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Supplemental Figure 1. Codon L576P CTT → CCT. Wild type. Mutation. Supplemental Figure 2. DM440 DM366. nM. 0 10 100 1000. 0 10 100 1000. Src. p- Src. FAK. p-FAK. P130. p-P130. DM6 DM738. Actin. WM3211. nM. - PowerPoint PPT Presentation
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Supplemental Figure 1.
Codon L576P CTT → CCT
Wild type Mutation
DM440 DM366
Srcp-Src
FAKp-FAKP130p-P130Actin
0 10 100 1000 0 10 100 1000nM
Srcp-SrcFAKp-FAKP130p-P130
Actin
DM6 DM738 0 10 100 1000 0 10 100 1000 0 10 100 1000nM
WM3211
Supplemental Figure 2.
Src-predicted dysregulation
% in
hibi
tion
of
cell
pro
life
rati
on
wit
h 10
00nM
das
atin
ib a
lone
Supplemental Figure 3.
0.1 0.2 0.3 0.4 0.5 0.6 0.7
-10
0
10
20
30
40
50
f(x) = 77.0862545040333 x − 18.8516123329777R² = 0.501655589597122
DM6
DM443
DM366
DM738
PRMel
DM440
Model1(Control)
0 4hr 8hr 16hr 24hr
Model 2
Model 3
Model 4
Model 5
Model 6
Model 7
Model 8
Harvest
Dasatinib Harvest
Dasatinib
Dasatinib
Dasatinib
Dasatinib
Dasatinib
Dasatinib
Harvest
Harvest
Harvest
Dasatinib
Dasatinib
Dasatinib Dasatinib
Harvest
Harvest
Harvest
Supplemental Figure 4.
Src
p-Src
FAKp-FAK
P130
p-P130
Actin
Model number1 2 3 4 5 6 7 8
A
B