03antibiotics r aerts

4TH MERIAL FORUM

HAVE WE GOT PCVD &

SWINE INFLUENZA UNDER

CONTROL?

Higher Health

Frans Dirven

Vet. Practice Lintjeshof

Nederweert, The Netherlands

2 2

Reduction of antibiotics in the Netherlands, field cases

Rob Aerts DVM Lintjeshof Netherlands

Agenda • 1 introduction

• 2 reduction of antibiotics; why? how much?

• 3 reduction of antibiotics; how? results

• 4 moment of consideration

• 5 conclusions

1 introduction;Lintjeshof practice • 25 vets/16 specialized in Swine, 4 locations covering

the Netherlands, 2 locations in Germany (1 in Belgium)

• The service we offer:

– Vet expertise /consultancy

– Diagnostic lab and monitoring

– Pharmacy with product display

5

6

Lintjeshof practice

• approximately 25 % market share in NL

• swine ( 80 % ) • cattle ( 8 % ) • poultry ( 7 % ) • companion Animals (5 %)

• 25 vets, 3 laboratory assistants • 14 Secretarial staff • MT (operational-,financial manager and

managing director) • Iso-nen certified

• 14 vets • 3 vets • 1 vet • 4 vets

• All Specialized

8 6/5/2012 lintjeshof 8

Pharmacy, operation and management

Vet practice and lab

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Vet. Pharma companies wholesalers

Veterinary clinic+ pharmacy Veterinary pharmacy Licence traders

Farmer

prescription Antihelmintics under prescription

Farmvet

Current situation • Farms are becoming bigger (1000-2000 sows),

small breeding farms disappear

• Productivity is going up to 30 piglets / sow / year

• Total piglet production is rising

• Producer is more dependant on export (large units up to 5000 sows)

• Family farms, closed herds ( 300- 500 sows, 2500 – 5000 fatteners) rather independent

Data

• 900.000 sows

• 7 million piglets exported Germany!

• Production cost piglet 25kg: 49 euro

• Per sow highest production of meat (kg)/year

(followed by Denmark and France)

• Production cost of 1kg porc: 1,46 euro

12

Total of farms decreasing, total animals pro farm increasing

Facts • Strong focus on costs

• Continuous system (many movement of pigs)

• Higher health difficult to obtain (many diseases)

• SPF difficult to maintain (swine density)

• No support for “megafarms”

• High usage of antibiotics (political statement)

• Highly dependant on export!!! Health is most important topic



• 3 reduction of antibiotics; how?


• 5 conclusions

2 reduction of antibiotics; why? how much?

• High usage of ab has become a political item

• Increasing resistance (MRSA,Klebsiella, E Coli)

• ESB-L issues…..

• Transfer of resistant bacteria/ genes

direct; poor hygiene

indirect; environment (soil,surface waters)

• vet held responsible for increase in usage…

presentatie f.dirven lintjeshof 16 6/5/2012 16

Volkskrant 2007

http://www.volkskrant.nl/binnenland/article1273787.ece/Antibiotica_voor_vee_snel_te_veel

17

Average daily doses per animal/year

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Antibiotic-resistance

Prevalence of MRSA

Moment of consideration

• How much reduction? 2008-2013: 50%

• Separation between vet practice and pharmacy?

• Vet is gatekeeper for animal and human health

• Curative use only, preventive use prohibited?

• Separation of human/ animal ab

(cephalosporines, quinolones banned since 1jan2012)

(ab for human use only and vice versa)

Agenda

Lintjeshof, 30 maart 2011

• 1 introduction

• 2 reduction of antibiotics; why? How much?



• 5 conclusions

reduction of antibiotics; how? results

• Introducing ddy

• Introducing vetcis (databank)

• Introducing SDA (vet drugs authority)

• Benchmark farmers and vets (penalties?)

• Separation vet pharmacy and practice (pervert)?

• Income of vet independent margin on drugs

vetcis

reduction of antibiotics; how? results

• Prudent use (dosage, days, diagnosis)

• Alternatives : MCFA’s, probiotics , immune stimulating products, vitamines, antioxydantia, mycotoxin binders

• Vaccines (circo, myco, prrs, flu, parvo….)

• Symptomatic therapies in case of acute illness ( nasa, metacam, paracetamol)

• Focus on higher health

Strategy to higher health

• Improvement veterinary strategy

• Improvement management at farmlevel

• Improvement feed strategy

Improvement veterinary strategy No more “old school”:

• lots of emergency therapies

• farewell and entry medications

• vaccination at entry fattening unit because of mistrust between breeder, fattener and trader

• Many combinations of ab

We are producing food, not only kg of meat

Improvement veterinary strategy • Proper diagnosis!! Define the primary agent

• Vaccinate against primary diseases

(prrs, flu, circo, mhyo, parvo)

• Antibiotics just for secondary infections

(pasteurella, app, glässer….strep suis???)

• Painkillers in case of fever/ severe illness to increase feed/water intake

• Blood monitoring for diagnostics and herd-health-passport

• Improving of general farm management

36 6/5/2012 lintjeshof 36

Improvement of veterinary strategy

Prevention by vaccination:

• New vaccins (mycoplasma, flu, prrs, circo, glasser etc) combi vaccins

• Top down (young gilts, sows,piglet, fatteners)

• Decrease of antibiotics (kg) is the objective and improvement of technical results

• Higher healthstatus (prrs neg piglets)

• Return on investment !!!(proper diagnosis)

Improvement of veterinary strategy


Painkillers

• Symptomatic, mostly viral infections

• Less anorexia (dg fatteners)

• Reducing fever (most sows abort due to fever)

• Total health at higher level

• Less secondary infections ( combination management)

• If so, individual antibiotic use.

Serological monitoring by spc

Fieldcases antibiotic reduction

Case 1:

• Closed herd (500 sows, 4000 fatteners)

• Problems fatteners: diarrhea, runts, high mortality (5-6%), no lung problems

• Tiamutin used on regular basis

• Brachyspira-, salmonella-, pia+

• Bloodsampling and necropsy: high viral load pcv2

• Vaccination against pcv at 3 weeks of age

Results case 1

0,0

10,0

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30,0

40,0

50,0

60,0

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5

6

7

8

Jan - April 09 May - Aug 09 Sept - Dec 09 Jan - April 10 May - Aug 10 Sept - Nov 10

mortality % Average number of Daily Dosage per animal year

before vaccination all vaccinated animals transition



Case 2

• Sow farm (expanding from 900-1800 sows)

• 30 piglets sow/year (weekly production)

• Positive on prrs and influenza

• Vaccination:

piglets: circo 3 wk, sows: prrs and influenza

• 2010 (august) reproductive problems (abortions, fever, reduced feed intake, 3% mortality)

• No effect antibiotics, only pracetam (fever)


Case 2

• PCR fetus: parvovirus- (vaccinated), prrs-, circo-

• Bloodsamples: csf-

• Bloodsamples: influenza, prrs, app, circo

• Extra influenza vaccination started no effect

diagnostics case 2

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buisnummer

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HI-

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Influenza no seroconversion

diagnostics case 2

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0,5

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S/P

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0,0

0,5

1,0

1,5

2,0

2,5

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S/P

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Prrs no seroconversion

diagnostics case 2

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S/P

rati

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buisnummer

0,0

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0,6

0,8

1,0

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1,6

1,8

2,0

2,2

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S/P

rati

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buisnummer

App no seroconversion

diagnostics case 2

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OD

buisnummer

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OD

buisnummer

Circo IgM/IgG seroconversion

Results case 2 • After 6 weeks increase of problems • No effect extra SIV vaccination or antibiotics • Lab results: herd vaccination circovac after 2 weeks strong improvement (until today) • Vaccination scheme: gilts: 3 weeks and before first insemination sows: at 10 weeks of gestation piglets: 3 weeks of age


Case 3

• The effect of the application of mono-lauric acid with glycerol mono-laurate in weaned piglets on the use of antimicrobials in sow herds.

• Effect against gram+ bacteria ( streptococcus, staphylococcus)

• Product used for 6 months in nursery feed

• Effect on use of trimethoprim/sulfa, amoxicillin

Results case 3; 34 farm with la/gml

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20

40

60

80

100

120

140

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34

dagdosering zeugen voor

dagdosering zeugen na

Results case 3; 37 farms without la/gml

0

50

100

150

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250

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37

dagdosering zeug 1e periode

dagdosering zeug 2e periode

Results case 3


• Significant reduction in antibiotic use on farms using LZ/GML

• De Snoeck1*, S., van der Wolf2 P.,, Swart2, W., Heiiman3, E., Ebbinge3, B.

• 1 Veterinary Practice Lintjeshof, Nederweert, The Netherlands

• 2 Animal Health Service, Deventer, The Netherlands

• 3 Daavision B.V., Oss, The Netherlands

0 1

-50

-20

10

40

Box and Whisker Plot

de

lta

DD

laur

62 cases


Case 4 • Breeding herd 800 sows , high health • Piglets: seronegative (prrs, app, mhyo, pia) monitoring every 4 months

• Vaccination: sow: prrs, influenza, ery/parvo, app, e.coli piglets: glässer, pcv2 • Problems in nursery (light coughing, low feedintake after

weaning, mortality 3%, high use of ab (tetracyclin, trim/sulf)

• Week 1+2 after weaning pracetam in feed

Results case 4 Product amount Period 1 Period 2

Doxycyclin 100% 1kg 2 2

Trim/sulfa 80/420 5kg 12 2

Ampicillin 100ml 204 114

Draxxin 50ml 23 18

Powerflox 100ml 30 12

Florkem 100ml 15 10

Oxytetracyclin 100% 5kg 17 0

ADD 46 7

Improvement of general farm management

• Very important, not only health-management also total farm-management

• Without good management every veterinary therapy is useless

• Labour hours will be decreasing (more hours to spent for other subjects such as fertility)

• Employees have a higher labour moral


Structural changes in housing systems; • continuous productionsystems vs fixed week production system (poultry) • no mixing up animals from different origins • animals of same age • all in all out • strictly 1 to 1 • multisite production

ADD fixed week production system

57


• Stock density!! Many farms +10-20%

• SPF monitoring system (Denmark)

• Eradication of diseases (auj, prrs, mhyo, app)

• New farms start SPF





• 5 conclusions

4 moment of consideration • vetcis: reduction about 32 % • Sda gives ddy (sows+piglets 20, fatteners 13) • No more preventive medication (poor management) • Discussion quinolones, cephalosporines (01-01-2012) • No antibiotic mixing at feedmill (01-09-2011) • Political discussion about split (vetclinic/pharmacy) • Veterinarian most involved person at farm (farmspecific healthplan, welfare, control zoonotic diseases and art 1 diseases) 1 to 1 contract with farmer.

• Income; margin drugs? and hourly fee ? Contract ? Sector? Ministry ?

tete

ten

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Challenge


• New decrease 20% (with swine sector)

• Veterinarian becomes “health” director at farmlevel

(1 on 1 relation) with help from government to act independant

• System higher health and pig pass

• Sustainable swine production

• More alternatives (vaccines, feed additives, antioxydantia, herbs, toxin binders...........)

• Partner for financial returns

Another challenge:

Big Challenge

TEAM LINTJESHOF

Threats?


• Therapeutic bandwidth

• Are certain problems without antibiotics kept under control (e.g. strep. suis)

• Unable to go to higher health (density of farms and animals)

• Cost price meat in W. Europe? International competition

• Is consumer willing to pay for better and safer meat ?

• Will the vet be sufficiently paid for advice to keep his quality and know how





• 5 conclusions

Conclusions • Profitability in swine production strongly influenced by

farm health status • Food producers (decrease of antibiotics) • Reduction of ab strongly depending on farm health

status • End 2012 50% ab reduction (32% is obtained) • Alternatives for antibiotics…………. • Strong improvement general management and sector

structure • In the end a higher return on investment at farmlevel • Swineproducers need to improve their competitiveness

Thank you for your attention

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Health & Medicine

03antibiotics r aerts