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KUMAR ORGANIC PRODUCTS LIMITED

Ingredients for us

BIO/003/2012-13Dr. Lakshmi Sridhar

18th Sep 2012

SODIUM HYALURONATE (KOPURON)

Pharma grade


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Sodium hyaluronate


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• INCI name: Sodium hyaluronate

• CAS No. 9057-32-7

• Product name: Poly-(sodium--D-glucuronate-[1-3}- N-acetyl-D-glucosamine-[1-4]

• Other names: Hyaluronic acid, Hyaluron, Hyaluronan

• EINECS/ELNICS: 232-678-0

Sodium Hyaluronate - Structure


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Sodium hyaluronate – (sodium salt of hyaluronic acid) is a linear chain muco-polysaccharide composed of disaccharide units formed from D-glucuronic acid & N- acetylglucosamine held together by -1,3-linkages

Sodium Hyaluronate


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• Polymer produced by the growth of the bacterium Streptococcus equi zooepidemicus; produced by bacterial fermentation; not of animal origin

• Non GMO; free of contaminants such as glycosaminoglycans & animal proteins

• Highly solubility; insoluble in water immiscible solvents

• Highly pure product; excellent transparency & stability

• Moisture retention; free radical scavenging, cell proliferation

Process Flow Diagram


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Sodium hyaluronate & the eye


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• Hyaluronic acid – significant constituent of human skin, connective tissue, vitreous humor of the eye, lubricant in joints,


• Hyaluronic acid is present in a high concentration inside the eyeball.

•Vitreous humor inside the eye is almost completely made up of hyaluronic acid

•The hyaluronic acid has gel like properties which give shock absorbing effect •Transports nutrients into the eye


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Other ophthalmic applications of Sodium hyaluronate

• Opthalmic drops – for post eye surgery care

• Contact lens solutions

• Artificial tears


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Sodium hyaluronate


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• With age, the hyaluronic acid in our joints decreases; leads to loss of cushioning & joint pains & aches. • Injections with Hyaluronic acid & cross linked hyaluronic acid gel give the joint lubrication & cushioning for load bearing


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•Intra–articular injections to alleviate joint pains in senior citizens, sports persons, patients recovering from fractures of bones

Sodium hyaluronate

Sodium hyaluronate


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• Tissue engineering & scaffolds & dermal fillers for cosmetic surgery

• Pharma grade hyaluronic acid is cross linked to form a gel

• Cross linked hyaluronic acid gels are more stable & get degraded more slowly by the enzyme hyaluronidase than non cross linked hyaluronic acid

• The frequency of injections can be reduced

Sodium Hyaluronate


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Dermal filler application to remove wrinkles & fill out naso-labial folds

Before & after dermal filler treatment

Sodium hyaluronate


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Biodegradable & eco-friendly

Sodium hyaluronate is completely natural

Produced by bacterial fermentation

“Green technology”