stirring magnet 7：Stirrer

8：Gas pressure

1： Syringe、2： Dispers phase（Soybean oil）

3：Glass vial、4：Continuous phase (contains

emulisifier) 5 ： SPG membrane 6 ：Stirring

magnet 7：Stirrer 8：Preesure

Syringe type Gas pressure type

Continuous phase

Disperse phase

SPG

2

4

5

8

1

3

6

7

8

2

1

4

5

3

7

6

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SPGSPGSPGSPG Membrane Emulsification apparatus Membrane Emulsification apparatus Membrane Emulsification apparatus Membrane Emulsification apparatus

●SPGmembrane emulsification appartus（small to smaller size）

●Membrane emulisification homogenizer and SPG filter kit（for wo, for ow）

●SPG Membrane Emulsification Pumping Devices, etc

SPG Memb.

SPG Memb.

First emulisification Second emulisification

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Example: how to start Example: how to start Example: how to start Example: how to start SPGSPGSPGSPG membrane emulsification test membrane emulsification test membrane emulsification test membrane emulsification test First of all, the stability of emulsion needs to be confirmed by stirring for compsition of

dispersion/continious phase.

Dispersion phase and

Contineous phase

Recheck

stablized separated

1 2

1

2

1：Dispersion phase

2：Continuous phase （contains surfactant）

Dp

disribution

disribution

Dp

SPG pumping connector

（disposable）

SPG filter kit

（disposable）

Pressuring by

syringe

disribution

Dp

disribution

Dp

SPG memb.emulsification

（SPGchangable type）

Gas pressure

Stirring Adding Settled

1

2

1

2

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For selecting the scale of SPG module, you will need to determine the process capacity per

SPG unit length(emulsification speed for disperse phase and pressure force) based on the

usage of bench scale. Also, SPG effective length for desire production condition (proccessing

amount of dispersion phase, proccessing time) can be obtained by multipling SPG length times

the number of SPG tube.

Example

Emulsive condition for dispherse phase using selected SPG pore size is examined by the SPG

membrnae emulsification kit.

Process Capacity ①

Assuming: The SPG pore diameter 10μm

SPG effective length 1cm

Emulsification speed 10ml/(hours・cm)

Yield condition ①

Process amount of disperse phase =10ℓ, Time required for the process =4hours

From the above condition,

(Process amount of disperse phase =10ℓ）/(Emulsification speed10ml/time・cm)＝1000hours・cm

1000hours・cm/( Time required for the process= 4hours)＝250cm＝25cm25cm25cm25cm××××10101010tubestubestubestubes Module Module Module Modulessss

SPG Internal Pressure Formula micro kit

SPG effective length １cm

(Minute) regulator

Gas pressure

Pressure gauge

Stirrer

Continuous phase

Disperse phase tank

SPG module

SPG High Speed Minikit

SPG effective length １１cm

Circulating pump

SPG module

Tank for Continuous

phase

Tank for Continuous

phase

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Photos for Photos for Photos for Photos for SPGSPGSPGSPG Membrane Membrane Membrane Membrane Emulsification Equipment Emulsification Equipment Emulsification Equipment Emulsification Equipment （（（（MedMedMedMed----sizedsizedsizedsized））））

Disperse phase tank 2ℓ

Continuous phase tank 6ℓ

SPG module L250×7tubes

Disperse phase tank 5ℓ

Continuous phase tank 25ℓ

SPG module L500×30tubes

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Basically, the structure of this model is the same as one of the SPG high speed minikit.

SPG membrane emulsification Equipment

(med-sized)

SPG module with the several tubes

SPG module

Disperse phase

tank

Circulation pump

Observation

window

Collecting Emulsion

Controller

panel

Stirrer

Gas pressure

Contineous phase

tank