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Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

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Page 1: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt/β-catenin pathway

Seminar Spring 2011

Maneeshi Prasad21st Jan 2011

Man

Page 2: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt pathway

• Ligands

• Receptors

• Intracellular components

• Transcription factors

• Interactome

Page 3: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt

• “Wnt” is a combination of Wg (wingless) gene in Drosophila and Int gene in MMTV, two homologous genes

• Wnt are secreted proteins

• 19 Wnt genes in humans and mice

Page 4: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt Receptors

• Receptor tyrosine kinase

• Derailed/RYK

• ROR

• Frizzled-transmembrane receptor

• LRP (lipoprotein-receptor related protein)

• Single-pass Tm proteins

• Cytoplasmic tail phosphorylated by GSK3 and CK1γ

http://www.stanford.edu/group/nusselab/cgi-bin/wnt/main#Diagrams

Page 5: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt Pathway

Page 6: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt signaling

Page 7: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Interactions: Intracellular Components

Page 8: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Intracellular Components

Page 9: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Canonical/Non-canonical Wnt pathway

Page 10: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt Pathway Interactome

Page 11: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt pathway interactions

Page 12: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Role of Wnt signaling

Page 13: Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Role of Wnt signaling

• Development

• Neural development: CNS

• Neural crest

• Limb

• Tumor formation

• Cellular growth and proliferation