Università degli Studi di TORINO Ricerca scientifica ... · Università degli Studi di TORINO Ricerca scientifica finanziata dell'Università ... The scientific activity of Prof

Università degli Studi di TORINO

Ricerca scientifica finanziata dell'Università

Anno presentazione richiesta 2011

Project Id: ORTO11RRT5

1 Project general informations

1.1 Starting date (year) 2011

1.2 Duration 24 months

1.3 Type of request Track A

1.4 Scientific Field (MacroArea) I. Formal and Experimental Sciences and Technologies

2 Research theme

1.Micro and nanostructures

3 Title

Advances in nanostructured materials and interfaces for key technologies

3 Titolo

Materiali nanostrutturati e interfacce per tecnologie di frontiera

4 ERC codes

PE Physical Sciences and Engineering

PE4 Physical and Analytical Chemical sciences: analytical chemistry, chemical theory, physical

MODELLO http://unitorino.cineca.it/php5/compilazione11/vis_modello.php?codic...

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chemistry/chemical physics

PE4_4 Surface science and nanostructures

PE5 Materials and Synthesis: materials synthesis, structure-properties relations, functional and

advanced materials, molecular architecture, organic chemistry

PE5_3 Surface modification

PE4 Physical and Analytical Chemical sciences: analytical chemistry, chemical theory, physical

chemistry/chemical physics

PE4_2 Spectroscopic and spectrometric techniques PE4_13 Theoretical and computational chemistry

PE5 Materials and Synthesis: materials synthesis, structure-properties relations, functional and

advanced materials, molecular architecture, organic chemistry

PE5_6 New materials: oxides, alloys, composite, organic-inorganic hybrid, nanoparticles

5 Key words

Nanostructured interfaces and surfaces

surface structure properties relationships

solid-solid interfaces

solid-gas interfaces

solid-liquid interfaces

micro-nano patterning

nanoparticles

Nano-biointerfaces

Characterization at atomic/molecular level

ab-initio modelling

6 Abstract for dissemination activities

Surfaces and interfaces give objects their shape and texture. At all length scales and in part of matter asdiverse as a piece of metal, a device or a living cell, a close-up look will reveal a fine structure made ofboundaries and domains. The structure, chemical reactivity and physical properties of surfaces andinterfaces largely determine properties of materials. The deliberate design and fabrication of surfaces andinterfaces at the atomic, nano- and micro-meter scale has been recognized as central in national andinternational research programs and has lead to the establishing of the “Centre of Excellence on


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Nanostructured Surfaces and Interfaces” (NIS) at the University of Torino in 2001. The present applicationhas the objective of strengthening its research activities in selected areas, strategic to the development offuture technologies, by taking up “new blood”, i. e. young researchers, and funding the use of commonresearch tools such as electron microscopes, diffraction equipments, spectrophotometers, thermalanalyzers, computer clusters, testing devices installed over recent years. The research topics include:- bulk materials for electronic, electric, mechanical devices where solid-solid interfaces are of paramountrelevance: patterned diamond and superconductors, nanocrystalline alloys and composites, photo-activesemiconductors;- chemically functionalized solids for solid-gas or liquid interaction to address catalytic processes andenvironmental issues: materials for capture and encapsulation of small molecules, zeolites, photo-catalysts;- nano-bio-interfaces to be tailored and studied for in situ and in vivo diagnostics and therapeutics, implantsand biosensors: nanohydroxyapatites, bio-glasses and silica, porous silicon and diamond sensors.The management of the project is planned via the structures of the NIS Centre. Initiatives for projectmonitoring and technology transfer will be taken by using the established tool of NIS Colloquia.

6 Riassunto del progetto per scopi divulgativi

Le superfici e le interfacce forniscono alla materia forma e consistenza. A tutti i livelli di scala e in sostanzediverse, un metallo, un dispositivo o una cellula vivente, l’osservazione ravvicinata rivela una struttura fattadi bordi e domini. Struttura, reattività chimica e proprietà fisiche di superfici ed interfacce determinano molteproprietà dei materiali. La progettazione e realizzazione di superfici ed interfacce a livello atomico, dellanano- e micro- scala sono centrali in programmi di ricerca nazionali ed internazionali e hanno portato allacostituzione del "Centro di Eccellenza sulle Superfici ed Interfacce Nanostrutturate" (NIS) presso l'Universitàdi Torino nel 2001.Questo progetto ha l'obiettivo di rafforzare l’attività del Centro in settori di ricerca selezionati, strategici perlo sviluppo di tecnologie, infondendo "nuova linfa", cioè giovani ricercatori, e finanziando l'uso distrumentazione comune installati negli ultimi anni come microscopi elettronici, attrezzature di diffrazione, perl’analisi termica, spettrofotometri, cluster di computer. I temi di ricerca sono:- materiali massivi per dispositivi elettronici, elettrici, meccanici in cui le interfacce solido-solido sono dirilevanza fondamentale: “pattern” su diamante e superconduttori, leghe e compositi nanocristallini,semiconduttori foto-attivi;- solidi chimicamente funzionalizzati per interazione solido-gas o liquido per l’uso in processi catalitici edapplicazioni ambientali: materiali per la cattura e l'incapsulamento di piccole molecole, zeoliti,foto-catalizzatori;- nano-bio-interfacce progettate e studiate per diagnostica in situ e terapia in vivo, impianti e biosensori:nanoidrossiapatiti, bio-vetri e silice, sensori in silicio poroso e diamante.Si prevede di gestire il progetto mediante le strutture del Centro NIS. Saranno prese iniziative per ilmonitoraggio del progetto e il trasferimento tecnologico utilizzando lo strumento già collaudato dei NISColloquia.

7 Principal investigator (PI)

BORDIGA

(Surname)

Silvia

(Name)

Associate

professor

(Tipology)

CHIM/02

(Settore scient. Discipl.)


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28/04/1964

(Date of birth)

BRDSLV64D68L219A

(Personal identification code)

CHIMICA I.F.M.

(Department)

0116708373

(Telephone)

(Fax)

[email protected]

(Email)

8 Principal investigator curriculum

Silvia Bordiga (degree in Chemistry in 1988 and PhD in 1993at the University of Torino) is Associateprofessor in Physical Chemistry at the Faculty of Sciences of the University of Turin since July 2001. Herteaching activities refer to heterogeneous catalysis, and spectroscopies considering both theory andapplications. She was and is supervisor of many degrees and master thesis in Chemistry, IndustrialChemistry, Materials Science, and 9 Ph.D in Material Science. The scientific activity of Prof. Bordiga ismainly devoted to the characterization of the physical-chemical properties of high surface area materialsand in particular of oxides, zeolites and MOFs, with a particular attention to their surface properties. Thestudies are mainly related with spectroscopic characterization through vibrational and electronicspectroscopies both in absorbance (IR ed UN-Vis-NIR, EXAFS and XANES), scattering (DRIFT e Raman),and in emission (Luminescece). Research interests of Professor Bordiga are devoted to nanostructuredmaterials with large surface area used ad heterogeneous catalysts, photo-catalysts, materials foradsorption, separation and storage. The development of Raman-spectroscopy laboratory, where 3 microRaman Renishaw instruments equipped with 5 sources laser are available, has broaden her interests towardtopics closer to the biology area, such as bioactive materials. She is also strongly involved in experimentsexploiting synchrotron radiation facilities. The large experience in the use of EXAFS in catalysis gave herthe possibility to be part of the Chemistry committee of ESRF Synchrotron radiation facility in the period2004-2007, being chairwoman in 2007. She was participating as scientific leader to a STREP project in theframe of the VI Framework programs and to a COLLABORATIVE (Large-scale integrating project)NANOMOF of the VII Framework programs of the European Community. Both these projects are related to anew class of microporous materials known as Metallorganic frameworks (MOFs), an area where SilviaBordiga has achieved an international reputation. She is also involved in a the COLLABORATIVE projectFLYHY (VII Framework programs) devoted to the development of new materials for hydrogen storage and ina project in the platform Fuel Cells and Hydrogen Joint Undertaking (FCH JU) entitled Fuel Cell Coupled SolidState Hydrogen Storage Tank (SSH2S). She has authored (or co-authored) 250 papers listed in the ISI database, that have received more than 10000 citations from 3485 articles (fraction of self-citing articles 6.5%).The average citations for published articles is higher than 37 and the h-index is 58. Among published papers5 have received more than 200 citations, and 16 more than 100. She is member of the scientific committeeof the centre of excellence NIS at Torino University. She is actively involved in both fundamental andapplicative collaborations on subjects asked by different industries such as BASF, Saes Getters, ENI,CRF-FIAT and Topsøe. She has several international collaborations with universities and research labs(Oslo, Lyon, St. Andrews, Berkeley, Praha and Trondheim, are the most relevant). She is member ofConsiglio Direttivo of INSTM (Consortium Interuniversitario per la scienza e tecnologia dei materiali). Shehas organized all the three editions of NANOCAT school, an international school on catalysis (Torino (I)14-20 September 2003; Lyon (F) 23-28 October 2005 and Trondheim (No) 21-25 June 2009). She waschairwoman of the section “New experimental approaches and characterization under reaction conditions(combinatorial methods included) at EUROPACAT VIII international conference in 2007 (26-31 August inTurku, Finland). In 2007 and 2008 she has been invited by the University of Ghent to be member of theInternational panel for the ranking of Matusalem programs submitted by Ghent’s top scientists in alldisciplines. She was member of the Scientific committee of the International conference ABC (Acid and


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Base Catalysis), Genova 10-14 of May 2009 and Member of the Scientific commettee of MOFCATWorkshop 2009 “MOFs on the Road to Applications”, 17-19 June, 2009, at the Oslo Innovation Center inOslo, Norway.2011 invited key notes lectures: 5th Euchems Conference on Nitrogen Ligands- September 4-8 Granada(Spain) and ISHHC Berlin September 11-18 (Germany). 2010 invited lectures: MIT Boston (USA) August 27“Comparative Use of in-Situ Spectroscopic Methods for the Characterization of Active Sites in PorousMaterials” Berkeley (USA) 3rd September, Combined use of "in situ" spectroscopies and computationaltechniques to characterize molecularly defined species. 2009 Cairo (Egypt) February 23 “Molecular storageof hydrogen” Nanocat-InGAP school Trondheim (Norway) June 23 Reactivity of Cr(II) sites in heterogeneouscatalysts

9.1 Tenured professors

nº Surname Name Department Title Time spent for the

project (Hours/year)

Age

1. BATTEZZATI

Livio

CHIMICA I.F.M.

Fullprofessor

100

60

2. BORDIGA

Silvia

CHIMICA I.F.M.

Associateprofessor

200

46

3. CARBONE

Emilio

NEUROSCIENZE

Fullprofessor

100

63

4. CHIEROTTI

MicheleRemo

CHIMICA I.F.M.

Assistantprofessor

200

34

5. DOVESI

Roberto

CHIMICA I.F.M.

Fullprofessor

100

63

6. GIUSTETTO

Roberto

SCIENZEMINERALOGICHE EPETROLOGICHE

Assistantprofessor

200

45

7. LAMBERTI

Carlo

CHIMICA I.F.M.

Associateprofessor

100

46

8. LOVISOLO

Davide

BIOLOGIA ANIMALE EDELL'UOMO

Fullprofessor

100

64

9. MARTRA

Gianmario

CHIMICA I.F.M.

Associateprofessor

100

44


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10. MORTERRA

Claudio

CHIMICA I.F.M.

Fullprofessor

20

70

11. MUNARON

Luca Maria


Associateprofessor

100

44

12. OPERTI

Lorenza

CHIMICA GENERALE ECHIMICA ORGANICA

Fullprofessor

100

54

13. PAGANINI

MariaCristina

CHIMICA I.F.M.

Assistantprofessor

200

41

14. QUAGLIOTTO

Pierluigi

CHIMICA GENERALE ECHIMICA ORGANICA

Assistantprofessor

200

47

15. RICCHIARDI

Gabriele

CHIMICA I.F.M.

Assistantprofessor

100

44

16. SADEGHI

Jila


Assistantprofessor

200

42

17. SCARANO

Domenica

CHIMICA I.F.M.

Associateprofessor

100

54

18. TRUCCATO

Marco

FISICA SPERIMENTALE

Assistantprofessor

200

45

19. UGLIENGO

Piero

CHIMICA I.F.M.

Associateprofessor

100

53

20. VITTONE

Ettore

FISICA SPERIMENTALE

Associateprofessor

100

51

21. ZANETTI

Marco

CHIMICA I.F.M.

Assistantprofessor

200

42

9.2 Research fellows


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nº Surname Name Department Title Time spent for the

project

(Hours/year)

Age

1. AGOSTINI

Giovanni

Centro Interdipartimentale "Centro diEccellenza Superficie ed InterfasiNanostrutturate- NIS"

Assegnista

100

31

2. AINA

Valentina


Assegnista

400

32

3. FIORE

Gianluca


Assegnista

400

31

4. VITILLO

JennyGrazia


Assegnista

100

32

9.3 PhD students

nº Surname Name Department Title Time spent for

the project

(Hours/year)

Age

1. BARZAN

Caterina

Centro Interdipartimentale"Centro di EccellenzaSuperficie ed InterfasiNanostrutturate- NIS"

Dottorando

400

24

2. CALORIO

Chiara


Dottorando

300

27

3. CATUCCI

Gianluca


Dottorando

400

27

4. CULTRERA

Alessandro


Dottorando

500

29


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5. DALLAFONTANA

Giulia


Dottorando

400

25

6. GAGLIOTI

Katia


Dottorando

400

25

7. GATTOMONTICONE

Daniele


Dottorando

500

24

8. GAVELLO

Daniela


Dottorando

300

27

9. GENOVA

Tullio


Dottorando

400

24

10. GIONCO

Chiara


Dottorando

300

24

11. GOSSO

Sara


Dottorando

300

32

12. HAZNEDAR

Galip


Dottorando

500

30

13. RUFFINATTI

FedericoAlessandro


Dottorando

400

28


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9.4 Technical staff

nº Surname Name Department Title Time spent for

the project

(Hours/year)

Age

1. AGOSTINO

Angelo


PosizioneeconomicaD4

300

39

2. ANTONIOTTI

Susanna


PosizioneeconomicaEP2

300

45

3. BONINO

FrancescaCarla



300

35

4. CESANO

Federico



100

37

5. DAMIN

Alessandro


PosizioneeconomicaEP1

300

40

6. FRANCHINO

Claudio


PosizioneeconomicaC3

300

41

7. GILARDINO

Alessandra



300

40

8. MANZOLI

Maela



300

40


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9. TURCI

Francesco



300

34

9.5 Post doctoral fellows to be hired for project

nº Description Total

cost

Duration

(months)

1. Synthesis and properties of amorphous/nanocrystalline alloys

25000

12

2. Nanostructured interfaces in high-temperature superconducting oxides

25000

12

3. Structural and functional characterization of carbon-based materials anddevices

25000

12

4. Investigation at ab-initio level of graphitic products

25000

12

5. Electron transport in defective oxide semiconductors

25000

12

6. Synthesis and characterization of carbon - polymer nanocomposites

25000

12

7. Combined studies to develop hybrid materials for adsorption

37500

18

8. In situ characterization of active sites in catalysis and adsorption

37500

18

9. Synthesis and characterization of functional nanocomposites

37500

18

10. Advances in XRPD and Electron microscopy applied to nanosctructuredmaterials

37500

18

11. Modeling of biomaterials and their interaction

25000

12

12. Preparation and charactrization of metal-nano particles of biomedicalinterest

25000

12


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13. Preparation and characterization of biomimetic ceramics

25000

12

14. Measurements of neuronal and chromaffin cells electrical activitity usingMEAs

25000

12

15. Physical chemical investigations of surface properties of bio materialsrelated to their potential adverse biological response

25000

12

16. Mutagenesis and fluorescent labelling of P450 variants for immobilization

25000

12

TOTAL 450000

9.6 Investigators from other Italian Universities

Surname Name University Department Title Time spent for the project (Hours/year) Age

9.7 Investigators from foreign Universities

nº Surname Name University Title Time spent for the project (Hours/year) Age

9.8 Investigators from Italian research institutions

nº Surname Name Institution Title Time spent for the project

(Hours/year)

Age

1. Adriano

Zecchina

Accademia deiLincei

Prof.Emerito

300

74

10 Project team UniTO publications

1. VALENTINA AINA, FRANCESCA BONINO, MORTERRA C., MARTA MIOLA, CLAUDIA L. BIANCHI,GIANLUCA MALAVASI, MARCO MARCHETTI, VERA BOLIS. (2011). Influence of the chemicalcomposition on nature and activity of the surface layer of Zn-substituted sol-gel (bioactive) glasses.JOURNAL OF PHYSICAL CHEMISTRY. C, NANOMATERIALS AND INTERFACES. vol. 115, pp.2196-2210 ISSN: 1932-7447. doi:10.1021/jp1101708.

2. G. LUSVARDI, G. MALAVASI, V. AINA, L. BERTINETTI, G. CERRATO, G. MAGNACCA, MORTERRA C.,

L. MENABUE. (2010). Bioactive Glasses Containing Au Nanoparticles. Effect of CalcinationTemperature on Structure, Morphology, and Surface Properties. LANGMUIR. vol. 26(12), pp.10303-10314 ISSN: 0743-7463. doi:10.1021/la100472p.


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3. LOREDANA BERGANDI, VALENTINA AINA, STEFANO GARETTO, GIANLUCA MALAVASI,ELISABETTA ALDIERI, ENZO LAURENTI, LINA MATERA, MORTERRA C., DARIO GHIGO. (2010).Fluoride-containing bioactive glasses inhibit pentose phosphate oxidative pathway and glucose6-phosphate dehydrogenase activity in human osteoblasts. CHEMICO-BIOLOGICAL INTERACTIONS.vol. 183, pp. 405-415 ISSN: 0009-2797, PMID: 19945446 doi:10.1016/j.cbi.2009.11.021.

4. GIANLUCA MALAVASI, ERIKA FERRARI, GIGLIOLA LUSVARDI, VALENTINA AINA, FRANCESCA

FANTINI, MORTERRA C., FRANCESCA PIGNEDOLI, MONICA SALADINI, LEDI MENABUE. (2011).The role of coordination chemistry in the development of innovative gallium-based bioceramics: thecase of curcumin. JOURNAL OF MATERIALS CHEMISTRY. vol. 21, pp. 5027-5037 ISSN: 0959-9428.

5. ARIANO P, ZAMBURLIN P, GILARDINO A, MORTERA R, ONIDA B, TOMATIS M, GHIAZZA M, FUBINI

B, LOVISOLO D. (2011). On the interaction of spherical silica nanoparticles with neuronal cells:size-dependent toxicity and perturbation of calcium homeostasis. SMALL. vol. 7, pp. 766-774 ISSN:1613-6810.

6. I. MILETTO, A. GILARDINO, P. ZAMBURLIN, S.DALMAZZO, LOVISOLO D., G. CAPUTO, G. VISCARDI,

G. MARTRA. (2010). Highly bright and photostable cyanine dye-doped silica nanoparticles for opticalimaging: photophysical characterization and cell tests. DYES AND PIGMENTS. vol. 84, pp. 121-127ISSN: 0143-7208.

7. P. ARIANO, P. ZAMBURLIN, R. D'ALESSANDRO, J. MELDOLESI, LOVISOLO D. (2010).

DIFFERENTIAL REPRESSION BY THE TRANSCRIPTION FACTOR REST/NRSF OF THE VARIOUSCa2+ SIGNALLING MECHANISMS IN PHEOCHROMOCYTOMA PC12 CELLS. CELL CALCIUM. vol.47, pp. 360-368 ISSN: 0143-4160. doi:10.1016/j.ceca.2010.01.007.

8. ARIANO P, BUDNYK O, DALMAZZO S, LOVISOLO D., MANFREDOTTI C, RIVOLO P, STEINMű,

LLER-NETHL D, VITTONE E. (2009). On diamond surface properties and interactions with neurons.THE EUROPEAN PHYSICAL JOURNAL. E, SOFT MATTER. vol. 30, pp. 149-156 ISSN: 1292-8941.

9. DEGREGORIO D., SADEGHI S. J., DI NARDO G., GILARDI G., SOLINAS S.P. (2011). Understanding

uncoupling in the multi-redox centre P450 3A4-BMR model system. JBIC. vol. 16, pp. 109-116 ISSN:0949-8257. doi:10.1007/s00775-010-0708-0.

10. SADEGHI S. J., FANTUZZI A., GILARDI G. (2011). Breakthrough in P450 bioelectrochemistry and future

perspectives. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. vol. 1814, pp. 237-248 ISSN:0005-2728. doi:10.1016/j.bbapap.2010.07.010.

11. MAK L.H., SADEGHI S. J., FANTUZZI A., GILARDI G. (2010). Control of Human Cytochrome P450 2E1

Electrocatalytic Response as a Result of Unique Orientation on Gold Electrodes. ANALYTICALCHEMISTRY. vol. 82, pp. 458-459 ISSN: 0003-2700.

12. SADEGHI S. J., RITA MEIRINHOS, GIANLUCA CATUCCI, VIKASH DODHIA, GIOVANNA DI NARDO,

GIANFRANCO GILARDI. (2010). Direct Electrochemistry of Drug Metabolizing Human Flavin-ContainingMonooxygenase: Electrochemical Turnover of Benzydamine and Tamoxifen. JOURNAL OF THEAMERICAN CHEMICAL SOCIETY. vol. 132, pp. 458-459 ISSN: 0002-7863.

13. PAOLA ANTONIOTTI, ELENA BOTTIZZO, OPERTI L., ROBERTO RABEZZANA, STEFANO BOROCCI,

FELICE GRANDINETTI. (2010). F3Ge-Xe+: a Xenon-Germanium Molecular Species. THE JOURNALOF PHYSICAL CHEMISTRY LETTERS. vol. 1, pp. 2006-2010 ISSN: 1948-7185.


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doi:10.1021/jz100676g.

14. P. ANTONIOTTI, OPERTI L., R. RABEZZANA, F. TURCO, C. ZANZOTTERA, M. GIORDANI, F.

GRANDINETTI. (2009). Gas-phase reactions of XH3+ (X = C, Si, Ge) with NF3: a comparativeinvestigation on the detailed mechanistic aspects. JOURNAL OF MASS SPECTROMETRY. vol. 44, pp.1348-1358 ISSN: 1076-5174. doi:10.1002/jms.1617.

15. OPERTI L., R. RABEZZANA, F. TURCO, G.A. VAGLIO. (2007). Gas-phase positive and negative

ion/molecule reactions in diborane and silane/diborane mixtures. INTERNATIONAL JOURNAL OF MASSSPECTROMETRY. vol. 264, pp. 61-69 ISSN: 1387-3806. doi:10.1016/j.ijms.2007.03.018.

16. OPERTI L., R. RABEZZANA. (2006). Gas-phase ion chemistry in organometallic systems. MASS

SPECTROMETRY REVIEWS. vol. 25, pp. 483-513 ISSN: 0277-7037. doi:10.1002/mas.20075.

17. RAFFAELLA DEMICHELIS, YVES NOEL, PHILIPPE D’, ARCO, LORENZO MASCHIO, ROBERTO

ORLANDO, DOVESI R. (2010). Structure and energetics of imogolite: a quantum mechanical ab initiostudy with B3LYP hybrid functional. JOURNAL OF MATERIALS CHEMISTRY. vol. 20, pp. 10417-10425ISSN: 0959-9428. doi:10.1039/c0jm00771d.

18. Y. NOEL, PH. D'ARCO, R. DEMICHELIS, C.M. ZICOVICH-WILSON, DOVESI R. (2010). On the use of

symmetry in the ab initio quantum mechanical simulation of nanotubes and related materials. JOURNALOF COMPUTATIONAL CHEMISTRY. vol. 31, pp. 855-862 ISSN: 0192-8651.

19. P. D’, ARCO, Y. NOEL, R. DEMICHELIS, DOVESI R. (2009). Single-layered chrysotile nanotubes: A

quantum mechanical ab initio simulation. THE JOURNAL OF CHEMICAL PHYSICS. vol. 131, pp.204701-- ISSN: 0021-9606.

20. Y. NOEL, R. DEMICHELIS, F. PASCALE, P. UGLIENGO, R. ORLANDO, DOVESI R. (2009). Ab initio

quantum mechanical study of gamma-AlOOH boehimite: structure and vibrational spectrum. PHYSICSAND CHEMISTRY OF MINERALS. vol. 36, pp. 47-59 ISSN: 0342-1791.doi:10.1007/s00269-008-0257-z.

21. MARCANTONI A, VANDAEL DH, MAHAPATRA S, CARABELLI V, SINNEGGER-BRAUNS MJ,

STRIESSNIG J, CARBONE E. (2010). Loss of Cav1.3 channels reveals the critical role of L- andBK-channel coupling in pace-making mouse adrenal chromaffin cells. THE JOURNAL OFNEUROSCIENCE. vol. 30(2), pp. 491-504 ISSN: 0270-6474, PMID: 20071512 (J NEUROSCI)doi:10.1523/JNEUROSCI.4961-09-2010.

22. Z. GAO, V. CARABELLI, CARBONE E., E. COLOMBO, F. DEMARIA, M. DIPALO, S. GOSSO, CH.

MANFREDOTTI, A. PASQUARELLI, S. ROSSI, Y. XU, E. VITTONE, E. KOHN. (2010). TransparentDiamond Microelectrodes for Biochemical Application. DIAMOND AND RELATED MATERIALS. vol. 19,pp. 1021-1026 ISSN: 0925-9635. doi:10.1016/j.diamond.2010.03.014.

23. PAOLO ARIANO, ALESSANDRO LO GIUDICE, ANDREA MARCANTONI, ETTORE VITTONE,

CARBONE E., DAVIDE LOVISOLO. (2009). A diamond-based biosensor for the recording of neuronalactivity. BIOSENSORS & BIOELECTRONICS. vol. 24, pp. 2046-2050 ISSN: 0956-5663, PMID:19062266 (BIOSENS BIOELECTRON) doi:10.1016/j.bios.2008.10.017.


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24. V. CARABELLI, MARCANTONI A, COMUNANZA V, DE LUCA A, DÍAZ J, BORGES R, CARBONE E.(2007). Chronic hypoxia up-regulates alpha1H T-type channels and low-threshold catecholaminesecretion in rat chromaffin cells. THE JOURNAL OF PHYSIOLOGY. vol. 584.1, pp. 149-165 ISSN:0022-3751.

25. J. SINGH, LAMBERTI C., J. A. VAN BOKHOVEN. (2010). Advanced X-ray absorption and emission

spectroscopy: in situ catalytic studies. CHEMICAL SOCIETY REVIEWS. vol. 39, pp. 4754-4766 ISSN:0306-0012. doi:10.1039/c0cs00054j Rivista di rassegna su invito.

26. S. BORDIGA, F. BONINO, K. L. LILLERUD, LAMBERTI C. (2010). X-ray absorption spectroscopies:

useful tools to understand Metallorganic frameworks structure and reactivity. CHEMICAL SOCIETYREVIEWS. vol. 39, pp. 4885-4927 ISSN: 0306-0012. doi:10.1039/C0CS00082E Invited Critical Reviewas part of theIn-situ characterization of heterogeneous catalystshemed issue.

27. J. A.VAN BOKHOVEN, T. L. LEE, M. DRAKOPOULOS, LAMBERTI C., S. THISS, J. ZEGENHAGEN.

(2008). Determining the aluminium occupancy on the active T-sites in zeolites using X-ray standingwaves. NATURE MATERIALS. vol. 7, pp. 551-555 ISSN: 1476-1122. doi:10.1038/nmat2220 Letter.

28. J. H. CAVKA, S. JAKOBSEN, U. OLSBYE, N. GUILLOU, LAMBERTI C., S. BORDIGA, K. L. LILLERUD.

(2008). A new zirconium inorganic building brick forming metal organic frameworks with exceptionalstability. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. vol. 130, pp. 13850-13851 ISSN:0002-7863. doi:10.1021/ja8057953 Communication to the Editor.

29. ALESSANDRA FIORIO PLA, TULLIO GENOVA, EMANUELA PUPO, CRISTIANA TOMATIS, ARMANDO

GENAZZANI, ROBERTA ZANINETTI, MUNARON L. (2010). MULTIPLE ROLES OF PROTEIN KINASE AON ARACHIDONIC ACID-MEDIATED CA2+ ENTRY AND TUMOR-DERIVED HUMAN ENDOTHELIALCELLS MIGRATION. MOLECULAR CANCER RESEARCH. vol. 8, pp. 1466-1476 ISSN: 1541-7786.

30. SUSANNA ANTONIOTTI, PAOLO FATTORI, CRISTIANA TOMATIS, ENRICA PESSIONE, MUNARON L.

(2009). Arachidonic acid and calcium signals in human breast tumor-derived endothelial cells: aproteomic study. JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH. vol. 29, pp.257-265 ISSN: 1079-9893.

31. A. FIORIO PLA, C. GRANGE, S. ANTONIOTTI, C. TOMATIS, A. MERLINO, B. BUSSOLATI, MUNARON

L. (2008). Arachidonic acid-induced Ca2+ entry is involved in earlysteps of tumor angiogenesis.MOLECULAR CANCER RESEARCH. vol. 6 (4), pp. 535-545 ISSN: 1541-7786.doi:10.1158/1541-7786.MCR-07-0271.

32. TOMATIS C, FIORIO PLA A, MUNARON L. (2007). Cytosolic calcium microdomains by arachidonic acid

and nitric oxide in endothelial cells. CELL CALCIUM. vol. 41(3), pp. 261-269 ISSN: 0143-4160.doi:10.1016/j.ceca.2006.07.003 published online.

33. L. VALENZANO, B. CIVALLERI, S. CHAVAN, BORDIGA S., M. H. NILSEN, S. JAKOBSEN, K.-P.

LILLERUD, C. LAMBERTI. (2011). Disclosing the complex structure of UiO-66 Metal OrganicFramework: a synergic combination of experiment and theory. CHEMISTRY OF MATERIALS. vol. 23,pp. 1700-1718 ISSN: 0897-4756. doi:10.1021/cm1022882.


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34. C. LAMBERTI, A. ZECCHINA, E. GROPPO, BORDIGA S. (2010). Probing the surfaces ofheterogeneous catalysts by in situ IR spectroscopy. CHEMICAL SOCIETY REVIEWS. vol. 39, pp.4951-5001 ISSN: 0306-0012. doi:10.1039/c0cs00117a Articolo di rassegna su invito.

35. L.J. MURRAY, M. DINCA, J. YANO, S. CHAVAN, BORDIGA S., C.M. BROWN, J.R. LONG. (2010).

Highly-Selective and Reversible O-2 Binding in Cr-3(1,3,5-benzenetricarboxylate)(2). JOURNAL OF THEAMERICAN CHEMICAL SOCIETY. vol. 132, pp. 7856-7857 ISSN: 0002-7863. doi:10.1021/ja1027925Communication.

36. N. MASCIOCCHI, S. GALLI, V. COLOMBO, A. MASPERO, G. PALMISANO, B. SEYYEDI, C.

LAMBERTI, BORDIGA S. (2010). Cubic Octanuclear Ni(II) Clusters in Highly PorousPolypyrazolyl-Based Materials. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. vol. 132, pp.7902-7904 ISSN: 0002-7863. doi:10.1021/ja102862j Communication to the Editor.

37. M. RIVALLAN, G. RICCHIARDI, BORDIGA S., A. ZECCHINA. (2009). reactivity of nitrogen oxides (NO2,

NO, N2O) on Fe-zeolites. JOURNAL OF CATALYSIS. vol. 264, pp. 104-116 ISSN: 0021-9517.doi:10.1016/j.jcat.2009.03.012.

38. E. GROPPO, M. J. UDDIN, BORDIGA S., A. ZECCHINA, C. LAMBERTI. (2008). Structure and red-ox

activity of Cu sites isolated in a nanoporous P4VP polymeric matrix. ANGEWANDTE CHEMIE.INTERNATIONAL EDITION. vol. 47, pp. 9269-9273 ISSN: 1433-7851. doi:10.1002/anie.200802815.

39. YURIY SAKHNO, LUCA BERTINETTI, MICHELE IAFISCO, NORBERTO ROVERI, ANNA TAMPIERI,

MARTRA G. (2010). Surface Hydration and Cationic Sites of Nanohydroxyapatites with Amorphous orCrystalline Surfaces: A Comparative Study. JOURNAL OF PHYSICAL CHEMISTRY. C,NANOMATERIALS AND INTERFACES. vol. 114, pp. 16640-16648 ISSN: 1932-7447.doi:10.1021/jp105971s.

40. B. PALAZZO, D. WALSH, M. IAFISCO, E. FORESTI, L. BERTINETTI, MARTRA G., C.L. BIANCHI, G.

CAPPELLETTI, N. ROVERI. (2009). Aminoacid synergetic effect on structure, morphology and surfaceproperties of biomimetic apatite nanocrystals. ACTA BIOMATERIALIA. vol. 5, pp. 1241-1252 ISSN:1742-7061. doi:10.1016/j.actbio.2008.10.024.

41. L. BERTINETTI, C. DROUET, C. COMBES, C. REY, A. TAMPIERI, S. COLUCCIA, MARTRA G. (2009).

Surface characteristics of nanocrystalline apatites: effect of Mg surface enrichment on morphology,surface hydration species and cationic environments. LANGMUIR. vol. 25, pp. 5647-5654 ISSN:0743-7463. doi:10.1021/la804230j.

42. BERTINETTI L, TAMPIERI A, LANDI E, DUCATI C, COLUCCIA S, MARTRA G. (2007). Surface

structure, hydration and cationic sites of nanohydroxyapatite: UHR-TEM, IR and microgravimetricstudies. JOURNAL OF PHYSICAL CHEMISTRY. C, NANOMATERIALS AND INTERFACES. vol. 111, pp.4027-4035 ISSN: 1932-7447.

43. BATTEZZATI L. (2010). Thermodynamic, transport and mechanical properties of amorphous metallic

alloys: relation to the glass transition. JOURNAL OF ALLOYS AND COMPOUNDS. vol. 495, pp.294-298 ISSN: 0925-8388.

44. FEDERICO SCAGLIONE, ANNETT GEBERT, BATTEZZATI L. (2010). Dealloying of an Au-based

amorphous alloy. INTERMETALLICS. vol. 18, pp. 2338-2342 ISSN: 0966-9795.


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45. G. FIORE, I. ICHIM, BATTEZZATI L. (2010). Thermal analysis, fragility and viscosity of Au-based

metallic glasses. JOURNAL OF NON-CRYSTALLINE SOLIDS. vol. 356, pp. 2218-2222 ISSN:0022-3093. doi:10.1016/j.jnoncrysol.2010.08.032.

46. M. PALUMBO, BATTEZZATI L. (2008). Thermodynamics and kinetics of metallic amorphous phases in

the framework of the CALPHAD approach. CALPHAD. vol. 32, pp. 295-314 ISSN: 0364-5916.

47. CZOSKA A.M., LIVRAGHI S., PAGANINI M.C., GIAMELLO E., DI VALENTIN C., PACCHIONI G. (2011).

The nitrogen-boron paramagnetic center in visible light sensitized N-B co-doped TiO2. Experimental andtheoretical characterization. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. vol. 13, pp. 136-143 ISSN:1463-9076.

48. LIVRAGHI S., OLIVERO F., PAGANINI M.C., GIAMELLO E. (2010). Titanium ions dispersed into the

ZrO2 matrix: Spectroscopic properties and photoinduced electron transfer. JOURNAL OF PHYSICALCHEMISTRY. C, NANOMATERIALS AND INTERFACES. vol. 114, pp. 18553-18558 ISSN: 1932-7447.

49. S. MORANDI, PAGANINI M.C., E. GIAMELLO, M. BINI, D. CAPSONI, V. MASSAROTTI, G. GHIOTTI.

(2009). Structural and spectroscopic characterization of Mo(1-x)WxO(3-d) mixed oxides. JOURNAL OFSOLID STATE CHEMISTRY. vol. 182, pp. 3342-3352 ISSN: 0022-4596.

50. LIVRAGHI S, PAGANINI M.C., GIAMELLO E, SELLONI A, DI VALENTIN C, PACCHIONI G. (2006).

Origin of photoactivity of nitrogen-doped titanium dioxide under visible light. JOURNAL OF THEAMERICAN CHEMICAL SOCIETY. vol. 128 (49), pp. 15666-15671 ISSN: 0002-7863.

51. CHIEROTTI M.R., LUCA FERRERO, NADIA GARINO, ROBERTO GOBETTO, LUCA PELLEGRINO,

DARIO BRAGA, FABRIZIA GREPIONI, LUCIA MAINI. (2010). The Richest Collection of TautomericPolymorphs: The Case of 2-Thiobarbituric Acid. CHEMISTRY-A EUROPEAN JOURNAL. vol. 16, pp.4347-4358 ISSN: 0947-6539. doi:10.1002/chem.200902485.

52. JESSE ALLEN, EDWARD ROSENBERG, CHIEROTTI M.R., ROBERTO GOBETTO. (2010). Surface

oxidation of Co2+ and its dependence on ligand coordination number in silica polyamine composites.INORGANICA CHIMICA ACTA. vol. 363, pp. 617-624 ISSN: 0020-1693.

53. GOBETTO ROBERTO, CHIEROTTI M.R. (2008). Solid-state NMR studies of weak interactions in

supramolecular systems. CHEMICAL COMMUNICATIONS. vol. 2008, pp. 1621-1634 ISSN: 1359-7345.

54. LIVRAGHI S, CHIEROTTI M.R., GIAMELLO E, MAGNACCA G, PAGANINI C, CAPPELLETTI G,

BIANCHI CL. (2008). Nitrogen-Doped Titanium Dioxide Active in Photocatalytic Reactions with VisibleLight: A Multi-Technique Characterization of Differently Prepared Materials. JOURNAL OF PHYSICALCHEMISTRY. C, NANOMATERIALS AND INTERFACES. vol. 112, pp. 17244-17252 ISSN: 1932-7447.

55. QUAGLIOTTO P., BARBERO N, BAROLO C, ARTUSO E, COMPARI C, FISICARO E, VISCARDI G.

(2009). Synthesis and properties of cationic surfactants with tuned hydrophylicity. JOURNAL OFCOLLOID AND INTERFACE SCIENCE. vol. 340, pp. 269-275 ISSN: 0021-9797.doi:10.1016/j.jcis.2009.09.009.


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56. QUAGLIOTTO P., BAROLO C, BARBERO N, BARNI E, COMPARI C, FISICARO E, VISCARDI G.(2009). Synthesis and Characterization of Highly Fluorinated Gemini Pyridinium Surfactants.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. vol. -, pp. 3167-3177 ISSN: 1434-193X.doi:10.1002/ejoc.200900063.

57. E. MONTONERI, G. VISCARDI, S. BOTTIGLIENGO, R. GOBETTO, M. R. CHIEROTTI, R. BUSCAINO,

QUAGLIOTTO P. (2007). 4-Sulphophenylphosphonic acid: a novel precursor to fabbricate polyfunctionalacid materials. CHEMISTRY OF MATERIALS. vol. 19(10), pp. 2671-2678 ISSN: 0897-4756.doi:10.1021/cm063071r.

58. C. BAROLO, M.K. NAZEERUDDIN, S. FANTACCI, D. DI CENSO, P. COMTE, P. LISKA, G. VISCARDI,

QUAGLIOTTO P., F. DE ANGELIS, S. ITO, M GRÄTZEL. (2006). Synthesis, characterization, andDFT-TDDFT computational study of a ruthenium complex containing a functionalized tetradentate ligand.INORGANIC CHEMISTRY. vol. 45, pp. 4642-4653 ISSN: 0020-1669. doi:10.1021/ic051970w.

59. BARUS S., ZANETTI M., BRACCO P., MUSSO S., CHIODONI A., TAGLIAFERRO A. (2010). Influence

of MWCNT morphology on dispersion and thermal properties of polyethylene nanocomposites.POLYMER DEGRADATION AND STABILITY. vol. 95, pp. 756-762 ISSN: 0141-3910.doi:10.1016/j.polymdegradstab.2010.02.013.

60. S. BARUS, ZANETTI M., M. LAZZARI, L. COSTA. (2009). Preparation of hybrid polymeric

nanocomposites based upon PE and silica. POLYMER. vol. 50, pp. 2595-2600 ISSN: 0032-3861.

61. S. GESTÍA, ZANETTI M., M. LAZZARI, L. FRANCO, J. PUIGGALÍ. (2009). egradable polyoctamethylene

suberate/clay nanocomposites. Crystallization studies by DSC and simultaneous SAXS/WAXDsynchrotron radiation. EUROPEAN POLYMER JOURNAL. vol. 45, pp. 398-409 ISSN: 0014-3057.doi:10.1016/j.eurpolymj.2008.10.037.

62. SIMONE MUSSO, ZANETTI M., ALBERTO TAGLIAFERRO, MARIA PAOLA LUDA. (2007). B2.

Domanda di brevetto industriale n°. TO2007A000923 "Procedimento di riciclo di materiali plastici discarto con produzione di nanotubi di carbonio" domanda depositata il 20.12.2007. n°. TO2007A000923.Università di TorinoPolitecnico di Torino. (pp. -).

63. GHEORGHE ALDICA, STEFANO CAGLIERO, ANGELO AGOSTINO, CARLO LAMBERTI, TRUCCATO

M. (2011). 17 keV-photon induced damage of Bi-2212 whiskers by synchrotron µ-beam exposure.SUPERCONDUCTOR SCIENCE & TECHNOLOGY. vol. 24, pp. 035009-- ISSN: 0953-2048.doi:10.1088/0953-2048/24/3/035009.

64. M. DE LA PIERRE, S. CAGLIERO, A. AGOSTINO, G.C. GAZZADI, TRUCCATO M. (2009).

Size-dependent resistivity in a micro-processed YBa2Cu3O7-delta superconducting whisker.SUPERCONDUCTOR SCIENCE & TECHNOLOGY. vol. 22, pp. 045011-- ISSN: 0953-2048.doi:10.1088/0953-2048/22/4/045011.

65. M. M. R. KHAN, S. CAGLIERO, A .AGOSTINO, M. BEAGUM, C. PLAPCIANU, TRUCCATO M. (2009).

Control of the oxygen doping in Bi-2212 whiskers by means of their synthesis process.SUPERCONDUCTOR SCIENCE & TECHNOLOGY. vol. 22, pp. 085011-- ISSN: 0953-2048.doi:10.1088/0953-2048/22/8/085011.


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66. S. CAGLIERO, A. PIOVANO, C. LAMBERTI, M. M. RAHMAN KHAN, A. AGOSTINO, G. AGOSTINI, D.GIANOLIO, L. MINO, J. A. SANS, CH. MANFREDOTTI, TRUCCATO M. (2009). Synchrotron study ofoxygen depletion in a Bi-2212 whisker annealed at 363 K. JOURNAL OF SYNCHROTRON RADIATION.vol. 16, pp. 813-817 ISSN: 0909-0495. doi:10.1107/S0909049509036802.

67. FEDERICO CESANO, SERENA BERTARIONE, SCARANO D., GIUSEPPE SPOTO, ADRIANO

ZECCHINA. (2009). Designing of carbon nanofilaments-based composites for innovative applications.DIAMOND AND RELATED MATERIALS. vol. 18, pp. 979-983 ISSN: 0925-9635.doi:10.1016/j.diamond.2008.11.011.

68. F. CESANO, S. BERTARIONE, A. DAMIN, G. AGOSTINI, S. USSEGLIO, J. G. VITILLO, C. LAMBERTI,

G. SPOTO, SCARANO D., A. ZECCHINA. (2008). Oriented TiO2 nanostructured pillar arrays: Synthesisand characterization. ADVANCED MATERIALS. vol. 20, pp. 3342-3348 ISSN: 0935-9648.doi:10.1002/adma.200702768 Communication.

69. F. CESANO, SCARANO D., S. BERTARIONE, F. BONINO, A. DAMIN, S. BORDIGA, C. PRESTIPINO,

C. LAMBERTI, A. ZECCHINA. (2008). Synthesis of ZnO–carbon composites and imprinted carbon bythe pyrolysis of ZnCl2-catalyzed furfuryl alcohol polymers. JOURNAL OF PHOTOCHEMISTRY ANDPHOTOBIOLOGY. A, CHEMISTRY. vol. 196, pp. 143-153 ISSN: 1010-6030.doi:10.1016/j.jphotochem.2007.07.033.

70. LUCA MEZZO, ANDREA GAIO, FEDERICO CESANO, SCARANO D., ADRIANO ZECCHINA. (2006).

Synthesis of carbon nanotubes and/or nanofibres on a polymer substrate. WO/2007/043007. FIBRE ETESSUTI SPECIALI S.P.A. (pp. -).

71. GIUSTETTO R., O WAHYUDI, I CORAZZARI, F TURCI. (2011). Chemical stability and dehydration

behavior of a sepiolite/indigo Maya Blue pigment. APPLIED CLAY SCIENCE. vol. 52, pp. 41-50 ISSN:0169-1317. doi:10.1016/j.clay.2011.01.027.

72. GIUSTETTO R., O WAHYUDI. (2010). Synthesis and stability of red/purple Mayan nanocomposites.

MICROPOROUS AND MESOPOROUS MATERIALS. vol. 142, pp. 221-235 ISSN: 1387-1811.doi:10.1016/j.micromeso.2010.12.004.

73. CHIARI G, GIUSTETTO R., DRUZIK J, DOHENE E, RICCHIARDI G. (2008). Pre-columbian

nanotechnology:reconciling the mysteries of the Maya Blue pigment. APPLIED PHYSICS. A,MATERIALS SCIENCE & PROCESSING. vol. 90, pp. 3-7 ISSN: 0947-8396.

74. GIUSTETTO R., LEVY D, CHIARI G. (2006). Crystal structure refinement of Maya Blue pigment

prepared with deuterated indigo, using neutron powder diffraction. EUROPEAN JOURNAL OFMINERALOGY. vol. 18, pp. 629-640 ISSN: 0935-1221.

75. P. OLIVERO, G. AMATO, F. BELLOTTI, S. BORINI, A. L. GIUDICE, F. PICOLLO, VITTONE E. (2010).

Direct fabrication and IV characterization of sub-surface conductive channels in diamond with MeV ionimplantation. THE EUROPEAN PHYSICAL JOURNAL. B, CONDENSED MATTER PHYSICS. vol. 75, pp.127-132 ISSN: 1434-6028, ISI:000278473300003 doi:10.1140/epjb/e2009-00427-5 In the presentwork we report about the investigation of the conduction mechanism of sp(2) carbon micro-channels insingle crystal diamond. The str...


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76. PAOLO OLIVERO, SILVIA CALUSI, LORENZO GIUNTINI, STEFANO LAGOMARSINO, ALESSANDROLO GIUDICE, MIRKO MASSI, SILVIO SCIORTINOBEGIN_OF_THE_SKYPE_HIGHLIGHTING END_OF_THE_SKYPE_HIGHLIGHTINGBEGIN_OF_THE_SKYPE_HIGHLIGHTING END_OF_THE_SKYPE_HIGHLIGHTING, MAURIZIOVANNONI, VITTONE E. (2010). Controlled variation of the refractive index in ion-damaged diamond.DIAMOND AND RELATED MATERIALS. vol. 19, pp. 428-431 ISSN: 0925-9635.doi:10.1016/j.diamond.2009.12.011.

77. PICOLLO, OLIVERO, BELLOTTI, PASTUOVIC., SKUKAN, LO GIUDICE, AMATO, JAKSIC, VITTONE E.

(2010). Formation of buried conductive micro-channels in single crystal diamond with MeV C and Heimplantation. DIAMOND AND RELATED MATERIALS. vol. 19, pp. 466-469 ISSN: 0925-9635.doi:10.1016/j.diamond.2009.12.011.

78. P. OLIVERO, G. AMATO, F. BELLOTTI, O. BUDNYK, E. COLOMBO, M. JAKš, IC, C. MANFREDOTTI,

Ž, . PASTUOVIC, F. PICOLLO, N. SKUKAN, M. VANNONI, VITTONE E. (2009). Direct fabrication ofthree-dimensional buried conductive channels in single crystal diamond with ion microbeam inducedgraphitization. DIAMOND AND RELATED MATERIALS. vol. 18, pp. 870-876 ISSN: 0925-9635.doi:10.1016/j.diamond.2008.10.068.

79. M. CORNO, A. RIMOLA, V. BOLIS, UGLIENGO P. (2010). Hydroxyapatite as a key biomaterial:

quantum-mechanical simulation of its surfaces in interaction with bio-molecules. PHYSICALCHEMISTRY CHEMICAL PHYSICS. vol. 12, pp. 6309-6329 ISSN: 1463-9076. doi:10.1039/C002146F.

80. A. RIMOLA, B. CIVALLERI, UGLIENGO P. (2010). Physisorption of aromatic organic contaminants at

the surface of hydrophobic/hydrophilic silica geosorbents: a B3LYP-D modeling study. PHYSICALCHEMISTRY CHEMICAL PHYSICS. vol. 12, pp. 6357-6366 ISSN: 1463-9076. doi:10.1039/C000009D.

81. F. MUSSO, M. SODUPE, M. CORNO, UGLIENGO P. (2009). H-Bond Features of Fully Hydroxylated

Surfaces of Crystalline Silica Polymorphs: A Periodic B3LYP Study. JOURNAL OF PHYSICALCHEMISTRY. C, NANOMATERIALS AND INTERFACES. vol. 113, pp. 17876-17884 ISSN: 1932-7447.

82. A. RIMOLA, M. CORNO, C.M. ZICOVICH-WILSON, UGLIENGO P. (2009). Ab initio modeling of

protein/biomaterial interactions: competitive adsorption between glycine and water onto hydroxyapatitesurfaces. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. vol. 11, pp. 9005-9007 ISSN: 1463-9076.

83. M. RIVALLAN, RICCHIARDI G., S. BORDIGA, A. ZECCHINA. (2009). reactivity of nitrogen oxides (NO2,

NO, N2O) on Fe-zeolites. JOURNAL OF CATALYSIS. vol. 264, pp. 104-116 ISSN: 0021-9517.doi:10.1016/j.jcat.2009.03.012.

84. S. NEATU, V.I. PARVULESCU, G. EPURE, N. PETREA, V. SOMOGHI, RICCHIARDI G., S. BORDIGA,

A. ZECCHINA. (2009). M/TiO2/SiO2 (M = Fe, Mn, and V) catalysts in photo-decomposition of sulfurmustard. APPLIED CATALYSIS. B, ENVIRONMENTAL. vol. 91, pp. 546-553 ISSN: 0926-3373.doi:10.1016/j.apcatb.2009.06.026.

85. CHIARI G, GIUSTETTO R, DRUZIK J, DOHENE E, RICCHIARDI G. (2008). Pre-columbian

nanotechnology:reconciling the mysteries of the Maya Blue pigment. APPLIED PHYSICS. A,MATERIALS SCIENCE & PROCESSING. vol. 90, pp. 3-7 ISSN: 0947-8396.


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86. RICCHIARDI G., J. G. VITILLO, D. COCINA, E.N. GRIBOV, A. ZECCHINA. (2007). Direct observationand modelling of ordered hydrogen adsorption and catalyzed ortho–para conversion on ETS-10titanosilicate material. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. vol. 9, pp. 2753-2760 ISSN:1463-9076. doi:10.1039/b703409a.

10.1 Italian investigators' publications

10.2 Foreign investigators' publications

Surname Name Attachment PDF

11 Project background (rationale and preliminary findings)

Surfaces and interfaces are ubiquitous. They shape objects and give them their texture and structure. Atall scale levels and in objects as diverse as a piece of metal or a living cell, a close-up look at a material willreveal a fine structure made of boundaries and domains. The structure, chemical reactivity and physicalproperties of surfaces and interfaces largely determine the properties of materials. The deliberate designand fabrication of surfaces and interfaces at the atomic and nanometer scale, as well as of theirhomogeneous interface-free counterparts, has been a primary focus of nanotechnologies and nanosciencessince their beginning. A scan of the research achievements listed by the American NSF funded “NationalNanotechnology Initiative” for the period 2001-2009 (http://www.nano.gov/html/research/achievements.html)highlights the central role played by surface and interfaces both in “foundational research” and technology-oriented research. Recurring topics are for example: industrial catalysis by tailored porous materials,engineering of mechanical and magnetic properties of metal alloys by means of nano-scale control ofmicrostructure, high surface area carbon materials and their composites for chemical, electronic andmechanical applications, adhesion of biomolecules and cells to materials surfaces and the interaction ofliving cells with man-made nanoparticles. The common ground on which these projects rests is not only thenanometer size range but also the fact that they pursue the understanding and design of tiny functionalassemblies of matter, with a common set of theoretical and experimental tools like advanced microscopies,surface sensitive spectroscopic measurements, computational prediction of electronic properties and

intermolecular interactions, fabrication and characterization of nanometer-scale structures with techniques

like CVD, ion beams, rapid solidification, template synthesis, biological imaging techniques, single cell

signal recordings.

Indeed it is the appreciation of these common tools that has stimulated the creation of the “Centre ofExcellence on Nanostructure Interfaces” (NIS) of the University of Torino in 2001. This interdisciplinarycenter, directed by Prof. Adriano Zecchina gathers about 60 experienced researchers from the Chemistry,Physics, Biology and Neuroscience Departments of the Turin University, in a long-term effort to developinterdisciplinary projects on key topics in surface nanotechnologies and to build a common researchinfrastructure. The NIS Centre manages an open-access common laboratory at the “Centro dell’Innovazione”and supports several department laboratories. Through the participation to national, regional and Europeanresearch calls, it has approximately doubled the funding obtained by the ministry of education in 2003(starting grant) and by private mecenatism of the Compagnia di San Paolo(http://www.compagniadisanpaolo.it/) in the following years. Interdisciplinarity and achieving a critical massin fund raising have allowed the NIS Centre to set up state-of-the-art laboratories for surface and interfacestudies. Most relevant acquisitions are reported in the figure below.


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.NIS is also active in technology transfer to SMEs, with the scientific direction of a dedicated laboratory atthe Tecnoparco del Lago Maggiore (http://www.nanoireservice.it ) and specific project like the NANOMATproject of Regione Piemonte.While the scope of the NIS Centre is broad, the present application objectives are focused on selectedtopics which are believed to have breakthrough character and to be strategic in the development of futuretechnologies. The type of research proposed in the following chapters is at the same time fundamental andoriented to the development of novel technologies.


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The focus is on three main areas:1)Solid-solid interfaces: role of interfaces in advanced metals, particles boundary effects insuperconductors, conductors, semiconductors and insulatorsSolid-solid interfaces are the common feature of a group of related research activities at NIS because theproperties of solids (metals, ceramics, plastics, composites) stem from their microstructure and solid-solidinterfaces which in turn depends on chemical composition, synthesis method and any subsequent treatment.These activities form the backbone of research line 1 and they are related to the generation of patterns insolids:a) diamond/ graphite interfaces obtained by ion beam patterningb) layered semiconductor-insulator interfaces,c) photo-active semiconductors interfaces: role of synthesis and processing on microstructure and dopingd) porous metals by de-alloying: synthesis and surface propertiese) interface problems in polymer nanocomposites:These research topics have in common the characterization methodologies and the same technologicalscope (synthesis of suitable materials for solid-state devices for sensors and actuators). [1-7]2) Solid-gas and solid-liquid interactionsAs documented by the NIS publications in the 2003-2011 period , solid-gas and solid-liquid interactions formthe basis of a group of traditional research activities at NIS, like adsorption and catalysis, environmentalstudies, synthesis of novel encapsulation materials. In the framework of the present proposal, the followingrelated tasks will be pursued:a) role of surfaces in the capture of small molecules by hybrid materialsb) encapsulation of functional organic molecules in the cavities of inorganic solidsc) surface properties of supported noble metal particles as catalysts for fine chemicals and bio-fuels


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processesd) new zeolitic catalysts for key industrial processese) nanostructured photocatalysts with improved activity.Common ground of these tasks are the characterization techniques, comprising spectroscopic studies ofmolecule-surface interactions and advanced microscopies implemented by catalytic testing in microreactorsand theoretical modeling.[8-12]3) The challenge of nanobiointerfaces: from the understanding towards control of the interaction ofnanomaterials with biomolecules and cellsSince the emerging of nanobiotechnology from the intersection of materials research, nanoscience,molecular and cell biology [13], surfaces and interfaces appeared to play a key role in coupling the physicaland chemical features of nanosized matter with the sharp recognition capability of biomolecules and thefunctional specificity of cell signalling. This led to the definition of the “Biological Surface Science” concept[14], with the scientific challenges of i) mapping out biomolecule structures at surfaces and ii) addressinghow bio-functional surfaces participate in cell signalling. Moreover, biophysicochemical interactions at thenano-biointerface regulate the switch from biocompatible to bio-adverse outcomes [15].In particular the paradigm of the causal sequence: surface structure -> states of adsorbed/boundbiomolecules ->cell response is at the basis of the nano-biointerface research proposed in this application,which involves:a) nanoparticles for in situ & in vivo diagnostic and therapeuticb) nanostructured surfaces of materials for implants and biosensors.In this research interdisciplinary area beside collaboration common characterization and modelling methods,innovative synthesis methods ,cell signalling studies and device physics are involved.These three research lines in surface nanotechnology are also part of several ongoing collaborativeprojects between the NIS Centre and other national and international institutions and companies. Thesesynergies are essential to the project both for achieving the research goals and as reference technologyscenarios. This partnership is testified by the attached endorsement letters.

12 Project description (specific aims, design, methods, time schedule of

study/experiments)

LINE 1: SOLID-SOLID INTERFACES

Research activities of this section aim at tailoring materials by optimisation of their internal structure, i.e.solid-solid interfaces. Some are then exploited for applications listed in Lines 2 and 3. Others are meant fordevice components in that their properties are obtained via specific patterning or microstructure design atthe micro- or nano-scale.Task 1.1: Patterning

Paths in diamond films

On the basis of several years experience at NIS,diamond is an ideal platform for microdevices and sensorsconstruction by fine-tuning the surface structure at micrometer level by means of implantation of MeV ionbeams. By this method transformation of the diamond phase to graphitic zones leads to conductive graphiticpaths, 3D microstructures and optical waveguides located on crystalline diamonds films [16]. More in-depthinvestigation of the graphite/amorphous C/diamond interfaces is required to fine control of the electricalconductivity, refractive index, chemical reactivity and biocompatibility.Modelling will be used as a tool to interpret results or as the preliminary source of information to reduce thenumber of experiments. Investigation at the ab-initio level of the structural, electronic, elastic, magnetic,vibrational and thermodynamic properties of graphitic products [17,18] will be performed with the quantummechanical computer code CRYSTAL implemented at NIS.Superconductor-insulator interfaces

High-temperature superconducting oxides can be described as a sequence of nanometricsuperconductor/insulator layers representing intrinsic Josephson junctions (IJJs) [19]. This is why suchoxides can emit and detect THz electromagnetic waves, with applications in IT and medical sciences. Stacksof IJJs are made out of these oxides by means of photolithographic and Focused Ion Beam (FIB) techniques(available at INRIM-Nanofacility Piemonte). The heating and irradiation damage of the stacks duringfabrication will be investigated and samples will be characterized by transport techniques (DC and GHz/THzregimes), XRF and XRD, including synchrotron radiation.Electron transport in defective oxide semiconductors

On the basis of well established experience at NIS the conductive properties of mixed or doped oxidesdeveloped via sol gel, hydrothermal and CVD synthesis depend upon particle/particles contacts. Doping with


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metal particles or mixing with other oxides play a basic role in surface micro-patterning and consequently onthe transport of photo-generated electrons through the semiconductor [20,21]. Along this line the Au/TiO2and TiO2/ZrO2 systems will be specifically investigated by means of current-voltage or capacitance-voltagemeasurements. The influence of metal deposition and of atmosphere will be studied by conductive-AFM,which allows to map simultaneously the topography and current distribution under illumination.Task 1.2: Microstructure design

Porous Au

De-alloying of solid solutions of noble metals results in nanoporous thin films for applications in catalysis andelectronics. Difference in electrochemical potential between alloy components, critical potential forcorrosion, suitable noble element content (parting limit) are needed. Ligaments and pores then form either byinterfacial or volume diffusion. Dealloying of amorphous alloys, homogeneous in composition, having nograin boundaries is less known [22]. Contrary to crystalline alloys, here nucleation of crystals must occur.Process parameters will be tailored to obtain porous nanostructures supported by the alloy itself andsubsequently to design patterns with them.Polymer Nanocomposites

After organoclays [23], the most promising fillers in polymer nanocomposites (PNs) are carbon nanotubes(CNTs) and graphenes. With addition of CNTs, not only the mechanical properties of PNs are enhanced butalso conductivity. Electromagnetic interference shielding and sensing capabilities may be imparted topolymers [24]. Graphene sheets provide an alternative option due to their excellent conductive propertiesand the different aspect ratio. Graphene exfoliation, filler dispersion, percolation threshold and distributionwill be investigated for polymers of interest for automotive industry, e.g. polypropylene, and correlated withtheir mechanical, electrical conductivity properties.Smart composites

Graphene-polyurethane PNs will be investigated as barrier materials for gases, e.g. O2, exploiting the“tortuous path” principle. Elastomeric thermoplastic materials may also be capable of sensing local changesin properties of material/environment, with application in the Aerospace sector. This will be achieved byeither patterned thin film deposition or embedding spun magnetic wires of amorphous-nanocrystalline alloysin the (Fe-group metal)-Cu-Si-B system [25]. Here the control of nucleation of crystal phases in thesynthesis and processing is of paramount relevance for producing varied shapes of magnets. As aby-product, the same magnetic materials are relevant to the design of pressure sensors for chemical plants.

LINE 2: SOLID-GAS AND SOLID-LIQUID INTERFACES

This section outlines the research activities which exploit the specific expertise available at NIS toinvestigate surface-molecule interactions with experimental and theoretical techniques.Task 2.1: New materials for gas purification /storage or encapsulation

i) Development of robust and selective high capacity hybrid materials for the capture of small molecules

Thanks to their intrinsic properties (high surface area, modular synthesis and tunable pore surface


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properties) Metal Organic Frameworks (MOFs) have potential applications as gas storage and separationmaterials [26]. The proposed study will develop new MOFs for CO2 separation from power plant flue gasstreams, capture CO from CO/H2 syn gas mixture and O2 from air for oxyfuel combustion [27]. Newmaterials are under study in order to improve selectivity, storage-capacity and stability. The methodologyincludes synthesis (in collaboration with Berkeley, Oslo and Como universities) and characterization with amulti technique approach (structural and spectroscopic studies in controlled atmosphere, in combination withsorption measurements and computational methods) [28].ii) New organic-inorganic encapsulation complexes

Encapsulation into porous inorganic structures provides a method for stabilization, tuning of properties andtransport of functional molecules. This project aims at the design, synthesis and characterization of opticallyand chemically functional composites based on encapsulation of guest molecules into host microporousmatrices. In particular, inclusion compounds based on clay minerals and silicates with 1- or 2-D channels willbe studied, with focus on stabilization of unstable functional dyesTask 2.2: Tailor-made catalytic materials with high activity and specificity

Supported noble metal NPs for biomass feedstocks conversion and fine chemicals synthesis.

Noble metal nanoparticles on microporous supports are efficient catalysts for many relevant industrialconversions of fine chemicals. Among these, the present project concerns primarily selectivehydrogenations of fine chemicals on Pd/Rh catalysts[29] (in collaboration with Chimet S.p.A.) and oxidationreactions of furfurals on gold catalysts, a key step in the conversion of biomass to fuels [30]. Detailedknowledge of the interactions of reactants and products with the catalyst surface is essential inunderstanding the activity and selectivity of catalysts [8,10,11]. A systematic study of the role of thesupports, preparation methods of the microstructure, dispersion and capability in the activation of themolecules involved in the reactions will be made.Development of new zeolites for hydrocarbon synthesis, for mild oxidations and for the conversion of

pollutants

Single isolated metal ions or protons in zeolites probably represent the closest inorganic counterpart of anenzyme, and zeolitic catalysts have proved highly active and selective in many industrial processes[11].Today, the global shift in available feedstocks and the availability of new zeolites with different topologiesand hierarchical properties, opens new perspectives in this area. Within this project, we propose: a) thestudy of novel hierarchically porous acidic zeolites for gas-to-liquid processes [31]; b) the study of anisomorphously substituted Ti-CHA in oxidation of propylene with H2 O2 [32] and; c) a critical comparison ofFe- and Cu-zeolites in deNOx catalysis processes [10] (in collaboration with University of Oslo and HaldorTopsøe A/S).Increasing the activity of semiconducting oxides in photocatalysis

Photocatalysis is involved in photoelectrochemical processes, treatment of industrial waste streams,environmental remediation and “smart” self-cleaning surfaces. It is generally accepted that application ofthese technologies is limited by the low activity of photocatalysts, and by their inability to exploit visible solarradiation. To date, the relationship between surface structure and activity remains unclear. In the presentproject we propose a thorough study of the surface structure and interaction with probe molecules in TiO2

photocatalysts, coupled with photo-activity tests in gas phase reactions, in order to investigate structure-activity relationships [33,34] The materials investigated will be both structurally well defined materialsprepared ad-hoc and novel high surface area TiO2 phases. These activities are partially in cooperation withBASF and Buzzi Unicem.


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LINE 3:TACKLING THE CHALLENGE OF NANOBIOINTERFACES from the understanding towards the

control of the interaction of nanomaterials with biomolecules and cells :This line concerns the study of nanobiomaterials, their interfacial behaviour towards biomolecules and thesubsequent interaction with cells, including their potential toxicity, as depicted in the scheme below. Severalsystems will be investigated, from mobile NPs to biosensors, complementary in terms of their properties andfunction.Task 3.1: Elucidation of the surface structure of biomaterials for bone repairing and fundamental

aspects of their interaction with biomolecules

Nanomaterials considered:

- Nanohydroxyapatites (nano-HA) are highly investigated because biomimetic and resorbable [35]- Bioactive silica-based glasses engineered with Au NPs, of interest for of the variety of possible surfacecoatings (bio-functionalization) and good biocompatibility [36]As for nano-HA, the main target will be the advance in molecular understanding of the contact betweenfunctional groups of biomolecules and the material surface. Focal point will be the synergy between thepreparation of HA NPs with well defined surfaces (investigated by HR-TEM), and the investigation ofadsorbed biomolecules by molecular spectroscopies and quantum mechanical modelling.As for bioactive glasses bearing Au NPs, the possibility to anchor bioactive molecules (or even enzymes) onmetal sites will be exploited, as an innovative contribution to the fields of biocompatibility improvement andcontrolled drug delivery systems.Task 3.2 Cyanine-doped silica NPs for cell tracking and labelling.

Nanomaterials considered:Silica NPs (diameter 50 nm) hybridized with fluorescent indocarbocyanine molecules, are attractive for thehigh homogeneity of size and shape and photoluminescence brightness [37]Here the focus will be on the detailed investigation of:- optimisation of the dispersion of photoluminescent molecules within silica NPs prepared W/Omicroemulsion, by controlling the relative partition of fluorophores and molecular precursors of silica (TEOS);- properties which modulate the tissue response to a foreign body, such as hydrophilicity/hydrophobicity,protein adsorption and modification, surface charge, Z potential;- mechanism of interaction between NPs and the membrane of neuronal and endothelial cells, by analyzingtheir response in terms of changes in functional parameters such as calcium homeostasis, and subsequentlyto test their utilization in cell tracking.Our aim is to obtain a new generation of highly biocompatible fluorescent nanosensors, simple to prepareand store, easily incorporated by cells without complex surface functionalization.Task 3.3 Porous Silicon Biosensor for Arachidonic Acid Detection

Nanostructured material considered:

Porous silicon (PS) exhibits many advantages: high specific surface area (ca. 200 m2/g), relativelyeasy/cheap fabrication processes, biocompatibility.


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Arachidonic acid (AA) is a membrane permeant second messenger that plays key roles in manyphysiological and pathological processes [38]. Due to its lability, no efficient AA detectors have beendeveloped to date. Preliminary results indicate the potential effectiveness of an enzyme-based sensorconsisting in a cytochrome P450 engineered with a single cysteine that covalently binds a fluorophorereporter group which changes its optical properties upon AA binding. The first step will be to immobilize thesensor on a PS substrate on which neurons and endothelial cells can be grown, in order to detectextracellular AA released from the cells;The second step will be to optimize its insertion into the cells to obtain a detector of intracellular AAproduction and localization.Task 3.4 Interfacing nanocrystalline diamond microchips with excitable cells for recording optical

and electrical events associated to neurotransmitter release and cell excitability

Nanostructured material considered:

Nanocrystalline diamond (NCD) surfaces covered with adhesion proteins offer outstanding features forinterfacing excitable cells and constructing microelectrode arrays (MEAs) able to detect electrical events,optical signals and “quanta” of neurotransmitter molecules released from neurons and neurosecretory cells.In this project we plan to improve a 2x2 boron-doped NCD MEA developed in collaboration with the group ofDr.Pasquarelli (Ulm, Germany) [39] following two main strategies by constructing: i) a 3x3 MEA covering thetotal area of a single cell to be used for monitoring secretion in the sub-micrometer range of the cell, and ii) a4x4 MEA of 20 micrometre diameter separated by 200 micrometre. This new microarray will detectamperometric signals associated with released neurotransmitters, electrical events and fluorescence Ca2+signals from neuronal networks grown on the surface. The functional properties of the monocrystallinediamond microchips with conductive graphitic pathways described in Task 1.1 will be also tested. The newdiamond-based biosensors may overcome most of the intrinsic limitations of commercially available MEAsand offer the possibility of multi-parametric analysis on neuronal, cardiac and neuroendocrine cells.

Concerning the time schedule of the research activities described in the previous sections, due to thecomplexity of the subjects, no single synchronized schedule can be given to all research lines. In fact someproject are still in a very preliminary phase, while others are a continuation of ongoing projects.A unified internal monitoring system will be planned allowing to stimulate and verify at regular times theprogress of all the research units. This form of monitoring and reporting may be organized in form of publicseminars. Moreover, the NIS Centre has a scheduled evaluation plan of its activities based on bibliometricmethods and collection of non-bibliometric deliverables, which will also be beneficial to the project.

13 Role of investigators


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Prof. Adriano Zecchina, Emeritus Professor, Fellow of the “Accademia dei Lincei” and Director of the NISCentre, supervises and stimulates the scientific activities of NIS also within the present project and chairsits internal evaluation group which is in charge of monitoring the project development.Prof. E. Vittone will coordinate the activities on the controlled modification of diamond by ion irradiation,which require a synergetic approach involving competencies and instrumentation available at NIS (diamondcharacterization, functionalization, laser processes), at the Nanofacility Piemonte of INRiM (for FIBmicromachining) and at the Ruder Boskovic Inst. of Zagreb (HR) (ion beam implantation). He will be alsoinvolved in the electronic transport analysis of the IJJs stack. D. Gatto Monticone is involved in thedevelopment and realization of conductive graphitic channels in diamond and in the study of the opticalproperties of the irradiated diamond.Prof. R. Dovesi, Director of the Dipartimento di Chimica IFM, leader of the Theoretical Chemistry Group,coordinates the development of the quantum mechanical modelling software CRYSTAL at NIS. This softwarepackage will be used extensively for the investigation of the structural, electronic, elastic, magnetic,vibrational and thermodynamic properties of graphitic materials, as well as in other areas of the project (line2 and 3).Prof. L. Operti is coordinating the activity concerning the growth and characterization of thesuperconducting microcrystals used as starting points for the IJJs stack fabrication. Dr. A. Agostino isinvolved as an expert in XRD and XRF analysis techniques that will be used for the characterization both ofthe pristine crystals and the IJJs stacks. Dr. S. Cagliero is performing the crystal growth and electricalcontacting. He will also carry out the characterization and data analysis in DC regime and the XRD dataanalysis. Dr. M. Truccato will be responsible for the patterning of the IJJs stacks by means ofphotolithographic and FIB techniques. He will also finalize the results of data analysis. Dr. C. Paganini andC. Gionco activities are devoted mainly to the synthesis and the EPR spectroscopic characterization ofsemiconducting mixed or doped oxides developed via sol gel, hydrothermal and CVD syntheses. Current-voltage or capacitance-voltage measurements in the grain volume or at their surface will be performed withinthe PhD activities of A. Cultrera.Prof. L. Battezzati, leading scientist in rapid solidification of alloys, will coordinate the activities inmetallurgy. The study of de-alloying and characterization of metallic glasses will be done with the help of Dr.G. Fiore, while the study of thermodynamics of metastable phases and the kinetics of phase transformationswith focus on the nucleation of crystals is a topic of PhD studies of G. Dalla Fontana.Prof. D. Scarano and Dr. M. Zanetti will share their respective experience in the investigation of carbonbased materials (CNTs, Graphenes) and polymers, with the aim to develop new polymer nanocomposites(PNs). The long standing experience in the synthesis of carbon nanotubes nanocomposites will be exploitedin producing graphenes PNs. The morphology of the composites (carbon nanotubes dispersion, grapheneexfoliation and dispersion, percolation threshold and distribution) will be investigated by means of severaltechniques, TEM, AFM,SEM, XRD , Raman, thermal analyses ecc with the contribution of Dr. G. Agostiniand Dr. A. Damin. Dr. F. Cesano, who has pioneered the carbon materials synthesis at NIS, together withPhD student G. Haznedar will be involved in the synthesis processes and characterization techniques.Prof. S. Bordiga, principal investigator of the project, will supervise the management of the project incollaboration with NIS Director. On the scientific ground, Prof. Bordiga’s long standing experience on “in situ“characterization of microporous materials with spectroscopic techniques, will be exploited in the activitieson hybrid materials and zeolites as sorbents and catalysts. Volumetric and calorimetric measurements, willbe carried out by Dr. J. G. Vitillo, while the spectroscopic analysis perfomed on MOfs and on zeolites will beunder the supervision of Dr. F. Bonino. The activities related to Fe-zeolites will be part of the PhD work ofC. Barzan.Prof. C. Lamberti will coordinate the experiments foreseen at synchrotron radiation sources (X-raydiffraction and X-ray adsorption and emission spectroscopies), a complex task requiring also the design ofthe experiment and the obtainment of beam time. Dr. G. Agostini will be in charge of the structural andmorphological analysis of nanostructured heterogeneous catalysts (mainly by HRTEM and XRPD). Activitiesrelated to gold nanoparticles catalysts will be supervised by Dr. M. Manzoli.Dr. R. Giustetto, mineralogist will coordinate the study of encapsulated organic molecules in collaborationwith Dr.G. Ricchiardi. G. Ricchiardi also collaborates to experimental catalysis studies.Dr. M. Chierotti has a great experience in solid-state NMR characterization of both organic and inorganicmaterials. Dr. Chierotti and K. Gaglioti will investigate and characterize zeolites (in particular surfaces,silanol acidity and catalytic sites) and organic-based pigments (focusing on host-guest weak interactions) bymeans of advanced (multinuclear and multidimensional) solid-state NMR measurements.Prof. P. Ugliengo is an expert in computational prediction of molecule-solid interactions. He will lead themodelling study of biomaterials, in particular concerning the structure and reactivity of hydroxyapatite and itssurfaces in interaction with adsorbates.Related experimental investigation will be supervised by Prof. G. Martra, who will also be in charge on the


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study of molecular aspects of potential toxicity, with the support of Dr. F. Turci.Experimental research activities concerning the surface interaction with biomolecules and other species ofbiological interest of bioactive glasses functionalised with gold nanoparticles will be carried out by Dr. V.Aina and Prof. C. Morterra.Dr. P. Quagliotto will apply his expertise in the controlled preparation of high brightness hybrid silica-fluorophores nanoparticles, that will be used by S. Antoniotti, A. Gilardino and Prof. D. Lovisolo innanoparticles/proteins/cells interaction investigations. PhD students: F. Ruffinatti, T. Genova and G.Catucci will perform neuronal calcium imaging, single cell and populational Fluo microscopy andmutagenesis, fluo labelling and immobilisation on surfaces, respectivelyProf. L. Munaron and Dr. S. Sadeghi will join their expertises in cell signalling related to the production ofarachidonic acid (AA) and exploitment of the functional feature of P-450, respectively, will collaborate for thedevelopment of a porous-silicon based device for AA detection.Prof. E. Carbone’s team (C. Calorio, C. Franchino, D. Gavello, S. Gosso)in collaboration with UlmUniversity will focus its activity on the set-up of new nanocrystalline diamond based microchips for thedetection of signals associated with neurotransmitter molecules released from neuronal networks.All the participants are involved in promoting their research activities participating to specific collaborativeprojects funded at regional, national and european level. The project staff is also involved in severalindustrial collaborations on the subjects of the present project. Endorsement letters by companies andinstitutions interested in the development of the present project are in the “attachements” section.

14 References

[1] S. Castelletto, J. P. Harrison, L. Marseglia, A. C. Stanley-Clarke, B. C. Gibson, B. A. Fairchild, J. P.Hadden, Y-L. D. Ho, M. P. Hiscocks, K. Ganesan, S. T. Huntington, F. Ladouceur, A. D. Greentree, S.Prawer, J. L. O’Brien and J. G. Rarity, Diamond-based structures to collect and guide light, New J. Phys. 13,(2011), 025020.[2] M. Tonouchi, Cutting-edge terahertz technology, Nat. Photonics 1, (2007), 97-105.[3] http://www.theochem.unito.it/crystal_tuto/mssc2008_cd/tutorials/index.html.[4] M. Zanetti, G. Camino, R. Thomann and R. Mülhaupt, Synthesis and Thermal Behaviour of LayeredSilicate-Eva Nanocomposites, Polymer 42, (2001), 4501-4507.[5] S. Morandi, M.C. Paganini, E. Giamello, M. Bini, D. Capsoni, V. Massarotti and G. Ghiotti, Structural andspectroscopic characterization of Mo1-xWxO3- mixed oxides, J. Solid State Chem. 182, (2009),3342–3352.[6] J. Erlebacher and R. Seshadri eds, Hard Materials with tunable Porosity, MRS Bulletin 34, (2009),561-566.[7] A. Inoue and N. Nishiyama, New bulk metallic glasses for applications as magnetic-sensing, chemical andstructural materials, Mater. Res. Bull. 32 (2007) 651.[8] C. Lamberti, E. Groppo, G. Spoto, S. Bordiga, and A. Zecchina, Infrared Spectroscopy of TransientSurface Species, Adv. Catal. 51, (2007), 1-74.[9] A.M. Walker, B. Civalleri, B. Slater, C. Mellot-Draznieks, F. Cora, C.M. Zicovich-Wilson, G. Roman-Perez, J.M. Soler and J.D. Gale, Flexibility in a Metal-Organic Framework Material Controlled by WeakDispersion Forces: The Bistability of MIL-53(Al), Angew. Chem.-Int. Edit. 49, (2010), 7501-7503.[10] C. Lamberti, A. Zecchina, E. Groppo and S. Bordiga, Probing the surfaces of heterogeneous catalystsby in situ IR spectroscopy, Chem. Soc. Rev. 39, (2010), 4951-5001.[11] A. Zecchina, E. Groppo and S. Bordiga, Selective catalysis and nanoscience: An inseperable pair,Chem.-Euro J. 13, (2007), 2440-2460.[12] R. Dovesi, B. Civalleri, R. Orlando, C. Roetti and V.R. Saunders, Ab initio quantum simulation in solidmate chemistry, Rev. Comput. Chem. 21, (2005), 1-125.[13] C.M. Niemeyer, Hapten-functionalized DNA-streptavidin nanocircles as supramolecular reagents in acompetitive immuno-PCR assay, Angew. Chem. Int. Ed. 40, (2001), 4128-4158.[14] B. Kasemo, Biological surface science, Surf. Sci. 500, (2002), 656-677.[15] A.E. Nel, L. Madler, D. Velegol, T. Xia, E.M.V Hoek, P. Somasundaran, F. Klaessig, V. Casanova andM. Thompson, Understanding biophysicochemical interactions at the nano-bio interface , Nat. Mater. 8,(2009), 543-557.[16] P. Olivero, G. Amato, F. Bellotti, S. Borini, A. Lo Giudice, F. Picollo and E. Vittone,Direct fabrication and IV characterization of sub-surface conductive channels in diamond with MeV ionimplantation, Eur. Phys. J. B - Condensed Matter and Complex Systems 75, (2010), 127-132.[17] Ph. D’Arco, Y. Noel, R. Demichelis and R. Dovesi, Single-layered chrysotile nanotubes: A Quantum-


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Mechanical ab-initio simulation, J. Chem. Phys. 131, (2009), 204701.[18] Y. Noel, Ph. D’Arco, R. Demichelis, C.M. Zicovich Wilson and R. Dovesi, “On the use of symmetry inthe ab-initio quantum-mechanical simulation of nanotubes and related materials”, J. Comput. Chem. 12,(2010), 855-662.[19] M. De La Pierre, S. Cagliero, A. Agostino, G.C. Gazzadi and M. Truccato, Size-dependent resistivity ina micro-processed YBa2Cu3O7-delta superconducting whisker, Supercond. Sci. Technol. 22, (2009),045011.[20] S. Livraghi, F. Olivero, M.C. Paganini and E. Giamello, Titanium ions dispersed into the ZrO2 matrix:Spectroscopic properties and photoinduced electron transfer, J. Phys. Chem. C 114, (2010), 8553-18558.[21] A.M. Czoska, S. Livraghi, M.C. Paganini, E. Giamello, C. Di Valentin and G. Pacchioni, Thenitrogen-boron paramagnetic center in visible light sensitized N-B co-doped TiO2. Experimental andtheoretical characterization, Phys. Chem. Chem. Phys. 13, (2011), 136-143.[22] L. Battezzati and F. Scaglione, De-alloying of rapidly solidified amorphous and crystalline alloys, J.Alloy. Compd. doi:10.1016/j.jallcom.2010.12.209.[23] S. Barus, M. Zanetti, M. Lazzari, and L. Costa, Preparation of polymeric hybrid nanocomposites basedon PE and nanosilica, Polymer 50, (2009), 2595-2600.[24] S. Barus, P. Bracco, S. Musso, A. Chiodoni, A. Tagliaferro and M. Zanetti, Influence of MWCNTmorphology on dispersion and thermal properties of polyethylene nanocomposites, Polym. Degrad. Stabil. 5,(2010), 756-762.[25] R. Piccin, M. Baricco, P. Tiberto, N. Lupu and H. Chiriac, Thermal and Magnetic Properties in(FeBSi)NbY Bulk Glassy Alloys, IEEE TRANSACTIONS ON MAGNETICS, 46 (2010) 393-396[26] Themed Issue on Metal Organic Frameworks Chem. Soc. Rev. 38, (2009), 1201-1476.[27] L.J. Murray, M. Dinca, J. Yano, S. Chavan, S. Bordiga, C.M. Brown and J.R. Long, Highly-Selective andReversible O2 Binding in Cr3(1,3,5-benzenetricarboxylate)2, J. Am. Chem. Soc. 132, (2010), 7856-7857.[28] L. Valenzano, B. Civalleri, S. Chavan, S. Bordiga, M.H. Nilsen, S.R. Jakobsen, K.P. Lillerud and C.Lamberti, Disclosing the Complex Structure of UiO-66 Metal Organic Framework: A Synergic Combination ofExperiment and Theory, Chem. Mater. 23, (2011), 1700-1718.[29] R. Pellegrini, G. Leofanti, G. Agostini, L. Bertinetti, S. Bertarione, E. Groppo, A. Zecchina and C.Lamberti, Influence of K-doping on a Pd/SiO2-Al2O3 catalyst, J. Catal. 267, (2009), 40-49.[30] G.W. Huber, S. Iborra and A. Corma, Synthesis of transportation fuels from biomass: Chemistry,catalysts, and engineering, Chem. Rev. 106, (2006), 4044-4098.[31] F. Bleken, W. Skistad, K. Barbera, M. Kustova, S. Bordiga, P. Beato, K.P. Lillerud, S. Svelle and U.Olsbye, Conversion of methanol over 10-ring zeolites with differing volumes at channel intersections:comparison of TNU-9, IM-5, ZSM-11 and ZSM-5, Phys. Chem. Chem. Phys. 13, (2011), 2539-2549.[32] S. Bordiga, A. Damin, F. Bonino, G. Ricchiardi, C. Lamberti and A. Zecchina, The structure of theperoxo species in the TS-1 catalyst as investigated by resonant Raman spectroscopy, Angew. Chem.-Int.Edit. 41, (2002), 4734-4737.[33] S. Livraghi, M.C. Paganini, E. Giamello, A. Selloni, C. Di Valentin and G. Pacchioni, Origin ofphotoactivity of nitrogen-doped titanium dioxide under visible light, J. Am. Chem. Soc. 128, (2006),15666-15671.[34] S. Usseglio, A. Damin, D. Scarano, S. Bordiga, A. Zecchina and C. Lamberti, (I2)n encapsulation insideTiO2: A way to tune photoactivity in the visible region, J. Am. Chem. Soc. 129, (2007), 2822-2828.[35] P. Canepa, F. Chiatti, M. Corno, Y. Sakhno, G. Martra and P. Ugliengo, Affinity of hydroxyapatite (001)and (010) surfaces to formic and alendronic acids: a quantum-mechanical and infrared study, Pys. Chem.Chem. Phys. 13, (2011), 1099-1111.[36] V. Aina, T. Marchis, E. Laurenti, E. Diana, G. Lusvardi, G. Malavasi, L. Menabue, G. Cerrato and C.Morterra, Functionalization of Sol Gel Bioactive Glasses Carrying Au Nanoparticles: Selective Au Affinity forAmino and Thiol Ligand Groups, Langmuir 26, (2010), 18600-18605.[37] I. Miletto, A. Gilardino, P. Zamburlin, S. Dalmazzo, D. Lovisolo, G. Caputo, G. Viscardi and G. Martra,Highly bright and photostable cyanine dye-doped silica nanoparticles for optical imaging: Photophysicalcharacterization and cell tests, Dyes Pigment. 84, (2010), 121-127.[38] A.F. Pla, T. Genova, E. Pupo, C. Tomatis, A. Genazzani, R. Zaninetti and L. Munaron, Multiple Roles ofProtein Kinase A in Arachidonic Acid-Mediated Ca2+ Entry and Tumor-Derived Human Endothelial CellMigration, Mol. Cancer Res. 8, (2010), 1466-1476.[39] V. Carabelli, S. Gosso, A. Marcantoni, A. Pasquarelli, Y. Xu, E. Colombo, Z. Gao, J. Scharpf, E. Kohnand E. Carbone, Quantal release detection of catecholamines from chromaffin cells by nanocrystallinediamond microelectrode arrays fabricated on sapphire technology, Biosens. Bioelectron. 26, (2010), 92-98.


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15 Budget

Cost Description

15.1 Post Doctoral

Fellows to be hired for

project

450.000

15.2 Equipment and

software

0

No new equipment will be charged on this project

15.3 Direct costs 190.000

Accessories for spectroscopy and for high vacuum manyfolds;celles in opticalquartz. Reagents, pure gases, glassware, liquid nitrogen, solvents,plasticware, buffer agents chromatographic media, cell culturemedia. Electroc components and consumables

15.4 Travels 42.000

Expences to partecipate to conferences devoted to the projecttopics. Travels and stay costs at synchrotron facilities.

15.5 External services 38.000

Maintenance contracts for the equipments that are used for theproject (19000 each year)

15.6 General expenses 80.000

General maitenance costs of the laboratories, running project costs,phone,workshop. Other expenses directly connected with theresearch activities

TOTAL 800.000

16 Animal Experiments

Does the project require the use of experimental animals according to DL 116 of 27.01.1992? NO

17 Statement

I authorize the use of the informations contained in the project for the purposes of scientific

evaluation

YES

I authorize the dissemination of the outcome of scientific evaluation of the project YES

Questionario obbligatorio per la linea A


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Assunzione di giovani

ricercatori (max 34 anni)

SI

Si intende assegnare un numero totale di 18 annualità come contrattidi assegno di ricerca. Le tematiche inerenti alle attività dei ricercatorisono riportate nella sezione 9.5 del progetto.

Cofinanziamento /

finanziamento di soggetti

esterni (pubblici o privati)

all'ASSUNZIONE di giovani

ricercatori (max 34 anni)

SI

Complessivamente si prevede l'estensione dei contratti per giovaniricercatori per un totale di 7 annualità a valere su: ConsorzioInteruniversitario Nazionale per la Scienza e Tecnologia dei Materiali,C.F. 94040540489, P.IVA 04423980483 (2 annualità); Fondi derivantidai 2 progetti europei citati nella sezione successiva; 1 annualità suiprogetti STEPS e SMATs della Piattaforma Aerospazio; 1 annualitàderivante da un contratto con l'ENI, Istituto Guido Donegani, 1annualità su fondi del Polo di Innovazione MicroDiBi finanziato dellaRegione Piemonte

Risultati con potenziale

miglioramento di servizi

territoriali

SI

Alcuni temi del progetto sono oggetto di collaborazioni con PMI delterritorio, anche attraverso lo spin-off NISLabVCO presso iltecnoparco del lago Maggiore.

Attività di ricerca

congiunta con soggetti

privati

SI

Molti dei partecipanti al progetto hanno attualmente in corso delleattività di ricerca congiunta con aziende sui temi trattati nel progetto.Qui di seguito sono riportati alcuni esempi:ABB P IVA IT 1988960156; nanocrystalline alloysCRF SCpA P IVA 07084569915; Carbon 6. Synthesis andcaracterization of carbon - polimer nanocompositesMagneti Marelli PIVA 06736870012;carbon based nanocomposite materialsChimet SpA P IVA IT00155440514;Supported noble metal nanoparticles as catalysts for fine chemicalsTopsoe VAT DK 41853816;Zeolitic materials as heterogeneous catalystsBuzzi Unicem SpA P IVA 01772030068photocatalytic materials for constructionSAES Getters S.p.A., C.F. e P.IVA 00774910152;new matrials for selective getters

La brevettazione dei

risultati della ricerca

SI

Le attività su nuovi materiali zeolitici o ibridi-inorganici-organici per lacatalisi e l'adsorbimento, in collaborazione con l'Università di Oslo econ Topsoe, potrebbero portare alla brevettazione di nuovi materialie/o nuove reazioni.la prototipazione del sistema per la rilevazione dell'acido arachinonicopuo' dare origine ad un device che potrebbe essere oggetto dibrevettazione"

La costituzione di spin-off SI

E' in fase di costituzione lo spin-off "IoniCh" per lo screening di farmaciutilizzando la tecnica dei MEA. Lo spin-off fa ora parte del progetto"Sovvenzione Globale" finanziato dalla Regione Piemonte


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Nell'ambito di un network

internazionale (europeo

e/o extraeuropeo)

esistente o in fase di

costituzione

SI

FP7-REGPOT project “BeyondEverest” Approved. Sofia (coordinator)TUM; Oxford; Max Planck, Unito, Ecole Superiore de Physique (Paris)FP7-NMP-2008-LARGE-2 NanoMOF—Nanoporous Metal-OrganicFrameworks for production.Devolopments of MOFs for storage, separation and purification ofnocive gases.Uni Granada,Tch. Univ. Dresden, SINTEF, Uni Torino, CNRS Lyon ,OUVRY SAS, Norafin GmbH, Oleon NV, Ben-Gurion University of theNegev, Innovatext Textile Engineering and Testing Institut Co, SocietàItaliana Acetilene e Derivati, TDL Sensors LTDEUROPEAN SPACE AGENCY THERMOLAB 2009-2011EUROPEAN PROJECT CAVNETMarie Curie Research Training Networks,L-type calcium channels in health anddisease.http://www.cav-net.orgEUROPEAN SPACE AGENCY THERMOPROP 2011-2013Ulteriori consolidate collaborazioni sono testimoniate dalle lettere diendorsement allegate alla domanda:Oslo UniBerkeley UniBarcellona UniImperial CollegeLeeds UniUlm Uni

Nell'ambito di una

rete/progetto nazionale di

ricerca

SI

Piedmont Region Converging technologies call 2007Titolo del progetto: Nanostructured antibacterial coatingsFinalità: Development of a technique to deposit silver nanoclusterdoped silica thin films with antibacterial functionality.Esperimento INFN FARE (FAsci Rarefatti in Esterno) Finalità:Development of new MeV ion beam techniques and instrumentation formaterial analysis and micro-modification.REGIONE PIEMONTE PIATTAFORMA AEROSPAZIOSMAT - Sistema di Monitoraggio Avanzato del Territorio 2009-2011REGIONE PIEMONTE PIATTAFORMA AEROSPAZIO STEPS - Sistemie tecnologie per l’esplorazione spaziale 2009-2011POLO REGIONALE MECCATRONICABonding in Al-based alloys 2010-2011Polo di Innovazione BioPMed Progetto di ricerca industriale e svilupposperimentale MicroDiBi: Microchips di diamante per “drug-screening” eapplicazioni biomediche Partners: NIS-Unito, INRIM, Politecnico,Crisel Instruments s.r.l., Politronica,BionicaTech, Trustech 2011-2013 REGIONE PIEMONTE Convergingtechnologies. Biotechnology - NanotechnologyMETREGEN Metrology on a cellular and macromolecular scale forregenerativemedicine 2009-2011technologies. Nanotechnology / New Materials - ICT NANOCONTACTCarbon Nanotubes based Conductive Composites Laser Activated forIntegrated Sensors, Switches and Wirings 2009-2011Ulteriori consolidate collaborazioni sono testimoniate dalle lettere diendorsement allegate alla domanda:Università di ModenaPolitecnico di TorinoINRIMAlcuni dei partecipanti al progetto sono inseriti in porgetti PRINattualmente attivi, per esempio Livio Battezzati (Processi di sintesi,studio delle trasformazioni di fase e delle proprietà di materiali


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magnetici innovativi) e Maela Manzoli (Caratterizzazione di catalizzatoriper la sintesi di molecole piattaforma per un'industria chimica basatasu fonti rinnovabili).Molti dei partecipanti al progetto hanno presentato domanda difinanziamento PRIN 2009.

Torino 15/04/2011 12:31

Allegato 1

Allegato 2

Allegato 3

Allegato 4

Allegato 5

Allegato 6

Allegato 7

Allegato 8

Allegato 9

Allegato 10

Allegato 11

Allegato 12

Allegato 13

Allegato 14

Allegato 15

Allegato 16

Allegato 17

.


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Documents

Università degli Studi di TORINO Ricerca scientifica ... · Università degli Studi di TORINO Ricerca scientifica finanziata dell'Università ... The scientific activity of Prof