Az 1924/2006/EK rendelet szerint élelmiszereknek gyógyhatás nem tulajdonítható!Disclaimer: MentalFitol™ products are not intended to diagnose, treat, cure or prevent any disease.

Pharmacoidea Ltd.Pharmacoidea Ltd.Pharmacoidea Ltd. Pharmacoidea Ltd. The Company: a biotech SME founded in 2006 Szeged Hungary The Company: a biotech SME founded in 2006, Szeged, Hungary

CEO: Tamas Letoha, MD, PhD

Mission: To bring safe and innovative therapeutics againstdiseases with unmet medical needs

• Team: selected from forward thinking scientists interested totranslate basic science results rapidly into innovative therapeuticstranslate basic science results rapidly into innovative therapeutics,incorporating high added value by rational drug design and foodengineeringengineering

• Laboratory: based at the Biological Research Center of theHungarian Academy of Sciences (www.brc.hu)

„„Let food be thy medicineLet food be thy medicine””„„Let food be thy medicineLet food be thy medicineMajor change in consumer’s demands: Major change in consumer’s demands:optimal diet can prevent 25-70% of lifestyle-related diseases → awareness of the benefits of healthy eatingawareness of the benefits of healthy eating

Development of value-added functional food productsp p– the global market of functional food industry will reach 176.7 billion USD in 2013 with a compound annual growth rate of 7 4%billion USD in 2013 with a compound annual growth rate of 7.4%

– developed with scientific tools of the 21st century, foodproducts capable of specific elimination of causative targets of endemic diseases will conquer international food markets

Protein aggregation diseasesProtein aggregation diseasesProtein aggregation diseasesProtein aggregation diseases– Degenerative diseases based on pathological aggregation ofDegenerative diseases based on pathological aggregation of

misfolded proteins

• Alzheimer's disease ( 10% prevalence at the age of 65 yearsAlzheimer s disease ( 10% prevalence at the age of 65 years and 50% at the age of 85 or above)

• Parkinson's disease ( 0.37% of the whole population )

• Type II diabetes (150 million cases worldwide in 2002 )

• Age-related macular degeneration ( 2% of the population g g ( p paged 50 and 30% of the population aged 75 years or more )

– Common molecular pattern

– Presently incurable, prevention is the only option

Aim: development of functional food products containing– Aim: development of functional food products containingscientifically validated agents

Protein aggregates (plaques)Protein aggregates (plaques)β-amyloid (Alzheimer) α-synuclein (Parkinson)

Protein aggregates (plaques)Protein aggregates (plaques)( )

drusen (AMD)amylin

(Type II Diabetes) ( )(Type II Diabetes)

Plaque depositionPlaque depositionPlaque depositionPlaque depositionBrain → Alzheimer ParkinsonBrain → Alzheimer, Parkinson

Pancreas → Type II Diabetes

Eye (retina) → AMD

Plaque in the brainPlaque deposition -> neuronal death -> dementia

Plaque BustersPlaque BustersqqHigh-throughput bioassays + transgenic animal models +

in silico modeling and docking algorithms + structure activity relationshipsin silico modeling and docking algorithms + structure-activity relationships

l l lib f h i l titia molecular library of new chemical entities– like thorough molecular lancets, plaque busters can specifically recognize and

eliminate pathological protein aggregates/plaques (see figure below)

Alzheimer brain Alzheimer brain + Plaque Busters

Healthy brain

MentalFitolMentalFitol™MentalFitolMentalFitol Molecular biology/pharmacology + bioinformatics + clinicsMolecular biology/pharmacology bioinformatics clinics

A mix of health preserving botanical agentsdeveloped with state-of-the-art drug p gdiscovery approaches

Compounds has been validatedfrom bench to bedside clinicalfrom bench to bedside clinicalstudies in Alzheimer’s disease

(Disclaimer: MentalFitol™ food products are not intended to diagnose, treat, cure or prevent any disease.)

MentalFitol™ food familyMentalFitol™ food familyMentalFitol food familyMentalFitol food familyGreat variety from the internationally acknowledged Co’s Great variety from the internationally acknowledged Co sof the PharmacoFood Cluster (~1 billion € turnover/year)

Bakery, pastry, dairy, meat products, matzo, pasta, pizza, sauces, vega food etc.g

MentalFitol™ functional food products offer the pleasure of eating while delivering scientifically validated healthof eating while delivering scientifically validated health-preserving bioactive compounds, thus contributing to the i t f lif lit f l t l tiimprovement of life quality for large costumer populations,,,

(Disclaimer: MentalFitol™ food products are not intended to diagnose, treat, cure or prevent any disease.)

”One Bite Fits All!””One Bite Fits All!”One Bite Fits All!One Bite Fits All!

sausagesready-made meat

sausages

matzo pasta

ContactContactContactContactáTamás Letoha, MD, PhD

Chief Executive Officer (CEO)

Address: Körös sor 50, 6753 Szeged, Hungary

Phone: +36(30)257-7393

E-mail: tamas.letoha@pharmacoidea.eu

Homepage: www.pharmacoidea.euo epage p a aco dea eu