16
1 APS NEWSLETTER I JULY 2013 Conversion of Gabapentin to Pregabalin: Simple & easy! By Olly Zekry and Prof Stephan A. Schug Introduction Both Gabapentin and Pregabalin bind to the α 2 δ sub unit of voltage-dependent calcium channels, hence reducing the release of excitatory neurotransmitters such as glutamate. They both have analgesic, anticonvulsant, anxiolytic and sleep modulating activities. They are first line drugs for neuropathic pain including post herpetic neuralgia (PHN). Pregabalin is PBS listed in Australia for Editor’s Note Dear all, Contributors have not troubled your editor a great deal this month which is to say more articles would be welcomed. Fortunately our stalwarts, Olly Zekry and Stefan Schug, came to the rescue with a short article about dose equivalence when switching from gabapentin to pregabalin – a topical subject now that pregabalin is on the PBS. It has been pleasing to receive notifications about some recent publications: please keep the notifications coming. Also pleasing is the news that the Australian Physiotherapy Association has got firmly behind National Pain Week by making pain a key theme of their July newsletter – please see the short note about that. Regards, Will Howard Newsletter Editor NEWSLETTER JULY 2013 The Australian Pain Society Contents 2 CONVERSION OF GABAPENTIN TO PREGABALIN: SIMPLE & EASY! 4 ASM HOBART SUBMISSION DEADLINES 5 RECENT PUBLICATIONS 6 MAKING PAIN VISIBLE 8 NATIONAL PAIN WEEK 8 LINK BETWEEN PAIN AND IMMUNE SYSTEM 12 FYI + NEW MEMBERS 13 POSITION VACANT 14 CALANDER OF EVENTS 16 APS DIRECTORS + OFFICE BEARERS Volume 33, Issue 5 people with refractory neuropathic pain not controlled by other drugs (authority required), while Gabapentin is not PBS listed for neuropathic pain. Tolerance & adverse effects In general, Gabapentin and Pregabalin are well tolerated. The most common adverse effects reported in patients treated with Gabapentin and Pregabalin are dizziness, somnolence and peripheral oedema. Pharmacokinetics Although both are related chemically, Gabapentin shows non-linear pharmacokinetics, whereas Pregabalin shows linear pharmacokinetics. Table 1 - Pharmacokinetics of Gabapentin & Pregabalin Properties Gabapentin Pregabalin Oral bioavailability (Range) Low 42.0 — 57.0% High 83.9 — 97.7% Uptake Saturatable Linear over dose range Dosing interval TDS BD Excretion Renal Renal

the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

  • Upload
    others

  • View
    3

  • Download
    0

Embed Size (px)

Citation preview

Page 1: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

1APS NewSletter I JULY 2013

Conversion of Gabapentin to Pregabalin: Simple & easy!

By Olly Zekry and Prof Stephan A. Schug

Introduction

Both Gabapentin and Pregabalin bind to the α2δ sub unit of voltage-dependent calcium channels, hence reducing the release of excitatory neurotransmitters such as glutamate.

They both have analgesic, anticonvulsant, anxiolytic and sleep modulating activities. They are first line drugs for neuropathic pain including post herpetic neuralgia (PHN).

Pregabalin is PBS listed in Australia for

Editor’s Note

Dear all,

Contributors have not troubled your editor a great deal this month which is to say more articles would be welcomed. Fortunately our stalwarts, Olly Zekry and Stefan Schug, came to the rescue with a short article about dose equivalence when switching from gabapentin to pregabalin – a topical subject now that pregabalin is on the PBS. It has been pleasing to receive notifications about some recent publications: please keep the notifications coming. Also pleasing is the news that the Australian Physiotherapy Association has got firmly behind National Pain Week by making pain a key theme of their July newsletter – please see the short note about that.

Regards,

Will Howard

Newsletter Editor

NEwSlEttErJULY 2013the Australian Pain Society

Contents

2 CONVERSION OF GABAPENTIN TO PREGABALIN: SIMPLE & EASY!

4 ASM HOBART SUBMISSION DEADLINES

5 RECENT PUBLICATIONS

6 MAKING PAIN VISIBLE

8 NATIONAL PAIN WEEK

8 LINK BETWEEN PAIN AND IMMUNE SYSTEM

12 FYI + NEW MEMBERS

13 POSITION VACANT

14 CALANDER OF EVENTS

16 APS DIRECTORS + OFFICE BEARERS

Volume 33, Issue 5

people with refractory neuropathic pain not controlled by other drugs (authority required), while Gabapentin is not PBS listed for neuropathic pain.

Tolerance & adverse effects

In general, Gabapentin and Pregabalin are well tolerated.

The most common adverse effects reported in patients treated with Gabapentin and Pregabalin are dizziness, somnolence and peripheral oedema.

Pharmacokinetics

Although both are related chemically, Gabapentin shows non-linear pharmacokinetics, whereas Pregabalin shows linear pharmacokinetics.

Table 1 - Pharmacokinetics of Gabapentin & Pregabalin

Properties Gabapentin PregabalinOral bioavailability

(Range)

Low

42.0 — 57.0%

High

83.9 — 97.7%Uptake Saturatable Linear over dose rangeDosing interval TDS BDExcretion Renal Renal

Page 2: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

2APS NewSletter I JULY 2013

CoNVErSIoN of GAbAPENtIN to PrEGAbAlIN: SImPlE & EASy!

Switching from Gabapentin to Pregabalin

When switching from Gabapentin to Pregabalin as anticonvulsants, the dose should be tapered gradually over a minimum of a week to minimize the risk of increased seizure frequency.

A direct switch is recommended when the indication is neuropathic pain. Multiple studies show that direct conversion from Gabapentin to Pregabalin overnight is successful with no intolerable adverse effects noted at one week after conversion (Toth et al., Howard et al.).

In both studies conversion from Gabapentin to Pregabalin was achieved by discontinuation of Gabapentin therapy after an evening dose with initiation of Pregabalin therapy the following morning.

Dose equivalencies of Gabapentin and Pregabalin

The following conversion table was based on the assumption that Pregabalin has 6 times greater pharmacological effect against neuropathic pain than Gabapentin.

This assumption is crude as the saturatable uptake of Gabapentin makes conversion not always linear and dose adjustments need to be made.

Table 3 - Dose equivalencies of Gabapentin & Pregabalin for the conversion protocol

Daily dose of Gabapentin per day pre-switch(mg/day)

Daily dose of Pregabalin per day post-switch (mg/day)

Dosing schedule of Pregabalin

0 — 300 50 25 mg bd301 — 450 75 25 mg mane

50 mg nocte451 — 600 100 50 mg bd601 — 900 150 75 mg bd901 — 1200 200 100 mg bd1201 — 1500 250 100 mg mane

150 mg nocte1501 — 1800 300 150 mg bd1801 — 2100 350 150 mg mane

200 mg nocte2101 — 2400 400 200 mg bd2401 — 2700 450 150 mg mane

300 mg nocte2701 — 3000 500 200 mg mane

300 mg nocte3001 — 3600 600 300 mg bd

Table 2 - Indications for Gabapentin & Pregabalin

PainNeuropathic Pain

e.g. Peripheral Diabetic peripheral neuropathy,

Brachial plexus injury

Post surgical pain syndromesCentral Spinal cord injury

Post stroke pain syndromes

Pain associated with multiple sclerosisCombination Post herpetic neuralgia

Amputation painCancer pain Post chemo/radiotherapy

Opioid resistant painAcute pain Scoliosis surgery

Complicated traumaOther Fibromyalgia syndromeEpilepsy Complex partial seizures with or without generalization

Failed first line therapy (Valproate, Carbamazepine)

Adapted from Guidelines for Prescription of Pregabalin at Royal Melbourne Hospital – with permission.

Page 3: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

3APS NewSletter I JULY 2013

Creatinine Clearance (mL/min)

Maximum Dose of Gabapentin (mg)

Maximum Dose of Pregabalin (mg)

eClcr 26-50 300 bd 300 dailyeClcr 10-25 150 daily 150 dailyeClcr <10 300 q48h 75 daily

Conclusion

Direct switching from Gabapentin to Pregabalin in the treatment of neuropathic pain is supported by the current literature.. However, clinicians need to use clinical judgment with close monitoring of their patients to assess sustained efficacy and untoward adverse effects.

When switching from Gabapentin to Pregabalin for patients with seizure disorders, the dose should be reduced gradually over a minimum of one week in order to minimise the risk of increased seizure frequency.

references

1. Bockbrader H, Wesche D, Miller R, Chapel S, Janiczek N, et al. (2010). A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clinical Pharmacokinetics, 49(10), 661-669.

2. Bockbrader, H, Budhwani, M, Wesche, D. Gabapentin to Pregabalin Therapy Transition: A Pharmacokinetic Simulation. Am J Ther. 2013 Jan;20(1):32-6.

3. Cory Toth. (2010) Substitution of Gabapentin Therapy with Pregabalin Therapy in Neuropathic Pain due to Peripheral Neuropathy. Pain Medicine 2010; 11: 456–465. Wiley Periodicals, Inc.

4. Guidelines for Prescription of Pregabalin at Royal Melbourne Hospital.

5. Gabapentin Information Sheet.

6. Howard N. Bockbrader, Meeta N. Budhwani, and David L. Wesche, (2012) Gabapentin to Pregabalin Therapy Transition: A Pharmacokinetic Simulation. American Journal of Therapeutics, 1075–2765 _ 2012 Lippincott Williams & Wilkin.

7. Masataka Ifuku, Masako Iseki, Ikuhiro Hidaka, Yoshihito Morita, Syuji Komatus, Eiichi Inada (2011). Replacement of Gabapentin with

Pregabalin in Postherpetic Neuralgia Therapy. Pain Medicine: Volume 12, Issue 7, pages 1112–1116.

8. Pregabalin Information Sheet.

Olly Zekry

Olly is a clinical consultant pharmacist who works part time in RPA Hospital. She has also completed a Master in Chronic Pain through the Faculty of

Medicine, Sydney University. Olly has been a tutor for the PSA pharmacy interns since 2005 and contributes to the NSW Health ACI committee. Olly conducts home medication reviews for several medical centres in NSW, mainly in the Blue Mountains. She also runs educational workshops for RNs through the School of Nursing in NSW and workshops on pain management for GPs.

Stephan Schug

Stephan is currently Professor and Chair of Anaesthesiology in the School of Medicine and Pharmacology at the University of Western

Australia and Director of Pain Medicine at the Royal Perth Hospital, Australia. He also maintains a position as Honorary Professor of Anaesthesiology at the University of Auckland, New Zealand.

He studied medicine at the University of Cologne, Germany, where he obtained his MD by thesis in clinical pharmacology and subsequently specialised in anaesthesia, intensive care and pain medicine.

CoNVErSIoN of GAbAPENtIN to PrEGAbAlIN: SImPlE & EASy!

Table 4 - Dose adjustments of Gabapentin and Pregabalin

according to renal impairment

recognising the role of Pharmacists in Pain management

Nominations are now open for the Pharmaceutical Society of Australia’s Award for Quality Use of Medicines in Pain Management.

The PSA award is for a member pharmacist who is making an outstanding contribution to the quality use of medicines through direct clinical care in consumers with persistent pain.

To be considered for the award, pharmacists need to demonstrate that they have contributed to achieving one or more of the key goals of the National Pain Strategy.

The recipient of the 2013 PSA Award for QUM in Pain Management will receive registration fees, travel and accommodation to attend PAC13.

The award has been supported by a grant from Mundipharma.

Applications close on 2 August 2013.

For more information, click here.

Dose adjustments of Gabapentin and Pregabalin according to renal impairment

Page 4: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

4APS NewSletter I JULY 2013

ASm HobArt SUbmISSIoN DEADlINES

TOPICAL SESSION SUBMISSIONS NOW OPEN!On behalf of the Scientific Program Committee and the Local Organising Committee, we are pleased to advise topical session submissions for the APS 2014 ASM is now open.

The deadline for Topical Session submissions is: 1 AUGUST 2013.

View the topical session submission guidelines

Visit the online topical session submission page

ABSTRACT SUBMISSIONSAbstract Submissions for Free Papers and Posters will open on:

2 SEPTEMBER 2013

The deadline for Free Paper and Poster Submissions is:

31 OCTOBER 2013

We very much look forward to receiving your submissions. Should you have any queries regarding your submission or the process, please do not hesitate to contact

the Conference Secretariat.

Page 5: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

5APS NewSletter I JULY 2013

rECENt PUblICAtIoNS:

Thank you to Dr Michael Jennings, Psychiatrist in the Department of Consultation-Liaison Psychiatry and the Pain Management Centre at Royal Prince Alfred Hospital, Sydney NSW, who has provided this article.

Common psychiatric issues in chronic painThe article was primarily aimed at GPs. It discussed depression, anxiety disorders, somatisation, personality issues and substance abuse in patients with chronic pain, those who could be managed in primary care and those who could be referred to a pain clinic.

Jennings M. Common psychiatric issues in chronic pain Medicine Today 2013; 14 (3):55-58.

This article will also be included in a Medicine Today Pain Supplement to be issued in July 2013.

Thank you to A/Prof Kate Jackson, Director Supportive and Palliative Care, Southern Health and Monash University, and her fellow APS colleagues who have contributed to the following two publications:

1. JPSM - Merlina Sulistio and Kate Jackson. “Three weeks from diagnosis to death: the chaotic journey of a long term methadone maintenance patient with terminal cancer”. J Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print]

The palliative management, in particular pain management, of patients with opioid addiction presents unique challenges. The often associated complex psychosocial factors may add a further layer of difficulty in managing these patients; particularly those who wish to remain at home. We describe our three-week involvement in managing a patient with opioid addiction with newly diagnosed widespread metastatic cancer

and review the current guidelines for the palliative care management of terminally ill opioid addicts.

2. JCO letter – K Jackson, M Franco, L William, P Poon, M Pisasale, D Kenner, D Brumley, G Mewett and M Ashby. “Ketamine and Cancer Pain: The Reports of My Death Have Been Greatly Exaggerated”. JCO 2013; 31(10):1373-4. This letter is in reply to the JCO article “Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Toxicity of Subcutaneous Ketamine in the Management of Cancer Pain” by Hardy et al.

We countered, “In summary, we contend that the conclusions from the article by Hardy et al are valid only under the specific conditions of their protocol and do not necessarily apply to how we, and many others, use ketamine. We also suggest that the large body of contrary anecdotal evidence should not be dismissed without further investigation”.

Have you had an article accepted forpublication this year?

reminder that we are keen that members inform us when they have publications so that this can be shared with your APS colleagues. Please send the newsletter editor (via the APS Secretariat, [email protected]) the title, authors and reference (i.e. the journal, volume etc.) of the article, preferably with a short explanatory note to give our readers the gist of the article, e.g. the conclusions part of the abstract; if you would like to supply a short commentary on the article, even better.

will Howard, Editor

Page 6: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

6APS NewSletter I JULY 2013

mAKING PAIN VISIblE

making pain visible

This article has been reproduced with the kind permission of Painaustralia. It was first published in the Painaustralia eNewsletter Issue 21, 15 May 2013.

Researchers from the US claim that they have evidence that pain may leave a distinct “signature” in the brain that can be “seen” with specialised MRI scans.

When researchers exposed healthy volunteers to a painful dose of heat, it left a reliable pattern of brain activity that could be viewed on functional MRI (fMRI) – a type of imaging that charts changes in blood flow through the brain.

This “neurologic signature” was able to predict people’s subjective pain ratings with more than 90 percent accuracy, and it distinguished heat-induced pain from other feelings, like warmth and emotional pain.

However the study, which was published in the New England Journal of Medicine on 11 April 2013, looked only at short-term pain in healthy people.

Much prior work has shown that brief “experimental pain” in volunteers is very different to chronic pain in patients thus the neurosignature is different.

An Australian study led by Professors Philip Siddall and Michael Cousins in 2006 identified key brain areas associated with chronic low back pain and compared

these findings with the brain of people with no back pain using MRI and MRS (which shows biochemical changes in the brain).

This study reported that the brains of patients with low back pain could be discriminated from those without pain with an accuracy of more than 97 percent.

A later study by the same group made similar findings in people with spinal cord injury and neuropathic pain (nerve damage pain).

The findings suggest there may be a way to objectively measure people’s pain, rather than using the current subjective method of asking patients to rate their pain on a scale from one to 10.

This would have particular application where pain self report may not be reliable, such as in cases of mental illness or dementia. It could also complement patients’ self-assessment with an objective measure.

much prior work has shown that brief “experimental pain” in volunteers is very different to chronic pain in patients thus the neurosignature is different.

CUrrENt SCHolArS:

PhD Scholarship SponsorScholar

topic

mundipharma #3-APS-APrAAudrey wang“An investigation of the role of the brain in recovery from CrPS, using fmrI

PhD Scholarship SponsorScholar

topic

Janssen Cilag #2-APS-APrA Sarah Kissiwaa“Pain induced synaptic plasticity in the amygdala”

PhD Scholarship SponsorScholar

topic

APS #5-APrAJames Kang“Epigenetic influence in cognitive impairments in chronic neuropathic pain”

Page 7: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

7APS NewSletter I JULY 2013

PASt SCHolArS

PhD Scholarship SponsorScholar

Completedtopic

APS #1-APrA Samantha South 1999“Antinociceptive pharmacology of morphine and its major glucuronide metabolites”

PhD Scholarship SponsorScholar

Completedtopic

CSl #1-APS-APrAlara winter2004“Antinociceptive properties of the neurosteroid alphadolone”

PhD Scholarship SponsorScholar

Completedtopic

CSl #2-APS-APrAAnne Pitcher2006“Conditional comfort: A grounded theory study in nursing approaches to acknowledging and responding to pain in nursing home residents with dementia”

PhD Scholarship SponsorScholar

Completedtopic

mundipharma #1-APS-APrAKathryn Nicholson Perry2007“Pain management Programmes in Spinal Cord Injury: Cognitive behavioural Pain management Programmes in the management of Sub-acute and Chronic Spinal Cord Injury Pain”

PhD Scholarship SponsorScholar

Completedtopic

APS #2-APrA Debbie tsui2008“Preclinical studies in painful diabetic neuropathy”

PhD Scholarship SponsorScholar

Completedtopic

mundipharma #2-APS-APrAZoe brett2011“Individual differences in vulnerability to the development of chronic pain following injury”

PhD Scholarship SponsorScholar

Completedtopic

APS #3-APrA Susan Slatyer2013“Caring for patients experiencing episodes of severe pain in an acute care hospital: Nurses’ perspective”

PhD Scholarship SponsorScholar

Completedtopic

Janssen Cilag #1-APS-APrA mary robertsDue 2013“An investigation of the role of sleep in chronic pain”

PhD Scholarship SponsorScholar

Completedtopic

APS #4-APrAAmelia Edington2013“Defining inhibitor binding sites unique to the glycine transporter, Glyt2: A potential target for the treatment of chronic pain”

Page 8: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

8APS NewSletter I JULY 2013

NAtIoNAl PAIN wEEK

Australian Physiotherapy Association – Pain theme

the July edition of In motion, the monthly magazine of the Australian Physiotherapy Association (APA), will have a pain theme to correspond with National Pain week 22-28 July. It will include:

• A question and answer section by the APA’s CEO with Coralie Wales, founding member and acting president of Chronic Pain Australia

• A clinical case study by Tim Austin, physiotherapist and member of the APS

• A profile piece on Kathryn Refshauge who has a strong history of research studying chronicity and was recently appointed Dean of the Faculty of Health Sciences at the University of Sydney

• A feature profiling seven of the topical sessions at the Australian Pain Society’s 2013 annual scientific meeting

• A piece profiling Lorimer Moseley’s NHMRC-funded research project, ‘The imprecision hypothesis of chronic pain’

the link between Pain and the Immune System

This article has been reproduced with the kind permission of Painaustralia. It was first published in the Painaustralia eNewsletter Issue 21, 15 May 2013.

At the University of Adelaide, pioneering research is investigating a link between pain and the body’s immune system.

Over the past four years, Professor Paul Rolan and Dr Mark Hutchinson have combined their different specialist skills in research they hope will ultimately help to

improve treatment of chronic pain.

“All existing drug treatments are neuron-related and target the nerves or wiring of the pain system,” said Dr Hutchinson, a pharmacology scientist. “But in chronic pain the treatment is hit and miss and there are a high range of side effects.

“Our research demonstrates that the immune system may be a cause and that for patients with the right set of circumstances, pain medication actually makes their condition worse.”

The “eureka” moment in their research occurred when capsaicin – the fiery compound in chillies – was placed under the skin of volunteers. A subtle immune stimulant (endotoxin) was then given intravenously, showing that when the immune system was switched on it made the volunteers more sensitive to pain.

Another breakthrough was the discovery that codeine and morphine-like medications activate the glia immune system to create more pain in people with chronic headache.

And for women complaining of pain during their monthly cycle, the female hormone oestrogen is believed to be activating the immune pain cells.

The research team is now looking at a diagnostic blood test to identify people with an over-sensitive immune reaction to pain, and is assessing medications that might prove helpful.

The team is also testing the possibility of magnetically rewiring the chronic pain affected brain.

Read more

National Pain week 22-28 July 2013

This year Chronic Pain Australia will again host National Pain Week to reach out to even more people than last year. We know that people in pain often seek help through the internet and some-times this can be the only lifeline that they use when isolated at home due to pain. For those people we are running a Virtual Festival that we are calling the

“CyberFest of Hope”. We will screen one program a day across the internet with opportunities for people to comment and participate from their own homes.

On the other hand, many people in pain are, for one reason or another, unable to connect to the internet. For those people we are reaching out to local libraries to ask them to make their computers available for people in pain to go to their library to see these programs. The communique developed at the Painful Truths workshop will be released during National Pain Week and we are also building on the petition started in 2012. Pharmacies and libraries will have these petitions available for people to sign and send back to us. This year we should achieve that magic number – 10,000 – to ensure a debate in Federal Parliament about the impact of pain on the lives of people who live with it. If you would like a kit to promote National Pain Week, please contact us on [email protected]

Go to www.nationalpainweek.org.au for more information.

Page 9: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

9APS NewSletter I JULY 2013Sponsored)by:

The) INRC) Annual) Meeting) features) all) aspects) of) opioid) research) from) cellular) signaling,)molecular)biology)and)medicinal)chemistry)through)addiction)research)and)pain)management.))Since) 1969,) the) INRC) meeting) has) been) a) unique) forum) where) scientists,) clinicians) and)pharma)share) the) latest) information)about) the)key)questions) in)opioid) research.) )The)44th)annual)meeting)in)Cairns)is)a)great)chance)to)get)together)with)colleagues)old)and)new,)and)

Mark)Connor)and)Mac)ChristieCo-Chairs)INRC)2013

Key)DatesAbstract)submissions)open4)February)2013

Registrations)openMarch)2013

Abstract)submissions)close3)April)2013

Early)Bird)registrations)close10)May)2013))

Keynote)Speakers)

Discovery)Biology)Laboratory)Monash)Institute)of)

Actions)in)Forebrain)Regions

DC)Conferences

International)Narcotics)Research)Conference)2013)14-19)July)2013

Cairns,)Australia

!"#$%&'

$%("&$)

*+,-+.,/0%12.3%4%567,/0%186,%"9:9.3%1;28!0,-+0%<=->+-37=-%<+-36+

Page 10: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

10APS NewSletter I JULY 2013

12th Australian Palliative Care Conference

National Convention Centre, Canberra

3 - 6 September 2013

Palliative Care Australia

Palliative Care ACT

Pal lia

tive Care... everyone ’s business

s business

ePa

lliati

12th Australian Palliative Care ConferenceNational Convention Centre, Canberra3 - 6 September 2013

IMPORTANT DATES

Online Paper submission opens 18 February 2013

Online Paper submission DEADLINE 12 April 2013

www.dcconferences.com.au/apcc2013

Conference Announcement and Call for PapersSA

VE

TH

ED

AT

E

17–20 September 2013 | Sheraton on the Park, Sydney

Topic AreasAbstracts are encouraged from, but notrestricted to the following topic areas:

u Activity based rehabilitation

u Movement analysis/ Gait

u Mobilisation

u TBI

u Disaster Management

u Trauma

u Stroke Rehabilitation

u Pain Rehabilitation

u Prosthetics and Orthotics

u Upper Limb

u Restorative Therapies

u Occupational Rehabilitation

u Paediatric Rehabilitation

u Spinal Cord Injury

u Neuro-oncology

u Spasticity Management

u Health Care Services and Policy

u Developmental Disability

u Transition Care

u Musculoskeletal Medicine

u Measuring Outcomes

On behalf of the organising committee Iwould like to invite you to join us inSydney from 17-20 September 2013 at theAFRM 21st Annual Scientific meeting.

We’ve used our theme ‘Time to Move’ as alaunchpad to develop an interesting andchallenging programme exploring variousaspects of ‘movement’ and rehabilitation.

Of course in addition to the scientificprogramme and workshops, there will beopportunities to catch up with old friendsand meet new friends and to experiencethe local sights, sounds and tastes of theHarbour city. Sydney is always fabulousbut in Spring it shines.

I look forward to seeing you in September.

Dr Jennifer MannASM Convenor

IMPORTANT DATES: 11 March� On line abstract submission opens

13 May� Deadline for submission of

Free Papers and Posters. On line submission closes

� Registration opens

12 June� Notification of acceptance as

free paper or poster

2 July� Early Bird Deadline

For further information contact: AFRM Conference Secretariat: DC Conferences Pty LtdPO Box 637, North Sydney 2059 | Phone 612 9954 4400 | Fax 612 9954 0666Email: [email protected] line submission: www.dcconferences.com.au/afrm2013

WORKSHOP IN MEMORY OF BOB ELVEY

MAKING SENSE OF PAIN

For more information contact: [email protected]

PO Box 34, Wembley, WA 6913

CPD hours 16. Cost $640 (incl GST)Application form at: www.arthritiswa.org.au

Wyllie Arthritis Centre, 17 Lemnos St. Shenton Park, WA 6008

9-10 August 2013, 8.30 am–4.30 pm

This workshop will equip you with the skills and confidence to never again have a “heart-sink” patient

Presented byJohn Quintner (Physician in Rheumatology)Jane Muirhead (Occupational Therapist)Melanie Galbraith (Physiotherapist)Vance Locke (Psychologist)Mary Roberts (Psychologist)Shaun Fraser (Pain Champion)

Numbers limited

AOWA3a.indd 1 2/05/13 5:16 PM

WORKSHOP IN MEMORY OF BOB ELVEY

MAKING SENSE OF PAIN

For more information contact: [email protected]

PO Box 34, Wembley, WA 6913

CPD hours 16. Cost $640 (incl GST)Application form at: www.arthritiswa.org.au

Wyllie Arthritis Centre, 17 Lemnos St. Shenton Park, WA 6008

9-10 August 2013, 8.30 am–4.30 pm

This workshop will equip you with the skills and confidence to never again have a “heart-sink” patient

Presented byJohn Quintner (Physician in Rheumatology)Jane Muirhead (Occupational Therapist)Melanie Galbraith (Physiotherapist)Vance Locke (Psychologist)Mary Roberts (Psychologist)Shaun Fraser (Pain Champion)

Numbers limited

AOWA3a.indd 1 2/05/13 5:16 PM

Page 11: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

11APS NewSletter I JULY 2013

!"#$%&"$'()*#+#),#$(*!"#$-./&+0120)$'(11#3#$(*$4.+/#$5+0,&2&2()#+/

'()&0,&6$!"#$-'45$789:$'()*#+#),#$;#,+#&0+20&#6!"#$%&'()*+##,$-./.$#.01#,21"3!!4!!&6$56(!&!7789!99''!!!4!!<6!:::1+##,$-./.$#.01#,21"3;"#$%&'();!!""""!#$%&'(!)$$'*

<,=.>!?/"$+!@A"$#.>>,/B!<,C"/=!!4!!7=$>$7?$;#@&#AB#+C$789:

;-DE$!

FE$G-!

EH

You are cordially invited to the

models of Care in Chronic Pain rehabilitation workshop

running in conjunction with the 21st Annual Scientific meeting of the Australasian faculty of rehabilitation medicine

To register or for further information please visit,

www.dcconferences.com.au/afrm2013/Models_of_Care_in_Chronic_Pain_Rehabilitation

Topics Include:

A review of evidence-based self-management techniques

Discussion about the logistics and philosophies of both low and high-intensity programs

This workshop is aimed at rehabilitation physicians who are establishing & running pain programs

When: Tuesday 17 September 2013, 2.00 pm - 5.30 pm

Where: Sheraton on the Park, Sydney

Cost: $187 per person

Page 12: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

12APS NewSletter I JULY 2013

fyI + NEw mEmbErS

Want up to the minute information on the 2014 Australian Pain Society 34th Annual Scientific Meeting?Come follow us on Twitter… www.twitter.com/AusPainConf

fyI

Items of interest for our members:

• Di Crebbin personally, and her organisation DC Conferences, have provided outstanding service to the APS for many years. Di is soon to undertake the considerable challenge of climbing Mt Kilimanjaro to raise funds for Amnesty International. (Makes me breathless just thinking about it.) Members are invited to sponsor Di. The link is http://personalchallenge.gofundraise.com.au/page/CrebbinD

(Please note that the APS Newsletter does not usually promote events outside the aims of the Australian Pain Society but Di is a worthy exception.) Editor

• Painaustralia eNewsletter latest issue, available online at http://www.painaustralia.org.au/media-news/e-news.html

• Facility Directory Update Please advise the APS Secretariat of any updates so we may endeavour to keep the Facility Directory current: http://www.apsoc.org.au/facility-directory

• Survey – University of Queensland Topic: How men and women differ in the ways in which they experience and cope with their pain. Chief Investigator: Ms Nina El-Shormilisy Supervisors: Dr Pamela Meredith and Prof Jenny Strong Seeking participants who are 18 years of age or older and experiencing non-cancer chronic pain (more than 3 months duration) in any part of the body.

The survey is estimated to take 15 minutes to complete: https://www.surveymonkey.com/s/8LKCRT3

• Survey – La Trobe University, VIC Topic: The relative effectiveness of chronic pain management strategies used by adult community members. Student Investigator: Ms Lahna Bradley Staff Supervisor: A/Prof Pauleen Bennett Seeking participants over the age of 18 with a chronic pain disorder living in the community. The survey is estimated to take 15 minutes to complete. Participation deadline: 2 August 2013: http://latrobepsy.qualtrics.com/SE/?SID=SV_0P344RXcXLeDsJT

• National Pain Week 2013 22-28 July 2013 http://www.nationalpainweek.org.au

New member list:

title first Name Surname Craft Group

Dr ramony Chan Psychology

ms Nina El-Shormilisy occupational therapy

mr David field Psychology

mr michael Phelan Nursing

mrs louise rohloff Nursing

miss michelle rostas Physiotherapy

mr Greg troup Psychology

Page 13: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

13APS NewSletter I JULY 2013

PoSItIoNS VACANt

PoSItoN VACANt: Pain medicine Physician, Nambour General Hospital, QlD

• Enquiries: Dr Tania Morris (07) 5370 3566.• Job Ad Reference: H13SC06359• Application Kit: (07) 5370 3953 or www.health.qld.gov.au/workforus • Closing Date: Thursday, 15 August 2013

Duties/Abilities:

Provide specialist clinical care to patients and contribute to the responsibility for the delivery of a multidisciplinary specialist service in the area of Persistent Pain. Involvement in educational and research activities of the Persistent Pain Management Service, including assistance in coordination of specialist training in the discipline of Pain Medicine. Nambour General Hospital is a major regional teaching hospital serving a population of approximately 300 000 residents and holiday makers and is located on the Sunshine Coast, an area well known for its relaxed lifestyle and abundance of natural beauty and attractions.

Position:

Senior Staff Specialist or Staff Specialist (Pain Medicine Physician), Persistent Pain Management Service, Surgical Service Group, Nambour General Hospital, Sunshine Coast Hospital and Health Service. Remuneration value up to $396 035 p.a., comprising salary between $180 786 - $191 675 p.a., (L25-L27) or remuneration value up to $365 165 p.a., comprising salary between $151 177 - $175 602 p.a., employer contribution to superannuation (up to 12.75%) and annual leave loading (17.5%) private use of fully maintained vehicle, communications package, professional development allowance, professional development leave 3.6 weeks p.a., professional indemnity cover, private practice arrangements plus overtime and on-call allowances. (Full time or part time, hours negotiable. Applications remain current for 12 months. Please note: only applications from candidates will be accepted; applications that may result in an agency fee will not be considered).

Holy Grail Quest for the

Personalised Pain Management:

2014 Australian Pain Society 34th Annual Scientific Meeting13 -16 April 2014Hotel Grand Chancellor, Hobart

S U B M I S S I O N D E A D L I N E S

Topical Sessions 1 August 2013

Free Papers & Posters 31 October 2013

Early Bird Registration 14 February 2014

Page 14: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

14APS NewSletter I JULY 2013

CAlENDAr of EVENtS10 Jul 2013

University of melbourne $6 billion woman and $600 million girl: neurobiology of pelvic pain Sunderland Lecture Theatre, University of Melbourne, Parkville VIC Website>

14-19 Jul 2013

International Narcotics research Conference 2013 Annual Meeting Pullman Cairns International, Cairns QLD http://www.dcconferences.com.au/inrc2013

19 Jul 2013

PmrI windows on Pain luncheon 2013 Soaring Above Pain NSW Parliament House, Sydney NSW http://www.trybooking.com/CQNF

22-27 Jul 2013

Chronic Pain Australia National Pain Week, National Pain Week 2013 http://www.nationalpainweek.org.au/

24-26 Jul 2013

ot Australia 25th National Conference and Exhibition Creating a Unified Foundation for our Profession: Research, Practice, Education Adelaide Convention Centre, Adelaide SA http://otaconference.com.au

25-27 Jul 2013

Cancer Nurses Society of Australia 16th winter Congress Connecting Cancer Care Brisbane Convention and Exhibition Centre, Brisbane QLD http://www.cnsawintercongress.com.au

4-8 Aug 2013

oxford round table Health, Nursing, Aging and Nutrition Oxford University, Oxford UK http://www.oxfordroundtable.com/index.php/view/Sessions-Item/id/176

9-10 Aug 2013

Arthritis & osteoporosis wA Making Sense of Pain Wyllie Arthritis Centre, Shenton Park WA http://arthritiswa.org.au/

21-23 Aug 2013

Australian & New Zealand Spinal Cord Society (ANZCoS) 2013 Annual Scientific meeting New solutions in a Changing World Sydney Convention Centre, Sydney NSW http://www.dcconferences.com.au/anzscos2013

3-6 Sep 2013

Palliative Care Australia and Palliative Care ACt Palliative Care ... everyone’s business National Convention Centre, Canberra ACT http://www.dcconferences.com.au/apcc2013

17-20 Sep 2013

Australasian faculty of rehabilitation medicine 21st Annual Scientific meeting Time to Move Sheraton on the Park, Sydney NSW http://www.dcconferences.com.au/afrm2013

17 Sep 2013

Australasian faculty of rehabilitation medicine 21st Annual Scientific meeting Models of Care in Chronic Pain Rehabilitation Workshop Sheraton on the Park, Sydney NSW http://www.dcconferences.com.au/afrm2013/Models_of_Care_in_Chronic_Pain_Rehabilitation

24-27 Sep 2013

Australian College of Nurse Practitioners Nurse Practitioners Across the Lifespan, Transforming Healthcare Hotel Grand Chancellor, Hobart TAS http://www.dcconferences.com.au/acnp2013

3-6 oct 2013

International multidisciplinary forum on Palliative Care The 2nd International Multidisciplinary Forum on Palliative Care (IMFPC 2013) Kempinski Hotel, Sofia Bulgaria http://www.imfpc.org

8-12 oct 2013

Australian Psychological Society 48th Annual Conference Cairns Convention Centre, Cairns QLD http://www.apsconference.com.au

9-12 oct 2013

European federation of IASP Chapters (EfIC) 8th biennial Congress Pain in Europe VIII Firenze Fiera S.p.A. Congress & Exhibition Center, Florence Italy http://www1.kenes.com/efic

17-19 oct 2013

the rACGP Conference for General Practice GP13 Darwin Convention Centre, Darwin NT http://gpconference.com.au/gp13

17-20 oct 2013

Australian Physiotherapy Association Conference 2013 New Moves Melbourne Convention and Exhibition Centre, Melbourne VIC http://www.physiotherapy.asn.au/Conference2013

18 oct 2013

Pain Interest Group - Nursing Issues PIG-NI Faces of Pain Le Montage, Lilyfield, Sydney NSW https://www.dcconferences.com.au/pigni2013

Page 15: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

15APS NewSletter I JULY 2013

19-24 Jan 2014

london Pain forum Winter Symposium Hotel Village Montana, Tignes France http://www.lpfwintersymposium.blogspot.com

13-16 Apr 2014

Australian Pain Society 34th Annual Scientific meeting Personalised Pain Management: Quest for the Holy Grail Hotel Grand Chancellor, Hobart TAS http://http://www.dcconferences.com.au/aps2014/

30 Apr - 3 may 2014

5th world Anaesthesia Convention NwAC 2104 Monitoring and Patient Safety in Anesthesiology - updating technology and saftey protocols Reed Messe Wien GmbH Congress Center, Vienna Austria http://www.nwac.org/convention-information/nwac-2014

1-4 oct 2014

lievensberg Hospital, Holland 4th Biannual International Multidisciplinary Pain Congress Van der Valk Hotel Eindhoven, Eindhoven The Netherlands http://www.paincongress.org

7-11 oct 2014

International Association for the Study of Pain (IASP) 15th World Congress on Pain La Rural Convention Centre, Buenos Aires Argentina http://www.iasp-pain.org/Content/NavigationMenuWorldCongressonPain2/ 15thWorldCongressonPain/default.htm

Page 16: the Australian Pain Society JULY 2013 NEwSlEttEr · Pain Symptom Manage. 2013 Feb 1. pii: S0885-3924(12)00835-4. doi: 10.1016/j.jpainsymman.2012.10.231. [Epub ahead of print] The

16APS NewSletter I JULY 2013

APS DIrECtorS & offICE bEArErS 2013

Directors: office bearers :

President: Dr Malcolm Hogg Department of Anaesthesia and Pain Management Royal Melbourne Hospital, Parkville VIC 3052 Tel: 03 9342 7540 Fax: 03 9342 8623

QlD Director: Ms Trudy Maunsell Princess Alexandra Hospital 199 Ipswich Road Woolloongabba QLD 4102 Tel: 07 3176 5547 Fax: 07 3176 5102

Immediate Past President: Dr Tim Semple Royal Adelaide Hospital Pain Clinic North Terrace Adelaide SA 5000 Tel: 08 8222 5403 Fax: 08 8222 5904

President-Elect: Dr Geoffrey Speldewinde Capital Rehabilitation Multidisciplinary Injury & Pain Management Centre 25 Napier Close Deakin ACT 2600 Tel: 02 6282 6240 Fax: 02 6282 5510

SA Director: Ms Anne Burke Royal Adelaide Hospital Pain Clinic North Terrace Adelaide SA 5000 Tel: 08 8222 4770 Fax: 08 8222 5904

SPC Chair: Professor Michele Sterling Centre for National Research on Disability and Rehabilitation Medicine (CONROD), Ground Floor, Edith Cavell Building Royal Brisbane Hospital QLD 4029 Tel: 07 3365 5344 Fax: 07 3346 4603

Secretary: Mr Michael Deen Metro South Persistent Pain Management Service Level 3, 57 Sanders Street Upper Mount Gravatt QLD 4122 Tel: 07 3339 5500 Fax: 07 3339 5599

tAS Director: Dr Michele Callisaya Physiotherapy Department Royal Hobart Hospital Liverpool Street Hobart TAS 7000 Tel: 03 6222 8634

IASP liaison: Professor Michael Nicholas Pain Management Research Institute Royal North Shore Hospital St Leonards NSW 2065 Tel: 02 9926 7894 Fax: 02 9662 6279 Website: www.iasp–pain.org

treasurer: Dr Gavin Chin Royal Darwin Hospital PO Box 41326, Casuarina NT 0811 Tel: 08 8922 8888 Fax: 08 8922 8900

VIC Director: Dr Richard Sullivan Peter MacCallum Cancer Centre – East Melbourne Locked Bag 1, A’Beckett Street VIC 8006 Tel: 03 9656 1111 Fax: 03 9656 1400

website/Social media Coordinator: Dr Richard Sullivan Peter MacCallum Cancer Centre – East Melbourne Locked Bag 1, A’Beckett Street VIC 8006 Tel: 03 9656 1111 Fax: 03 9656 1400

ACt Director: Mrs Joy Burdack Calvery Health Care ACT PO Box 254 Jamison Centre ACT 2614 Tel: 02 6201 6854 Fax: 02 6201 6949

wA Director: Dr Stephanie Davies Anaesthetic Department and Pain Medicine Unit Fremantle Hospital Health Service Alma St, Perth WA 6160 Tel: 08 9431 3296 Fax: 08 9431 3696

Newsletter Editor: Dr William Howard Department of Anaesthesia Austin Health Studley Road, Heidelberg VIC 3084 Tel: 03 9496 3800 Fax: 03 9459 6421

NSw Director: Ms Fiona Hodson Hunter Integrated Pain Service John Hunter Hospital and Royal Newcastle Centre PO Box 664J Newcastle NSW 2300 Tel: 02 4922 3435 Fax: 02 4922 3438

PhD Scholarship Chair: Professor Maree Smith Centre for Integrated Preclinical Drug Development University of Queensland St Lucia QLD 4072 Tel: 07 3365 2554 Fax: 07 3365 1688

Nt Director: Ms Jenny Phillips Acute Pain Service, Royal Darwin Hospital PO Box 41326, Casuarina NT 0811 Tel: 08 8922 8888 Fax: 08 8922 8325

Secretariat: DC Conferences Pty Ltd PO Box 637, North Sydney, NSW 2059 Tel: 02 9016 4343 Fax: 02 9954 0666 Email: [email protected]