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Pattern of inflammatory diseases in lymph node biopsy

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ABUTH ZARIA,NIGERIA

Text of Pattern of inflammatory diseases in lymph node biopsy

  • 1. PATTERNS OFINFLAMMATORYDISEASES IN LYMPHNODE BIOPSIES INABUTH ,ZARIA . A FIVE YEARREVIEW(2006-2010)BY DR.MUSA EZEKIEL DEPT.OF MEDICINE
  • 2. SYNOPSIS Lymph node Anatomy. Patterns of inflammatory diseases affecting lymph nodes. Discussion. Recommendation Conclusion References.
  • 3. ANATOMYOF THE LYMPH NODE .
  • 4. The Lymph Nodes Anatomy oval, bean shaped structures scattered throughout body along lymph vessels may be deep or superficial concentrated along the respiratory tree and GI tract, in the mammary glands, axillae, and groin filter lymph fluid to trap foreign organisms, cell debris, and tumor cells
  • 5. Lymphatic Organs Lymph Nodes Covered by a fibrous connective tissue capsule Trabeculae extend from cortex to medulla Stroma the internal supportive connective tissue network of reticular fibers
  • 6. Structure of a Lymph Node outer cortex - filled with lymph follicles outer edge of follicle contains more T cells inner germinal center is the site of B-cell proliferation inner medulla - Cortex medullary cords of lymphocytes, macrop hages, plasma cells Medulla (activated B cells)
  • 7. Histology of Lymph Nodesfollicles withgerminal centers
  • 8. Circulation in the Lymph Nodes Lymph enters via a number of afferent lymphatic vessels It then enters a large subcapsular sinus and travels into a number of smaller sinuses It meanders through these sinuses and exits the node at the hilus via efferent vessels The node acts as a settling tank, because there are fewer efferent vessels, lymph stagnates somewhat in the node Only lymph nodes filter lymph! This allows lymphocytes and macrophages time to carry out their protective functions
  • 9. Lymph Flow Through Lymph Nodes fluid enters cortex through afferent vessels filter and trap damaged cells, microorganisms, forei gn substances, tumor cells by reticular fibers macrophages phagocytize some, lymphocytes destroy some by immune defenses exits medulla by efferent vessels at hilus
  • 10. Patterns Of Inflammatory DiseasesIn ABUTH,2006-2010 Total no of cases= 41 3% 19% TB CGI NSA 78%
  • 11. Prevalence of Age-related TBAdenitis161412108 No of cases6420 0-18 19-45 46-64 >65
  • 12. Prevalence of Sex-relatedInflammatory Diseases in ABUTH16141210 TB8 CGI6 NSA420 MALE FEMALE
  • 13. PAEDIATRIC VS ADULT TB 25% ADULT PAED. 75%
  • 14. TB
  • 15. Toxoplasmosis
  • 16. HIV
  • 17. HIV
  • 18. DISCUSSION
  • 19. TB ADENITIS TB adenitis refers to involvement of lymph nodes by members of the M.tuberculosis complex which include M.tuberculosis, M.bovis, M.africanum, M.canet ti and M.caprae . It may be associated with pulmonary TB or other organ involvement but is usually an isolated nding - 20% of all TB cases are extrapulmonary TB
  • 20. Most common EPTB In the US, non - tuberculous mycobacteria are the most common cause of mycobacterial lymphadenitis in children extrapulmonary TB ( EPTB) rates have not declined in the US HIV positive patients with MTB are more likely to have EPTB than HIV negative patients 45 - 70% Vs 15%
  • 21. In HIV positive patients TBLN is associated with CD4 < 300 ( usually