* . ()M A P L A C E N_P O W E RNANO EQUINE PLACENTA HYDROLYSATE EXTRACTS: : 10-0932183[347]

CONTENTSINTRODUCTION

; 2. 3. ()4. 5. L-Arginine6. Vitamin C7. 6.5ml 30vial

6.5ml 30vial 5ml 60vial

1. Introduction ,,,2. , , . 3. 1 . 4. (, , ) . .

KOSA

, DB In vivo,in vitro

-

- - - UNESCO - WHO -

- OO ( )- OO (, DB)- OO ( )- OO (, , , )- OO (, , , )- OO ( ) -

1.

2. ,

3.

4.

5. HACCP() , - ;

, (5% ) 4 (10% ) Retinol Nano encapsulation Powder Retinol , EGCG98% Nano encapsulation Powder EGCG98% EGCG VitaminC Nano encapsulation Powder C C 3 99% 99% , , () - ,

KOSA

, ,,

nano- Drug Delivery System 1.Crystallization 2.Synthetic 3.chromatography -in vivo in vitro - - ()

2.

(Placenta)(placenta) ? , .

. , cytokine Tyrosinase , (FGF)

347 . , .

. .

1-1. !

2. (,BSE) () . () . !

1-2. 3. .4. 121 1 . .

*

; cytokine (cytokine)

1. , 2 ! .1. 1 .2. 10 . . .

!

7.50 9.65 5.30 7.01 12.08 2.10 6.26 5.51 2.26 5.06 3.27 1.43 3.07 2.00 3.59 2.51 8.3586

1.8 2.922.451.2111.342.211.917.771.730.423.881.221.822.484.664.224.9156

** 5% sample . 2.

(mg/100g)(mg/100g)226.75416.51.5656.750.5251.155.27517.10.13250.555.826.72.911.750.00250.27.0519.3

5

( % (W/W))

* (Sialic Acid ) : * GAG (Glycosaminoglycan ) :

* (Uronic Acid ) :

* (Chondroitin) : .

* (Hyaluronic Acid) : . 1)

ProteinSialic acidGAGUronic acidChondroitinsulfateHyaluronicscid0.1550.00255.2720.1331.162.82

1. (Various Active Peptides) : B1, B2, B3, B6, B12, C, etc : (, ), : , (, GAG, ) : (Ca), (Na), (K), (P), (Mg), (Zn), (Fe) DNA (Nucleic Acids) .

, (cytokine) . , , .

2. . , , , , , , , , , , , , , . ! , .

3. (anti-aging) . .

.

4. ,

Tyrosinase .

,

, . ? Tyrosinase . , .

5. . ., (fibroblast) . , Fibroblast Growth Factors (FGFs; ) , -> !! .

6. (Allergens) (granules) . , (Allergy) .

., () (Atopic ermatitis) .

7. KOSA

( , 1 )

() , .

- () 1. .2. .3. . .

Sheet1

reserved-40064x1F

No (g) (kg)

1 150.00203

2 75.00201.5

3 75.00201.5

4 56.25201.125

5 56.25201.125

6 56.25201.125

7 93.75201.875

8 93.75201.875

9 93.75201.875

10 37.50200.75

11 37.50200.75

12 37.50200.75

13 37.50200.75

1437.50200.75

: , , ,

* 1

Sheet2

Sheet3

(Maca, Lepidium meyenii)(Maca) Lepidium meyenii, (59%), (10.2%), (2.2%) 3 . 2,000 .

, / .

[ ]

, [ / ]

B, E , , , , , , , / [ ]

, , , , , , , , , , , , , , / [ ]

, , , , , / /

/

=> => NO, cGMP [ ][ ]1. .

2. . . 1.

Kang et,al,. , 2008 , Maca epididymal sperm count( ) .

2.

/

L-arginine (L-) , L-. . . , .

3. L- NO(nitric oxide) . , NO .

Vitamin C ( C)

Vitamin C .

, carnitine() .

7.

(, )

(, )