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20171227_건강한네일을부탁해_네일숍유해물질프로젝트 보고서

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  • ()

  • 1.

    . 12

    . 32

    . 48

    2.

    (1)

    . 62

    . 66

    . 75

    (2)

    . 160

    . 164

    . 167

    (3) (FGI)

    . 212

    . FGI 218

    . 274

    3.

    . 294

    . 294

  • 1.

    .

    .

    .

    - ( , , , ) . -

  • .

    1.

    1-1. 12

    1-2. 13

    2. 19

    3.

    3-1.

    3-1-1) 20

    3-1-2) 21

    3-2.

    3-2-1) 22

    3-2-2)

    . , 22

    . VOCs 24

    3-2-3) VOCs 25

    3-2-4) 27

    3-2-5) DBP, DEHP 28

    3-2-6) Diphenyl phosphate 30

    .

    1.

    1-1. 32

    1-2. 33

    1-3. , , 36

    1-4. 39

    2.

    2-1. VOCs 42

    2-2. Biomonitoring

    . 44

    . DBP, DEHP 45

    . Diphenyl phosphate, DHPH 46

    . 48

  • [1] 13

    [2] 14

    [3] 16

    [4] 20

    [5] 21

    [6] TPP GCMS 23

    [7] TPP SIM 23

    [8] VOCs GC/MS 24

    [9] VOCs SIM 24

    [10] GC/FID 26

    [11] 26

    [12] HPLC/UV 28

    [13] 32

    [14] 33

    [15] 34

    [16] 36

    [17] DEP 37

    [18] 37

    [19] 38

    [20] GCMS 40

    [21] 41

    [22] VOCs 42

    [23] VOCs 43

    [24] ;

    47

    [25] ;

    47

    [1] 12

    [2] 21

    [3] OVM 3500 25

    [4] 29

    [5] DPHP 31

    [6] TPP 39

    [7] 45

    [8] DPHP 48

    [9] 1 50

    [10] 2 50

  • 12 ()

    . 13

    1.

    .

    1.

    1-1.

    1990 ,

    2013 5 ( , 20151)). (2013)

    , 2009 2013 5 1~3%

    [1].

    2013 6,803 1,689

    24.8% . 3,362 27.8%

    [1].

    1), , , . . , 2015. 25(4); 446-464.

    () 2009 2010 2011 2012 2013

    () 3,669 4,516 5,201 6,161 6,803

    () 7,842 8,914 9,832 11,239 12,104

    () - - - - 1,689

    () - - - - 3,362

    (2015)2) , , (),

    ,

    .

    4

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    (. 2015)3). 71.5% ,

    30 35.6% 40(25.7%), 20(21.8%) .

    20-30 .

    1-2.

    ,

    . .

    (2016)4)

    [2],

    2), , . . 2015.

    3). (nail care) . 2015. (http://economy.seoul.go.kr/archives/30111) 2017. 11.

    4)New York State, Department of Health. Review of Chemicals Used in Nail Salons. 2016.

    10,000

    15,000

    5,000

    0

    20102009 2011 2012 2013

    [1] ( : (2015) )

    [1] ( : , ) ((2015) )

    3,6694,516

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  • 14 ()

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    [2] ( : DOH NYS, 2016)

  • 16 ()

    . 17

    1.

    ,

    .

    .

    (2017)6) (Volatile Organic

    Compounds, VOCs) aceton, ethanol, isopropanol, butyl acetate, ethyl

    acetate Toluene TVOCs(

    ) .

    (2015)7) ,

    . 1A Formaldehyde, 2

    titanium dioxide, methyl t-butyl ether, vinyl acetate, hydroquinone, ethylene glycol mono-

    n-butyl ether hydroquinone, 1B

    n-butyl phthalate, 2 toluene .

    2015 8) ,

    .

    .

    VOCs 128

    ,

    .

    .

    7 .

    (2009)9) Dibutyl phthalate

    . 15 2 DBP

    DBP ,

    .

    6) . . , 2017. 27(1); 59-69.

    7), , , . . , 2015. 25(4); 446-464.

    8). . 2015.

    9). . 2009.

    . ,

    , ,

    , , , .

    Phthalate(),

    Formaldehyde() Toluene() Toxic Trio .

    .

    . Ford & Scott(2017)5)

    [3] . , (Dibutyl

    phthalate, DBP), (Paraben), (Triphenyl phosphate, TPP) 7

    .

    , , ,

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    ( )

    ,

    ,

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    ( ), ,

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    non- ,

    (DBP )

    ,

    5) Ford & Scott. A Critique of Risk Disclosure as the Solution for Minimizing Toxic Exposures in Pregnancy: The Case of

    Nail Salon Workers. 2017

    [3] ( : Ford & Scott, 2017)

  • 18 ()

    . 19

    1.

    2.

    .

    . ,

    ,

    . VOCs

    .

    , DBP DEHP, TPP ,

    .

    .

    , ,

    (, DBP, DEHP, TPP) .

    ,

    .

    ,

    .

    .

    ,

    .

    .

    Quach et al.(2015)10) (small for

    gestational age, SGA) (OR=1.39; 95% CI 1.08-1.78),

    (OR=1.28; 95% CI 1.10-1.50),

    (OR=1.59; 95% CI 1.20-2.11) .

    Hiipakka & Samimi(1987)11) 20 20 VOCs

    polymetacrylates ,

    OSHA PEL .

    Quach et al.(2011)12) 20 80 ,

    , .

    , ,

    .

    Roelofs et al.(2012)13) CO2 . 22

    8 , 73%

    .

    10) Thu Quach, Julie Von Behren, Debbie Goldberg, Michael Layefsky, Peggy Reynolds. Adverse birth outcomes and

    maternal complications in licensed cosmetologists and manicurists in California. Int Arch Occup Environ Health. 2015.

    88 ;823833

    11) Hiipakka D, Samimi B. Exposure of acrylic fingernail sculptors to organic vapors and methacrylate dusts. Am Ind Hyg

    Assoc J.(48) 1987 :230237

    12) Quach T, Gunier R, Tran A, Von Behren J, Doan-Billings PA, Nguyen KD, Okahara L, Lui BY, Nguyen M, Huynh J,

    Reynolds P. Characterizing workplace exposures in Vietnamese women working in California nail salons. Am J Public

    Health. 2011;101:S2716.

    13) Roelofs C, Do T. Exposure assessment in nail salons: an indoor air approach. International Scholarly Research

    Network Public Health, 2012.

  • 20 ()

    . 21

    1.

    3-1-2)

    , / .

    55, ,

    , , , , (/), (, /,

    ) [5].

    16 6 22

    6 4 10

    5 2 7

    3 3 6

    (/) 1 1 2

    1 1

    7 7

    N (%) 31 (56) 16 (29) 8 (15) 55 (100)

    :

    : ~

    3.

    3-1.

    3-1-1)

    (http://bit.ly/nail_workers,

    2017 11 29 ). 2017 8 1 9 22, 9

    5 29 4 . 52 , 17

    35 .

    , 30.2(23~45). 9 44

    20 26 .

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    [4].

    , N 35

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    , year 306

    , h 9.72.2

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    , ,

    , [2]. VOCs 8(Isopropyl Alcohol,

    Aceton, Benzene, Ethyl acetate, Toluene, p-Xylene, o-Xylene, Butyl acetate)

    , , 2 5, TPP

    (Diphenyl phosphate, DPHP) .

    .

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    DPHP , 70 .

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  • 22 ()

    . 23

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    3-2-1)

    (, ) , ,

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    . .

    , 14) .

    (CAS No.) , 15)

    .

    . (Substance of Very High Concern, SVHCs)

    (Carcinogen Mutagen Reproductive toxicant, CRM), (Persistant

    bioaccumulativeToxic substance, PBT), (Endocrine Disrupting Chemicals,

    EDCs) . , ,

    .

    3-2-2)

    . ,

    TPP 16)

    . 12 0.5g

    5 30 sonication . 2500rpm 15

    . 8:2(v/v) ,

    Benzyl Benzoate 100ppm .

    Auto Injector(AOC-20i, SHIMADZU, Japan) /(Gas

    14) : https://www.kcia.or.kr/cid/main.asp

    15): https://toxfree.kr/ ( )

    16). . 2016

    Chromatograph/Mass spectrometer; GCMS-QP2010 Ultra, SHIMADZU, Japan) SIM mode

    . GCMS SIM .

    EPA Phthalates Esters Mix(2000ppm, Supelco) Triphenyl phosphate

    . DMP, DEP, DBP, BBP, DEHP DNOP 0.67~9.76/,

    TPP 0.33~9.76/ . , R2 0.996~0.999 .

    7 ,

    DMP 0.56, DEP 0.56, DBP 0.73, BBP 0.88, DEHP