Supor® DCF™ Capsule Filters

Disposable capsule filters The Supor DCF capsules are self-contained, disposable capsule filters featuring double layer 0.1 μm or 0.2 μm Supor hydrophilic polyethersulfone membranes as used in SuporFlow® cartridges. Supor DCF capsules provide an economical solution to small-volume, high-efficiency filtration. They are manufactured for use under good manufacturing practice (GMP) and are integrity testable for quality assurance. Applications include sterile filtration, particle control, or prefiltration.

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Featuresu Double layer membrane construction

u 0.2 μm sterilizing grade capsules

u 0.1 μm sterilizing grade capsules for mycoplasma removal

u High flow rates and throughputs

u Available pre-sterilized by gamma irradiation

u Three sizes to meet requirements

u Broad chemical compatibility

u Low extractables

u Completely biosafe, non-toxic

u Manufactured for use in compliance with GMP

u Manufacturing Quality System Certified to ISO 9000 Standards

Applicationsu Sterile filtration of pharmaceuticals, biologicals, serum,

buffers and media

u Pharmaceutical product additives, bulk products and intermediates

u Recombinant proteins

u Water

SpecificationsMaterialsMembrane: double layer hydrophilic Supor polyethersulfone membraneSupport materials: polypropyleneHousing: polypropyleneFilling bell: polycarbonateSealing method: thermal bonding

Microbial Removal Ratings0.2 μm sterilizing grade (liquid)10.1 μm mycoplasma rated, sterile grade2

Filter Areas (Nominal)H series: 500 cm2 (0.54 ft2)F series: 1000 cm2 (1.1 ft2)S series: 1500 cm2 (1.6 ft2)

Dimensions (Nominal)Diameter: 6.9 cm (2.7 in.)

Overall Length (Without Adaptors)H series: 8.6 cm (3.4 in.)F series: 13.2 cm (5.2 in.)S series: 18.0 cm (7.1 in.)

Connections (Inlet/Outlet)313 mm (½ in.) hose barb6 – 13 mm (¼ – ½ in.) stepped hose barb38 mm (1 ½ in.) sanitary flange6 – 13 mm (¼ – ½ in.) stepped hose barb with filling bell (outlet only)

Typical Operating Characteristics4

Maximum operating pressure: 4.1 bar (60 psi) at ambient temperatureMaximum operating temperature: 60 °C at 2.1 bar (30 psi)

SterilizationAutoclavable to 121 °C Gamma irradiatableAvailable pre-sterilized by gamma irradiation

Warning: Capsules must not be steam sterilized in-situ by passing steam through under pressure.

Aqueous Extractables (NVR)5Typically, <15 mg

Quality/Bio-SafetyIntegrity (100% unit release test): Correlated to microbial retentionBiological tests: Meets USP biological reactivity, In vivo, for class VI-121 °C plasticsEffluent quality tests6

Meets cleanliness per USP Particulates in Injectables Non-fiber-releasing per 21 CFR Non-pyrogenic per USP bacterial endotoxins (<0.25 EU/mL) Meets total organic carbon and water conductivity per USP

purified water; pH per USP packaged watersSteam resistance: Samples multi-cycle autoclave challenged

Recommended Integrity TestMaximum forward flow limit7 0.2 μm: 3.1 bar (45 psi) H series: < 1.5 cc/min F series: < 3.0 cc/min S series: < 3.5 cc/min

0.1 μm: 3.4 bar (50 psi) H series: < 2 cc/min F series: < 4 cc/min S series: < 6 cc/min

Minimum bubble point0.2 μm: 3.52 bar (51 psi), water wet

PerformanceTypical Liquid Flow Rate (at 1 cP)0.2 µm H series: 0.55 L/min/0.1 bar F series: 1.1 L/min/0.1 bar S series: 1.6 L/min/0.1 bar

0.1 µm H series: 0.23 L/min/0.1 bar F series: 0.38 L/min/0.1 bar S series: 0.51 L/min/0.1 bar

Visit us on the Web at www.pall.com/biotechContact us at www.pall.com/contact

© 2019, Pall Corporation. Pall, , DCF, SuporFlow, and Supor are trademarks of Pall Corporation. ® indicates a trademark registered in the USA and TM indicates a common law trademark. Filtration. Separation. Solution. is a service mark of Pall Corporation.

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Corporate HeadquartersPort Washington, NY, USA+1.800.717.7255 toll free (USA)+1.516.484.5400 phone

European HeadquartersFribourg, Switzerland+41 (0)26 350 53 00 phone

Asia-Pacific HeadquartersSingapore+65 6389 6500 phone

International OfficesPall Corporation has offices and plants throughout the world in: Argentina, Australia, Austria, Belgium, Brazil, Canada, China, France, Germany, India, Indonesia, Ireland, Italy, Japan, Korea, Malaysia, New Zealand, Norway, Philippines, Poland, Russia, Singapore, South Africa, Spain, Sweden, Switzerland, Taiwan, Thailand, United Kingdom, and Vietnam. Distributors in all major industrial areas of the world. To locate the Pall office or distributor nearest you, visit www.pall.com/contact.

The information provided in this literature was reviewed for accuracy at the time of publication. Product data may be subject to change without notice. For current information consult your local Pall distributor or contact Pall directly.

Ordering InformationC S S Pore Inlet Outlet Code *EFA Code Rating Code Sterility** Code Fitting Code Fitting Code Quantity

H 500 cm2 92 0.2 µm P Non-sterile C 12.7 mm C 12.7 mm K*** 3/pkg (½ in.) (½ in.) hose barb hose barbF 1000 cm2 91 0.1 µm S Sterile P 6.4 – 12.7 mm P 6.4 – 12.7 mm L 25/pkg (¼ – ½ in.) (¼ – ½ in.) stepped barb stepped barb S 1500 cm2 R 38.0 mm R 38.0 mm (1½ in.) (1½ in.) sanitary flange sanitary flange Z 6.4 – 12.7 mm (¼ – ½ in.) stepped barb with filling bell

Note: For sizing or other information, please contact Pall

Specifications and availability: The information provided is a guide to the part number structure and possible options. Product availability may be subject to change without notice. All specifications are nominal. This literature was reviewed for accuracy at the time of publication. For current information on the products and test methodologies, consult your local Pall distributor.

References1Lot samples retain >107 cfu/cm2 of Brevundimonas diminuta per mod. ASTM F838 and FDA guidelines2Lot samples retain Brevundimonas diminuta per footnote 2 and >107 cfu/cm2 Acholeplasma laidlawii per mod. ASTM F8383Other fittings available upon request4Using compatible fluids5In water at 20 – 25 °C after autoclaving. Based upon the extraction of a 254 mm (10 in.) element6Per lot sample soak or rinse-up flush aliquot7Air test gas, water wet8Sterile filters are pre-sterilized by gamma irradiation

*Effective Filtration Area

**Sterile filters are sterilized by gamma irradiation

Other fittings, e.g., 1/4 in. Male NPT (Code D), 1/2 in. Male NPT (Code F) or 6 mm male quick connect (Code Q), available on request

***Supplied with capsule vent