登革熱(Dengue fever)

1. 1 201407

2. 201407 2

3. 3 201407

4. 4 201407

5. 5 201407

6. 1 5,00050 6 201407

7. 2 1987 2002 5,33624119 7 201407

8. 8 // Flaviviridae Flavivirus RNA 201407

9. Arboviruses 201407 9 Disease Vector Host Distribution Disease Alphaviruses Chikungunya Aedes Humans, Monkeys Africa, Asia Fever, arthralgia, arthritis Eastern equine encephalitis Aedes, Culiseta Birds North and South America, Caribbean Mild systemic ; encephalitis Western equine encephalitis Culex, Culiseta Birds North and South America Mild systemic ; encephalitis Venezuelan equine encephalitis Aedes, Culex Rodents, Horses North, South, Central America Mild systemic ; severe encephalitis Flaviviruses Dengue Aedes Humans, Monkeys Worldwide, especially tropics Mild systemic; break- bone fever, DHF, DSS Yellow fever Aedes Humans,m onkeys Africa, South America Hepatitis, hemorrhagic fever Japanese encephalitis Culex Pigs, birds Asia Encephalitis West Nile encephalitis Culex Birds Africa, Europe, central Asia, North America Fever, encephalitis, hepatitis St. Louis encephalitis Culex Birds North America Encephalitis

10. 10 201407 3-814 15

11. 0 5 10 15 20 25 30 31 7+3 3 17+14 14 10 -1 5 7 17 15 812 7-17 314 201407 11

12. 12 201407

13. 201407 1 45 13

14. 14 201407

15. 15 201407 1500

16. 16 201407 CAB INTERNATIONAL 1997 Dengue and Dengue Hemorrhagic Fever (eds D.J. Gubler and G.Kuno)

17. 1 38 hemorrhagic manifestations leukopenia 17 201407

18. 2 10 plasma leakage 100 mmHg 20 mmHg 18 201407

19. non-structural protein 1 NS1 ()IgM IgG IgM IgG4 19 201407

20. 24 20 201407

21. 1% 20% [WHO] 5% 21 201407

22. 22 201407

23. 23 201407

24. 24 201312 * 2005 45,893 56,980 39,686 33,901 9,040 14,209 306 2006 42,456 68,532 38,556 37,101 16,669 3,127 1,074 2007 62,949 104,393 48,846 55,639 39,851 8,826 2,179 2008 89,626 96,451 49,335 39,620 9,542 7,032 714 2009 25,194 105,370 41,486 57,819 11,699 4,497 1,052 2010 116,947 128,831 46,171 135,355 12,500 5,364 1,896 2011 64,374 69,878 19,884 125,975 15,980 5,309 1,702 2012 78,063 86,026 21,900 178,644 42,362 4,602 1,478 2013 150,934 66,140 43,346 166,107 16,722 22,101 860 *

25. 25 201312

26. 1 26 201312 () 1987 527 1988 4389 1989 35 (16)(19) 1990 10 (0)(10) 1991 175 (149)(26) 1992 23 (4)(19) 1993 13 (0)(13) 1994 244 11(1) (222)(22) 1995 369 5 (329)(40) 1996 55 3 (20)(35) 1997 76 (19)(57) 1998 344 14(1) (309)(35) 1999 68 4 (42)(26) 2000 139 (113)(26) 2001 281 10(1) (227)(54) 2002 5388 241(19) (5336)(52) 2003 145 2(1) (86)(59) 2004 427 5 (336)(91)

27. 2 27 201312 () 2005 306 3 (202)(104) 2006 1074 19(4) (965)(109) 2007 2179 11 (2000)(179) 2008 714 4 (488)(226) 2009 1052 11(4) (848)(204) 2010 1896 18(2) (1592)(304) 2011 1702 20(5) (1545)(157) 2012 1478 35(7) (1271)(207) 2013 860 14 (596)(264)

28. 19872013 201312 28

29. 2005-2013 29 201312

30. 30 201312 2005-2013 81 97 67 44 174 463 127 62 23 11 166 389 41 46 41 31 113 272 48 45 14 15 100 222 32 18 10 8 33 101 17 12 7 1 54 91 9 3 12 3 34 61 9 9 7 1 22 48 13 11 2 11 37 3 1 7 8 19 6 6 12 8 4 1 5 21 39 394 308 191 119 742 1754

31. 31 201407

32. 32 201407

33. 33 201407

34. 34 201407

35. 35 201407

36. 36 201407

37. 37 201407

38. 5 38 201407

39. 39 201407

40. 2 2 40 201407

41. 1 41 201407

42. 2 42 201407

43. 3 (Communication for Behavioral Impact, COMBI) 43 201407

44. 44 201407

45. 45 201407

46. 46 201407

47. 47 201407

48. (Temephos) (Diflubenzuron) (Methoprene) (Pyriproxyfen) (Bacillus thuringiensis, serotype H-14) 48 201407

49. 49 201407

50. 2 50 201407 3 2

51. 51 201407 50-100 3 3-4

52. 52 201407 50, 611 20 125 10

53. 53 201407 100% = 100% = 100 = 100 = =

54. 1 54 201407

55. 2 55 201407 2 15 2 2

56. 56 201407

57. 57 201407 Ultra low-volume spray, ULV Thermal fog

58. 58 201407 2 2 0.2

59. 59 201407

60. 60 201407 2/ 15014 23 1 15014

61. 61 201407 128 A 2-5 B 6

62. 62 201407 2

63. 63 201407 1. 100 2. 2 3. 4. 5. 6. 100 7. 1. 2. 3. 4. 5. 6.

64. 64 201407 1. 2. 7 3. 4. 5. 100 6. 7. 7. 8.

65. 65 201407

66. 1 66 201407

67. 2 67 201407

68. 68 201407

69. 69 201407

70. 70 201407

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登革熱(Dengue fever)