Syllabus M-Pharm Pharmaceutics.pdf

8/10/2019 Syllabus M-Pharm Pharmaceutics.pdf

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TTAJASTH

HE,A.I-TH

SY

SCHEME

OF

COUR

FACULTY

O

M

First Sem

Second Sem

Third

Sem


3/15

Sy

llab

us : M

a st er

of

Pham

MASTERS

DEG

ACAD

l.

Duration

of

the

The

duration of

th

years

(four semest

include

first

semes

semester,

each

of

examination).

2.

Etigibility

for

ad

2.1

A candidate

who

h

(Aggregate

of

4 ye

SC/ST

candidate

examination)

from

2.2

Preference

will be

2.3

For

sponsored

can

A Pharmacy

Gradu

2.1

and

having

2

y

a

registered

phar

research institution

for

admission

und

Sponsored candida

fiom their

employe

The letter must also

with

the

sponsor

a

not

be

withdrawn

Sponsored

candidat


4/15

+

a

3.1

aa

J.L

4.

4.1

4.2

Raj

asthan

llniausity

of

I

lealth

S ciences

Scheme

of

StudY

&

Examination

The

medium

of

instruction

and

examination

slrall

bc

Bnglish.

Candidates

for the

M.Pharm

course

shall

be

instructed

ancl

examined

as

per

the

Teaching

and

Examination

Schcme

and

Course

Content

of

respective

specializations'

Eligibility

for

appearing

in

the

examination

Attendance

Requirement:

In

order to

be

eligible

for

University

examination,

a

student

must

be

present

in

not

less

than

75

ol

of theory

and

practical

classes

of

each

subject'

A

candidate

who

has attended

a

regular

course

of

study

for

the

first

semester

in an

academic

institution

shall

be

eligible

to

ufp"u.

at

the M'Pharm

first

semester

examination

of

the

University.

A

candidate

who

has

been

promoted

to

second

semester

as

per

the

provisions

for

conditions

of

passing

and

has

attended

a

."goiu,

"ourse

of

study

in

an academic

institution

for

the second

seirester

shall

be

eligible

to

appear

at second

semester

examination

for

M.Pharm.

A

candidate

who

has

been

promoted

to

third

semester

in

an

academic

institution

as

per

the

provisions

for

conditions

of

passing

and

has

completed

the

dissertation

research

work

up

io

the

satisfaction

of

the

superuisor

as

prescribed

under

the

relevant

regulations

for

third

semester

shall

be

eligible

to

appear

at

the

third

semester

examinati':n

for

M'Pharm'

Atthe

beginning

of

M.Pharm'

third

semester,

for each

candidate'

a

dissertation

supervisor

shall

be

appointed

by the

head

ofthe

shall

choose

a topic

for

dissertation

4.3

4.4

4.5

Syllabus:

Master

of

Phar

approval

ofthe

su

appointed

supervi

for

a

long

period,

th

sufervisor.

The

ca

on the

topic

appr

4.5 A candidate

who

the

provisions

for

dissertation

researc

as

prescribed un

semester

shall

b

examination

for

N

candidate

shall

co

third

semester.

5"

Sessional

(Inter

5.i

Theory sessionai

Written test

Seminar

and/or

as

Total

(i)

Written

test

At least

two

subject

sha

interval

dur

performance

purpose of

c

of each

wri

(ii)

an


5/15

5.3

5.4

Rajasthan

lJniaersil:y

of H

eulth

S

ciences

practical subject

shall

be

conducted

by

the

institute

at

regular

interval

during

each

semester.

The

avorage

of

best

tWo

performances

shall

be

taken

into

consideration

fbr

the

purpose

of

computation

of

practical

sessional

marks'

The

duration

of

each

practical

test

shall

be

or'6

hours.

Each

practical test

may

be

conducted

in

different

pafts viz'

synopsis/

spotting,

exercise/ experiment

and

viva-voce

etc.

(ii)

Day-to-day

practical

worV

experiments

performed

(10

marks):

The

concerned

teacher

shall evaluate

the

dayto-day

practical

work/

experiments

performed

in the

laboratory

on

the

basis

of the

performance

of

the

student'

viva-voce

and

maintenance

of

practical

record'

Professional

practice:

The students

shall

carry

out

professional

work

as

allotted

by the

head

of

the institution

in

M.Pharm.

first

and

second

semesters'

The

professional

work

shall

include

perforrna,rce

of

lab. dttties,

analysis

of

samples

etc.

Dissertation

sessional

(50

marks):

For M.Pharm.

third

and

final

semester

dissertation

sessional,

the

candidate

shall

submit

a copy

of

dissertation

progress

report

printed or tlpe

written,

containing

the

results

of

hisfter dissertration

research

work

duly

signed

by the

supervisor

and

forwarded

to

the

head

of

the

institution,

on or

before the

prescribed

date.

The

evaluation

shall

be

on the

basis

of

serninar

and

dissertation

Syllabas

:

Master of

Phann

A

candidate failing

to

improve

his /he

disserlation

by

appe

The aggregate

of

be

shail form

the basis

of irnproved session

in

the

practicals

can

a

regular course

of

University

examin

University

examinat

twice in a

year, as

and Course

Conten

or on

such

dates a

University examina

hours

duration"

The

out of

which

5

que

University examina

hours

duration

and

s

/ experiment and viv

send the

awards to

date

.

Dissertation

For M.Fharm.

thir

candidate

shall subr

or

type

written,

in

s

his/

her

dissertation

s.6

6.2

6.3

7.

7.1


6/15

8

llaiasthanllniaersity

of

Health

Sciences

written, in

bound form, containing

the nesults

of lris/

her research

work.

The dissertation

thesis shall

bear

a

certificate

from

the

supervisor

countersigned

and

duly

forwarded

by

tlre

Head

of

the

institution,

on

or

before

the

prescribed

date,

certifoing

that:

(i)

the

work has been

undertaken

and

cornpleted

and

the

dissertation

has

been

written

under

his/

her superttision

and

guidance

and

meets

the

requirements

uf

the

course;

(ii)

the

dissertation

is

a

bonctfide

record

of

the original

work

carried out

by the

candidate

and

the

di-ssertation

work

has

not

fornted

the

basis

of award

of

any

other

degree

or diplorna

etc.

of

this or

any

other

University.

The

evaluation

shall

be done

on the

basis of

dissertation

thesis,

presentation

and

viva voce

and

shall

be

done

by

a Board

consisting

of

dissertation

supervisor,

external

examiner

appointed

by the Universitv

and

the Head

of

the

institution

who

shall

be

the

chairman

of the

board.

The chairman

shall

then

send

the

awards

to

the University,

on

or before

the

prescribed date"

8.

Conditions

of

passing

8.1

A

candidate

shall

be

declared

to have

passed irr a sub.iect

when

he/ she

has

secured

50% of

the

maximum

marks

in the sessional

and

University

examination

marks

put

together

separately

in

each

theory

and

practical sub.jects

and

dissertation

sessional

and

dissertation

university

examination.

8.2

A

candidate who

fails

to obtain

500/o

marks

in

any

subject(s)

(Theory and

practical

counted

as

separate

subject)

in

first

or

S

y llabas

: M

ast

er

of

Pha

semester.

He/

sh

report

after

pursu

on the

same

diss

reappear

as an e

U

niversity

exam

i

8.5

A candidate,

w

examination, sha

a

clear

statemen

improvement.

He

thesis

after

incor

same dissertation

as an

ex-studen

examination.

In

no

case

shall

six

academic

yea

continue

the

cou

The Vice-chanc

institution

-;ray

reasons

for

waiv

extension

shall

A candidate

who

subject(s)

due

to

having

failed

in

Award

of

I)egr

On satisfactory

the semester

exa

8.6

8.1

9.

9.1


7/15

L0

60%*

or

above

50%

or iibove

9"3

OA

9"5

Raj

asthan

Uniaersity

of Health

Sciences

First

l)ivision

Second

Division

A candidat"e

will

be

said

to

have

passed

a

paper with

distinction

if ire/

she secure

75Yo

or

more

marks

in the

concenred

paper'

'Ihe

actual

marks

(and'not

the

passing

marks) as

obtained by

a

candidate

in

a

supplementary/atternpt

examination

shall

be

counted

for

award of division.

Rank

and

university

gold

rnedal.shall

be

conferred

to those

candidates

rviro

have passed

the

whole

examination

in

fir:st

attempt

(without

any

grace)

and

such

candidates

shall

be

eligibie

for

any

prize

or scholarship.

S

y

ll nbus

:

M

ast

er

of

Pha

Teachin

M.P

First semester

Paper

No.

M.PHIl3T

M.PI{l

l,lP

M.PHl

I5T

Subject

Research,

The

L{ethods

in P

Research,

Pra

Product

Devc

Theory

Product

Deve

Practical

Advanced

Ph

&

Biotechnol

ProfesSional

P

Total

*

These

hours

will

Second

semester

no

Papcr

No.

Subject

Advances

in

Pharmaceutic

including

Bio

Theoqv

Advances

in

Pharmaeeutic

M.l22P


8/15

12

Third

semesten

Ra

asthan

Unia

ersity

af

Heal

Paper

Subject

Teaching

Mar

No"

hrs.

per

Sessional

Llniv.E

Week

M.PH2I

lD

Dissertation

(Report,

Presentation &

Viva-voce) 'K 50 1

Finatr semester

Faper

Subject

Teaching

Mar

i\o.

hrs.

per

Sessional

Univ"E

M.PFD2lD

Dissertation

(Thesis,

Presentation

&

Viva-voce)

%

50

1

f-


9/15

:Mast*of

Phaflna

COU

,Pltgrrn

(Pharmaceutic

"uruoru.

lrharmacolory,

P

lrr

l

COM

lcmcster

,11

l'[

UV-Visible

spectros

r.

l,J V

-V

i s

ible

rang

tion

ol'electro--magn

,u,, ornd

its

utilizat

rtrills

and

their

interp

lc

spcctroscoPY.

Methods

in

Theory

Itt,

chromophores

and

lrn

ol'

organic

com

Itrl'ra-Rod

spectrosco

H{latiorr

with

organic

lAfla-roU

spectra,

brief

o

ifgfr:tnti()n

of

spectra

inc

tlve

irrterpretation

Htlvtutces

in I.R.

s

Nrrcleur

Magnetic

lpler

ol'NMR

(magn

on:

atrsorption

a

.

lirr:tors

affecting


10/15

20

Rajasthan

Unia

er

sity

of H

e

alth

and

frequency

domain signals,

nuclear

overhauser

enhanceme

NMR

spectra;

their

presentation,

characteristics,

interpretaticn,

and applications.

Brief indication

of

application

of,

magnetic

resonance

data

of

other

nuclei by modern

NMR

instruments,

introduction

D NMR techniques.

'

Mass Spectrornetry:

Basic

principles

and

brief

outli

instrumentation, ion formation

and

types;

molecular

ions,

rneta

ions,

fragrnentation

processes'

fragmentation

patterns and

characteristics

in

relation

to

parent

structure

and

functional

relativb

abundances

ofisotopes

and

their

contribution

to

cha

peaks, mass

spectrum;

its characteristics,

presentation

and

i

chemical

ionization

rnass

spectrometry

GC-MS

including

advances

in MS,

Fast

atom bombardment

mass

spectroscopy;

of

drugs

in

biological

sarnples

by

combined

GC-

MS.

Chromatography:

Basic

principles,

instrurnentation'

techniques

and

quantitative

analysis

of drugs

and their

using

column

chromatogaphy,

paper

chromatography,

TLC,

exchange chromatography,

GC,

GLC,

HPLC

and HPTLC.

Electrophoresis:

Moving

boundary

electrophoresis,

electrophoresis,

iso-tachophoresis,

iso-electric

focusing

and

electrophoresis.

Flourimetry

and

chemilumniscence:

Principles,

inst

and

applications;

electro-chemiluminescence'

resonant

ionization

I-aser-enhanced

ionization.

X-ray

crystallography,

thermal

methods

of analysis,

DSC,

eto.

Researeh,

tyllalun: Nlnster of

Phalm

ll.V./ Visible spectru

chrnrltliotr

and

correla

ltftrraltpltctricol,

analgin,

efter't

ul'

pll

and solvent

liclinrntion

of

single

dru

lnvnlving

dif

ferent

reagent

Doterrnination of UV

Firtinrution

of

single

lFotr(ll)hotometry.

Slrnultaneous

estimat

flg;nhirrntion

formulations

b

ffl$et

[rrrs/ derivative

spect

('untpnrison

of three

ffi

ulltor

drugs.

('alibration

of IR

spe

Sheehhrg

thc

performance

Recording

IR

spectra

ff

Phanrrucopoeia,

estima

lR

rpectra

of

simple

E:tiuration

of

drugs

,

llrtinration

of

drugs

Strur.:tural

elucidation

NMR

and Mass

spe

iemester

ltl'f

Advances

i


11/15

Experimental

Designs

:

lntroductiorrr

to

fu

l

l factorial

desi

gns,

centr

"ornporin"

designs,

"uJlution

of

full

antdreduced

mathematical

rnod'e

.---r:^^ :^-^

^^f

tha

pwnerirncnfsl

desiEnS

fi

in

experimental

designs,

applications

oof

the

experimental

designs

the

subjects

mentioned

"na"t

pharrrnainformatics'

introduction

22

Rai'asthunllniaersitg

ofHealth

contour

Plots.

search.

agents.

Pharmacopoeial

methods

for

evarluation

of

crude

drugs'

mono

po

lyherbal

formulation

s

by

F.O'

M'

deaterminatig'n'

L,O'

p''

"th

:.ilY

'"i*u"iin.

value,

phyomorphology,

mfi

croscopial

methods'

quantitati

microscopy,

quafit;tive

analysis,

pest:'icide

analysis'

Ti":"|:"t .":it:

Introduction

to

various

stages

ir:r

process

of

drug

develt

scope

and

aims

of

preclinical

and

clirnical

trials

for

drugs

and

Patents:

Definition,

need

forpatEnlting'

types

of

patents'

conditi

tobesatisfiedbyaninventiontobepatentable'introductiontopa

The

essential

elements

of

patent;;;

Guidelines

for

preparation

laboratory

notebook,

non

obviousnegs

in.

patent'.drafting

.of ,1at

claims,

imporant

patent

related

web-sites,

brief

introduction

to

protection

and

WTO

Patents.

lntrocluction

to 'The

Patent

Act

I

'970'

as amended

in

1999'2

&2005

and the

rules

made

there

und@r,

with

special

emphasis

on

forms

to

be

submitted

along

with

a

patent

application'

Biological

evaluation

of

the

foliovwing

classes

of

drugs:

analg

anti-inflammatory

agents,

tranquilizers,

hypoglycemic

agents

and

di

forms.

determinaiion

and

evaluation

uy

otherr

advanced

methods

like

uv,

GLC,

HPLC,

TLC,

&

HPTLC

etc';

automated

analysis

Syllabus:Masteraf

Pha

Shelf

life

study of

Evaluation

of

crud

Evaluation/

standar

Isolation, separatio

phytoconstituents.

Practical exercises

Chi-square

test,

first an

value, mean,

median,

mod

rule.

Curnulative

percen

sirnple

programs of

pha

Practical

exercises

research.

Preparing

protocols


12/15

M'Fllaren

(Fharxnaceutics)

Finst

semester

M.PH.Xtr3:f

Product

Develcpment',

T'heory

60

Hrs.

Fundamental

Aspects

of,

Froduct

Developrnent:

stmdies

ol'

weftabilib,.

solubility,

dissolution,

partiticn

and absorption,

surfactant

and

hydrocolloitls

and

their

role

in

drug

delivery

and targeting.

Deslgning

of

oral

Flrannaceuticals:

Formulation,

evaiuation,

stability

siu


13/15

Supposirories:

5e1";*tion

of

suppository

bases'

cirara*teristics

oI

bases,

"f,orrnulation,

preparation,

evaluation

ancl

pactrraging

tll

suppos

itones,

siabi

I

ifv

studies

and

necent

developrnen

t'

Derrnatological

Freparations:

Anatomy

and

physiology

of

skirr'

.rnechanismoiabseirptionthroughskinincludingmathematiealtreatmettt.

feirmuiaticrn

and

evaluation of

cintments,

creams,

paste,

gels

inciuding

herbal

cosrnetic

creams"

Stability

Studies:

Basic

concepts,

consideration

of

physical

antl

ctrernical

staUitity

studies,

determination

of

shelf

life'

problenrs

fLaj

*sthart

l.trttizt

wsity

of

Mealth

5

cience:t

encountered

during

storage

of dosages

forms'

M.PI{.114

P

Froduct

Developrment,

Practical

Validation

of

dissolution

test

apparatus'

Determination

af

molecular

weight

of'the

given

polymer.

Enhancement

of

solubility

of

the

given

drug

by

solid

dispersiott

technique"

Perferrrnance

of

powder

glass

test

on different

type

of

glasscs'

Perfbrmance

of,water

attack

on treated

soda

lirne

glass containcr'

Formulation

and

evaluation

of

matrix

tablet

of

given

drug'

Fon'nulation

and

characterization

of

topical

gels of

some

anti

inflammatory

drugs.

Comparison

of

reiease

rate

profile

of

conventional

and

sustaincd

release

tablets.

Preparationofmicroeapsulesbydifferenttechniquesandthcir

evaluaticn.

90

Hrs'

,,

i

,tl,

rt.

Alrrsfr,i

u.f Phaw

rr

l'tl

ll5tr'

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i'

l,,r

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and

pa

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p;rr'{ilioncoefficie

l'r,,rirrcliorr

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14/15

26

RaiasthanllniausitY

ofHealth

engineering,

applications

of recombinant

DNA

technology

in

vaccines,

hormcnes

production,

genetic disorders

and

gene

M'Pharrn

(Pharmaceutics)

Second

sernester

M.PII.123T

Novet

Drug

Delivery

System,

Theory

60

Polymers

and

their

Applications

in

Development

of

N

lntroduction,

basic

properties

ofbiodegradable

and

non

pol3rrners

and

their

uses.

Sustained

Release

Drug

Delivery

System:

Principle

i

advantages

and

disadvantages,

dose considerations,

physica

and

biological

properties

of

drugs

relevant

to

sustained

fonnulation,

niicro

eneapsulation,

evaluation

and

stability

studiee

SRDF.

Oral

Controlled

Drug

Delivery

Systems:

Principle

involved,

concept,

osmotic

pressure controlled,

membrane

permeation

pF{ independent,

iorl

exchange,

controlled

gel diffusion,

controlled

hydro dynamically

balanced

systerns,

evaluation.

Mucosal

Drug Delivery

System:

lntroduction,

anatomy

ph3,siology

of

oral

rtucosal,

meehanisrn

of

transrnucosal

and

mucous

membrane

models,

buccal,

nasal,

pulmonary

vaginal,

drug

clelivlry

systems.

delivery

of

peptides

pharmaceuticals.

Transderrnal

Drug

Delivery Systein:

Fundamentals

oftra

permeation

and

factors affecting

it,

permeation

enhancers,

deve

of transdermal

drug

delivery

systems,

evaluation

and

deveiopments.

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Ph

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metho

for

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statistical

concepts

Pharmacokin

compartnrentrrro

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renal

excretion,

he

absorption

kinetic

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k

Applicatinns

in

pharmacokineti

Documents

Syllabus M-Pharm Pharmaceutics.pdf