CARDIOVASCULAR SCIENCES COLLABORATIVE PROGRAM

Faculty of Medicine, University of Toronto

ANNUAL REPORT2007 – 2008

FitzGerald Bldg., 150 College Street, Room 88, Toronto ON M5S 3E2Tel: 416/978-0746 Fax: 416/946-5713 E-mail: cv.program@utoronto.caWeb site: www.cscp.utoronto.ca

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CONTENTS

DIRECTOR’S REPORT………………………………………………………………………………….2

MISSION STATEMENT………………………………………………………………………………….3

COLLABORATING DEPARTMENTS…………………………………………………………………..3

COMMITTEES…………………………………………………………………………………………….4- Executive- Program

COURSES OFFERED…………………………………………………………………………………...5

PROGRAM SPONSORED ACTIVITIES……………………………………………………………….5- Annual Student Research Day- Student Forum Night- Cardiovascular Summer Initiative - CSI

AWARDS…………………………………………………………………………………………………10- Medtronic Travel Award- Bigelow Book Prize- Lorne Phenix Graduate Award- Ontario Student Opportunity Trust Funds (OSOTF) Award- Ontario Graduate Scholarships in Science and Technology (OGSST)

ADVERTISING MATERIAL…………………………………………………………………………….13

ACKNOWLEDGEMENTS………………………………………………………………………………13

STUDENTS………………………………………………………………………………………………14- Currently Enrolled- Convocated/Follow-Up- Awards and Honors- Publications

STUDENT ASSOCIATION SPONSORED ACTIVITY………………………………………………20- Circulation Rounds

FACULTY………………………………………………………………………………………………...21- Members- Peer Reviewed Funding- Awards and Honors- Publications

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DIRECTOR’S REPORT

Once again, it gives me great pleasure to provide this annual report highlighting the Cardiovascular Sciences Collaborative Program (CSCP) activities and accomplishments of our students and faculty over the 2007-2008 academic year. Thanks are also extended for the financial support from the Heart & Stroke Foundation of Ontario, Medtronic Canada, and the university which allowed the CSCP to continue to serve the university community, enhancing the graduate student experience for all our member Departments and Faculties.

The CSCP has shown a continued and sustained enrolment since its inception in 1992 (see graph below), where we began with a grand total of 5 students! The success of our recruitment initiative

is clearly shown as we now have a total of 56 (37 MSc and 19 PhD) enrolled students. The level of student satisfaction with the Program continues to be high as expressed during their annual meeting with the CSCP Student Affairs Committee Chair and the exit surveys we conduct. It is very satisfying to witness the growth and development of the CSCP over the past 15 years and seeing its’ entrenchment as a successful educational initiative of the Faculty of Medicine.

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1015202530354045505560

1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007

MSc

PhD

Total

Talks continue with our ongoing partnership with the University of Waterloo. We await the Faculty legal minds to provide us with a final draft of a Memorandum of Agreement and it is my fervent wish that the upcoming year will see this initiative become a reality.

We continue to experience increased enrolment in our graduate course offerings and now have fully established web-based learning for the JCV3000 series of graduate courses. Live and archived seminars are now fully integrated into our JCV3000 level courses, providing state-of-the-art learning technology for our trainees. I welcome this direction, as do all the students, and anticipate that this will also dove-tail nicely with our ongoing partnership initiatives.

With the progress made over the past year, our objectives for 2008-2009 are to continue with the momentum established and to redouble our efforts in areas that have been slow to advance – as detailed below:

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Finalize the agreement and launch the joint initiative with the University of Waterloo Further develop innovative curriculum to more appropriately serve the diverse nature of

this now multi-Faculty graduate training initiative Continue developing endowments to provide permanent infrastructure support Maintain active student recruitment Graduate training grant applications for both local and external agencies Further develop CME programs in cardiovascular sciences Maintain high standards of our full web-based courses

As you read through this report, you will see that the Program continues to enrich our trainee’s experiences. Specific details on all activities can be found on our web site at www.cscp.utoronto.ca. I would like to once again recognize the outstanding efforts of Victoria Simpson, our Business Officer, as well as the Executive Committee for their hard work and contributions that have made the Cardiovascular Sciences Collaborative Program the success it is today. And finally, I would like to take this opportunity to thank all our faculty and students for another successful year and to those individuals who have continued to provide both moral and tangible support for this Program.

Dr. Carin Wittnich, O.Ont.Director, CSCPProfessor of Surgery & PhysiologyNorthrop Frye Scholar

MISSION STATEMENT

“The Cardiovascular Sciences Collaborative Program, approved by the University and Ontario Council on Graduate Studies in 1992, and listed in the calendar of the School of Graduate Studies, exists to give formal, organized expression to cardiovascular studies and research at the graduate level. It builds on the strengths of all participating academic units, and other agencies, to enhance the visibility of cardiovascular studies and to facilitate collaborative, interdisciplinary training and research.”

The above mission is achieved by advertising and promoting the importance of, and opportunities in, cardiovascular studies, by making known the results of such studies, by recruitment of excellent students, and by coordinating the graduate collaborative program in cooperation with the academic units in which they are registered. Students in this collaborative program must fulfill the requirements of their home units as well as the Program. Upon graduation the notation “Specialization in Cardiovascular Sciences” will appear on the student’s academic transcript and the Program will present the student with a certificate and gift.

COLLABORATING FACULTIESDentistryMedicineNursingPharmacyPhysical Education and Health

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COLLABORATING GRADUATE UNITSBiomaterials and Biomedical EngineeringDentistryExercise SciencesHealth Policy, Management & EvaluationLaboratory Medicine and PathobiologyMedical BiophysicsMedical ScienceNursingPharmaceutical SciencesPharmacologyPhysiologyPublic Health SciencesRehabilitation Science

SUPPORTING CLINICAL DEPARTMENTSAnesthesia MedicineSurgery

COMMITTEES

ExecutiveThe Executive Committee consists of 4 members of the Program Committee representing as wide a range of disciplines as possible and includes the Director. They also act as Chairs of the various subcommittees as noted beside their name. The Executive Committee provides student counseling, screens applicants, provides advice and acts as a Steering Committee.

Dr. C. Wittnich (Fundraising)Dr. M. Rand (Scholarships & Awards)Dr. V. Rao (Membership/Curriculum)Dr. S. Thomas (Student Affairs)

ProgramThe Program Committee consists of a representative from each collaborating department as well as two student representatives. It administers the Program, selects the Director, and generally meets twice per year.

C. Wittnich (Chair)D. Brooks (Rehabilitation Science)S. Wu (Pharmaceutical Sciences)D. Mazer (Anesthesia)J. Parker (Pharmacology)S. Heximer (Physiology)D. Steinman (Institute of Biomaterials and Biomedical Engineering)M. Rand (Laboratory Medicine and Pathobiology)V. Rao (Institute of Medical Science)H. Tenenbaum (Dentistry)

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S. Thomas (Exercise Sciences)J. Tu (Health Policy, Management and Evaluation)J. Watt-Watson (Nursing)G. Wright (Medical Biophysics)President, CSCP Student AssociationVice-President, CSCP Student Association

COURSES OFFERED

EXS5508H Cardiovascular Disease and Exercise JCV1060H Developmental Cardiovascular Physiology JCV3060H* Advanced Topics in Cardiovascular Sciences – Molecular Biology & Heart Signal

Transduction JCV3061H* Advanced Topics in Cardiovascular Sciences – Hormones JCV3062H* Advanced Topics in Cardiovascular Sciences – Heart FunctionJCV3063H* Advanced Topics in Cardiovascular Sciences – Vascular JEB1365H Ultrasound: Theory and Applications in Biology and MedicineJTC1331H Biomaterials ScienceLMP1015H Vascular PathobiologyLMP1504H Cell and Molecular Biology of Cardiovascular DiseasesPSL1462H Molecular Aspects of Cardiac Function* Core Courses for PhD Trainees (2 of 4 modules required); JCV denotes joint listing with most of our collaborating departments.

Suggested Courses (Considered valuable but does not fulfill Program requirements)CHL5201 Introducing Biostatistics for Students in Biological SciencesLMP1404S Cellular and Molecular Mechanisms of DiseasePSL1052H Fundamentals on Ion Channel Function

PROGRAM SPONSORED ACTIVITIES

Annual Student Research DayOn February 21, 2008, the Cardiovascular Sciences Collaborative Program held its 9th Annual Student Research Day. This was a fun-filled day that was attended by All CSCP trainees. Dr. Wittnich began the day with her welcoming remarks. Selected students then presented their research concepts, designs or results in a series of 10 minute presentations followed by a 5 minute question period. The presentations were especially polished and professional this year, and covered a broad range of hot topics in cardiovascular research.

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SESSION I: Chair -- Shathiyah Kulandavelu9:15 Elissa Tepperman (MSc- Institute of Medical Science)

“Tacrolimus Preserves Endothelial-Dependent Vasomotor Function and Decreases Sensitivity to Vasospasm”

9:30 Mitesh Badiwala (PhD – Institute of Medical Science)“Donor Pretreatment with Hypertonic Saline Improves Coronary Artery Vascular Function Post-Cardiac Transplantation”

9:45 Maral Ouzounian (PhD – Institute of Medical Science)“Biomarkers to Distinguish Systolic from Diastolic Heart Failure”

10:00 Lara Gotha (MSc – Institute of Medical Science)“Arterial Injury & Intimal Hyperplasia in Heparan Sulfate-Deficient Perlecan Mice: The Effects of Induction of Perlecan”

10:15 Meghan Sauve (MSc – Institute of Medical Science)“The Role DPP-4 Inhibition in the Cardiovascular System”

10.30 Geoffrey de Couto (MSc – Institute of Medical Science)“cFLIP Modulates the Cardiac Hypertrophic and Fibrotic Response After Pressure-Overload and Angiotensin II Infusion”

SESSION 2: Chair -- Michael Ward 11:00 Tenille Ragoonanan (MSc – Department of Physiology)

“Acute Beta 1 Adrenergic Antagonism Inhibits Cerebral Oxygen Delivery Following Severe Hemodilution in Rodents”

11:15 Luka Srejic (MSc – Department of Physiology)“Spontaneous and Evoked Cortical Potentials in a Rat Focal Stroke Model In Vivo”

11:30 Katharine Currie (MSc – Department of Exercise Sciences)“The Effects of Short-Term Endurance Exercise Training on Vascular Function in Young Males”

11:45 Christy Hamilton (MSc – Department of Exercise Sciences)“NF-kB Activation in Peripheral Blood Mononuclear Cells Following Short Term Endurance Training”

12:00 Kumar Perampaladas (MSc – Department of Pharmacology)“Effect of Rosiglitazone on Nitroglycerin-induced Endothelial Function”

12:15 Kieran Quinn (MSc – Department of Physiology)“Human Neutrophil Peptides Induce Endothelial-Leukocyte Interaction and Accelerate Foam Cell Formation”

The afternoon component of the Research Day was highlighted by our Visiting Guests, Dr. Margaret Rand (R) and Dr. Saeid Babaei (L) -- two successful individuals in academia and

industry. An informal presentation was held where they shared the highs and lows of their career paths and life experiences with the students. Students were very delighted to meet Drs. Rand and Babaei, and this session was filled with enthusiastic discussions about their insights into the possible career paths for the students.

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Winners of the Bigelow Book Prize (Dr. Mitesh Badiwala, PhD/IMS, Supervisor: Dr. V. Rao), and the Phenix Graduate Award (Emma O’Donnell, PhD/EXS, Supervisor: Dr. J. Goodman) were announced. We were honoured to have the Bigelow and Phenix families present to hand out the awards.

Dr. Bigelow’s daughter, Pixie (left), was present to award the Bigelow Book Prize to Dr. Mitesh Badiwala (center) with Dr. Carin Wittnich (right)

Mrs. Phenix’s daughter, Karthryn (left), was present to award the Lorne Phenix Gradaute Award to Emma O’Donnell (center) with Dr. Carin Wittnich (right)

Certificates and gifts were presented to those students who had successfully completed the Cardiovascular Sciences Collaborative Program over the past year.

Adam Gwozda, MSc/IMS, Supervisor: Dr. M. RandKirsteen Burton, MSc/CHL, Supervisor: Dr. G. Tomlinson Danny Ramzy, PhD/IMS, Supervisor: Dr. V. Rao

This year's Research Day was again a successful event due to the combined efforts of many people. The members of the Planning Committee (Albert Tsui, Tenille Ragoonanan, and Laura Voicu) would like to thank everyone involved in making this day a success, including Drs. Rand and Babaei, the student presenters, the session Chairs, Shathiyah and Mike, the CSCP Business Officer, Ms. Victoria Simpson, and Dr. Wittnich, CSCP Director.

Student Forum NightThis event is an excellent opportunity for new students of the CSCP to meet one another and for senior students to catch up with old friends, and develop relationships with the up and comers. Discussions range from basic research, laboratory trials and triumphs, to future academic/career directions. Connections for research collaboration, as well as friendships are developed, and all those in attendance thoroughly enjoy the festive dinner and the change to meet other students. Due to a lack of funding we were unable to provide the CSCP student body with the 2007 CSCP Forum and Dinner. We hope to resume this event in 2008.

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Cardiovascular Summer Initiative (CSI) 2008This summer, the CSCPSA once again organized and ran the very exciting and successful Cardiovascular Summer Initiative. The series was targeted at undergraduate students involved in cardiovascular summer research, and aimed to give students a more inclusive feel for the field and to provide a broader frame of reference than just lab experience alone.

We began with an orientation session that outlined the role of the CSCP and the goals of our student association. Altogether, 18 students signed up for the Cardiovascular Summer Initiative with great student representation from research hospitals around the Toronto area (TGH, SMH, Sick Kids, PMH).

The next event was a mini-symposium showcasing the diversity of research within the CSCP. Six students within the collaborative program gave presentations: Mike Sellan, Kieran Quinn, Melanie Henriques, Christy Hamilton, Elissa Tepperman, and Andrew Ramadeen. The students really enjoyed the talks and demonstrated interest by posing meaningful questions about research methods and graduate studies in general.

CSI Mini Symposium 2008: Mike Sellan – ‘The effects of iron-overload on heart function’

CSI Mini Symposium 2008:Elissa Tepperman – ‘Tacrolimus preserves vasomotor function and decreases sensitivity to vasospasm’

CSI Mini Symposium 2008:Andrew Ramadeen – ‘The effect of fish oils on vulnerability in atrial arrythmias’

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The following three events were field trips/lab tours. Based on the feedback the CSCPSA obtained from the graduating students from the year previous, the committee attempted to structure this year’s outings in such a way that they would incorporate a diverse spectrum of material relevant to cardiovascular research.

The first event planned by the committee was set for the Surgical Skills Centre at the Mount Sinai Hospital. Students were kindly greeted by the staff and were informed, in a didactic lecture, about the complexities of surgical training and the state-of-the-art resources found at the Mount Sinai teaching hospital. Students were next taken for a tour of the facility, given the opportunity to watch some medical students dissect various tissues, and provided with the chance to ask questions on their facilities. Overall this day was well received by both staff and students.

The second event comprised a tour of the exercise laboratories in the Athletic Centre at the University of Toronto. Katharine Currie and Marc Busato, current graduating master’s students in the CSCP, kindly agreed to provide us with a tour of their research equipment and materials. Students were split into two groups: in Marc’s group students learned about VOmax and cardiac output using a stationary bicycle (CSI students, Anne Battisti [L], Tommy Rohani [M], with Mark Busato [R]), while in

Katharine’s group (left) students learned about blood pressure and wave forms while she recorded a student's cardiovascular function (Judy Qiang) while lying stationary on a bed.

Once again, this tour was very successful. Students provided excellent feedback and were genuinely interested in the hands-on aspect of this outing.

The third event organized by the CSCPSA was a tour of the Imaging Centre at St. Michael’s Hospital. Upon the organization of this event we were fortunate to have the opportunity to have two physicians, Dr. Louis Wu and Dr. Vikram Prabhudesai, provide lectures and tours of their facilities. The organization and willingness of the staff to cooperate with the CSCPSA was excellent. They were timely and extremely generous in providing everyone with a hot lunch, drink and dessert during the lecture sessions. Subsequent tours of the MRI and CT facilities were extremely informative. Although both imaging departments were busy, both physicians went out of their way to give an informative session with Q&As. At the end of the session, both physicians were presented with a certificate from the CSCPSA in gratitude of their help with the program.

The summer program wrapped up with student presentations of the work completed during each of their summer research sessions. Students were able to interact, learn and question the diversity of research performed by each field incorporated in the summer program. Subsequently students were presented with certificates and asked to provide feedback on this year’s program.

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The overall impression of the summer program was that it was very good. It provided an enjoyable learning environment and an opportunity to interact with several students outside of their lab. Each session was informative and well received. The major modification that was suggested by the student body was to have the sessions spaced out once every week rather than once every two weeks as done this year. We look forward to seeing this group as well as some new faces next summer.

AWARDS

Medtronic Travel AwardTwo competitions were held (spring and fall) for the Medtronic Travel Award. This award, established in 1995, helps to defray costs of travel for Program students presenting their research work at recognized scientific meetings. Students supported by this award this academic year were:

Fall 2007:No applications received.

Spring 2008:Rohit Sheshgiri, MSc, Institute of Medical Science (Supervisor: Dr. V. Rao)International Society for Heart & Lung Transplantation 28th Annual Meeting, Boston, Massachusetts, April 2008.“Soluble HLA-G is Negatively Associated With Allograft Rejection Following Heart Transplantation”

Elissa Tepperman, MSc, Institute of Medical Science (Supervisor: Dr. V. Rao)International Society for Heart & Lung Transplantation 28th Annual Meeting, Boston, Massachusetts, April 2008.“The Effect of Calcineurin Inhibition on Vasomotor Function and Visfatin Expression”

Bigelow Book PrizeThis prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to recognize and honor a pioneer clinician and scientist in the field of cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow - curiosity, drive, and scientific integrity. The award is given in every year that a qualified student is identified. Qualifications include sustained academic scientific excellence, innovative experimental approaches, original discoveries and good scientific productivity. Some weight is given to work that has recognizable clinical relevance, especially that which promises to improve patient care. The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious Heparin” and a keeper plaque created to honor Dr. Bigelow. Appropriate candidates are identified and the final decision is made by the Program Committee.

1995 – Dr. John S. Ikonomidis 2002 – Mr. Wm. Jack Wallen1996 – Ms. Shona M. Torrance 2003 – Dr. Paul W.M. Fedak1997 – Dr. Vivek Rao 2004 – Dr. Nathalie Lapointe1998 – Dr. Bryce Cowan 2005 – Dr. Karim Bandali1999 – Dr. Gideon Cohen 2006 – Mr. Danny Ramzy2000 – Dr. Michael Borger 2007 – Ms. Patricia Rose2001 – Dr. Saeid Babaei 2008 – Dr. Mitesh Badiwala

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A heart transplant is a priceless gift to a fortunate patient with end-stage heart failure. Regrettably, transplanted hearts develop a diffuse vasculopathy that limits their longevity. Dr. Badiwala is dedicated toward a career as a cardiac surgeon-scientist with an interest in developing novel strategies to preserve endothelial function and prevent cardiac allograft vasculopathy after heart transplantation. His PhD thesis focuses on evaluating novel endothelial protective strategies in the context of immunosuppressive therapy, on preventing neointimal hyperplasia after vascular injury. Dr. Badiwala is also defining the role of a novel endothelial chemoattractant protein, EGFL7, on the vascular endothelial response to hypoxia-reperfusion injury to determine whether it is a novel target for therapeutic intervention. His other research interests include investigating novel cardiac and endothelial protection strategies during donor heart preservation and cardiac transplantation.

Lorne Phenix Graduate AwardThis award was made possible by a generous donation in the memory of Mr. Lorne Phenix by Mrs. Geraldine Phenix. It is her hope that this award will focus attention on the issue of heart disease – which is still the #1 killer of both men and women in Canada. In addition, women who have heart problems are at least equal if not at greater risk than men and Mrs. Phenix hopes that this award will serve to encourage trainees to pursue this area of research to address this particular problem. It is awarded to a graduate student in the Faculty of Medicine on the basis of research and academic excellence. The award consists of a cash prize and certificate and is presented to the recipient at the Annual Student Research Day. Appropriate candidates are identified and a winner is selected by a subcommittee chaired by Dr. Donna Stewart. This award is presented at the Annual Student Research Day.

2001 – Wm. Jack Wallen 2005 – Nesime Askin2002 – Wm. Jack Wallen 2006 – Danny Quaglietta2003 – Shathiyah Kulandavelu 2007 – Emma O’Donnell2004 – Rachel Mitchell

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L-R: Pixie Currie, Dr. Mitesh, Badiwala, Dr. Carin Wittnich

L-R: Ms. Kathryn Phenix, Emma O’Donnell, Dr. Carin Wittnich

Emma O’Donnell is a PhD candidate in the Department of Exercise Sciences at the University of Toronto. Under the supervision of Dr. Jack Goodman and Dr. Paula Harvey, Emma’s thesis work is looking at estrogenic mechanisms of cardiovascular regulation in estrogen deficient premenopausal women. Discordance between the known biology of estrogen and the results of clinical trials of postmenopausal hormone therapy underscore the need to better characterize, in controlled mechanistic studies, estrogens multiple actions in human health and disease. Exercise-associated amenorrhea (EAA) is a common and reversible cause of estrogen deficiency in premenopausal women thought to be due to energy deficiency. Importantly, premenopausal women with EAA have estrogen deficiency similar to postmenopausal women and thus provide a unique model for examining the cardiovascular effects of estrogen independent of the effects of aging and the presence of other co-morbidities. Emma's previous work has shown that the women with EAA have disordered regional blood flow, blood pressure and heart rate when compared to exercising normally menstruating women. Her research will go on to examine: 1) the effects of estrogen on vascular function and oxidative stress, as well as neurohumoral mechanisms of vascular function and blood pressure regulation; and 2) to compare these responses in women with EAA in an estrogen deplete and replete environment. This will be achieved by testing women with EAA both before and after 4 weeks of transdermal estrogen therapy. Her work will also investigate whether estrogen deficiency due to EAA obviates the widely recognized cardiovascular benefits of habitual aerobic exercise and premenopausal status, and whether this might contribute to premature development of a cardiovascular phenotype more typically seen in postmenopausal women.

Ontario Student Opportunity Trust Funds (OSOTF) AwardThe OSOTF award refers to a class of awards that have resulted from the Ontario government’s “matching” program. Under the program every dollar of donation received for student assistance has been matched by the government as well as the university on a dollar-for-dollar basis. The Cardiovascular Sciences Collaborative Program participates in this program. There are two major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate financial need. However, the Program has additional eligibility criteria that must be adhered to, including excellence in science and academic performance. One competition is held per academic year. The applications are handled centrally through the Office of the Associate Dean, Inter-Faculty and Graduate Affairs. Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee chaired by Dr. Margaret Rand. Committee recommendations are then forwarded to the OSOTF Awards Committee (Faculty of Medicine). Three applications were received for this competition. Unfortunately, two of the applications were ineligible. This year’s recipient was Nesime Askin, PhD candidate, Department of Physiology.

Ontario Graduate School Science and Technology (OGSST) The OGSST program is designed to encourage excellence in graduate studies in science and technology. The program is supported through funds provided by the Ministry of Training, Colleges and Universities and by funds raised by the University of Toronto and the Heart & Stroke Foundation of Ontario. To be awarded to graduate students at the University of Toronto who are pursuing cardiovascular/stroke research. Students must have maintained an overall A- average over the last two years of study at the post-secondary level and exhibit research ability/potential, good communication skills and interpersonal/leadership abilities. The following students were ranked and offered an award:

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Name Degree Dept. Supervisor Mark David MSc PSL P. BackxMichael Sellan MSc PSL P. BackxSteven Gu PhD PSL S. HeximerErin Mueller PhD LMP M. HusainCindy Yip PhD BME C. SimmonsJoshua Bell PhD IMS A. BakerCharlene Reynolds PhD IMS W. McIlroyAlexandra Rowland PhD IMS S. BlackJason Wasserman PhD PSL L. Schlicter

ADVERTISING MATERIAL

The CSCP maintains and updates its web site (www.cscp.utoronto.ca). Faculty information is updated whenever we are notified of relevant changes. Collaborating departments are encouraged to provide hypertext links to the CSCP on their web site.

ACKNOWLEDGEMENTS

The Cardiovascular Sciences Collaborative Program would like to thank the following sponsors for their generous support: Heart & Stroke Foundation of Ontario, Medtronic Canada, Biovail Pharmaceuticals Canada, Bristol-Myers Squibb Company, Aventis Pharma.

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STUDENTS

Name Supervisor Degree DepartmentI. Eser Adiguzel M. Bendeck PhD LMPJenna Adleman C. Hudson MSc IMSNesime Askin C. Wittnich PhD PSLMitesh Badiwala V. Rao PhD IMSLaura Banks J. Goodman MSc EXSJessica Bronsoiler M. Hough PhD IMSGian-Marco Busato J. Goodman MSc EXSCarlo Cifelli S. Heximer PhD PSLGeoff de Couto P. Liu MSc PSLKatharine Currie J. Goodman MSc EXSTalha Farid K. Nanthakumar MSc IMSLara Gotha B. Strauss MSc IMSNazanin Hakimzadeh D. Courtman MaSc BMEChristy Hamilton M. Locke MSc EXSMelanie Henriques H. Zhang MSc PSLJudith Hoefer M. Husain MSc IMSSonya Hui M. Husain MSc PSLJessica (Jackman) Prodger V. Rao MSc IMSZobia Jawed M. Letarte MSc MBPGalina Kichigina G. Gross MSc IMSMila Kisilevsky C. Hudson MSc IMSShathiyah Kulandavelu L. Adamson PhD PSLShawn Lacombe S. Thomas MSc EXSMichael Lekas D. Stewart PhD IMSJane MacIver V. Rao PhD IMSVaska Micevski D. Stewart PhD IMS (inactive status)Anton Mihic R. Tsushima MSc PSLForough Mohammadzadeh T. Parker PhD IMSMark Moon P. Liu MSc PSLEmma O’Donnell J. Goodman PhD EXSMark Ormiston D. Courtman PhD BMEMaral Ouzounian P. Liu PhD IMSKumar Perampaladas J. Parker MSc PCLKieran Quinn H. Zhang MSc PSLTenille Ragoonanan G. Hare MSc PSLAndrew Ramadeen P. Dorian PhD PCLPatricia Rose C. Hudson PhD IMSMeghan Sauve D. Drucker MSc IMSMike Sellan P. Backx MSc PSLRohit Sheshgiri V. Rao MSc IMSAlexandra Smith H. Leong-Poi MSc IMSStjepan Soric C. Wittnich MSc PSLCarly Spragg S. Thomas MSc EXSLuka Srejic W. Hutchison MSc PSLRenee Suen D. Stewart PhD IMSLuke Tan C. Wittnich MSc PSLElissa Tepperman V. Rao MSc IMS

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Megan Thompson S. Mital MSc IMSSam Tirgari S. Heximer MSc PSLAlbert Tsui G. Hare MSc PSLLaura Voicu D. Mazer/G. Hare MSc IMSMichael Ward D. Stewart PhD IMSCindy Yip C. Simmons PhD BMEJeff Yoo R-K. Li MSc IMS

Convocated Students/Follow-Up

Kirsteen Burton, MSc, Public Health Sciences (Supervisor: Dr. G. Tomlinson): A Comparison of the Efficacy of Radiotherapy Alone Versus Ratiotherapy Combined with Embolization in the Obliteration of Brain AVMS in Canadian Patients: A Propensity Score Approach”(Radiology, McMaster University)

Adam M. Gwozdz, MSc, Institute of Medical Science (Supervisor: Dr. M. Rand): “Platelet Procoagulant Surface Expression: Persistence and Relation to Apoptosis”(Medical School – University College London, UK)

Danny Ramzy, PhD, Institute of Medical Science (Supervisor: Dr. V. Rao): “Endothelial Injury in Cardiac Transplantation: The Role of Endothelin Antagonism and Protein Kinases”(Cardiac Surgeon)

Note: Should discrepancy arise between total number of students enrolled and the number convocated, it can be accounted for students that are incomplete or terminate graduate studies.

Awards and Honors

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Jenna Adleman Vision Health Research Training Grant, Medical Sciences (Ophthalmology), York UniversityOpen Fellowship Award, University of Toronto, Medical Sciences (Ophthalmology)

Nesime Askin Gonul Anginer Award

Mitesh Badiwala Starr Medal, Faculty of Medicine, University of Toronto, 2008Edward Christie Stevens Fellowship, Faculty of Medicine, University of Toronto, 2008Joseph M. West Family Memorial Fund Award, Faculty of Medicine, University of Toronto, 2008Bigelow Book Prize, Cardiovascular Sciences Collaborative Program, University of Toronto, 2008Wellesley Surgeons OGSST, 2007Johnson & Johnson Medical Products Surgeon Scientist Program Fellowship, 2007

Carlo Cifelli Upstate New York Cardiac Electrophysiological Society – Gordon K. Moe Young Investigator Award, 2008HSRLCE Annual Cardiovascular Scientific Day Poster Competition, 3rd Place, 2008Dr. John Hepburn Award, 2008CIHR Graduate Scholarship, Doctoral Award, 2007-10

Christy Hamilton Bertha Rosenstadt Ontario Graduate Scholarship, 2007-08

Melanie Henriques NSERC Scholarship, 2008-09HSFO Studentship, 2008 (declined)OGS, 2008 (declined)Top Trainee Idea Proposal, Runner-Up, St. Michael’s Hospital Research Centre, 2007Federation of Portuguese Canadian Business and Professionals Award, 2007University of Toronto Fellowship, 2007-08HSFO John D. Schultz Science Student Scholarship, 2007-08

Sonya Hui HSRLCE Masters Studentship, 2008Department of Physiology Fellowship, University of Toronto, 2007

Shawn Lacombe Glenn H. Carter Fellowship, 2007Deans Student Leadership Award, 2007

Jane MacIver Graduate Fellowship, CIHR Strategic Training Program in Regenerative Medicine, 2007-09

Anton Mihic HSRLCE Studentship, 2007-08

Mark Moon Department of Physiology, University of Toronto Fellowship, 2007Vice-President, CSCP Student Association

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Emma O’Donnell CIHR: Institute of Gender and Health in partnership with the Ontario Women’s Health Council, Doctoral Res Award, 2008-10Glenn Carter Exercise Intervention and Disease Prevention Fellowship, University of Toronto, 2008Lorne Phenix Graduate Award, Cardiovascular Sciences Collaborative Program, University of Toronto, 2008Bertha Rosenstadt Ontario Graduate Student Award, 2007

Maral Ouzounian Canadian Institute of Health Research FellowshipWilfred G. Bigelow Prize, Terrence Donnelly Day, Canadian Cardiac Surgery Residents’ Research Day, 2008

Andrew Ramadeen University of Toronto Entrance Fellowship, 2007-08

Meghan Sauvé Banting and Best Diabetes Centre, Novo Nordisk Studentship, 2007-09Samuel Lunenfeld Research Institute Fellowship, 2007-09

Alexandra Smith Dean’s Honour List, Queen’s University, 2007

Stjepan Soric Department of Physiology Fellowship, UofTNSERC Postgraduate Scholarship

Carly Spragg Track & Field Junior Development Program, Assistant Coach, University of Toronto, 2005-07

Luka Srejic Unilever/Lipton Graduate Fellowship in Neuroscience, 2007-08Department of Physiology, Fellowship, UofT

Renée Suen Bigelow Book Prize Nomination, CSCP, UofT, 2008International Travel Award, 2007

Sam Tirgari HSRLCE Studentship, 2008

Albert Tsui CIHR Doctoral Research Award (3 yrs), 2008Best Poster Award, Critical Care Medicine, 2007A.C. Bryan Award for Best Poster, Shields Day, 2007

Laura Voicu Ontario Graduate Scholarship, 2007-08Mary H. Beatty Scholarship, 2008University of Toronto Fellowship, 2007-09

Michael Ward Finalist, Alan Wu Poster Competition, IMS Research Day, 2008Best Young Investigator Poster, Canadian Society for Clinical Investigation, Young Investigators Forum, 2007

Cindy Yip Vasculata Student Travel Award, North American Vascular Biology Organization (declined), 2007University of Toronto IBBME Fellowship, 2007-08Heart & Stroke Foundation OGSST 2007-08

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Society for Physical Regulation in Biology and Medicine Travel Award, 2008A.D. Sobel, American Society of Investigative Pathology Education Fund Scholar, 2008

PublicationsAdiguzel E, Ahmad PJ, Franco C, Bendeck MP: Collagens in atherosclerosis and its complications. Vasc Med, 2008;1-17.

Badiwala MV, Ross HJ, Rao V: An unusual and fatal complication of mechanical circulatory support with a continuous flow assist device. N Engl J Med, 2007;357:936-7.

Chan CL, Ouzounian M, Lee DS, Liu P: Diastolic heart failure: Treatment based on mechanisms. Perspect Cardiol, 2008;24(1):28-31.

Cifelli C, Rose RA, Hangjun Z, Voigtlaender-Bolz J, Bolz S-S, Backx PH, Heximer SP: RGS4 regulates parasympathetic signalling and heart rate control in the sinoatrial node. Circ Res, 2008;103(5):527-35.

Cifelli C, Boudreault L, Gong B, Bercier JP, Renaud JM: Contractile dysfunctions in KATP channel deficient mouse FDB muscle during fatigue involves excessive depolarization and Ca2+ influx through L-type Ca2+ channels. Exp Physiol, 2008;93(10):1126-38.

Gu S, Tirgari S, Heximer S: The RGS2 gene product from a candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq. Mol Pharacol, 2008;73(4):1037-43. [Epub Jan 29, 2008]

Kisilevsky M, Hudson C, Mardimae A, Wong T, Fisher J: Concentration-dependent vasoconstrictive effect of hyperoxia on hypercarbia-dilated retinal blood vessels. Microvasc Res, 2008;75:263-8

Lad VS, Rao V, Badiwala MV, Jackman J: Stem-cell therapy for ischaemic cardiomyopathy. Indian Heart J, 2007;59:B133-42.

Laurent G, Moe G, Hu X, Leong-Poi H, Connelly K, So PP, Ramadeen A, et al: Experimental studies of atrial fibrillation: comparison of two pacing models. Am J Physiol Heart Circ Physiol, 2008;294:H1206-15.

Laurent G, Moe G, Hu X, So PP, Ramadeen A, Leong-Poi H, et al: Simultaneous right atrioventricular pacing: a novel model for the study of atrial remodeling and fibrillation in the setting of heart failure. J Card Fail, 2008;14(3):254-62.

Li HL, Liu C, de Couto G, Ouzounian M, Sun M, et al: Curcumin prevents and reverses cardiac hypertrophy. J Clin Invest, 2008;118(3):879-93.

Maekawa Y, Ouzounian M, Opavsky MA, Liu PP: Connecting the missing link between dilated cardiomyopathy and viral myocarditis: virus, cytoskeleton, and innate immunity. Circulation, 2007;115(1):5-8.

19

O’Donnell E, Harvey PJ, De Souza MJ: Relationships between vascular resistance and energy deficiency, nutritional status and oxidative stress in oestrogen deficient physically active women. Clin Endocrinol, August 2008. [E-publication ahead of print]

Ouzounian M, Hassan A, Johnstone DEJ, Cox J, HowlettJ: the effect of spironolactone use on heart failure mortality: a population-based study. J Card Fail, 2007;13(3):165-9.

Ouzounian M, Lee DS, Liu PP: Cardiovascular biomarkers: a risky business. Curr Cardiovasc Rep, 2007;1:177-9.

Ramzy D, Tumiati LC, Tepperman E, Sheshgiri R, Jackman J, Badiwala MV, Rao V: Dual immunosuppression enhances vasomotor injury: interactive effect between endothelin-1 and nitric oxide bioavailability. J Thorac Cardiovasc Surg, 2008;135:938-44.

Rennie MY, Whiteley KJ, Kulandavelu S, Adamson SL, Sled JG: 3D visualization and quantification by microcomputed tomography of late gestational changes in the arterial and venous feto-placental vasculature os the mouse. Placenta, 2007;28(8-9):833-40.

Rigamonti A, LcLaren AT, Mazer CD, Nix K, Ragoonanan T, et al: Storage of strain specific rat blood limits cerebral tissue oxygen delivery during acute fluid resuscitation. Br J Anaesth, 2008;100:357-64.

Soric S, Belanger MP, Askin N, Wittnich C: Impact of femal sex hormones on liver tissue lactic acidosis during ischemia. Transplantation, 2007;84(6):763-70.

Soric S, Belanger MP, Wittnich C: A method for decontamination of animals involved in floodwater disasters. J Am Vet Med Assoc, 2008;232:364-70.

Sztajer H, Lemme A, Vilchez R, Schulz S, Geffers R, Yip CYY, Levesque CM, Cvitkovitch DG, Wagner-Dobler I: Autoinducer-2 regulated genes in streptococcus mutans UA159 and global metabolic effect of the luxS mutation. J Bacteriol, 2008;190(1):401-15.

Teoh H, Quan A, Nesher N, Lovren F, Wang G, Tirgari S, et al: Impaired endothelial function in C-reactive protein overexpressing mice. Atherosclerosis, 2008. [Epub ahead of print]

Ward MR, Stewart DJ, Kutryk MJ: Stent and Non-Stent-Based Cell Therapy for Vascular Disease. IN: Endothelial Biomedicine. (Ed: Aird WC), Cambridge University Press, 2007.

Xia F, Xie L, Mihic A, Gao X, Chen Y, Gaisano HY, Tsushima RG: Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic β-cells. Endocrinology, 2008;149(10):5136-45.

Yip CYY, Chen JH, Simmons CA: Engineering Substrate Mechanics to Regulate Cell Response. IN: Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications. (Eds. Khademhossein A, et al), Artech House Publishing, Boston, MA, 2007.

20

CSCP STUDENT ASSOCIATION SPONSORED ACTIVITIES

Circulation RoundsThe CSCP Student Association organizes and runs this event which highlights the diverse nature of research carried out by our faculty. These academic rounds rotate through the various research sites at the University of Toronto and each event is hosted by a faculty member where their research focus is the topic of the day. The goal of this event is to provide graduate students, post-doctoral fellows, research associates, undergraduates and project/summer students with the chance to develop an appreciation of the vast range of excellent research being conducted in our widespread community.

The first Circulation Rounds for the 2007-2008 academic year was given by Dr. Steffen-Sebastian Bolz where he talked on “Light and Shadow - The Effects of Sphingosine-1-Phosphate (S1P) in Terminal Arteries”. Dr. Bolz’ primary research interests lie in understanding the mechanisms that control smooth muscle cell tone in terminal arteries, which is of considerable importance, as it directly relates to the regulation of systemic blood pressure and tissue perfusion. His lecture focused on the mechanisms of blood pressure regulation by sphingosine-1-phosphate (S1P) in terminal arteries. Dr. Bolz previously identified the S1P signaling pathway as a prominent regulator of vascular tone, and he currently investigates the role of this pathway in several types of terminal arteries, including those isolated from skeletal muscle, the mesentery, the cerebral circulation, and the inner ear. Dr. Bolz is an intriguing and extremely entertaining speaker. It brought about plenty of discussion among the attendees, who were particularly curious about the potential clinical applications of targeting the S1P pathways.

The second speaker was Dr. Bradley Strauss, the Reichmann Research Chair at the University of Toronto and Sunnybrook Health Sciences Centre. As an interventional cardiologist, Dr. Strauss’ research interests lie in the field of vascular biology and include chronic total occlusions, restenosis, smooth muscle cell function, and experimental arterial response to injury. The seminar, entitled “Researching Chronic Total Occlusions: Shedding Light on a Dark Place”, began with an introduction to the practice of interventional cardiology and the difficulties that many cardiologists face due to the limitations of current 2D imaging. Consequently, novel coronary imaging techniques designed in response to this problem were described. The seminar also included a discussion of Dr. Strauss’ research, including angiogenic therapy and the use of collagenases to help treat patients with luminal occlusions. Many of the attendees enjoyed the clinical relevance of the seminar.

The third speaker was Dr. Scott Heximer, Assistant Professor and Tier II Canada Research Chair in Cardiovascular Pathology, where he talked on “Mind the GAP: The Role of RGS Proteins in the Control of Cardiovascular Pathology”. Dr. Heximer’s research focuses on the mechanisms by which cardiovascular tissues regulate hetero-trimeric G-protein signaling. His talk defined the functions of an important class of G-protein regulatory proteins, called RGS proteins, in the cardiovascular system. Dr. Heximer began by giving an overview of RGS proteins and their general function as negative modulators of G-protein activity. He then discussed his lab’s work elucidating the molecular mechanisms and cardiovascular implications of different RGS proteins through the use of gene knock-outs and physiological measures. Specifically, the Heximer lab has discovered a role for RGS2 in the control of blood pressure and vasoconstriction, RGS4 in parasympathetic signaling and heart rate control and hopes to clarify the cardiovascular role of RGS5. The seminar and following discussion were well-attended and received.

21

FACULTY

Faculty are divided into 3 categories (Full, Associate, Affiliate). Details on faculty research interests and contact information are available on the web site. Departmental affiliations listed are those within the CSCP.

Name Departmental Affiliation(s) LocationFullLee Adamson BME/IMS/PSL Mount Sinai HospitalKhosrow Adeli LMP Hospital for Sick ChildrenPeter Backx Medicine/PSL UofT – FitzGerald Bldg.Jaques Belik IMS/PSL Hospital for Sick ChildrenMichelle Bendeck LMP/Medicine UofT – MSBSandra Black IMS Sunnybrook Health CentreDouglas Bradley IMS/Medicine Toronto General HospitalDina Brooks REH UofT – Rehabilitation

ScienceJohn Coles IMS/Surgery Hospital for Sick ChildrenPhilip Connelly LMP/Medicine St. Michael’s HospitalDavid Courtman BME/Surgery St. Michael’s HospitalPaul Dorian IMS/Medicine/PCL St. Michael’s HospitalDaniel Drucker IMS/LMP Mount Sinai HospitalC. Ross Ethier BME UofT – Mechanical

EngineeringJohn Flanagan IMS Toronto Western HospitalJohn S. Floras IMS/Medicine Mount Sinai HospitalChristopher Forrest IMS/Surgery Hospital for Sick ChildrenStephen Fremes IMS/Surgery Sunnybrook Health CentreEser Fuller-Thomson Social Work UofTAdria Giacca PSL UofT - MSBJack M. Goodman EXS UofT - Physical Ed & HealthLen S. Goodman EXS Def & Civil Inst Environ MedAvrum I. Gotlieb LMP Toronto General HospitalAleksander Hinek IMS/LMP Hospital for Sick ChildrenDavid Hampson Pharmaceutical Science UofT – PharmacyMargaret Hough IMS Sunnybrook Health CentreChris Hudson IMS Toronto Western HospitalMansoor Husain IMS/LMP/Medicine Toronto General HospitalK. Wayne Johnston BME/IMS/Surgery Toronto General HospitalPeter G. Kalman IMS/Surgery CommunityFred Keeley LMP Hospital for Sick ChildrenB. Lowell Langille LMP Toronto General HospitalMichelle Letarte MBP Hospital for Sick ChildrenGary F. Lewis IMS/Medicine Toronto General HospitalRen-Ke Li IMS/LMP/Surgery Toronto General HospitalPeter Liu IMS/Medicine Toronto General HospitalMarius Locke EXS/CHL UofT – Physical Ed & HealthPeter McLaughlin IMS/Medicine Toronto General HospitalAlan Moody BME/IMS Sunnybrook Health CentreDavid Naylor IMS/Medicine/CHL/Surgery UofT – MSB

22

Heyu Ni LMP St. Michael’s HospitalPeter O’Brien PHM UofT - PharmacyJohn Parker IMS/Medicine Mount Sinai HospitalTom Parker IMS/Medicine Toronto General HospitalMargaret Rand IMS/LMP Hospital for Sick ChildrenVivek Rao IMS/Surgery Toronto General HospitalMichael Sefton BME UofT – Wallberg Bldg.Craig Simmons BME UofT – Mechanical

EngineeringArthur S. Slutsky IMS/Medicine/Surgery Mount Sinai HospitalDavid Steinman BME UofT – Wallberg Bldg.Donna E. Stewart Anesthesia/IMS/Surgery/Medicine Toronto General HospitalDuncan Stewart IMS/LMP/Medicine St. Michael’s HospitalBradley Strauss LMP/Medicine St. Michael’s HospitalHoward Tenenbaum Dentistry UofT - DentistryScott G. Thomas EXS/PSL UofT – Physical Ed & HealthJack Tu HPME Sunnybrook Health CentreRobert Wald IMS/Medicine Mount Sinai HospitalRichard D. Weisel IMS/Surgery Toronto General HospitalPeter Wells PHM UofT - PharmacyGregory Wilson IMS/LMP/PSL/Surgery Toronto General HospitalCarin Wittnich IMS/PSL/Surgery UofT - MSBGraham Wright MBP Sunnybrook Health CentreShirley Wu PHM UofT - PharmacyBurton Yang LMP Sunnybrook Health CentreTerry Yau IMS/Surgery Toronto General HospitalErik L. Yeo IMS/Medicine Toronto General HospitalYeni Yücel LMP St. Michael’s HospitalHaibo Zhang IMS/PSL St. Michael’s Hospital

AssociateJoel Fisher Anesthesia Toronto General HospitalGil Gross IMS Hospital for Sick ChildrenGregory Hare PSL St. Michael’s HospitalScott Heximer PSL UofT - MSBWilliam Hutchison PSL Toronto Western HospitalJane Irvine CHL Toronto General HospitalHoward Leong-Poi IMS St. Michael’s HospitalValery Leytin LMP St. Michael’s HospitalTom Lindsay IMS/Surgery Toronto General HospitalSeema Mital IMS Hospital for Sick ChildrenKumar Nanthakumar IMS Toronto General HospitalSteffen-Sebastian Bolz PSL UofT - MSB

AffiliateJagdish Butany LMP/Medicine Toronto General HospitalGideon Cohen Surgery Sunnybrook Health CentreChris M. Feindel Surgery Toronto General HospitalDavid Mazer Anesthesia/IMS St. Michael’s HospitalPatricia Murphy Anesthesia Toronto General Hospital

23

PEER REVIEWED FUNDING

Name Agency TitleAdamson, L CIHR-Maintenance

CIHR-GroupCIHR-Equip /MaintenanceCIHR-Operating

CIHR-Operating

CIHR-Resource

CIHR-Operating

CIHR-Healthy Pregnancy ProgramCIHR-GroupHSFC-Grant-in-Aid

Maintenance of the advanced bioimaging centre (2006-11)Development and fetal health (2005-10)Cardiovascular phenotyping in embryonic and newborn mice (2005-10)Generation and physiological analysis of genome-wide mutations in mice (2004-09)Cardiovascular phenotyping in embryonic and newborn mice (2004-08)Canadian mouse mutant repository: a core resource for mouse models of human disease (2006-11)A murine model to investigate the mechanisms underlying DOHαD (2006-09)Fetal growth restriction: mechanisms and outcomes (2005-10)

Centre for modeling human disease (2004-09)Three dimensional quantification of the placenta vascular tree: relationship with normal and abnormal fetal growth and hemodynamics (2006-08)

Belik, J CIHR-Operating

CIHR-GroupHSFO-Operating

Airway modulation of pulmonary vascular tone during development and following pulmonary hypertension (2004-09)Group in lung development (2004-09)Endothelial eNOS uncoupling and role of BMP-9 in the regulation of pulmonary vascular tone during development and following pulmonary hypertension (2007-09)

Black, SE HSFO

CIHR

HSFO

NIH

HSFO

HSFC

CIHR

CIHR

NIHCIHRAlzheimer Society of CanadaOntario Stroke System

Ontario Mental Health FoundationPSI Foundation

Neuropsychological profiles and neuroanatomic correlates of limb apraxia (2007-12)The language impairment in progressive aphasia: a longitudinal neuropsychological and imaging study (2007-12)Role of cytokine-serotonin interactions in post-stroke depression and cognitive symptoms (2007-10)Validation of the NINDS VCI neuropsychological protocols (2007-10)Role of cytokine-serotonin interactions in post-stroke depression (2006-08In vivo characterization of subcortical vascular cognitive impairment using advanced high field MR techniques (2005-08)In vivo brain mapping in the dementias: a longitudinal brain-behaviour study with a focus on cerebrovascular disease (2003-08)A multi-centre, blinded, randomized, controlled trial comparing different regimens of the antibiotics doxycycline and rifampin for treatment of Alzheimer’s Disease (DARAD) (2006-10)ADNI (Alzheimer’s Disease Neuroimaging Initiative) (2005-09)Canadian Alzheimer’s Disease quality of life study (2002-09)Assessing driving performance in persons with mild cognitive impairment and mild dementia (2008-10)Infrastructure revision of the collaborative affect, cognition and behavior database tool (ABC’s) (2007-08)Theory of mind in Alzheimer’s Disease and frontotemporal dementia (2007-09)Relationship between neuropsychological deficits and hippocampal volume in coronary artery disease (2007-09)

24

Name Agency TitleBlack, SE (cont’d)

Bell Labs, UofT

CIHR

CIHR

HSFO

NSERC / CIHR

CIHR

Alzheimer Soc Canada

Can Stroke Network

CIHR Maintenance/ equipment grantCIHR Program Grant

NCR Can Stroke Network

Context-aware mobile devices and wireless services as cognitive aids for senior citizens (2007-08)Determinants of safe mobility in the elderly who use assistive mobility devices (2007-08)Parietal and temporal contributions to the neglect syndrome (2006-09)Feasibility and effects of cardiac rehabilitation for individuals after stroke (2006-09)Personal therapist: a smart ambulatory monitoring system to facilitate recovery following stroke (2006-09)Early exercise intervention after stroke: improving cardiovascular health, functional capacity and sensorimotor control (2006-09)Function and behavioural and psychological symptoms of frontotemporal dementia (2006-08)Stroke Canada optimization of rehabilitation by evidence – implementation trial (SCORE-IT) (2006-08)Centre for research using magnetic resonance (2005-10)

Brain and aging group at the Rotman Research Institute (2003-08)Canadian Stroke Registry (2001-08)

Brooks, D HSFOOnt. Lung Assoc.CIHR

CIHR

CIHR

Physicians Services Inc.

Physiotherapy Fdnt/Can. Lung Assoc.Start-up AwardCIHR

Ont Research Fund/Can Fdtn of Innovation

CIHR

Lung Association

Ontario Lung Assoc.Ontario Lung Assoc.

Cardiac rehabilitation for individuals after stroke (2006-09)Evidence-based suctioning: A systematic review (2007-08)The personal therapist: A smart ambulatory monitoring system to facilitate recovery following stroke (2006-09)Timely access and seamless transitions in rural palliative/end of life care (2006-11)Improving sensorimotor recovery, aerobic capacity and functional walking (2006-09)Investigating the relationships between measures of functional exercise capacity, symptoms and physical activity during daily life in subjects with COPD (2007-09)Effects of course layout on 6-minute walk distance (6MWD) in COPD: A prospective within subject study (2007-08)Research aimed at muscle performance (2008-11)Theatre-based intervention for increasing exercise participation by older adults requiring chronic hemodialysis (2007-08)Cardiopulmonary rehabilitation laboratory: Infrastructure to generate knowledge to maximize daily function in individuals with chronic obstructive pulmonary disease (2007-08)Concensus Meeting: Quality indicators for end of life care in COPD (2008)Unsupported arm exercise and breathing strategies in patients with COPD (2008-09)Survey of suctioning practice in Ontario (2008-09)The six-minute walk test: Responses in healthy Canadians aged 45-85 years (2008-09)

Butany, J CIHR Team GrantNSERC/CIHR/CHRP

Chronic total occlusion (2006-09)Local tissue changes in dilated ascending aortas (2005-08)

Connelly, P HSFO Molecular mechanisms for oxidation of high density lipoproteins (2006-08)

25

Name Agency TitleConnelly, P (cont’d)

HSFO

CIHR

Can Diabetes Assoc.

Pfizer

Comparative studies of paraoxonase 1 and paraoxonase 3 (2005-08)Role of adipokines and inflammatory proteins in the early pathophysiology of type 2 diabetes in women with a history of gestational diabetes (2007-12)Role of adipokines and inflammatory proteins in the early pathophysiology of type 2 diabetes in women with a history of gestational diabetes (2007-10)Nitrosation of apolipoprotein A1 (2007)

Dorian, P HSFC

HSFC

CIHRCan Stroke Network

Drivers with implantable cardioverter defibrillators (ICDs) in Ontario: database linkage feasibility – a pilot project (2008-10)Improving teaching of basic life support: a randomized pilot study of real-time feedback in CPR performance (2008-09)Centre for global clinical trials – CANNeCTIN (2008-10)Event monitoring belt for recording atrial fibrillation after a cerebral ischemic event: a RCT (EMBRACE) (2008-10)

Fisher, JA CIHR Multi-modal imaging studies of the relationship between age, physical activity level, cerebral physiology, and cognitive performance (2007-11)

Floras, J CIHRHSFOHSFO-Program

CIHR

CIHRHSFO

CIHR

CIHR Tier I Chair (2004- )Career investigator Award (2001-09)Multidisciplinary group for the investigation and therapy of human cardiovascular disease (2003-08)Cardiovascular, autonomic and neurohormonal impact of nocturnal hemodialysis (2005-10)Pathophysiology sleep apnea in heart & renal failure (2007-12)Effects of continuous positive airway pressure on myocardial energetics and sympathetic nerve function in patients with heart failure and obstructive sleep apnea (2005-08)Effects of HMG-co-A reductase inhibitor therapy on neural control of the heart and circulation in human heart failure (2007-08)

Giacca, A HSFCHSFCCDACIHR

CIHR

CIHR

NSERC

NSERC

NSERC

Anti-atherogenic effect of insulin (2005-08)Vasculoprotectie effect of insuln in vivo (2008-11)Mechanisms of fat-induced hepatic insulin resistance (2006-08)Interaction between lipotoxicity and glucotoxicity on glucose stimulated insulin secretion (2004-07)Glucose toxicity: prevention of complications and preservation of beta cell function (2002-07)Mechanisms of oxidative stree-mediated beta cell glucotoxicity and lipotoxicity in vivo (2007-12)Investigation of the biological effects of the polyphenol resveratrol on skeletal muscle glucose transport (2004-07)MEMS-based closed loop drug delivery devices integrating stimulus-responsive nanohydrogels: design, fabrication, and testing (2007-10)Investigation of the biological effects of the polyphenol resveratrol on insulin producing and insulin target tissues (2007-09)

Gotlieb, AI HSFOCIHR

HSFO

Cell biology of atherosclerosis (2005-10)The endothelium in atherogenesis: Influences of hemodynamic stresses (2007-12)Cell biology of heart valve interstitial cells (2007-09)

26

Name Agency TitleGramolini, A HSFO

CIHR

Can Fdtn for Innovation

Molecular basis of PLN regulation and function in cardiac muscle (2006-08)Molecular regulation and function of ryanodine receptors (RyR1) in skeletal muscle (2007-12)Cardiovascular proteomics & molecular theapeutics (2007-12)

Gross G CIHR

HSFOHSFO

CIHR

HFSO

CIHR

Characterization of circulating effectors and temporal profiling of remote ischaemic preconditioning (2006-09)Ventricular repolarization in complete heart block (2004-07)Contractile and electrophysiologic adaptations to constrained heart rate conditions (2006-08)Molecular expression and physiology in developing atrioventricular nodal cells (2006-09)Ventricular repolarization in bradycardic electrical remodeling (2007-10)Contractile adaptations to constrained heart rate conditions (2008-12)

Hinek, A CIHR-Operating

HSFO-Operating

Human Matrix Sciences

HSFCCIHR-GroupHSFC-Operating

HSFC-Operating

Elastin and elastin receptor in pathobiology of cardiovascular disease (2006-11)Elastin and elastin receptor in control of cellular proliferation (2003-08)Comparison of biological effects of different preparations of elastin-derived peptides on skin fibroblasts (2004-10)Career Investigator Award (2004-07)Pathobiology of intimal plaquesAldosterone receptor and non-receptor based mechanism of repair and remodeling following cardiac injury (2005-08)Elastin and elastin receptor as crucial factors modulating cellular functions in cardiovascular development and disease (2008-13)

Hudson, C Glaucoma Res. Society

CIHR-Operating

CIHR-Operating

Retinal vascular reactivity in response to isoxic hypercapnia in primary open-angle glaucoma (2007-09)Sight-threatening retinal complications in type 2 diabetes (2005-10)Vascular reactivity in primary open angle glaucoma (2006-10)

Husain, M HSFO-Operating

CIHR- Operating

CIHR-Operating

HSFO-Operating

CIHR-OperatingHSFO-Operating

CIHR-Operating

HSFO-GroupCIHR-GroupHSFO

CIHR

Role of glucagons-like peptides in cardiac health and disease (2006-09)c-Myb-dependent vascular smooth muscle cell proliferation (2004-09)The role of plasma membrane Ca2+-ATPase isoforms in vascular smooth muscle cell biology (2003-08)Controlling bioreactor condition to optimize regenerative potential of cardiomyocytes (2007-09)Pathophysiological relevance of endothelin-1 (2005-10)Targeted over-expression of inducible NO synthase: relevance for the pathogenesis of cardiovascular disease (2005-08)Role of ACE2 in the regulation of cardiac and vascular function (2003-08)Cell biology of atherosclerosis (2005-10)Determinants of host susceptibilities of heart failure (2003-08)Molecular regulation of vascular smooth muscle cell proliferation and contractility (2004-09)Development of an anti-proliferative therapeutic that disrupts CaM-cyclin E interactions (2007-08)

27

Name Agency TitleLangille, L CIHR-Operating

HSFO-OperatingHSFO-Operating

CIHR

HSFO-GroupCIHR-Group

Influence of hemodynamics on arterial endothelium (2007-12)Arterial responses to hemodynamic stresses (2007-10)Cadherins and regulation of smooth muscle cell function (2007-12)A new concept underlying the control of myometrial contractility during pregnancy (2005-10)Cell biology of atherosclerosis (2005-10)Development and fetal health (2005-10)

Letarte, M CIHR-Operating

HSF

CIHR-Operating

HSFO

United States Army

Endoglin, ALK-1 and BMPRII networks: role in vascular disorders (2005-10)Role of endoglin in the normal vasculature and in the pathology of hereditary hemorrhagic telangiectasia (2005-09)Functional characterization of androgen-altered genes with a putative role during early events in ovarian carcinogenesis (2005-09)eNOS uncoupling and role of bone morphogenetic protein in the regulation of pulmonary vascular tone during development and following pulmonary hypertension (2007-09)Characterization of hereditary serous cancer precursors in fallopian tube epithelium (2006-09)

Leytin, V HSFC

CIHR

Platelet apoptosis induced by chemical agonists and shear stresses (2005-08)Use of normal physiologic inhibitors of matrix metallopro-tein-ases to improve viability and function of platelet concentrates (2006-09)

Li, R-K CIHR

Ont Min Agriculture and Food/Univ. of Guelph Food Res. ProgramCIHR

CIHR

CIHRHSFO

HSFO

HSFO

Can Fdnt for InnovationCIHR

Autologous tissue-engineered grafts for congenital heart surgery (2003-08)Functionality of resistant starch and bioactive peptides in preventing chronic diseases and promoting gut functions in studies with the pig model (2004-08)The interplay of recruited stem cells and the matrix after myocardial infarction: shifting balance toward repair (2004-09)The cardiac regeneration project: quantitative cell tracking and response for cardiac regenerative approaches (CARE project) (2006-11)Inflammation, infection, trauma and repair cluster (2006-13)Matrix modulation is required to restore cardiac function after cell therapy (2007-09)Peptide modified photocrosslinkable chitosan for cell therapy in myocardial infarction (2007-10)Restoration of cardiac function: cellular regeneration and matrix reconstruction (2007-11)The Regenerative Medicine Project (REMEDI) (2007-12)An angiogenic progenitor cell niche in the uterus: potential implications for cell therapy (2008-13)

Lindsay, T Physicians’ Services Inc.

Complement activation following ruptured abdominal aortic aneurysm: combining human observation with animal experimentation to establish a framework for human therapy (2007-09)

Mazer, CD PSI

HSFO

High fidelity simulation versus traditional didactic seminars for teaching trainees separation from cardiopulmonary bypass (2006-08)Unravelling the black box of adverse events in cardiac surgery (2006-09)

28

Name Agency TitleMazer, CD (cont’d)

PSI Foundation

AO Research Fund

CIHR

CIHR

Can Anesth Society

Can Blood ServicesSoc Cardiovasc Anesth

IREF

Genetic biomarkers of renal injury after cardiopulmonary bypass and anemia in the rat (2007-08)Sternal closure stability using the sternal fixation system (2007-08)Does nutrient supplementation influence cardiac function, structure and survival by altering energy metabolism? (2005-07)Blood conservation using antifibrinolytics: a randomized trial in a cardiac surgery population – the BART study (2002-08)Renal gene expression following cardiopulmonary bypass and anemia in the rat (2006-07)Transfusion triggers in cardiac surgery (2006-08)Impact of cardiopulmonary bypass and cardiac surgery on lymphocyte energetics and immune function in patients with non insulin dependent diabetes mellitus (2005-07)Clinical outcomes and predictors of prolonged length of stay in the intensive care unit after cardiac surgery. Analysis from the multicenter EPI 2 study (2006-08)

Mital, S NIH/NLHBI Pediatric Heart NetworkNIH/NLHBI Pediatric Heart NetworkResearch EndowmentLabatt Family Heart Ctr Innovation FundsLabatt Family Heart Ctr Innovation Funds

Genetic polymorphisms in pediatric cardiomyopathy (2006-11)

Single ventricle reconstruction-2 trial (2006-11)

Developmental biology and congenital heart research (2007)Genetics of heart disease in children (2007-10)

VEGF signaling in HLHS (2007-2008)

Moody, A CIHR-TeamMRICIHR-OperatingCIHR-TeamCIHR-Operating

Pfizer Global Res/Dev

CIHR

CIHR

Ont Ministry of Health

Canadian atherosclerosis imaging network (CAIN) (2008-13)Imaging for cardiovascular therapeutics (2008-13)Magnetic resonance imaging for ischemia (2005-10)CIHR team in occlusive vascular disease (2007-09)The development of an in vivo animal model and non-invasive high resolution imaging techniques for the study of atherosclerotic intraplaque haemorrhage (2006-09)A methodology study to investigate MRDTI for assessment of lesion response to standard treatment in endometriosis (2007-09)In vivo detection of early diabetic vessel wall disease – a possible role for the RAGE-AGE RBC-Endothelial (RARE) complex at the micro- and macrovascular levels (2007-09)PROTECT: Prophylaxis for thromboenbolism in critical care trial (2005-09)The Ontario multidetector computed tomography (MDCT) coronary angiography study (OMCAS) (2006-08)

Ni, H CIHR

CIHR-Cdn Blood Services

CIHR/Cdn Blood Services

Pathogenesis of fetal and neonatal alloimmune thrombo-cytopenia and mechanism of action of IVIG in a novel mouse model (2007-11)Investigation of pathogenesis of immune thrombocytopenia and efficacy and mechanism of action of intravenous IgG (OVOG) (2006-09)Mechanism of action of IVIG in a murine model of fetal and neonatal alloimmune thrombocytopenia: role of neonatal Fc receptor (FcRn) (2007-09)

29

Name Agency TitleParker, T CIHR

CIHR

HSFO

CIHR

CIHR-Team

HSFC

Role of S100B-dependent pathways in the cardiac response to disease (2005-10)EF-hand proteins, S100A1 and S100A6, in cardiovascular pathophysiology (2007-09)EF-hand proteins, S100A1 and S100A6, in cardiovascular pathophysiology (2008-13)Coordinated original research in elucidation of mechanisms in heart failure (CORE-CHF) (2003-08)Dysfunctional endothelial cell repair in diabetes: pathogenetic mechanisms and regenerative strategies (2006-11)Endothelial progenitor cell modification to improve left ventricular function post myocardial infarction (2008-11)

Rand, M HSFO Procoagulant surface of activated platelets: Persistence in vivo and in vitro

Sefton, M ORDCF

CIHR

NSERCCIHRCIHRCIHR STIHR ProgramCFINIH

CIHR

Establishment of an advanced reconstructive tissue engineering centre (2003-09)Tissue engineering: Immune response and vascularisation (2004-07)Tissue engineering (2008-13)Training program in regenerative medicine (2002-08)Quantum dot-based biomolecular imaging (2005-10)The cardiac regeneration (CARE) project (2006-11)The regenerative medicine (REMEDI) project (2006-11)Modular tissue engineering components for vascularized 3-D constructs (2007-10)Modular tissue engineering for islet transplantation (2007-08)

Simmons, C NSERC-CIHR

NSERC-DiscoveryCFI-ORFCRCOnt Early ResearcherAAOF CenterHSFHSFNSERC RTI

NSERC RTI

CIHR

Ont. Res Comm Prog

Investigation of mesenchymal progenitor cell response to mechanobiological stimuli using a novel MEMS-based array platform (2006-09)Heart valve cell biomechanics and mechanobiology (2006-11)IMchanobiology lab (2006-09)Canadian Research Chair in mechanobiology (2006-11)Tissue engineered heart valves (2006-11)3D model to study orthodontic tooth movement (2007-08)ECM biomechanics in aortic valve sclerosis (2007-08)Myofibroblast mechanoregulation (2007-10)Non-contact plotter for precise patterning of proteins on novel microdevices (2008-09)A polscope for non-invasive visualization of meiotic spindle (2008-09)Multi-user equipment for molecular and cell biological analysis (2006-11)Bioreactor for urinary bladder regeneration (2008-09)

Slutsky, AS CIHR

CIHR/HSFC

Biotrauma: mechanisms of lung injury and distal organ dysfunction (2004-09)Clinical research consortium to improve resuscitation outcomes: from bench to bedside to curbside (2004-09)

Stewart, DE Ont Min Health Long and Term CareCIHR

CIHR

Improving health and promoting equity for the women of Ontario (2006-09)International comparisons of the perinatal health and care of migrant women (2006-08)Cardiovascular secondary prevention for vulnerable populations: an interdisciplinary approach to improving access to services and outcomes (2006-11)

30

Name Agency TitleStewart, DE (cont’d)

CIHR

CIHR

CIHR

Int Dev Res Centre

Public Health AgencyCIHR

Can Diabetes Assoc.CIHRCIHR

CIHR

CIHR

Assessing the feasibility to measure and compare gender-sensitive mental health indicators in Peru, Colombia and Canada (2006-08)Neurochemical aspects of depression in women: monoamine oxidase A in the postpartum period (2007-10)Measuring and understanding gender equity in access to care (2006-09)Political violence, natural disasters and mental health outcomes: developing innovative health policies and interventions (2007-11)Health indicator research (2006-08)Comparing paper vs electronic transmission of cardiac rehabilitation summaries to primary care physicians: a multi-site multi-method study of information flow and content (the CR2DoC study) (2008-11)Food insecurity in Canadians with diabetes mellitus (2007-08)Mood changes and daily life (2005-08)The childbearing health and related service needs of newcomers (CHARSNN) (2004-08)An RCT to evaluate the effectiveness of peer support for PPD (2004-08)Contribution of patient and physician factors to cardiac rehabilitation referral and participation: a prospective, multi-level study (2005-08)

Tu, J HSFO

HSFO

CIHRCIHRCIHR

CIHR

CIHRCIHR

CIHRMinistry of HealthCIHRHSFO

CIHR

Drivers with implantable cardioverter defibrillators (ICDs) in Ontario: database linkage feasibility: a pilot project (2008-10)Indicators of quality stroke care associated with clinical outcomes (2008-10)Emergent care and outcomes of acute heart failure (2008-10)Statistical methods for health services research (2008-10)A population-based analysis of the effectiveness and adverse effects of medications in patients with atrial fibrillation (2007-10)Evaluating and improving the quality of care and outcomes of percutaneous coronary interventions in Canada (2007-09)Canada Research Chair in Health Services Tier 1 (2007-13)Care gaps among high-risk cardiovascular patients: Evaluating the inappropriateness and clinical significance of the “treatment –risk paradox” (2006-09)Access to quality cardiac care (2006-11)The Ontario implantable cardioverter defibrillator (2006-11)Canada Research Chair in Health Services Tier 2 (2006-08)Improving the quality of acute myocardial infarction care in Canada (2005-10)Gender and sex determinants of cardiovascular disease: from bench to beyond (2004-09)

Watt-Watson, J

CIHR

CAN

CAN

CIHR/HSFC

Prevalence and predictors of non-ischemic chest pain following successful percutaneous coronary intervention (2007-08)How do providers manage pain in hip fracture patients after they are educated about the RNAO best practice guidelines (2007-08)Concept analysis and feasibility study of an adapted non-verbal pain assessment tool (2007-08)Training program for cardiovascular nurse scientists (2003-09)

31

Name Agency TitleWeisel, RD HSF

CIHR

CFI & ORSHSF

Cardiac regeneration by cell transplantation (2006-09)The cardiac regeneration project: Quantitative cell tracking and response for cardiac regenerative approaches (CARE project) (2007-11)The regenerative medicine (REMEDI) project (2006-10)Cardiac regeneration: improving response to injury(2007-10)

Wells, PG Methanol Fdtn (USA)CIHR

CIHR

NIH

Molecular basis of methanol developmental toxicity (2006-10)Toxicology of drugs bioactivated to a reactive intermediate (2007-12)Free radical determinants of meurodegenerative diseases (2005-10)Fetal DNA oxidation and repair in neurodegeneration (2006-08)

Wittnich, C HSFOHSFO

Oxygen stress in newborn hearts (2003-07)Impact of gender on myocardial pathology & ischemia reperfusion (2004-08)

Wright, GA CIHR-OperatingOnt Innovation TrustCIHR

CIHRCIHRCIHR-Operating

CIHRCdn Fdtn InnovationCdn Fdtn InnovationOnt Research FundOnt Research Com- mercialization ProgramCIHR-Operating

NSERC

Magnetic resonance imaging ischemic heart disease (2003-10)Imaging research centre for cardiac intervention (2002-08)Microvessel formation in chronic total occlusions: pathophysiology and role in successful guide-wire crossing (2005-08)Centre for research using magnetic resonance (2005-10)Magnetic resonance imaging for ischemia (2005-10)Development of an in vivo animal model and non-invasive high resolution imaging techniques for the study of atherosclerotic intraplaque haemorrhage (2006-09)CIHR team in occlusive vascular disease (2007-10)Biomedical multimodality hybrid imaging (2007-11)Regenerative medicine project (REMEDI) (2007-11)Imaging for cardiovascular therapeutics (2007-13)Bi-directional 3D assistive tool for medical image acquisition and visualization (2008)Therapeutic strategies for chronic total occlusion revascularization (2008-11)Forward-viewing Doppler optical coherence tomography with artifical muscle actuation for interventional intravascular imaging (2006-09)

Wu, S CHRP-OperatingNSERCBioDiscovery Toronto

(2007-10)(2008-13)(2008)

Yang, B CIHRHSFO

IGH Mid-Career Award – denied (2006-11)Roles of miR-17-5p in endothelial wounding healing and angiogenesis (2008-11)

Yau, T CIHR Predictors of massive blood loss in cardiac surgery: value of intraoperative coagulation testing (2006-08)

Yücel, YH Glaucoma Res Society

Int Glaucoma ReviewCIHR

Can Glaucoma Clinical Research CouncilGuacoma Res Society

A new lymphatic outflow pathway as a novel target for glaucoma treatment (2008-09)Best Article Award 2006 (2007-08)An outflow perspective on aqueous humor exit from the eye: implications for glaucoma (2007-08)Multifocal ERG in patients with glaucoma (2007-08)

Can a vaccine for multiple sclerosis prevent glaucoma injury in the central visual system? (2007-08)

32

AWARDS AND HONORS

NAME HONORS AND AWARDSBlack, SE - Practice-based Research Award, Sunnybrook Health Sciences Centre (2007-09)

- Deborah Ivy Christiani Brill Chair in Neurology, Sunnybrook Foundation, UofT- SRI Merit Pool Award, Sunnybrook Research Institute

Brooks, D - Canada Research Chair – Tier 2 (2007-12)Butany, J - President, International Society for Cardiovascular Pathology (2007-09)

- President, Canadian Association of Pathologists (2006-09)- Invited Guest Co-Editor, Seminars in Diagnostic Pathology: Issue on Cardiac Tumors. Published (2008)

Gotlieb, AI - William Boyd Lectureship, Canadian Association of PathologyGramolini, A - Canada Research Chair Tier 2 (2007-12)

- New Investigator Award, Heart & Stroke Foundation of Canada (2006-11)Gross, G - Schwartz-Reisman Visiting SickKids Scholarship, Hospital for Sick Children, 2008Hudson, C - Promoted to Professor (both UW and UofT)Husain, M - Career Investigator Award, Heart & Stroke Foundation of Ontario (2004-09)Leytin, V - Associate Professor, Dept. of Laboratory Medicine and Pathobiology, UofTLi, R-K - Canada Research Chair in Cardiac Regeneration, Tier 1

- Career Investigator Award, HSFC- Vincenzo Panagia Distinguished Lecture Award

Lindsay, T - Promotion to Professor, University of Toronto- Wightman Berris Academy, Individual Teaching Award, 2008

Mital, S - Roma and Marvin Auerbach Professor of developmental biology and congenital heart disease research, 2007

Rand, M - Member, Board of Directors, Heart and Stroke Foundation of OntarioSefton, MV - Killam Prize, Canada Council for the Arts

- Founders Award, Society for Biomaterials, USA- Hall of Distinction, UofT, Faculty of Applied Science & Engineering

Stewart, DE - CIHR/Royal Society of Canada Visiting Women Scientist to Japan (WiSET)- Co-Chair, International Committee to Review Abuses of Psychiatry, World Psychiatric Association (2006-12)- Inaugural Honorary Fellow, Canadian Psychiatric Association (2006-Present)- Elected to AOA, Faculty Member (2006-Present)- Institutional Advisory Board of CIHR Institute of Gender and Health (2006-09)- Senior Advisor to World Health Organization on Women’s Mental Health (2007-Present)- Commission on the Status of Women of the United Nationa (2005-Present)- University Professor (2004-Present)- President, International Association of Women’s Mental Health (2004-08)

Wittnich, C - Excellence in undergraduate teaching, Life Sciences Award, UofT, 2008Wu, XY - Provincial Innovation Award, Ontario Research & Commercialization Program, 2008Yücel, YH - American Academy of Opthalmology. Tau Pathology in Human Glaucomas, Top 10

paper, 2007- American Glaucoma Society. Tau Pathology in Human Glaucomas, Top 10 paper, 2007- Nominee, Lewis Rudin Glaucoma Prize, 2007- Global Association of International Glaucoma Societies Award, 2007

33

PUBLICATIONSAbdekhodaie MJ, Wu XY: Drug release from ion-exchange microspheres: mathematical modeling and experimental verification. Biomaterials, 2008;29:1654-63. (Web publication: doi:10.1016/j.biomaterials.2007.11.044)

Abdel-Malek N, Chiarelli AM, Sloan M, Stewart DE, Mai V, Howlett RI: Influence of physician and patient characteristics on adherence to breast cancer screening recommendations. Eur J Cancer Prev, 2008;17(1):48-53.

Ahmad F, Hogg-Johnson S, Stewart DE, Levinson W: Violence involving intimate partners: prevalence in Canadian family practice. Can Fam Physician, 2007;53:460-8.

Ahmad K, Dorian P: Drug-induced QT prolongation and proarrhythmia: An inevitable link? Europace, 2007;9:iv16-22.

Al-Attar SA, Pollex RL, Ban MR, Young TK,… Connelly PW, Huff MW, Hegele RA: Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. Cardiovasc Diabetol, 2008;7:5. doi:10.1186/1475-2840-7-5

Al-Kwifi O, Wright GA: Comparing the limits of 3D contrast enhanced MRA at 1.5 and 3T to achieve high spatial resolution. Neurosci Imaging, 2007;2(2):91-9.

Al-Kwifi O, Wright GA: Rapid estimation of motion blur for real-time optimization of high resolution imaging. Neurosci Imaging, 2007;2(2):101-6.

Altaf N, Beech A, Goode SD, Gladman JR, Moody AR, Auer DP, Macsweeney ST: Carotid intraplaque hemorrhage detected by magnetic resonance imaging predicts embolization during carotid endarterectomy. J Vasc Surg, 2007;46(1):31-6.

Altaf N, Daniels L, Morgan PS, Auer D, MacSweeney ST, Moody AR, Gladman JR: Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events. J Vasc Surg, 2008;47(2):337-42.

Amfilochiadis AA, Backx PH, Floras JS: Adrenomedullary catecholamine, pressor and chronotropic responses to human coagulation β-FXIIa mediated by endogenous kinins. J Hypertens, 2008;26:61-9.

Aufderheide TP, Kudenchuk PJ, Hedges JR, Nichol G, Kerber RE, Dorian P, Davis DP,… for the ROC Investigators: Resuscitation Outcomes Consortium (ROC) PRIMED cardiac arrest trial methods, Part 1: rationale and methodology for the impedance threshold device (ITD) protocol. Resuscitation, 2008;78(2):179-185.

Baker JE, Mazer CD: Anticoagulation and regional anesthesia in cardiac surgery: safety considerations. Tech Reg Anesth Pain Manag, 2008;12(1):17-25.

Baker AJ, Park E, Hare GMT, Liu E, Sikich N, Mazer CD: Effects of resuscitation fluid on neurological physiology after cerebral trauma and hemorrhage. J Trauma, 2008;64(2):348-57.

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Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M: Cardioprotective and vasodilatory actions of GLP-1 are mediated through both GLP-1 receptor-dependent and independent pathways. Circulation, 2008;117(18):2340-50. [Epub 2008 Apr 21]

Bansal V, Hill K, Dolmage TE, Brooks D, Woon LJ, Goldstein RS: Modifying track layout from straight to circular has a modest effect on the six-minute walk distance. Chest, 2008,133:1155-60.

Bardy GH, Lee KL, Mark DB, Poole JE, Toff WD, Tonkin AM, Smith W, Dorian P, et al, for the HAT Investigators: Rationale and design of the Home Automatic external defibrillator Trial (HAT). Am Heart J, 2008;155(3):445-54.

Bardy GH, Lee KL, Mark DB, Poole JE, Toff WD, Tonkin AM, Smith W, Dorian P, et al, for the HAT Investigators: Home use of automated external defibrillators for sudden cardiac arrest. N Engl J Med, 2008;358(17):1793-804.

Bauwens CL, Peerani R, Niebruegge S, Woodhouse KA, Kumacheva E, Husain M, Zandstra PW: Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories. Stem Cells, 2008 June 26. [Epub ahead of print]

Beck J, Brander L, Slutsky AS, Reilly MC, Dunn MS, Sinderby C: Non-invasive nurally adjusted ventilatory assist in rabbits with acute lung injury. Intensive Care Med, 2008;34(2):316-23.

Behrmann M, Avidan G, Gao FQ, Black S: Structural imaging reveals anatomical alterations in inferotemporal cortex in congenital prosopagnosia. Cereb Cortex, 2007;17:2354-63.

Belik J, Shehnaz D, Pan J, Grasemann H: Developmental changes in arginase expression and activity in the lung. Am J Physiol Lung Cell Mol Physiol, 2008;294:L498-504.

Bergman B, Ahmad F, Stewart DE: Work family balance, stress and salivary cortisol in men and women academic physicians. Int J Behav Med, 2008;15(1):54-61.

Bernstein D, Williams GE, Eisen H, Mital S, Wohlgemuth JG, Klingler TM, Fang KC, Kobashigawa J: Gene expression profiling distinguishes a molecular signature for grade 1B mild acute cellular rejection in cardiac allograft recipients. J Heart Lung Transplant, 2007;26(12):1270-80.

Best G, Dennis M, Hudson C, Lee R and Smit H: Optometric care of the patient with diabetes -a core document of the Canadian Association of Optometrists. Can Assoc Optometrists, 2008 (http://portal.opto.ca/committees-administration/cao-committees/diabetes-committee/).

Black SE, Doody R, Li H, McRae T, et al: Donepezil preserves cognition and global function in patients with Alzheimer Disease. Neurology, 2007;69(5):459-69

Black SE: PiB PET and cerebral amyloid angiopathy detection. J Watch Neurol, 2008, Review.

Blackmore ER, Munce SE, Weller I, Zagorski BM, Stansfeld SA, Stewart DE, Cain ED, Conwell Y: Psychosocial and clinical correlates of suicidal acts: results from a national population survey. Brit J of Psychiatry, 2008;192:279-84.

35

Blackmore ER, Stansfeld SA, Weller I, Munce SE, Zagorski BM, Stewart DE: Major depressive episodes and work stress: results from a national population survey. Am J Public Health, 2007;97:2088-93.

Blair M, Kertesz A, Davis-Faroque N, Hsiung GY, Black SE, et al: Behavioural measures in frontotemporal lobar dementia and other dementias: the utility of the frontal behavioural inventory and the neuropsychiatric inventory in a national cohort study. Dement Geriatr Cogn Disord, 2007;23(6):406-15.

Bocti C, Black S, Frank C: Management of dementia with a cerebrovascular component. Alzheimer’s and Dementia, 2007;3(4):398-403.

Bograd AJ, Mital S, Schwarzenberger JC, Mosca RS, et al: Twenty-year experience with heart transplantation for infants and children with restrictive cardiomyopathy: 1986-2006. Am J Transplant, 2008;8:201-7.

Bouchentouf M, Benabdallah BF, Bigey P, Yau TM, Tremblay JP: Vascular endothelial growth factor reduced hypoxia induced death of human myoblasts and improved their engraftment in SCID mouse muscles. Gene Ther, 2007;15:404-14.

Brander L, Slutsky AS: Invasive Mechanical Ventilation. IN: Clinical Respiratory Medicine, 3rd Edition (EDS: Albert RK, Spiro SG, Jett JR). Mosby Elsevier, Philadelphia, 2008:231-56.

Briet F, Keith ME, Leong-Poi H, Kadakia A, Aba-Alkhail K, Gilliberta JP, Stewart D, Errett L, Mazer CD: Triple nutrient supplementation (TNS) improves survival, infarct size and cardiac function following myocardial infarction in rats. Nutr Metab Cardiovasc Dis, 2008;18(2):105-11.

Brooks D, Davis A, Naglie G: The feasibility of six-minute and two-minute walk tests in inpatient geriatric rehabilitation. Can J Aging, 2007;26:159-62.

Brooks D, Sottana R, Bell B, Hanna M, Laframboise L, Selvanayagarajah S, Goldstein R: Characterization of pulmonary rehabilitation programs in Canada in 2005. Can Respir J, 2007;14:87-92.

Bucci C, Mamdami, MM, Juurlink DN, Tu JV: Dihydropyridine calcium channel blockers and cardiovascular outcomes in elderly patients: a population-based study. Can J Cardiol, 2008;24:629-32.

Bunda S, Liu P, Wang Y, Liu K, Hinek A: Aldosterone induces elastin production in cardiac fibroblasts through activation of IGF-1 receptor in MR-independent manner. Am J Pathol, 2007:171:809-19.

Burra TA, Chen E, McIntyre RS, Grace SL, Blackmore ER, Stewart DE: Predictors of self-reported antidepressant adherence. Behav Med, 2007;32:127-34.

Butany J, Dixit V, Leong SW, Daniel LB, Mezody M, David TE: Inflammatory myofibroblastic tumor with valvular involvement: a case report and review of the literature. Cardiovasc Pathol, 2007;16(6):359-64.

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Butany JW, Gotlieb AI: Cardiovascular Neoplasms. IN: Seminars in Diagnostic Pathology. (ED: Santa Cruz, DJ). 2008;25.

Butany J, Leong SW, Cunningham KS, D’Cruz G, Carmichael K, Yau TM: A 10-year comparison of explanted Hancock-II and Carpentier-Edwards supraannular bioprostheses. Cardiovasc Pathol, 2007;16(1):4-13.

Butany J, Zhou T, Leong SW, Cunningham KS, Thangaroopan M, Jegatheeswaran A, Feindel C, David TE. Inflammation and infection in nine surgically explanted Medtronic Freestyle ® Stentless aortic valves. Cardiovasc Pathol, 2007;16(5):258-67.

Butcher JA, Simmons CA, Warnock J: Aortic valve mechanobiology. J Heart Valve Dis, 2008;17:62-73.

Butler MJ, Sefton MV: A poly(butyl methacrylate-co-methacrylic acid) tissue engineering scaffold with proangiogenic potential in vivo. J Biomed Mater Res, 2007;82A:265-73.

Cameron JI, Cheung AM, Streiner DL, Coyte PC, Singh MD, Stewart DE: Factor structure and reliability of the brain impairment behavior inventory. J Neurosci Nurs, 2008;40:40-7.

Carr SJ, Goldstein RS, Brooks, D: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in subjects completing pulmonary rehabilitation. Chest, 2007;132:127-34.

Chalmers J, Lin SY, Martino T, Arab S, Liu P, Husain M, Sole M, Belsham D: Diurnal profiling of neuroendocrine genes in murine heart, and shift in proopiomelanocortin gene expression with pressure-overload cardiac hypertrophy. J Mol Endocrinol, 2008 Jun 12. [Epub ahead of print]

Chan CT, Notarius CF, Merlocco A, Floras JS: Improvement in exercise duration and capacity after conversion to nocturnal home haemodialysis. Nephrol Dialysis Transplant, 2007;22:3285-91.

Chan K, Jensen N, O’Brien PJ: Structure-activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p-benzoquinone compounds. J Appl Toxicol, 2008;28(5):608-20.

Chan K, Jensen NS, Silbert PM, O’Brien PJ: Structure-activity relationships for halobenzene induced cytotoxicity in rat and human hepatocytes. Chem Biol Interact, 2007;165:165-74.

Cheung A, Lee Y, Kapral M, Scher J, Ho I, Lui-Yee D, Stewart DE: Barriers and motivations for women to participate in cardiovascular trails. J Obstet Gynecol Canada, 2008;30(4):332-7.

Chow CM, Chu JY, Tu JV, Moe GM: Lack of awareness of heart disease and stroke among Chinese Canadians: results of a pilot study of the Chinese Canadian Cardiovascular Health Project. Can J Cardiol, 2008;24:623-8.

Cimini M, Fazel S, Fujii H, Zhou S, Tang G, Weisel RD, Li R-K: The MRL mouse heart does not recover ventricular function after a myocardial infarction. Cardiovasc Pathol, 2008;17:32-9.

Cimini M, Fazel S, Zhuo S, Xaymardan M, Fujii H, Weisel RD, Li R-K: c-Kit dysfunction impairs myocardial healing after infarction. Circulation, 2007;116(Suppl II):77-82.

37

Collins MJ, Butany J, Borger MA, Strauss BA, David TE: Implications of a congenitally abnormal valve, a study of 1025 consecutively exised aortic valves. J Clin Pathol, 2008;61(4):530-6.

Collins MJ, Dev V, Strauss BH, Fedak PW, Butany J: Variation in the histopathological features of patients with ascending aortic aneurysms: a study of 111 surgically excised cases. J Clin Pathol, 2008;61(4):519-23.

Connelly PW, Maguire GF, Picardo CM, Teiber JF, Draganov D: Development of an immunoblot assay with infrared fluorescence to quantify paraoxonase 1 in serum and plasma. J Lipid Res, 2008;49:245-50.

Courtney BK, Munce NR, Anderson KJ, Thind AS,… Wright GA, Strauss BH: Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography's blind-spot. Eur Heart J, 2008;29(5):583-93.

Dajnowiec D, Langille BL: Arterial adaptations to chronic changes in hemodynamic function:  coupling vasomotor tone to structural remodeling. Clin Sci, 2007;113:15-23.

Dajnowiec D, Sabatini PJB, Zhang M, Langille BL: Force-induced polarized mitosis of endothelial and smooth muscle cells in arterial remodeling. Hypertension, 2007;50:255-60.

Davies RR, Russo MJ, Hong KN,… Mital S, Mosca RS, Chen JM: The use of mechanical circulatory support as a bridge to transplantation in pediatric patients: an analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg, 2008;135(2):421-7.

Davies RR, Russo MJ, Mital S, Martens TM, et al: Predicting survival among high-risk pediatric cardiac transplant recipients: an analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg, 2008;135(2):147-55.

Degousee N, Fazel S, Angoulvant D, Stefanski E, Pawelzik SW, Korotkova M, Arab S, Liu P, Lindsay TF, Zhuo S, Butany J, Li RK, et al: Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction. Circulation, 2008;117(13):1701-10. [Epub 2008 Mar 17]

Demers V, Melo M, Jackevicius C, Cox J,… Tu JV, Pilote L: Are Canadians equal when it comes to prescription drug cost-sharing policies? Can Med Assoc J, 2008;178:405-9.

Depeint F, Bruce WR, Lee O, Mehta R, O’Brien PJ: Micronutrients That Decrease Endogenous Toxins, A Strategy For Disease Prevention. IN: Micronutrients and Health Research. (EDS: Takumi Y, Columbus F), Nova Science Publishers, 2008;147-79.

Depeint F, Shangari N, Bruce WR, O’Brien PJ: Marginal thiamine deficiency increases oxidative stress biomarkers on the plasma and selective tisues in F344 rats. Nutr Res, 2007;27(11):698-704.

Detsky JS, Stainsby JA, Vijayaraghavan R, Graham JJ, Dick AJ, Wright GA: Inversion recovery-prepared SSFP for cardiac-phase-resolved delayed enhancement MRI. Magn Reson Med, 2007;58(2):365-72.

38

Diaz-Granados N, Stewart DE: Using a gender lens to monitor mental health. Int J Public Health, 2007;52:197-8.

Dill-Macky MJ, Wilson SR, Kachura J, Lindsay TF: Detecting endoleaks in aortic endofrafts using contrast-enhanced sonography. Am J Radiol, 2007;188(3):262-8.

Dixit V, Vaideeswar P, Butany J, David TE: The Ross procedure-valvular pathology of synchronous pulmonary autograft and homograft insufficiency. Hum Pathol, 2007. [Epub ahead of print]

Doenst T, Borger MA, Weisel RD, Yau TM, Maganti M, Rao V: Relation between aortic cross-clamp time and mortality – not as straightforward as expected. Eur J Cardiothorac Surg, 2008;33:660-5.

Dorian P, Pinter A, Mangat I, Korley V, Cvitkovic SS, Beatch GN: The effect of Vernakalant (RSD 1235), an investigational antiarrhythmic agent, on atrial electrophysiology in humans. J Cardiovasc Pharmacol, 2007;50(1):35-40.

Dos Santos CC, Okutani D, Hu B, Han B,… Slutsky AS, Zhang H, Liu M: Differential gene profiling in acute lung injury identifies injury-specific gene expression. Crit Care Med, 2008;36(3):855-65.

Enrica F, Dongge L, Jingyi P, Jaques B: Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat. Am J Respir Crit Care Med, 2007;176(10):1035-40.

Ezekowitz JA, Lee DS, Tu JV, Newman AM, McAlister FA: Comparison of one-year outcome (death and rehospitalization) in hospitalized heart failure patients with left ventricular ejection fraction >50% versus those with ejection fraction <50%. Am J Cardiol, 2008;102:79-83.

Fayet C, Bendeck M, Gotlieb AI: Cardiac valve interstitial cells secrete fibronectin and form fibrillar adhesions in response to injury. Cardiovasc Pathol, 2007;16:203-11.

Fazel SS, Chen L, Angoulvant D, Li S-H, Weisel RD, Keating A, Li R-K: Activation of c-kit is necessary for mobilization of reparative bone marrow progenitor cells in response to cardiac injury. FASEB J, 2008;22:930-40.

Ferguson N, Slutsky AS: Last word on Point:Counterpoint: high-frequency ventilation is/is not the optimal physiological approach to ventilate ARDS patients. J Applied Physiol, 2008;104(4):1240.

Fergusson DA, Hébert PC, Mazer CD, Fremes S,… Wells G, Clinch J, Pretorius R for the BART Investigators: A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med, 2008;358(22):2319-31.

Fernandez-Duque D, Black SE: Selective attention in early dementia of Alzheimer type. Brain Cogn, 2008;66(3):221-31.

Floras JS, Bradley TD: Treating obstructive sleep apnea: is there more to the story than 2 millimeters of mercury? Hypertension, 2007;50:289-91.

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Floras JS: Ambulatory blood pressure: facilitating individualized assessment of cardiovascular risk. J Hypertens, 2007;25:1565-8.

Fujiwara E, Schwartz ML, Gao F, Black SE, Levine B: Ventral frontal cortex functions and quantified MRI in traumatic brain injury. Neuropsychologia, 2008;46(2):461-74.

Fullerton A, Macdonald M, Brown A, Ho P-L,… Brooks D: Survey of fitness facilities for stroke survivors in the greater Toronto area. Appl Nutr, Physiol Metabolism, 2008;133:1-7.

Gage WH, Zabjek KF, Sibley KM, Tang A, Brooks D, McIlroy WE: Ambulatory monitoring of activity levels of individuals in the sub-acute stage following stroke. J Neuroeng Rehabil, 2007;4:41.

Gagnon AJ, Dougherty G, Platt RW, Wahoush O,… Stewart DE: Refugee and refugee-claimant women and infants post-birth: migration histories as a predictor of Canadian health system response to needs. Can J Public Health, 2007;98:287-91.

Gajic-Veljanoski O, Stewart DE: Women trafficked into prostitution: determinants, human rights and health needs. Transcult Psychiatry, 2007;44:338-58.

Gershon AS, Tu JV: The effect of privacy legislation on observational research. A commentary. Can Med Assoc J, 2008;178:871-3.

Gershon AS, Wobeser W, Tu JV: Delayed tuberculosis treatment in urban and suburban Ontario. Can Respir J, 2008;244-8.

Ghosh N, Nesbitt G, Rocca A, Butany J, Provost Y, Ross H: An unappetizing dog bone: cardiac sarcoidosis presenting with heart block and unusual left ventricular bulding. Eur Heart J, 2008;29(11):1358. [Epub 2007 Dec 7]

Gilman MP, Floras JS, Usui K, Kaneko Y, Leung RST, Bradley TD: Continuous positive airway pressure increases heart rate variability in heart failure patients with obstructive sleep apnoea. Clin Sci, 2008;114:243-9.

Gilmore ED, Hudson C, Nrusimhadevara RK, Ridout R, et al: Retinal arteriolar diameter, blood velocity and blood flow response to a combined isocapnic hyperoxia and glucose provocation in early and sight-threatening diabetic retinopathy. Invest Ophthalmol Vis Sci, 2008;49:699-705.

Gladstone DJ, Blakely J, Dorian P, Spring M, Fang J, Silver FL, Kapral MK, for the EMBRACE Pilot Study Group: Detecting paroxysmal atrial fibrillation after ischemic stroke and transient attack: if you don’t look, you won’t find. Stroke, 2008;39(5):e78-9.

Gonzalez AMD, Osorio JC, Manlhiot C, Gruber G, Homma S, Mital S: Hypertrophy signaling during peripartum cardiac remodeling. Am J Physiol Heart Circ Physiol, 2007;293(5):H3008-13.

Gotlieb AI: Cardiac Fibroma. IN: Seminars Diagnostic Pathol, 2008;25:17-9.

Gotlieb AI: The Road to Becoming a Biomedical Physician-Scientist in Pathology and Laboratory Medicine. Intersociety Council for Pathology Information, Inc. Bethesda, MD, p1-18, 2007.

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Grace SL, Barry-Bianchi S, Stewart DE, Rukholm E, Nolan RP: Physical activity behavior, motivational readiness and self-efficacy among Ontarians with cardiovascular disease and diabetes. J Behav Med, 2007;30:21-9.

Grace SL, Gravely-Witte S, Brual J, Suskin N, Alter DA, Higginson L, Stewart DE: Contribution of patient and physician factors to cardiac rehabilitation referral: a prospective multi-level study. Nature Clin Prac: Cardiovasc Med, 2008 June 10. (Published online)

Grace SL, Grewal K, Arthur HM, Abramson BL, Stewart DE: A prospective, controlled multi-site study of psychosocial and behavioral change following women’s cardiac rehabilitation participation. J Women’s Health, 2008;17(2):241-8.

Grace SL, Leung YW, Stewart DE: A prospective examination of antidepressant use and its correlates in patients with acute coronary syndrome. Psychosomatics, 2008;49:199-207.

Grace SL, Scholey P, Suskin N, Arthur H, Brooks D, Jaglal S, Abramson BL, Stewart DE: A prospective comparison of cardiac rehabilitation enrolment following automatic versus usual referral. J Rehabil Med, 2007;39(3):239-45.

Gramolini AO, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson NJ,… Backx PH, Liu PP, MacLennan DH, Emili A: Comparative proteomic profiling of a phospholamban mutant mouse model of heart failure reveals progressive intracellular stress responses associated with dilated cardiomyopathy. Mol Cell Proteomics, 2008;7:519-33.

Gramolini AO, Pederman S, Kislinger T: Mass-spectrometry based proteomics: a useful tool for biomarker discover. Clin Pharmacol Therapeutics, 2008;83:758-60.

Grasselli G, Gattinoni L, Kavanagh B, Latini R,… Slutsky A, Tognoni G: Feasibility, limits and problems of clinical studies in Intensive Care Unit. Minerva Anestesiol, 2007;73(11):595-601.

Gravely-Witte S, Stewart DE, Higginson L, Suskin N, Alter DA, Grace SL: Cardiologists’ charting varied by risk factor, and was often discordant with patient report. J Clin Epidemiol, 2008, April 12. (Published online)

Gruh I, Wunderlich S, Winkler M, Schwanke K,… Li R-K, Haverich A, Martin U: Human CMV immediate-early enhancer: a useful tool to enhance cell-type-specific expression from lentiviral vectors. J Gene Med, 2007;10(1):21-32.

Gucciardi E, Cameron JI, Liao CD, Palmer A, Stewart DE: Program design features that can improve participation in health education interventions. BMC Med Res Methodol, 2007;7:47.

Gucciardi E, DeMelo M, Offenheim A, Grace SL, Stewart DE: Patient factors associated with attrition from a self-management education. J Clin Practice, 2007;13:913-19.

Gucciardi E, DeMelo M, Offenheim A, Stewart DE: Factors contributing to attrition behavior in diabetes self-management programs: A mixed method approach. BMC Health Services Res, 2008;8(1):33.

Gucciardi E, Wang SC, Badiani T, Stewart DE: Beyond adolescence exploring Canadian women and men’s perception of overweight. Womens Health Issues, 2007;17:374-82.

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Gucciardi E, Wang SC, DeMelo M, Amaral L, Stewart DE: Characteristics of men and women with diabetes: observations during patients' initial visit to a diabetes education centre. Can Fam Physician, 2008;54(2):219-27.

Gui T, Reheman A, Funkhouser WK, Bellinger DA,… Ni H: In vivo response to vascular injury in the absence of factor IX: examination in factor IX knockout mice. Thromb Res, 2007;121(2):225-34.

Gupta N, Ang LC, Girard E, Yücel YH: Retinal tau pathology in human glaucomas. Can J Ophthalmol, 2008;43:53-60.

Gupta N, Yücel YH: What changes can we expect in the brain of glaucoma patients? Survey of Ophthalmol, 2008;52(Suppl 2):S122-6.

Guru V, Tu JV, Etchells E, Anderson GM, Naylor CD, Novick RJ, Feindel CM,… Fremes SE: Relationship between preventability of death after CABG surgery and all cause risk-adjusted mortality rates. Circulation, 2008;117:2969-76.

Haitsma JJ, Schultz MJ, Slutsky AS: Cytokine Release. IN: Mechanical Ventilation - Clinical Applications and Pathophysiology, (EDS: Papadakos, PJ, Lachmann B), Saunders Elsevier, Philadelphia, 2007:216-224.

Haitsma JJ, Slutsky AS: Ventilator-Induced Lung Injury. IN: Mechanical Ventilation - Clinical Applications and Pathophysiology (EDS: Papadakos PJ, Lachmann B), Saunders Elsevier, Philadelphia, 2007:42-50.

Haitsma JJ, Slutsky AS: Ventilator-Induced Lung Injury. IN: Mechanical Ventilation - Clincial Applications and Pathophysiology (EDS: Papadakos PJ, Lachmann B), Saunders Elsevier, Philadelphia, 2007:615-23.

Hales R, Gabbard G, Phillips K, Oldham J, Stewart DE: Practical strategies for becoming a successful medical book author. Acad Psychiatry, 2008;32(3):183-7.

Handa S, Sadi MA, Cybulsky MI, Stewart DJ, Husain M: Region-specific patterns of vascular remodeling occur early in atherosclerosis and without loss of smooth muscle cell markers Atherosclerosis, 2007;196(2):617-23.

Herrmann N, Rothenburg LS, Black SE, Ryan M, Liu BA, Busto UE, Lancôt KL: Methylphenidate for the treatment of apathy in Alzheimer’s Disease: prediction of response using dextroamphetamine challenge. J Clin Psychopharmacol, 2008;28(3):296-301.

Hicks L, Laupacis A, Slutsky AS: A primer on data safety monitoring boards: mission, methods, and controversies. Intensive Care Med, 2007;33(10):1815-8.

Hill CH, Ashwell CM, Nolin SI, Keely F, Billingham K, Hinek A, Starcher B: Dietary iron deficiency compromises normal development of elastic fibers in the aorta and lungs of chicks. J Nutrition, 2007;137:1895-1900.

Hill K, Goldstein R, Gartner E, Brooks D: Satisfaction with rollators among individuals with chronic obstructive pulmonary disease. Arch Phys Med Rehabil, 2008;89(6).

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Hsiung G-YR, Alipour S, Jacova C, Grand J, Gauthier S, Black SE, et al: Transitions from cognitively impaired not demented to Alzheimer’s Disease: an analysis of changes in functional abilities in a dementia clinic cohort. Dement Geriatr Cogn Disord, 2008;25(6):483-90.

Huang Y, Wright GA: Time-resolved MR angiography with limited projections. Magn Reson Med, 2007;58(2):316-25.

Hudson C: A review of diabetic retinopathy. Geriatrics and Aging, 2008;11:333-41. (Invited Review) (For CE web version see http://www.geriatricsandaging.com/).

Hudson LD, Slutsky AS: Acute Respiratory Failure. IN: Cecil Medicine, 23rd Edition (EDS: Goldman L, Ausiello D), Saunders Elsevier, Philadelphia, 2007:723-34.

Humphries KH, Lee M, Sheldon R, Ramanathan K, Dorian P, Green M, Kerr CR, for the CARAF Investigators: Statin use and recurrence of atrial fibrillation after successful cardioversion. Am Heart J, 2007;154(5):908-13.

Husain M: Introductory Essay: Diagnosis and Treatment. IN: The Endothelium: A Comprehensive Reference. (ED Aird W). Cambridge University Press. 2007, Chapter 172 p1599-1601.

Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R,… Slutsky AS, Akira S, et al: Identification of oxidative stress and toll-like receptor 4 signalling as a key pathway of acute lung injury. Cell, 2008;133(2):235-49.

Ishida S, Takeuchi A, Azami T, Sobue K, Sasano H, Katsuya H, Fisher JA: Cardiac output increases the rate of CO elimination in hyperpneic but not normally ventilated dogs. J Anesth, 2007;21(2):181-6.

Ito S, Mardimae A, Han J, Duffin J,… Kessler C, Fisher JA: Non-invasive prospective targeting of artieral PCO2 in subjects at rest. J Physiol (Lond), 2008. [Epub July]

Ivanov J, Borger MA, Tu JV, Rao V, David TE: Mid-term outcomes of off-pump versus on-pump coronary artery bypass graft surgery. Can J Cardiol, 2008;24:279-84.

Jackevicius CA, Li P, Tu JV: Prevalence, predictors and outcomes of primary nonadherence post-acute myocardial infarction. Circulation, 2008;117:1028-36.

Jackevicius CA, Tu JV, Ross JS, Ko DT, Krumholz HM: Use of Ezetimibe in the United States and Canada. N Engl J Med, 2008;358:1819-28.

Jankov RP, Kantores C, Pan J, Belik J: Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats. Am J Physiol Lung Cell Mol Physiol, 2008;294:L233-4.

Jaques B, Nadine H, Jingyi P, Soenke B: Soluble guanylate cyclase-dependent relaxation is reduced in the adult rat bronchial smooth muscle. Am.J.Physiol Lung Cell Mol.Physiol, 2007;292(3):L699-703.

Jenkins DJA, Josse AR, Beyene J, Dorian P, et al: Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis. CMAJ, 2008;178(2):157-64.

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Jenkins DJ, Kendall CW, Nguyen TH, Marchie A,…Connelly PW, Singer W: Effect of plant sterols in combination with other cholesterol-lowering foods. Metabolism, 2008;57:130-9.

Kalliomäki T, McCallum GP, Lunt SJ, Wells PG, Hill RP: Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model. BMC Cancer, 2008;8:151-64.

Kan CD, Li S-H, Weisel RD, Zhang S, Li R-K: Recipient age determines the cardiac functional improvement achieved by skeletal myoblast transplantation. J Am Coll Cardiol, 2007;50:1086-92.

Karkouti K, Beattie WS, Yau TM, Arellano R,… Mazer D, Muirhead B, et al: A comprehensive Canadian review of the off-label use of recombinant activated Factor VII in cardiac surgery. Circulation, 2008;118(4):331-8.

Karkouti K, Wijeysundera DN, Beattie WS,… Mazer D, Rubens FD, Sawchuk C, Yau TM for the Reducing Bleeding in Cardiac Surgery (RBC) Research Group: Variability and predictability of large-volume red blood cell transfusion in cardiac surgery: a multicenter study. Transfusion, 2007;47(11):2081-8.

Karkouti K, Wijeysundera DN, Yau TM, McCluskey SA, Van Rensburg A, Beattie WS: The influence of baseline hemoglobin concentration on tolerance of anemia in cardiac surgery. Transfusion, 2008;48:666-72.

Katznelson R, Minkovich L, Friedman Z, Fedorko L, Beattie S, Fisher JA: Accelerated recovery from sevoflurane anesthesia with isocapnic hyperpnoea. Anesth Analg, 2008;106(2):486-91.

Kaufman BD, Auerbach S, Reddy S, Manlhiot C,…Mital S: RAAS gene polymorphisms influence progression of pediatric hypertrophic cardiomyopathy. Hum Genet, 2007;122(5):515-23.

Kavanagh T, Watt-Watson J, Stevens B: A critical examination of the factors enabling the successful implementation of evidence-based acute pain practices into pediatric nursing. Children’s Health Care, 2007.

Kavanagh T, Watt-Watson J: Pediatric pain education: a call for innovation and change. Paediatrics and Child Health, 2007;12(2):97-9.

Khan NA, Butany J, Zhou T, Ross HJ, Rao V: Pathological findings in explanted prosthetic heart valves tram ventricular assist devices. Pathology, 2008;40(4):377-84.

Khan NA, Hemmeigam B, Padwal R, et al, Ogilvie RI: The 2007 Canadian Hypertension Education Program Recommendations for the management of hypertension. Part 2 Therapy. Can J Cardiol, 2007;23:539-50.

Khan NA, Hemmeigam B, Padwal R, et al, Ogilvie RI: The 2008 Canadian Hypertension Education Program Recommendations for the management of hypertension. Part 2 Therapy. Can J Cardiol, 2007;24:465-75.

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Kim BO, Verma S, Weisel RD, Fazel S, Jia Z-Q, Mizuno T, Li R-K: Preservation of heart function in diabetic rats by the combined effects of muscle cell implantation and insulin therapy. Eur J Heart Fail, 2008;10:14-21.

Kirton A, Tan M, Mikulis D, Fisher JA, Han J, deVeber G, Rubin B: Recurrent reversible coma in an adolescent. Lancet Neurol, 2008;7(1):110-2.

Kisilevsky M, Hudson C, Wong T, Mardimae A, Fisher JA: Concentration dependent vasoconstrictive effect of hyperoxia on hypercarbia-dilated retinal arterioles. Microvasc Res, 2008;75(2):263-8. [Epub 2007 Aug 28]

Ko DT, Alter DA, Austin PC, You JJ, Lee DS, Qiu F, Stukel TA, Tu JV: Life expectancy after an index hospitalization for patients with heart failure: a population-based study. Am Heart J, 2008;155:324-31.

Ko DT, Chiu M, Austin PC, Bowen J, Cohen EA, Tu JV: Safety and effectiveness of drug-eluting stents among diabetic patients: a propensity analysis. Am Heart J, 2008;156:125-34.

Ko SC, Zhang H, Haitsma JJ, Cheng KC, Li CF, Slutsky AS: Effects of PEEP levels following repeated recruitment maneuvers on ventilator-induced lung injury. Acta Anaesthesiol Scand, 2008;52:514-21.

Kolodziejska KM, Noyan AH, Nagy A, Bacon A,… Husain M: c-Myb-dependent smooth muscle cell differentiation. Circ Res, 2008;102(5):554-61. [Epub 2008 Jan 10]

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Kontos PC, Miller K-L, Brooks D, Jassal SV, et al: Factors influencing exercise participation by older adults requiring chronic hemodialysis: a qualitative study. Int Urol Nephrol, 2007;39:303-11.

Laczko R, Szauter KM, Jansen MK, Hollosi P,… Hinek A, Csiszar K: Active lysyl oxidase (LOX) correlates with focal adhesion kinase (FAK)/paxillin activation and migration in invasive astrocytes. Neuropathol Appl Neurobiol, 2007;33(6):631-43.

Lakkireddy D, Wallick D, Verma A, Ryschon K,… Butany J, Martin D, Tchou PJ: Cardiac effects of electrical stun guns: Does position of barbs contact make a different? Pacing Clin Electrophysiol, 2008;31(4):398-408.

Lanctôt KL, Herrmann N, Ganjavi H, Black SE, et al: Serotonin-1A receptors in frontotemporal dementia compared with controls. Psychiatry Res Neuroimaging, 2007;156(3):247-50.

Lanctôt KL, Hussey DF, herrmann N, Rusjan PM, Black SE, et al: A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer Disease. Am J Geriatr Psychiatry, 2007;15(1):888-98.

Laurent G, Moe G, Hu X, Holub B, Leong-Poi H, Trogadis J, Connelly K, Courtman D, Strauss BH, Dorian P: Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing model. Cardiovasc Res, 2008;77(1):89-97.

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Laurent G, Moe GW, Hu X, Leong-Poi H,… Courtman DW, Strauss B, Dorian P: Experimental studies of atrial fibrillation: comparison of two pacing models. Am J Physiol Heart Circ Physiol, 2008;294(3):H1206-15.

Laurent G, Moe GW, Hu X, So PP, Ramadeen A, Leong-Poi H,… Courtman D, Strauss BH, Dorian P: Simultaneous right atrioventricular pacing: a novel model to study atrial remodeling and fibrillation in the setting of heart failure. J Card Fail, 2008;14(3):254-62.

Lee DS, Tu JV, Austin PC, Dorian P, Yee R, Chong A, Alter DA, Laupacis A: Effect of cardiac and non-cardiac conditions on survival after defibrillator implantation. J Am Coll Cardiol, 2007;49:2408-15.

Lee DS, Tu JV, Juurlink DN: Do Ontario patients with heart failure have equal access to life-saving technology? Healthc Q, 2008;11:20-1.

Lelièvre E, Hinek A, Lupu F, Buquet C, Soncin F, Mattot V: VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases. EMBO, J, 2008;27(12):1658-70.

Leung BM, Sefton MV: A modular tissue engineering construct containing smooth muscle cells and endothelial cells. Ann Biomed Eng, 2007;35:2039-49.

Leung Y, Grace SL, Arthur H, Stewart DE: The prevalence and correlates of mind-body therapy practices in patients with acute coronary syndrome. J Comp Therap Med, 2007.

Leung YW, Ceccato N, Stewart DE, Grace SL: A prospective examination of patterns and correlates of exercise maintenance in coronary artery disease patients. J Behav Med, 2007;30:411-21.

Levine B, Kovacevic N, Nica EI, Cheung G, Gao F, Schwartz ML, Black SE: The Toronto traumatic brain injury study I: injury severity and quantified MRI. Neurology, 2008;70:771-8.

Levy-Cooperman N, Burhan AM, Rafi-Tari S, Kusano M, Ramirez J, Caldwell C, Black SE: Frontal lobe hypoperfusion and depressive symptoms in Alzheimer’s Disease. J Psychiatry Neurosci, 2008;33(3):218-26.

Levy-Cooperman N, Lobaugh NJ, Caldwell C, Gao F, Black SE: Subcortical hyperintensities in Alzheimer’s Disease: no clear relationship with executive function and frontal perfusion on SPECT. Dement Geriatr Cogn Disord, 2007;24(5):380-8.

Levy-Cooperman N, Ramirez J, Lobaugh NJ, Black SE: Misclassified tissues volumes in Alzheimer’s Disease patients with white matter hyperintensities: importance of lesion segmentation procedures for volumetric analysis. Stroke, 2008;39(4):1134-41.

Ley SH, Harris SB, Connelly PW, Mamakeesick M, Gittelsohn J, et al: Adipokines and incident Type 2 diabetes in an aboriginal Canadian population: The Sandy Lake Health and Diabetes Project. Diab Care, 2008;31:1410-16.

Leytin V, Allen DJ, Mutlu A, Mykhaylov S, Lyubimov E, Freedman J: Platelet activation and apoptosis are different phenomena: evidence from the sequential dynamics and the magnitude

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Li W, Ma N, Ong LL, Kaminski A,… Li R-K, Steinhoff G: Enhanced thoracic gene delivery by magnetic nanobead-mediated vector. J Gene Med, 2008;10(8):897-909.

Li W, Ma N, Ong L-L, Nesselmann C,… Li R-K, Steinhoff G: Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells, 2007;25(8):2118-27.

Li W, Young EWK, Seo M, Nie Z, Garstecki P, Simmons CA, Kumacheva E: Simultaneous microfluidic generation of droplets with different dimensions. Soft Matter, 2008;4-258-62.

Li Y, Wong HL, Shuhendler A, Rauth AM, Wu XY: Molecular interactions, internal structure and drug release kinetics of rationally developed polymer-lipid hybrid nanoparticles (PLN). J Control Release, 2008;128:60-70.

Litvinovich E, O’Brien PJ: Modulation of Gamma-Hydroxybutyrate Induced Sleep Using Hepatic AKR7A5 and AKR1A4 Inhibitors. IN: Enzymology and Molecular Biology of Carbonyl Metabolism. (EDS: Weiner H, Plapp B, Lindahl R, Maser E). Purdue University Press, West Lafayette, Indiana, 2007;13:389-93.

Liu AC, Gotlieb AI: Characterization of cell motility in single heart valve interstitial cells in-vitro. Histol Histopathol, 2007;22:873-82.

Liu AC, Joag VR, Gotlieb, AI: The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. Am J Pathol, 2007;171:1407-18.

Liu J, Meisner D, Kwong E, Wu XY, Johnston MR: A novel trans-lymphatic drug delivery system: implantable gelatin sponge impregnated with PLGA-paclitaxel microspheres. Biomaterials, 2007;28(21):3236-44.

Liu Q, Rauth AM, Wu XY: Immobilization and bioactivity of glucose oxidase in hydrogel microspheres by an emulsification-internal gelation-adsorption-polyeletrolyte coating method. Int J Pharm, 2007;339:148-56.

Luk A, Ahn E, Vaideeswar P, Butany J: Pericardiac tumors. Semin Diagn Pathol, 2008;25(1):47-53.

Luk A, Butany J, Erlich SA, Henry J, David TE: Long-term morphological changes in a cryopreserved pulmonary valve homograft. Can J Cardiol, 2007;23(10):817-9.

Madore AM, Houde L, Vezina H, Vohl MC, Perusse L, Mior N, Connelly PW, Laberge C, Gaudet D, Laprise C: Contribution of hierarchical clustering techniques to the modeling of the geographic distribution of genetic polymorphisms associated with chronic inflammatory diseases in the Quebec population. Community Genet, 2007;10:218-26.

Mandell DM, Han J, Poublanc J, Crawley AP, Stainsby JA, Kassner A, Fisher JA, Mikulis DJ: Selective reduction of blood flow to white matter during hypercapnia corresponds with leukoaraiosis. Stroke, 2008;39(7):1993-8.

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Mandell DM, Han JS, Poublanc J, Crawley AP, Stainsby JA, Fisher JA, Mikulis DJ: Mapping cerebrovascular reactivity using BOLD MRI in patients with artieral steno-occlusive disease: comparison with arterial spin labeling MRI. Stroke, 2008;39(7):2021-8.

Masellis M, Black SE: Assessing patients complaining of memory impairment. Geriatr Aging, 2008;11(3):168-78.

Mazer CD, Leong-Poi H, Mahoney J, Latter D, Strauss B, Teitel J: Vascular injury and thrombotic potential: a note of caution about recombinant factor VIIa. Simin Cardiothorac Vasc Anesth, 2007;11(4):261-4.

Mazer CD for the BART Investigators: Safety and efficacy of antifibrinolytic therapy: recent controversies and the BART trial. Heart Surg Forum, 2007;5(2):10-2.

McCrindle BW, Williams RV, Mital S, Clark BJ, Russell JL, Klein G, Eisenmann JC: Physical activity levels in children and adolescents are reduced after the Fontan procedure, independent of exercise capacity and are associated with lower perceived general health. Arch Dis Child, 2007;92:509-14.

McGillion M, Andréll P, Watt-Watson J, Arthur H: Self-management training in refractory angina. Br Med J, 2008;336:338-9.

McGillion M, Watt-Watson J, LeFort S, Stevens B: Impact of psychoeducation on the meaning of cardiac pain for people with chronic stable angina. Can J Nurs Res, 2007;39:48-65.

McGuigan AP, Sefton MV: Design and fabrication of sub-mm sized modules containing encapsulated cells for modular tissue engineering. Tissue Eng, 2007;13(5):1069-78.

McGuigan AP, Sefton MV: Design criteria for a modular tissue-engineered construct. Tissue Eng, 2007;13(5):1079-89.

McGuigan AP, Sefton MV: Modular tissue engineering: fabrication of a gelatin-based construct. Tissue Eng Reg Med, 2007;1:136-45.

McGuigan AP, Sefton MV: The influence of biomaterials on endothelial cell thrombogenicity. Biomaterials, 2007;28:2547-71.

McGuigan AP, Sefton MV: The thrombogenicity of human umbilical vein endothelial cell seeded collagen modules. Biomaterials, 2008;29:2453-63.

Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Lung Open Ventilation Study Investigators, et al, (Mazer CD, site investigator): Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA, 2008;299(6):637-45.

Mentzer RM, Bartels C, Bolli R, Boyce S, et al, Weisel RD (EXPEDITION Study Investigators): Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. Ann Thorac Surg, 2008;85:1261-70.

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Merrilees MJ, Ching PST, Beaumont B, Hinek A, Wight TN, Black PN: Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonay disease. J Respir Res, 2008;9:41.

Mehta R, Lee O, Chan K, Tafazoli S, O’Brien PJ: Drug Associated Mitochondrial Toxicity. IN: Drug Induced Mitochondrial Dysfunction. (EDS: Dykens J, Will Y) Wiley Co, 2008.

Mehta R, O’Brien PJ: Preventing cell death induced by carbonyl stress, oxidative stress or mitochondrial toxins with vitamin B and anti AGE agents. Mol Nutr Food Res, 2007;52:379-85.

Mehta R, O’Brien PJ: Therapeutic Intracellular Targets for Preventing Carbonyl Cell Death with B Vitamins or Drugs. IN: Enzymology and Molecular Biology of Carbonyl Metabolism. (EDS: Weiner H, Plapp B, Lindahl R, Maser E), Purdue University Press, West Lafayette, Indiana. 2007;13:113-20.

Mital S: Value of surveillance biopsy in pediatric heart transplantation. Pediatr Transplant, 2007;11:233-5. (Editorial)

Mital S: Ventricular fibrillation and use of automated external defibrillators on children: policy statement. Committee on Pediatric Emergency Medicine and Section on Cardiology and Cardiac Surgery. Pediatrics, 2007;120:1159-61.

Mitchell GF, Conlin PR, Dunlap ME, Arnold JM, Ogilvie RI, Neutel J, Izzo JL, Pfeffer MA: Aortic diameter, wall stiffness, and wave reflection in systolic hypertension. Hypertension, 2008;51:105-11.

Moerer O, Beck J, Brander L, Costa R, Quintel M, Slutsky AS, Brunet F, Sinderby C: Subject-ventilator synchrony during neural versus pneumatically triggered non-invasive helmet ventilation. Intensive Care Med, 2008. [Epub ahead of print]

Moltzan CJ, Anderson DA, Callum J, Fremes S, Hume H, Mazer CD, Poon MC, et al: The evidence for the use of recombinant factor VIIa in massive bleeding: development of a transfusion policy framework. Transfus Med, 2008;18:112-20.

Morrison LJ, Long J, Vermeulen M, Schwartz B,… Dorian P: A randomized controlled feasibility trial comparing safety and effectiveness of prehospital pacing versus conventional treatment: ‘PrePACE’. Resuscitation, 2008;76(3):341-9

Moselhy J, Sarkar S, Chia M, Mocanu J, Taulier N, Liu FF, Wu XY: Evaluation of NIPAM/DMAEM polymers in non-viral and adenoviral vectors for gene delivery to nasopharyngeal carcinoma. Int J Nanomedicine, 2007;2(3):1-18.

Motamed-Khorasani A, Jurisica I, Letarte M, et al: Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression. Oncogene, 2007;26:198-214.

Mu J, Qu D, Bartczak A, Phillips MJ,…Grant DR, Backx PH, Levy GA, Adamson SL: Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice. Physiol Genomics, 2007;31(1):53-62.

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Munce N, Mariampillai A, Standish B, Pop M,… Wright G, Vitkin A, Yang V: Electrostatic forward-viewing scanning probe for Doppler optical coherence tomography using a dissipative polymer catheter. Optics Letters, 2008;33(7):657-9.

Munce SE, Stansfeld SA, Blackmore ER, Stewart DE: The role of depression and chronic pain conditions in absenteeism: Results from a national epidemiologic survey. J Occup Environ Med, 2007;49:1206-11.

Munce SE, Stewart DE: Gender differences in depression and chronic pain conditions in a national epidemiologic survey. Psychosomatics, 2007;45:394-9.

Murphy DB, Fox AJ, Lee DH, Sahlas DJ, Back SE, et al: White matter thresholds for the ischemic penumbra and infarct core in acute stroke patients: a CT perfusion study. Radiology, 2008;247(3):818-25.

Mutlu A, Allen DJ, Freedman J, Leytin V: The level of matrix metalloproteinase-2 in donor plasma strongly correlates with posttransfusion recovery of stored platelet concentrates. Vox Sang, 2008;94:143-. (doi:10/1111/j.1423-0410.2007.01001. x).

Nanthakumar K, Jalife J, Masse S, Downar E, Pop M, Asta J, Ross H, Rao V,… Wright G, Dhopeshwarkar R: Optical mapping of langendorff perfused human hearts: establishing a model for the study of ventricular fibrillation in humans. Am J Physiol Heart Circ Physiol, 2007;293:H875-80.

Nanthakumar K, Masse S, Umapathy K, Dorian P, Sevaptsidis E, Waxman M: Cardiac stimulation with high voltage discharge from stun guns. CMAJ, 2008;178(11):1451-7.

Nassar B, Nanji A, Ransom T, Rockwood K, Kirkland S, MacPherson K, Connelly P, et al: The role of the fractalkine receptor CX3CR1 polymorphisms V249I and T280M as risk factors for early-onset coronary artery disease in patients without classic risk factors. Scand J Clin Lab Invest, 2008;68:186-91.

Newcomb AE, Pelenghi S, Karshi J, Butany J, David TE: Cardiac papillary muscle hemangioma. J Thorac Cardiovasc Surg, 2007;134(5):1345-6.

Noninvasive ultrasonic measurement of regional and local pulse-wave velocity in mice. Ultrasound Med Biol, 2007;33(9):1368-75.

Nonoyama ML Brooks D, Lacasse Y, Guyatt GH, Goldstein RS: Oxygen therapy during exercise training in chronic obstructive pulmonary disease. Art. No.: CD005372. DOI: 10.1002/14651858.CD005372.pub2

Nonoyama ML, Brooks D, Guyatt GH, Goldstein RS: Effect of oxygen on health quality of life in COPD patients with transient exertional hypoxemia. Am J Respir Crit Care Med, 2007;176:343-9.

Notarius CF, Spaak J, Morris BL, Floras JS: Comparison of muscle sympathetic activity in ischemic and non-ischemic heart failure. J Card Fail, 2007;13:470-5.

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