Клітинний цикл, апоптоз, аутофагія

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2. 3. 4. , , - (Cdks) , : - - - 5. 6. , ` - 7. -) 8. () - , , -- . - - , .- - - 9. 1977 . - 80- - 10. - -E1 19S c20S c-- 11. The Nobel Prize in Chemistry 2004 - 12. , , , 13. 14. 24 15. ( . apoptosis , ) , , : , , , , . 16. () +++- , , , , + - + - 10 12 1 + - - +++ 17. , - () ( ,, - , TGF- .), - ()- (, - , - .), - , , - ( - - ,, HTLV-1,2) - . 18. 19. Caspases (Cysteine-dependentaspartate-directedproteases) ! 20. - [. auto phagos ] , , 21. DIFFERENT TYPES OF CELL DEATH INCULTURE OF NEONATAL CARDIOMYOCYTESVisualization of living, necrotic and apoptotic cells with use of Hoechst 33342Visualization of autophagic cells with use of monodansylcadaverine 22. 23. 24. Duran A. et al. p62 is a key regulator of nutrient sensing in the mTORC1 pathway // Mol Cell. 2011 Oct 7;44(1):134-46. 25. mTOR +- ( )Jenna L. Jewell, Ryan C. Russell & Kun-Liang GuanAmino acid signalling upstream of mTOR Nature Reviews Molecular Cell Biology 14, 133-139 (March 2013) 26. Endoplasmic reticulum to nucleus signaling 27. Endoplasmic reticulum to nucleus signaling 28. (UPR)