H7N9 in China 2

H7N9 　 AVIAN INFLUENZA VOL.2

新潟大学大学院　医歯学総合研究科　国際保健学分野　

( ～ 2013.4.26)

Division of International Health　 (Public Health)Graduate School of Medical and Dental Sciences, Niigata University

H7N9 ウイルス遺伝子の特徴• HA 遺伝子はアヒル（ H7N3) 、 NA は野鳥の(H7N9) 、内部遺伝子はニワトリの（ H9N2)

• 二度大きな遺伝子組み換えが起こったと考えられる (1) A/Shanghai/1/2013

(2) A/Shanghai/2/2013 clusters • 低病原性　 HA 遺伝子の開裂部位に塩基性配列が欠

如している• HA 遺伝子に哺乳類へ適応する変異 : Q226L/I と T160A

• PB2 に哺乳類の体温に適応する変異 : E627K と D701N


• Ｈ７セグメント：浙江省の鴨群と韓国の野鳥群から分離• Ｎ９セグメント：韓国の野鳥 (wild bird) から分離上の 2 つ以外の残り 6 つのセグメントは H9N2 由来で、中国の上海・浙江・江蘇などの土地にいる鶏群からのものであった。

野鳥が移動する過程で、長江デルタ地域の鴨群・鶏群との間で reassortant を起こした可能性が高いと考えられている。

上海市を流れる黄浦江 (Huangpu river) で起こった、伝染病で死んだ豚の大量投棄 (6 ， 000 ～ 10 ， 000 頭 ) と今回の鳥インフルエンザとの関連性は、豚の死骸から H7N9 ウィルスが検出されなかったことを根拠に否定されている。 ( 豚の伝染病が何であったのかという報道は無い。 )

また、同時期に四川省で 1.000 羽のアヒルの死骸が大量投棄されているのも発見されたが、死因が特定されず、今回の H7N9 との関連性も確認されていない。


HA and PB2 mutations associated with virus adaptation in mammals

H3 a.a. position (H5 no.)110

(103)158

160 (156)

224226

(222)228

(224)318

PB2:627

PB2:701

A/H5N1 wild-type H N T N Q G T E D

A/H5N1 mutant Y D A K L S I K N

A/Shanghai/1/2013 Q N A N Q G T K D

A/Shanghai/2/2013 Q N A N L G T K D

A/Chicken/Shanghai/S1053/2013 Q N A N L G T E D

A/Environment/Shanghai/S1088/2013

Q N A N L G T E D

A/Pigeon/Shanghai/S1069/2013 Q N A N L G T E D

A/Anhui/1/2013 Q N A N L G T K D

A/Hangzhou/1/2013 Q N A N I* G T -- D

A/Hangzhou/2/2013 Q N A N L G T K D

A/Hangzhou/3/2013 Q N A N L G T K D

A/Environment/Hangzhou/34/2013 Q N A N L G T E D

A/Zhejiang/DTID-ZJU01/2013 Q N A N L G T E N

A/chicken/Zhejiang/DTID-ZJU01/2013

Q N A N Q G T E D

Fouchier et al. Science (2012) 336:1534 [HA:H110Y, T160A, Q226L, G228S and PB2:E627K]Kawaoka et al. Nature (2012) 486:420 [HA: N158D, N224K, Q226L, T318I]

Chen et al. Lancet (2013) [HA: T156A, Q226L and PB2:D701N]

Gao et al. NEJM (2013) and Kageyama et al. Eurosurveillance (2013) 18:20453 [HA: T156A, Q226L and PB2:E627K]

Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b


HA 遺伝子開裂部位＝低病原性リシン、アルギニンの連続配列の欠如

proteolytic cleavage motif

Absence of polybasic sequences (K and R) in the recent H7N9 indicates low pathogenicity. Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b


1_PB2

human H1N1pdm09

swine flu

human H3N2

avian flu

A/Environment/Hangzhou/34/2013 | A / H7N9 | 2013-04-04 | PB2 A/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | PB2 A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | PB2 A/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | PB2 A/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | PB2 A/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | PB2 (D701N) A/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | PB2 (E627K) A/Anhui/1/2013 | A / H7N9 | 2013-01-01 | PB2 (E627K) A/Hangzhou/3/2013 | A / H7N9 | 2013-04-02 | PB2 (E627K) A/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | PB2 (E627K) A/Hangzhou/2/2013 | A / H7N9 | 2013-03-25 | PB2 (E627K) A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | PB2 A/chicken/Shanghai/C1/2012 | A / H9N2 | PB2 | 2012-01-01

A/chicken/Zhejiang/611/2011 | A / H9N2 | PB2 | 2011-06-01 A/Netherlands/127/03 | A / H7N7 | PB2 | 2003-01-01

A/green-winged teal/Xianghai/430/2011 | A / H5N2 | PB2 | 2011-10-01 A/canvasback/Xianghai/428/2011 | A / H5N2 | PB2 | 2011-10-01

A/duck/Jiangsu/4/2010 | A / H3N6 | PB2 | 2010-03-01 A/baikal teal/Xianghai/426/2011 | A / H5N2 | PB2 | 2011-10-01 A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | PB2 | 2011-10-01

A/swine/Guangdong/K4/2011 | A / H4N8 | PB2 | 2011-10-21 A/duck/Guangdong/W12/2011 | A / H3N2 | PB2 | 2011-12-22

A/duck/Hubei/5/2010 | A / H6N6 | PB2 | 2010-05-22 A/swine/Hubei/101/2009 | A / H1N1 | PB2 | 2009-08-18

A/duck/Zhejiang/10/2011 | A / H7N3 | PB2 | 2011-06-01 A/duck/Zhejiang/12/2011 | A / H7N3 | PB2 | 2011-06-01

A/duck/Zhejiang/0611-8/2011 | A / H1N3 | PB2 | 2011-06-01 A/duck/Jiangsu/10-d4/2011 | A / H11N3 | PB2 | 2011-10-01 A/duck/Zhejiang/0224-6/2011 | A / H1N2 | PB2 | 2011-01-01

A/duck/Jiangsu/1-15/2011 | A / H4N2 | PB2 | 2011-01-12 A/duck/Jiangsu/m234/2012 | A / H5N2 | PB2 | 2012-01-18

A/duck/Guangxi/GXd-2/2010 | A / H6N2 | PB2 | 2010-04-02 A/baikal teal/Xianghai/421/2011 | A / H9N2 | PB2 | 2011-10-01

A/chicken/Vietnam/212/2005 | A / H5N1 | PB2 | 2005-12-09 A/duck/Guangxi/GXd-5/2010 | A / H6N1 | PB2 | 2010-05-08

A/turkey/Minnesota/1/1988 | A / H7N9 | PB2 | 1988-07-13 A/blue-winged teal/Ohio/566/2006 | A / H7N9 | PB2 | 2006-01-01 A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | PB2 | 2011-01-08 A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | PB2 | 2008-02-07 A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | PB2 | 2008-03-05

A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | PB2 | 1995-05-21 A/Shanghai/60T/2009 | A / H1N1 | PB2 | 2009-05-28 A/Shanghai/37T/2009 | A / H1N1 | PB2 | 2009-05-24 A/Zhejiang/2/2009 | A / H1N1 | PB2 | 2009-05-31 A/Guangdong/02/2009 | A / H1N1 | PB2 | 2009-05-29 A/Zhoushan/52/2009 | A / H1N1 | PB2 | 2009-12-19 A/Shandong/1/2009 | A / H1N1 | PB2 | 2009-05-10 A/Nanjing/2/2009 | A / H1N1 | PB2 | 2009-06-17 A/Beijing/01/2009 | A / H1N1 | PB2 | 2009-05-15(2) A/Beijing/01/2009 | A / H1N1 | PB2 | 2009-05-15 A/GuangzhouSB/01/2009 | A / H1N1 | PB2 | 2009-05-17 A/Jiangsu/S61/2009 | A / H1N1 | PB2 | 2009-11-10 A/swine/Hong Kong/2237/2010 | A / H1N2 | PB2 | 2010-08-02 A/swine/Hubei/04/2009 | A / H1N2 | PB2 | 2009-03-10 A/swine/Guangdong/1/2010 | A / H1N2 | PB2 | 2010-01-30

A/swine/Guangdong/1/2010 | A / H1N1 | PB2 | 2010-01-15 A/swine/Guangdong/2712/2010 | A / H1N2 | PB2 | 2010-08-26 A/swine/Guangdong/2676/2010 | A / H1N2 | PB2 | 2010-08-26

A/swine/Guangdong/09/2009 | A / H1N1 | PB2 | 2009-09-02 A/swine/Guangdong/05/2009 | A / H1N1 | PB2 | 2009-05-05

A/Jilin-Chuanying/1156/2011 | A / H3N2 | PB2 | 2011-03-03 A/Hunan-Yanfeng/165/2011 | A / H3N2 | PB2 | 2011-04-14 A/Heilongjiang-Nangang/124/2011 | A / H3N2 | PB2 | 2011-03-08 A/Shanghai-Luwan/188/2011 | A / H3N2 | PB2 | 2011-02-14 A/Shanghai-Fengxian/1170/2011 | A / H3N2 | PB2 | 2011-05-10 A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | PB2 | 2011-03-09 A/Tianjin-Hedong/195/2011 | A / H3N2 | PB2 | 2011-02-15 A/Beijing-Xicheng/1409/2011 | A / H3N2 | PB2 | 2011-02-22 A/Hunan-Beihu/1143/2011 | A / H3N2 | PB2 | 2011-03-11 A/Chongqing-Wanzhou/182/2011 | A / H3N2 | PB2 | 2011-02-20

100

8876

73

70100

9692

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757399

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100

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9994

100

9991

100

92

100

99

98

100

9982 100

99

9779

70

100100

88

99

85Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b


2_PB1

avian flu

human H1N1pdm09

swine flu

human H3N2

A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | PB1 A/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | PB1 A/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | PB1 A/Anhui/1/2013 | A / H7N9 | 2013-01-01 | PB1 A/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | PB1 A/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | PB1 A/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | PB1 A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | PB1 A/chicken/Shanghai/C1/2012 | A / H9N2 | PB1 | 2012-01-01 A/chicken/Zhejiang/611/2011 | A / H9N2 | PB1 | 2011-06-01 A/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | PB1

A/duck/Guangdong/W12/2011 | A / H3N2 | PB1 | 2011-12-22 A/swine/Guangdong/K4/2011 | A / H4N8 | PB1 | 2011-10-21

A/duck/Jiangsu/1-15/2011 | A / H4N2 | PB1 | 2011-01-12 A/duck/Guangxi/GXd-5/2010 | A / H6N1 | PB1 | 2010-05-08

A/duck/Jiangsu/4/2010 | A / H3N6 | PB1 | 2010-03-01 A/duck/Jiangsu/m234/2012 | A / H5N2 | PB1 | 2012-01-18 A/baikal teal/Xianghai/421/2011 | A / H9N2 | PB1 | 2011-10-01

A/duck/Guangxi/GXd-2/2010 | A / H6N2 | PB1 | 2010-04-02 A/duck/Zhejiang/0224-6/2011 | A / H1N2 | PB1 | 2011-01-01 A/green-winged teal/Xianghai/430/2011 | A / H5N2 | PB1 | 2011-10-01 A/canvasback/Xianghai/428/2011 | A / H5N2 | PB1 | 2011-10-01 A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | PB1 | 2011-10-01 A/baikal teal/Xianghai/426/2011 | A / H5N2 | PB1 | 2011-10-01 A/duck/Zhejiang/12/2011 | A / H7N3 | PB1 | 2011-06-01 A/duck/Jiangsu/10-d4/2011 | A / H11N3 | PB1 | 2011-10-01 A/duck/Zhejiang/10/2011 | A / H7N3 | PB1 | 2011-06-01 A/duck/Zhejiang/0611-8/2011 | A / H1N3 | PB1 | 2011-06-01

A/duck/Hubei/5/2010 | A / H6N6 | PB1 | 2010-05-22 A/swine/Hubei/101/2009 | A / H1N1 | PB1 | 2009-08-18

A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | PB1 | 2008-02-07 A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | PB1 | 2008-03-05

A/blue-winged teal/Ohio/566/2006 | A / H7N9 | PB1 | 2006-01-01 A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | PB1 | 2011-01-08

A/turkey/Minnesota/1/1988 | A / H7N9 | PB1 | 1988-07-13 A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | PB1 | 1995-05-21

A/Jilin-Chuanying/1156/2011 | A / H3N2 | PB1 | 2011-03-03 A/Hunan-Yanfeng/165/2011 | A / H3N2 | PB1 | 2011-04-14 A/Heilongjiang-Nangang/124/2011 | A / H3N2 | PB1 | 2011-03-08

A/Shanghai-Luwan/188/2011 | A / H3N2 | PB1 | 2011-02-14 A/Shanghai-Fengxian/1170/2011 | A / H3N2 | PB1 | 2011-05-10 A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | PB1 | 2011-03-09 A/Tianjin-Hedong/195/2011 | A / H3N2 | PB1 | 2011-02-15 A/Beijing-Xicheng/1409/2011 | A / H3N2 | PB1 | 2011-02-22 A/Chongqing-Wanzhou/182/2011 | A / H3N2 | PB1 | 2011-02-20 A/Hunan-Beihu/1143/2011 | A / H3N2 | PB1 | 2011-03-11 A/Shanghai/60T/2009 | A / H1N1 | PB1 | 2009-05-28 A/Zhejiang/2/2009 | A / H1N1 | PB1 | 2009-05-31 A/Shanghai/37T/2009 | A / H1N1 | PB1 | 2009-05-24 A/Guangdong/02/2009 | A / H1N1 | PB1 | 2009-05-29 A/GuangzhouSB/01/2009 | A / H1N1 | PB1 | 2009-05-17 A/Beijing/01/2009 | A / H1N1 | PB1 | 2009-05-15 A/Nanjing/2/2009 | A / H1N1 | PB1 | 2009-06-17 A/Beijing/01/2009 | A / H1N1 | PB1 | 2009-05-15(2) A/Jiangsu/S61/2009 | A / H1N1 | PB1 | 2009-11-10 A/Zhoushan/52/2009 | A / H1N1 | PB1 | 2009-12-19 A/Shandong/1/2009 | A / H1N1 | PB1 | 2009-05-10

A/swine/Guangdong/2676/2010 | A / H1N2 | PB1 | 2010-08-26 A/swine/Guangdong/2712/2010 | A / H1N2 | PB1 | 2010-08-26 A/swine/Guangdong/1/2010 | A / H1N1 | PB1 | 2010-01-15

A/swine/Hong Kong/2237/2010 | A / H1N2 | PB1 | 2010-08-02 A/swine/Hubei/04/2009 | A / H1N2 | PB1 | 2009-03-10 A/swine/Guangdong/1/2010 | A / H1N2 | PB1 | 2010-01-30

A/swine/Guangdong/05/2009 | A / H1N1 | PB1 | 2009-05-05 A/swine/Guangdong/09/2009 | A / H1N1 | PB1 | 2009-09-02100

100

9899868782

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86

77

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97

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82969484

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100

97

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96

97

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99

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0.02



3_PA

avian flu

human H1N1pdm09

swine flu

human H3N2

A/Shanghai/2/2013 | H7N9 | 2013-01-01 | PA A/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | PA A/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | PA A/Anhui/1/2013 | H7N9 | 2013-01-01 | PA A/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | PA A/Shanghai/1/2013 | H7N9 | 2013-01-01| PA A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | PA

A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | PA A/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | PA A/chicken/Shanghai/C1/2012 | A / H9N2 | PA | 2012-01-01 A/chicken/Zhejiang/611/2011 | A / H9N2 | PA | 2011-06-01

A/duck/Zhejiang/12/2011 | A / H7N3 | PA | 2011-06-01 A/duck/Zhejiang/0611-8/2011 | A / H1N3 | PA | 2011-06-01 A/duck/Zhejiang/10/2011 | A / H7N3 | PA | 2011-06-01 A/duck/Jiangsu/10-d4/2011 | A / H11N3 | PA | 2011-10-01

A/duck/Hubei/5/2010 | A / H6N6 | PA | 2010-05-22 A/canvasback/Xianghai/428/2011 | A / H5N2 | PA | 2011-10-01

A/green-winged teal/Xianghai/430/2011 | A / H5N2 | PA | 2011-10-01 A/duck/Jiangsu/4/2010 | A / H3N6 | PA | 2010-03-01

A/duck/Jiangsu/1-15/2011 | A / H4N2 | PA | 2011-01-12 A/duck/Jiangsu/m234/2012 | A / H5N2 | PA | 2012-01-18

A/duck/Guangxi/GXd-5/2010 | A / H6N1 | PA | 2010-05-08 A/baikal teal/Xianghai/421/2011 | A / H9N2 | PA | 2011-10-01 A/swine/Guangdong/K4/2011 | A / H4N8 | PA | 2011-10-21 A/duck/Guangxi/GXd-2/2010 | A / H6N2 | PA | 2010-04-02

A/duck/Zhejiang/0224-6/2011 | A / H1N2 | PA | 2011-01-01 A/duck/Guangdong/W12/2011 | A / H3N2 | PA | 2011-12-22

A/baikal teal/Xianghai/426/2011 | A / H5N2 | PA | 2011-10-01 A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | PA | 2011-10-01

A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | PA | 1995-05-21 A/turkey/Minnesota/1/1988 | A / H7N9 | PA | 1988-07-13

A/swine/Guangdong/2676/2010 | A / H1N2 | PA | 2010-08-26 A/swine/Guangdong/2712/2010 | A / H1N2 | PA | 2010-08-26

A/swine/Guangdong/1/2010 | A / H1N1 | PA | 2010-01-15 A/swine/Hong Kong/2237/2010 | A / H1N2 | PA | 2010-08-02

A/swine/Guangdong/1/2010 | A / H1N2 | PA | 2010-01-30 A/swine/Hubei/04/2009 | A / H1N2 | PA | 2009-03-10 A/GuangzhouSB/01/2009 | A / H1N1 | PA | 2009-05-17 A/Jiangsu/S61/2009 | A / H1N1 | PA | 2009-11-10 A/Zhoushan/52/2009 | A / H1N1 | PA | 2009-12-19 A/Nanjing/2/2009 | A / H1N1 | PA | 2009-06-17

A/Shanghai/37T/2009 | A / H1N1 | PA | 2009-05-24 A/Guangdong/02/2009 | A / H1N1 | PA | 2009-05-29 A/Shanghai/60T/2009 | A / H1N1 | PA | 2009-05-28 A/Zhejiang/2/2009 | A / H1N1 | PA | 2009-05-31

A/Shandong/1/2009 | A / H1N1 | PA | 2009-05-10 A/Beijing/01/2009 | A / H1N1 | PA | 2009-05-15 A/Beijing/01/2009 | A / H1N1 | PA | 2009-05-15(2)

A/blue-winged teal/Ohio/566/2006 | A / H7N9 | PA | 2006-01-01 A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | PA | 2011-01-08 A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | PA | 2008-02-07

A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | PA | 2008-03-05 A/swine/Hubei/101/2009 | A / H1N1 | PA | 2009-08-18 A/swine/Guangdong/05/2009 | A / H1N1 | PA | 2009-05-05 A/swine/Guangdong/09/2009 | A / H1N1 | PA | 2009-09-02

A/Heilongjiang-Nangang/124/2011 | A / H3N2 | PA | 2011-03-08 A/Hunan-Yanfeng/165/2011 | A / H3N2 | PA | 2011-04-14 A/Jilin-Chuanying/1156/2011 | A / H3N2 | PA | 2011-03-03 A/Shanghai-Luwan/188/2011 | A / H3N2 | PA | 2011-02-14 A/Shanghai-Fengxian/1170/2011 | A / H3N2 | PA | 2011-05-10 A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | PA | 2011-03-09 A/Beijing-Xicheng/1409/2011 | A / H3N2 | PA | 2011-02-22 A/Tianjin-Hedong/195/2011 | A / H3N2 | PA | 2011-02-15 A/Chongqing-Wanzhou/182/2011 | A / H3N2 | PA | 2011-02-20 A/Hunan-Beihu/1143/2011 | A / H3N2 | PA | 2011-03-11

100

8483100

86

98100

100100

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73

9998

100100

99100

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82

7989

100

95

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91

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85

79100

0.02



4_HA

human H1N1pdm09

swine flu

avian flu

human H3N2

A/Hangzhou/1/2013 | A / H7N9 | 2013-03-24 | HA A/Environment/Hangzhou/34/2013 | A / H7N9 | 2013-04-04 | HA A/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | HA A/chicken/Jiangsu/K27/2013 | A / H7N9 | 2013-04-01 | HA A/Hangzhou/3/2013 | A / H7N9 | 2013-04-02 | HA A/Shanghai/2/2013 | 2013-01-01 | H7N9 | HA A/Anhui/1/2013 | 2013-01-01 | H7N9 | HA A/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | HA A/chicken/Jiangsu/K89/2013 | A / H7N9 | 2013-04-01 | HA A/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | HA A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | HA A/Hangzhou/2/2013 | A / H7N9 | 2013-03-25 | HA A/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | HA A/Shanghai/1/2013 | 2013-01-01 | H7N9 | HA A/duck/Zhejiang/10/2011 | A / H7N3 | HA | 2011-06-01 A/duck/Zhejiang/12/2011 | A / H7N3 | HA | 2011-06-01

A/turkey/Minnesota/1/1988 | A / H7N9 | HA | 1988-07-13 A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | HA | 1995-05-21 A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | HA | 2011-01-08 A/blue-winged teal/Ohio/566/2006 | A / H7N9 | HA | 2006-01-01 A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | HA | 2008-02-07 A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | HA | 2008-03-05

A/duck/Jiangsu/1-15/2011 | A / H4N2 | HA | 2011-01-12 A/swine/Guangdong/K4/2011 | A / H4N8 | HA | 2011-10-21

A/duck/Guangdong/W12/2011 | A / H3N2 | HA | 2011-12-22 A/duck/Jiangsu/4/2010 | A / H3N6 | HA | 2010-03-01

A/Beijing-Xicheng/1409/2011 | A / H3N2 | HA | 2011-02-22 A/Hunan-Beihu/1143/2011 | A / H3N2 | HA | 2011-03-11 A/Chongqing-Wanzhou/182/2011 | A / H3N2 | HA | 2011-02-20 A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | HA | 2011-03-09 A/Shanghai-Fengxian/1170/2011 | A / H3N2 | HA | 2011-05-10 A/Shanghai-Luwan/188/2011 | A / H3N2 | HA | 2011-02-14 A/Hunan-Yanfeng/165/2011 | A / H3N2 | HA | 2011-04-14 A/Jilin-Chuanying/1156/2011 | A / H3N2 | HA | 2011-03-03 A/Heilongjiang-Nangang/124/2011 | A / H3N2 | HA | 2011-03-08 A/Tianjin-Hedong/195/2011 | A / H3N2 | HA | 2011-02-15

A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | HA A/chicken/Shanghai/C1/2012 | A / H9N2 | HA | 2012-01-01 A/chicken/Zhejiang/611/2011 | A / H9N2 | HA | 2011-06-01 A/baikal teal/Xianghai/421/2011 | A / H9N2 | HA | 2011-10-01 A/duck/Jiangsu/10-d4/2011 | A / H11N3 | HA | 2011-10-01

A/baikal teal/Xianghai/426/2011 | A / H5N2 | HA | 2011-10-01 A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | HA | 2011-10-01 A/green-winged teal/Xianghai/430/2011 | A / H5N2 | HA | 2011-10-01 A/canvasback/Xianghai/428/2011 | A / H5N2 | HA | 2011-10-01 A/duck/Jiangsu/m234/2012 | A / H5N2 | HA | 2012-01-18

A/duck/Hubei/5/2010 | A / H6N6 | HA | 2010-05-22 A/duck/Guangxi/GXd-5/2010 | A / H6N1 | HA | 2010-05-08

A/duck/Guangxi/GXd-2/2010 | A / H6N2 | HA | 2010-04-02 A/duck/Zhejiang/0224-6/2011 | A / H1N2 | HA | 2011-01-01 A/duck/Zhejiang/0611-8/2011 | A / H1N3 | HA | 2011-06-01

A/swine/Guangdong/1/2010 | A / H1N1 | HA | 2010-01-15 A/swine/Hubei/101/2009 | A / H1N1 | HA | 2009-08-18

A/swine/Guangdong/05/2009 | A / H1N1 | HA | 2009-05-05 A/swine/Guangdong/09/2009 | A / H1N1 | HA | 2009-09-02 A/swine/Guangdong/1/2010 | A / H1N2 | HA | 2010-01-30 A/swine/Hubei/04/2009 | A / H1N2 | HA | 2009-03-10 A/swine/Guangdong/2676/2010 | A / H1N2 | HA | 2010-08-26 A/swine/Guangdong/2712/2010 | A / H1N2 | HA | 2010-08-26 A/swine/Hong Kong/2237/2010 | A / H1N2 | HA | 2010-08-02 A/Beijing/01/2009 | A / H1N1 | HA | 2009-05-15 A/GuangzhouSB/01/2009 | A / H1N1 | HA | 2009-05-17 A/Nanjing/2/2009 | A / H1N1 | HA | 2009-06-17 A/Shandong/1/2009 | A / H1N1 | HA | 2009-05-10 A/Jiangsu/S61/2009 | A / H1N1 | HA | 2009-11-10 A/Guangdong/02/2009 | A / H1N1 | HA | 2009-05-29 A/Zhoushan/52/2009 | A / H1N1 | HA | 2009-12-19 A/Shanghai/37T/2009 | A / H1N1 | HA | 2009-05-24 A/Shanghai/60T/2009 | A / H1N1 | HA | 2009-05-28 A/Zhejiang/2/2009 | A / H1N1 | HA | 2009-05-31

99

8699

748099

90

99

99

99

99

9999

868899

98849896

99

99

99

99

9799

99

99

99

78

9996

99

99

98

99

99

80

9994

99

99

avian flu



5_NP

avian flu

human H1N1pdm09

swine flu

human H3N2

A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | NP A/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | NP A/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | NP A/Anhui/1/2013 | A / H7N9 | 2013-01-01 | NP A/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | NP A/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | NP A/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | NP

A/chicken/Zhejiang/611/2011 | A / H9N2 | NP | 2011-06-01 A/chicken/Shanghai/C1/2012 | A / H9N2 | NP | 2012-01-01

A/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | NP A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | NP

A/duck/Guangxi/GXd-5/2010 | A / H6N1 | NP | 2010-05-08 A/duck/Jiangsu/m234/2012 | A / H5N2 | NP | 2012-01-18 A/duck/Jiangsu/1-15/2011 | A / H4N2 | NP | 2011-01-12

A/duck/Jiangsu/4/2010 | A / H3N6 | NP | 2010-03-01 A/duck/Hubei/5/2010 | A / H6N6 | NP | 2010-05-22 A/baikal teal/Xianghai/421/2011 | A / H9N2 | NP | 2011-10-01

A/wild duck/Mongolia/1-241/2008 | A / H7N9 | 2008-04-01 | NP A/swine/Guangdong/K4/2011 | A / H4N8 | NP | 2011-10-21 A/duck/Zhejiang/0224-6/2011 | A / H1N2 | NP | 2011-01-01 A/duck/Zhejiang/10/2011 | A / H7N3 | NP | 2011-06-01 A/duck/Guangdong/W12/2011 | A / H3N2 | NP | 2011-12-22 A/duck/Zhejiang/12/2011 | A / H7N3 | NP | 2011-06-01 A/duck/Jiangsu/10-d4/2011 | A / H11N3 | NP | 2011-10-01

A/duck/Zhejiang/0611-8/2011 | A / H1N3 | NP | 2011-06-01 A/swine/Hubei/101/2009 | A / H1N1 | NP | 2009-08-18

A/duck/Guangxi/GXd-2/2010 | A / H6N2 | NP | 2010-04-02 A/baikal teal/Xianghai/426/2011 | A / H5N2 | NP | 2011-10-01 A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | NP | 2011-10-01 A/canvasback/Xianghai/428/2011 | A / H5N2 | NP | 2011-10-01 A/green-winged teal/Xianghai/430/2011 | A / H5N2 | NP | 2011-10-01

A/turkey/Minnesota/1/1988 | A / H7N9 | NP | 1988-07-13 A/blue-winged teal/Ohio/566/2006 | A / H7N9 | NP | 2006-01-01

A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | NP | 2011-01-08 A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | NP | 1995-05-21

A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | NP | 2008-02-07 A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | NP | 2008-03-05

A/Shanghai/60T/2009 | A / H1N1 | NP | 2009-05-28 A/Shandong/1/2009 | A / H1N1 | NP | 2009-05-10 A/Shanghai/37T/2009 | A / H1N1 | NP | 2009-05-24 A/Guangdong/02/2009 | A / H1N1 | NP | 2009-05-29 A/Zhejiang/2/2009 | A / H1N1 | NP | 2009-05-31 A/Zhoushan/52/2009 | A / H1N1 | NP | 2009-12-19 A/Beijing/01/2009 | A / H1N1 | NP | 2009-05-15 A/Nanjing/2/2009 | A / H1N1 | NP | 2009-06-17 A/Beijing/01/2009 | A / H1N1 | NP | 2009-05-15(2) A/GuangzhouSB/01/2009 | A / H1N1 | NP | 2009-05-17 A/Jiangsu/S61/2009 | A / H1N1 | NP | 2009-11-10

A/swine/Hong Kong/2237/2010 | A / H1N2 | NP | 2010-08-02 A/swine/Hubei/04/2009 | A / H1N2 | NP | 2009-03-10 A/swine/Guangdong/1/2010 | A / H1N2 | NP | 2010-01-30 A/swine/Guangdong/1/2010 | A / H1N1 | NP | 2010-01-15 A/swine/Guangdong/2712/2010 | A / H1N2 | NP | 2010-08-26 A/swine/Guangdong/2676/2010 | A / H1N2 | NP | 2010-08-26

A/swine/Guangdong/09/2009 | A / H1N1 | NP | 2009-09-02 A/swine/Guangdong/05/2009 | A / H1N1 | NP | 2009-05-05

A/Shanghai-Fengxian/1170/2011 | A / H3N2 | NP | 2011-05-10 A/Hunan-Yanfeng/165/2011 | A / H3N2 | NP | 2011-04-14 A/Heilongjiang-Nangang/124/2011 | A / H3N2 | NP | 2011-03-08 A/Jilin-Chuanying/1156/2011 | A / H3N2 | NP | 2011-03-03 A/Shanghai-Luwan/188/2011 | A / H3N2 | NP | 2011-02-14 A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | NP | 2011-03-09 A/Tianjin-Hedong/195/2011 | A / H3N2 | NP | 2011-02-15 A/Hunan-Beihu/1143/2011 | A / H3N2 | NP | 2011-03-11 A/Beijing-Xicheng/1409/2011 | A / H3N2 | NP | 2011-02-22 A/Chongqing-Wanzhou/182/2011 | A / H3N2 | NP | 2011-02-20

8189

75

100

100

10099

98

86

100

100

92

100

100

9693

100

96

94

70100

88

99

100

99

100

80

77

100 100100857284

100

0.02



avian flu

6_NA

human H3N2

swine flu

human H1N1pdm09

swine flu

A/Hangzhou/1/2013 | A / H7N9 | 2013-03-24 | NA A/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | NA A/Hangzhou/3/2013 | A / H7N9 | 2013-04-02 | NA A/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | NA A/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | NA A/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | NA A/Environment/Hangzhou/34/2013 | A / H7N9 | 2013-04-04 | NA A/Hangzhou/2/2013 | A / H7N9 | 2013-03-25 | NA A/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | NA A/Anhui/1/2013 | A / H7N9 | 2013-01-01 | NA A/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | NA A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | NA A/turkey/Minnesota/1/1988 | A / H7N9 | NA | 1988-07-13 A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | NA | 1995-05-21 A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | NA | 2008-03-05 A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | NA | 2008-02-07 A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | NA | 2011-01-08 A/blue-winged teal/Ohio/566/2006 | A / H7N9 | NA | 2006-01-01

A/duck/Jiangsu/4/2010 | A / H3N6 | NA | 2010-03-01 A/duck/Hubei/5/2010 | A / H6N6 | NA | 2010-05-22

A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | NA | 2011-10-01 A/green-winged teal/Xianghai/430/2011 | A / H5N2 | NA | 2011-10-01 A/baikal teal/Xianghai/426/2011 | A / H5N2 | NA | 2011-10-01 A/canvasback/Xianghai/428/2011 | A / H5N2 | NA | 2011-10-01 A/duck/Guangxi/GXd-2/2010 | A / H6N2 | NA | 2010-04-02 A/baikal teal/Xianghai/421/2011 | A / H9N2 | NA | 2011-10-01 A/duck/Zhejiang/0224-6/2011 | A / H1N2 | NA | 2011-01-01

A/duck/Jiangsu/1-15/2011 | A / H4N2 | NA | 2011-01-12 A/duck/Jiangsu/m234/2012 | A / H5N2 | NA | 2012-01-18 A/duck/Guangdong/W12/2011 | A / H3N2 | NA | 2011-12-22 A/chicken/Zhejiang/611/2011 | A / H9N2 | NA | 2011-06-01 A/chicken/Shanghai/C1/2012 | A / H9N2 | NA | 2012-01-01 A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | NA A/swine/Guangdong/1/2010 | A / H1N2 | NA | 2010-01-30 A/swine/Hubei/04/2009 | A / H1N2 | NA | 2009-03-10 A/swine/Guangdong/2712/2010 | A / H1N2 | NA | 2010-08-26 A/swine/Guangdong/2676/2010 | A / H1N2 | NA | 2010-08-26 A/swine/Hong Kong/2237/2010 | A / H1N2 | NA | 2010-08-02 A/Shanghai-Fengxian/1170/2011 | A / H3N2 | NA | 2011-05-10 A/Jilin-Chuanying/1156/2011 | A / H3N2 | NA | 2011-03-03 A/Heilongjiang-Nangang/124/2011 | A / H3N2 | NA | 2011-03-08 A/Hunan-Yanfeng/165/2011 | A / H3N2 | NA | 2011-04-14 A/Shanghai-Luwan/188/2011 | A / H3N2 | NA | 2011-02-14 A/Chongqing-Wanzhou/182/2011 | A / H3N2 | NA | 2011-02-20 A/Hunan-Beihu/1143/2011 | A / H3N2 | NA | 2011-03-11 A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | NA | 2011-03-09 A/Beijing-Xicheng/1409/2011 | A / H3N2 | NA | 2011-02-22 A/Tianjin-Hedong/195/2011 | A / H3N2 | NA | 2011-02-15

A/duck/Zhejiang/10/2011 | A / H7N3 | NA | 2011-06-01 A/duck/Jiangsu/10-d4/2011 | A / H11N3 | NA | 2011-10-01 A/duck/Zhejiang/0611-8/2011 | A / H1N3 | NA | 2011-06-01 A/duck/Zhejiang/12/2011 | A / H7N3 | NA | 2011-06-01

A/swine/Guangdong/K4/2011 | A / H4N8 | NA | 2011-10-21 A/swine/Guangdong/05/2009 | A / H1N1 | NA | 2009-05-05 A/swine/Guangdong/09/2009 | A / H1N1 | NA | 2009-09-02 A/duck/Guangxi/GXd-5/2010 | A / H6N1 | NA | 2010-05-08

A/swine/Hubei/101/2009 | A / H1N1 | NA | 2009-08-18 A/swine/Guangdong/1/2010 | A / H1N1 | NA | 2010-01-15 A/GuangzhouSB/01/2009 | A / H1N1 | NA | 2009-05-17 A/Nanjing/2/2009 | A / H1N1 | NA | 2009-06-17 A/Beijing/01/2009 | A / H1N1 | NA | 2009-05-15 A/Beijing/01/2009 | A / H1N1 | NA | 2009-05-15(2) A/Guangdong/02/2009 | A / H1N1 | NA | 2009-05-29 A/Shandong/1/2009 | A / H1N1 | NA | 2009-05-10 A/Shanghai/37T/2009 | A / H1N1 | NA | 2009-05-24 A/Shanghai/60T/2009 | A / H1N1 | NA | 2009-05-28 A/Zhejiang/2/2009 | A / H1N1 | NA | 2009-05-31 A/Zhoushan/52/2009 | A / H1N1 | NA | 2009-12-19 A/Jiangsu/S61/2009 | A / H1N1 | NA | 2009-11-10

100

98

94

100

95

8484

87

97

95

97

82

88

90

8972

100

9594

92

9295

95



7_MP

avian flu

human H1N1pdm09

swine flu

human H3N2

swine flu

A/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | MP A/Anhui/1/2013 | A / H7N9 | 2013-01-01 | MP A/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | MP A/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | MP A/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | MP A/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | MP A/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | MP A/Hangzhou/1/2013 | A / H7N9 | 2013-03-24 | MP A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | MP

A/chicken/Shanghai/C1/2012 | A / H9N2 | MP | 2012-01-01 A/chicken/Zhejiang/611/2011 | A / H9N2 | MP | 2011-06-01 A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | MP

A/duck/Jiangsu/4/2010 | A / H3N6 | MP | 2010-03-01 A/duck/Guangxi/GXd-5/2010 | A / H6N1 | MP | 2010-05-08

A/duck/Hubei/5/2010 | A / H6N6 | MP | 2010-05-22 A/duck/Guangxi/GXd-2/2010 | A / H6N2 | MP | 2010-04-02

A/duck/Jiangsu/10-d4/2011 | A / H11N3 | MP | 2011-10-01 A/duck/Zhejiang/0611-8/2011 | A / H1N3 | MP | 2011-06-01 A/duck/Zhejiang/12/2011 | A / H7N3 | MP | 2011-06-01 A/duck/Zhejiang/10/2011 | A / H7N3 | MP | 2011-06-01

A/swine/Guangdong/K4/2011 | A / H4N8 | MP | 2011-10-21 A/baikal teal/Xianghai/421/2011 | A / H9N2 | MP | 2011-10-01 A/green-winged teal/Xianghai/430/2011 | A / H5N2 | MP | 2011-10-01

A/canvasback/Xianghai/428/2011 | A / H5N2 | MP | 2011-10-01 A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | MP | 2011-10-01 A/baikal teal/Xianghai/426/2011 | A / H5N2 | MP | 2011-10-01

A/duck/Zhejiang/0224-6/2011 | A / H1N2 | MP | 2011-01-01 A/duck/Guangdong/W12/2011 | A / H3N2 | MP | 2011-12-22

A/duck/Jiangsu/1-15/2011 | A / H4N2 | MP | 2011-01-12 A/duck/Jiangsu/m234/2012 | A / H5N2 | MP | 2012-01-18

A/swine/Guangdong/2676/2010 | A / H1N2 | MP | 2010-08-26 A/swine/Guangdong/2712/2010 | A / H1N2 | MP | 2010-08-26

A/swine/Guangdong/1/2010 | A / H1N1 | MP | 2010-01-15 A/swine/Hong Kong/2237/2010 | A / H1N2 | MP | 2010-08-02

A/swine/Hubei/101/2009 | A / H1N1 | MP | 2009-08-18 A/Zhejiang/2/2009 | A / H1N1 | MP | 2009-05-31 A/Beijing/01/2009 | A / H1N1 | MP | 2009-05-15 A/Beijing/01/2009 | A / H1N1 | MP | 2009-05-15(2) A/Nanjing/2/2009 | A / H1N1 | MP | 2009-06-17 A/GuangzhouSB/01/2009 | A / H1N1 | MP | 2009-05-17 A/Shandong/1/2009 | A / H1N1 | MP | 2009-05-10 A/Jiangsu/S61/2009 | A / H1N1 | MP | 2009-11-10 A/Zhoushan/52/2009 | A / H1N1 | MP | 2009-12-19 A/Guangdong/02/2009 | A / H1N1 | MP | 2009-05-29 A/Shanghai/37T/2009 | A / H1N1 | MP | 2009-05-24 A/Shanghai/60T/2009 | A / H1N1 | MP | 2009-05-28

A/blue-winged teal/Ohio/566/2006 | A / H7N9 | MP | 2006-01-01 A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | MP | 2011-01-08 A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | MP | 1995-05-21 A/turkey/Minnesota/1/1988 | A / H7N9 | MP | 1988-07-13

A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | MP | 2008-02-07 A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | MP | 2008-03-05

A/swine/Guangdong/05/2009 | A / H1N1 | MP | 2009-05-05 A/swine/Guangdong/09/2009 | A / H1N1 | MP | 2009-09-02

A/swine/Guangdong/1/2010 | A / H1N2 | MP | 2010-01-30 A/swine/Hubei/04/2009 | A / H1N2 | MP | 2009-03-10

A/Hunan-Yanfeng/165/2011 | A / H3N2 | MP | 2011-04-14 A/Jilin-Chuanying/1156/2011 | A / H3N2 | MP | 2011-03-03 A/Heilongjiang-Nangang/124/2011 | A / H3N2 | MP | 2011-03-08 A/Shanghai-Luwan/188/2011 | A / H3N2 | MP | 2011-02-14 A/Shanghai-Fengxian/1170/2011 | A / H3N2 | MP | 2011-05-10 A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | MP | 2011-03-09 A/Tianjin-Hedong/195/2011 | A / H3N2 | MP | 2011-02-15 A/Chongqing-Wanzhou/182/2011 | A / H3N2 | MP | 2011-02-20 A/Beijing-Xicheng/1409/2011 | A / H3N2 | MP | 2011-02-22 A/Hunan-Beihu/1143/2011 | A / H3N2 | MP | 2011-03-11

92

74

97

91

100

100

100100

100

99

88

100

100

100

100

100

88100

100

100

100

97

7789

100

88100

0.01



avian flu

human H1N1pdm09

swine flu

human H3N2

8_NS A/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | NS A/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | NS A/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | NS A/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | NS A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | NS A/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | NS A/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | NS A/Anhui/1/2013 | A / H7N9 | 2013-01-01 | NS

A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | NS A/chicken/Zhejiang/611/2011 | A / H9N2 | NS | 2011-06-01

A/chicken/Shanghai/C1/2012 | A / H9N2 | NS | 2012-01-01 A/duck/Hubei/5/2010 | A / H6N6 | NS | 2010-05-22 A/duck/Guangxi/GXd-5/2010 | A / H6N1 | NS | 2010-05-08

A/swine/Guangdong/K4/2011 | A / H4N8 | NS | 2011-10-21 A/duck/Guangdong/W12/2011 | A / H3N2 | NS | 2011-12-22

A/duck/Jiangsu/m234/2012 | A / H5N2 | NS | 2012-01-18 A/duck/Jiangsu/1-15/2011 | A / H4N2 | NS | 2011-01-12

A/green-winged teal/Xianghai/430/2011 | A / H5N2 | NS | 2011-10-01 A/duck/Guangxi/GXd-2/2010 | A / H6N2 | NS | 2010-04-02

A/duck/Zhejiang/0224-6/2011 | A / H1N2 | NS | 2011-01-01 A/duck/Jiangsu/4/2010 | A / H3N6 | NS | 2010-03-01

A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | NS | 2011-10-01 A/canvasback/Xianghai/428/2011 | A / H5N2 | NS | 2011-10-01 A/baikal teal/Xianghai/426/2011 | A / H5N2 | NS | 2011-10-01

A/baikal teal/Xianghai/421/2011 | A / H9N2 | NS | 2011-10-01 A/duck/Zhejiang/10/2011 | A / H7N3 | NS | 2011-06-01 A/duck/Zhejiang/0611-8/2011 | A / H1N3 | NS | 2011-06-01 A/duck/Jiangsu/10-d4/2011 | A / H11N3 | NS | 2011-10-01

A/duck/Zhejiang/12/2011 | A / H7N3 | NS | 2011-06-01 A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | NS | 1995-05-21

A/turkey/Minnesota/1/1988 | A / H7N9 | NS | 1988-07-13 A/blue-winged teal/Ohio/566/2006 | A / H7N9 | NS | 2006-01-01 A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | NS | 2011-01-08

A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | NS | 2008-02-07 A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | NS | 2008-03-05

A/swine/Hubei/101/2009 | A / H1N1 | NS | 2009-08-18 A/Chongqing-Wanzhou/182/2011 | A / H3N2 | NS | 2011-02-20 A/Beijing-Xicheng/1409/2011 | A / H3N2 | NS | 2011-02-22 A/Hunan-Beihu/1143/2011 | A / H3N2 | NS | 2011-03-11 A/Tianjin-Hedong/195/2011 | A / H3N2 | NS | 2011-02-15

A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | NS | 2011-03-09 A/Shanghai-Fengxian/1170/2011 | A / H3N2 | NS | 2011-05-10

A/Shanghai-Luwan/188/2011 | A / H3N2 | NS | 2011-02-14 A/Jilin-Chuanying/1156/2011 | A / H3N2 | NS | 2011-03-03 A/Heilongjiang-Nangang/124/2011 | A / H3N2 | NS | 2011-03-08 A/Hunan-Yanfeng/165/2011 | A / H3N2 | NS | 2011-04-14

A/swine/Guangdong/05/2009 | A / H1N1 | NS | 2009-05-05 A/swine/Guangdong/09/2009 | A / H1N1 | NS | 2009-09-02

A/swine/Guangdong/2676/2010 | A / H1N2 | NS | 2010-08-26 A/swine/Guangdong/2712/2010 | A / H1N2 | NS | 2010-08-26 A/swine/Guangdong/1/2010 | A / H1N1 | NS | 2010-01-15

A/swine/Hubei/04/2009 | A / H1N2 | NS | 2009-03-10 A/swine/Guangdong/1/2010 | A / H1N2 | NS | 2010-01-30 A/swine/Hong Kong/2237/2010 | A / H1N2 | NS | 2010-08-02

A/GuangzhouSB/01/2009 | A / H1N1 | NS | 2009-05-17 A/Beijing/01/2009 | A / H1N1 | NS | 2009-05-15(2) A/Shandong/1/2009 | A / H1N1 | NS | 2009-05-10 A/Nanjing/2/2009 | A / H1N1 | NS | 2009-06-17 A/Beijing/01/2009 | A / H1N1 | NS | 2009-05-15 A/Shanghai/37T/2009 | A / H1N1 | NS | 2009-05-24 A/Shanghai/60T/2009 | A / H1N1 | NS | 2009-05-28 A/Guangdong/02/2009 | A / H1N1 | NS | 2009-05-29 A/Zhejiang/2/2009 | A / H1N1 | NS | 2009-05-31 A/Jiangsu/S61/2009 | A / H1N1 | NS | 2009-11-10 A/Zhoushan/52/2009 | A / H1N1 | NS | 2009-12-19

7098

98

75

100

100

88100

100

99

82100

100

100

99

100

100

100

100

100

100

98

100

96

80

9388



Influenza H7N9 Reassortant

2011 2012 2013

H9N2 chickenA/chicken/Zhejiang/611/2011

H7N9 wild bird

H7N3 duck

H9N2 chickenA/chicken/Shanghai/C1/2012

H7N9 human

A/Shanghai/1/2013

H7N9 humanA/Shanghai/2/2013

A/Anhui/2/2013

A/duck/Zhejiang/12/2011

NA

HA

NP

内部遺伝子

A/Zhejiang/DTID-ZJU01/2013


We gratefully acknowledge the authors, originating and submitting laboratories of the sequences from GISAID’s EpiFlu Database on these analysis is based. The list is detailed below.

All submitters of data may be contacted directly via the GISAID website www.gisaid.org or click on the links above (requires registration with GISAID)

Isolate IDSegment

sCountr

yCollection date Isolate name Originating/Submitting Lab. Submitter

EPI_ISL_138737

8 segments China 26 February 2013 A/Shanghai/1/2013 WHO Chinese National Influenza Center Yang, Lei

EPI_ISL_138738

8 segments China 05 March 2013 A/Shanghai/2/2013 WHO Chinese National Influenza Center Yang, Lei

EPI_ISL_138739

8 segments China 20 March 2013 A/Anhui/1/2013 WHO Chinese National Influenza Center Yang, Lei

EPI_ISL_138977

8 segments China 24 March 2013 A/Hangzhou/1/2013 Hangzhou Center for Disease Control and Prevention

Li, Jun

EPI_ISL_138985

8 segments China 02 April 2013 A/Pigeon/Shanghai/S1069/2013 Harbin Veterinary Research Institute Kong, Huihui

EPI_ISL_138984

8 segments China 03 April 2013 A/Environment/Shanghai/S1088/2013

Harbin Veterinary Research Institute Kong, Huihui

EPI_ISL_138983

8 segments China 03 April 2013 A/Chicken/Shanghai/S1053/2013 Harbin Veterinary Research Institute Kong, Huihui

EPI_ISL_139364 8 segments China April 2013 A/Zhejiang/DTID-ZJU01/2013 State Key Laboratory of Diagnosis and Treatment of Infectious Diseases, Zhejiang University

EPI_ISL_139501 8 segments China April 2013 A/chicken/Zhejiang/DTID-ZJU01/2013 State Key Laboratory of Diagnosis and Treatment of Infectious Diseases, Zhejiang University


Health & Medicine

H7N9 in China 2