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Boala pruriginoasaBoala tremuratoare
- depresie- incoordonare in mers
- prurit intens
Cauza ANTC
I descriere – sec XVIII
Cuille si Chelle 1936 – 1940: inoculabilitate si
transmisibilitate la oaie si capra
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Epidemiologie:- raspandire geografica universala
Receptivitate: ovine si caprine 3-4 ani (chiar 12 luni) +
rase (Suffolk, Cheviot) + sensibilitate familiala
-determinism genetic alelele Sip sA si pA
-enzootica in efective: 2-5‰ (?)
Surse: majoritatea tesuturilor, excreta, pasuni, ape,
placenta, splina, lnn, amigdale, colon, SNC
Transmitere : verticala si orizontala
Transplacentar
0,5% - 1%→ 10%
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CLINIC
Lent, tipic, atipic- incubatie 1-6 ani, mortala….. ?
- tulburari de comportament
- tremuraturi (la «tremblante» fr)- prurit («scrapie» en)
- tulburari locomotorii
- slabire – cahexie
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F. debut – insidios, tulb comportament, agitatie,
ortopnee, apatie, agresiv, rar depresie
F. pruriginoasa: prurit dorso-lombar
Reflex pruriginos: coada, bucce m.post
Hiperestezie cu tremuraturi intermitente
F. cerebeloasa: tremuraturi muschi cap
“leganat”, .....
Ataxie, alearga trap/galop ebrios
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DIAGNOSTIC:
- histopatologic
- Western – Blot (ELISA)
- Electroforeza capilara- Imunohistochimic
Anatomopatologic
Exclusiv microscopic:
- glioza astrocitara
- rarefiere neuronala- spongioza prin vacuolizarea neuronilor
- absenta infiltratiei mononucleare
- rareori depozite amiloide in boala naturala
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COMBATERE SI PROFILAXIE
Profilaxie
Sacrificarea efectivelor suspecte
Prohibarea importurilor Excluderea proteinei animale din alimentatie
Vid sanitar la pasuni
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ENCEFALOPATIA TRANSMISIBILA A NURCILOR
1965 in USASursa incriminata: carne si organe de la oi infectate
Epidemiologie
Transmisibila prin muscatura si zgarietura, consum decadavre
Clinic: incubatie 1-2 ani, tulburari de comportament, anorexie,
slabire, incoordonare motorie, moarte in 1-6 saptamaniProfilaxie:- sacrificarea efectivelor suspecte
- igiena alimentatiei
BOALA CAHECTIZANTA A CERVIDEELOR1980 – la turma de cerbi captivi in Colorado si la elani
ENCEFALOPATIA SPONGIFORMA A PISICILOR
1990 – Bristol primul caz