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Focused Ultrasound
ldquoWithout health there can be no happinessrdquo
Focused Ultrasound Technology
Two Stories
Focused Ultrasound Foundation
Focused Ultrasound
Early stage revolutionary noninvasive therapeutic technology
Alternative or adjunct Surgery Radiation therapy Drug delivery
Transform treatment Benign and malignant tumors Metastatic cancer Parkinsonrsquos disease amp epilepsy Back pain hypertension
Early Stage
MR 30 years ago Unknown Revolutionized diagnoses Affects everyone
Focused Ultrasound today Unknown ldquoMedicinersquos Best Kept Secretrdquo As important to therapy as MR is to diagnoses In 10 years may affect everyone
Infancy Not science fiction Real today
Essential Tremor Treatment
Awake no anesthesiaNo incisions
No burr holesNo electrodesNo infection
No blood clotsNo brain damage
ldquoWithout health there can be no happinessrdquo
Focused Ultrasound Technology
Two Stories
Focused Ultrasound Foundation
Focused Ultrasound
Early stage revolutionary noninvasive therapeutic technology
Alternative or adjunct Surgery Radiation therapy Drug delivery
Transform treatment Benign and malignant tumors Metastatic cancer Parkinsonrsquos disease amp epilepsy Back pain hypertension
Early Stage
MR 30 years ago Unknown Revolutionized diagnoses Affects everyone
Focused Ultrasound today Unknown ldquoMedicinersquos Best Kept Secretrdquo As important to therapy as MR is to diagnoses In 10 years may affect everyone
Infancy Not science fiction Real today
Essential Tremor Treatment
Awake no anesthesiaNo incisions
No burr holesNo electrodesNo infection
No blood clotsNo brain damage
Focused Ultrasound Technology
Two Stories
Focused Ultrasound Foundation
Focused Ultrasound
Early stage revolutionary noninvasive therapeutic technology
Alternative or adjunct Surgery Radiation therapy Drug delivery
Transform treatment Benign and malignant tumors Metastatic cancer Parkinsonrsquos disease amp epilepsy Back pain hypertension
Early Stage
MR 30 years ago Unknown Revolutionized diagnoses Affects everyone
Focused Ultrasound today Unknown ldquoMedicinersquos Best Kept Secretrdquo As important to therapy as MR is to diagnoses In 10 years may affect everyone
Infancy Not science fiction Real today
Essential Tremor Treatment
Awake no anesthesiaNo incisions
No burr holesNo electrodesNo infection
No blood clotsNo brain damage
Focused Ultrasound
Early stage revolutionary noninvasive therapeutic technology
Alternative or adjunct Surgery Radiation therapy Drug delivery
Transform treatment Benign and malignant tumors Metastatic cancer Parkinsonrsquos disease amp epilepsy Back pain hypertension
Early Stage
MR 30 years ago Unknown Revolutionized diagnoses Affects everyone
Focused Ultrasound today Unknown ldquoMedicinersquos Best Kept Secretrdquo As important to therapy as MR is to diagnoses In 10 years may affect everyone
Infancy Not science fiction Real today
Essential Tremor Treatment
Awake no anesthesiaNo incisions
No burr holesNo electrodesNo infection
No blood clotsNo brain damage
Early Stage
MR 30 years ago Unknown Revolutionized diagnoses Affects everyone
Focused Ultrasound today Unknown ldquoMedicinersquos Best Kept Secretrdquo As important to therapy as MR is to diagnoses In 10 years may affect everyone
Infancy Not science fiction Real today
Essential Tremor Treatment
Awake no anesthesiaNo incisions
No burr holesNo electrodesNo infection
No blood clotsNo brain damage
Essential Tremor Treatment
Awake no anesthesiaNo incisions
No burr holesNo electrodesNo infection
No blood clotsNo brain damage
Uterine Fibroid
Pre-treatment
Uterine Fibroid
Focused Ultrasound Noninvasive no incision Conscious sedation Minimal discomfort Outpatient 1 day recovery No side effects Preserved fertility
Hysterectomy Major surgery General anesthesia Painful Hospitalization 6 weeks recovery Side effects No more children
Uterine Fibroid
Pre-treatment 9 months post-treatment
Breast CancerPre-treatment
Two weeks post treatment
What is Focused Ultrasound
How does it work
Marriage of Two Innovative Technologies
Focused ultrasound Treat tissue deep in body non-invasively
Marriage of Two Innovative Technologies
Magnetic resonance (MR) or ultrasound (US) imaging Identify and target tissue to be treated Guide and control treatment in real time Immediate confirmation of effectiveness
Focused Ultrasound The Principle
Analogous to a magnifying glass focusing rays of the sunhellip
Uterine Fibroid
Focused Ultrasound Noninvasive no incision Conscious sedation Minimal discomfort Outpatient 1 day recovery No side effects Preserved fertility
Hysterectomy Major surgery General anesthesia Painful Hospitalization 6 weeks recovery Side effects No more children
Uterine Fibroid
Pre-treatment 9 months post-treatment
Breast CancerPre-treatment
Two weeks post treatment
What is Focused Ultrasound
How does it work
Marriage of Two Innovative Technologies
Focused ultrasound Treat tissue deep in body non-invasively
Marriage of Two Innovative Technologies
Magnetic resonance (MR) or ultrasound (US) imaging Identify and target tissue to be treated Guide and control treatment in real time Immediate confirmation of effectiveness
Focused Ultrasound The Principle
Analogous to a magnifying glass focusing rays of the sunhellip
Uterine Fibroid
Pre-treatment 9 months post-treatment
Breast CancerPre-treatment
Two weeks post treatment
What is Focused Ultrasound
How does it work
Marriage of Two Innovative Technologies
Focused ultrasound Treat tissue deep in body non-invasively
Marriage of Two Innovative Technologies
Magnetic resonance (MR) or ultrasound (US) imaging Identify and target tissue to be treated Guide and control treatment in real time Immediate confirmation of effectiveness
Focused Ultrasound The Principle
Analogous to a magnifying glass focusing rays of the sunhellip
Breast CancerPre-treatment
Two weeks post treatment
What is Focused Ultrasound
How does it work
Marriage of Two Innovative Technologies
Focused ultrasound Treat tissue deep in body non-invasively
Marriage of Two Innovative Technologies
Magnetic resonance (MR) or ultrasound (US) imaging Identify and target tissue to be treated Guide and control treatment in real time Immediate confirmation of effectiveness
Focused Ultrasound The Principle
Analogous to a magnifying glass focusing rays of the sunhellip
What is Focused Ultrasound
How does it work
Marriage of Two Innovative Technologies
Focused ultrasound Treat tissue deep in body non-invasively
Marriage of Two Innovative Technologies
Magnetic resonance (MR) or ultrasound (US) imaging Identify and target tissue to be treated Guide and control treatment in real time Immediate confirmation of effectiveness
Focused Ultrasound The Principle
Analogous to a magnifying glass focusing rays of the sunhellip
Marriage of Two Innovative Technologies
Focused ultrasound Treat tissue deep in body non-invasively
Marriage of Two Innovative Technologies
Magnetic resonance (MR) or ultrasound (US) imaging Identify and target tissue to be treated Guide and control treatment in real time Immediate confirmation of effectiveness
Focused Ultrasound The Principle
Analogous to a magnifying glass focusing rays of the sunhellip
Marriage of Two Innovative Technologies
Magnetic resonance (MR) or ultrasound (US) imaging Identify and target tissue to be treated Guide and control treatment in real time Immediate confirmation of effectiveness
Focused Ultrasound The Principle
Analogous to a magnifying glass focusing rays of the sunhellip
Focused Ultrasound The Principle
Analogous to a magnifying glass focusing rays of the sunhellip
Focused Ultrasound The Principle
Multiple intersecting beams of ultrasound Focused with extreme accuracy (1 mm diameter) Target in body
bull Individual beams pass harmlessly through adjacent tissue
bull Profound effect at point of convergence
Thermal ablationHistotripsyDeliver drugsDissolve clots sonothrombolysis Radiation sensitizationDrug activity enhancementSonodynamic therapy Coagulate blood vesselsAmplification of cancer biomarkersImmunomodulationNeuromodulationVasodilationVasoconstriction Stem cell delivery
Effects at Focal Point
Variety of effects variety of disorders
Destroy Tissue Thermal Ablation
Heating any tissue to 130degF (56degC) for 1 second Denatures proteins 100 cell death normal and abnormal
Focal Drug Delivery
Deliver drugs in high concentrations Precisely where needed minimizing systemic toxicity
Lipid Microbubbles
Lipid Microbubbles
Chemotherapeutic agents genes growth factors
Microbubbles Injected
Distribution of Microbubbles
Drugs Released at Focal Point
Focused Ultrasound Procedure
Targeting
Planning
Treating
Confirming Uterine Fibroids
Brain Tumors
Essential Tremor
Focused Ultrasound vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary malignancies
100 cell death
Sharp margins
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Destroy Tissue Thermal Ablation
Heating any tissue to 130degF (56degC) for 1 second Denatures proteins 100 cell death normal and abnormal
Focal Drug Delivery
Deliver drugs in high concentrations Precisely where needed minimizing systemic toxicity
Lipid Microbubbles
Lipid Microbubbles
Chemotherapeutic agents genes growth factors
Microbubbles Injected
Distribution of Microbubbles
Drugs Released at Focal Point
Focused Ultrasound Procedure
Targeting
Planning
Treating
Confirming Uterine Fibroids
Brain Tumors
Essential Tremor
Focused Ultrasound vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary malignancies
100 cell death
Sharp margins
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Focal Drug Delivery
Deliver drugs in high concentrations Precisely where needed minimizing systemic toxicity
Lipid Microbubbles
Lipid Microbubbles
Chemotherapeutic agents genes growth factors
Microbubbles Injected
Distribution of Microbubbles
Drugs Released at Focal Point
Focused Ultrasound Procedure
Targeting
Planning
Treating
Confirming Uterine Fibroids
Brain Tumors
Essential Tremor
Focused Ultrasound vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary malignancies
100 cell death
Sharp margins
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Lipid Microbubbles
Lipid Microbubbles
Chemotherapeutic agents genes growth factors
Microbubbles Injected
Distribution of Microbubbles
Drugs Released at Focal Point
Focused Ultrasound Procedure
Targeting
Planning
Treating
Confirming Uterine Fibroids
Brain Tumors
Essential Tremor
Focused Ultrasound vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary malignancies
100 cell death
Sharp margins
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Lipid Microbubbles
Chemotherapeutic agents genes growth factors
Microbubbles Injected
Distribution of Microbubbles
Drugs Released at Focal Point
Focused Ultrasound Procedure
Targeting
Planning
Treating
Confirming Uterine Fibroids
Brain Tumors
Essential Tremor
Focused Ultrasound vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary malignancies
100 cell death
Sharp margins
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Microbubbles Injected
Distribution of Microbubbles
Drugs Released at Focal Point
Focused Ultrasound Procedure
Targeting
Planning
Treating
Confirming Uterine Fibroids
Brain Tumors
Essential Tremor
Focused Ultrasound vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary malignancies
100 cell death
Sharp margins
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Distribution of Microbubbles
Drugs Released at Focal Point
Focused Ultrasound Procedure
Targeting
Planning
Treating
Confirming Uterine Fibroids
Brain Tumors
Essential Tremor
Focused Ultrasound vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary malignancies
100 cell death
Sharp margins
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Drugs Released at Focal Point
Focused Ultrasound Procedure
Targeting
Planning
Treating
Confirming Uterine Fibroids
Brain Tumors
Essential Tremor
Focused Ultrasound vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary malignancies
100 cell death
Sharp margins
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Focused Ultrasound Procedure
Targeting
Planning
Treating
Confirming Uterine Fibroids
Brain Tumors
Essential Tremor
Focused Ultrasound vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary malignancies
100 cell death
Sharp margins
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Focused Ultrasound vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary malignancies
100 cell death
Sharp margins
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Sharp Margins
Treated
1 mm
Liver Brain
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
-
Global Development LandscapeConceptual Preclinical Anecdotal Pilot Pivotal
Other Approvals
FDA Reimbursement
Neurological Essential TremorParkinsonrsquos DiseaseNeuropathic PainBrain TumorsOCD EpilepsyStrokeHydrocephalusTrigeminal NeuralgiaAlzheimerrsquos DiseaseCancer PainDepression
MusculoskeletalBack PainOsteoid OsteomaOsteoarthritisSacroilitis
Oncological BoneProstate TumorsThyroidParathyroidBreast CancerPancreasSoft TissueLiverKidneyHead Neck CancerLung BladderColonEsophagus
CardiovascularHypertensionAtherosclerosisAtrial FibrillationSeptal Perforation
Miscellaneous Acute Tubular NecrosisObesityDiabetesGlaucomaBenign Prostatic HypertrophyUreterocele
Womenrsquos Health Uterine FibroidsUterine AdenomyosisBreast Fibroadenomas
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Essential Tremor
Parkinsonrsquos Disease
Neuropathic Pain
Uterine Fibroids
Uterine Adenomyosis
Breast Fibroadenomas
Breast Tumors
Prostate Cancer
Global Development Landscape
ReimbursementSparse Uterine Fibroids
Pain from Bone Metastasis
Regulatory FDA
Cancer Pain
Bladder Cancer
Colon Cancer
Esophageal Cancer
Depression
Regulatory Outside US
Clinical Trials Anecdotal Preclinical ConceptualThyroidParathyroid
Breast Tumors
Pancreatic Tumors
Liver Tumors
Parkinsonrsquos Disease
Soft Tissue Tumors
Uterine Adenomyosis
Breast Fibroadenomas
Osteoarthritis
Hypertension
Hydrocephalus
Alzheimerrsquos Disease
Atherosclerosis
Atrial Fibrillation
Septal Perforation
Trigeminal Neuralgia
Acute Tubular Necrosis
Benign Prostatic Hypertrophy
Head amp Neck Cancer
Lung Cancer
Ureterocele
ThyroidParathyroid
Pain from Bone Metastasis
Pancreatic Tumors
Liver Tumors
Soft Tissue Tumors
Osteoid Osteoma
Back Pain
Kidney Tumors
Brain Tumors
OCD
Kidney Tumors
Neuropathic Pain
Essential Tremor
Prostate Cancer
Epilepsy
Stroke
Obesity
Diabetes
Sacroilitis
Glaucoma
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Imagine the Future
Advances in technology Imaging Focused ultrasound Focal drug delivery
Undreamed-of applications
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Snake Oil Cure-all
Insert MR videos
Magnetic Resonance Imaging
Insert MR videos
Magnetic Resonance Imaging
Limitations
Traumatic Injuries
Scoliosis
Leukemia
Potential Impact on Millions of People
Urgent need widespread availability of focused ultrasound Saving time saving lives
Delay results in unnecessary death disability and suffering Countless individuals friends family you
Medical device development and adoption slow
Decades concept to adoption as standard of care
The Problem
Process Complicated and Inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
PatientsAcademic research sitesPrivate philanthropyDisease specific foundationsNIHVenture capital private equityIndustryFDAInsurersPatient advocacy organizationsMedical societiesTreatment facilitiesPhysicians numerous specialties
Organizations with Different Agendas
Technical and engineering
Awareness and acceptance patients and physicians
Cultural and turf issues
Financial
Regulatory
Reimbursement
Obstacles
Obscure
No roadmap examples or formulas
Obligated to invent
The Solution
The Challenge
There is nothing more difficult to take in hand more perilous to conduct or more uncertain in
its success than to take the lead in the introduction of a new order of things
Itrsquos all about the patients
saving time saving lives
Purpose of the Foundation
Millions of Lives Improved
AdoptionDevelopment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Potential Impact on Millions of People
Urgent need widespread availability of focused ultrasound Saving time saving lives
Delay results in unnecessary death disability and suffering Countless individuals friends family you
Medical device development and adoption slow
Decades concept to adoption as standard of care
The Problem
Process Complicated and Inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
PatientsAcademic research sitesPrivate philanthropyDisease specific foundationsNIHVenture capital private equityIndustryFDAInsurersPatient advocacy organizationsMedical societiesTreatment facilitiesPhysicians numerous specialties
Organizations with Different Agendas
Technical and engineering
Awareness and acceptance patients and physicians
Cultural and turf issues
Financial
Regulatory
Reimbursement
Obstacles
Obscure
No roadmap examples or formulas
Obligated to invent
The Solution
The Challenge
There is nothing more difficult to take in hand more perilous to conduct or more uncertain in
its success than to take the lead in the introduction of a new order of things
Itrsquos all about the patients
saving time saving lives
Purpose of the Foundation
Millions of Lives Improved
AdoptionDevelopment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Medical device development and adoption slow
Decades concept to adoption as standard of care
The Problem
Process Complicated and Inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
PatientsAcademic research sitesPrivate philanthropyDisease specific foundationsNIHVenture capital private equityIndustryFDAInsurersPatient advocacy organizationsMedical societiesTreatment facilitiesPhysicians numerous specialties
Organizations with Different Agendas
Technical and engineering
Awareness and acceptance patients and physicians
Cultural and turf issues
Financial
Regulatory
Reimbursement
Obstacles
Obscure
No roadmap examples or formulas
Obligated to invent
The Solution
The Challenge
There is nothing more difficult to take in hand more perilous to conduct or more uncertain in
its success than to take the lead in the introduction of a new order of things
Itrsquos all about the patients
saving time saving lives
Purpose of the Foundation
Millions of Lives Improved
AdoptionDevelopment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Process Complicated and Inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
PatientsAcademic research sitesPrivate philanthropyDisease specific foundationsNIHVenture capital private equityIndustryFDAInsurersPatient advocacy organizationsMedical societiesTreatment facilitiesPhysicians numerous specialties
Organizations with Different Agendas
Technical and engineering
Awareness and acceptance patients and physicians
Cultural and turf issues
Financial
Regulatory
Reimbursement
Obstacles
Obscure
No roadmap examples or formulas
Obligated to invent
The Solution
The Challenge
There is nothing more difficult to take in hand more perilous to conduct or more uncertain in
its success than to take the lead in the introduction of a new order of things
Itrsquos all about the patients
saving time saving lives
Purpose of the Foundation
Millions of Lives Improved
AdoptionDevelopment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
PatientsAcademic research sitesPrivate philanthropyDisease specific foundationsNIHVenture capital private equityIndustryFDAInsurersPatient advocacy organizationsMedical societiesTreatment facilitiesPhysicians numerous specialties
Organizations with Different Agendas
Technical and engineering
Awareness and acceptance patients and physicians
Cultural and turf issues
Financial
Regulatory
Reimbursement
Obstacles
Obscure
No roadmap examples or formulas
Obligated to invent
The Solution
The Challenge
There is nothing more difficult to take in hand more perilous to conduct or more uncertain in
its success than to take the lead in the introduction of a new order of things
Itrsquos all about the patients
saving time saving lives
Purpose of the Foundation
Millions of Lives Improved
AdoptionDevelopment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Technical and engineering
Awareness and acceptance patients and physicians
Cultural and turf issues
Financial
Regulatory
Reimbursement
Obstacles
Obscure
No roadmap examples or formulas
Obligated to invent
The Solution
The Challenge
There is nothing more difficult to take in hand more perilous to conduct or more uncertain in
its success than to take the lead in the introduction of a new order of things
Itrsquos all about the patients
saving time saving lives
Purpose of the Foundation
Millions of Lives Improved
AdoptionDevelopment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Obscure
No roadmap examples or formulas
Obligated to invent
The Solution
The Challenge
There is nothing more difficult to take in hand more perilous to conduct or more uncertain in
its success than to take the lead in the introduction of a new order of things
Itrsquos all about the patients
saving time saving lives
Purpose of the Foundation
Millions of Lives Improved
AdoptionDevelopment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
The Challenge
There is nothing more difficult to take in hand more perilous to conduct or more uncertain in
its success than to take the lead in the introduction of a new order of things
Itrsquos all about the patients
saving time saving lives
Purpose of the Foundation
Millions of Lives Improved
AdoptionDevelopment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Itrsquos all about the patients
saving time saving lives
Purpose of the Foundation
Millions of Lives Improved
AdoptionDevelopment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Purpose of the Foundation
Millions of Lives Improved
AdoptionDevelopment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Overview
Founded 2006 Catalyst to accelerate the development and adoption of FUS
Charlottesville based global impact
Tax exempt high performance entrepreneurial Market driven action and results oriented
Essence of activities Foster collaboration Knowledge create aggregate share
Model Venture philanthropy social entrepreneurship Private funding bridges gap between research amp treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Unique Hybrid Organization
Device platform technology
Variety of clinical indicators
Fulfill multiple roles
Research amp Education
Foundation
Medical amp Scientific Society
Patient Advocacy
Organization
Patient Support
Organization
Manufacturers Trade
Association
Focused Ultrasound Foundation
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Vision
Focused Ultrasound Improve quality of life and longevity Millions of patients worldwide Serious medical disorders Shortest time possible
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Mission
Accelerate development of new applications Fulfill unmet critical medical need Superior to best current therapies Reimbursable Widely available as standard of care
Accelerate adoption as standard of care
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Culture
Patient centric Uncompromisingly passionately obsessively committed to rapidly
improving quality of life
Catalytic small nimble potent
Reputation contagious enthusiasm and energy Instill in others enthusiasm and energy to precipitate change
Entrepreneurial Create reality from imagined future through human action Accomplishments exceed assets available
Pioneering
Pursuit of excellence Hard work risk taking innovation
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Strategic Focus
Its all about the patients saving time saving lives Litmus test of actions and expenditures
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Medical societies
Disease specific foundations
Venture capital private equity
Positioning Nexus of Organizations
Academic research sitesPatientsPrivate philanthropy
NIH
Industry
FDA
InsurersPatient advocacy organizations
Treatment facilities
Physicians numerous specialties
Academic research sites
Patients
Private philanthropy
Disease specific foundations
NIH
Venture capital private equity
Industry Insurers
Patient advocacy organizations
Medical societies
Treatment facilities
FDA
Physicians numerous specialties
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Currency and Incentives
Reputation trusted independent unbiased 3rd party
Contagious passion and enthusiasm
Information
Funding
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Activities
Influence direction
Foster collaboration
Change behavior and policy
Create knowledge clinical evidence best practices amp standards
Cultivate the next generation
Convene the community
Collect and disseminate information
Increase awareness communications
Overcome barriers
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Influence Direction
Define areas of clinical benefit
Prioritize indications
Market oriented approach Segment to achieve natural advantage Pick battles Rapid success
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Foster Collaboration
Rapidly achieve a critical mass of effort and knowledge
Approach Stimulate innovation Leverage intellectual capital Coordinate activities avoid duplication
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Change Behavior amp Policy
Amalgamate stakeholders into a cohesive ecosystem Patient centric Sense of urgency
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Develop Evidence of Safety Efficacy
Organize conduct and fund research
Niche translational application gt discovery Preclinical clinical technical High risk early stage broad impact
Iconoclastic model Collaboration vs individual glory Patient centric vs investigator centric Commercially successful products vs publications grants promotion
Programs tightly managed milestone driven External award investigator initiated
bull Competitive peer reviewed Internal Foundation initiated
bull Brain liverbull Contracts with academia industry
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Establish Best Practices Set Standards
Research training patient care
Centers of Excellence multidisciplinary luminary sites Showcase for technology Venue for collaboration
Partnership of academia industry and the Foundation
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Centers of Excellence
UVA Focused Ultrasound Center Partnership
University of Virginia Commonwealth of VA FUS Foundation InSightec and GE
Institute for Cancer Research London Partnership
Royal Marsden Hospital FUS Foundation Philips Medical
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Cultivate the Next Generation
Educate clinicians and scientists
Fund fellowships and internships
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Convene the Community
Organize and fund meetings symposia workshops Exchange knowledge and ideas Foster collaborations and partnerships
Foundation Organized
Foundation Supported
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Collect and Disseminate Knowledge
Website
Newsletter
Journal
Collaborative Network
Social Media
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Website ndash fusfoundationorg
Encyclopedia of Focused Ultrasound
Source of information Comprehensive Trusted Up to date
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Newsletter
Published monthly
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Journal
Online open access peer reviewed Partnership with International Society for Therapeutic Ultrasound
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Collaborative Network
Inventory updated quarterly on website Laboratory research sites investigators and projects Clinical research sites Commercial treatment sites Manufacturers
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Social Mediafacebookcomfocusedultrasound
FUSFoundation
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Increase Awareness Communications
Inform stakeholders heat up environment advance field Awareness events Media relations
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Media Relations
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Media Relations (cont)
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Media Relations (cont)
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Overcome Barriers
Regulatory partner with FDA bridge not a barrier Pathway for new indications preclinical amp clinical studies
Reimbursement obtain coverage amp payment Evidence of safety efficacy cost Patient advocacy Physician advocacy
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Strategy
Leverage capital Cofunding and funding indirect costs royalties
Best in class management practices
Transparency accountability Continuous quality improvement policies procedures systems
Align vision mission strategy organization culture resources Prime the pump
Engage Foundations Government Industry VCs Assume functions of Foundation
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Organization
Flat flexible responsive to market and technology shifts
17 Athletes A-players Unbounded highly intelligent highly educated Healthcare professionals with over 140 years of experience 3 PhDs 3 MBAs 2 MDs Interns
Organized in teams
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Portfolio of Programs
Research
Collaborative network
Educational fellowships
Meetings symposia workshops
Centers of Excellence
Regulatory
Reimbursement
Communications
Website
Newsletter
Online open-source journal
Accelerate development and adoption
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Board of Directorshellipactive engaged passionate
Neal F Kassell MD Chairman Focused Ultrasound FoundationProfessor Department of Neurosurgery University of Virginia
Lodewijk JR de Vink Founding Partner Blackstone Health Care Partners
Dorothy N BattenFormer Director Landmark Communications
S Morry Blumenfeld PhDFounding Partner Meditech Advisors Management
Eugene V FifeFounding Principal Vawter Capital
John R GrishamAuthor
Daniel P Jordan PhDPresident Emeritus Thomas Jefferson Foundation Inc
Frederic H Moll MDCo-founder Intuitive SurgicalCo-founder and Executive Chairman Hansen Medical
Steve H RusckowskiCEO Quest Diagnostics Former CEO Philips Healthcare
Edward D Miller MDFormer CEO Johns Hopkins Medicine
Andrew C von Eschenbach MDPresident Samaritan Health Initiatives
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Academic and Corporate Relationships
S Morry Blumenfeld PhD InSightec Shareholder
Neal F Kassell MD InSightec Shareholder UVA Faculty Member
Andrew C von Eschenbach MD Histosonics Director and Shareholder
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
CouncilPurpose
Harness goodwill increase awareness
Members Passionate enthusiastic advocates
bull Amanda Megargelbull Michael Milkenbull Paula Newcombbull Wyndham G Robertsonbull Mary Lou Seilheimerbull Alice H Siegel bull Aaron Stern MD PhDbull Howard amp Fredi Stevensonbull Jack Syerbull The Honorable Nicholas F Taubmanbull Kitchie Tollesonbull Linda K Zecher
bull Jane P Batten (Co-chair)bull Charles H Seilheimer Jr (Co-chair)bull John B Adams Jrbull Ellen Blockbull Edgar M Bronfman Srbull Thomas N amp Nancy J Chewning bull Norwood amp Marguerite Davisbull Diane Hellerbull Cecelia S Howellbull Dean L Kamenbull Robert Khayat PhDbull Shirley Lin PhD
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Resources ndash Financial Capital
Committed to date $54 million 62 from Individuals 24 from CorporationsOrganizations 10 from Government 3 from Foundations
Next 3 years invest additional $25 million Research Fellowships Centers of Excellence Regulatory amp Reimbursement Symposium Website Newsletter Journal
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Fund Raising Model
Patients are impatient
Target venture philanthropists Rapid decisions Results oriented Staying power Substantial capacity (value every dollar every donor)
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Value Proposition
Once in a lifetime opportunity Investment with extraordinary return Social not economic
Big idea compelling story noble cause
Perfect timing
Best in class management practices
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Results ndash Accelerating Adoption
Magic moment in evolution Opportunity to make a difference
Early stage Small investment = large impact
No major theoretical or technical barriers Development gt Discovery
Brute force application of $ enormous progress
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Accelerating Development and Adoption
2020 +$65 million2022 +$50 million2024 +$35 million 2026 +$20 million2028 +$5 million20302013
Millions of Lives Improved
AdoptionDevelopment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Itrsquos all about the patients Saving time Saving lives
Itrsquos all about the patients
Saving time Saving lives
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Focused Ultrasound Manufacturers
Acublate SJTU SUNTEC
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Research and Commercial Treatment Sites
140+ Research sites
380+ Commercial treatment sites
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
87
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
88
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
89
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
90
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
91
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
92
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
93
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
94
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Global Development Landscape
Q3 2013
Reimbursement
FDA
Other Approvals
Pivotal
Pilot
Anecdotal
Preclinical
Conceptual
14
2
22
14
4
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
14
Dissolve Bloodclots Sonothrombolysis
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
24
Dissolve Bloodclots Sonothrombolysis
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
34
Dissolve Bloodclots Sonothrombolysis
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
44
Dissolve Bloodclots Sonothrombolysis
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Procedure Targeting
Structures to be avoided
Region to be treated
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Procedure Planning
Automatic planning
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Procedure Treatment
Temperature measurement
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Procedure Guidance
Move to next target
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Procedure Confirmation
Pre treatment
Post treatment
Treatment plan
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Internship Program
Back to Activities Slide Back to Organization Slide
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Procedure Targeting
Structures to be avoided
Region to be treated
14
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Procedure Planning
Automatic planning
Manual adjustment
24
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Procedure Treatment
Real time guidance
Temperature measurement
Adjust treatment parameters
34
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Procedure Confirmation
Confirmation of effectiveness
Retreat if necessary
44
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Pre-treatment
15
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Targeting
25
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Planning
35
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Treatment
45
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Post-treatment Confirmation
55
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Sonication size
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
116
Unique
Accelerate development of device
Platform technology Multiple mechanisms of action Variety of medical disorders
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
117
Patient Support Organization
Advocacy Group Grass Roots Increase Awareness
bull Patientsbull Physiciansbull Insurers
Facilitate Reimbursement
Fibroid Relief Prototype
FR Website ndash 71000 visitors since January 2009
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
118
Team
Jill Roberts
Whitney Robertson Mary Rose Serafini
John Snell PhD
Interns
Mark Adcock
Rachel Browning
Matt Eames PhD
Jessica Foley PhD
Arik Hananel MD MBA BsCs
Melissa Healy
Sara Horton
Heather Huff-Simonin MBA
Robin Jones
Neal Kassell MD
Susan Klees
Pamela Minetti MBA
Dave Moore MSc
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Potential Impact Urgent Need
Millions of People
With theFoundation
Without theFoundation
2000 2010 2020 2030
Cumulative adoption
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
120
Use of Funds
Research $9 million Meetings Symposia Workshops $1 million Fellowships $1 million Centers of Excellence $1 million Reimbursement Initiative $1 million Core Programs $7 million
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
121
Research
External Awards $2 million
Parkinsonrsquos Disease $24 million
Brain Tumors $850000
Pancreatic Cancer $250000
Liver Cancer $250000
Breast Cancer $600000
Stroke $600000
Epilepsy $500000
Brain Technology $800000
Back Pain $500000
$9 million
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
12213
Management Practices
Highest standards not-for-profit for profit Best practices policies processes systems Continuous Quality Improvement People
Strategic Plan Reviewed and updated frequently Acting gt studying and planning
Culture Entrepreneurial market driven results oriented Patient centric Itrsquos all about the patients
Operating plan and program management Updated annually quarterly weekly
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
12323
Management Practices
Governance Articles of incorporation bylaws Board of Directors represent all stakeholders Audit amp compensation committees Legal review
Finance Monthly reporting with audit committee review External audit of annual financials and 990 Annual 501(c)(3) tax status review Prudent investment policy Comprehensive insurance coverage
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
12433
Management Practices
People Philosophy lsquoArsquo players athletes Quarterly performance review against objectives Biannual external compensation review Structured hiringtermination process Employee handbook
Research awards and contracts Contracting legal and sponsored program expertise Peer reviewed research advisory committee Competitive program funding committee Monitoring milestones progress reports payments
IT Infrastructure Backups security redundancy
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
125
Use of Funds
Research $96 million Fellowships $14 million Centers of Excellence $41 million Communications $36 million Reimbursement $18 million Miscellaneous $400000 Development $22 million
$23 million
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
12613
Individual Donors (updated 91912)
Anonymous
Bob and Glorie Bailie
Baker Construction Group
Aimee and Frank Batten Jr Foundation
DN Batten Foundation
Frank and Jane Batten
Mr and Mrs David A Beach
Anson and Debra Beard
The Bernstein Law Firm LLC
Ms Lois Berry
Birdsall Family Fund
Ellen and Ronald Block Family Foundation
Dr and Mrs S Morry Blumenfeld
Rich and Roxanne Booth
Charles R Bronfman
Edgar M Bronfman and Jan Aronson
Peter and Nancy Brooks
Scott Byron and Company Inc
Phebe Cambata
The Caruthers Foundation
Mr and Mrs Norton E Cater
Mr and Mrs John Chamales
Roy R Charles Charitable Trust
Derwood and Johanna Chase
Tom and Nancy Chewning
Christian Broadcasting Network Inc
Moffett and Dupre Cochran
Mr and Mrs Victor M Dandridge Jr
Mr and Mrs Terrence D Daniels
Mr and Mrs John Stewart Darrell
Mrs Margareta CH Douglas
Mrs Francis Dulaney
Joan and Barry Elman
Mr and Mrs Albert D Ernest
Fibroid Foundation
Eugene V Fife Family Foundation
Bruce D Fisher
Margaret and Thomas Flynn
Penny and John Freund
Mr and Mrs Donald Geller
Struthers and Frederick Gignoux
Mark and Judy Giles
Leslie and Richard Gilliam
Mr and Mrs Donald Goldsmith
Ms Audrey Gould
Julann Griffin
Marge and Joe Grills
Mr and Mrs Eugene R Hack Jr
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
127
Individual Donors (updated 91912)
Jim and Sue Haden
Carolyn Hadesman and Family
John A Hartford Foundation Inc Matching Gift Program
The Hassenfeld Foundation
Diane and David Heller
Herndon Foundation
Mary Buford and Frederick P Hitz
The Joseph M and Lisa B Hogan Charitable Fund
Ulrike Hoffmann-Burchardi and Dirk Willes
Horton Foundation Fund in CACF
The Horwich Family Foundation
Mr and Mrs Robert M Huff
Chad D Inman
Dean Johnson
Mr Thomas NP Johnson III
Lou and Dan Jordan
Drs Neal and Lee Kassell
Marcia and Jonathan Kean
The Keeley Family Foundation
The Kellogg Organization Inc
Mr and Mrs Donald A King Jr
Mr and Mrs Douglas M Kinney
Mr James B Klutznick
Mrs Delores J Kuberka
Mr and Mrs Fritz R Kundrun
Diana Levin
Lawrence and Carol Levy
Dr Stanley H Levy
John L Lewis IV
Mr and Mrs Harvey L Lindsay Jr
Terry J Lockhart
Mr and Mrs John Lucey
St Lukersquos Hospital
John and Dudley MacFarlane
Chrisanne Mannion
Paul and Diane Manning
Jill Kiersky and Andrew Marcus
Mr and Mrs Donald Mazzoni
Janice McArdle Cancer Research Foundation
Patrick McCarthy
Melville Foundation
Methodist Hospital
Milken Family Fund
Mitford Childrenrsquos Foundation
Frederic Moll
Mr and Mrs Victor A Morgenstern
Thos Nelson Jr Initiative of the Community Foundation
Serving Richmond and Central Virginia
Paula and Rob Newcomb
Dick and Judy Nunley23 127
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
128
Individual Donors (updated 91912)
Joy Marie Polefrone
Prince Charitable Trusts
Dr MG Pat Robertson
The Robertson Foundation
Wyndam Robertson
Mr and Mrs Thomas C Rodeno
Felicia W Rogan
Madison Rogers
Harry and Ady Rosenberg
Mr and Mrs Charles M Rotgin
Steve and Deborah Rusckowski
Mr Raymond L Rusnak
Cari and Michael Sacks
The Adler Schermer Foundation
Valerie Beth Schwartz Foundation
Mr and Mrs Charles H Seilheimer Jr
Linda Rae Sher
Rick and Sherry Sharp The Community Foundation
Serving Richmond and Central Virginia
Dr James A Shield Jr
Alice H Siegel
Mr and Mrs Thomas A Silberman
Jane-Ashley and Peter Skinner
Albert H Small
The Eddie and Jo Allison Smith Family Foundation Inc
Oscar F SmithMarjorie Smith Charles Charitable Fund of
the Community Serving Richmond and Central Virginia
Robert H Smith Family Foundation
Mr and Mrs Francis M Stanis
Barbara and Cyrus Sweet III
Virginia and John Syer
Fay Davis Taylor In Memory of Bertrand L Taylor III
Sandra Thomas
Jane Tolleson
Ms Cecile Trop
Sarah Beck and Wojtek Uzdelewicz
Eleanor Cameron Van Clief Foundation
Mrs Faith Van Clief
Sheri Waddell
Mr and Mrs Herbert S Wander
Mark Warner and Lisa Collis
The Watterson Foundation
R Ted and Sheila Weschler
Custis Westham Fund of the Community Foundation
Serving Richmond and Central Virginia
Jane Woldenberg Family Foundation
Laurie and Bruce Zessar
Michael Zoller Family Philanthropic Fund
33 128
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
129
Corporate Donors and Sponsors
Abbott Laboratories
Cooley Godward Kronish
Crutchfield Corporation
EDAP
Elbit
Elekta
GE Healthcare
IGT
Imasonic
InSightec
International Society for
Therapeutic Ultrasound (ISTU)
JJA Instruments
JP Morgan
The Kellogg Organization Inc
Meditech Advisors
Methodist Hospital
Microsoft
Ogilvy Public Relations
Philips Healthcare
Siemens
St Lukersquos Hospital
Supersonic Imagine
Theraclion
University of Virginia
Varian Medical Systems Foundation
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Process complicated and inefficient
Technology RampD
Pre-clinical proof of concept
Design engineering
manufacturing
Evidence safety efficacy cost
IP generation and protection
Regulatory approval
Marketing sales support
Insurancereimbursement
Physician andScientist education
Patientadvocacy
Physicianadvocacy
Training andcredentialing
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Uterine Fibroids Approved FDA 2004 CE 2003
before treatment
planning
post-treatment
Pain Palliation of Bone MetastasesPatient with osteolytic breast cancer metastasis at right iliac bone
Pain score of 55 before treatment reduced to 0 at 3M follow up
Note At 3M new bone formation and thickening
of cortical layer in treatment area
CT Before Treatment
Prostate Cancer - Transrectal
Prostate Cancer - Transurethral
Breast CancerPre-treatment
Two weeks post treatment
Liver Tumors
post treatment dose maps (in blue)
and post treatment T1W C
Facet RhizotomyFocused ultrasound energy treats in the same locations as RF ablation
Neuropathic Pain ndash Zurich Research
Neuropathic Pain ndash Zurich Research
Brain TumorsAccumulated thermal dose
at end of treatmentDiffusion weighted image
immediately after treatmentT1w contrast enhanced image
immediately after treatment
140
Capsulotomy for OCD
FUSF
Focused Ultrasound Foundation
FUSF
Focused Ultrasound Foundation
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