Laboratory Evaluation of Reproductive Function:PREGNANCYdr. Arthur E. Mongan, M.Sc., Sp.PKModul-Kehamilan Semester 5FK UNSRAT MANADO2009

HYPOTHALAMIC-PITUITARY-OVARY AXIS

Key Points the complex interaction a variety of hormones ovary (ESTRADIOL, PROGESTERONE) pituitary (FSH, LH) hypothalamus (GnRH) placenta (HCG, ESTROGEN, PROGESTERON)

HUMAN MENSTRUAL CYCLE(CHANGES IN HORMONAL PATTERN)

Key PointsEARLY PREGNANCY IS MONITORED BY MEASURING SERUM HCG CONCENTRATIONS THE PATTERN OF DRAMATIC INCREASE IN HCG CONCENTRATIONS DURING THE FIRST TRIMESTER IS EXPECTED

Human Chrionic Gonadotropin

Key PointsTHE RISK FOR THE MOST COMMON BIRTH DEFECTS, NEURAL TUBE DEFECTS (NTDs), DOWN SYNDROME (DS) IS DETERMINED DURING THE EARLY SECOND SEMESTER BY SCREENING OF MATERNAL SERUM FOR LEVELS OF AFP, HCG, and UNCONJUGATED ESTRIOL (uE3)

Key PointsFETAL HEMOLYTIC DISEASE (ERYTHROBLASTOSIS FETALIS) IS MONITORED BY SPECTROPHOTOMETRICALLY ESTIMATING THE LEVEL OF BILIRUBIN IN AMNIOTIC FLUID

Key PointsTHE STATUS OF FETAL LUNG MATURATION IS ESTIMATED FROM THE EVALUATION OF PULMONARY SURFACTANT IN AMNIOTIC FLUIDSEVERAL METHODS, INCLUDING DETERMINATION OF(1)Lecithin / sphingomyelin ratio (L/S)(2)the microviscosity by fluorescence polarization

LABORATORY EVALUATIONOF MAJOR DISEASE STATES IN PREGNANCY

ERYTHROCYTESPREGNANCY PSEUDOANEMIAWHY??

REFERENCES:McPherson RA, Pincus MR. Henrys Clinical Diagnosis and Management by Laboratory Methods, 21st ed., Saunders Elsevier Co., Philadelphia USA, 2007.

2.Lee GR, Bithell TC, Foerster J, Athens JW, Lukens JN. Wintrobes Clinical Hematology. 9th ed., Lea & Febiger, Philadelphia USA, 1993.

3.Coulam CB, Page Faulk W, McIntyre JA. Immunological Obstetrics, WW Norton & Co., Inc. USA. 1992.

TIKMenerangkan mekanisme regulasi poros kelenjar hipotalamus-hipofisis-ovari terhadap fungsi reproduksi wanita dan perubahannya selama proses kehamilan dan persalinanMenyebut beberapa uji laboratorik rutin dan khusus yang berhubungan dengan proses kehamilan dan persalinanTIUMahasiswa dapat mengidentifikasi faktor-faktor yang berkaitan dengan proses kehamilan dan persalinan