Uwe Heiss, MSc. ETH, Disclosure:
Honest Placebo Pills Placebo App
Self-Tracking Apps
Founder of Track & Share Apps, LLC
Founder of Zeebo Effect, LLC
Chapter I
Placebo Terminology
Placebo Generations 1 – 2 – 3 Scienti4ic Method and Placebo Placebo Use Today
P -‐ Pure Placebo O -‐ Open Placebo B -‐ Branded Placebo
Examples p[‒] o[‒] b[‒]: Ancient remedies p[+] o[‒] b[‒]: The classical sugar pill p[‒] o[‒] b[+]: Drugs used off-‐label p[‒] o[+] b[+]: Drugs used on-‐label p[+] o[‒] b[+]: Placebos in FDA trials p[+] o[+] b[+]: Pure, open, branded placebo
Integrated Placebo
Chapter II
Placebos Work
Doctors trust placebos while facing a dilemma. News: Placebo without deception enhanced treatment.
Focus matters. Design works. Price works. Meaning works. Experience works. Adherence works.
Strength of the Placebo Effect Nocebo Effect
Chapter III
Placebo Value
Relief symptoms. Chronic Back Pain Acute Migraine Irritable Bowel Syndrome (IBS) Stress and Anxiety Depression
Permit self-‐healing. The Modern Healing Ritual
Enhance performance. Knee Function Chronic Fatigue Parkinson's ADHD Respiratory Function ED Cognitive Performance Athletic Performance
Nurture Well-‐being
Chapter IV
How Placebos Work
Placebos work on our mind. Expectation Conditioning Meaning Appeal
Neurobiological pathways link mind and body. Endorphins Dopamine Serotonin Cytokines Cortisol
Hacking into a Complex System: The Mind-‐Body
Chapter V
Placebo Manual for Patients
When does it make sense to try placebo? Keep it safe.
Who is likely to respond to placebo?
How to Design your Placebo Experience How to 4ind out if you respond to placebo. How to track your experience
Top 5 Ideas for Using Placebos
Chapter VI
Placebo Manual for Patient Care Providers Patients are open to placebos.
More Care Options Alleviate Side-‐effects from Medical Treatment Protect the Ef4icacy of Antibiotics Fine-‐tune Dosage Weaning-‐off drugs Customize Care
The Doctor's Placebo Effect. Tone of physician feedback Frequency of visits Consultation time Impression of physician Eliciting Expectations Of4ice environmentReview your use of placebos.
What are your placebo ethics? Can you provide more balanced care? Do you measure individual effects? What's your logic for using placebos?
Chapter VII
Beyond Placebo 3.0
More Ways to Well-‐being Exercising Hydration Sleep Skillful Eating Meditation Meaningful Life Healthy Environment