The world leader in serving science Proprietary & Confidential

,

, 2015

-

2 Proprietary & Confidential

=

(a priori)

X

( ) )

= a priori x LR1* x LR2 x LR3

LR= likelihood ratio - -

3 Proprietary & Confidential

.

4 Proprietary & Confidential

5 Proprietary & Confidential

1. =

2.

3.

4.

KRYPTOR

6 Proprietary & Confidential

1100 68 ,

.

PAPP-A

Old 4267 mU/L 254 4,4%

Level J 3761 mU/L 1047 3,5%

Level N 1082 mU/L 1158 3,5%

Level C 112 mU/L 1185 4,4%

7 Proprietary & Confidential

1100 68 ,

.

Free

Old 37,4 ng/mL 288 3,3%

Level L 106 ng/mL 1104 3,2%

Level D 16,7 ng/mL 1201 3,1%

Level C 5,1 ng/mL 1203 3,9%

8 Proprietary & Confidential

UK NEQAS

UK NEQAS

- UK NEQAS

UK

9 Proprietary & Confidential

- UK NEQAS

10 Proprietary & Confidential

2003- 2015 = 3.0%

UK NEQAS: Free

Feb 2003-Feb 2015

11 Proprietary & Confidential

2003- 2015 = 3.1%

UK NEQAS: PAPP-A

Feb 2003-Feb 2015

12 Proprietary & Confidential

DSNEWS 10(1): 30-31

13 Proprietary & Confidential

UK NEQAS: PAPP-A

2003 2014: KRYPTOR BIAS 0.1% (-0.4 0.6%)

14 Proprietary & Confidential

UK NEQAS -

KRYPTOR BIAS PAPP-A Free

15 Proprietary & Confidential

-

16 Proprietary & Confidential

UK NEQAS

17 Proprietary & Confidential

PAPP-A

-

KRYPTOR

PAPP-A

18 Proprietary & Confidential

BRAHMS: UK NEQAS!

!

BRAHMS KRYPTOR

FMF 1999